Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	153 (83%)	32	9.9999e-06	0.002	5e-05	0.00429	0.14103	0.661	0.13424	0.651	0.03031	0.357	0.0076099	0.145	0.39979	0.838	0.02661	0.34	0.00287	0.082	0.03245	0.367
SMAD4	13 (7%)	172	0.02839	0.348	0.34992	0.824	0.27341	0.787	0.11513	0.625	0.53257	0.927	0.065949	0.489	0.55517	0.936	0.15989	0.662	0.57222	0.949	0.11427	0.625
CDKN2A	19 (10%)	166	0.2244	0.744	0.62582	0.963	0.92128	1	0.62119	0.963	0.1399	0.661	0.0061599	0.124	0.36177	0.834	0.10465	0.618	0.67167	0.964	0.0411	0.388
NFE2L2	16 (9%)	169	2e-05	0.0024	9.9999e-06	0.002	0.094359	0.587	0.34085	0.819	9.9999e-06	0.002	0.0019	0.06	0.00305	0.0832	0.00099999	0.0408	2e-05	0.0024	0.00184	0.06
MLL2	32 (17%)	153	0.66553	0.964	0.28949	0.808	0.04092	0.388	0.39678	0.838	0.49516	0.898	0.15757	0.661	0.10144	0.615	0.13017	0.651	0.061029	0.469	0.26041	0.781
ZNF750	10 (5%)	175	0.083429	0.569	0.20374	0.713	0.33066	0.816	0.45934	0.872	0.17609	0.69	0.0199	0.284	0.01885	0.283	4e-05	0.004	0.065489	0.489	0.02917	0.35
TGFBR2	15 (8%)	170	0.02308	0.316	0.25767	0.781	0.74305	0.99	0.26326	0.786	0.7841	0.994	0.53307	0.927	0.79666	0.994	0.92615	1	1	1	1	1
FBXW7	13 (7%)	172	0.18691	0.705	0.43385	0.856	0.65492	0.963	0.59599	0.963	0.11917	0.625	0.1194	0.625	0.31453	0.81	0.27569	0.787	0.32537	0.812	0.22372	0.744
PKD2	7 (4%)	178	0.39575	0.838	0.13555	0.651	0.78149	0.994	0.04044	0.388	0.33225	0.817	0.63431	0.963	0.23285	0.747	0.13142	0.651	0.11971	0.625	0.16766	0.684
ARID1A	15 (8%)	170	0.03738	0.387	0.21822	0.736	0.0043	0.0956	0.03547	0.378	0.078109	0.551	0.0077199	0.145	0.11935	0.625	0.0359	0.378	0.14634	0.661	0.0117	0.195
ERBB2	11 (6%)	174	0.04269	0.388	0.01049	0.18	NA	NA	NA	NA	0.02317	0.316	0.00032	0.0191	0.02823	0.348	0.00142	0.0532	0.00403	0.0956	0.00048	0.024
PTCH1	12 (6%)	173	0.04131	0.388	0.2524	0.777	0.40376	0.838	0.95764	1	0.087539	0.571	0.34126	0.819	0.37788	0.838	0.32247	0.812	0.20425	0.713	0.39153	0.838
KIAA2018	13 (7%)	172	0.23585	0.749	0.59831	0.963	0.22581	0.744	0.19765	0.713	0.55384	0.936	0.22687	0.744	0.38826	0.838	0.2208	0.74	0.63939	0.963	0.1281	0.646
FAM108A1	4 (2%)	181	0.82884	0.995	0.59009	0.957	0.20256	0.713	0.54144	0.934	0.63446	0.963	0.56587	0.946	0.2682	0.787	0.74811	0.99	0.75762	0.99	0.81773	0.994
PAXIP1	10 (5%)	175	0.6884	0.967	0.9421	1	0.5501	0.936	0.86541	1	0.28848	0.808	0.89515	1	0.14726	0.661	0.057799	0.462	0.2973	0.808	1	1
MGC29506	4 (2%)	181	0.30086	0.808	1	1	NA	NA	NA	NA	0.3235	0.812	1	1	0.41099	0.839	0.21576	0.731	0.7621	0.99	0.64682	0.963
C10ORF76	6 (3%)	179	0.03237	0.367	0.77738	0.994	0.55453	0.936	0.46912	0.882	0.48314	0.889	1	1	0.81062	0.994	0.34375	0.822	0.25593	0.781	0.57164	0.949
IPP	6 (3%)	179	0.86901	1	0.81378	0.994	0.42298	0.851	0.49377	0.898	0.35696	0.83	0.8495	1	0.11556	0.625	0.36432	0.834	0.34753	0.824	0.24309	0.763
DNAH10	19 (10%)	166	0.85604	1	0.42453	0.851	0.4127	0.839	0.29802	0.808	0.37606	0.838	0.15056	0.661	0.31017	0.808	0.599	0.963	0.60562	0.963	0.41523	0.839
