rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(6), FMOD(2), KERA(2), LUM(3) 981573 14 14 14 0 2 6 2 3 1 0 0.0195 0.00162 0.998 2 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(15), AXIN1(2), BTRC(3), CTNNB1(9), DLL1(1), FZD1(4), GSK3B(3), NOTCH1(20), PSEN1(2), WNT1(1) 5943593 63 50 62 6 10 10 12 7 21 3 0.0104 0.00432 1.000 3 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(1), FURIN(2), NOTCH1(20), PSEN1(2) 2782582 28 25 28 2 5 2 3 5 11 2 0.0664 0.00688 1.000 4 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 5 ADAM17(3), NRG2(2), NRG3(8), PRKCA(1), PSEN1(2) 1787004 16 16 16 1 4 3 4 2 3 0 0.0478 0.0223 1.000 5 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), PRKCE(2) 1945815 24 21 24 3 7 5 9 0 3 0 0.0456 0.0666 1.000 6 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(11), GLS(2), GLUD1(1) 2139811 18 16 18 1 2 8 5 2 1 0 0.0318 0.0888 1.000 7 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(2), CDK2(1), CUL1(4), E2F1(2), RB1(8), TFDP1(1) 1884442 18 17 18 3 0 5 1 1 11 0 0.410 0.112 1.000 8 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADS(2), ACAT1(3), ECHS1(1), HADHA(2) 1517471 13 12 13 0 2 6 1 0 4 0 0.0680 0.116 1.000 9 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4), SNAP25(1), STX1A(2) 881127 9 8 8 0 6 1 1 1 0 0 0.0557 0.117 1.000 10 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(5), IFNG(1), IL12B(1) 817967 7 7 7 1 0 4 2 0 1 0 0.356 0.125 1.000 11 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(4), AOC3(5), CES1(5) 1669838 14 13 14 2 6 2 1 2 3 0 0.125 0.159 1.000 12 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(15), AXIN1(2), CREBBP(13), CTNNB1(9), EP300(12), FZD1(4), GSK3B(3), HDAC1(1), LDB1(1), PITX2(1), TRRAP(15), WNT1(1) 8831400 77 57 76 8 12 22 13 6 23 1 0.00167 0.176 1.000 13 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(4), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1) 2127906 19 19 19 2 5 7 4 2 1 0 0.0616 0.182 1.000 14 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(3), ESR1(6), GREB1(9), HSPB2(1), MTA1(3), MTA3(2), PDZK1(1), TUBA8(5) 3143384 30 26 30 3 8 8 5 5 4 0 0.00955 0.226 1.000 15 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(3) 1046227 7 7 7 0 2 1 2 0 2 0 0.125 0.238 1.000 16 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(4), PIK3R1(5), PLCB1(3), PLCG1(5), PRKCA(1), VAV1(8) 2957425 26 23 26 3 6 8 2 1 9 0 0.0598 0.242 1.000 17 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP54(5), SRP68(2), SRP72(2), SRPR(2) 2062185 13 13 13 1 1 4 3 3 2 0 0.205 0.245 1.000 18 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(2), CDK2(1), CUL1(4), E2F1(2), RB1(8), TFDP1(1) 2420467 21 20 21 4 1 5 2 2 11 0 0.404 0.246 1.000 19 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(1), CUL1(4), E2F1(2), NEDD8(2), RB1(8), TFDP1(1), UBE2M(1) 2384711 21 19 21 4 0 6 2 2 11 0 0.428 0.252 1.000 20 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 11 DNM1(4), GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GPHN(3), UBQLN1(1) 3104831 30 26 30 4 10 6 9 1 4 0 0.0375 0.256 1.000 21 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(12), LPL(2), NCOA1(7), NCOA2(6), PPARG(2) 4973922 42 34 42 4 7 15 3 3 14 0 0.0122 0.263 1.000 22 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(22), CDC25A(3), CDC25B(2), CHEK1(1), MYT1(4), WEE1(1) 3766467 33 28 33 4 5 15 4 3 6 0 0.0353 0.281 1.000 23 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(8) 1025905 8 7 8 0 0 3 2 3 0 0 0.137 0.283 1.000 24 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(6), CFL1(1), CFLAR(2) 1010390 9 7 9 1 0 4 1 2 2 0 0.372 0.287 1.000 25 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(8), BCAR1(6), CSK(2), CTNNA1(7), CTNNA2(8), CTNNB1(9), PTK2(1), PXN(3), VCL(8) 5416110 53 46 51 7 17 16 6 6 8 0 0.00242 0.298 1.000 26 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), HGD(2) 616902 4 4 4 0 1 1 0 0 2 0 0.469 0.300 1.000 27 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(22), ATR(5), CHEK1(1), CHEK2(3) 4111688 31 27 31 3 4 9 5 6 7 0 0.0558 0.307 1.000 28 