This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 10 different clustering approaches and 15 clinical features across 185 patients, 76 significant findings detected with P value < 0.05 and Q value < 0.25.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'GENDER', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', and 'RACE'.
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6 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', and 'RACE'.
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CNMF clustering analysis on RPPA data identified 5 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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Consensus hierarchical clustering analysis on RPPA data identified 5 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', 'NUMBER_OF_LYMPH_NODES', and 'RACE'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 6 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', and 'RACE'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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6 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', 'NUMBER_OF_LYMPH_NODES', and 'RACE'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', and 'RACE'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', and 'RACE'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'RADIATION_THERAPY', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', and 'RACE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.151 (0.226) |
0.182 (0.252) |
0.176 (0.247) |
0.425 (0.491) |
0.84 (0.869) |
0.832 (0.866) |
0.0806 (0.141) |
0.0182 (0.0434) |
0.0448 (0.0908) |
0.0328 (0.0712) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
1.66e-05 (9.2e-05) |
1.57e-05 (9.05e-05) |
0.0149 (0.0366) |
0.000524 (0.00218) |
2.03e-05 (0.000101) |
6.96e-06 (6e-05) |
0.00418 (0.0123) |
1.85e-06 (6e-05) |
8.25e-06 (6e-05) |
7.31e-07 (6e-05) |
PATHOLOGIC STAGE | Fisher's exact test |
0.0113 (0.0287) |
0.00014 (0.000636) |
0.0313 (0.069) |
0.00997 (0.0258) |
0.0076 (0.0207) |
2e-05 (0.000101) |
0.0001 (0.000469) |
2e-05 (0.000101) |
1e-05 (6e-05) |
1e-05 (6e-05) |
PATHOLOGY T STAGE | Fisher's exact test |
0.00062 (0.00238) |
0.00054 (0.00219) |
0.00231 (0.00737) |
0.00308 (0.00962) |
6e-05 (0.00029) |
0.00177 (0.00603) |
0.0008 (0.00293) |
0.00089 (0.00318) |
0.00078 (0.00292) |
0.00058 (0.00229) |
PATHOLOGY N STAGE | Fisher's exact test |
0.0142 (0.0355) |
0.0498 (0.0982) |
0.284 (0.36) |
0.0603 (0.113) |
0.0655 (0.121) |
0.0048 (0.0136) |
0.00754 (0.0207) |
0.0434 (0.0895) |
0.104 (0.174) |
0.00997 (0.0258) |
PATHOLOGY M STAGE | Fisher's exact test |
0.275 (0.356) |
0.0436 (0.0895) |
0.0823 (0.142) |
0.0526 (0.0999) |
0.784 (0.828) |
0.343 (0.425) |
0.618 (0.681) |
0.204 (0.273) |
0.235 (0.309) |
0.372 (0.457) |
GENDER | Fisher's exact test |
0.0239 (0.0552) |
0.157 (0.23) |
0.65 (0.711) |
0.132 (0.206) |
0.936 (0.956) |
0.91 (0.935) |
0.379 (0.462) |
0.488 (0.554) |
0.987 (1) |
0.392 (0.47) |
RADIATION THERAPY | Fisher's exact test |
0.034 (0.073) |
0.00846 (0.0227) |
0.495 (0.559) |
0.0897 (0.151) |
0.00198 (0.00646) |
0.00017 (0.00075) |
0.00466 (0.0134) |
0.00105 (0.00366) |
0.00317 (0.0097) |
0.00364 (0.0109) |
KARNOFSKY PERFORMANCE SCORE | Kruskal-Wallis (anova) |
0.105 (0.174) |
0.514 (0.575) |
0.39 (0.47) |
0.0874 (0.149) |
0.262 (0.342) |
0.0361 (0.0762) |
0.327 (0.408) |
0.116 (0.189) |
0.0292 (0.0663) |
0.0516 (0.0993) |
HISTOLOGICAL TYPE | Fisher's exact test |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
NUMBER PACK YEARS SMOKED | Kruskal-Wallis (anova) |
0.121 (0.195) |
0.0463 (0.0926) |
0.395 (0.47) |
0.318 (0.4) |
0.0686 (0.124) |
0.125 (0.199) |
0.194 (0.265) |
0.136 (0.21) |
0.0166 (0.0402) |
0.0185 (0.0434) |
RESIDUAL TUMOR | Fisher's exact test |
0.429 (0.491) |
0.527 (0.585) |
0.0702 (0.124) |
0.152 (0.226) |
0.702 (0.752) |
0.14 (0.213) |
0.187 (0.257) |
0.679 (0.733) |
0.127 (0.201) |
0.669 (0.727) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.0699 (0.124) |
0.175 (0.247) |
0.412 (0.483) |
0.0309 (0.069) |
0.283 (0.36) |
0.0507 (0.0988) |
0.00193 (0.00643) |
0.21 (0.278) |
0.158 (0.231) |
0.0665 (0.122) |
RACE | Fisher's exact test |
1e-05 (6e-05) |
1e-05 (6e-05) |
0.00038 (0.00163) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
1e-05 (6e-05) |
ETHNICITY | Fisher's exact test |
1 (1.00) |
0.825 (0.866) |
0.198 (0.267) |
0.775 (0.824) |
0.404 (0.478) |
0.173 (0.247) |
1 (1.00) |
0.176 (0.247) |
0.418 (0.487) |
0.141 (0.213) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 74 | 33 | 77 |
P value = 0.151 (logrank test), Q value = 0.23
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 184 | 76 | 0.1 - 122.1 (13.0) |
subtype1 | 74 | 39 | 0.4 - 122.1 (14.1) |
subtype2 | 33 | 9 | 1.6 - 83.2 (15.3) |
subtype3 | 77 | 28 | 0.1 - 52.6 (12.6) |
P value = 1.66e-05 (Kruskal-Wallis (anova)), Q value = 9.2e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 184 | 62.4 (11.9) |
subtype1 | 74 | 63.9 (11.9) |
subtype2 | 33 | 69.2 (12.2) |
subtype3 | 77 | 58.1 (10.2) |
P value = 0.0113 (Fisher's exact test), Q value = 0.029
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 47 | 31 | 25 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 5 | 2 | 2 | 0 | 6 | 13 | 12 | 5 | 5 | 3 | 2 | 3 |
