rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(19), E2F1(2), MDM2(2), PIK3CA(21), PIK3R1(5), POLR1A(4), POLR1B(3), POLR1C(5), RAC1(1), RB1(8), TBX2(2), TP53(174), TWIST1(2) 5500423 250 165 171 15 53 53 23 23 95 3 1.34e-14 <1.00e-15 <6.31e-14 2 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(4), DLD(4), DUSP10(3), DUSP4(1), GAB1(1), GCK(1), IL1R1(1), JUN(1), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(1), MAPK9(2), MYEF2(2), NFATC3(2), NR2C2(4), PAPPA(6), TP53(174), TRAF6(1), ZAK(4) 13707275 263 163 192 23 66 56 25 27 86 3 9.94e-12 <1.00e-15 <6.31e-14 3 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(22), BRCA1(6), CDKN1A(2), CHEK1(1), CHEK2(3), JUN(1), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(2), RAD50(3), RAD51(3), RBBP8(3), TP53(174), TP73(3) 8026064 230 161 157 10 53 51 22 24 77 3 1.18e-14 <1.00e-15 <6.31e-14 4 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(1), IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(2), NFKB1(2), RB1(8), TNFRSF1B(1), TP53(174), WT1(4) 5099114 200 161 130 12 52 33 19 18 75 3 8.62e-13 <1.00e-15 <6.31e-14 5 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(22), ATR(5), BRCA1(6), BRCA2(9), CHEK1(1), CHEK2(3), FANCA(5), FANCC(2), FANCD2(4), FANCF(1), FANCG(1), MRE11A(2), RAD17(4), RAD50(3), RAD51(3), TP53(174), TREX1(1) 11882135 246 160 174 14 53 52 29 26 83 3 1.64e-12 <1.00e-15 <6.31e-14 6 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(22), CDC25A(3), CDC25B(2), CDK2(1), CHEK1(1), MYT1(4), RB1(8), TP53(174), WEE1(1) 4826897 216 160 146 6 51 44 21 19 78 3 <1.00e-15 <1.00e-15 <6.31e-14 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDK2(1), CDKN1A(2), CDKN2A(19), CFL1(1), E2F1(2), E2F2(2), MDM2(2), NXT1(1), PRB1(2), TP53(174) 2257529 208 159 137 5 51 37 18 19 80 3 <1.00e-15 <1.00e-15 <6.31e-14 8 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(13), DAXX(3), HRAS(1), PML(4), RB1(8), SIRT1(5), SP100(7), TNFRSF1B(1), TP53(174) 5160329 216 157 146 6 52 37 22 20 82 3 <1.00e-15 <1.00e-15 <6.31e-14 9 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(22), ATR(5), CHEK1(1), CHEK2(3), TP53(174) 4342671 205 156 135 4 50 37 22 22 71 3 <1.00e-15 <1.00e-15 <6.31e-14 10 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(5), DNAJC3(1), EIF2S1(1), NFKB1(2), TP53(174) 2784224 183 155 113 4 47 32 18 16 67 3 1.11e-15 1.22e-15 6.31e-14 11 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(1), BIRC3(2), BNIP3L(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CHUK(5), DFFA(1), DFFB(2), FADD(1), FASLG(1), HELLS(2), IKBKB(2), IRF1(1), IRF4(4), IRF5(1), IRF6(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MDM2(2), NFKB1(2), PLEKHG5(4), PRF1(4), RIPK1(2), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFSF10(1), TP53(174), TP73(3), TRAF1(2), TRAF2(1), TRAF3(1) 15804413 271 167 201 26 70 56 30 28 84 3 1.04e-11 1.33e-15 6.31e-14 12 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(22), ATR(5), CCNA1(3), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), E2F1(2), GSK3B(3), HDAC1(1), RB1(8), TFDP1(1), TGFB2(1), TGFB3(2), TP53(174) 8232799 254 163 183 12 53 51 26 25 96 3 <1.00e-15 1.33e-15 6.31e-14 13 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(4), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), CASP6(1), CASP7(1), CASP9(1), EIF2S1(1), PRKCA(1), PTK2(1), PXN(3), STAT1(3), TLN1(7), TP53(174) 7511408 226 159 156 13 59 47 24 20 73 3 5.35e-14 1.33e-15 6.31e-14 14 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), FADD(1), FASLG(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MCL1(1), MDM2(2), NFKB1(2), PARP1(2), PRF1(4), RIPK1(2), TNFRSF1B(1), TNFSF10(1), TP53(174), TRAF1(2), TRAF2(1) 10290800 231 163 161 18 59 43 25 22 79 3 4.96e-12 1.78e-15 7.82e-14 15 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(22), ATR(5), BRCA1(6), CCNB1(1), CDC25A(3), CDC25B(2), CDKN1A(2), CDKN2D(1), CHEK1(1), CHEK2(3), EP300(12), MDM2(2), MYT1(4), PRKDC(14), RPS6KA1(1), TP53(174), WEE1(1), YWHAQ(1) 11842579 255 164 185 17 54 60 27 27 84 3 1.46e-12 2.11e-15 8.45e-14 16 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MAX(1), SP1(1), SP3(2), TP53(174), WT1(4) 1904802 183 154 113 6 48 31 18 18 65 3 1.89e-15 2.22e-15 8.45e-14 17 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(22), BAX(2), CCND1(1), CCNE1(2), CDK2(1), CDKN1A(2), E2F1(2), MDM2(2), RB1(8), TIMP3(2), TP53(174) 5001239 221 161 151 9 51 42 23 21 81 3 4.66e-15 2.33e-15 8.45e-14 18 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(4), EGFR(5), IGF1R(4), POLR2A(3), PPP2CA(1), PRKCA(1), RB1(8), TEP1(2), TERF1(2), TERT(2), TNKS(2), TP53(174), XRCC5(4) 7711695 212 159 141 15 52 41 22 16 78 3 4.08e-12 2.55e-15 8.74e-14 19 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(7), AKT1(4), ATM(22), BAX(2), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(2), NQO1(1), TP53(174) 5717213 227 161 156 9 53 52 25 22 72 3 <1.00e-15 3.11e-15 9.92e-14 20 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(22), ATR(5), BAI1(6), BAX(2), BID(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), CHEK1(1), CHEK2(3), DDB2(1), EI24(1), GADD45B(2), GTSE1(2), IGF1(1), IGFBP3(2), MDM2(2), MDM4(1), PERP(2), PMAIP1(1), PPM1D(2), PTEN(7), RCHY1(3), RFWD2(1), RRM2B(1), SERPINB5(2), SESN2(3), SESN3(1), STEAP3(4), THBS1(2), TNFRSF10B(1), TP53(174), TP73(3), TSC2(7) 18030959 308 169 237 21 71 64 31 29 109 4 <1.00e-15 3.22e-15 9.92e-14 21 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(22), CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDKN1A(2), CDKN1C(1), CDKN2A(19), CDKN2C(1), CDKN2D(1), CREB3L1(2), CREB3L4(1), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), GBA2(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MNAT1(1), MYT1(4), NACA(7), POLA2(2), POLE(8), POLE2(1), PRIM1(4), RB1(8), RBL1(2), RPA1(3), TFDP1(1), TFDP2(4), TNXB(14), TP53(174), WEE1(1) 21250868 314 165 243 29 73 71 30 35 102 3 2.32e-13 1.61e-13 4.72e-12 22 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(22), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCNE1(2), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(3), CDC25A(3), CDC25B(2), CDC6(5), CDC7(1), CDH1(1), CDK2(1), CDKN1A(2), CDKN2A(19), CHEK1(1), CHEK2(3), DTX4(2), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), EP300(12), ESPL1(8), GSK3B(3), HDAC1(1), HDAC3(3), HDAC4(12), HDAC5(2), HDAC6(3), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MPEG1(2), MPL(2), PLK1(2), PRKDC(14), PTPRA(4), RB1(8), RBL1(2), SMAD4(14), TBC1D8(3), TFDP1(1), TP53(174), WEE1(1) 30563516 380 172 303 34 86 92 38 35 126 3 <1.00e-15 3.38e-06 9.47e-05 23 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(21), PIK3R1(5), PLCB1(3), PLCG1(5), PRKCA(1), VAV1(8) 3557761 47 38 39 3 6 21 5 5 10 0 0.00101 0.000132 0.00354 24 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(17), NRG2(2), NRG3(8), PRKCA(1), PSEN1(2) 2524886 33 29 33 2 6 10 7 2 8 0 0.00484 0.000412 0.0106 25 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BAX(2), BTK(1), CAD(11), CASP8(6), CD7(1), CSNK1A1(2), DAXX(3), DEDD(1), DEDD2(1), DFFA(1), EGFR(5), EPHB2(4), FADD(1), FAF1(3), FAIM2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MET(4), NFAT5(4), NFKB1(2), NFKB2(2), NR0B2(1), PTPN13(7), RALBP1(2), RIPK1(2), ROCK1(2), SMPD1(2), TP53(174), TPX2(3), TRAF2(1) 20190050 281 164 211 36 71 63 29 29 86 3 1.81e-08 0.000493 0.0122 26 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(1), AKT1(4), AKT2(1), AKT3(2), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CAPN1(1), CAPN2(1), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CSF2RB(6), DFFA(1), DFFB(2), ENDOG(1), FADD(1), FASLG(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL3(2), IL3RA(1), IRAK1(2), IRAK3(1), IRAK4(1), NFKB1(2), NFKB2(2), NTRK1(5), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), TP53(174), TRAF2(1) 23247581 332 170 254 37 78 84 35 36 96 3 2.07e-12 0.000659 0.0156 27 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), PAK1(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), RAC1(1), WASL(2) 3706822 36 33 28 2 3 14 4 8 7 0 0.00685 0.00108 0.0246 28 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(1), CUL1(4), E2F1(2), FBXW7(14), RB1(8), TFDP1(1) 2346981 32 26 30 3 2 6 3 4 17 0 0.0946 0.00122 0.0268 29 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(6), FMOD(2), KERA(2), LUM(3) 981573 14 14 14 0 2 6 2 3 1 0 0.0195 0.00162 0.0344 30 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(15), AXIN1(2), BTRC(3), CTNNB1(9), DLL1(1), FZD1(4), GSK3B(3), NOTCH1(20), PSEN1(2), WNT1(1) 5943593 63 50 62 6 10 10 12 7 21 3 0.0104 0.00432 0.0888 31 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), PRKCE(2) 2197196 32 27 32 3 7 8 11 2 4 0 0.0105 0.00518 0.103 32 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(1), FURIN(2), NOTCH1(20), PSEN1(2) 2782582 28 25 28 2 5 2 3 5 11 2 0.0664 0.00688 0.133 33 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(1), CCND1(1), CCNE1(2), CDK2(1), CDKN2A(19), E2F1(2), E2F2(2), PRB1(2) 2466158 33 30 32 5 6 7 3 3 14 0 0.0753 0.0113 0.211 34 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), CDKN2C(1), CDKN2D(1), E2F1(2), RB1(8), RBL1(2), TFDP1(1) 4420427 49 40 48 6 4 13 4 4 24 0 0.0287 0.0117 0.212 35 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(1), CD80(1), CD86(1), HLA-DRB1(1), ITK(7), LCK(1), PIK3CA(21), PIK3R1(5), PTPN11(2) 3487944 41 37 33 5 5 17 7 5 7 0 0.0302 0.0276 0.486 36 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), IFNG(1), IL2RA(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TGFBR3(3), TOB1(2), TOB2(1) 2842910 30 28 27 4 4 11 3 6 6 0 0.129 0.0303 0.519 37 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), HRAS(1), KLK2(1), NTRK1(5), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), SOS1(3) 4293193 46 38 38 5 8 19 5 7 7 0 0.00940 0.0635 1.000 38 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GPHN(3), UBQLN1(1) 3356212 38 31 38 4 10 9 11 3 5 0 0.00940 0.0681 1.000 39 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), JUN(1), KEAP1(6), MAPK1(1), MAPK14(1), MAPK8(1), NFE2L2(18), PRKCA(1) 2590982 30 27 26 5 5 8 7 7 3 0 0.142 0.0685 1.000 40 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(4), INPPL1(2), PDK2(1), PIK3CA(21), PIK3R1(5), PPP2CA(1), PTEN(7) 5494188 55 46 47 6 4 21 9 6 14 1 0.00721 0.0707 1.000 41 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(11), GLS(2), GLUD1(1) 2139811 18 16 18 1 2 8 5 2 1 0 0.0318 0.0888 1.000 42 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(4), AKT2(1), AKT3(2), CDKN1A(2), ELK1(2), HRAS(1), MAP2K1(2), MAP2K2(3), NGFR(2), NTRK1(5), PIK3CA(21), PIK3CD(5), SOS1(3) 4628732 53 44 45 7 13 22 5 9 4 0 0.00423 0.0941 1.000 43 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), MKNK1(1), PDK2(1), PIK3CA(21), PIK3R1(5), PPP2CA(1), PTEN(7), TSC1(10), TSC2(7) 7692411 72 60 64 8 5 26 11 8 21 1 0.00249 0.0994 1.000 44 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), INSR(9), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3CA(21), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3) 6976484 66 53 58 6 12 24 10 8 12 0 0.000613 0.109 1.000 45 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADS(2), ACAT1(3), ECHS1(1), HADHA(2) 1517471 13 12 13 0 2 6 1 0 4 0 0.0680 0.116 1.000 46 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4), SNAP25(1), STX1A(2) 881127 9 8 8 0 6 1 1 1 0 0 0.0557 0.117 1.000 47 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(5), IFNG(1), IL12B(1) 817967 7 7 7 1 0 4 2 0 1 0 0.356 0.125 1.000 48 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(4), CALM3(1), GNAS(16), GNGT1(1), NFKB1(2), NOS3(5), NR3C1(1), PIK3CA(21), PIK3R1(5), SYT1(3) 4995573 60 50 52 9 14 22 7 5 12 0 0.0210 0.126 1.000 49 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(4), AOC3(5), CES1(5) 1669838 14 13 14 2 6 2 1 2 3 0 0.125 0.159 1.000 50 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(15), AXIN1(2), CREBBP(13), CTNNB1(9), EP300(12), FZD1(4), GSK3B(3), HDAC1(1), LDB1(1), PITX2(1), TRRAP(15), WNT1(1) 8831400 77 57 76 8 12 22 13 6 23 1 0.00167 0.176 1.000 51 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(4), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1) 2127906 19 19 19 2 5 7 4 2 1 0 0.0616 0.182 1.000 52 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(2), ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), ATM(22), ATR(5), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDC14A(2), CDC14B(1), CDC20(3), CDC23(1), CDC25A(3), CDC25B(2), CDC26(1), CDC27(7), CDC6(5), CDC7(1), CDK2(1), CDK6(2), CDKN1A(2), CDKN1C(1), CDKN2A(19), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(4), DBF4(3), E2F1(2), E2F2(2), E2F3(1), EP300(12), ESPL1(8), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), PKMYT1(2), PLK1(2), PRKDC(14), RB1(8), RBL1(2), RBL2(4), SMAD2(2), SMAD3(3), SMAD4(14), SMC1B(4), TFDP1(1), TGFB2(1), TGFB3(2), TP53(174), WEE1(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 37645484 423 172 351 42 78 112 43 44 142 4 1.47e-14 0.215 1.000 53 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(3), ESR1(6), GREB1(9), HSPB2(1), MTA1(3), MTA3(2), PDZK1(1), TUBA8(5) 3143384 30 26 30 3 8 8 5 5 4 0 0.00955 0.226 1.000 54 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(3) 1046227 7 7 7 0 2 1 2 0 2 0 0.125 0.238 1.000 55 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP54(5), SRP68(2), SRP72(2), SRPR(2) 2062185 13 13 13 1 1 4 3 3 2 0 0.205 0.245 1.000 56 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(2), CDK2(1), CUL1(4), E2F1(2), RB1(8), TFDP1(1) 2420467 21 20 21 4 1 5 2 2 11 0 0.404 0.246 1.000 57 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(1), CUL1(4), E2F1(2), NEDD8(2), RB1(8), TFDP1(1), UBE2M(1) 2384711 21 19 21 4 0 6 2 2 11 0 0.428 0.252 1.000 58 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(12), LPL(2), NCOA1(7), NCOA2(6), PPARG(2) 4973922 42 34 42 4 7 15 3 3 14 0 0.0122 0.263 1.000 59 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(22), CDC25A(3), CDC25B(2), CHEK1(1), MYT1(4), WEE1(1) 3766467 33 28 33 4 5 15 4 3 6 0 0.0353 0.281 1.000 60 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(8) 1025905 8 7 8 0 0 3 2 3 0 0 0.137 0.283 1.000 61 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JUN(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(21), PIK3R1(5), PLCG1(5), RAF1(2), SOS1(3) 5263606 48 40 40 7 8 20 6 7 7 0 0.0303 0.284 1.000 62 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(6), CFL1(1), CFLAR(2) 1010390 9 7 9 1 0 4 1 2 2 0 0.372 0.287 1.000 63 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(8), BCAR1(6), CSK(2), CTNNA1(7), CTNNA2(8), CTNNB1(9), PTK2(1), PXN(3), VCL(8) 5416110 53 46 51 7 17 16 6 6 8 0 0.00242 0.298 1.000 64 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), JAK2(2), JAK3(6), PIAS1(7), PIAS3(1), PTPRU(7), REG1A(1), SOAT1(1) 3863611 28 25 24 2 13 3 4 3 5 0 0.00762 0.300 1.000 65 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), HGD(2) 616902 4 4 4 0 1 1 0 0 2 0 0.469 0.300 1.000 66 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(8), CASP1(5), CASP8(6), CASP9(1), JUN(1), PRF1(4) 3494274 28 24 28 4 3 12 8 1 4 0 0.121 0.317 1.000 67 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(4) 557991 4 4 4 0 0 2 1 1 0 0 0.340 0.322 1.000 68 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(2) 475782 4 4 4 1 0 2 1 1 0 0 0.616 0.326 1.000 69 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS2(2), CPO(4), FECH(1), GATA1(1), HBA2(1), HBB(2), HMBS(1), UROD(1), UROS(1) 2228973 15 15 15 2 3 6 4 0 2 0 0.133 0.355 1.000 70 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(4), BCAR1(6), ILK(2), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(21), PIK3R1(5), PTEN(7), PTK2(1), SOS1(3) 5351483 52 46 44 9 5 20 7 9 10 1 0.0912 0.357 1.000 71 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(13), EP300(12), FYN(1), IL2RG(3), IL7R(3), JAK1(3), JAK3(6), LCK(1), PIK3CA(21), PIK3R1(5), PTK2B(4), STAT5A(3), STAT5B(2) 7654155 77 62 69 10 11 27 8 10 21 0 0.00640 0.366 1.000 72 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(2), CASP1(5), CASP7(1), CASP8(6), GAPDH(2), INSR(9), ITCH(3), MAGI1(4), MAGI2(8), RERE(7), WWP1(6), WWP2(3) 6362409 60 47 60 6 12 18 9 10 11 0 0.00241 0.383 1.000 73 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(2), ALDOC(4) 1053617 8 8 8 2 2 3 2 1 0 0 0.501 0.394 1.000 74 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), PPOX(4), UROD(1), UROS(1) 2036423 12 12 12 0 3 3 1 1 4 0 0.0382 0.408 1.000 75 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), TGDS(2), UGDH(3), UXS1(1) 1102634 7 7 7 1 1 2 1 1 2 0 0.524 0.409 1.000 76 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IGF1(1), IGF1R(4), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3CA(21), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3) 6814758 62 47 54 9 10 23 10 7 12 0 0.0224 0.425 1.000 77 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), IL2RG(3), IL4R(3), IRS1(6), JAK1(3), JAK3(6), STAT6(3) 4092468 28 24 28 2 5 4 6 7 6 0 0.0309 0.442 1.000 78 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(14), GNA12(1), PRKAG1(1), PRKAR2B(3) 2698874 19 17 19 2 1 11 1 4 2 0 0.113 0.449 1.000 79 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 2130519 18 17 18 3 7 4 2 1 4 0 0.168 0.483 1.000 80 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 2130519 18 17 18 3 7 4 2 1 4 0 0.168 0.483 1.000 81 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 1349243 8 8 8 1 3 5 0 0 0 0 0.208 0.484 1.000 82 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 195128 1 1 1 0 1 0 0 0 0 0 0.721 0.490 1.000 83 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), COPS5(3), EP300(12), HIF1A(5), JUN(1), NOS3(5), P4HB(2) 4694880 29 28 29 2 2 16 3 2 6 0 0.0256 0.498 1.000 84 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(1), RB1(8), SP1(1), SP3(2) 1793973 15 13 15 6 0 4 0 2 9 0 0.962 0.502 1.000 85 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 445864 2 2 2 0 1 0 1 0 0 0 0.517 0.507 1.000 86 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(2), HLA-DRB1(1), IL3(2) 836730 6 5 6 1 2 1 0 0 3 0 0.482 0.517 1.000 87 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(3), PTPRU(7), REG1A(1), STAT1(3), STAT2(4), TYK2(3) 3478016 23 20 23 1 8 6 2 3 4 0 0.00470 0.524 1.000 88 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CSF1(1), IL6(1), LDLR(3), LPL(2) 1449176 10 9 10 1 1 3 1 0 5 0 0.205 0.524 1.000 89 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(16), GNGT1(1), PRKACA(3) 1804529 25 25 25 5 10 6 2 2 5 0 0.271 0.525 1.000 90 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(1), BDH1(1), BDH2(4), HMGCS2(2), OXCT2(1) 1974087 12 11 12 1 0 7 1 1 3 0 0.228 0.536 1.000 91 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(8), GNAS(16), PRKAR1B(2), PRKAR2B(3), SLC9A3R1(3) 3580931 38 35 38 7 11 11 2 6 8 0 0.198 0.553 1.000 92 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), HLA-DRB1(1), IL1B(3), IL5RA(4), IL6(1) 1455578 11 10 11 2 2 5 0 0 4 0 0.313 0.555 1.000 93 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(7), ABCB11(6), ABCB4(4), ABCC1(3), ABCC3(2), GSTP1(1) 4014069 23 22 21 0 2 9 6 1 5 0 0.00117 0.563 1.000 94 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(4), FUT1(1), FUT9(4) 1675929 9 9 9 0 5 3 0 1 0 0 0.0392 0.569 1.000 95 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), PTPRU(7), REG1A(1), STAT1(3) 3156241 18 17 18 1 6 5 1 1 5 0 0.0211 0.577 1.000 96 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PDXP(3), PNPO(2), PSAT1(3) 1312884 12 12 12 4 2 6 2 1 1 0 0.600 0.603 1.000 97 