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(8), CASP1(5), CASP8(6), CASP9(1), JUN(1), PRF1(4) 3494274 28 24 28 4 3 12 8 1 4 0 0.121 0.317 1.000 29 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(4) 557991 4 4 4 0 0 2 1 1 0 0 0.340 0.322 1.000 30 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(2) 475782 4 4 4 1 0 2 1 1 0 0 0.616 0.326 1.000 31 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS2(2), CPO(4), FECH(1), GATA1(1), HBA2(1), HBB(2), HMBS(1), UROD(1), UROS(1) 2228973 15 15 15 2 3 6 4 0 2 0 0.133 0.355 1.000 32 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(2), CASP1(5), CASP7(1), CASP8(6), GAPDH(2), INSR(9), ITCH(3), MAGI1(4), MAGI2(8), RERE(7), WWP1(6), WWP2(3) 6362409 60 47 60 6 12 18 9 10 11 0 0.00241 0.383 1.000 33 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(22), CDC25A(3), CDC25B(2), CDK2(1), CHEK1(1), MYT1(4), RB1(8), WEE1(1) 4595914 42 34 42 5 5 16 4 3 14 0 0.0349 0.384 1.000 34 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(2), ALDOC(4) 1053617 8 8 8 2 2 3 2 1 0 0 0.501 0.394 1.000 35 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), PPOX(4), UROD(1), UROS(1) 2036423 12 12 12 0 3 3 1 1 4 0 0.0382 0.408 1.000 36 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), TGDS(2), UGDH(3), UXS1(1) 1102634 7 7 7 1 1 2 1 1 2 0 0.524 0.409 1.000 37 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(22), BAX(2), CCND1(1), CCNE1(2), CDK2(1), CDKN1A(2), E2F1(2), MDM2(2), RB1(8), TIMP3(2) 4770256 47 40 47 8 5 14 6 5 17 0 0.128 0.417 1.000 38 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), IL2RG(3), IL4R(3), IRS1(6), JAK1(3), JAK3(6), STAT6(3) 4092468 28 24 28 2 5 4 6 7 6 0 0.0309 0.442 1.000 39 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(14), GNA12(1), PRKAG1(1), PRKAR2B(3) 2698874 19 17 19 2 1 11 1 4 2 0 0.113 0.449 1.000 40 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 JAK1(3), JAK2(2), JAK3(6), PIAS3(1), PTPRU(7), REG1A(1), SOAT1(1) 3500014 21 21 21 2 7 2 4 3 5 0 0.0524 0.470 1.000 41 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 2130519 18 17 18 3 7 4 2 1 4 0 0.168 0.483 1.000 42 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 2130519 18 17 18 3 7 4 2 1 4 0 0.168 0.483 1.000 43 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 1349243 8 8 8 1 3 5 0 0 0 0 0.208 0.484 1.000 44 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 195128 1 1 1 0 1 0 0 0 0 0 0.721 0.490 1.000 45 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), COPS5(3), EP300(12), HIF1A(5), JUN(1), NOS3(5), P4HB(2) 4694880 29 28 29 2 2 16 3 2 6 0 0.0256 0.498 1.000 46 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(1), RB1(8), SP1(1), SP3(2) 1793973 15 13 15 6 0 4 0 2 9 0 0.962 0.502 1.000 47 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 445864 2 2 2 0 1 0 1 0 0 0 0.517 0.507 1.000 48 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(2), HLA-DRB1(1), IL3(2) 836730 6 5 6 1 2 1 0 0 3 0 0.482 0.517 1.000 49 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(3), PTPRU(7), REG1A(1), STAT1(3), STAT2(4), TYK2(3) 3478016 23 20 23 1 8 6 2 3 4 0 0.00470 0.524 1.000 50 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CSF1(1), IL6(1), LDLR(3), LPL(2) 1449176 10 9 10 1 1 3 1 0 5 0 0.205 0.524 1.000 51 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(16), GNGT1(1), PRKACA(3) 1804529 25 25 25 5 10 6 2 2 5 0 0.271 0.525 1.000 52 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(7), AKT1(4), ATM(22), BAX(2), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(2), NQO1(1) 5486230 53 45 52 8 7 24 8 6 8 0 0.0269 0.526 1.000 53 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(1), BDH1(1), BDH2(4), HMGCS2(2), OXCT2(1) 1974087 12 11 12 1 0 7 1 1 3 0 0.228 0.536 1.000 54 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(13), DAXX(3), HRAS(1), PML(4), RB1(8), SIRT1(5), SP100(7), TNFRSF1B(1) 4929346 42 30 42 5 6 9 5 4 18 0 0.0277 0.550 1.000 55 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(8), GNAS(16), PRKAR1B(2), PRKAR2B(3), SLC9A3R1(3) 3580931 38 35 38 7 11 11 2 6 8 0 0.198 0.553 1.000 56 