RIC3	4 (2%)	181	0.3029	0.808	0.32602	0.812	1	1	0.82269	0.995	0.92854	1	0.43353	0.856	1	1	0.67399	0.964	0.87646	1	0.48466	0.889
HMMR	4 (2%)	181	0.1049	0.618	0.30664	0.808	0.64244	0.963	0.51909	0.919	0.87057	1	1	1	1	1	1	1	0.87799	1	0.81729	0.994
PIAS1	5 (3%)	180	0.33619	0.819	0.7855	0.994	0.55753	0.937	0.13785	0.656	0.20554	0.713	0.80322	0.994	0.50946	0.912	0.64805	0.963	0.81309	0.994	0.70447	0.974
ITGA6	7 (4%)	178	0.87761	1	0.3712	0.838	0.35611	0.83	0.84735	1	0.52701	0.927	1	1	0.914	1	0.94863	1	0.92935	1	1	1
ASTE1	5 (3%)	180	0.082769	0.569	0.060539	0.469	0.75308	0.99	0.36044	0.834	0.43552	0.857	0.01477	0.233	0.60905	0.963	0.00161	0.0568	0.082819	0.569	0.00102	0.0408
KPNA1	6 (3%)	179	0.49102	0.898	0.72681	0.98	0.45738	0.872	0.069539	0.509	0.19691	0.713	0.84683	1	0.22883	0.746	0.75439	0.99	1	1	0.3065	0.808
LIMA1	8 (4%)	177	0.63917	0.963	0.67585	0.964	0.35034	0.824	0.13527	0.651	0.42548	0.851	0.10064	0.615	0.29789	0.808	0.12709	0.646	0.15521	0.661	0.13423	0.651
FAM65B	8 (4%)	177	1	1	0.66493	0.964	0.38853	0.838	0.28635	0.807	0.927	1	0.88016	1	0.17642	0.69	0.0425	0.388	0.68602	0.967	0.38005	0.838
CORO7	7 (4%)	178	0.23465	0.749	0.37667	0.838	0.61426	0.963	0.15569	0.661	0.49717	0.898	0.2089	0.72	0.28251	0.8	0.03563	0.378	0.02372	0.316	0.15906	0.662
ANAPC1	5 (3%)	180	0.00016	0.012	0.31069	0.808	0.6757	0.964	0.45624	0.872	0.76301	0.99	0.80422	0.994	0.89189	1	0.17552	0.69	0.87946	1	0.64663	0.963
IVL	15 (8%)	170	0.0057899	0.124	0.02446	0.319	0.1569	0.661	0.00388	0.0956	0.00351	0.0916	0.00019	0.0127	0.03952	0.388	0.00075999	0.0351	0.0081899	0.149	0.00035	0.0191
PIK3CA	19 (10%)	166	0.50483	0.907	0.27131	0.787	0.25208	0.777	0.30366	0.808	0.15413	0.661	0.4814	0.889	0.17703	0.69	0.32921	0.816	0.10512	0.618	0.24885	0.774
RB1	7 (4%)	178	0.00242	0.0726	0.97383	1	0.3897	0.838	0.40764	0.838	0.7877	0.994	0.86725	1	0.67319	0.964	0.89977	1	0.45291	0.872	1	1
EIF4EBP2	3 (2%)	182	0.04403	0.394	0.55327	0.936	NA	NA	NA	NA	0.72606	0.98	0.076099	0.544	0.69026	0.967	0.21239	0.728	0.052319	0.442	0.14511	0.661
SCD	3 (2%)	182	0.58242	0.95	0.76699	0.99	NA	NA	NA	NA	0.80118	0.994	0.69627	0.967	0.57938	0.95	0.63932	0.963	0.68583	0.967	0.74107	0.99
MKL2	6 (3%)	179	0.10641	0.619	0.30893	0.808	0.4987	0.899	0.76709	0.99	0.66391	0.964	0.15383	0.661	0.62994	0.963	0.31982	0.812	0.40402	0.838	0.11384	0.625
NOTCH1	18 (10%)	167	0.057619	0.462	0.00426	0.0956	0.15651	0.661	0.092049	0.583	0.059029	0.466	0.088889	0.573	0.01791	0.276	0.0093099	0.164	0.054859	0.457	0.061979	0.471
KLF3	3 (2%)	182	0.04226	0.388	0.1686	0.684	NA	NA	NA	NA	0.72436	0.98	0.1242	0.642	0.68713	0.967	0.31228	0.808	0.45418	0.872	0.14421	0.661
IL10RA	3 (2%)	182	0.78858	0.994	1	1	0.75397	0.99	0.35673	0.83	0.51052	0.912	0.69507	0.967	0.8153	0.994	0.87475	1	0.68587	0.967	0.74077	0.99
RAD17	4 (2%)	181	1	1	0.23065	0.746	0.38154	0.838	0.63376	0.963	0.63343	0.963	0.77442	0.993	0.25932	0.781	0.0061799	0.124	0.17779	0.69	0.38281	0.838