subtype2 | 3 | 2 | 1 | 0 | 9 | 7 | 3 | 3 | 0 | 2 | 0 | 0 |
subtype3 | 0 | 1 | 3 | 1 | 32 | 11 | 10 | 6 | 4 | 2 | 3 | 1 |
P value = 0.00062 (Fisher's exact test), Q value = 0.0024
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 32 | 43 | 87 | 5 |
subtype1 | 20 | 8 | 35 | 0 |
subtype2 | 6 | 8 | 14 | 2 |
subtype3 | 6 | 27 | 38 | 3 |
P value = 0.0142 (Fisher's exact test), Q value = 0.036
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 77 | 68 | 12 | 8 |
subtype1 | 19 | 34 | 7 | 3 |
subtype2 | 19 | 8 | 0 | 2 |
subtype3 | 39 | 26 | 5 | 3 |
P value = 0.275 (Fisher's exact test), Q value = 0.36
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 43 | 5 |
subtype2 | 26 | 0 |
subtype3 | 66 | 4 |
P value = 0.0239 (Fisher's exact test), Q value = 0.055
nPatients | FEMALE | MALE |
---|---|---|
ALL | 27 | 157 |
subtype1 | 7 | 67 |
subtype2 | 10 | 23 |
subtype3 | 10 | 67 |
P value = 0.034 (Fisher's exact test), Q value = 0.073
nPatients | NO | YES |
---|---|---|
ALL | 123 | 43 |
subtype1 | 54 | 11 |
subtype2 | 23 | 6 |
subtype3 | 46 | 26 |
P value = 0.105 (Kruskal-Wallis (anova)), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 68 | 73.8 (16.2) |
subtype1 | 9 | 80.0 (15.0) |
subtype2 | 9 | 81.1 (10.5) |
subtype3 | 50 | 71.4 (16.8) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 88 | 96 |
subtype1 | 69 | 5 |
subtype2 | 17 | 16 |
subtype3 | 2 | 75 |
P value = 0.121 (Kruskal-Wallis (anova)), Q value = 0.19
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 98 | 34.5 (21.5) |
subtype1 | 38 | 39.7 (23.9) |
subtype2 | 16 | 34.9 (21.8) |
subtype3 | 44 | 29.8 (18.4) |
P value = 0.429 (Fisher's exact test), Q value = 0.49
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 137 | 12 | 2 | 7 |
subtype1 | 49 | 7 | 0 | 3 |
subtype2 | 27 | 2 | 0 | 0 |
subtype3 | 61 | 3 | 2 | 4 |
P value = 0.0699 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 134 | 2.5 (3.4) |
subtype1 | 60 | 2.9 (3.4) |
subtype2 | 25 | 2.4 (4.9) |
subtype3 | 49 | 2.1 (2.5) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 5 | 114 |
subtype1 | 3 | 0 | 55 |
subtype2 | 3 | 1 | 29 |
subtype3 | 40 | 4 | 30 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 88 |
subtype1 | 2 | 23 |
subtype2 | 0 | 12 |
subtype3 | 4 | 53 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 37 | 42 | 2 | 41 | 37 | 17 | 9 |
P value = 0.182 (logrank test), Q value = 0.25
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 183 | 77 | 0.1 - 122.1 (12.9) |
subtype1 | 37 | 26 | 1.4 - 58.5 (13.5) |
subtype2 | 42 | 16 | 0.4 - 122.1 (13.9) |
subtype4 | 41 | 15 | 0.3 - 47.9 (13.2) |
subtype5 | 37 | 12 | 0.1 - 68.0 (12.8) |
subtype6 | 17 | 6 | 1.6 - 83.2 (12.6) |
subtype7 | 9 | 2 | 2.6 - 23.4 (12.3) |
P value = 1.57e-05 (Kruskal-Wallis (anova)), Q value = 9e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 183 | 62.4 (11.9) |
subtype1 | 37 | 64.3 (11.0) |
subtype2 | 42 | 68.4 (10.1) |
subtype4 | 41 | 55.2 (8.6) |
subtype5 | 37 | 60.6 (11.4) |
subtype6 | 17 | 64.3 (14.1) |
subtype7 | 9 | 63.4 (18.0) |
P value = 0.00014 (Fisher's exact test), Q value = 0.00064
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 4 | 6 | 1 | 47 | 30 | 26 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 2 | 2 | 1 | 0 | 0 | 7 | 6 | 3 | 1 | 1 | 2 | 3 |
subtype2 | 6 | 0 | 1 | 0 | 4 | 8 | 9 | 1 | 3 | 2 | 0 | 0 |
subtype4 | 0 | 1 | 1 | 0 | 18 | 5 | 5 | 2 | 5 | 1 | 1 | 1 |
subtype5 | 0 | 0 | 3 | 1 | 14 | 5 | 6 | 5 | 0 | 1 | 2 | 0 |
subtype6 | 0 | 1 | 0 | 0 | 8 | 3 | 0 | 2 | 0 | 2 | 0 | 0 |
subtype7 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
P value = 0.00054 (Fisher's exact test), Q value = 0.0022
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 31 | 43 | 87 | 5 |
subtype1 | 12 | 3 | 14 | 0 |
subtype2 | 11 | 4 | 22 | 0 |
subtype4 | 4 | 13 | 22 | 1 |
subtype5 | 2 | 14 | 19 | 2 |
subtype6 | 2 | 7 | 5 | 2 |
subtype7 | 0 | 2 | 5 | 0 |
P value = 0.0498 (Fisher's exact test), Q value = 0.098
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 75 | 69 | 12 | 8 |
subtype1 | 7 | 19 | 2 | 1 |
subtype2 | 14 | 18 | 3 | 2 |
subtype4 | 18 | 15 | 5 | 1 |
subtype5 | 21 | 13 | 1 | 2 |
subtype6 | 11 | 2 | 0 | 2 |
subtype7 | 4 | 2 | 1 | 0 |
P value = 0.0436 (Fisher's exact test), Q value = 0.09
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 17 | 5 |
subtype2 | 29 | 0 |
subtype4 | 36 | 2 |
subtype5 | 32 | 2 |
subtype6 | 15 | 0 |
subtype7 | 6 | 0 |
P value = 0.157 (Fisher's exact test), Q value = 0.23
nPatients | FEMALE | MALE |
---|---|---|
ALL | 26 | 157 |
subtype1 | 1 | 36 |
subtype2 | 8 | 34 |
subtype4 | 5 | 36 |
subtype5 | 7 | 30 |
subtype6 | 3 | 14 |
subtype7 | 2 | 7 |
P value = 0.00846 (Fisher's exact test), Q value = 0.023
nPatients | NO | YES |
---|---|---|
ALL | 123 | 42 |
subtype1 | 31 | 3 |
subtype2 | 30 | 5 |
subtype4 | 24 | 13 |
subtype5 | 24 | 11 |
subtype6 | 10 | 5 |
subtype7 | 4 | 5 |
P value = 0.514 (Kruskal-Wallis (anova)), Q value = 0.58
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 67 | 73.7 (16.3) |
subtype1 | 2 | 90.0 (0.0) |
subtype2 | 4 | 82.5 (15.0) |
subtype4 | 25 | 73.2 (17.3) |
subtype5 | 25 | 72.0 (16.1) |
subtype6 | 7 | 77.1 (13.8) |
subtype7 | 4 | 65.0 (19.1) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 94 |
subtype1 | 37 | 0 |
subtype2 | 42 | 0 |
subtype4 | 0 | 41 |
subtype5 | 0 | 37 |