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), HLA-DRB1(1), IL1B(3), IL5RA(4), IL6(1) 1455578 11 10 11 2 2 5 0 0 4 0 0.313 0.555 1.000 57 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(7), ABCB11(6), ABCB4(4), ABCC1(3), ABCC3(2), GSTP1(1) 4014069 23 22 21 0 2 9 6 1 5 0 0.00117 0.563 1.000 58 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(4), FUT1(1), FUT9(4) 1675929 9 9 9 0 5 3 0 1 0 0 0.0392 0.569 1.000 59 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), PTPRU(7), REG1A(1), STAT1(3) 3156241 18 17 18 1 6 5 1 1 5 0 0.0211 0.577 1.000 60 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PDXP(3), PNPO(2), PSAT1(3) 1312884 12 12 12 4 2 6 2 1 1 0 0.600 0.603 1.000 61 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), TGDS(2), UGDH(3), UXS1(1) 1384425 7 7 7 1 1 2 1 1 2 0 0.527 0.618 1.000 62 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR3(1), PAK1(2), PDGFRA(4), PIK3R1(5), RAC1(1), WASL(2) 3106486 15 15 15 2 3 1 1 4 6 0 0.288 0.644 1.000 63 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(3), ACAT2(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 2325113 13 12 13 1 1 8 0 0 4 0 0.193 0.649 1.000 64 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(2), CDKN1A(2), CHEK1(1), NEK1(3), WEE1(1) 2118074 12 12 12 2 3 6 0 1 2 0 0.330 0.649 1.000 65 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(3) 812690 4 4 4 1 0 2 1 0 1 0 0.683 0.651 1.000 66 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), IDH2(4), MDH1(2), OGDH(2), SDHA(4) 2609673 13 13 13 0 4 5 1 1 2 0 0.0127 0.651 1.000 67 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(12), ESR1(6), MAPK1(1), PELP1(3) 3966827 35 30 35 6 7 11 5 2 10 0 0.110 0.653 1.000 68 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(2), SHMT1(2), SHMT2(2) 1595795 8 8 8 1 2 2 1 1 2 0 0.303 0.654 1.000 69 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 310721 1 1 1 0 0 1 0 0 0 0 0.743 0.660 1.000 70 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(4), F2R(4), F5(4), F7(1), FGA(4), FGB(3), FGG(1), PROC(1), PROS1(5), TFPI(2) 4498404 31 27 30 4 5 9 6 4 7 0 0.0977 0.661 1.000 71 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(2), FSHR(6), GNAS(16), XPO1(4) 2613014 33 29 32 7 10 9 3 5 6 0 0.387 0.662 1.000 72 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1) 3296820 23 21 23 3 8 8 2 1 4 0 0.0564 0.678 1.000 73 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(2), ACO2(1), ACSS1(2), ACSS2(8), IDH1(1), IDH2(4), MDH1(2), MDH2(2) 3642127 24 19 24 1 3 16 0 3 2 0 0.00435 0.682 1.000 74 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 412019 1 1 1 0 0 0 0 0 1 0 0.803 0.684 1.000 75 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(1), IDH1(1), IDH2(4), MDH1(2), MDH2(2) 2453598 12 12 12 0 3 7 0 1 1 0 0.0289 0.684 1.000 76 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), ECHS1(1), HADH(1), HADHA(2), HSD17B4(4), PPT1(1), PPT2(1) 2357126 14 13 14 2 2 7 0 1 4 0 0.312 0.691 1.000 77 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), PC(1), PCK1(2), SDHA(4), SUCLG1(2), SUCLG2(1) 5674098 31 28 30 1 5 15 3 1 7 0 0.00129 0.695 1.000 78 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(3), SNCAIP(4), UBE2F(1), UBE2G2(1), UBE2L6(1) 1699678 12 11 12 3 3 4 1 1 3 0 0.433 0.700 1.000 79 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(1), MUT(3) 1333526 7 7 7 0 1 3 1 1 1 0 0.132 0.713 1.000 80 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(2), IDI1(1), SQLE(1) 921844 6 6 6 2 0 5 1 0 0 0 0.647 0.716 1.000 81 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(1) 942886 4 4 4 0 0 2 0 0 2 0 0.617 0.724 1.000 82 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(2), APOBEC2(2), APOBEC3F(1), APOBEC3G(2), APOBEC4(2) 2013603 14 13 14 3 4 8 1 1 0 0 0.293 0.729 1.000 83 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(6), CSF1R(9), EGF(4), EGFR(5), MET(4), PDGFRA(4), PRKCA(1), SH3GLB1(2), SH3GLB2(2), SH3KBP1(5) 5320627 42 35 42 6 6 20 2 6 8 0 0.0442 0.736 1.000 84 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), PANK1(3), PANK2(4), PANK3(4), PANK4(4) 3853861 34 33 34 8 4 17 3 4 6 0 0.255 0.741 