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), TGDS(2), UGDH(3), UXS1(1) 1384425 7 7 7 1 1 2 1 1 2 0 0.527 0.618 1.000 98 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), CHRNB1(6), CHRNG(3), MUSK(2), PIK3CA(21), PIK3R1(5), PTK2(1), PTK2B(4), RAPSN(2), TERT(2) 4605445 50 38 42 9 11 18 4 5 12 0 0.0388 0.629 1.000 99 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(3), ACAT2(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 2325113 13 12 13 1 1 8 0 0 4 0 0.193 0.649 1.000 100 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(2), CDKN1A(2), CHEK1(1), NEK1(3), WEE1(1) 2118074 12 12 12 2 3 6 0 1 2 0 0.330 0.649 1.000 101 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(3) 812690 4 4 4 1 0 2 1 0 1 0 0.683 0.651 1.000 102 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), IDH2(4), MDH1(2), OGDH(2), SDHA(4) 2609673 13 13 13 0 4 5 1 1 2 0 0.0127 0.651 1.000 103 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(12), ESR1(6), MAPK1(1), PELP1(3) 3966827 35 30 35 6 7 11 5 2 10 0 0.110 0.653 1.000 104 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(2), SHMT1(2), SHMT2(2) 1595795 8 8 8 1 2 2 1 1 2 0 0.303 0.654 1.000 105 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 310721 1 1 1 0 0 1 0 0 0 0 0.743 0.660 1.000 106 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(4), F2R(4), F5(4), F7(1), FGA(4), FGB(3), FGG(1), PROC(1), PROS1(5), TFPI(2) 4498404 31 27 30 4 5 9 6 4 7 0 0.0977 0.661 1.000 107 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(2), FSHR(6), GNAS(16), XPO1(4) 2613014 33 29 32 7 10 9 3 5 6 0 0.387 0.662 1.000 108 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF1(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), ELAVL1(3), FLT1(7), FLT4(5), HIF1A(5), HRAS(1), KDR(5), NOS3(5), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PXN(3) 9452084 79 57 70 9 13 36 6 12 12 0 0.000655 0.663 1.000 109 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 3296820 23 21 23 3 8 8 2 1 4 0 0.0564 0.678 1.000 110 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(2), ACO2(1), ACSS1(2), ACSS2(8), IDH1(1), IDH2(4), MDH1(2), MDH2(2) 3642127 24 19 24 1 3 16 0 3 2 0 0.00435 0.682 1.000 111 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 412019 1 1 1 0 0 0 0 0 1 0 0.803 0.684 1.000 112 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(1), IDH1(1), IDH2(4), MDH1(2), MDH2(2) 2453598 12 12 12 0 3 7 0 1 1 0 0.0289 0.684 1.000 113 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(4), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), E2F1(2), HRAS(1), MAPK1(1), NFKB1(2), PAK1(2), PIK3CA(21), PIK3R1(5), RAC1(1), RAF1(2), RB1(8), TFDP1(1) 5604184 58 47 50 10 3 21 6 9 19 0 0.0631 0.691 1.000 114 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), ECHS1(1), HADH(1), HADHA(2), HSD17B4(4), PPT1(1), PPT2(1) 2357126 14 13 14 2 2 7 0 1 4 0 0.312 0.691 1.000 115 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), PC(1), PCK1(2), SDHA(4), SUCLG1(2), SUCLG2(1) 5674098 31 28 30 1 5 15 3 1 7 0 0.00129 0.695 1.000 116 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(3), SNCAIP(4), UBE2F(1), UBE2G2(1), UBE2L6(1) 1699678 12 11 12 3 3 4 1 1 3 0 0.433 0.700 1.000 117 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(1), MUT(3) 1333526 7 7 7 0 1 3 1 1 1 0 0.132 0.713 1.000 118 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(2), IDI1(1), SQLE(1) 921844 6 6 6 2 0 5 1 0 0 0 0.647 0.716 1.000 119 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(1) 942886 4 4 4 0 0 2 0 0 2 0 0.617 0.724 1.000 120 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(2), APOBEC2(2), APOBEC3F(1), APOBEC3G(2), APOBEC4(2) 2013603 14 13 14 3 4 8 1 1 0 0 0.293 0.729 1.000 121 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(6), CSF1R(9), EGF(4), EGFR(5), MET(4), PDGFRA(4), PRKCA(1), SH3GLB1(2), SH3GLB2(2), SH3KBP1(5) 5320627 42 35 42 6 6 20 2 6 8 0 0.0442 0.736 1.000 122 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), PANK1(3), PANK2(4), PANK3(4), PANK4(4) 3853861 34 33 34 8 4 17 3 4 6 0 0.255 0.741 1.000 123 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(4), AKT2(1), AKT3(2), BTK(1), CDKN2A(19), DAPP1(1), GSK3A(2), GSK3B(3), IARS(4), INPP5D(4), PIK3CA(21), PPP1R13B(4), PTEN(7), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 9823471 87 67 78 12 11 33 11 10 21 1 0.00427 0.744 1.000 124 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(15), CDH1(1), CREBBP(13), EP300(12), MAP2K1(2), MAP3K7(3), SKIL(2), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15) 6789133 68 55 63 12 10 20 9 6 23 0 0.147 0.755 1.000 125 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADS(2), ACADVL(2), ACSL1(2), ACSL3(3), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(1), HADHA(2), SCP2(1) 4590338 22 20 22 0 4 10 2 1 5 0 0.00218 0.761 1.000 126 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), CASP9(1), CHUK(5), GH1(1), GHR(2), NFKB1(2), PIK3CA(21), PIK3R1(5), PPP2CA(1) 3883701 42 35 34 9 3 18 8 4 9 0 0.257 0.776 1.000 127 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PDGFA(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3) 9614440 83 60 75 10 15 31 12 9 16 0 0.00154 0.782 1.000 128 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), SHMT1(2), SHMT2(2) 1212733 5 5 5 1 1 2 1 0 1 0 0.521 0.784 1.000 129 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(2), ACO2(1), CLYBL(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), OGDHL(6), PC(1), PCK1(2), PCK2(2), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1) 8196688 46 37 45 1 9 20 5 3 9 0 1.41e-05 0.787 1.000 130 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), SDS(1) 2178288 11 10 11 1 1 8 0 0 2 0 0.197 0.798 1.000 131 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), GSK3B(3), PPP1CA(1) 3132538 14 13 14 1 2 6 2 0 3 1 0.0728 0.808 1.000 132 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(5), PRKCA(1), PTK2B(4) 1797444 10 10 10 2 2 5 0 0 3 0 0.342 0.814 1.000 133 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(2), IDI1(1), IDI2(1), SQLE(1) 1216703 7 7 7 2 1 5 1 0 0 0 0.555 0.815 1.000 134 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(2), GAD1(3), GAD2(2) 1618379 7 7 7 1 1 4 0 0 2 0 0.408 0.815 1.000 135 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD1(1), GLUD2(4) 1225159 7 6 7 2 1 4 1 0 1 0 0.555 0.826 1.000 136 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(4), ACOX3(1), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3) 2941902 17 16 17 2 6 7 0 0 4 0 0.0619 0.829 1.000 137 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2) 3490731 19 17 19 2 3 9 5 1 1 0 0.0607 0.832 1.000 138 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(3), MST1R(7) 1780726 11 8 11 1 1 5 0 2 3 0 0.182 0.833 1.000 139 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3) 2906993 15 14 15 2 2 2 5 4 2 0 0.216 0.834 1.000 140 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3) 2906993 15 14 15 2 2 2 5 4 2 0 0.216 0.834 1.000 141 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(2), B3GNT5(1), FUT1(1), FUT3(2), ST3GAL3(1), ST3GAL4(1) 1943274 8 8 8 0 2 3 0 3 0 0 0.0962 0.835 1.000 142 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(3), STAT1(3), STAT2(4), TYK2(3) 3035561 15 14 15 1 4 5 2 3 1 0 0.0615 0.846 1.000 143 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(1), AFMID(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2) 3668877 20 18 20 2 4 9 5 1 1 0 0.0447 0.859 1.000 144 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(15), AXIN1(2), CCND1(1), CD14(1), CTNNB1(9), FZD1(4), GJA1(1), GNAI1(1), GSK3B(3), IRAK1(2), NFKB1(2), PIK3CA(21), PIK3R1(5), PPP2CA(1), TLR4(6), TOLLIP(1), WNT1(1) 8234266 80 60 71 12 7 25 19 7 21 1 0.0143 0.865 1.000 145 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), ST3GAL5(1) 1481459 7 7 7 1 1 2 2 2 0 0 0.367 0.865 1.000 146 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(3), CDC25B(2), CSK(2), PRKCA(1), PTPRA(4) 2558073 13 13 13 2 3 8 0 0 2 0 0.138 0.876 1.000 147 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), DLD(4), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), PC(1), PDHA2(5), PDHX(1), PDK2(1), PDK3(2), PDK4(1), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1) 7832029 41 39 40 4 6 16 7 1 11 0 0.00918 0.879 1.000 148 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(2), FARSB(1), PAH(4), TAT(2), YARS(1), YARS2(2) 2404317 12 12 12 3 1 3 3 1 4 0 0.484 0.879 1.000 149 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(2), TYR(3) 1270875 7 7 7 2 3 2 1 0 1 0 0.527 0.883 1.000 150 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(14), MAP2(11), PPP1CA(1), PPP2CA(1), PRKAG1(1), PRKAR2B(3), PRKCE(2) 4782075 33 28 33 5 4 10 5 8 6 0 0.136 0.889 1.000 151 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 718746 2 2 2 0 0 1 0 0 1 0 0.500 0.889 1.000 152 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(4), NTAN1(2), SIRT1(5), SIRT5(1), SIRT7(1) 3274960 21 18 21 4 5 11 2 0 3 0 0.236 0.902 1.000 153 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD80(1), HLA-DRB1(1), IL10(2) 1079094 5 5 5 2 1 2 1 0 1 0 0.761 0.904 1.000 154 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(1), BAX(2), BCL10(1), BCL2L1(1), BCL2L11(3), BID(1), CASP9(1), CES1(5) 3071027 18 17 18 4 6 5 3 0 4 0 0.298 0.906 1.000 155 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(6), MAPK1(1), MAPK14(1), MKNK1(1), PABPC1(2), PDK2(1), PIK3CA(21), PIK3R1(5), PRKCA(1), PTEN(7) 7749922 67 53 59 11 5 24 10 6 21 1 0.0541 0.910 1.000 156 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(4), HLA-A(1), ITGB1(1), KLRC3(1), KLRC4(1), KLRD1(2), MAP2K1(2), PAK1(2), PIK3CA(21), PIK3R1(5), PTK2B(4), RAC1(1), SYK(2), VAV1(8) 5223603 55 41 47 10 6 20 4 10 15 0 0.101 0.913 1.000 157 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), THTPA(1) 1739953 9 6 8 2 0 4 1 0 4 0 0.556 0.917 1.000 158 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRB1(1) 640755 2 2 2 2 0 1 0 0 1 0 0.970 0.923 1.000 159 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(5), GNAS(16), GNGT1(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1) 2672013 28 27 28 7 12 6 2 1 6 1 0.334 0.923 1.000 160 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2), MASP1(4), MBL2(4) 5944043 42 36 42 7 7 18 2 7 8 0 0.0684 0.924 1.000 161 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), PGM1(1), TGDS(2) 2859277 11 11 11 1 3 5 0 0 3 0 0.132 0.924 1.000 162 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(4), BCL2L1(1), CASP9(1), CHUK(5), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(2), NFKB1(2), PIK3CA(21), PIK3R1(5), RAC1(1), RAF1(2), RALA(1), RALBP1(2), RHOA(3) 5453038 54 39 46 10 7 22 9 6 10 0 0.0611 0.925 1.000 163 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(3) 2511337 16 14 16 4 3 9 2 0 2 0 0.339 0.928 1.000 164 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2) 4876386 34 30 34 6 6 14 2 6 6 0 0.147 0.933 1.000 165 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2) 3485087 28 25 28 6 4 12 2 5 5 0 0.327 0.935 1.000 166 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(3), JAK2(2), JAK3(6), PIAS3(1), PTPRU(7), REG1A(1), STAT3(2) 4245760 24 23 24 4 7 5 3 3 6 0 0.0943 0.937 1.000 167 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C8B(3), C9(2), MASP1(4) 5775304 41 34 41 7 8 15 3 7 8 0 0.0829 0.941 1.000 168 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(5), AKT1(4), BAX(2), BCL2L1(1), CSF2RB(6), IGF1(1), IGF1R(4), IL3(2), IL3RA(1), KIT(7), KITLG(2), PIK3CA(21), PIK3R1(5), PRKAR1B(2), PRKAR2B(3) 6035083 66 51 58 14 9 23 12 9 13 0 0.0932 0.942 1.000 169 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), GNAS(16), PLCE1(10), PRKAR1B(2), PRKAR2B(3), RAP2B(1) 4033559 38 34 38 9 12 12 3 4 7 0 0.284 0.942 1.000 170 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), ST3GAL6(1) 4317984 26 23 26 4 9 9 4 3 1 0 0.0578 0.943 1.000 171 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), STAT1(3) 2255006 10 9 10 2 2 4 1 1 2 0 0.413 0.944 1.000 172 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(6), ABCG2(6), BCHE(9), CES1(5), CES2(1), CYP3A5(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2) 6256205 42 35 42 7 9 13 5 3 12 0 0.0458 0.944 1.000 173 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), L2HGDH(3), PDHA2(5), SDS(1) 7031960 48 39 48 6 11 19 4 5 9 0 0.0100 0.944 1.000 174 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(4), CREB5(2), MAPK1(1), RAF1(2), SNX13(6), TERF2IP(1) 3193499 16 15 16 3 1 8 1 5 1 0 0.324 0.945 1.000 175 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(2), DHRSX(1), HSD3B7(2), PON1(1), PON2(2), PON3(4), RDH13(1) 2430675 14 12 14 4 2 1 4 3 4 0 0.612 0.946 1.000 176 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(1), MAP3K1(8), MYLK(6), PAK1(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(2), TRIO(4), VAV1(8), WASF1(3) 9558555 74 60 65 12 10 25 12 9 18 0 0.0219 0.950 1.000 177 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), FLT3(9), IGF1(1), IL3(2), IL6(1), KITLG(2), TGFB2(1), TGFB3(2) 2330556 20 17 20 5 2 7 3 1 7 0 0.357 0.951 1.000 178 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), ISYNA1(1), PGM1(1), TGDS(2) 3250139 12 12 12 1 3 5 0 1 3 0 0.106 0.952 1.000 179 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(1), PPARG(2), RETN(1) 1561641 7 7 7 2 3 0 0 0 4 0 0.657 0.954 1.000 180 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(1), GLS(2), GLUD1(1), OAT(3) 1616974 11 11 11 4 3 3 3 0 2 0 0.598 0.954 1.000 181 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(4), XDH(9) 2230932 14 14 14 4 1 5 5 1 2 0 0.489 0.958 1.000 182 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT3(2), FUT5(1), FUT6(2), ST3GAL3(1) 1399674 7 7 7 2 3 3 0 1 0 0 0.442 0.958 1.000 183 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3E(1), CD58(1), CSF3(2), IL3(2), IL6(1), KITLG(2) 1727349 12 10 12 4 2 5 1 1 3 0 0.625 0.961 1.000 184 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(2), CASP8(6), FADD(1), RIPK1(2), TNFRSF1B(1), TRAF2(1) 2290847 13 11 13 3 3 3 2 2 3 0 0.399 0.961 1.000 185 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(13), DFFA(1), DFFB(2), GZMA(1), HMGB2(1), PRF1(4), SET(3) 2890230 26 24 26 7 7 7 2 2 8 0 0.457 0.965 1.000 186 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(5), CREBBP(13), EP300(12), IKBKB(2), IL1B(3), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NR3C1(1), TGFBR1(2), TGFBR2(15), TLR2(5) 7999458 65 51 61 11 11 18 10 5 21 0 0.0953 0.966 1.000 187 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25A(3), CDC25B(2), MNAT1(1), XPO1(4) 2377248 11 9 10 3 2 4 0 2 3 0 0.691 0.966 1.000 188 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), PAPSS2(3), SCLY(2), SEPHS1(3) 3449819 17 15 17 3 5 4 3 2 3 0 0.157 0.966 1.000 189 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(4), EGFR(5), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3) 10288864 86 59 78 12 13 37 11 9 16 0 0.00442 0.967 1.000 190 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM3(1), CDKN1A(2), GNAQ(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SP1(1), SP3(2), SYT1(3) 5487856 38 33 38 7 10 14 2 5 7 0 0.0906 0.968 1.000 191 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 606620 1 1 1 0 0 1 0 0 0 0 0.721 0.968 1.000 192 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(2), NDUFA1(1), SDHA(4), SDHD(2) 1773501 11 11 11 4 1 5 2 0 3 0 0.754 0.969 1.000 193 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB1A(1), RAB27A(2), RAB4A(1), RAB5A(1) 1164903 6 6 6 3 2 3 0 0 1 0 0.800 0.973 1.000 194 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(2), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 1896878 14 11 14 4 3 8 0 1 2 0 0.402 0.973 1.000 195 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FOS(1), FYN(1), JUN(1), MAPK14(1), THBS1(2) 1986112 8 8 8 2 1 3 2 0 2 0 0.649 0.973 1.000 196 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(1) 866172 3 3 3 2 1 2 0 0 0 0 0.820 0.973 1.000 197 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), LPO(3), MPO(3), PRDX6(3), TPO(8) 2329253 21 20 21 6 6 4 2 3 6 0 0.398 0.974 1.000 198 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(3), HDC(2), TH(3), TPH1(2) 1655011 11 9 11 3 4 5 0 2 0 0 0.371 0.974 1.000 199 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), HRH1(2), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3) 6897069 74 58 73 17 20 25 10 10 9 0 0.0119 0.975 1.000 200 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(4), MMP2(3), MMP9(3), RECK(4), TIMP3(2), TIMP4(2) 2133835 19 18 19 5 7 7 0 2 3 0 0.304 0.977 1.000 201 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(1), BMPR1B(4), BMPR2(3) 1666481 9 9 9 3 0 4 4 0 1 0 0.706 0.977 1.000 202 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2), NDUFA13(1) 1178758 4 4 4 2 1 2 1 0 0 0 0.766 0.977 1.000 203 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8) 3283440 27 26 27 7 7 7 4 3 6 0 0.282 0.978 1.000 204 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(3), RANBP2(6), RANGAP1(1) 2355983 10 7 10 2 0 6 3 0 1 0 0.572 0.979 1.000 205 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10(2), IL10RA(3), IL10RB(1), IL6(1), JAK1(3), STAT1(3), STAT3(2), STAT5A(3) 3357001 22 16 21 4 4 8 2 2 6 0 0.112 0.980 1.000 206 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), MIOX(2), UGDH(3) 2301132 16 14 16 4 6 6 0 1 3 0 0.405 0.981 1.000 207 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(5), AASS(3), KARS(2) 1892480 11 11 11 4 1 6 1 1 2 0 0.793 0.981 1.000 208 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), CKM(1), FBL(2), GPT(4), MAPK14(1), NCL(5) 2510653 14 13 14 4 6 2 0 1 5 0 0.543 0.983 1.000 209 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIK(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), ENDOG(1) 3742336 25 20 25 6 6 8 3 1 7 0 0.376 0.984 1.000 210 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(5), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), SDS(1) 7903442 52 45 52 9 16 19 5 3 9 0 0.0251 0.987 1.000 211 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(3), NR0B2(1), NR1H4(2) 1487957 7 7 7 3 1 3 1 0 2 0 0.726 0.987 1.000 212 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(4), FYN(1), LRP8(3), RELN(17) 3792313 26 24 24 6 5 13 2 3 3 0 0.309 0.987 1.000 213 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(4), HRAS(1), IGF1R(4), IRS1(6), MAP2K1(2), MAPK1(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOS1(3) 5182218 49 38 41 10 7 18 8 7 9 0 0.155 0.987 1.000 214 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MPL(2), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), THPO(2) 8233552 68 49 60 10 12 29 6 8 13 0 0.0151 0.987 1.000 215 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(3), AGT(1), AGTR2(2), KNG1(2), NOS3(5), REN(2) 2712517 15 14 15 4 1 8 2 0 4 0 0.375 0.988 1.000 216 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1), ITPKB(6) 1545526 8 7 8 7 1 4 0 0 3 0 0.966 0.988 1.000 217 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(4), GLI2(5), GLI3(9), GSK3B(3), PRKAR1B(2), PRKAR2B(3), SMO(4), SUFU(2) 4490658 36 29 36 9 5 12 5 4 10 0 0.333 0.990 1.000 218 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(1), F2(4), F2R(4), FGA(4), FGB(3), FGG(1), PLAT(1), PLG(3), SERPINB2(2) 3679760 24 20 23 5 4 7 3 1 9 0 0.404 0.990 1.000 219 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), AKT1(4), CAMK2A(3), CAMK2B(2), GNAS(16), HRAS(1), MAPK1(1), MAPK14(1), PIK3CA(21), PIK3R1(5), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(4), SOS1(3) 8035746 74 57 66 13 18 26 7 11 12 0 0.0325 0.990 1.000 220 