Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.003 0.09 -9999.0 0.0 -0.25 21.0 21.0 epithelial cell differentiation 0.054 0.066 -9999.0 0.0 -0.263 6.0 6.0 CYFIP2 0.028 0.051 -9999.0 0.0 -0.502 2.0 2.0 ENAH -0.016 0.056 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.021 0.072 -9999.0 0.0 -0.502 4.0 4.0 EPHA2 0.015 0.075 -9999.0 0.0 -0.325 10.0 10.0 MYO6 0.008 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.054 -9999.0 0.0 -0.325 5.0 5.0 ABI1/Sra1/Nap1 0.062 0.041 -9999.0 0.0 -0.31 2.0 2.0 AQP5 0.006 0.056 -9999.0 0.0 -0.375 1.0 1.0 CTNND1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.054 -9999.0 0.0 -0.25 6.0 6.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.074 -9999.0 0.0 -0.271 12.0 12.0 EGF -0.091 0.209 -9999.0 0.0 -0.427 58.0 58.0 NCKAP1 0.032 0.024 -9999.0 0.0 -0.325 1.0 1.0 AQP3 0.007 0.053 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.054 0.066 -9999.0 0.0 -0.263 6.0 6.0 GO:0000145 -0.012 0.048 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.06 0.068 -9999.0 0.0 -0.265 6.0 6.0 MLLT4 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.022 0.057 -9999.0 0.0 -0.35 2.0 2.0 ARF6 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.059 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.003 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.031 0.025 -9999.0 0.0 -0.325 1.0 1.0 ZYX 0.007 0.052 -9999.0 0.0 -0.253 6.0 6.0 ARF6/GTP 0.065 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.088 -9999.0 0.0 -0.502 6.0 6.0 EGFR/EGFR/EGF/EGF -0.027 0.129 -9999.0 0.0 -0.383 3.0 3.0 RhoA/GDP 0.056 0.064 -9999.0 0.0 -0.251 6.0 6.0 actin cytoskeleton organization -0.0 0.048 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.274 0.265 -9999.0 0.0 -0.502 124.0 124.0 DIAPH1 0.056 0.107 -9999.0 0.0 -0.684 2.0 2.0 Wnt receptor signaling pathway -0.054 0.066 0.263 6.0 -9999.0 0.0 6.0 RHOA 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.023 0.057 -9999.0 0.0 -0.351 2.0 2.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.0 0.049 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.001 0.051 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.035 0.081 -9999.0 0.0 -0.323 5.0 5.0 SEC6/SEC8 0.006 0.049 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.075 -9999.0 0.0 -0.275 12.0 12.0 HGF/MET -0.042 0.113 -9999.0 0.0 -0.357 4.0 4.0 HGF 0.029 0.035 -9999.0 0.0 -0.325 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.003 0.09 -9999.0 0.0 -0.251 21.0 21.0 actin cable formation 0.013 0.082 0.315 5.0 -0.306 1.0 6.0 KIAA1543 -0.012 0.049 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.005 0.059 -9999.0 0.0 -0.292 2.0 2.0 NCK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.054 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.054 0.066 -9999.0 0.0 -0.263 6.0 6.0 EXOC4 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.009 0.05 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.01 0.055 -9999.0 0.0 -0.253 6.0 6.0 LIMA1 -0.009 0.144 -9999.0 0.0 -0.502 17.0 17.0 ABI1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.002 0.069 0.305 2.0 -9999.0 0.0 2.0 adherens junction assembly 0.008 0.061 0.281 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer/IGF1 -0.125 0.158 -9999.0 0.0 -0.448 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.046 0.021 -9999.0 0.0 -0.224 1.0 1.0 MET -0.118 0.176 -9999.0 0.0 -0.326 90.0 90.0 PLEKHA7 0.01 0.055 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.06 0.058 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.015 0.064 0.333 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization 0.003 0.09 -9999.0 0.0 -0.25 21.0 21.0 regulation of cell-cell adhesion -0.0 0.048 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.003 0.09 -9999.0 0.0 -0.251 21.0 21.0