1.000 85 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADS(2), ACADVL(2), ACSL1(2), ACSL3(3), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(1), HADHA(2), SCP2(1) 4590338 22 20 22 0 4 10 2 1 5 0 0.00218 0.761 1.000 86 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), SHMT1(2), SHMT2(2) 1212733 5 5 5 1 1 2 1 0 1 0 0.521 0.784 1.000 87 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(2), ACO2(1), CLYBL(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), OGDHL(6), PC(1), PCK1(2), PCK2(2), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1) 8196688 46 37 45 1 9 20 5 3 9 0 1.41e-05 0.787 1.000 88 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), SDS(1) 2178288 11 10 11 1 1 8 0 0 2 0 0.197 0.798 1.000 89 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(1), CDK2(1), CDKN1A(2), CFL1(1), E2F1(2), E2F2(2), MDM2(2), NXT1(1), PRB1(2) 1927303 15 12 15 3 2 5 0 3 5 0 0.308 0.805 1.000 90 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), GSK3B(3), PPP1CA(1) 3132538 14 13 14 1 2 6 2 0 3 1 0.0728 0.808 1.000 91 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), CDKN2C(1), CDKN2D(1), E2F1(2), RB1(8), RBL1(2), TFDP1(1) 4321184 30 25 30 5 1 9 3 4 13 0 0.179 0.809 1.000 92 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(5), PRKCA(1), PTK2B(4) 1797444 10 10 10 2 2 5 0 0 3 0 0.342 0.814 1.000 93 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(2), IDI1(1), IDI2(1), SQLE(1) 1216703 7 7 7 2 1 5 1 0 0 0 0.555 0.815 1.000 94 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(2), GAD1(3), GAD2(2) 1618379 7 7 7 1 1 4 0 0 2 0 0.408 0.815 1.000 95 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD1(1), GLUD2(4) 1225159 7 6 7 2 1 4 1 0 1 0 0.555 0.826 1.000 96 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(4), ACOX3(1), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3) 2941902 17 16 17 2 6 7 0 0 4 0 0.0619 0.829 1.000 97 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2) 3490731 19 17 19 2 3 9 5 1 1 0 0.0607 0.832 1.000 98 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(3), MST1R(7) 1780726 11 8 11 1 1 5 0 2 3 0 0.182 0.833 1.000 99 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3) 2906993 15 14 15 2 2 2 5 4 2 0 0.216 0.834 1.000 100 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3) 2906993 15 14 15 2 2 2 5 4 2 0 0.216 0.834 1.000 101 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(2), B3GNT5(1), FUT1(1), FUT3(2), ST3GAL3(1), ST3GAL4(1) 1943274 8 8 8 0 2 3 0 3 0 0 0.0962 0.835 1.000 102 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), INSR(9), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3) 6376148 45 36 45 6 12 11 7 4 11 0 0.0250 0.840 1.000 103 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(3), STAT1(3), STAT2(4), TYK2(3) 3035561 15 14 15 1 4 5 2 3 1 0 0.0615 0.846 1.000 104 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(1), CD3E(1), IFNG(1), IL2RA(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR3(3), TOB1(2), TOB2(1) 2569673 15 14 15 3 1 8 1 5 0 0 0.363 0.850 1.000 105 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(1), AFMID(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2) 3668877 20 18 20 2 4 9 5 1 1 0 0.0447 0.859 1.000 106 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), ST3GAL5(1) 1481459 7 7 7 1 1 2 2 2 0 0 0.367 0.865 1.000 107 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(3), CDC25B(2), CSK(2), PRKCA(1), PTPRA(4) 2558073 13 13 13 2 3 8 0 0 2 0 0.138 0.876 1.000 108 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), DLD(4), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), PC(1), PDHA2(5), PDHX(1), PDK2(1), PDK3(2), PDK4(1), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1) 7832029 41 39 40 4 6 16 7 1 11 0 0.00918 0.879 1.000 109 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(2), FARSB(1), PAH(4), TAT(2), YARS(1), YARS2(2) 2404317 12 12 12 3 1 3 3 1 4 0 0.484 0.879 1.000 110 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(2), TYR(3) 1270875 7 7 7 2 3 2 1 0 1 0 0.527 0.883 1.000 111 