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM3(1), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PAK2(1), PIK3CA(21), PIK3R1(5), PLA2G4A(1), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8) 11666378 97 64 89 14 20 34 12 11 20 0 0.00220 0.991 1.000 221 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(11), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1) 2341377 21 20 21 9 5 8 2 0 6 0 0.712 0.991 1.000 222 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(3), HSD17B1(1), HSD17B4(4), HSD3B1(2), HSD3B2(3) 2189461 14 9 14 3 2 7 2 0 3 0 0.438 0.991 1.000 223 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), BIRC3(2), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), LMNA(2), LMNB1(1), LMNB2(5), PRF1(4) 5263175 37 31 37 7 8 13 5 2 9 0 0.140 0.992 1.000 224 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CDK2(1), CDKN2A(19), CREB5(2), ERBB4(17), F2RL2(1), GAB1(1), GSK3A(2), GSK3B(3), IFI27(2), IGF1(1), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), MET(4), NOLC1(4), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARD3(7), PARD6A(1), PIK3CA(21), PIK3CD(5), PPP1R13B(4), PREX1(5), PTEN(7), PTK2(1), PTPN1(5), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TSC1(10), TSC2(7), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 21060993 181 105 172 25 33 59 21 21 46 1 6.88e-06 0.992 1.000 225 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), CD3E(1), HLA-A(1), ICAM1(1), ITGAL(6), PRF1(4) 2368742 17 15 17 8 2 6 0 3 6 0 0.860 0.993 1.000 226 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD14(1), RPN1(3), RPN2(3), UBE3A(3) 3659562 22 18 22 5 3 9 2 4 4 0 0.311 0.993 1.000 227 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(4), AKT2(1), AKT3(2), GSK3A(2), GSK3B(3), IL4R(3), IRS1(6), IRS2(3), JAK1(3), JAK3(6), MAPK1(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PPP1R13B(4), RAF1(2), SOS1(3), SOS2(1), STAT6(3) 10039590 78 60 70 13 13 25 11 13 16 0 0.0202 0.994 1.000 228 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(4), AOC3(5), CES1(5), DDHD1(4), ESCO1(3), ESCO2(1), PLA1A(1), PPME1(1), PRDX6(3), SH3GLB1(2) 6815960 29 26 29 4 8 8 2 2 9 0 0.0473 0.994 1.000 229 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), HRAS(1), MAPK1(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), NTRK1(5), PIK3CA(21), PIK3R1(5), PLCG1(5), RPS6KA1(1) 5390256 50 42 42 10 10 20 5 6 9 0 0.0767 0.994 1.000 230 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRB1(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL2RA(1), IL4R(3) 3466155 16 14 16 4 0 6 2 5 3 0 0.622 0.994 1.000 231 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(5), IFNG(1), IKBKB(2), JUN(1), MAP3K1(8), MAP3K5(8), MAP4K5(6), MAPK14(1), MAPK8(1), NFKB1(2), TNFRSF9(1), TNFSF9(2), TRAF2(1) 5427842 39 28 39 9 7 11 6 5 10 0 0.460 0.995 1.000 232 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), P2RY1(2), P2RY6(2) 1518997 14 13 14 5 3 7 1 2 1 0 0.414 0.995 1.000 233 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASS(3), KARS(2) 1296491 6 6 6 3 1 2 1 1 1 0 0.860 0.995 1.000 234 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), FDXR(2), SHMT1(2) 4409891 19 18 19 4 5 4 2 5 3 0 0.346 0.995 1.000 235 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), SQLE(1) 3675562 17 17 17 4 2 10 1 0 4 0 0.402 0.996 1.000 236 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(4), EGFR(5), HGS(1), RAB5A(1), TF(4), TFRC(2) 3504948 19 17 19 5 2 11 4 0 2 0 0.376 0.996 1.000 237 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), CAMKK2(4), SYT1(3) 3213717 16 15 16 4 7 3 3 0 3 0 0.330 0.996 1.000 238 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(22), BMPR1B(4), DMC1(2), EGR1(2), ESR2(1), FSHR(6), INHA(1), LHCGR(6), MLH1(2), MSH5(1), NCOR1(4), NRIP1(3), PGR(5), PRLR(3), PTGER2(1), SMPD1(2), VDR(2), ZP2(1) 9437626 68 57 68 11 9 25 8 10 15 1 0.0153 0.996 1.000 239 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), FUT8(2), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), RPN1(3), RPN2(3) 5383550 34 32 34 8 7 13 5 4 5 0 0.192 0.996 1.000 240 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(5), CREBBP(13), EP300(12), FADD(1), HDAC3(3), IKBKB(2), NFKB1(2), RIPK1(2), TNFRSF1B(1), TRAF6(1) 6102439 42 35 42 9 6 12 6 3 15 0 0.282 0.996 1.000 241 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(3), PAH(4), TAT(2), YARS(1) 2256562 11 11 11 4 1 3 3 2 2 0 0.672 0.997 1.000 242 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), EIF4EBP1(1), IFNG(1), IL1R1(1), NR4A3(2), WDR1(1) 2948940 8 8 8 2 2 2 0 0 4 0 0.356 0.997 1.000 243 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5) 1874055 5 5 5 2 2 2 0 1 0 0 0.709 0.997 1.000 244 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(2), ME1(1), PC(1), SLC25A1(1) 2561793 7 7 7 1 2 3 1 1 0 0 0.296 0.997 1.000 245 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3) 1828015 15 13 15 5 6 4 1 1 3 0 0.567 0.997 1.000 246 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3) 1828015 15 13 15 5 6 4 1 1 3 0 0.567 0.997 1.000 247 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(1), AKT3(2), IARS(4), IL13RA1(1), IL2RG(3), IL4R(3), INPP5D(4), JAK1(3), JAK2(2), JAK3(6), NR0B2(1), PIK3CA(21), PPP1R13B(4), SERPINA4(4), SOS1(3), SOS2(1), STAT6(3), TYK2(3) 10222713 73 58 65 11 13 24 10 17 9 0 0.0112 0.997 1.000 248 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(4), EPHB2(4), F2(4), F2RL1(1), F2RL2(1), F2RL3(2), JUN(1), MAP2K5(2), MAPK1(1), MAPK7(1), MAPK8(1), MYEF2(2), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RAF1(2), TEC(1), VAV1(8) 7570878 45 40 44 9 10 15 5 3 12 0 0.142 0.997 1.000 249 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1) 2705823 11 11 11 3 4 4 1 2 0 0 0.438 0.997 1.000 250 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), MBTPS1(4), MBTPS2(5), SCAP(4), SREBF1(3), SREBF2(2) 3246479 21 18 20 6 4 9 1 3 4 0 0.389 0.997 1.000 251 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TPO(8), TYR(3) 2686387 25 24 25 8 7 6 4 3 5 0 0.468 0.997 1.000 252 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(1), CSF3(2), IL3(2), IL6(1) 1714946 6 5 6 7 2 1 0 0 3 0 0.995 0.998 1.000 253 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), HSD3B7(2), RDH13(1) 1333296 5 5 5 3 1 2 0 1 1 0 0.801 0.998 1.000 254 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM3(1), CD3E(1), ELK1(2), FOS(1), FYN(1), HRAS(1), JUN(1), LCK(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PIK3CA(21), PIK3R1(5), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PTPN7(1), RAC1(1), RAF1(2), RASA1(9), SOS1(3), SYT1(3), VAV1(8), ZAP70(3) 13051025 109 72 101 16 23 40 12 11 23 0 0.00118 0.998 1.000 255 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1) 4789116 19 19 19 4 5 7 3 3 1 0 0.253 0.998 1.000 256 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ADSL(3), AGXT(2), ASL(3), ASNS(5), ASPA(2), CAD(11), CRAT(2), DDO(1), GAD1(3), GAD2(2), GPT(4), GPT2(1), PC(1) 7233311 43 36 43 6 14 12 6 5 6 0 0.0292 0.998 1.000 257 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(4), CYP1A2(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), RDH13(1) 6790113 35 28 35 6 11 14 2 4 4 0 0.0570 0.998 1.000 258 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 259 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 260 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 261 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM3(1), CAPN2(1), CAPNS1(3), CAPNS2(1), EP300(12), HDAC1(1), MEF2D(3), NFATC1(4), NFATC2(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SYT1(3) 6558104 50 44 49 11 13 18 4 2 13 0 0.0837 0.999 1.000 262 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), LPO(3), MPO(3), MTHFR(2), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8) 3180236 25 24 25 8 7 6 3 2 7 0 0.479 0.999 1.000 263 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(3), CP(3), CPOX(1), EPRS(3), FECH(1), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UROD(1), UROS(1) 7468091 37 34 37 6 9 12 5 5 6 0 0.0578 0.999 1.000 264 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(2), PTGS1(2) 1463913 5 4 5 3 1 3 0 0 1 0 0.789 0.999 1.000 265 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(2), COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), ILVBL(1), PANK1(3), PANK2(4), PANK3(4), PANK4(4), PPCDC(1), VNN1(4) 4829209 42 40 42 11 5 23 4 4 6 0 0.266 0.999 1.000 266 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3) 1544872 9 9 9 7 4 3 0 1 1 0 0.948 0.999 1.000 267 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(1), PTK2B(4), SOS1(3) 2381055 8 8 8 3 1 3 0 2 2 0 0.787 0.999 1.000 268 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1) 1971862 8 6 8 3 4 2 0 0 2 0 0.624 0.999 1.000 269 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EARS2(1), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), GMPS(3), GPT(4), GPT2(1), GSR(3), NADSYN1(2), NAGK(2), QARS(3) 10865694 70 54 70 10 14 25 9 10 12 0 0.00836 0.999 1.000 270 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), HEMK1(1), LCMT1(1), METTL2B(1), PCYT1A(2), PCYT1B(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1) 3854921 17 15 17 4 4 8 1 1 3 0 0.331 0.999 1.000 271 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(1), ALDH18A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), ASS1(1), CPS1(11), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(1), OTC(1), SAT1(1), SRM(3) 8066661 59 47 59 11 14 16 6 7 16 0 0.0620 0.999 1.000 272 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(6), ADSL(3), ADSSL1(1), AGXT(2), ASL(3), ASNS(5), ASPA(2), ASRGL1(2), ASS1(1), CAD(11), CRAT(2), DARS2(2), DDO(1), DLAT(1), DLD(4), GAD1(3), GAD2(2), GPT(4), GPT2(1), NARS2(1), PC(1), PDHA2(5) 10502296 66 52 66 9 18 21 11 5 11 0 0.00647 0.999 1.000 273 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PGK1(1), PKLR(3), RPE(1), RPIA(1), TKT(1) 4869690 29 27 29 7 8 11 1 2 7 0 0.238 0.999 1.000 274 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(1), GSK3B(3), MAPT(1), PPP2CA(1) 2637756 17 15 17 5 3 8 3 0 3 0 0.380 0.999 1.000 275 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(1), GOSR1(1), GOSR2(1), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(3), STX17(2), STX18(1), STX19(2), STX2(1), STX5(1), STX6(2), VAMP4(2), VAMP5(1), VAMP8(1), VTI1A(3), YKT6(1) 4696263 29 28 29 7 7 9 5 4 4 0 0.345 0.999 1.000 276 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(3), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), GAMT(1), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(1), OTC(1) 4944513 35 29 35 9 6 11 6 3 9 0 0.321 0.999 1.000 277 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CRY1(1), CRY2(2), CSNK1E(1), PER1(5) 2313732 11 10 11 5 3 4 1 0 3 0 0.717 0.999 1.000 278 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(4), GH1(1), GHR(2), HRAS(1), IGF1(1), IGF1R(4), PIK3CA(21), PIK3R1(5) 3597942 39 33 31 10 4 16 8 4 7 0 0.359 0.999 1.000 279 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(15), AXIN1(2), BTRC(3), CCND1(1), CREBBP(13), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(9), FRAT1(1), FZD1(4), GSK3B(3), HDAC1(1), MAP3K7(3), NLK(4), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1) 8075869 69 49 67 14 13 17 12 4 22 1 0.126 0.999 1.000 280 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), AMT(1), ATIC(2), ATP6V0C(1), GART(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2) 4921193 33 30 33 9 3 13 8 5 4 0 0.372 0.999 1.000 281 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(4), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NFKB1(2), PIK3CA(21), PIK3R1(5), RB1(8), SP1(1) 5418502 56 44 48 13 8 19 7 5 17 0 0.306 0.999 1.000 282 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2G2(1), UBE2H(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(3) 2941220 16 15 16 5 1 7 0 5 3 0 0.664 1.000 1.000 283 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(1), AGTR2(2), EDNRA(1), EDNRB(3), EGF(4), EGFR(5), FOS(1), HRAS(1), JUN(1), NFKB1(2), PLCG1(5), PRKCA(1) 5583048 34 32 34 8 7 15 5 2 5 0 0.192 1.000 1.000 284 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNGT1(1), HTR2C(1), PLCB1(3), TUB(3) 1946427 11 11 11 5 2 3 1 3 2 0 0.802 1.000 1.000 285 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), HIBCH(4), SRM(3) 7344068 45 37 45 9 14 19 3 3 6 0 0.0527 1.000 1.000 286 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(3), ADCY9(6), ARF1(1), ARF4(1), ARF5(1), ARF6(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), GNAS(16), PDIA4(3), PLCG1(5), PLCG2(3), PRKCA(1), SEC61A1(3), SEC61A2(1), TRIM23(2) 10180114 67 55 66 12 25 20 7 8 7 0 0.0162 1.000 1.000 287 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), LPO(3), MAOA(2), MAOB(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TAT(2), TPO(8) 6134079 45 40 45 10 15 8 4 7 11 0 0.0847 1.000 1.000 288 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(1), BIRC3(2), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), PRF1(4), SCAP(4), SREBF1(3), SREBF2(2) 4969809 30 28 30 8 8 11 2 4 5 0 0.370 1.000 1.000 289 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GLS(2), GLUD1(1), GLUL(2), GMPS(3), GPT(4), GPT2(1), NADSYN1(2), QARS(3) 9126465 57 46 57 10 13 19 8 8 9 0 0.0559 1.000 1.000 290 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), RFK(1), TYR(3) 2694367 19 19 19 7 2 9 3 2 3 0 0.729 1.000 1.000 291 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CRY1(1), CRY2(2), CSNK1D(1), CSNK1E(1), NPAS2(4), NR1D1(2), PER1(5), PER2(5), PER3(5) 4614200 28 22 28 7 8 13 2 1 4 0 0.174 1.000 1.000 292 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 2740879 19 15 19 6 5 10 1 1 2 0 0.461 1.000 1.000 293 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 2740879 19 15 19 6 5 10 1 1 2 0 0.461 1.000 1.000 294 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(2), LDHAL6A(3), LDHAL6B(1), SDS(1), SULT1C2(2) 3507694 14 11 14 4 5 6 0 2 1 0 0.386 1.000 1.000 295 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(4), AKT2(1), AKT3(2), ILK(2), MAPK1(1), PIK3CA(21), PIK3CD(5), PTEN(7), PTK2B(4), RBL2(4), SOS1(3) 5503879 54 44 46 12 5 24 6 9 9 1 0.210 1.000 1.000 296 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM3(1), CCR5(1), CXCR4(1), FOS(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(1), PLCG1(5), PRKCA(1), PTK2B(4), SYT1(3) 3755123 21 21 21 6 6 7 2 1 5 0 0.425 1.000 1.000 297 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(4), MAF(1), MAPK14(1), NFATC1(4), NFATC2(6), PRKAR1B(2), PRKAR2B(3) 3262568 21 16 21 7 7 4 3 1 6 0 0.555 1.000 1.000 298 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(4), LARS(4), LARS2(2), PDHA2(5) 2698533 15 15 15 5 1 4 4 3 3 0 0.717 1.000 1.000 299 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(3), NFKB1(2), NOX1(1), XDH(9) 2757859 15 15 15 5 0 6 5 1 3 0 0.642 1.000 1.000 300 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(2), PLCB1(3), PRKCA(1) 2262604 7 7 7 5 0 4 0 1 2 0 0.942 1.000 1.000 301 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(4), AVP(1), CABIN1(8), CALM3(1), CAMK1(1), CAMK1G(2), HDAC5(2), IGF1(1), IGF1R(4), INSR(9), MAPK14(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1), NFATC1(4), NFATC2(6), PIK3CA(21), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3) 9542446 87 65 78 19 22 28 10 7 20 0 0.0292 1.000 1.000 302 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), TNFAIP3(5), TRAF3(1), TRAF6(1) 5059398 30 24 30 7 3 8 4 6 9 0 0.506 1.000 1.000 303 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), COPA(8), GBF1(5), GPLD1(2), KDELR1(1), KDELR2(2) 4447722 25 21 25 7 6 7 4 5 3 0 0.463 1.000 1.000 304 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(6), GPR18(1), GPR34(1), GPR39(1), GPR45(1), GPR68(1), GPR75(1) 2554947 13 12 13 5 5 3 4 1 0 0 0.551 1.000 1.000 305 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9) 2887395 19 18 19 7 1 12 2 1 3 0 0.506 1.000 1.000 306 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CXCR3(1), ETV5(2), IFNG(1), IL12B(1), IL12RB2(5), IL18R1(1), JAK2(2), JUN(1), MAPK14(1), MAPK8(1), STAT4(5), TYK2(3) 5190287 26 25 26 7 5 8 3 5 5 0 0.444 1.000 1.000 307 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP3A43(1), CYP3A5(2), CYP3A7(1), DHRS1(1), DHRS3(2), DHRSX(1), PON1(1), PON2(2), PON3(4) 4956073 26 23 26 7 5 6 5 3 7 0 0.415 1.000 1.000 308 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), SQLE(1), VKORC1(1) 3085867 16 15 16 5 2 8 2 1 3 0 0.554 1.000 1.000 309 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), GGCX(2), HMGCR(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), SQLE(1), VKORC1(1) 5318329 24 23 24 5 5 13 1 1 4 0 0.195 1.000 1.000 310 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(4), ALOX5AP(1), DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), PTGS1(2), TBXAS1(2) 4389941 24 20 24 7 12 5 1 1 5 0 0.343 1.000 1.000 311 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(2), FOSL2(1), IFNAR1(1), IFNB1(1), MAPK8(1), NFKB1(2), TNFRSF11A(1), TRAF6(1) 3042812 11 10 11 4 1 4 2 0 4 0 0.745 1.000 1.000 312 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(2), HRAS(1), INSR(9), IRS1(6), JAK2(2), MAP2K1(2), MAPK1(1), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RPS6KA1(1), SOS1(3), STAT5A(3), STAT5B(2) 9085069 67 57 59 14 13 25 9 9 11 0 0.0785 1.000 1.000 313 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2) 4287148 10 10 10 2 2 3 1 0 4 0 0.536 1.000 1.000 314 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), BTRC(3), CDC20(3), CDC23(1), CDC26(1), CDC27(7), CUL1(4), CUL2(1), CUL3(3), FBXW7(14), FZR1(4), ITCH(3), SMURF1(2), SMURF2(2), UBA1(4), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), WWP1(6), WWP2(3) 11165380 81 57 79 16 10 26 6 14 24 1 0.166 1.000 1.000 315 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5A(2), GPRC5B(3), GPRC5C(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM7(3), GRM8(11) 5612865 60 49 60 16 20 17 8 7 8 0 0.135 1.000 1.000 316 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRK(1), DOCK1(9), ELK1(2), FOS(1), GAB1(1), HGF(2), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), MET(4), PAK1(2), PIK3CA(21), PIK3R1(5), PTEN(7), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAF1(2), RAP1A(1), RASA1(9), SOS1(3), STAT3(2) 12538330 96 71 88 20 13 45 9 11 17 1 0.0520 1.000 1.000 317 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(8), PGM1(1), PYGL(3), PYGM(4) 3816428 17 14 17 5 3 8 2 1 3 0 0.500 1.000 1.000 318 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3) 6288927 57 46 57 13 16 18 5 3 15 0 0.152 1.000 1.000 319 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3) 6288927 57 46 57 13 16 18 5 3 15 0 0.152 1.000 1.000 320 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(4), AKT2(1), AKT3(2), BCR(4), BTK(1), CDKN2A(19), DAPP1(1), FLOT2(5), GAB1(1), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), NR0B2(1), PIK3CA(21), PITX2(1), PLCG2(3), PPP1R13B(4), PREX1(5), PTEN(7), PTPRC(9), RPS6KA1(1), RPS6KA2(1), SAG(1), SYK(2), TEC(1), VAV1(8) 15437326 121 87 112 23 18 46 13 17 26 1 0.00660 1.000 1.000 321 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(2), CR2(4), FCGR2B(1), HLA-DRB1(1), ICAM1(1), ITGAL(6), PTPRC(9) 4195132 25 24 24 9 3 11 2 2 7 0 0.650 1.000 1.000 322 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(4), AKT2(1), AKT3(2), BRD4(8), CBL(6), CDKN2A(19), F2RL2(1), FLOT2(5), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), LNPEP(3), MAPK1(1), PARD3(7), PARD6A(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PTEN(7), PTPN1(5), RAF1(2), RPS6KA1(1), RPS6KA2(1), SERPINB6(1), SORBS1(7), SOS1(3), SOS2(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 