subtype6 | 7 | 10 |
subtype7 | 3 | 6 |
P value = 0.0463 (Kruskal-Wallis (anova)), Q value = 0.093
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 96 | 34.7 (21.7) |
subtype1 | 14 | 46.9 (16.8) |
subtype2 | 23 | 37.6 (26.1) |
subtype4 | 26 | 30.2 (19.5) |
subtype5 | 22 | 29.4 (17.5) |
subtype6 | 7 | 41.3 (29.6) |
subtype7 | 4 | 20.9 (13.0) |
P value = 0.527 (Fisher's exact test), Q value = 0.59
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 135 | 13 | 2 | 7 |
subtype1 | 21 | 5 | 0 | 0 |
subtype2 | 31 | 3 | 0 | 2 |
subtype4 | 34 | 3 | 1 | 1 |
subtype5 | 29 | 2 | 1 | 3 |
subtype6 | 15 | 0 | 0 | 0 |
subtype7 | 5 | 0 | 0 | 1 |
P value = 0.175 (Kruskal-Wallis (anova)), Q value = 0.25
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 134 | 2.5 (3.4) |
subtype1 | 28 | 3.1 (3.0) |
subtype2 | 37 | 2.2 (3.1) |
subtype4 | 26 | 2.6 (2.4) |
subtype5 | 27 | 1.7 (2.6) |
subtype6 | 11 | 4.5 (7.5) |
subtype7 | 5 | 1.4 (1.7) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 4 | 113 |
subtype1 | 0 | 0 | 29 |
subtype2 | 1 | 0 | 33 |
subtype4 | 24 | 3 | 12 |
subtype5 | 16 | 0 | 20 |
subtype6 | 3 | 0 | 14 |
subtype7 | 2 | 1 | 5 |
P value = 0.825 (Fisher's exact test), Q value = 0.87
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 86 |
subtype1 | 2 | 12 |
subtype2 | 1 | 9 |
subtype4 | 2 | 29 |
subtype5 | 1 | 20 |
subtype6 | 0 | 9 |
subtype7 | 0 | 7 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 26 | 28 | 30 | 34 | 8 |
P value = 0.176 (logrank test), Q value = 0.25
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 126 | 44 | 0.1 - 122.1 (13.2) |
subtype1 | 26 | 13 | 2.1 - 46.1 (12.8) |
subtype2 | 28 | 7 | 0.5 - 122.1 (13.7) |
subtype3 | 30 | 11 | 0.3 - 52.6 (12.8) |
subtype4 | 34 | 9 | 0.1 - 68.0 (12.6) |
subtype5 | 8 | 4 | 4.5 - 46.2 (25.1) |
P value = 0.0149 (Kruskal-Wallis (anova)), Q value = 0.037
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 126 | 62.7 (11.5) |
subtype1 | 26 | 68.0 (10.6) |
subtype2 | 28 | 63.2 (11.5) |
subtype3 | 30 | 63.1 (10.1) |
subtype4 | 34 | 58.1 (12.0) |
subtype5 | 8 | 62.2 (11.2) |
P value = 0.0313 (Fisher's exact test), Q value = 0.069
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 6 | 3 | 4 | 1 | 42 | 23 | 17 | 12 | 7 | 2 | 3 | 1 |
subtype1 | 3 | 2 | 1 | 0 | 3 | 5 | 4 | 3 | 2 | 1 | 0 | 1 |
subtype2 | 3 | 0 | 1 | 1 | 9 | 5 | 2 | 4 | 0 | 1 | 0 | 0 |
subtype3 | 0 | 1 | 1 | 0 | 6 | 7 | 6 | 2 | 3 | 0 | 2 | 0 |
subtype4 | 0 | 0 | 1 | 0 | 21 | 4 | 5 | 2 | 1 | 0 | 0 | 0 |
subtype5 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 1 | 1 | 0 | 1 | 0 |
P value = 0.00231 (Fisher's exact test), Q value = 0.0074
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 18 | 35 | 69 | 2 |
subtype1 | 9 | 4 | 13 | 0 |
subtype2 | 4 | 10 | 13 | 0 |
subtype3 | 4 | 4 | 20 | 1 |
subtype4 | 0 | 16 | 17 | 1 |
subtype5 | 1 | 1 | 6 | 0 |
P value = 0.284 (Fisher's exact test), Q value = 0.36
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 62 | 49 | 9 | 3 |
subtype1 | 9 | 13 | 3 | 1 |
subtype2 | 14 | 10 | 1 | 1 |
subtype3 | 12 | 13 | 3 | 1 |
subtype4 | 24 | 9 | 1 | 0 |
subtype5 | 3 | 4 | 1 | 0 |
P value = 0.0823 (Fisher's exact test), Q value = 0.14
nPatients | 0 | 1 |
---|---|---|
ALL | 105 | 4 |
subtype1 | 18 | 1 |
subtype2 | 25 | 0 |
subtype3 | 25 | 2 |
subtype4 | 32 | 0 |
subtype5 | 5 | 1 |
P value = 0.65 (Fisher's exact test), Q value = 0.71
nPatients | FEMALE | MALE |
---|---|---|
ALL | 18 | 108 |
subtype1 | 4 | 22 |
subtype2 | 6 | 22 |
subtype3 | 3 | 27 |
subtype4 | 5 | 29 |
subtype5 | 0 | 8 |
P value = 0.495 (Fisher's exact test), Q value = 0.56
nPatients | NO | YES |
---|---|---|
ALL | 84 | 32 |
subtype1 | 19 | 4 |
subtype2 | 19 | 6 |
subtype3 | 21 | 7 |
subtype4 | 20 | 12 |
subtype5 | 5 | 3 |
P value = 0.39 (Kruskal-Wallis (anova)), Q value = 0.47
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 48 | 69.2 (16.2) |
subtype1 | 4 | 60.0 (28.3) |
subtype2 | 7 | 72.9 (19.8) |
subtype3 | 11 | 69.1 (14.5) |
subtype4 | 21 | 67.1 (13.5) |
subtype5 | 5 | 80.0 (14.1) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 48 | 78 |
subtype1 | 22 | 4 |
subtype2 | 12 | 16 |
subtype3 | 10 | 20 |
subtype4 | 1 | 33 |
subtype5 | 3 | 5 |
P value = 0.395 (Kruskal-Wallis (anova)), Q value = 0.47
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 66 | 36.4 (20.6) |
subtype1 | 11 | 34.7 (17.0) |
subtype2 | 13 | 32.5 (19.2) |
subtype3 | 17 | 48.0 (27.9) |
subtype4 | 21 | 30.2 (14.1) |
subtype5 | 4 | 37.2 (12.8) |
P value = 0.0702 (Fisher's exact test), Q value = 0.12
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 101 | 10 | 1 | 7 |
subtype1 | 20 | 3 | 0 | 3 |
subtype2 | 27 | 0 | 0 | 0 |
subtype3 | 20 | 4 | 0 | 2 |
subtype4 | 29 | 2 | 0 | 2 |
subtype5 | 5 | 1 | 1 | 0 |
P value = 0.412 (Kruskal-Wallis (anova)), Q value = 0.48
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 2.2 (2.8) |
subtype1 | 24 | 2.8 (3.3) |
subtype2 | 20 | 1.8 (2.5) |
subtype3 | 27 | 2.1 (3.0) |
subtype4 | 19 | 1.6 (2.2) |
subtype5 | 7 | 2.9 (2.3) |
P value = 0.00038 (Fisher's exact test), Q value = 0.0016
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 43 | 2 | 73 |
subtype1 | 2 | 0 | 20 |
subtype2 | 7 | 1 | 18 |
subtype3 | 11 | 0 | 18 |
subtype4 | 21 | 0 | 12 |
subtype5 | 2 | 1 | 5 |
P value = 0.198 (Fisher's exact test), Q value = 0.27