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(14), MAP2(11), PPP1CA(1), PPP2CA(1), PRKAG1(1), PRKAR2B(3), PRKCE(2) 4782075 33 28 33 5 4 10 5 8 6 0 0.136 0.889 1.000 112 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 718746 2 2 2 0 0 1 0 0 1 0 0.500 0.889 1.000 113 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(4), NTAN1(2), SIRT1(5), SIRT5(1), SIRT7(1) 3274960 21 18 21 4 5 11 2 0 3 0 0.236 0.902 1.000 114 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD80(1), HLA-DRB1(1), IL10(2) 1079094 5 5 5 2 1 2 1 0 1 0 0.761 0.904 1.000 115 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(1), BAX(2), BCL10(1), BCL2L1(1), BCL2L11(3), BID(1), CASP9(1), CES1(5) 3071027 18 17 18 4 6 5 3 0 4 0 0.298 0.906 1.000 116 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), THTPA(1) 1739953 9 6 8 2 0 4 1 0 4 0 0.556 0.917 1.000 117 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRB1(1) 640755 2 2 2 2 0 1 0 0 1 0 0.970 0.923 1.000 118 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(5), GNAS(16), GNGT1(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1) 2672013 28 27 28 7 12 6 2 1 6 1 0.334 0.923 1.000 119 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2), MASP1(4), MBL2(4) 5944043 42 36 42 7 7 18 2 7 8 0 0.0684 0.924 1.000 120 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), PGM1(1), TGDS(2) 2859277 11 11 11 1 3 5 0 0 3 0 0.132 0.924 1.000 121 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(3) 2511337 16 14 16 4 3 9 2 0 2 0 0.339 0.928 1.000 122 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2) 4876386 34 30 34 6 6 14 2 6 6 0 0.147 0.933 1.000 123 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2) 3485087 28 25 28 6 4 12 2 5 5 0 0.327 0.935 1.000 124 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(3), JAK2(2), JAK3(6), PIAS3(1), PTPRU(7), REG1A(1), STAT3(2) 4245760 24 23 24 4 7 5 3 3 6 0 0.0943 0.937 1.000 125 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C8B(3), C9(2), MASP1(4) 5775304 41 34 41 7 8 15 3 7 8 0 0.0829 0.941 1.000 126 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), GNAS(16), PLCE1(10), PRKAR1B(2), PRKAR2B(3), RAP2B(1) 4033559 38 34 38 9 12 12 3 4 7 0 0.284 0.942 1.000 127 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), ST3GAL6(1) 4317984 26 23 26 4 9 9 4 3 1 0 0.0578 0.943 1.000 128 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), STAT1(3) 2255006 10 9 10 2 2 4 1 1 2 0 0.413 0.944 1.000 129 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(6), ABCG2(6), BCHE(9), CES1(5), CES2(1), CYP3A5(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2) 6256205 42 35 42 7 9 13 5 3 12 0 0.0458 0.944 1.000 130 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), L2HGDH(3), PDHA2(5), SDS(1) 7031960 48 39 48 6 11 19 4 5 9 0 0.0100 0.944 1.000 131 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(4), CREB5(2), MAPK1(1), RAF1(2), SNX13(6), TERF2IP(1) 3193499 16 15 16 3 1 8 1 5 1 0 0.324 0.945 1.000 132 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(2), DHRSX(1), HSD3B7(2), PON1(1), PON2(2), PON3(4), RDH13(1) 2430675 14 12 14 4 2 1 4 3 4 0 0.612 0.946 1.000 133 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), FLT3(9), IGF1(1), IL3(2), IL6(1), KITLG(2), TGFB2(1), TGFB3(2) 2330556 20 17 20 5 2 7 3 1 7 0 0.357 0.951 1.000 134 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), ISYNA1(1), PGM1(1), TGDS(2) 3250139 12 12 12 1 3 5 0 1 3 0 0.106 0.952 1.000 135 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(1), PPARG(2), RETN(1) 1561641 7 7 7 2 3 0 0 0 4 0 0.657 0.954 1.000 136 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(1), GLS(2), GLUD1(1), OAT(3) 1616974 11 11 11 4 3 3 3 0 2 0 0.598 0.954 1.000 137 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(4), XDH(9) 2230932 14 14 14 4 1 5 5 1 2 0 0.489 0.958 1.000 138 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT3(2), FUT5(1), FUT6(2), ST3GAL3(1) 1399674 7 7 7 2 3 3 0 1 0 0 0.442 0.958 1.000 139 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3E(1), CD58(1), CSF3(2), IL3(2), IL6(1), KITLG(2) 1727349 12 10 12 4 2 5 1 1 3 0 0.625 0.961 1.000 140 