16042355 142 92 133 29 28 44 14 15 40 1 0.0219 1.000 1.000 323 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCKDHA(2), BCKDHB(3), ECHS1(1), EHHADH(1), HADHA(2), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1) 9879172 63 51 63 12 11 28 6 2 16 0 0.0882 1.000 1.000 324 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1) 2400666 11 9 11 6 2 4 1 2 2 0 0.880 1.000 1.000 325 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), PDE1A(3), PDE1B(3), PLCB1(3), PLCB2(1), PRL(2), VIP(2) 3016367 21 20 21 9 8 4 5 1 3 0 0.740 1.000 1.000 326 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT4(3), AGPAT6(1), AGPS(4), ENPP6(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3) 6522519 36 32 34 9 10 12 5 2 7 0 0.306 1.000 1.000 327 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(3), CASP9(1), DAXX(3), FASLG(1), HSPB2(1), MAPKAPK2(1) 3069836 11 10 11 8 3 2 2 1 3 0 0.959 1.000 1.000 328 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(6), ITGAM(3), SELE(3), SELL(1) 2959112 14 14 13 9 3 6 1 1 3 0 0.906 1.000 1.000 329 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CRK(1), CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(1), NFKB1(2), PIK3C2G(4), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PTK2B(4), PXN(3), RAF1(2) 7793307 63 49 55 14 11 27 7 8 10 0 0.0957 1.000 1.000 330 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), RFK(1), TYR(3) 4151358 27 24 26 9 2 13 4 2 6 0 0.673 1.000 1.000 331 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MIOX(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CA(21), PIK3CB(4), PIK3CG(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3) 12508173 83 61 75 14 12 43 6 10 12 0 0.00707 1.000 1.000 332 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(3), CSF1(1), FCGR3A(1), IL1B(3), IL6R(1), SELL(1), SPN(1), TGFB2(1), TNFRSF1B(1), TNFRSF8(5) 3828853 18 16 18 6 4 6 3 1 4 0 0.415 1.000 1.000 333 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9) 3044520 19 18 19 8 1 12 2 1 3 0 0.619 1.000 1.000 334 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(5), ERBB3(6), NRG1(8), UBE2D1(1) 2803358 24 22 23 9 4 11 6 1 2 0 0.661 1.000 1.000 335 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3E(1), CXCR3(1), IFNG(1), IL12B(1), IL12RB2(5), JAK2(2), STAT4(5), TYK2(3) 4090422 21 21 21 7 3 7 3 4 4 0 0.595 1.000 1.000 336 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), JUN(1), OPRK1(2), POLR2A(3), PRKAR1B(2), PRKAR2B(3) 3486334 12 11 12 6 3 4 1 0 4 0 0.854 1.000 1.000 337 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(4), ACOX3(1), ELOVL2(2), ELOVL5(2), ELOVL6(2), FADS1(1), FADS2(2), FASN(7), HADHA(2), SCD(3) 4151496 26 20 25 9 4 10 0 3 9 0 0.579 1.000 1.000 338 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH4A1(4), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), DAO(1), GAMT(1), GATM(2), GLUD1(1), MAOA(2), MAOB(3), NOS1(6), NOS3(5), OAT(3), ODC1(1), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(2), RARS(4) 12237731 89 67 89 17 26 26 9 8 20 0 0.0149 1.000 1.000 339 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2) 2855337 10 10 10 4 4 3 1 2 0 0 0.697 1.000 1.000 340 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL6(1), IL6R(1), IL6ST(5), JAK1(3), JAK2(2), JAK3(6), JUN(1), MAP2K1(2), PTPN11(2), RAF1(2), SOS1(3), STAT3(2) 6652040 35 32 35 9 11 10 4 6 4 0 0.278 1.000 1.000 341 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(3), JAK2(2), JAK3(6), SOCS3(1), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), TYK2(3) 5227685 31 26 30 9 10 7 3 4 7 0 0.373 1.000 1.000 342 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(5), ARHGEF1(3), F2(4), F2R(4), F2RL3(2), GNA12(1), GNA13(3), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(3), PIK3CA(21), PIK3R1(5), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2B(4), ROCK1(2) 7113041 65 52 56 15 7 26 8 9 15 0 0.216 1.000 1.000 343 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL16(3), IL3(2), IL6(1) 2684908 12 8 12 5 3 5 1 2 1 0 0.609 1.000 1.000 344 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), HK1(1), PFKL(1), PGK1(1), PKLR(3) 2579841 9 8 9 6 3 2 2 0 2 0 0.867 1.000 1.000 345 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(8), ACADL(5), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1), SUCLG1(2), SUCLG2(1) 9053586 54 44 53 11 13 18 7 3 13 0 0.177 1.000 1.000 346 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD2(1), CD33(2), CD5(2), CD7(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL3(2), ITGAX(2), TLR2(5), TLR4(6), TLR7(1) 4935203 28 23 28 9 4 10 8 1 5 0 0.473 1.000 1.000 347 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCRL(1), CD97(3), CRHR1(2), ELTD1(4), EMR1(7), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(9), LPHN3(9) 7493484 47 39 45 10 7 16 11 4 9 0 0.0695 1.000 1.000 348 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(2), GNE(1), HK1(1), HK2(3), HK3(2), RENBP(2), UAP1(1) 4695914 14 14 14 4 5 5 0 1 3 0 0.450 1.000 1.000 349 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), KMO(1), KYNU(2), MAOA(2), MAOB(3), SDS(1), TDO2(1), TPH1(2), WARS(1), WARS2(2) 15254187 96 69 96 18 27 35 5 12 17 0 0.00893 1.000 1.000 350 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), JAK1(3), JAK3(6), JUN(1), LCK(1), MAP2K1(2), MAPK8(1), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 6605526 35 27 35 8 11 8 4 7 5 0 0.228 1.000 1.000 351 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ACAT1(3), ACAT2(1), ACYP1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PDHA2(5), PKLR(3) 10065443 60 49 60 12 15 25 7 3 10 0 0.0572 1.000 1.000 352 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), NGFR(2), RAF1(2) 2324362 15 15 15 7 7 5 2 1 0 0 0.610 1.000 1.000 353 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(15), AXIN1(2), AXIN2(2), BTRC(3), CACYBP(2), CAMK2A(3), CAMK2B(2), CCND1(1), CER1(1), CHD8(9), CREBBP(13), CSNK1A1(2), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CSNK2A2(1), CTBP2(2), CTNNB1(9), CTNNBIP1(1), CUL1(4), CXXC4(1), DAAM1(6), DAAM2(6), DKK2(3), DKK4(2), DVL2(1), DVL3(2), EP300(12), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LRP5(4), LRP6(8), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKD2(5), NLK(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PORCN(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRICKLE1(4), PRICKLE2(2), PRKACA(3), PRKCA(1), PRKCG(2), PSEN1(2), RAC1(1), RHOA(3), ROCK1(2), ROCK2(4), SENP2(3), SFRP1(2), SFRP2(1), SFRP4(3), SMAD2(2), SMAD3(3), SMAD4(14), SOX17(3), TBL1X(2), TBL1XR1(3), TCF7L1(2), TP53(174), VANGL1(3), VANGL2(4), WIF1(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2) 43675580 478 175 403 73 130 121 54 45 124 4 2.71e-11 1.000 1.000 354 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), RAC1(1), WASF1(3), WASL(2) 2270085 8 8 8 5 2 1 1 3 1 0 0.937 1.000 1.000 355 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(5), MAPK14(1), MAPK8(1), NFKB1(2), TNFSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1) 4059716 16 14 16 5 2 6 1 2 5 0 0.701 1.000 1.000 356 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(3), ARRB2(1), CALM3(1), CAMK2A(3), CAMK2B(2), CLCA2(4), CLCA4(2), CNGA3(4), CNGA4(1), CNGB1(2), GNAL(2), GUCA1A(1), GUCA1B(2), GUCA1C(2), PDE1C(3), PRKACA(3), PRKG1(3), PRKG2(5) 8420096 47 41 47 10 10 16 12 1 8 0 0.106 1.000 1.000 357 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), NCK1(1), NCKAP1(4), NTRK1(5), PIR(2), PSMA7(1), RAC1(1), WASF1(3), WASF2(3), WASF3(3), WASL(2) 4259659 27 25 27 9 8 5 3 6 5 0 0.674 1.000 1.000 358 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(1), CALM3(1), CD79A(2), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK14(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), RAC1(1), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8) 10386054 73 55 73 15 21 22 8 6 16 0 0.0604 1.000 1.000 359 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(2), ENDOG(1), HMGB1(1), HMGB2(1), TOP2A(7), TOP2B(8) 2919291 22 20 22 8 5 13 2 1 1 0 0.783 1.000 1.000 360 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS3(2), DHRSX(1), HEMK1(1), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1) 4060680 16 14 16 5 3 6 1 1 5 0 0.589 1.000 1.000 361 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(2), HEMK1(1), LCMT1(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), METTL2B(1), PAPSS2(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SCLY(2), SEPHS1(3), SEPHS2(2) 6934007 31 24 31 7 7 11 3 4 6 0 0.173 1.000 1.000 362 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), CSF3(2), HLA-DRB1(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL3(2), IL6(1), PDGFA(2), TGFB2(1), TGFB3(2) 3721512 18 16 18 8 4 6 2 2 4 0 0.819 1.000 1.000 363 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(3), PPARA(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3) 5740051 29 27 29 9 11 8 1 1 8 0 0.361 1.000 1.000 364 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(9), DDX20(1), E2F1(2), ETS1(1), ETV3(3), FOS(1), HDAC5(2), HRAS(1), JUN(1), NCOR2(12), RBL1(2), RBL2(4), SIN3A(5), SIN3B(3) 7486294 48 41 48 11 10 18 5 5 10 0 0.185 1.000 1.000 365 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(1), GTF2F1(5), GTF2H1(1), GTF2H3(1), GTF2I(2), GTF2IRD1(6), STON1(3), TAF1(5), TAF10(1), TAF1L(8), TAF2(5), TAF4(2), TAF4B(3), TAF5(2), TAF5L(5), TAF6(1), TAF6L(2), TAF7(1), TAF7L(2), TAF9B(1), TBPL1(1), TBPL2(2) 9865842 62 53 62 14 10 21 14 9 8 0 0.154 1.000 1.000 366 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), C1GALT1(1), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GCNT1(3), GCNT3(1), GCNT4(4), OGT(3), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(2), WBSCR17(10) 8858614 62 54 62 15 16 15 14 9 8 0 0.175 1.000 1.000 367 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), GCK(1), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(2), PFKFB4(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1) 6640440 35 28 35 9 10 13 2 3 7 0 0.195 1.000 1.000 368 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3) 3740337 14 14 13 6 4 5 1 1 3 0 0.768 1.000 1.000 369 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), F10(2), F11(4), F12(2), F2(4), F2R(4), F5(4), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), PROC(1), PROS1(5), SERPING1(2) 12194676 74 55 73 14 14 29 9 9 13 0 0.0690 1.000 1.000 370 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(1), GCLC(1), GCLM(1), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), PGD(1) 5094863 14 14 14 4 2 8 1 2 1 0 0.429 1.000 1.000 371 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(4), B3GNT2(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST1(1), CHST6(2), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1) 3305825 24 22 24 9 6 8 5 4 1 0 0.599 1.000 1.000 372 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), XYLB(1) 7374600 24 23 24 5 5 10 3 3 3 0 0.214 1.000 1.000 373 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 GORASP1(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK5(2), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CD(5), PIK3R1(5), SYT1(3), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1) 9534485 64 51 56 14 13 21 6 7 17 0 0.0977 1.000 1.000 374 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME3(1), PGK1(1), PGK2(1), PKLR(3), RPE(1), RPIA(1), TKT(1), TKTL1(1) 5417427 28 25 28 9 7 10 1 3 7 0 0.514 1.000 1.000 375 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACSS1(2), ACSS2(8), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(4), LDHAL6A(3), LDHAL6B(1), MCEE(1), MUT(3), PCCA(3), PCCB(1), SUCLG1(2), SUCLG2(1) 10835069 67 54 66 15 15 28 5 7 12 0 0.143 1.000 1.000 376 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BIRC2(1), BIRC3(2), CASP8(6), CFLAR(2), FADD(1), JUN(1), MAP2K4(3), MAP3K3(1), MAP3K7(3), NFKB1(2), NFKB2(2), NR2C2(4), RALBP1(2), RIPK1(2), TNFAIP3(5), TNFRSF1B(1), TRAF2(1) 7723449 39 30 38 9 9 11 2 7 10 0 0.213 1.000 1.000 377 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(4), BCR(4), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOS1(3), STAT1(3), STAT5A(3), STAT5B(2) 7723257 66 48 58 16 11 25 7 10 13 0 0.216 1.000 1.000 378 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(4), AKT2(1), AKT3(2), BRAF(4), EIF4EBP1(1), HIF1A(5), IGF1(1), MAPK1(1), PGF(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRKAA1(2), PRKAA2(1), RHEB(1), RICTOR(6), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), STK11(5), TSC1(10), TSC2(7), ULK1(3), ULK2(2), ULK3(3), VEGFC(5) 14795621 115 77 107 24 18 41 17 13 25 1 0.0244 1.000 1.000 379 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(2), JAK3(6), MAPK1(1), STAT3(2), TYK2(3) 3333906 17 17 17 7 4 3 4 4 2 0 0.803 1.000 1.000 380 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), BDH1(1), BDH2(4), DDHD1(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADH(1), HADHA(2), HMGCS2(2), HSD17B4(4), HSD3B7(2), ILVBL(1), L2HGDH(3), OXCT2(1), PDHA2(5), PLA1A(1), PPME1(1), PRDX6(3), RDH13(1) 11194529 67 51 67 14 12 31 4 7 13 0 0.0635 1.000 1.000 381 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACOT12(2), ACSS1(2), ACSS2(8), ACYP1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6A(3), LDHAL6B(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PCK2(2), PDHA2(5), PKLR(3) 12696780 80 61 80 17 18 36 7 7 12 0 0.0350 1.000 1.000 382 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(5), ASRGL1(2), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), HAL(1) 5799709 40 32 40 11 3 15 7 7 8 0 0.424 1.000 1.000 383 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(15), AXIN1(2), BMP10(1), BMP2(1), BMP5(1), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(5), CTNNB1(9), FZD1(4), GSK3B(3), MAP3K7(3), MEF2C(2), NKX2-5(3), NOG(1), RFC1(5), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TGFBR3(3), WNT1(1) 9790669 86 62 81 22 14 22 15 10 24 1 0.433 1.000 1.000 384 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(4), BCL2L1(1), CBL(6), CFLAR(2), E2F1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), IRS1(6), JAK1(3), JAK3(6), MAPK1(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOCS3(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 10105007 76 54 68 17 11 25 10 18 12 0 0.134 1.000 1.000 385 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(2), EPOR(2), HIF1A(5), JAK2(2), NFKB1(2) 3532655 13 13 13 6 2 6 0 3 2 0 0.810 1.000 1.000 386 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), IDUA(1), LCT(8), NAGLU(3) 4024338 21 18 21 8 5 6 4 3 3 0 0.727 1.000 1.000 387 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), RIPK1(2), TANK(3), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1) 6170506 38 31 38 10 8 8 5 8 9 0 0.485 1.000 1.000 388 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), ESCO1(3), ESCO2(1), LPO(3), MAOA(2), MAOB(3), MIF(1), MPO(3), PRDX6(3), SH3GLB1(2), TAT(2), TPO(8) 9280965 49 42 49 11 16 10 3 6 14 0 0.105 1.000 1.000 389 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), ALDOC(4), FBP2(2), H6PD(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1) 5514466 26 24 26 8 5 13 2 3 3 0 0.408 1.000 1.000 390 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AOC2(4), AOC3(5), ASPA(2), DDC(2), HAL(1), HARS(1), HDC(2), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(2) 6689348 46 38 46 13 14 11 5 8 8 0 0.318 1.000 1.000 391 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(4), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCAT2(2), BCKDHA(2), BCKDHB(3), DBT(2), DLD(4), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HIBCH(4), HMGCS2(2), HSD17B4(4), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), OXCT2(1), PCCA(3), PCCB(1) 11874394 69 55 69 15 10 37 5 2 15 0 0.153 1.000 1.000 392 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), HRAS(1), JUN(1), MAP2K1(2), MAPK1(1), NFKB1(2), PLCB1(3), PRKCA(1), RAF1(2) 4229590 14 14 14 9 3 5 2 1 3 0 0.941 1.000 1.000 393 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1) 6344405 38 30 38 10 11 10 5 1 11 0 0.350 1.000 1.000 394 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(5), MAP2K1(2), MAP3K1(8), MAPK14(1), NCOR2(12), THRA(6), THRB(1) 4838135 39 31 39 12 12 14 4 2 7 0 0.414 1.000 1.000 395 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(5), EPRS(3), GARS(3), HARS(1), IARS(4), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), QARS(3), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(2), YARS(1) 8665429 50 41 50 12 12 20 6 7 5 0 0.208 1.000 1.000 396 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(1), RPL10L(5), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(1), RPL6(1), RPL8(2), RPS10(1), RPS11(2), RPS13(2), RPS24(1), RPS26(2), RPS5(2), RPS9(1) 6461598 39 30 39 9 9 10 5 7 8 0 0.391 1.000 1.000 397 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(5), AASS(3), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADHA(2), PLOD1(3), PLOD2(3), PLOD3(4), SDS(1), SHMT1(2), SHMT2(2), TMLHE(1) 10130832 70 55 70 17 15 31 8 3 13 0 0.131 1.000 1.000 398 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), AMT(1), ATIC(2), FTCD(2), GART(2), MTFMT(1), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2) 5220380 35 31 35 11 4 12 8 5 6 0 0.553 1.000 1.000 399 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(3), PRPS2(2), SRM(3) 3588424 16 12 16 6 7 2 2 2 3 0 0.670 1.000 1.000 400 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(1), BIN1(1), CALM3(1), DNM1(4), EPN1(4), EPS15(3), PICALM(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYNJ1(7), SYNJ2(4), SYT1(3) 6288611 39 35 39 11 8 12 3 2 13 1 0.389 1.000 1.000 401 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(1), GCLC(1), GCLM(1), GPX7(1), GSR(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), OPLAH(3) 6208281 23 23 23 6 5 10 1 4 3 0 0.350 1.000 1.000 402 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), AKT1(4), GNAI1(1), GNGT1(1), ITGAV(5), ITGB3(2), MAPK1(1), PDGFA(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLCB1(3), PRKCA(1), PTK2(1), RAC1(1), SMPD1(2) 7472692 59 45 51 15 10 21 8 7 13 0 0.239 1.000 1.000 403 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 CASP2(2), CHUK(5), CRADD(1), IKBKB(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP4K2(4), MAPK14(1), MAPK8(1), NFKB1(2), RIPK1(2), TANK(3), TRAF2(1) 6736502 36 32 36 10 6 10 6 5 9 0 0.514 1.000 1.000 404 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12(2), ALOX12B(4), ALOX15(2), ALOX15B(2), ALOX5(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP2U1(2), CYP4A22(2), CYP4F2(4), CYP4F3(1), DHRS4(2), EPHX2(2), GPX7(1), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2) 11142820 61 45 61 13 22 22 4 4 9 0 0.0343 1.000 1.000 405 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4) 5545815 36 30 36 11 7 18 5 1 5 0 0.395 1.000 1.000 406 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREBBP(13), EP300(12), NCOA3(3), PRKAR1B(2), PRKAR2B(3) 5579274 35 28 35 11 5 13 3 1 13 0 0.664 1.000 1.000 407 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(2), CCND1(1), CREBBP(13), EP300(12), ERCC3(1), ESR1(6), GRIP1(4), GTF2E1(1), GTF2F1(5), HDAC1(1), HDAC3(3), HDAC4(12), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(12), NR0B1(1), NRIP1(3), PELP1(3), POLR2A(3), TBP(2) 12822425 98 65 93 24 28 32 8 6 24 0 0.0851 1.000 1.000 408 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM3(1), ELK1(2), FOS(1), GNAI1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAF1(2), SYT1(3) 9508983 70 57 70 17 23 22 7 4 