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 68 |
subtype1 | 0 | 7 |
subtype2 | 0 | 14 |
subtype3 | 0 | 19 |
subtype4 | 1 | 25 |
subtype5 | 1 | 3 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 23 | 21 | 22 | 26 | 34 |
P value = 0.425 (logrank test), Q value = 0.49
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 126 | 44 | 0.1 - 122.1 (13.2) |
subtype1 | 23 | 11 | 1.4 - 46.2 (18.4) |
subtype2 | 21 | 6 | 0.5 - 122.1 (15.5) |
subtype3 | 22 | 10 | 2.7 - 52.6 (13.0) |
subtype4 | 26 | 7 | 0.3 - 52.3 (12.5) |
subtype5 | 34 | 10 | 0.1 - 68.0 (12.9) |
P value = 0.000524 (Kruskal-Wallis (anova)), Q value = 0.0022
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 126 | 62.7 (11.5) |
subtype1 | 23 | 71.4 (9.4) |
subtype2 | 21 | 64.0 (10.6) |
subtype3 | 22 | 62.8 (10.0) |
subtype4 | 26 | 58.1 (11.6) |
subtype5 | 34 | 59.5 (11.2) |
P value = 0.00997 (Fisher's exact test), Q value = 0.026
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 6 | 3 | 4 | 1 | 42 | 23 | 17 | 12 | 7 | 2 | 3 | 1 |
subtype1 | 3 | 2 | 1 | 0 | 1 | 5 | 3 | 2 | 2 | 2 | 0 | 0 |
subtype2 | 3 | 0 | 1 | 0 | 6 | 5 | 2 | 2 | 0 | 0 | 0 | 0 |
subtype3 | 0 | 0 | 0 | 0 | 4 | 5 | 4 | 3 | 2 | 0 | 2 | 1 |
subtype4 | 0 | 0 | 1 | 1 | 12 | 3 | 6 | 2 | 1 | 0 | 0 | 0 |
subtype5 | 0 | 1 | 1 | 0 | 19 | 5 | 2 | 3 | 2 | 0 | 1 | 0 |
P value = 0.00308 (Fisher's exact test), Q value = 0.0096
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 18 | 35 | 69 | 2 |
subtype1 | 9 | 3 | 10 | 0 |
subtype2 | 4 | 7 | 9 | 0 |
subtype3 | 3 | 3 | 15 | 1 |
subtype4 | 0 | 8 | 18 | 0 |
subtype5 | 2 | 14 | 17 | 1 |
P value = 0.0603 (Fisher's exact test), Q value = 0.11
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 62 | 49 | 9 | 3 |
subtype1 | 6 | 10 | 4 | 2 |
subtype2 | 11 | 9 | 0 | 0 |
subtype3 | 8 | 11 | 2 | 1 |
subtype4 | 14 | 10 | 1 | 0 |
subtype5 | 23 | 9 | 2 | 0 |
P value = 0.0526 (Fisher's exact test), Q value = 0.1
nPatients | 0 | 1 |
---|---|---|
ALL | 105 | 4 |
subtype1 | 13 | 0 |
subtype2 | 20 | 0 |
subtype3 | 16 | 3 |
subtype4 | 26 | 0 |
subtype5 | 30 | 1 |
P value = 0.132 (Fisher's exact test), Q value = 0.21
nPatients | FEMALE | MALE |
---|---|---|
ALL | 18 | 108 |
subtype1 | 4 | 19 |
subtype2 | 5 | 16 |
subtype3 | 1 | 21 |
subtype4 | 1 | 25 |
subtype5 | 7 | 27 |
P value = 0.0897 (Fisher's exact test), Q value = 0.15
nPatients | NO | YES |
---|---|---|
ALL | 84 | 32 |
subtype1 | 19 | 2 |
subtype2 | 15 | 4 |
subtype3 | 13 | 8 |
subtype4 | 13 | 10 |
subtype5 | 24 | 8 |
P value = 0.0874 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 48 | 69.2 (16.2) |
subtype1 | 1 | 90.0 (NA) |
subtype2 | 5 | 82.0 (13.0) |
subtype3 | 6 | 66.7 (17.5) |
subtype4 | 15 | 63.3 (15.4) |
subtype5 | 21 | 70.0 (15.8) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 48 | 78 |
subtype1 | 23 | 0 |
subtype2 | 10 | 11 |
subtype3 | 12 | 10 |
subtype4 | 2 | 24 |
subtype5 | 1 | 33 |
P value = 0.318 (Kruskal-Wallis (anova)), Q value = 0.4
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 66 | 36.4 (20.6) |
subtype1 | 11 | 37.2 (20.2) |
subtype2 | 9 | 34.3 (20.9) |
subtype3 | 14 | 45.5 (21.2) |
subtype4 | 16 | 32.8 (24.8) |
subtype5 | 16 | 32.6 (14.9) |
P value = 0.152 (Fisher's exact test), Q value = 0.23
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 101 | 10 | 1 | 7 |
subtype1 | 18 | 2 | 0 | 2 |
subtype2 | 20 | 0 | 0 | 0 |
subtype3 | 14 | 4 | 0 | 1 |
subtype4 | 24 | 1 | 0 | 0 |
subtype5 | 25 | 3 | 1 | 4 |
P value = 0.0309 (Kruskal-Wallis (anova)), Q value = 0.069
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 2.2 (2.8) |
subtype1 | 23 | 3.9 (4.0) |
subtype2 | 18 | 1.2 (1.8) |
subtype3 | 21 | 1.9 (2.3) |
subtype4 | 12 | 2.5 (2.4) |
subtype5 | 23 | 1.3 (1.8) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 43 | 2 | 73 |
subtype1 | 0 | 0 | 19 |
subtype2 | 3 | 1 | 15 |
subtype3 | 6 | 0 | 15 |
subtype4 | 18 | 0 | 7 |
subtype5 | 16 | 1 | 17 |
P value = 0.775 (Fisher's exact test), Q value = 0.82
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 68 |
subtype1 | 0 | 4 |
subtype2 | 0 | 9 |
subtype3 | 0 | 10 |
subtype4 | 0 | 21 |
subtype5 | 2 | 24 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
Number of samples | 74 | 14 | 42 | 29 | 9 | 16 |
P value = 0.84 (logrank test), Q value = 0.87
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 184 | 77 | 0.1 - 122.1 (13.0) |
subtype1 | 74 | 37 | 0.4 - 122.1 (13.7) |
subtype2 | 14 | 4 | 0.1 - 58.6 (12.5) |
subtype3 | 42 | 13 | 0.5 - 68.0 (12.6) |
subtype4 | 29 | 11 | 0.3 - 44.8 (12.4) |
subtype5 | 9 | 4 | 2.6 - 83.2 (20.8) |
subtype6 | 16 | 8 | 6.3 - 54.0 (19.4) |
P value = 2.03e-05 (Kruskal-Wallis (anova)), Q value = 1e-04
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 184 | 62.5 (11.9) |
subtype1 | 74 | 67.6 (10.5) |
subtype2 | 14 | 60.1 (15.7) |
subtype3 | 42 | 59.9 (10.6) |
subtype4 | 29 | 55.8 (8.5) |
subtype5 | 9 | 59.2 (11.3) |
subtype6 | 16 | 61.3 (14.8) |
P value = 0.0076 (Fisher's exact test), Q value = 0.021
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 46 | 31 | 26 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 8 | 2 | 1 | 0 | 4 | 15 | 13 | 4 | 3 | 4 | 2 | 3 |
subtype2 | 0 | 0 | 0 | 0 | 6 | 2 | 3 | 1 | 0 | 0 | 0 | 0 |
subtype3 | 0 | 1 | 3 | 1 | 18 | 7 | 5 | 3 | 1 | 1 | 2 | 0 |
subtype4 | 0 | 0 | 1 | 0 | 11 | 4 | 5 | 2 | 3 | 1 | 1 | 0 |