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(2), CASP8(6), FADD(1), RIPK1(2), TNFRSF1B(1), TRAF2(1) 2290847 13 11 13 3 3 3 2 2 3 0 0.399 0.961 1.000 141 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(13), DFFA(1), DFFB(2), GZMA(1), HMGB2(1), PRF1(4), SET(3) 2890230 26 24 26 7 7 7 2 2 8 0 0.457 0.965 1.000 142 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25A(3), CDC25B(2), MNAT1(1), XPO1(4) 2377248 11 9 10 3 2 4 0 2 3 0 0.691 0.966 1.000 143 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), PAPSS2(3), SCLY(2), SEPHS1(3) 3449819 17 15 17 3 5 4 3 2 3 0 0.157 0.966 1.000 144 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM3(1), CDKN1A(2), GNAQ(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SP1(1), SP3(2), SYT1(3) 5487856 38 33 38 7 10 14 2 5 7 0 0.0906 0.968 1.000 145 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 606620 1 1 1 0 0 1 0 0 0 0 0.721 0.968 1.000 146 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(2), NDUFA1(1), SDHA(4), SDHD(2) 1773501 11 11 11 4 1 5 2 0 3 0 0.754 0.969 1.000 147 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(4), AKT2(1), AKT3(2), CDKN1A(2), ELK1(2), HRAS(1), MAP2K1(2), MAP2K2(3), NGFR(2), NTRK1(5), PIK3CD(5), SOS1(3) 4028396 32 28 32 7 13 9 2 5 3 0 0.116 0.970 1.000 148 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(1), AKT1(4), CALM3(1), GNAS(16), GNGT1(1), NFKB1(2), NOS3(5), NR3C1(1), PIK3R1(5), SYT1(3) 4395237 39 37 39 9 14 9 4 1 11 0 0.247 0.971 1.000 149 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB1A(1), RAB27A(2), RAB4A(1), RAB5A(1) 1164903 6 6 6 3 2 3 0 0 1 0 0.800 0.973 1.000 150 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(4), HRAS(1), KLK2(1), NTRK1(5), PIK3R1(5), PLCG1(5), PRKCA(1), SOS1(3) 3692857 25 22 25 5 8 6 2 3 6 0 0.240 0.973 1.000 151 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(2), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 1896878 14 11 14 4 3 8 0 1 2 0 0.402 0.973 1.000 152 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FOS(1), FYN(1), JUN(1), MAPK14(1), THBS1(2) 1986112 8 8 8 2 1 3 2 0 2 0 0.649 0.973 1.000 153 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(1) 866172 3 3 3 2 1 2 0 0 0 0 0.820 0.973 1.000 154 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), LPO(3), MPO(3), PRDX6(3), TPO(8) 2329253 21 20 21 6 6 4 2 3 6 0 0.398 0.974 1.000 155 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), MKNK1(1), PDK2(1), PIK3R1(5), PPP2CA(1), TSC1(10), TSC2(7) 6865638 44 39 44 8 5 11 7 3 18 0 0.111 0.974 1.000 156 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(3), HDC(2), TH(3), TPH1(2) 1655011 11 9 11 3 4 5 0 2 0 0 0.371 0.974 1.000 157 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(4), MMP2(3), MMP9(3), RECK(4), TIMP3(2), TIMP4(2) 2133835 19 18 19 5 7 7 0 2 3 0 0.304 0.977 1.000 158 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(1), BMPR1B(4), BMPR2(3) 1666481 9 9 9 3 0 4 4 0 1 0 0.706 0.977 1.000 159 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2), NDUFA13(1) 1178758 4 4 4 2 1 2 1 0 0 0 0.766 0.977 1.000 160 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(2), ATM(22), ATR(5), CCNA1(3), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), E2F1(2), GSK3B(3), HDAC1(1), RB1(8), TFDP1(1), TGFB2(1), TGFB3(2) 7902573 61 49 61 10 4 19 8 9 21 0 0.0575 0.978 1.000 161 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8) 3283440 27 26 27 7 7 7 4 3 6 0 0.282 0.978 1.000 162 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(3), RANBP2(6), RANGAP1(1) 2355983 10 7 10 2 0 6 3 0 1 0 0.572 0.979 1.000 163 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10(2), IL10RA(3), IL10RB(1), IL6(1), JAK1(3), STAT1(3), STAT3(2), STAT5A(3) 3357001 22 16 21 4 4 8 2 2 6 0 0.112 0.980 1.000 164 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(3), CCNA2(1), CCND1(1), CCNE1(2), CDK2(1), E2F1(2), E2F2(2), PRB1(2) 2366915 14 12 14 4 3 3 2 3 3 0 0.464 0.980 1.000 165 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), MIOX(2), UGDH(3) 2301132 16 14 16 4 6 6 0 1 3 0 0.405 0.981 1.000 166 