14 0 0.118 1.000 1.000 409 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(16), GNGT1(1), PPP2CA(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAR1B(2), PRKAR2B(3) 4211293 37 35 37 11 11 11 5 3 7 0 0.523 1.000 1.000 410 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), CHUK(5), ELK1(2), FOS(1), IKBKB(2), IRAK1(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), PPARA(1), TLR10(3), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TOLLIP(1), TRAF6(1) 9938613 53 46 52 13 5 14 13 7 14 0 0.341 1.000 1.000 411 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR2(2), CMA1(1), COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), REN(2) 7056935 38 33 38 11 8 18 3 4 5 0 0.511 1.000 1.000 412 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(3), ATG7(4), BECN1(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNG(1), PIK3C3(1), PRKAA1(2), PRKAA2(1), ULK1(3), ULK2(2), ULK3(3) 5863242 25 23 25 9 4 10 4 3 4 0 0.746 1.000 1.000 413 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(4), AKT2(1), AKT3(2), BTK(1), FYN(1), GAB2(2), HRAS(1), IL3(2), INPP5D(4), KRAS(3), LCP2(4), LYN(2), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MS4A2(1), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCD(2), PRKCE(2), RAC1(1), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8), VAV2(1), VAV3(2) 19975267 133 91 123 26 32 55 16 11 19 0 0.00309 1.000 1.000 414 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX15(2), ALOX5(4), CYP4F2(4), CYP4F3(1), EPX(2), LPO(3), LTA4H(1), MPO(3), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PRDX1(2), PRDX2(1), PRDX6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2), TPO(8) 7948482 52 43 52 14 20 15 5 3 9 0 0.156 1.000 1.000 415 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACAT2(1), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), FN3K(2), GCDH(1), HADHA(2), SH3GLB1(2), YOD1(1) 6940979 24 23 24 7 3 12 2 0 7 0 0.627 1.000 1.000 416 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(2), ANXA5(3), ANXA6(1), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(1), HSD11B2(1), PLA2G4A(1), PRL(2), PTGDS(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), PTGIS(2), PTGS1(2), TBXAS1(2) 5619371 33 27 33 10 9 11 4 4 5 0 0.459 1.000 1.000 417 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(4), F12(2), F13B(3), F2(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), LPA(10), PLAT(1), PLG(3), SERPINB2(2), SERPINF2(2), VWF(9) 9584006 63 49 62 16 14 21 10 3 15 0 0.272 1.000 1.000 418 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(4), AKT2(1), AKT3(2), CASP9(1), HRAS(1), KDR(5), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NOS3(5), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PRKCG(2), PTK2(1), PXN(3), RAC1(1), RAF1(2), SH2D2A(1), SPHK2(3) 20043983 134 85 125 25 32 57 13 13 19 0 0.00111 1.000 1.000 419 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(6), EEF1A2(1), EEF1G(1), EEF2(5), EEF2K(4), EIF1AY(1), EIF2AK1(2), EIF2AK3(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(6), EIF4G3(4), EIF5B(6), PABPC1(2), PABPC3(5), PAIP1(1) 12225376 63 50 60 14 9 22 7 9 16 0 0.162 1.000 1.000 420 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), P4HB(2), SLC23A1(1), SLC23A2(4), SLC2A1(1), SLC2A3(1) 7089803 38 31 38 12 7 17 4 5 5 0 0.528 1.000 1.000 421 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(6), EGF(4), EGFR(5), HRAS(1), MAP2K1(2), MAPK1(1), PTPRB(2), RAF1(2), RASA1(9), SOS1(3), SPRY4(2) 6892034 37 30 37 11 6 15 5 6 5 0 0.523 1.000 1.000 422 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), SOAT2(1) 6362072 40 33 40 14 13 10 5 3 9 0 0.549 1.000 1.000 423 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTAP(2), MTFMT(1), MTR(7), SRM(3), TAT(2) 5743274 35 28 35 11 8 11 2 6 8 0 0.470 1.000 1.000 424 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), BHMT(3), CHDH(1), CHKB(1), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), HSD3B7(2), MAOA(2), MAOB(3), PHGDH(1), PIPOX(1), PISD(1), PSAT1(3), PSPH(2), RDH13(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT1(2), SHMT2(2), TARS(6), TARS2(2) 12051986 67 49 67 16 15 30 6 7 9 0 0.0674 1.000 1.000 425 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), PON1(1) 8200350 47 39 47 13 10 18 4 6 9 0 0.232 1.000 1.000 426 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(4), AKT2(1), AKT3(2), ANKRD6(2), APC(15), AXIN1(2), AXIN2(2), CER1(1), CSNK1A1(2), CTNNB1(9), DACT1(2), DKK2(3), DKK3(1), DKK4(2), FRAT1(1), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(8), MVP(3), NKD2(5), PSEN1(2), PTPRA(4), SENP2(3), SFRP1(2), TSHB(2), WIF1(2) 11232811 88 65 85 23 20 26 11 9 21 1 0.239 1.000 1.000 427 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(3), ACAT2(1), AFMID(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CARM1(2), CYP1A1(3), CYP1A2(1), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HEMK1(1), HSD17B4(4), KMO(1), KYNU(2), LCMT1(1), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(3), OGDH(2), OGDHL(6), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(1), WARS2(2) 16676454 91 65 91 20 29 36 2 10 14 0 0.0296 1.000 1.000 428 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(5), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUL(2), HAL(1) 5202756 34 27 34 11 1 12 7 7 7 0 0.653 1.000 1.000 429 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), ATP6V0C(1), BHMT(3), CHDH(1), CHKB(1), CPT1B(6), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), MAOA(2), MAOB(3), PISD(1), PLCB2(1), PLCG1(5), PLCG2(3), PSPH(2), SARDH(2), SARS(2), SHMT1(2), SHMT2(2), TARS(6) 11752292 71 53 70 17 18 31 6 5 11 0 0.0608 1.000 1.000 430 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(2), ENPP1(5), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5C1A(1), NT5C1B(2), NT5M(1), NUDT12(1) 5925817 33 29 33 11 3 17 0 6 7 0 0.648 1.000 1.000 431 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BTRC(3), CSNK1A1(2), CSNK1A1L(1), CSNK1D(1), CSNK1E(1), CSNK1G2(1), GAS1(2), GLI1(5), GLI2(5), GLI3(9), GSK3B(3), HHIP(4), IHH(2), LRP2(20), PRKACA(3), PTCH1(13), PTCH2(4), SMO(4), STK36(3), SUFU(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(3) 16379553 116 73 115 28 30 34 12 15 25 0 0.0834 1.000 1.000 432 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM3(1), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK14(1), MAPK8(1), PAK1(2), PLCG1(5), PRKCA(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3) 7874496 50 46 50 15 14 14 5 7 10 0 0.431 1.000 1.000 433 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(4), BRAF(4), CREB5(2), CREBBP(13), DAG1(1), EGR1(2), EGR4(1), ELK1(2), FRS2(1), GNAQ(1), JUN(1), MAP1B(13), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), NTRK1(5), PIK3C2G(4), PIK3CA(21), PIK3CD(5), PIK3R1(5), PTPN11(2), TERF2IP(1), TH(3) 14127862 106 75 98 29 21 37 10 14 24 0 0.201 1.000 1.000 434 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACADVL(2), ACAT1(3), ACAT2(1), ACOX1(4), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP4A22(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(4) 13373244 74 57 73 19 21 32 2 3 16 0 0.150 1.000 1.000 435 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), CREB5(2), DUSP10(3), EEF2K(4), ELK1(2), IL1R1(1), MAP2K4(3), MAP3K10(4), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(2), NFKB1(2), NR2C2(4), TRAF6(1) 9368323 58 40 56 16 20 17 6 5 10 0 0.206 1.000 1.000 436 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1) 14498774 92 62 91 22 20 30 25 6 11 0 0.0659 1.000 1.000 437 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1) 14498774 92 62 91 22 20 30 25 6 11 0 0.0659 1.000 1.000 438 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(5), FADD(1), IKBKB(2), IL1R1(1), IRAK1(2), MAP3K1(8), MAP3K7(3), NFKB1(2), RIPK1(2), TLR4(6), TNFAIP3(5), TNFRSF1B(1), TRAF6(1) 6681831 39 33 38 13 8 7 9 6 9 0 0.709 1.000 1.000 439 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), ALDOC(4), DERA(2), FBP2(2), H6PD(1), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1), TKTL1(1) 6668314 30 27 30 10 6 13 2 6 3 0 0.519 1.000 1.000 440 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS2(2), BLVRA(3), CP(3), CPOX(1), EARS2(1), EPRS(3), FECH(1), FTH1(2), FTMT(2), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), MMAB(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UROD(1), UROS(1) 11416315 49 39 49 12 12 18 6 6 7 0 0.181 1.000 1.000 441 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG5(2), ALG6(2), ALG9(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), DDOST(1), FUT8(2), GANAB(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), RFT1(1), RPN1(3), RPN2(3), STT3B(5) 11728759 66 51 66 18 11 24 10 6 15 0 0.316 1.000 1.000 442 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(1), EXTL3(3), GLCE(3), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), NDST1(5), NDST2(5), NDST3(5), NDST4(6) 5708978 45 38 45 15 12 14 8 7 4 0 0.467 1.000 1.000 443 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(2), CASP8(6), CRADD(1), DFFA(1), DFFB(2), FADD(1), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MADD(7), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), RB1(8), RIPK1(2), SPTAN1(8), TRAF2(1) 10935795 80 53 79 22 13 19 8 14 26 0 0.588 1.000 1.000 444 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), FUCA2(3), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NAGLU(3), NEU1(1), NEU2(2), NEU4(4), SPAM1(1) 9599067 58 46 58 17 11 25 7 6 9 0 0.285 1.000 1.000 445 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(4), AP2A1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), GSK3A(2), GSK3B(3), LYN(2), PFKL(1), PFKM(4), PFKP(2), PLCG1(5), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1) 7053156 36 31 36 11 12 11 6 1 6 0 0.405 1.000 1.000 446 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT2(2), B3GALT4(1), B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALNT1(3), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT6(3), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGZ(1), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1) 13370806 75 62 75 20 19 26 10 13 7 0 0.145 1.000 1.000 447 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CALR(2), CANX(1), CD74(1), CIITA(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA16(1), IFNA2(1), IFNA7(1), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRC4(1), KLRD1(2), NFYA(1), NFYB(2), NFYC(1), PDIA3(2), PSME1(1), PSME2(3), RFX5(5), RFXANK(1), RFXAP(2), TAP2(1), TAPBP(1) 12928229 82 54 82 23 14 24 13 9 22 0 0.401 1.000 1.000 448 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(8), DIAPH1(2), FYN(1), GSN(3), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), MYLK(6), PIK3CA(21), PIK3R1(5), PTK2(1), PXN(3), RAF1(2), ROCK1(2), TLN1(7) 10280703 69 58 61 20 10 31 14 7 7 0 0.337 1.000 1.000 449 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF11(1), BTK(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(2), ITPR1(6), ITPR2(8), ITPR3(2), LIMK1(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CD(5), PIK3CG(1), PIK3R1(5), PITX2(1), PPP1R13B(4), PTEN(7), RACGAP1(1), RHO(1), ROCK1(2), ROCK2(4), SAG(1), WASF1(3), WASL(2) 19353007 117 82 109 27 20 39 17 22 18 1 0.0687 1.000 1.000 450 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT4(3), AGPS(4), CDS1(1), CDS2(1), CHAT(8), CHKB(1), CPT1B(6), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD2(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB2(1), PLCG1(5), PLCG2(3), PPAP2A(2), PPAP2B(3) 14001037 80 60 79 21 28 28 5 6 13 0 0.0944 1.000 1.000 451 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(3), CMAS(1), CTBS(1), CYB5R1(1), GFPT1(2), GFPT2(3), GNE(1), HK1(1), HK2(3), HK3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), NAGK(2), NANS(3), NPL(1), RENBP(2), UAP1(1) 7946896 35 27 34 11 6 16 2 3 8 0 0.468 1.000 1.000 452 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CSK(2), DAG1(1), EPHB2(4), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), RAF1(2), SERPINA4(4), SOS1(3), SOS2(1), SYK(2), VAV1(8) 14688814 102 77 94 26 22 42 7 12 19 0 0.0868 1.000 1.000 453 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(1), CDK2(1), CDT1(1), DIAPH2(8), MCM10(2), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), NACA(7), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), PRIM1(4), RFC1(5), RFC3(3), RFC4(1), RFC5(1), RPA1(3), RPA4(3) 13848527 74 52 74 19 10 29 9 14 12 0 0.254 1.000 1.000 454 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ADAM17(3), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), CCL5(1), CHUK(5), CSK(2), CXCL1(1), EGFR(5), IKBKB(2), JAM3(1), JUN(1), LYN(2), MAP2K4(3), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(5), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), TCIRG1(1), TJP1(6) 19415392 93 70 93 21 18 30 13 15 17 0 0.100 1.000 1.000 455 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(2), AKT1(4), AKT2(1), AKT3(2), ARRB1(5), ARRB2(1), ATF4(2), BDNF(3), BRAF(4), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CACNA2D1(5), CACNA2D2(2), CACNA2D3(8), CACNA2D4(6), CACNB1(2), CACNB2(1), CACNG2(1), CACNG3(1), CACNG4(2), CACNG5(4), CACNG6(2), CACNG8(2), CD14(1), CDC25B(2), CHUK(5), CRK(1), DAXX(3), DUSP10(3), DUSP4(1), DUSP5(1), DUSP6(1), DUSP7(2), DUSP9(2), ECSIT(2), EGF(4), EGFR(5), ELK1(2), ELK4(1), FASLG(1), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FLNA(3), FLNB(4), FLNC(10), FOS(1), GADD45B(2), GNA12(1), HRAS(1), IKBKB(2), IL1B(3), IL1R1(1), IL1R2(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAPT(1), MAX(1), MEF2C(2), MKNK1(1), MKNK2(2), MRAS(1), NF1(8), NFATC2(6), NFATC4(4), NFKB1(2), NFKB2(2), NLK(4), NR4A1(1), NRAS(1), NTRK1(5), NTRK2(6), PAK1(2), PAK2(1), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PPP5C(2), PRKACA(3), PRKCA(1), PRKCG(2), PTPN7(1), PTPRR(6), RAC1(1), RAF1(2), RAP1A(1), RAPGEF2(4), RASA1(9), RASA2(2), RASGRF1(9), RASGRF2(5), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(4), SOS1(3), SOS2(1), STK4(2), STMN1(1), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TP53(174), TRAF2(1), TRAF6(1), ZAK(4) 81492956 702 180 625 157 195 180 75 71 177 4 2.58e-07 1.000 1.000 456 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), C5AR1(1), CALCRL(1), CCKAR(1), CCKBR(3), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CNR1(3), CNR2(1), CRHR1(2), CYSLTR1(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2(4), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GABBR1(2), GABBR2(3), GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GABRB1(7), GABRB2(1), GABRB3(4), GABRE(3), GABRG1(5), GABRG2(4), GABRG3(2), GABRP(1), GABRR2(1), GALR1(2), GALR2(3), GALR3(1), GH1(1), GH2(2), GHR(2), GHRHR(2), GHSR(2), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(2), GLRA3(1), GLRB(6), GPR156(2), GPR50(1), GPR63(3), GPR83(5), GRIA1(9), GRIA2(8), GRIA3(5), GRIA4(10), GRID1(7), GRID2(7), GRIK1(4), GRIK2(4), GRIK3(7), GRIK4(10), GRIK5(2), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRIN3A(3), GRIN3B(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM6(3), GRM7(3), GRM8(11), GRPR(1), GZMA(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HRH4(2), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LEPR(4), LHCGR(6), MAS1(1), MC1R(2), MC2R(1), MC3R(1), MC4R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPBWR1(6), NPBWR2(5), NPFFR1(1), NPFFR2(2), NPY1R(1), NPY2R(1), NPY5R(1), NR3C1(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(7), PRL(2), PRLHR(2), PRLR(3), PRSS1(3), PRSS3(1), PTGER2(1), PTGER3(1), PTGER4(3), PTGFR(1), PTGIR(2), PTH2R(2), RXFP1(5), RXFP2(6), SSTR1(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR2(1), TAAR5(2), TAAR6(1), TAAR8(1), TACR3(3), TBXA2R(2), THRA(6), THRB(1), TRPV1(3), TSHB(2), TSHR(3), TSPO(1) 59829595 539 172 538 178 139 175 80 58 87 0 0.0495 1.000 1.000 457 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), ARHGAP5(8), BCAR1(6), BIRC2(1), BIRC3(2), BRAF(4), CAPN2(1), CAV1(1), CCND1(1), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), CRK(1), CTNNB1(9), DIAPH1(2), DOCK1(9), EGF(4), EGFR(5), ELK1(2), ERBB2(12), FARP2(3), FLNA(3), FLNB(4), FLNC(10), FLT1(7), FN1(7), FYN(1), GSK3B(3), HGF(2), HRAS(1), IBSP(5), IGF1(1), IGF1R(4), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), JUN(1), KDR(5), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), MAP2K1(2), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MET(4), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARVA(2), PARVB(1), PARVG(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PGF(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(1), PRKCG(2), PTEN(7), PTK2(1), PXN(3), RAC1(1), RAF1(2), RAP1A(1), RAPGEF1(4), RELN(17), RHOA(3), ROCK1(2), ROCK2(4), SHC4(3), SOS1(3), SOS2(1), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TLN1(7), TLN2(11), TNC(8), TNN(7), TNR(10), TNXB(14), VAV1(8), VAV2(1), VAV3(2), VCL(8), VEGFC(5), VWF(9), ZYX(1) 103525747 700 171 682 180 186 242 85 64 122 1 6.88e-05 1.000 1.000 458 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY7(5), ADCY8(11), ADCY9(6), ADORA2A(5), ADORA2B(2), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ATP2A1(4), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), ATP2B4(7), AVPR1A(3), BST1(1), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), CCKAR(1), CCKBR(3), CD38(2), CHRM1(2), CHRM2(8), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), DRD1(3), EDNRA(1), EDNRB(3), EGFR(5), ERBB2(12), ERBB3(6), ERBB4(17), F2R(4), GNA14(1), GNA15(2), GNAL(2), GNAQ(1), GNAS(16), GRIN2A(3), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), GRPR(1), HRH1(2), HRH2(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), LHCGR(6), MYLK(6), MYLK2(1), NOS1(6), NOS3(5), NTSR1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), PDE1A(3), PDE1B(3), PDE1C(3), PDGFRA(4), PDGFRB(4), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), PTGER3(1), PTGFR(1), PTK2B(4), RYR1(13), RYR2(35), RYR3(28), SLC25A4(2), SLC25A5(2), SLC8A1(7), SLC8A2(4), SLC8A3(1), SPHK2(3), TACR3(3), TBXA2R(2), TNNC1(1), TRPC1(5), VDAC1(2), VDAC2(1) 76355780 580 162 571 171 158 210 69 53 90 0 0.00133 1.000 1.000 459 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ABI2(4), ACTN1(1), ACTN2(8), ACTN4(4), APC(15), ARAF(3), ARHGEF1(3), ARHGEF12(4), ARHGEF4(1), ARHGEF6(2), ARHGEF7(3), ARPC5(1), BAIAP2(2), BCAR1(6), BRAF(4), CD14(1), CFL1(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CRK(1), CSK(2), CYFIP1(5), CYFIP2(8), DIAPH1(2), DIAPH2(8), DIAPH3(6), DOCK1(9), EGF(4), EGFR(5), EZR(1), F2(4), F2R(4), FGD3(2), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FN1(7), GNA12(1), GNA13(3), GSN(3), HRAS(1), IQGAP1(7), IQGAP2(2), IQGAP3(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), KRAS(3), LIMK1(1), LIMK2(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MRAS(1), MSN(7), MYH10(9), MYH14(10), MYH9(2), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), NCKAP1(4), NCKAP1L(3), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PFN4(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R12B(1), PTK2(1), PXN(3), RAC1(1), RAF1(2), RDX(6), RHOA(3), ROCK1(2), ROCK2(4), SCIN(4), SLC9A1(2), SOS1(3), SOS2(1), SSH1(1), SSH2(7), SSH3(1), TIAM1(6), TIAM2(4), VAV1(8), VAV2(1), VAV3(2), VCL(8), WASF1(3), WASF2(3), WASL(2) 76890559 522 162 505 127 129 173 76 52 92 0 8.98e-05 1.000 1.000 460 