subtype5 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3 | 0 | 1 | 0 | 0 |
subtype6 | 0 | 2 | 1 | 0 | 3 | 2 | 0 | 1 | 2 | 0 | 0 | 1 |
P value = 6e-05 (Fisher's exact test), Q value = 0.00029
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 32 | 42 | 88 | 5 |
subtype1 | 24 | 6 | 34 | 0 |
subtype2 | 0 | 4 | 8 | 0 |
subtype3 | 3 | 14 | 23 | 2 |
subtype4 | 2 | 10 | 15 | 1 |
subtype5 | 0 | 4 | 3 | 2 |
subtype6 | 3 | 4 | 5 | 0 |
P value = 0.0655 (Fisher's exact test), Q value = 0.12
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 76 | 69 | 12 | 8 |
subtype1 | 20 | 35 | 5 | 4 |
subtype2 | 7 | 5 | 0 | 0 |
subtype3 | 27 | 10 | 2 | 2 |
subtype4 | 11 | 13 | 3 | 1 |
subtype5 | 6 | 1 | 0 | 1 |
subtype6 | 5 | 5 | 2 | 0 |
P value = 0.784 (Fisher's exact test), Q value = 0.83
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 43 | 5 |
subtype2 | 12 | 0 |
subtype3 | 36 | 2 |
subtype4 | 26 | 1 |
subtype5 | 8 | 0 |
subtype6 | 10 | 1 |
P value = 0.936 (Fisher's exact test), Q value = 0.96
nPatients | FEMALE | MALE |
---|---|---|
ALL | 26 | 158 |
subtype1 | 10 | 64 |
subtype2 | 2 | 12 |
subtype3 | 7 | 35 |
subtype4 | 3 | 26 |
subtype5 | 2 | 7 |
subtype6 | 2 | 14 |
P value = 0.00198 (Fisher's exact test), Q value = 0.0065
nPatients | NO | YES |
---|---|---|
ALL | 123 | 43 |
subtype1 | 56 | 7 |
subtype2 | 11 | 3 |
subtype3 | 23 | 16 |
subtype4 | 19 | 8 |
subtype5 | 3 | 5 |
subtype6 | 11 | 4 |
P value = 0.262 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 67 | 73.6 (16.2) |
subtype1 | 6 | 85.0 (12.2) |
subtype2 | 8 | 66.2 (22.6) |
subtype3 | 26 | 70.4 (15.9) |
subtype4 | 18 | 75.6 (15.0) |
subtype5 | 4 | 77.5 (12.6) |
subtype6 | 5 | 78.0 (13.0) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 95 |
subtype1 | 74 | 0 |
subtype2 | 5 | 9 |
subtype3 | 0 | 42 |
subtype4 | 0 | 29 |
subtype5 | 4 | 5 |
subtype6 | 6 | 10 |
P value = 0.0686 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 34.7 (21.5) |
subtype1 | 34 | 41.7 (24.2) |
subtype2 | 3 | 14.5 (0.9) |
subtype3 | 27 | 29.3 (17.2) |
subtype4 | 16 | 30.1 (21.9) |
subtype5 | 3 | 41.2 (17.3) |
subtype6 | 14 | 36.5 (20.5) |
P value = 0.702 (Fisher's exact test), Q value = 0.75
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 136 | 13 | 2 | 7 |
subtype1 | 52 | 7 | 0 | 2 |
subtype2 | 11 | 0 | 0 | 0 |
subtype3 | 35 | 1 | 1 | 3 |
subtype4 | 22 | 3 | 1 | 1 |
subtype5 | 7 | 1 | 0 | 0 |
subtype6 | 9 | 1 | 0 | 1 |
P value = 0.283 (Kruskal-Wallis (anova)), Q value = 0.36
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 134 | 2.5 (3.4) |
subtype1 | 64 | 3.0 (4.0) |
subtype2 | 7 | 1.6 (1.5) |
subtype3 | 28 | 1.6 (2.6) |
subtype4 | 20 | 2.5 (2.1) |
subtype5 | 5 | 3.0 (6.2) |
subtype6 | 10 | 2.7 (2.9) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 5 | 113 |
subtype1 | 1 | 0 | 57 |
subtype2 | 6 | 0 | 7 |
subtype3 | 19 | 1 | 21 |
subtype4 | 17 | 3 | 8 |
subtype5 | 2 | 0 | 7 |
subtype6 | 1 | 1 | 13 |
P value = 0.404 (Fisher's exact test), Q value = 0.48
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 88 |
subtype1 | 2 | 17 |
subtype2 | 1 | 8 |
subtype3 | 0 | 27 |
subtype4 | 2 | 21 |
subtype5 | 0 | 6 |
subtype6 | 0 | 9 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 68 | 20 | 96 |
P value = 0.832 (logrank test), Q value = 0.87
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 184 | 77 | 0.1 - 122.1 (13.0) |
subtype1 | 68 | 34 | 1.4 - 122.1 (15.3) |
subtype2 | 20 | 10 | 0.4 - 54.0 (10.9) |
subtype3 | 96 | 33 | 0.1 - 68.0 (12.6) |
P value = 6.96e-06 (Kruskal-Wallis (anova)), Q value = 6e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 184 | 62.5 (11.9) |
subtype1 | 68 | 67.1 (11.7) |
subtype2 | 20 | 65.5 (13.3) |
subtype3 | 96 | 58.6 (10.5) |
P value = 2e-05 (Fisher's exact test), Q value = 1e-04
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 46 | 31 | 26 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 6 | 2 | 1 | 0 | 3 | 16 | 13 | 4 | 1 | 5 | 2 | 3 |
subtype2 | 2 | 0 | 1 | 0 | 2 | 2 | 1 | 1 | 3 | 0 | 0 | 0 |
subtype3 | 0 | 3 | 4 | 1 | 41 | 13 | 12 | 9 | 5 | 2 | 3 | 1 |
P value = 0.00177 (Fisher's exact test), Q value = 0.006
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 32 | 42 | 88 | 5 |
subtype1 | 18 | 9 | 30 | 1 |
subtype2 | 6 | 2 | 7 | 0 |
subtype3 | 8 | 31 | 51 | 4 |
P value = 0.0048 (Fisher's exact test), Q value = 0.014
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 76 | 69 | 12 | 8 |
subtype1 | 17 | 32 | 3 | 5 |
subtype2 | 5 | 7 | 3 | 0 |
subtype3 | 54 | 30 | 6 | 3 |
P value = 0.343 (Fisher's exact test), Q value = 0.43
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 42 | 5 |
subtype2 | 9 | 0 |
subtype3 | 84 | 4 |
P value = 0.91 (Fisher's exact test), Q value = 0.93
nPatients | FEMALE | MALE |
---|---|---|
ALL | 26 | 158 |
subtype1 | 10 | 58 |
subtype2 | 2 | 18 |
subtype3 | 14 | 82 |
P value = 0.00017 (Fisher's exact test), Q value = 0.00075
nPatients | NO | YES |
---|---|---|
ALL | 123 | 43 |
subtype1 | 48 | 9 |
subtype2 | 19 | 0 |
subtype3 | 56 | 34 |
P value = 0.0361 (Kruskal-Wallis (anova)), Q value = 0.076
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 67 | 73.6 (16.2) |
subtype1 | 6 | 85.0 (12.2) |
subtype2 | 1 | 90.0 (NA) |
subtype3 | 60 | 72.2 (16.2) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 95 |
subtype1 | 68 | 0 |