KPNB1	6 (3%)	179	0.18367	0.702	0.087459	0.571	0.30762	0.808	0.65669	0.963	0.34826	0.824	0.39055	0.838	0.18069	0.695	0.6981	0.967	0.8895	1	0.57415	0.949
ZBED4	5 (3%)	180	0.40505	0.838	0.64029	0.963	0.36265	0.834	0.80075	0.994	0.03457	0.378	0.66827	0.964	0.094959	0.587	0.48267	0.889	0.88842	1	0.57334	0.949
NAA16	6 (3%)	179	0.87054	1	0.4844	0.889	0.64293	0.963	0.45945	0.872	0.44247	0.865	0.23121	0.746	0.90344	1	0.092369	0.583	0.27052	0.787	0.38189	0.838
CNNM2	7 (4%)	178	0.77965	0.994	0.81166	0.994	0.2767	0.787	0.20188	0.713	0.88478	1	0.2056	0.713	0.62964	0.963	0.58221	0.95	0.76325	0.99	0.27589	0.787
HLA-B	7 (4%)	178	0.01956	0.284	0.93713	1	0.27491	0.787	0.32234	0.812	0.65429	0.963	1	1	0.46886	0.882	0.24421	0.763	0.76908	0.99	0.63028	0.963
PLXNB2	12 (6%)	173	0.53057	0.927	0.87813	1	0.89915	1	0.65567	0.963	0.86847	1	0.91181	1	0.87864	1	0.78745	0.994	0.82677	0.995	1	1
PTEN	7 (4%)	178	0.69335	0.967	0.60234	0.963	0.4669	0.882	0.20417	0.713	0.75026	0.99	0.43352	0.856	0.37169	0.838	0.72525	0.98	0.54649	0.936	0.7404	0.99
CPT1B	5 (3%)	180	0.6103	0.963	0.87044	1	0.39874	0.838	0.55892	0.937	0.818	0.994	1	1	0.92311	1	1	1	0.45187	0.872	0.84832	1
CAMTA1	9 (5%)	176	0.54002	0.934	0.11854	0.625	0.1094	0.619	0.04739	0.414	0.85698	1	0.41513	0.839	0.14932	0.661	0.76194	0.99	0.65234	0.963	0.62675	0.963
OTUD7B	7 (4%)	178	0.10751	0.619	0.38896	0.838	1	1	0.87104	1	0.33588	0.819	0.5247	0.926	0.40095	0.838	1	1	0.47748	0.889	0.86846	1
ARRB1	5 (3%)	180	0.72332	0.98	0.38371	0.838	0.5494	0.936	0.19105	0.708	0.41273	0.839	0.10853	0.619	0.66162	0.964	0.74726	0.99	0.8114	0.994	0.45258	0.872
KIAA1704	3 (2%)	182	0.084409	0.569	0.76637	0.99	NA	NA	NA	NA	0.80152	0.994	0.69748	0.967	1	1	0.87535	1	0.68336	0.967	0.57825	0.95
RNF169	6 (3%)	179	0.49223	0.898	0.9805	1	0.71523	0.978	0.40626	0.838	0.96694	1	0.30416	0.808	1	1	0.51592	0.916	0.83638	1	0.3109	0.808
RBPJL	6 (3%)	179	0.64507	0.963	0.19391	0.713	0.17825	0.69	0.16586	0.682	0.33975	0.819	1	1	0.79563	0.994	0.715	0.978	1	1	0.73976	0.99
MGAT5B	8 (4%)	177	0.70736	0.976	0.25839	0.781	0.9263	1	0.6312	0.963	0.51609	0.916	1	1	0.98558	1	0.65157	0.963	0.12591	0.646	0.32276	0.812
LRRC32	9 (5%)	176	0.19546	0.713	0.37062	0.838	0.57838	0.95	0.92022	1	1	1	0.47256	0.883	0.72396	0.98	0.80634	0.994	0.45177	0.872	0.81194	0.994
TCHH	14 (8%)	171	0.44071	0.864	0.01464	0.233	0.53186	0.927	0.77269	0.993	0.30948	0.808	0.55441	0.936	0.61897	0.963	0.31813	0.812	0.89512	1	0.62643	0.963
SLC22A2	4 (2%)	181	0.18525	0.703	0.38937	0.838	NA	NA	NA	NA	0.29646	0.808	0.43196	0.856	0.76068	0.99	0.54172	0.934	0.27358	0.787	0.21476	0.731
PCDH15	21 (11%)	164	0.71421	0.978	0.82015	0.994	0.64168	0.963	0.39744	0.838	0.40639	0.838	0.14211	0.661	0.92639	1	0.19103	0.708	0.60639	0.963	0.33818	0.819
KIAA1549	8 (4%)	177	0.057119	0.462	0.82643	0.995	0.23793	0.751	0.82711	0.995	0.67659	0.964	0.67133	0.964	0.98501	1	0.95408	1	0.71555	0.978	0.86681	1
SETBP1	14 (8%)	171	0.58407	0.95	0.18896	0.708	0.47064	0.882	0.04764	0.414	0.071699	0.518	0.086519	0.571	0.27676	0.787	0.17041	0.686	0.04825	0.414	0.15015	0.661