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), COL11A1(20), COL11A2(8), COL17A1(3), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), DSC1(1), DSC2(1), DSC3(1), DSG1(7), DSG2(6), DSG3(4), DSG4(3), FN1(7), GJA1(1), GJA10(1), GJA5(3), GJA8(2), GJB4(1), GJB5(1), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(5), ITGA6(7), ITGB4(5), KRT1(5), KRT10(4), KRT12(5), KRT13(1), KRT14(1), KRT15(3), KRT17(1), KRT18(2), KRT19(1), KRT2(1), KRT20(2), KRT23(7), KRT24(4), KRT25(3), KRT27(3), KRT28(1), KRT3(1), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT38(2), KRT39(1), KRT5(1), KRT6A(5), KRT6B(4), KRT6C(2), KRT72(3), KRT73(3), KRT74(1), KRT76(1), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(2), KRT84(2), KRT85(2), KRT9(4), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), LMNA(2), LMNB1(1), LMNB2(5), NES(8), PRPH(2), RELN(17), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VIM(2), VWF(9) 69517679 475 155 471 137 136 158 54 55 72 0 0.0172 1.000 1.000 461 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ANXA6(1), ARRB1(5), ARRB2(1), ATP1A4(3), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1S(5), CACNB1(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(2), CASQ1(1), CASQ2(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), GJA1(1), GJA5(3), GJB4(1), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), ITPR1(6), ITPR2(8), ITPR3(2), KCNB1(1), KCNJ5(2), MIB1(1), NME7(3), PKIA(1), PLCB3(4), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SLC8A3(1), USP5(5), YWHAB(1), YWHAQ(1) 53423988 371 151 364 114 100 123 44 34 69 1 0.0235 1.000 1.000 462 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD36(2), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), DAG1(1), FN1(7), FNDC1(10), FNDC3A(4), GP5(1), GP6(1), HMMR(4), HSPG2(14), IBSP(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), RELN(17), SDC2(1), SDC3(1), SDC4(1), SV2A(2), SV2C(3), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VWF(9) 62721619 420 149 414 118 120 139 44 40 77 0 0.0180 1.000 1.000 463 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM1(1), ABLIM3(1), ARHGEF12(4), CFL1(1), CXCR4(1), DCC(17), DPYSL2(1), DPYSL5(2), EFNA1(1), EFNA4(1), EFNB2(2), EFNB3(2), EPHA2(6), EPHA3(8), EPHA4(4), EPHA5(8), EPHA6(6), EPHA7(7), EPHA8(6), EPHB1(8), EPHB2(4), EPHB3(1), EPHB4(3), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(1), KRAS(3), L1CAM(4), LIMK1(1), LIMK2(3), LRRC4C(8), MAPK1(1), MET(4), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLXNA1(6), PLXNA2(12), PLXNA3(2), PLXNB1(8), PLXNB2(13), PLXNB3(5), PLXNC1(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTK2(1), RAC1(1), RASA1(9), RGS3(5), RHOA(3), RHOD(1), ROBO1(8), ROBO2(9), ROBO3(4), ROCK1(2), ROCK2(4), SEMA3A(6), SEMA3C(1), SEMA3D(5), SEMA3E(3), SEMA3F(3), SEMA3G(3), SEMA4A(1), SEMA4B(2), SEMA4C(1), SEMA4D(3), SEMA4F(3), SEMA4G(2), SEMA5A(9), SEMA5B(5), SEMA6A(4), SEMA6B(2), SEMA6C(2), SEMA6D(9), SLIT1(6), SLIT2(11), SLIT3(10), SRGAP1(2), SRGAP3(4), UNC5A(2), UNC5B(3), UNC5C(8), UNC5D(10) 54004221 407 147 402 120 84 149 59 47 68 0 0.0646 1.000 1.000 464 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), AMOTL1(3), ASH1L(5), CASK(3), CGN(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(4), EPB41L3(10), EXOC4(4), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(6), JAM3(1), KRAS(3), LLGL1(4), LLGL2(3), MAGI1(4), MAGI2(8), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(5), MRAS(1), MYH1(11), MYH10(9), MYH11(5), MYH13(11), MYH14(10), MYH15(7), MYH2(10), MYH3(9), MYH4(7), MYH6(10), MYH7(12), MYH7B(7), MYH8(3), MYH9(2), MYL7(2), MYL9(1), NRAS(1), OCLN(2), PARD3(7), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PTEN(7), RAB3B(1), RHOA(3), SPTAN1(8), SYMPK(4), TJAP1(1), TJP1(6), TJP2(2), TJP3(2), VAPA(1), YES1(5), ZAK(4) 54075502 368 145 365 92 93 129 53 33 59 1 0.00250 1.000 1.000 465 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 252 ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CCL14(2), CCL16(2), CCL18(1), CCL20(2), CCL22(1), CCL28(2), CCL5(1), CCL7(1), CCL8(1), CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CD40LG(1), CLCF1(1), CNTF(1), CRLF2(1), CSF1(1), CSF1R(9), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), CX3CL1(1), CX3CR1(3), CXCL1(1), CXCL14(1), CXCL3(1), CXCL6(1), CXCR3(1), CXCR4(1), EDA2R(2), EDAR(1), EGF(4), EGFR(5), EPOR(2), FASLG(1), FLT1(7), FLT3(9), FLT3LG(1), FLT4(5), GDF5(2), GH1(1), GH2(2), GHR(2), HGF(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL15(1), IL15RA(1), IL17B(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(1), IL19(1), IL1B(3), IL1R1(1), IL1R2(2), IL1RAP(2), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), INHBA(6), INHBB(1), INHBC(1), INHBE(4), KDR(5), KIT(7), KITLG(2), LEPR(4), LIFR(3), MET(4), MPL(2), NGFR(2), OSMR(3), PDGFB(2), PDGFC(3), PDGFRA(4), PDGFRB(4), PF4(1), PF4V1(2), PLEKHO2(1), PRL(2), PRLR(3), RELT(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF12A(1), TNFRSF18(1), TNFRSF19(2), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFRSF4(1), TNFRSF8(5), TNFRSF9(1), TNFSF10(1), TNFSF12(2), TNFSF13B(1), TNFSF14(1), TNFSF4(1), TNFSF9(2), TPO(8), TSLP(1), VEGFC(5), XCL2(1), XCR1(2) 49147061 333 144 327 105 73 101 46 41 72 0 0.240 1.000 1.000 466 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(5), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADM(1), ARRB1(5), ARRB2(1), ATF4(2), ATP2A2(5), ATP2A3(3), CALM3(1), CAMK2A(3), CAMK2B(2), CNN1(1), CNN2(1), CORIN(2), CRHR1(2), DGKZ(2), FOS(1), GABPA(1), GBA2(1), GJA1(1), GNAQ(1), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), GSTO1(1), GUCA2B(2), GUCY1A3(3), IGFBP3(2), IGFBP4(1), IL1B(3), IL6(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), MIB1(1), MYL4(1), MYLK2(1), NFKB1(2), NOS1(6), NOS3(5), OXTR(1), PDE4B(3), PDE4D(6), PKIA(1), PLCB3(4), PLCG1(5), PLCG2(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RAMP1(1), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RLN1(1), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SP1(1), TNXB(14), USP5(5), YWHAB(1), YWHAQ(1) 48991189 318 143 315 87 81 112 37 31 56 1 0.00912 1.000 1.000 467 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(5), ACTN2(8), ACTN4(4), DMD(19), MYBPC1(4), MYBPC2(3), MYBPC3(6), MYH3(9), MYH6(10), MYH7(12), MYH8(3), MYL1(1), MYL3(2), MYL4(1), MYL9(1), MYOM1(7), NEB(18), TMOD1(1), TNNI3(1), TNNT2(3), TPM2(1), TPM4(1), TTN(159), VIM(2) 38550052 282 136 282 83 54 103 56 37 29 3 0.303 1.000 1.000 468 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(8), ACACB(9), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CALM3(1), CBL(6), CBLB(4), CBLC(3), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(1), FASN(7), FBP2(2), FLOT2(5), FOXO1(2), GCK(1), GSK3B(3), GYS1(2), GYS2(2), HRAS(1), IKBKB(2), INPP5D(4), INSR(9), IRS1(6), IRS2(3), IRS4(3), KRAS(3), LIPE(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(2), PDE3A(7), PDE3B(3), PFKL(1), PFKM(4), PFKP(2), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PKLR(3), PPARGC1A(5), PPP1CA(1), PPP1CB(1), PPP1R3A(8), PPP1R3D(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1B(2), PRKAR2B(3), PRKCI(1), PRKCZ(2), PTPN1(5), PTPRF(3), PYGB(3), PYGL(3), PYGM(4), RAF1(2), RAPGEF1(4), RHEB(1), SHC4(3), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(3), SOS2(1), SREBF1(3), TRIP10(7), TSC1(10), TSC2(7) 44440949 314 135 305 80 76 103 42 32 61 0 0.00426 1.000 1.000 469 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADSL(3), ADSSL1(1), AK5(3), AK7(2), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), ENTPD4(1), ENTPD5(3), ENTPD6(1), FHIT(3), GART(2), GDA(2), GMPR2(1), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NME6(1), NME7(3), NPR1(6), NPR2(4), NT5C1A(1), NT5C1B(2), NT5M(1), PAPSS2(3), PDE10A(6), PDE11A(5), PDE1A(3), PDE1C(3), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6H(2), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(4), PKLR(3), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), PRPS1(1), PRPS2(2), RFC5(1), RRM2B(1), XDH(9) 45240429 274 133 273 83 61 90 47 30 46 0 0.212 1.000 1.000 470 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(2), CADM1(2), CADM3(1), CD2(1), CD22(5), CD226(1), CD28(1), CD34(2), CD40LG(1), CD58(1), CD6(2), CD80(1), CD86(1), CDH1(1), CDH15(1), CDH2(7), CDH3(2), CDH4(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CNTN1(11), CNTN2(3), CNTNAP1(3), CNTNAP2(7), GLG1(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(1), ICAM3(2), ITGA4(5), ITGA6(7), ITGA8(10), ITGA9(2), ITGAL(6), ITGAM(3), ITGAV(5), ITGB1(1), ITGB7(1), JAM3(1), L1CAM(4), MADCAM1(2), MAG(3), MPZL1(3), NCAM1(4), NCAM2(12), NEGR1(5), NEO1(6), NFASC(6), NLGN1(10), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(8), NRXN2(7), NRXN3(8), OCLN(2), PDCD1(1), PDCD1LG2(2), PTPRC(9), PTPRF(3), PTPRM(9), PVR(2), PVRL1(5), PVRL3(6), SDC2(1), SDC3(1), SDC4(1), SELE(3), SELL(1), SELP(3), SELPLG(1), SIGLEC1(9), SPN(1), VCAM1(4), VCAN(14) 40423305 319 133 317 95 75 109 47 33 53 2 0.0584 1.000 1.000 471 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), ACVR1B(2), ACVR1C(2), BAIAP2(2), CDH1(1), CREBBP(13), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), EGFR(5), EP300(12), ERBB2(12), FARP2(3), FER(2), FGFR1(1), FYN(1), IGF1R(4), INSR(9), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MET(4), MLLT4(3), NLK(4), PARD3(7), PTPN1(5), PTPRB(2), PTPRF(3), PTPRJ(6), PTPRM(9), PVRL1(5), PVRL3(6), PVRL4(2), RAC1(1), RHOA(3), SMAD2(2), SMAD3(3), SMAD4(14), SNAI1(1), SNAI2(5), SORBS1(7), SSX2IP(2), TCF7L1(2), TGFBR1(2), TGFBR2(15), TJP1(6), VCL(8), WASF1(3), WASF2(3), WASF3(3), WASL(2), YES1(5) 33176931 287 133 277 61 70 93 28 27 69 0 0.000960 1.000 1.000 472 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CHML(5), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CMKLR1(5), CNR1(3), CNR2(1), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GPR17(1), GPR173(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(2), GPR4(1), GPR50(1), GPR63(3), GPR83(5), GPR85(2), GPR87(2), GRPR(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LHCGR(6), MAS1(1), MC1R(2), MC3R(1), MC4R(5), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPN3(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(2), OR7C1(1), OXTR(1), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY6(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), RGR(1), RHO(1), RRH(2), SSTR1(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2) 32033299 272 131 270 85 71 92 36 35 38 0 0.0270 1.000 1.000 473 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRB1(1), CSNK1D(1), DRD1(3), DRD2(4), EGF(4), EGFR(5), GJA1(1), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(16), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), HTR2A(4), HTR2C(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K5(2), MAP3K2(3), MAPK1(1), MAPK7(1), NPR1(6), NPR2(4), NRAS(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PRKACA(3), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), SOS1(3), SOS2(1), TJP1(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1) 36723608 248 130 245 70 73 81 39 27 28 0 0.0442 1.000 1.000 474 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(1), ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(4), CAV1(1), CDKN2A(19), CRK(1), CSE1L(4), DOCK1(9), EPHB2(4), FYN(1), GRB7(3), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), MAP2K4(3), MAP3K11(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MRAS(1), MYLK(6), MYLK2(1), P4HB(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CB(4), PKLR(3), PLCG1(5), PLCG2(3), PTEN(7), PTK2(1), RAF1(2), RALA(1), RHO(1), ROCK1(2), ROCK2(4), SOS1(3), SOS2(1), TERF2IP(1), TLN1(7), TLN2(11), ZYX(1) 33818214 244 130 234 54 45 91 26 31 50 1 0.00515 1.000 1.000 475 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CBL(6), CBLB(4), CBLC(3), CCND1(1), CLCF1(1), CNTF(1), CREBBP(13), CRLF2(1), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), EP300(12), EPOR(2), GH1(1), GH2(2), GHR(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), LIFR(3), MPL(2), OSMR(3), PIAS1(7), PIAS3(1), PIAS4(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRL(2), PRLR(3), PTPN11(2), SOCS3(1), SOCS4(2), SOCS5(4), SOS1(3), SOS2(1), SPRED1(2), SPRED2(1), SPRY4(2), STAM(2), STAM2(3), STAT1(3), STAT2(4), STAT3(2), STAT4(5), STAT5A(3), STAT5B(2), STAT6(3), TPO(8), TSLP(1), TYK2(3) 40181493 272 128 259 74 55 88 30 42 57 0 0.100 1.000 1.000 476 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(8), ACTN4(4), ARHGAP5(8), BCAR1(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), CXCR4(1), CYBA(1), CYBB(2), EZR(1), GNAI1(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), ITK(7), JAM3(1), MAPK11(1), MAPK14(1), MLLT4(3), MMP2(3), MMP9(3), MSN(7), MYL7(2), MYL9(1), NCF1(1), NCF4(2), NOX1(1), NOX3(5), OCLN(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAC1(1), RAP1A(1), RAPGEF3(1), RAPGEF4(7), RASSF5(2), RHOA(3), ROCK1(2), ROCK2(4), SIPA1(3), TXK(1), VAV1(8), VAV2(1), VAV3(2), VCAM1(4), VCL(8) 34440593 262 127 250 68 55 97 39 27 44 0 0.0159 1.000 1.000 477 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(4), CACNA1A(13), CRHR1(2), GNA12(1), GNA13(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GNAZ(2), GRIA1(9), GRIA2(8), GRIA3(5), GRID2(7), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), IGF1(1), IGF1R(4), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NOS1(6), NOS3(5), NPR1(6), NPR2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), RYR1(13) 30965346 222 125 219 54 56 75 34 21 36 0 0.00767 1.000 1.000 478 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(4), AKT3(2), BCAR1(6), CAPN1(1), CAPN11(4), CAPN2(1), CAPN3(3), CAPN5(2), CAPN6(6), CAPN7(1), CAPN9(2), CAPNS1(3), CAV1(1), CRK(1), CSK(2), DOCK1(9), FYN(1), GIT2(2), ILK(2), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), MAP2K1(2), MAP2K2(3), MAPK10(3), MAPK4(2), MAPK6(3), MAPK7(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PIK3R2(3), PTK2(1), PXN(3), RAC1(1), RAPGEF1(4), RHO(1), ROCK1(2), ROCK2(4), SDCCAG8(2), SORBS1(7), SOS1(3), TLN1(7), TNS1(7), VAV2(1), VAV3(2), VCL(8), ZYX(1) 37560037 225 123 222 64 56 74 27 23 45 0 0.0862 1.000 1.000 479 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ATF4(2), CACNA1C(14), CACNA1D(7), CACNA1F(7), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), EGFR(5), ELK1(2), GNAQ(1), GNAS(16), GNRH1(1), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK9(2), MMP14(4), MMP2(3), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLD1(4), PLD2(3), PRKACA(3), PRKCA(1), PRKCD(2), PTK2B(4), RAF1(2), SOS1(3), SOS2(1) 35964483 218 118 214 63 61 72 23 25 37 0 0.117 1.000 1.000 480 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG6(2), ALG9(1), B3GNT1(4), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), B4GALT7(3), C1GALT1(1), CHPF(4), CHST1(1), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST6(2), CHST7(1), CHSY1(3), DDOST(1), EXT1(4), EXT2(1), EXTL3(3), FUT11(1), FUT8(2), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GANAB(2), GCNT1(3), GCNT3(1), GCNT4(4), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), NDST1(5), NDST2(5), NDST3(5), NDST4(6), OGT(3), RPN1(3), RPN2(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(2), STT3B(5), WBSCR17(10), XYLT1(3), XYLT2(3) 30302191 204 116 204 66 53 64 33 25 29 0 0.328 1.000 1.000 481 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADSL(3), AK5(3), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), ATP1B1(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), FHIT(3), GART(2), GDA(2), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NPR1(6), NPR2(4), NT5M(1), PAPSS2(3), PDE1A(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6B(1), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(4), PKLR(3), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), PRPS1(1), PRPS2(2) 35433583 198 116 197 75 42 61 30 27 38 0 0.864 1.000 1.000 482 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM3(1), CDS1(1), CDS2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5D(4), INPP5E(3), INPPL1(2), ITPK1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), PI4KA(7), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3C3(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PRKCA(1), PRKCG(2), PTEN(7), PTPMT1(1), SYNJ1(7), SYNJ2(4) 34966886 216 115 208 53 43 84 18 27 42 2 0.0118 1.000 1.000 483 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1B(2), ACVR1C(2), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(2), BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CHRD(5), COMP(2), CREBBP(13), CUL1(4), DCN(6), E2F5(1), EP300(12), FST(1), GDF5(2), GDF6(1), GDF7(1), ID1(1), ID3(1), ID4(1), IFNG(1), INHBA(6), INHBB(1), INHBC(1), INHBE(4), LEFTY2(1), LTBP1(10), MAPK1(1), NODAL(1), NOG(1), PITX2(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), RBL1(2), RBL2(4), RHOA(3), ROCK1(2), ROCK2(4), SMAD2(2), SMAD3(3), SMAD4(14), SMAD6(1), SMAD9(2), SMURF1(2), SMURF2(2), SP1(1), TFDP1(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), THBS1(2), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(3), ZFYVE9(4) 27044229 199 114 194 46 39 69 30 19 42 0 0.0279 1.000 1.000 484 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(1), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CAMK2A(3), CAMK2B(2), CBL(6), CBLB(4), CBLC(3), CDKN1A(2), CRK(1), EGF(4), EGFR(5), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(6), ERBB4(17), GAB1(1), GSK3B(3), HRAS(1), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), NCK1(1), NCK2(2), NRAS(1), NRG1(8), NRG2(2), NRG3(8), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), RAF1(2), SHC4(3), SOS1(3), SOS2(1), STAT5A(3), STAT5B(2), TGFA(1) 28525797 219 113 206 41 48 85 30 23 33 0 9.85e-05 1.000 1.000 485 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), AKAP1(3), AKAP10(2), AKAP11(4), AKAP12(4), AKAP2(7), AKAP3(5), AKAP4(3), AKAP5(1), AKAP6(9), AKAP8(1), AKAP9(14), ARHGEF1(3), CALM3(1), CHMP1B(1), GNA12(1), GNA13(3), GNA14(1), GNA15(2), GNAI2(1), GNAI3(1), GNAL(2), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNGT1(1), HRAS(1), IL18BP(1), ITPR1(6), KRAS(3), NRAS(1), PALM2(3), PDE1A(3), PDE1B(3), PDE1C(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(1), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKD3(1), RHOA(3), SLC9A1(2), USP5(5) 31980176 217 112 213 55 57 64 32 27 37 0 0.0289 1.000 1.000 486 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), CALM3(1), CAMK2A(3), CAMK2B(2), CREB3L1(2), CREB3L2(1), CREB3L4(1), CREBBP(13), CTNNB1(9), DCT(4), DVL2(1), DVL3(2), EDNRB(3), EP300(12), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GSK3B(3), HRAS(1), KIT(7), KITLG(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MC1R(2), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), POMC(2), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), TCF7L1(2), TYR(3), TYRP1(1), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2) 29873284 209 112 207 61 70 60 33 16 30 0 0.0547 1.000 1.000 487 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(2), AMY2B(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENPP1(5), ENPP3(4), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), GAA(3), GANC(1), GBA(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), IFIH1(3), MGAM(9), MOV10L1(4), NUDT8(1), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SI(14), SKIV2L2(5), SMARCA2(8), SMARCA5(2), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UXS1(1) 34453355 180 110 179 55 25 66 27 27 35 0 0.492 1.000 1.000 488 