subtype2 | 20 | 0 |
subtype3 | 1 | 95 |
P value = 0.125 (Kruskal-Wallis (anova)), Q value = 0.2
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 34.7 (21.5) |
subtype1 | 27 | 37.6 (25.6) |
subtype2 | 14 | 43.8 (21.9) |
subtype3 | 56 | 31.0 (18.6) |
P value = 0.14 (Fisher's exact test), Q value = 0.21
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 136 | 13 | 2 | 7 |
subtype1 | 46 | 8 | 0 | 1 |
subtype2 | 12 | 0 | 0 | 2 |
subtype3 | 78 | 5 | 2 | 4 |
P value = 0.0507 (Kruskal-Wallis (anova)), Q value = 0.099
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 134 | 2.5 (3.4) |
subtype1 | 56 | 3.5 (4.4) |
subtype2 | 15 | 1.7 (2.1) |
subtype3 | 63 | 1.9 (2.4) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 5 | 113 |
subtype1 | 1 | 0 | 54 |
subtype2 | 0 | 0 | 17 |
subtype3 | 45 | 5 | 42 |
P value = 0.173 (Fisher's exact test), Q value = 0.25
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 88 |
subtype1 | 2 | 14 |
subtype2 | 1 | 9 |
subtype3 | 2 | 65 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
Number of samples | 71 | 15 | 10 | 18 | 28 | 42 |
P value = 0.0806 (logrank test), Q value = 0.14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 184 | 77 | 0.1 - 122.1 (13.2) |
subtype1 | 71 | 35 | 0.4 - 122.1 (14.3) |
subtype2 | 15 | 9 | 0.1 - 52.3 (10.8) |
subtype3 | 10 | 6 | 1.4 - 44.8 (5.3) |
subtype4 | 18 | 6 | 5.3 - 58.6 (12.8) |
subtype5 | 28 | 8 | 0.3 - 83.2 (14.2) |
subtype6 | 42 | 13 | 0.8 - 68.0 (13.0) |
P value = 0.00418 (Kruskal-Wallis (anova)), Q value = 0.012
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 184 | 62.5 (11.9) |
subtype1 | 71 | 66.0 (11.6) |
subtype2 | 15 | 58.7 (12.1) |
subtype3 | 10 | 63.5 (12.5) |
subtype4 | 18 | 60.8 (10.9) |
subtype5 | 28 | 63.9 (13.4) |
subtype6 | 42 | 57.6 (9.8) |
P value = 1e-04 (Fisher's exact test), Q value = 0.00047
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 46 | 31 | 26 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 8 | 2 | 2 | 0 | 3 | 13 | 12 | 2 | 4 | 4 | 1 | 3 |
subtype2 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 1 | 0 | 2 | 1 | 0 |
subtype3 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 1 | 0 | 1 | 0 |
subtype4 | 0 | 2 | 0 | 1 | 10 | 2 | 1 | 0 | 1 | 0 | 0 | 0 |
subtype5 | 0 | 1 | 1 | 0 | 8 | 8 | 3 | 5 | 0 | 1 | 0 | 1 |
subtype6 | 0 | 0 | 3 | 0 | 20 | 5 | 5 | 4 | 3 | 0 | 2 | 0 |
P value = 8e-04 (Fisher's exact test), Q value = 0.0029
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 32 | 43 | 87 | 5 |
subtype1 | 21 | 6 | 31 | 0 |
subtype2 | 0 | 2 | 9 | 1 |
subtype3 | 1 | 2 | 6 | 0 |
subtype4 | 4 | 7 | 7 | 0 |
subtype5 | 3 | 10 | 13 | 2 |
subtype6 | 3 | 16 | 21 | 2 |
P value = 0.00754 (Fisher's exact test), Q value = 0.021
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 76 | 69 | 12 | 8 |
subtype1 | 19 | 30 | 5 | 4 |
subtype2 | 5 | 5 | 0 | 2 |
subtype3 | 1 | 5 | 2 | 1 |
subtype4 | 13 | 4 | 1 | 0 |
subtype5 | 13 | 13 | 0 | 1 |
subtype6 | 25 | 12 | 4 | 0 |
P value = 0.618 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 41 | 4 |
subtype2 | 10 | 1 |
subtype3 | 6 | 1 |
subtype4 | 16 | 0 |
subtype5 | 25 | 1 |
subtype6 | 37 | 2 |
P value = 0.379 (Fisher's exact test), Q value = 0.46
nPatients | FEMALE | MALE |
---|---|---|
ALL | 27 | 157 |
subtype1 | 10 | 61 |
subtype2 | 0 | 15 |
subtype3 | 1 | 9 |
subtype4 | 5 | 13 |
subtype5 | 4 | 24 |
subtype6 | 7 | 35 |
P value = 0.00466 (Fisher's exact test), Q value = 0.013
nPatients | NO | YES |
---|---|---|
ALL | 124 | 42 |
subtype1 | 54 | 7 |
subtype2 | 8 | 6 |
subtype3 | 8 | 1 |
subtype4 | 14 | 3 |
subtype5 | 15 | 10 |
subtype6 | 25 | 15 |
P value = 0.327 (Kruskal-Wallis (anova)), Q value = 0.41
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 67 | 74.0 (16.2) |
subtype1 | 5 | 84.0 (13.4) |
subtype2 | 8 | 80.0 (10.7) |
subtype3 | 3 | 76.7 (15.3) |
subtype4 | 10 | 64.0 (22.2) |
subtype5 | 14 | 72.9 (17.3) |
subtype6 | 27 | 74.4 (14.2) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 95 |
subtype1 | 71 | 0 |
subtype2 | 4 | 11 |
subtype3 | 5 | 5 |
subtype4 | 2 | 16 |
subtype5 | 7 | 21 |
subtype6 | 0 | 42 |
P value = 0.194 (Kruskal-Wallis (anova)), Q value = 0.26
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 34.7 (21.5) |
subtype1 | 33 | 41.3 (24.8) |
subtype2 | 12 | 25.7 (12.0) |
subtype3 | 5 | 28.0 (12.0) |
subtype4 | 8 | 33.4 (13.1) |
subtype5 | 14 | 40.6 (25.4) |
subtype6 | 25 | 28.6 (19.5) |
P value = 0.187 (Fisher's exact test), Q value = 0.26
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 136 | 13 | 2 | 7 |
subtype1 | 47 | 6 | 0 | 3 |
subtype2 | 8 | 3 | 0 | 0 |
subtype3 | 7 | 0 | 0 | 1 |
subtype4 | 17 | 0 | 0 | 0 |
subtype5 | 22 | 3 | 0 | 0 |
subtype6 | 35 | 1 | 2 | 3 |
P value = 0.00193 (Kruskal-Wallis (anova)), Q value = 0.0064
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 2.5 (3.4) |
subtype1 | 58 | 3.2 (4.1) |
subtype2 | 8 | 4.5 (2.9) |
subtype3 | 8 | 4.1 (2.8) |
subtype4 | 10 | 1.1 (1.6) |
subtype5 | 21 | 2.0 (3.4) |
subtype6 | 30 | 1.2 (1.6) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 45 | 5 | 114 |
subtype1 | 1 | 0 | 56 |
subtype2 | 3 | 3 | 6 |
subtype3 | 3 | 0 | 6 |
subtype4 | 10 | 0 | 7 |
subtype5 | 9 | 1 | 17 |
subtype6 | 19 | 1 | 22 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 87 |
subtype1 | 2 | 20 |
subtype2 | 0 | 7 |