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(5), AASS(3), KARS(2) 1892480 11 11 11 4 1 6 1 1 2 0 0.793 0.981 1.000 167 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(13), EP300(12), FYN(1), IL2RG(3), IL7R(3), JAK1(3), JAK3(6), LCK(1), PIK3R1(5), PTK2B(4), STAT5A(3), STAT5B(2) 7053819 56 48 56 10 11 14 5 6 20 0 0.107 0.982 1.000 168 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), CKM(1), FBL(2), GPT(4), MAPK14(1), NCL(5) 2510653 14 13 14 4 6 2 0 1 5 0 0.543 0.983 1.000 169 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIK(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), ENDOG(1) 3742336 25 20 25 6 6 8 3 1 7 0 0.376 0.984 1.000 170 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(1), CD3E(1), CD80(1), CD86(1), HLA-DRB1(1), ITK(7), LCK(1), PIK3R1(5), PTPN11(2) 2887608 20 19 20 5 5 4 4 1 6 0 0.462 0.986 1.000 171 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(5), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), SDS(1) 7903442 52 45 52 9 16 19 5 3 9 0 0.0251 0.987 1.000 172 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(3), NR0B2(1), NR1H4(2) 1487957 7 7 7 3 1 3 1 0 2 0 0.726 0.987 1.000 173 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(4), FYN(1), LRP8(3), RELN(17) 3792313 26 24 24 6 5 13 2 3 3 0 0.309 0.987 1.000 174 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(3), AGT(1), AGTR2(2), KNG1(2), NOS3(5), REN(2) 2712517 15 14 15 4 1 8 2 0 4 0 0.375 0.988 1.000 175 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1), ITPKB(6) 1545526 8 7 8 7 1 4 0 0 3 0 0.966 0.988 1.000 176 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 EIF1(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), ELAVL1(3), FLT1(7), FLT4(5), HIF1A(5), HRAS(1), KDR(5), NOS3(5), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PXN(3) 8851748 58 46 57 9 13 23 3 8 11 0 0.0184 0.989 1.000 177 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(4), CASP9(1), CHUK(5), GH1(1), GHR(2), NFKB1(2), PIK3R1(5), PPP2CA(1) 3283365 21 19 21 9 3 5 5 0 8 0 0.892 0.990 1.000 178 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(4), GLI2(5), GLI3(9), GSK3B(3), PRKAR1B(2), PRKAR2B(3), SMO(4), SUFU(2) 4490658 36 29 36 9 5 12 5 4 10 0 0.333 0.990 1.000 179 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(2), ATM(22), BRCA1(6), CDKN1A(2), CHEK1(1), CHEK2(3), JUN(1), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(2), RAD50(3), RAD51(3), RBBP8(3), TP73(3) 7795081 56 42 53 9 7 23 5 8 13 0 0.0919 0.990 1.000 180 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(1), F2(4), F2R(4), FGA(4), FGB(3), FGG(1), PLAT(1), PLG(3), SERPINB2(2) 3679760 24 20 23 5 4 7 3 1 9 0 0.404 0.990 1.000 181 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(11), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1) 2341377 21 20 21 9 5 8 2 0 6 0 0.712 0.991 1.000 182 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(3), HSD17B1(1), HSD17B4(4), HSD3B1(2), HSD3B2(3) 2189461 14 9 14 3 2 7 2 0 3 0 0.438 0.991 1.000 183 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), BIRC3(2), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), LMNA(2), LMNB1(1), LMNB2(5), PRF1(4) 5263175 37 31 37 7 8 13 5 2 9 0 0.140 0.992 1.000 184 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), CD3E(1), HLA-A(1), ICAM1(1), ITGAL(6), PRF1(4) 2368742 17 15 17 8 2 6 0 3 6 0 0.860 0.993 1.000 185 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD14(1), RPN1(3), RPN2(3), UBE3A(3) 3659562 22 18 22 5 3 9 2 4 4 0 0.311 0.993 1.000 186 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(4), AOC3(5), CES1(5), DDHD1(4), ESCO1(3), ESCO2(1), PLA1A(1), PPME1(1), PRDX6(3), SH3GLB1(2) 6815960 29 26 29 4 8 8 2 2 9 0 0.0473 0.994 1.000 187 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRB1(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL2RA(1), IL4R(3) 3466155 16 14 16 4 0 6 2 5 3 0 0.622 0.994 1.000 188 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), CHRM1(2), CHRM3(5), CHRM4(2), CHRM5(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), HRH1(2), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3) 