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(8), ABCA12(14), ABCA13(19), ABCA2(7), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(9), ABCA7(5), ABCA8(3), ABCA9(3), ABCB1(7), ABCB10(2), ABCB11(6), ABCB4(4), ABCB5(3), ABCB6(6), ABCB7(1), ABCB8(1), ABCB9(1), ABCC1(3), ABCC10(1), ABCC11(8), ABCC12(5), ABCC2(6), ABCC3(2), ABCC4(6), ABCC5(7), ABCC8(6), ABCC9(12), ABCD2(3), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(6), ABCG4(1), ABCG5(1), ABCG8(3), CFTR(8), TAP2(1) 33068014 200 109 197 49 35 72 30 16 47 0 0.0125 1.000 1.000 489 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(3), BID(1), BRAF(4), CD244(3), CD48(1), FASLG(1), FCGR3A(1), FYN(1), HLA-A(1), HLA-B(7), HLA-C(4), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(1), ICAM2(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), ITGAL(6), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRD1(2), KLRK1(3), KRAS(3), LCK(1), LCP2(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MICA(2), MICB(1), NCR1(2), NCR2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NRAS(1), PAK1(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(4), PTPN11(2), RAC1(1), RAF1(2), SH2D1B(2), SHC4(3), SOS1(3), SOS2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), ULBP1(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3) 31362892 208 109 199 47 43 82 25 20 38 0 0.00350 1.000 1.000 490 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(4), AKT2(1), AKT3(2), BCL10(1), CARD11(5), CBL(6), CBLB(4), CBLC(3), CD28(1), CD3E(1), CD40LG(1), CHUK(5), FOS(1), FYN(1), GRAP2(4), HRAS(1), IFNG(1), IKBKB(2), IL10(2), ITK(7), JUN(1), KRAS(3), LCK(1), LCP2(4), MALT1(1), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDCD1(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCQ(4), PTPRC(9), RASGRP1(4), RHOA(3), SOS1(3), SOS2(1), TEC(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3) 28021921 203 108 193 42 38 75 32 23 35 0 0.00226 1.000 1.000 491 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(11), ARAF(3), ATF4(2), BRAF(4), CACNA1C(14), CALM3(1), CAMK2A(3), CAMK2B(2), CREBBP(13), EP300(12), GNAQ(1), GRIA1(9), GRIA2(8), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R1A(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4) 28095699 181 108 180 55 41 60 25 27 28 0 0.248 1.000 1.000 492 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(1), CD14(1), CD1A(5), CD1B(3), CD1C(4), CD1D(2), CD1E(6), CD2(1), CD22(5), CD33(2), CD34(2), CD36(2), CD38(2), CD3E(1), CD5(2), CD55(1), CD59(1), CD7(1), CD9(1), CR1(2), CR2(4), CSF1(1), CSF1R(9), CSF2RA(2), CSF3(2), CSF3R(5), DNTT(1), EPOR(2), FCER2(1), FLT3(9), FLT3LG(1), GP5(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(3), IL1R1(1), IL1R2(2), IL2RA(1), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL7R(3), IL9R(3), ITGA1(3), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGAM(3), ITGB3(2), KIT(7), KITLG(2), MME(4), TFRC(2), THPO(2), TPO(8) 22750395 169 102 167 46 29 57 22 23 37 1 0.155 1.000 1.000 493 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(2), ACVRL1(3), AKT1(4), AURKB(1), BMPR1A(1), BMPR2(3), BUB1(2), CDKL2(2), CDS1(1), CDS2(1), CLK1(2), CLK4(3), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MAP3K10(4), NEK1(3), NEK3(3), PAK4(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CA(21), PIK3CB(4), PIK3CG(1), PIM2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3), PLK3(1), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKG1(3), RAF1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(5), TGFBR1(2), VRK1(1) 31911414 189 101 179 45 43 76 20 17 33 0 0.0126 1.000 1.000 494 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(2), C3(9), C3AR1(3), C4BPA(1), C4BPB(1), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C8B(3), C9(2), CD46(5), CD55(1), CD59(1), CFH(10), CFI(1), CPB2(1), CR1(2), CR2(4), F10(2), F11(4), F12(2), F13A1(1), F13B(3), F2(4), F2R(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), KNG1(2), MASP1(4), MBL2(4), PLAT(1), PLG(3), PROC(1), PROS1(5), SERPINA1(2), SERPINA5(1), SERPINF2(2), SERPING1(2), TFPI(2), THBD(3), VWF(9) 24880504 157 98 155 34 34 53 15 21 34 0 0.0188 1.000 1.000 495 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(5), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(5), EED(2), EHMT1(6), EHMT2(4), EZH1(2), EZH2(1), FBXO11(3), HCFC1(4), HSF4(2), JMJD6(2), KDM6A(8), NSD1(14), OGT(3), PAXIP1(10), PPP1CA(1), PPP1CB(1), PRDM2(2), PRDM6(5), PRDM7(2), PRDM9(10), PRMT1(2), PRMT5(2), PRMT7(2), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(5), SETD1B(3), SETD2(7), SETD8(2), SETDB1(3), SETDB2(5), SETMAR(1), STK38(2), SUV420H1(5), SUV420H2(3), SUZ12(1), WHSC1(5), WHSC1L1(5) 34447065 154 96 150 31 34 49 13 21 36 1 0.0210 1.000 1.000 496 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(4), CEBPA(2), CHUK(5), DAXX(3), ELK1(2), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP3K9(2), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAP4K5(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK4(2), MAPK6(3), MAPK7(1), MAPK8(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), MKNK2(2), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(2), RIPK1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), SP1(1), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1) 27086930 149 94 148 41 37 45 17 21 29 0 0.221 1.000 1.000 497 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CD22(5), CD81(1), CR2(4), CSK(2), DAG1(1), FLOT2(5), GSK3A(2), GSK3B(3), INPP5D(4), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), MAPK1(1), NFATC1(4), NFATC2(6), NR0B2(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTPRC(9), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8) 20264444 141 93 132 34 31 53 13 17 26 1 0.0327 1.000 1.000 498 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5E(3), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKB(6), MIOX(2), PI4KA(7), PI4KB(1), PIK3C3(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PTEN(7), PTPMT1(1), SYNJ1(7), SYNJ2(4) 20624225 139 91 131 34 24 64 10 15 24 2 0.0286 1.000 1.000 499 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), APH1A(1), CREBBP(13), CTBP2(2), DLL1(1), DTX1(3), DTX2(3), DTX3L(2), DTX4(2), DVL2(1), DVL3(2), EP300(12), HDAC1(1), HES1(1), JAG1(2), JAG2(4), LFNG(2), MAML1(2), MAML2(6), MAML3(4), NCOR2(12), NCSTN(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(1), RBPJ(1), RBPJL(6), SNW1(1) 19872809 145 90 144 51 36 39 11 14 43 2 0.768 1.000 1.000 500 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(2), CCKBR(3), CCR2(1), CCR3(2), CCR5(1), CELSR1(8), CELSR2(10), CELSR3(7), CHRM2(8), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(2), EMR3(3), F2R(4), FSHR(6), GHRHR(2), GPR116(5), GPR132(1), GPR133(3), GPR17(1), GPR18(1), GPR55(1), GPR56(3), GPR84(3), GPR88(1), GRM1(9), GRPR(1), HRH4(2), LGR6(5), LPHN2(9), LPHN3(9), NTSR1(1), OR2M4(4), P2RY11(2), P2RY13(3), PTGFR(1), SMO(4), TAAR5(2), TSHR(3), VN1R1(3) 18000328 145 89 143 40 33 51 24 15 22 0 0.0714 1.000 1.000 501 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), CPEB1(1), EGFR(5), ERBB2(12), ERBB4(17), ETS1(1), ETV7(1), FMN2(20), KRAS(3), MAP2K1(2), MAPK1(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), PIWIL1(4), PIWIL2(3), PIWIL3(1), RAF1(2), SOS1(3), SOS2(1), SPIRE1(2), SPIRE2(3) 14758728 132 89 127 35 25 52 15 11 27 2 0.200 1.000 1.000 502 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(4), APOA1(1), CD36(2), CITED2(2), CPT1B(6), CREBBP(13), EHHADH(1), EP300(12), HSD17B4(4), JUN(1), LPL(2), MAPK1(1), ME1(1), MRPL11(1), NCOA1(7), NCOR1(4), NCOR2(12), NR0B2(1), NRIP1(3), PDGFA(2), PIK3CA(21), PIK3R1(5), PPARA(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RB1(8), SP1(1), STAT5A(3), STAT5B(2) 17374120 127 89 118 31 20 51 10 8 38 0 0.147 1.000 1.000 503 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(6), CD28(1), CSK(2), DAG1(1), DTYMK(2), EPHB2(4), FBXW7(14), GRAP2(4), ITK(7), ITPKB(6), LCK(1), LCP2(4), MAPK1(1), NCK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLCG1(5), PTPRC(9), RAF1(2), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), SOS1(3), SOS2(1), VAV1(8), ZAP70(3) 15742505 119 89 116 30 26 39 15 15 24 0 0.111 1.000 1.000 504 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), CABIN1(8), CALM3(1), CAMK2B(2), CD3E(1), CDKN1A(2), CNR1(3), CREBBP(13), CSNK2A1(1), EP300(12), FCGR3A(1), FOS(1), FOSL1(2), GATA3(4), GSK3A(2), GSK3B(3), HRAS(1), IFNB1(1), IFNG(1), IL10(2), IL1B(3), IL2RA(1), IL3(2), IL6(1), ITK(7), KPNA5(1), MAPK14(1), MAPK8(1), MAPK9(2), MEF2A(1), MEF2D(3), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB2(2), NUP214(2), OPRD1(1), P2RX7(2), PAK1(2), PPP3CB(2), PPP3CC(3), PTPRC(9), RPL13A(1), SLA(3), SP1(1), SP3(2), TRAF2(1), TRPV6(3), VAV1(8), VAV2(1), VAV3(2), XPO5(2) 25157462 155 86 154 34 34 55 21 10 35 0 0.0121 1.000 1.000 505 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(4), AKT2(1), AKT3(2), CASP8(6), CCL5(1), CD14(1), CD80(1), CD86(1), CHUK(5), FADD(1), FOS(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IKBKB(2), IKBKE(2), IL12B(1), IL1B(3), IL6(1), IRAK1(2), IRAK4(1), IRF5(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K7(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), RAC1(1), RIPK1(2), STAT1(3), TICAM1(1), TLR1(2), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TLR8(2), TOLLIP(1), TRAF3(1), TRAF6(1) 24297105 140 86 131 33 22 52 24 14 28 0 0.0401 1.000 1.000 506 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(4), AKT2(1), AKT3(2), BCL10(1), BLNK(3), BTK(1), CARD11(5), CD22(5), CD79A(2), CD81(1), CHUK(5), CR2(4), FCGR2B(1), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(4), JUN(1), KRAS(3), LILRB3(1), LYN(2), MALT1(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RASGRP3(2), SYK(2), VAV1(8), VAV2(1), VAV3(2) 20540872 149 86 139 34 27 57 21 12 31 1 0.0202 1.000 1.000 507 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(4), CLK3(1), CLK4(3), COL2A1(8), CPSF1(5), CPSF2(3), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(4), DDX20(1), DHX15(2), DHX16(1), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(3), GIPC1(5), LSM7(1), METTL3(2), NCBP1(1), NONO(1), PABPN1(1), PAPOLA(2), POLR2A(3), PRPF18(1), PRPF3(2), PRPF4(3), PRPF4B(2), PRPF8(5), PSKH1(1), PTBP1(3), RBM5(2), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(4), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(4), SF3B4(1), SNRPD2(1), SNRPF(1), SNRPN(4), SNURF(1), SPOP(2), SRPK1(3), SRPK2(2), SUPT5H(3), TXNL4A(1), U2AF2(1), XRN2(1) 29207358 136 83 136 35 30 49 14 13 30 0 0.264 1.000 1.000 508 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), ENTPD4(1), ENTPD5(3), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(2), NT5M(1), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), RFC5(1), RRM2B(1), TXNRD1(3), TXNRD2(2), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2), UPP2(1) 22592480 127 80 127 39 32 44 16 11 24 0 0.319 1.000 1.000 509 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(9), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADIPOR1(2), AKT1(4), AKT2(1), AKT3(2), CAMKK2(4), CD36(2), CHUK(5), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), IKBKB(2), IRS1(6), IRS2(3), IRS4(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PCK1(2), PCK2(2), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(4), PTPN11(2), SLC2A1(1), SOCS3(1), STAT3(2), STK11(5), TNFRSF1B(1), TRAF2(1), TYK2(3) 22938755 130 79 129 42 34 41 18 9 28 0 0.363 1.000 1.000 510 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(4), CALM3(1), CAV1(1), CHRM1(2), CHRNA1(4), FLT1(7), FLT4(5), KDR(5), NOS3(5), PDE2A(3), PDE3A(7), PDE3B(3), PRKAR1B(2), PRKAR2B(3), PRKG1(3), PRKG2(5), RYR2(35), SLC7A1(2), SYT1(3) 11455365 101 77 99 31 22 36 18 7 18 0 0.240 1.000 1.000 511 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(2), AMY2B(5), ENPP1(5), ENPP3(4), GAA(3), GANAB(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), MGAM(9), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RNPC3(4), SI(14), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UXS1(1) 15984577 96 76 95 30 14 39 21 10 12 0 0.479 1.000 1.000 512 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(1), ADCY8(11), CACNA1A(13), CACNA1B(6), GNAS(16), GRM4(7), ITPR3(2), KCNB1(1), PDE1A(3), PLCB2(1), PRKACA(3), SCNN1A(3), SCNN1B(1), SCNN1G(5), TAS1R1(2), TAS1R2(4), TAS1R3(2), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R39(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R46(3), TAS2R50(2), TAS2R60(3), TAS2R7(1), TAS2R8(1), TRPM5(1) 16025855 105 75 103 38 37 26 13 12 17 0 0.519 1.000 1.000 513 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), GSN(3), LMNA(2), LMNB1(1), LMNB2(5), MAP3K1(8), MAP3K5(8), MAPK8(1), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(14), PSEN1(2), PSEN2(1), PTK2(1), RASA1(9), RB1(8), RIPK1(2), SPTAN1(8), TNFRSF1B(1), TRAF1(2), TRAF2(1) 19209511 123 74 122 33 24 33 15 15 36 0 0.421 1.000 1.000 514 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(4), APC(15), AR(5), BRAF(4), CCL16(2), DAG1(1), EGFR(5), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(3), MAPK14(1), PHKA2(3), PIK3CA(21), PIK3CD(5), PIK3R1(5), PITX2(1), PTX3(1), RAF1(2) 14529520 109 74 100 36 16 39 16 16 22 0 0.580 1.000 1.000 515 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(1), AGT(1), AKT1(4), CALM3(1), CALR(2), CAMK1(1), CAMK1G(2), CREBBP(13), CSNK1A1(2), F2(4), GSK3B(3), HRAS(1), IGF1(1), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK8(1), MEF2C(2), MYH2(10), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKX2-5(3), PIK3CA(21), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), RAF1(2), SYT1(3) 13744056 114 73 106 31 27 35 14 9 29 0 0.157 1.000 1.000 516 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(15), AXIN1(2), CCND1(1), CSNK1E(1), CTNNB1(9), DVL2(1), DVL3(2), FBXW2(2), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LDLR(3), MAPK10(3), MAPK9(2), PAFAH1B1(1), PPP2R5C(4), PPP2R5E(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), RAC1(1), RHOA(3), SFRP4(3), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT5B(2), WNT7B(3) 16238863 117 73 115 32 31 30 23 7 25 1 0.195 1.000 1.000 517 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(2), ATP8A1(9), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CX3CR1(3), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(3), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GRPR(1), LHCGR(6), MC1R(2), MC2R(1), MC3R(1), MC4R(5), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), SSTR1(2), SSTR3(2), SSTR4(2), TAC4(1), TACR3(3), TSHR(3) 13766976 102 72 101 43 25 35 20 5 17 0 0.736 1.000 1.000 518 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(17), B3GALT4(1), CDR1(3), DGKI(11), IL6ST(5), MRPL19(3), PIGK(2), RPL10(1), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL23(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36(1), RPL38(1), RPL3L(1), RPL6(1), RPL7A(2), RPL8(2), RPLP0(1), RPLP1(1), RPS10(1), RPS11(2), RPS13(2), RPS14(2), RPS19(3), RPS24(1), RPS26(2), RPS5(2), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), RPS9(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1) 14646713 94 70 94 29 22 31 7 14 20 0 0.572 1.000 1.000 519 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(1), ALPP(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), FPGS(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SKIV2L2(5), SMARCA2(8), SMARCA5(2), SPR(1) 17413325 92 68 92 34 13 31 9 17 22 0 0.827 1.000 1.000 520 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), CARM1(2), DBH(1), DCT(4), DDC(2), ESCO1(3), ESCO2(1), FAH(2), HEMK1(1), HGD(2), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), MIF(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(2), TH(3), TPO(8), TYR(3), TYRP1(1) 16272572 79 66 79 29 25 26 3 7 18 0 0.592 1.000 1.000 521 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADH(1), HADHA(2), HSD17B4(4), HSD3B7(2), NSD1(14), OGDH(2), OGDHL(6), PIPOX(1), PLOD1(3), PLOD2(3), PLOD3(4), RDH13(1), SETD1A(5), SETDB1(3), SHMT1(2), SHMT2(2), TMLHE(1) 15831521 95 65 95 28 24 37 7 7 19 1 0.288 1.000 1.000 522 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT4(3), AGPAT6(1), CDS1(1), CDS2(1), CHAT(8), CHKB(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), ESCO1(3), ESCO2(1), ETNK1(2), ETNK2(2), GNPAT(1), GPAM(1), GPD2(2), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3), PTDSS1(2), SH3GLB1(2) 18177635 93 65 92 23 30 30 7 7 19 0 0.0792 1.000 1.000 523 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(5), ACOX1(4), ACOX2(2), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ANGPTL4(2), APOA1(1), APOA5(2), APOC3(3), AQP7(1), CD36(2), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A22(2), CYP8B1(1), EHHADH(1), FABP4(1), FABP6(1), FADS2(2), GK(1), GK2(4), HMGCS2(2), ILK(2), LPL(2), ME1(1), MMP1(1), PCK1(2), PCK2(2), PLTP(3), PPARA(1), PPARG(2), SCD(3), SCP2(1), SLC27A2(2), SLC27A4(1), SLC27A5(1), SLC27A6(6), SORBS1(7), UCP1(1) 17867386 97 65 95 27 26 37 6 5 23 0 0.160 1.000 1.000 524 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), AKT1(4), ANGPTL2(3), DAG1(1), DGKA(3), ETFA(1), ITGA9(2), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), MAP2K1(2), MAPK1(1), PAK1(2), PDE3A(7), PDE3B(3), PIK3C2G(4), PIK3CA(21), PIK3CD(5), PIK3R1(5), PSME1(1), SGCB(1) 13431115 89 64 81 26 12 32 12 15 18 0 0.338 1.000 1.000 525 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AGPAT6(1), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DAK(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), GK(1), GK2(4), GLB1(2), GPAM(1), LCT(8), LIPF(3), LIPG(1), LPL(2), MGLL(1), PNLIPRP1(2), PPAP2A(2), PPAP2B(3) 16301098 91 61 91 37 31 26 10 9 15 0 0.717 1.000 1.000 526 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(4), AKT2(1), AKT3(2), ARHGEF11(1), DLG4(4), GNA13(3), LPA(10), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK8(1), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RDX(6), ROCK1(2), ROCK2(4), SERPINA4(4), TBXA2R(2) 13762826 83 61 82 27 22 25 13 6 17 0 0.533 1.000 1.000 527 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), NT5M(1), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), TXNRD1(3), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2) 15903058 80 60 79 33 18 28 9 11 14 0 0.869 1.000 1.000 528 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(4), AKT2(1), AKT3(2), BRAF(4), DAG1(1), DRD2(4), EGFR(5), EPHB2(4), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PIK3CB(4), PITX2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), RAF1(2), RGS20(2), SOS1(3), SOS2(1), STAT3(2), TERF2IP(1) 16125997 80 60 80 29 15 33 4 14 14 0 0.624 1.000 1.000 529 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP6(1), CASP7(1), CASP8(6), CFLAR(2), DAXX(3), DFFA(1), DFFB(2), FADD(1), FAF1(3), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), PTPN13(7), RB1(8), RIPK2(1), SPTAN1(8) 11725820 85 59 84 25 11 17 7 18 32 0 0.795 1.000 1.000 530 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(2), ACTR3(1), AKT1(4), ANGPTL2(3), CFL1(1), FLNA(3), FLNC(10), FSCN1(1), FSCN2(2), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(10), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), RHO(1), ROCK1(2), ROCK2(4), WASF1(3), WASL(2) 13261959 79 59 79 25 18 19 16 12 14 0 0.436 1.000 1.000 531 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3) 13443830 76 58 76 25 23 26 6 6 15 0 0.394 1.000 1.000 532 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3) 13443830 76 58 76 25 23 26 6 6 15 0 0.394 1.000 1.000 533 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(8), ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6A(3), LDHAL6B(1), PDHA2(5), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PGM1(1), PKLR(3) 