subtype3 | 0 | 4 |
subtype4 | 1 | 14 |
subtype5 | 1 | 15 |
subtype6 | 2 | 27 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 63 | 26 | 62 | 33 |
P value = 0.0182 (logrank test), Q value = 0.043
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 184 | 77 | 0.1 - 122.1 (13.2) |
subtype1 | 63 | 38 | 0.4 - 122.1 (13.5) |
subtype2 | 26 | 7 | 3.0 - 83.2 (19.1) |
subtype3 | 62 | 22 | 0.1 - 35.2 (12.5) |
subtype4 | 33 | 10 | 0.8 - 68.0 (15.5) |
P value = 1.85e-06 (Kruskal-Wallis (anova)), Q value = 6e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 184 | 62.5 (11.9) |
subtype1 | 63 | 65.1 (11.9) |
subtype2 | 26 | 71.2 (11.5) |
subtype3 | 62 | 58.1 (11.1) |
subtype4 | 33 | 59.3 (8.6) |
P value = 2e-05 (Fisher's exact test), Q value = 1e-04
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 46 | 31 | 26 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 7 | 2 | 2 | 0 | 1 | 11 | 12 | 2 | 3 | 3 | 1 | 3 |
subtype2 | 1 | 0 | 0 | 0 | 4 | 7 | 3 | 3 | 1 | 2 | 1 | 0 |
subtype3 | 0 | 2 | 2 | 1 | 24 | 9 | 9 | 6 | 4 | 2 | 1 | 0 |
subtype4 | 0 | 1 | 2 | 0 | 17 | 4 | 2 | 3 | 1 | 0 | 2 | 1 |
P value = 0.00089 (Fisher's exact test), Q value = 0.0032
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 32 | 43 | 87 | 5 |
subtype1 | 19 | 8 | 23 | 0 |
subtype2 | 5 | 3 | 15 | 1 |
subtype3 | 4 | 21 | 31 | 4 |
subtype4 | 4 | 11 | 18 | 0 |
P value = 0.0434 (Fisher's exact test), Q value = 0.09
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 76 | 69 | 12 | 8 |
subtype1 | 14 | 29 | 4 | 3 |
subtype2 | 8 | 11 | 2 | 2 |
subtype3 | 33 | 19 | 5 | 2 |
subtype4 | 21 | 10 | 1 | 1 |
P value = 0.204 (Fisher's exact test), Q value = 0.27
nPatients | 0 | 1 |
---|---|---|
ALL | 135 | 9 |
subtype1 | 33 | 4 |
subtype2 | 19 | 1 |
subtype3 | 55 | 1 |
subtype4 | 28 | 3 |
P value = 0.488 (Fisher's exact test), Q value = 0.55
nPatients | FEMALE | MALE |
---|---|---|
ALL | 27 | 157 |
subtype1 | 7 | 56 |
subtype2 | 5 | 21 |
subtype3 | 8 | 54 |
subtype4 | 7 | 26 |
P value = 0.00105 (Fisher's exact test), Q value = 0.0037
nPatients | NO | YES |
---|---|---|
ALL | 124 | 42 |
subtype1 | 49 | 6 |
subtype2 | 19 | 3 |
subtype3 | 34 | 24 |
subtype4 | 22 | 9 |
P value = 0.116 (Kruskal-Wallis (anova)), Q value = 0.19
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 67 | 74.0 (16.2) |
subtype1 | 6 | 85.0 (12.2) |
subtype2 | 1 | 90.0 (NA) |
subtype3 | 37 | 72.4 (15.5) |
subtype4 | 23 | 73.0 (17.7) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 95 |
subtype1 | 63 | 0 |
subtype2 | 26 | 0 |
subtype3 | 0 | 62 |
subtype4 | 0 | 33 |
P value = 0.136 (Kruskal-Wallis (anova)), Q value = 0.21
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 34.7 (21.5) |
subtype1 | 28 | 35.7 (20.2) |
subtype2 | 13 | 48.5 (30.4) |
subtype3 | 35 | 33.3 (19.0) |
subtype4 | 21 | 27.1 (17.7) |
P value = 0.679 (Fisher's exact test), Q value = 0.73
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 136 | 13 | 2 | 7 |
subtype1 | 41 | 5 | 0 | 1 |
subtype2 | 18 | 3 | 0 | 2 |
subtype3 | 48 | 3 | 2 | 2 |
subtype4 | 29 | 2 | 0 | 2 |
P value = 0.21 (Kruskal-Wallis (anova)), Q value = 0.28
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 2.5 (3.4) |
subtype1 | 49 | 2.9 (3.3) |
subtype2 | 23 | 3.5 (5.4) |
subtype3 | 40 | 1.8 (2.2) |
subtype4 | 23 | 2.0 (2.8) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 45 | 5 | 114 |
subtype1 | 1 | 0 | 49 |
subtype2 | 0 | 0 | 22 |
subtype3 | 30 | 4 | 26 |
subtype4 | 14 | 1 | 17 |
P value = 0.176 (Fisher's exact test), Q value = 0.25
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 87 |
subtype1 | 3 | 17 |
subtype2 | 0 | 6 |
subtype3 | 1 | 46 |
subtype4 | 2 | 18 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 65 | 67 | 35 | 12 |
P value = 0.0448 (logrank test), Q value = 0.091
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 179 | 77 | 0.1 - 122.1 (13.2) |
subtype1 | 65 | 35 | 0.4 - 122.1 (13.9) |
subtype2 | 67 | 25 | 0.1 - 68.0 (12.7) |
subtype3 | 35 | 11 | 0.3 - 83.2 (15.5) |
subtype4 | 12 | 6 | 0.8 - 19.7 (8.2) |
P value = 8.25e-06 (Kruskal-Wallis (anova)), Q value = 6e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 179 | 62.5 (12.0) |
subtype1 | 65 | 66.4 (12.2) |
subtype2 | 67 | 56.8 (9.7) |
subtype3 | 35 | 65.5 (12.7) |
subtype4 | 12 | 64.8 (9.0) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 7 | 5 | 5 | 1 | 46 | 30 | 25 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 7 | 2 | 2 | 0 | 2 | 12 | 12 | 3 | 3 | 2 | 2 | 3 |
subtype2 | 0 | 2 | 2 | 1 | 31 | 7 | 8 | 3 | 5 | 2 | 3 | 1 |
subtype3 | 0 | 1 | 1 | 0 | 12 | 9 | 3 | 5 | 1 | 2 | 0 | 0 |
subtype4 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 3 | 0 | 1 | 0 | 0 |
P value = 0.00078 (Fisher's exact test), Q value = 0.0029
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 31 | 42 | 85 | 5 |
subtype1 | 20 | 8 | 27 | 0 |
subtype2 | 7 | 22 | 35 | 1 |
subtype3 | 4 | 9 | 19 | 2 |
subtype4 | 0 | 3 | 4 | 2 |
P value = 0.104 (Fisher's exact test), Q value = 0.17
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 73 | 68 | 12 | 8 |
subtype1 | 16 | 32 | 5 | 2 |
subtype2 | 35 | 21 | 5 | 3 |
subtype3 | 18 | 12 | 1 | 2 |
subtype4 | 4 | 3 | 1 | 1 |
P value = 0.235 (Fisher's exact test), Q value = 0.31
nPatients | 0 | 1 |
---|---|---|
ALL | 132 | 9 |
subtype1 | 36 | 5 |
subtype2 | 57 | 4 |
subtype3 | 31 | 0 |
subtype4 | 8 | 0 |
P value = 0.987 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 25 | 154 |
subtype1 | 10 | 55 |
subtype2 | 9 | 58 |
subtype3 | 5 | 30 |
subtype4 | 1 | 11 |
P value = 0.00317 (Fisher's exact test), Q value = 0.0097
nPatients | NO | YES |
---|---|---|
ALL | 122 | 40 |
subtype1 | 51 | 6 |
subtype2 | 40 | 22 |
subtype3 | 21 | 11 |
subtype4 | 10 | 1 |
P value = 0.0292 (Kruskal-Wallis (anova)), Q value = 0.066
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 65 | 74.2 (16.4) |
subtype1 | 6 | 85.0 (12.2) |
subtype2 | 40 | 71.5 (16.7) |
subtype3 | 13 | 71.5 (16.8) |
subtype4 | 6 | 86.7 (5.2) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 87 | 92 |
subtype1 | 65 | 0 |
subtype2 | 1 | 66 |
subtype3 | 16 | 19 |
subtype4 | 5 | 7 |
P value = 0.0166 (Kruskal-Wallis (anova)), Q value = 0.04
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 94 | 35.1 (21.6) |
subtype1 | 31 | 36.7 (19.2) |
subtype2 | 40 | 27.0 (16.1) |
subtype3 | 18 | 47.2 (27.5) |
subtype4 | 5 | 45.6 (29.9) |
P value = 0.127 (Fisher's exact test), Q value = 0.2
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 132 | 13 | 2 | 7 |
subtype1 | 44 | 6 | 0 | 2 |
subtype2 | 57 | 2 | 1 | 3 |
subtype3 | 23 | 5 | 0 | 1 |
subtype4 | 8 | 0 | 1 | 1 |
P value = 0.158 (Kruskal-Wallis (anova)), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 132 | 2.6 (3.4) |
subtype1 | 54 | 2.8 (3.0) |
subtype2 | 41 | 2.5 (2.7) |
subtype3 | 27 | 2.1 (4.6) |
subtype4 | 10 | 3.1 (4.8) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 44 | 4 | 111 |
subtype1 | 1 | 0 | 49 |
subtype2 | 36 | 3 | 24 |
subtype3 | 6 | 1 | 27 |
subtype4 | 1 | 0 | 11 |
P value = 0.418 (Fisher's exact test), Q value = 0.49
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 84 |
subtype1 | 2 | 16 |
subtype2 | 2 | 45 |
subtype3 | 1 | 17 |
subtype4 | 1 | 6 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 56 | 29 | 94 |
P value = 0.0328 (logrank test), Q value = 0.071
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 179 | 77 | 0.1 - 122.1 (13.2) |
subtype1 | 56 | 36 | 1.4 - 122.1 (13.4) |
subtype2 | 29 | 9 | 0.4 - 83.2 (18.2) |
subtype3 | 94 | 32 | 0.1 - 68.0 (12.7) |
P value = 7.31e-07 (Kruskal-Wallis (anova)), Q value = 6e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 179 | 62.5 (12.0) |
subtype1 | 56 | 65.0 (12.1) |
subtype2 | 29 | 70.7 (10.8) |
subtype3 | 94 | 58.6 (10.7) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 7 | 5 | 5 | 1 | 46 | 30 | 25 | 14 | 9 | 7 | 5 | 4 |
subtype1 | 5 | 2 | 2 | 0 | 1 | 10 | 11 | 2 | 3 | 3 | 1 | 3 |
subtype2 | 2 | 0 | 0 | 0 | 4 | 7 | 4 | 2 | 1 | 2 | 1 | 0 |
subtype3 | 0 | 3 | 3 | 1 | 41 | 13 | 10 | 10 | 5 | 2 | 3 | 1 |
P value = 0.00058 (Fisher's exact test), Q value = 0.0023
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 31 | 42 | 85 | 5 |
subtype1 | 16 | 7 | 22 | 0 |
subtype2 | 7 | 3 | 16 | 0 |
subtype3 | 8 | 32 | 47 | 5 |
P value = 0.00997 (Fisher's exact test), Q value = 0.026
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 73 | 68 | 12 | 8 |
subtype1 | 11 | 27 | 4 | 3 |
subtype2 | 10 | 12 | 2 | 2 |
subtype3 | 52 | 29 | 6 | 3 |
P value = 0.372 (Fisher's exact test), Q value = 0.46
nPatients | 0 | 1 |
---|---|---|
ALL | 132 | 9 |
subtype1 | 29 | 4 |
subtype2 | 21 | 1 |
subtype3 | 82 | 4 |
P value = 0.392 (Fisher's exact test), Q value = 0.47
nPatients | FEMALE | MALE |
---|---|---|
ALL | 25 | 154 |
subtype1 | 5 | 51 |
subtype2 | 5 | 24 |
subtype3 | 15 | 79 |
P value = 0.00364 (Fisher's exact test), Q value = 0.011
nPatients | NO | YES |
---|---|---|
ALL | 122 | 40 |
subtype1 | 44 | 6 |
subtype2 | 21 | 3 |
subtype3 | 57 | 31 |
P value = 0.0516 (Kruskal-Wallis (anova)), Q value = 0.099
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 65 | 74.2 (16.4) |
subtype1 | 6 | 85.0 (12.2) |
subtype3 | 59 | 73.1 (16.4) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 87 | 92 |
subtype1 | 56 | 0 |
subtype2 | 29 | 0 |
subtype3 | 2 | 92 |
P value = 0.0185 (Kruskal-Wallis (anova)), Q value = 0.043
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 94 | 35.1 (21.6) |
subtype1 | 24 | 35.2 (19.9) |
subtype2 | 15 | 50.9 (27.1) |
subtype3 | 55 | 30.7 (18.9) |
P value = 0.669 (Fisher's exact test), Q value = 0.73
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 132 | 13 | 2 | 7 |
subtype1 | 36 | 5 | 0 | 1 |
subtype2 | 21 | 3 | 0 | 2 |
subtype3 | 75 | 5 | 2 | 4 |
P value = 0.0665 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 132 | 2.6 (3.4) |
subtype1 | 44 | 3.1 (3.4) |
subtype2 | 26 | 3.3 (5.1) |
subtype3 | 62 | 1.9 (2.4) |
P value = 1e-05 (Fisher's exact test), Q value = 6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 44 | 4 | 111 |
subtype1 | 1 | 0 | 43 |
subtype2 | 0 | 0 | 24 |
subtype3 | 43 | 4 | 44 |
P value = 0.141 (Fisher's exact test), Q value = 0.21
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 84 |
subtype1 | 3 | 15 |
subtype2 | 0 | 6 |
subtype3 | 3 | 63 |
-
Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/ESCA-TP/22541001/ESCA-TP.mergedcluster.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/ESCA-TP/22506419/ESCA-TP.merged_data.txt
-
Number of patients = 185
-
Number of clustering approaches = 10
-
Number of selected clinical features = 15
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.