16081950 85 58 85 32 24 34 4 9 14 0 0.605 1.000 1.000 534 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(9), AR(5), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(2), NR1D2(3), NR1I2(2), NR2C2(4), NR2F2(1), NR2F6(1), NR3C1(1), NR4A1(1), NR4A2(3), NR5A2(6), PGR(5), PPARA(1), PPARG(2), RARB(1), RARG(1), ROR1(2), RORA(2), THRA(6), THRB(1), VDR(2) 11421800 76 58 76 25 21 28 8 9 9 1 0.373 1.000 1.000 535 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(4), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), COX5A(1), COX6B2(1), COX6C(1), COX7A1(1), COX8C(1), LHPP(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA4(1), NDUFA7(1), NDUFB10(1), NDUFB7(1), NDUFB8(2), NDUFC2(1), NDUFS1(1), NDUFS2(2), NDUFS3(1), NDUFS8(1), NDUFV2(1), NDUFV3(2), PPA1(1), PPA2(1), SDHA(4), SDHD(2), TCIRG1(1), UQCRC2(4), UQCRFS1(1), UQCRQ(1) 15541817 73 57 73 21 19 25 6 10 13 0 0.259 1.000 1.000 536 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(8), BCAR1(6), BCR(4), CAPN1(1), CAPNS1(3), CAPNS2(1), CAV1(1), CSK(2), FYN(1), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), PPP1R12B(1), PTK2(1), PXN(3), RAF1(2), RAP1A(1), ROCK1(2), SOS1(3), TLN1(7), VCL(8), ZYX(1) 13230562 71 57 69 25 26 28 5 7 5 0 0.378 1.000 1.000 537 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), GK(1), GLB1(2), LCT(8), LIPF(3), LIPG(1), LPL(2), PNLIPRP1(2), PPAP2A(2), PPAP2B(3) 13430978 79 56 79 28 28 23 10 5 13 0 0.454 1.000 1.000 538 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(6), CARS(5), CARS2(2), DARS2(2), EARS2(1), EPRS(3), FARSA(2), FARSB(1), GARS(3), HARS(1), HARS2(1), IARS(4), IARS2(1), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), MTFMT(1), NARS2(1), QARS(3), RARS(4), RARS2(1), SARS(2), SARS2(1), TARS(6), TARS2(2), VARS(2), VARS2(2), WARS(1), WARS2(2), YARS(1), YARS2(2) 14795164 78 55 78 20 22 27 11 8 10 0 0.167 1.000 1.000 539 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(2), GNAS(16), GNGT1(1), HRAS(1), IGF1R(4), ITGB1(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(4), PPP2CA(1), PTPRR(6), RAF1(2), RPS6KA1(1), RPS6KA5(4), SOS1(3), STAT3(2) 9301134 65 54 65 24 21 20 9 7 8 0 0.672 1.000 1.000 540 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(4), APC(15), DAG1(1), DLG4(4), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(1), PTX3(1), RAC1(1), RHO(1), RYR1(13) 12596477 69 54 68 20 12 22 10 9 16 0 0.358 1.000 1.000 541 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), DBH(1), DCT(4), DDC(2), FAH(2), HGD(2), MAOA(2), MAOB(3), TAT(2), TH(3), TPO(8), TYR(3) 8813162 59 53 59 24 22 16 3 6 12 0 0.662 1.000 1.000 542 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(1), ARG2(1), ASL(3), ASS1(1), CKB(2), CKM(1), CPS1(11), DAO(1), EPRS(3), GAMT(1), GATM(2), GLUD1(1), GLUD2(4), LAP3(1), NOS1(6), NOS3(5), OAT(3), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), PYCR2(1), PYCRL(1), RARS(4), RARS2(1) 10098952 64 52 64 19 17 23 8 5 11 0 0.313 1.000 1.000 543 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(2), CHUK(5), DAXX(3), EGF(4), EGFR(5), ETS1(1), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK14(1), MAPK8(1), NFKB1(2), PPP2CA(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), RAF1(2), RIPK1(2), SP1(1), TNFRSF1B(1), TRAF2(1) 13434688 72 52 71 23 20 21 13 7 11 0 0.460 1.000 1.000 544 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(2), BCL2A1(1), BCL2L1(1), BCL2L2(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CD40LG(1), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), FASLG(1), IKBKE(2), MCL1(1), NFKB1(2), NGFR(2), NR3C1(1), NTRK1(5), PTPN13(7), RIPK1(2), TFG(2), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1), TRAF6(1) 12028345 64 50 64 19 18 17 9 8 12 0 0.347 1.000 1.000 545 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C2(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(3), CYP1A2(1), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2F1(4), CYP2S1(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), EPHX1(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), MGST3(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1) 15887502 69 50 69 19 16 26 6 10 11 0 0.249 1.000 1.000 546 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(2), CALM3(1), CAMK2A(3), CAMK2B(2), F2(4), FYN(1), GNAI1(1), GNGT1(1), HRAS(1), JAK2(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK14(1), MAPK8(1), MAPT(1), MYLK(6), PLCG1(5), PRKCA(1), PTK2B(4), RAF1(2), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), SYT1(3) 11643217 60 49 60 20 17 21 9 3 10 0 0.476 1.000 1.000 547 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM3(1), CAMK1(1), CAMK1G(2), ELK1(2), FPR1(1), GNA15(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NCF1(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PAK1(2), PIK3C2G(4), PLCB1(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RAF1(2), SYT1(3) 10677336 66 49 66 21 18 19 7 8 14 0 0.420 1.000 1.000 548 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), CALM3(1), EGFR(5), ELK1(2), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), MEF2A(1), MEF2C(2), MEF2D(3), PAK1(2), PRKCA(1), PTK2(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3) 9489899 53 47 53 19 13 18 5 6 11 0 0.649 1.000 1.000 549 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(1), B4GALT6(3), CERK(4), DEGS1(1), DEGS2(1), ENPP7(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SGMS1(1), SMPD1(2), SMPD3(1), SMPD4(1), SPHK2(3), SPTLC1(1), SPTLC2(4), UGCG(1), UGT8(1) 9843835 54 47 54 20 11 20 6 4 13 0 0.579 1.000 1.000 550 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AMDHD1(3), AOC2(4), AOC3(5), ASPA(2), CARM1(2), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(2), HEMK1(1), HNMT(1), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(3) 10969610 60 46 60 20 18 19 3 10 10 0 0.469 1.000 1.000 551 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(8), ARHGAP6(2), ARHGEF1(3), ARHGEF11(1), ARHGEF5(1), BAIAP2(2), CFL1(1), DIAPH1(2), GSN(3), LIMK1(1), MYLK(6), OPHN1(1), PIP5K1A(1), PPP1R12B(1), ROCK1(2), TLN1(7), VCL(8) 12589405 51 46 49 21 10 19 11 4 7 0 0.781 1.000 1.000 552 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(3), ELK1(2), HRAS(1), HSPB2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), PLA2G4A(1), RAC1(1), RIPK1(2), RPS6KA5(4), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1) 10317674 60 44 59 18 17 16 6 9 12 0 0.457 1.000 1.000 553 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(2), POLB(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLH(2), POLI(1), POLM(1), POLQ(9), PRIM1(4), PRIM2(3), REV1(4), REV3L(11), RFC5(1) 11320976 57 43 57 23 8 23 8 10 8 0 0.900 1.000 1.000 554 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(3), AKT1(4), AKT2(1), AKT3(2), DAG1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PITX2(1), PLD1(4), PLD2(3), PLD3(1), VN1R1(3) 12621471 57 43 56 25 11 20 4 7 15 0 0.895 1.000 1.000 555 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(4), BLNK(3), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK1(1), MAPK8IP3(4), PAPPA(6), RAC1(1), RPS6KA1(1), SOS1(3), SYK(2), VAV1(8), VAV2(1), VAV3(2) 8939971 53 42 53 17 10 13 8 9 13 0 0.632 1.000 1.000 556 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), BTG1(1), CBX3(1), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(4), EIF4G2(1), GFRA1(3), GSTM3(1), GSTP1(1), HERPUD1(1), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(2), NR1D2(3), PER1(5), PER2(5), PURA(1), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), VAPA(1), ZFR(2) 10038928 54 41 54 19 9 19 7 4 15 0 0.759 1.000 1.000 557 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), DFFA(1), DFFB(2), FADD(1), GAS2(2), LMNA(2), NFKB1(2), RIPK1(2), SPTAN1(8), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(4), TNFSF10(1), TNFSF12(2), TRAF2(1) 9209228 53 41 53 18 11 16 6 9 11 0 0.719 1.000 1.000 558 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), ALDOC(4), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6B(1), MDH1(2), MDH2(2), PC(1), PCK1(2), PDHA2(5), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PKLR(3), TNFAIP1(1) 11691304 53 41 53 18 13 21 6 3 10 0 0.448 1.000 1.000 559 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM3(1), CHUK(5), GNAQ(1), MAP3K1(8), NFATC1(4), NFATC2(6), NFKB1(2), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), SYT1(3), VIP(2) 7453006 48 40 48 19 11 13 6 3 15 0 0.848 1.000 1.000 560 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), ARSD(1), CARM1(2), CYP11B1(2), CYP11B2(4), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD11B2(1), HSD17B1(1), HSD3B1(2), HSD3B2(3), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1) 13674297 48 39 48 21 9 23 4 4 8 0 0.873 1.000 1.000 561 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(15), CERK(4), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKB(6), JUN(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2) 7555571 50 39 49 18 9 15 7 3 16 0 0.820 1.000 1.000 562 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), FUK(5), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), HSD3B7(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), PFKFB1(2), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1), RDH13(1), TSTA3(2) 10507009 54 38 53 20 12 24 3 5 10 0 0.512 1.000 1.000 563 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(5), HRAS(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(6), PRKAR1B(2), PRKAR2B(3), PTK2(1), PXN(3), TLN1(7) 9090625 45 38 45 24 12 20 6 2 5 0 0.921 1.000 1.000 564 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(1), GTF2F1(5), HDAC3(3), NCOA1(7), NCOA2(6), NCOA3(3), NCOR2(12), POLR2A(3), TBP(2) 6960463 43 38 43 16 7 19 3 4 10 0 0.696 1.000 1.000 565 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), CFL1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), LIMK1(1), MAP2K1(2), MAPK1(1), NOX1(1), PIK3C2G(4), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2(1), RAF1(2), ROCK2(4) 7040132 43 37 43 13 15 15 5 3 5 0 0.425 1.000 1.000 566 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(3), B4GALT2(1), FBP2(2), GAA(3), GALE(1), GANAB(2), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), LCT(8), MGAM(9), PFKM(4), PFKP(2), PGM1(1) 9016164 45 37 45 16 11 17 6 2 9 0 0.593 1.000 1.000 567 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(2), C6(6), C7(4), ICAM1(1), IL6(1), ITGA4(5), ITGAL(6), ITGB1(1), SELP(3), SELPLG(1), VCAM1(4) 6813809 43 37 43 16 4 20 3 7 9 0 0.710 1.000 1.000 568 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(2), DAG1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFAT5(4), PDE6A(2), PDE6B(1), PDE6C(3), PDE6H(2), SLC6A13(5), TF(4) 9860333 49 37 49 19 8 24 4 6 7 0 0.644 1.000 1.000 569 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(8), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(3), ITGB1(1), ITGB3(2), PTK2(1), PXN(3), RAC1(1), SPTAN1(8), TLN1(7) 7899281 41 37 41 17 14 17 0 5 5 0 0.657 1.000 1.000 570 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), ATP7B(4), COX5A(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRFS1(1) 10502103 42 36 42 12 12 12 5 6 7 0 0.314 1.000 1.000 571 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSD(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SMPD1(2), SPTLC1(1), SPTLC2(4), UGCG(1) 6588452 39 35 39 16 9 14 6 2 8 0 0.715 1.000 1.000 572 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(3), B4GALT2(1), GAA(3), GALE(1), GANC(1), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), HSD3B7(2), LCT(8), MGAM(9), PFKL(1), PFKM(4), PFKP(2), PGM1(1), RDH13(1) 10750438 46 35 46 17 13 15 6 3 9 0 0.623 1.000 1.000 573 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(5), IFNB1(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK1(2), IRAK3(1), JUN(1), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), TGFB2(1), TGFB3(2), TOLLIP(1), TRAF6(1) 8225044 40 35 39 16 8 11 4 6 11 0 0.860 1.000 1.000 574 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(5), CCNB1(1), GNAI1(1), GNAS(16), GNGT1(1), HRAS(1), MAPK1(1), MYT1(4), PRKAR1B(2), PRKAR2B(3), RPS6KA1(1) 5623036 37 33 37 18 13 10 4 3 7 0 0.900 1.000 1.000 575 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(1), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGW(1), PIGZ(1) 6769771 33 32 33 13 4 14 4 6 5 0 0.732 1.000 1.000 576 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(4), ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), HSD3B7(2), RDH13(1), SLC27A5(1), SOAT1(1), SOAT2(1) 8820515 40 31 40 20 12 12 5 4 7 0 0.912 1.000 1.000 577 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(4), F2RL3(2), GNAI1(1), GNGT1(1), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), PTK2(1), RAF1(2), SYK(2), TBXAS1(2) 6688883 34 31 34 14 11 13 3 2 5 0 0.709 1.000 1.000 578 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(2), CASP8(6), FADD(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFKB1(2), NSMAF(4), RAF1(2), RIPK1(2), SMPD1(2), TRAF2(1) 5541878 37 30 37 13 10 12 5 4 6 0 0.619 1.000 1.000 579 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM3(1), DLG4(4), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), NOS1(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), SYT1(3) 6975540 39 30 39 21 9 15 5 3 7 0 0.937 1.000 1.000 580 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(4), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3B(5), POLR3D(2), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(2) 9508564 37 30 37 17 9 8 6 4 10 0 0.934 1.000 1.000 581 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(8), DBH(1), DDC(2), GAD1(3), GAD2(2), HDC(2), MAOA(2), PAH(4), SLC18A3(1), TH(3), TPH1(2) 4008353 33 29 33 14 13 11 2 3 4 0 0.662 1.000 1.000 582 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(3), ACE2(3), AGT(1), AGTR2(2), ANPEP(1), CMA1(1), CPA3(2), ENPEP(4), LNPEP(3), MAS1(1), MME(4), NLN(3), REN(2), THOP1(1) 5721276 31 29 31 13 4 15 2 3 7 0 0.781 1.000 1.000 583 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(4), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TRAF3(1) 8166774 33 29 32 17 10 9 3 6 5 0 0.935 1.000 1.000 584 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(3), B3GAT2(2), B4GALT7(3), CHPF(4), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST7(1), CHSY1(3), DSE(3), XYLT1(3), XYLT2(3) 3879819 30 28 30 15 15 7 0 5 3 0 0.878 1.000 1.000 585 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(8), ARHGEF1(3), GNA12(1), GNA13(3), GNAQ(1), GNGT1(1), MYLK(6), PLCB1(3), PPP1R12B(1), PRKCA(1), ROCK1(2) 5736940 30 28 30 14 3 11 10 3 3 0 0.898 1.000 1.000 586 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT2(2), GALNT3(2), GALNT7(2), GALNT8(5), GALNT9(3), GCNT1(3), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), WBSCR17(10) 4052521 34 28 34 12 8 8 10 6 2 0 0.696 1.000 1.000 587 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), ARSB(2), ARSD(1), CYP11B1(2), CYP11B2(4), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1) 7425573 31 27 31 12 8 12 4 4 3 0 0.685 1.000 1.000 588 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CYP2C9(4), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), HADHA(2), SH3GLB1(2), YOD1(1) 8237049 31 27 31 10 8 12 2 2 7 0 0.645 1.000 1.000 589 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), APOA1(1), APOA4(1), APOC2(1), APOC3(3), APOE(1), HMGCR(1), LCAT(1), LDLR(3), LPL(2), LRP1(8), SCARB1(3), SOAT1(1) 7492972 33 27 33 10 10 13 2 2 6 0 0.288 1.000 1.000 590 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), CSNK1D(1), DRD1(3), DRD2(4), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKAR1B(2), PRKAR2B(3) 4290671 29 26 29 11 7 12 2 3 5 0 0.597 1.000 1.000 591 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), NAGLU(3), SPAM1(1) 5761800 30 26 30 11 6 11 4 4 5 0 0.642 1.000 1.000 592 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(2), ENPP1(5), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5M(1) 3981039 26 26 26 10 0 15 0 5 6 0 0.802 1.000 1.000 593 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(3), ITGB1(1), L1CAM(4), LYN(2), SELP(3) 4270739 27 24 27 15 5 13 4 2 3 0 0.918 1.000 1.000 594 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPOR(2), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAPK8(1), PLCG1(5), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2) 6091421 28 24 28 10 9 10 2 3 4 0 0.619 1.000 1.000 595 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(9), FASN(7), OXSM(1) 4516159 25 23 25 14 6 8 3 3 5 0 0.914 1.000 1.000 596 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(2), LEPR(4), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1) 3968022 23 23 23 10 3 12 4 2 2 0 0.845 1.000 1.000 597 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTR(7) 4851690 26 23 26 10 7 10 1 5 3 0 0.665 1.000 1.000 598 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4) 4509704 26 23 26 10 3 15 5 0 3 0 0.685 1.000 1.000 599 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(2), IARS(4), IARS2(1), ILVBL(1), LARS(4), LARS2(2), PDHA2(5), VARS(2), VARS2(2) 5058240 23 22 23 10 6 7 4 3 3 0 0.802 1.000 1.000 600 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(3), GLB1(2), LCT(8), SLC33A1(2), ST3GAL1(2), ST3GAL2(2), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1) 4385856 25 22 25 10 7 7 6 3 2 0 0.729 1.000 1.000 601 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), SELE(3), SELL(1), SELP(3) 4488002 23 22 22 13 3 11 2 2 5 0 0.933 1.000 1.000 602 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CD28(1), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL4R(3), TGFB2(1), TGFB3(2) 5483732 27 22 26 12 6 8 3 7 3 0 0.821 1.000 1.000 603 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD1(5), PSMD11(1), PSMD12(2), PSMD2(2), PSMD6(1) 4416957 23 21 23 10 4 10 4 2 3 0 0.840 1.000 1.000 604 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(1), HRAS(1), IL3(2), IL3RA(1), JAK2(2), MAP2K1(2), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2) 4957079 25 21 25 10 8 7 2 4 4 0 0.674 1.000 1.000 605 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9) 4567107 24 20 24 14 3 7 2 6 6 0 0.980 1.000 1.000 606 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2) 6622347 21 19 21 10 6 7 2 1 5 0 0.890 1.000 1.000 607 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(8), PCYT1A(2), PDHA2(5), SLC18A3(1) 1894261 19 18 19 13 7 7 3 0 2 0 0.956 1.000 1.000 608 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 3623754 20 17 20 11 9 6 0 2 3 0 0.901 1.000 1.000 609 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), TBXA2R(2) 3017117 18 17 18 10 4 5 2 4 3 0 0.835 1.000 1.000 610 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(5), ITGAL(6), ITGB1(1), SELE(3), SELL(1) 3397097 17 16 16 11 2 8 2 2 3 0 0.958 1.000 1.000 611 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(1), ALPP(5), FPGS(1), SPR(1) 1878234 8 8 8 10 2 3 0 1 2 0 0.993 1.000 1.000 612 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST12(1), CHST13(1), PAPSS2(3), SULT1A1(1), SULT2B1(1), SUOX(1) 2550304 8 8 8 11 3 3 2 0 0 0 0.999 1.000 1.000 613 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(3), SUOX(1) 1626586 4 4 4 5 0 2 2 0 0 0 0.990 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 456615 2 2 2 2 2 0 0 0 0 0 0.921 1.000 1.000 615 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 1385008 2 2 2 3 1 1 0 0 0 0 0.958 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 139243 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000