6652576 66 57 66 16 20 24 6 8 8 0 0.0161 0.994 1.000 189 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(5), IFNG(1), IKBKB(2), JUN(1), MAP3K1(8), MAP3K5(8), MAP4K5(6), MAPK14(1), MAPK8(1), NFKB1(2), TNFRSF9(1), TNFSF9(2), TRAF2(1) 5427842 39 28 39 9 7 11 6 5 10 0 0.460 0.995 1.000 190 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IGF1(1), IGF1R(4), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3) 6214422 41 31 41 9 10 10 7 3 11 0 0.276 0.995 1.000 191 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PDGFA(2), PDGFRA(4), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3) 9014104 62 47 62 10 15 18 9 5 15 0 0.0332 0.995 1.000 192 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(4), CHRNB1(6), CHRNG(3), MUSK(2), PIK3R1(5), PTK2(1), PTK2B(4), RAPSN(2), TERT(2) 4005109 29 25 29 9 11 5 1 1 11 0 0.445 0.995 1.000 193 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), P2RY1(2), P2RY6(2) 1518997 14 13 14 5 3 7 1 2 1 0 0.414 0.995 1.000 194 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASS(3), KARS(2) 1296491 6 6 6 3 1 2 1 1 1 0 0.860 0.995 1.000 195 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), FDXR(2), SHMT1(2) 4409891 19 18 19 4 5 4 2 5 3 0 0.346 0.995 1.000 196 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), SQLE(1) 3675562 17 17 17 4 2 10 1 0 4 0 0.402 0.996 1.000 197 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(4), EGFR(5), HGS(1), RAB5A(1), TF(4), TFRC(2) 3504948 19 17 19 5 2 11 4 0 2 0 0.376 0.996 1.000 198 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), CAMKK2(4), SYT1(3) 3213717 16 15 16 4 7 3 3 0 3 0 0.330 0.996 1.000 199 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(22), BMPR1B(4), DMC1(2), EGR1(2), ESR2(1), FSHR(6), INHA(1), LHCGR(6), MLH1(2), MSH5(1), NCOR1(4), NRIP1(3), PGR(5), PRLR(3), PTGER2(1), SMPD1(2), VDR(2), ZP2(1) 9437626 68 57 68 11 9 25 8 10 15 1 0.0153 0.996 1.000 200 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), FUT8(2), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), RPN1(3), RPN2(3) 5383550 34 32 34 8 7 13 5 4 5 0 0.192 0.996 1.000 201 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(5), CREBBP(13), EP300(12), FADD(1), HDAC3(3), IKBKB(2), NFKB1(2), RIPK1(2), TNFRSF1B(1), TRAF6(1) 6102439 42 35 42 9 6 12 6 3 15 0 0.282 0.996 1.000 202 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(3), PAH(4), TAT(2), YARS(1) 2256562 11 11 11 4 1 3 3 2 2 0 0.672 0.997 1.000 203 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), EIF4EBP1(1), IFNG(1), IL1R1(1), NR4A3(2), WDR1(1) 2948940 8 8 8 2 2 2 0 0 4 0 0.356 0.997 1.000 204 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5) 1874055 5 5 5 2 2 2 0 1 0 0 0.709 0.997 1.000 205 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(4), INPPL1(2), PDK2(1), PIK3R1(5), PPP2CA(1) 4667415 27 26 27 6 4 6 5 1 11 0 0.308 0.997 1.000 206 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(2), ME1(1), PC(1), SLC25A1(1) 2561793 7 7 7 1 2 3 1 1 0 0 0.296 0.997 1.000 207 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3) 1828015 15 13 15 5 6 4 1 1 3 0 0.567 0.997 1.000 208 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3) 1828015 15 13 15 5 6 4 1 1 3 0 0.567 0.997 1.000 209 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(4), EPHB2(4), F2(4), F2RL1(1), F2RL2(1), F2RL3(2), JUN(1), MAP2K5(2), MAPK1(1), MAPK7(1), MAPK8(1), MYEF2(2), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RAF1(2), TEC(1), VAV1(8) 7570878 45 40 44 9 10 15 5 3 12 0 0.142 0.997 1.000 210 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1) 2705823 11 11 11 3 4 4 1 2 0 0 0.438 0.997 1.000 211 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), MBTPS1(4), MBTPS2(5), SCAP(4), SREBF1(3), SREBF2(2) 3246479 21 18 20 6 4 9 1 3 4 0 0.389 0.997 1.000 212 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(15), CDH1(1), CREBBP(13), EP300(12), MAP2K1(2), MAP3K7(3), SKIL(2), TGFB2(1), TGFB3(2), TGFBR1(2) 6515896 53 45 51 11 7 17 7 5 17 0 0.286 0.997 1.000 213 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TPO(8), TYR(3) 2686387 25 24 25 8 7 6 4 3 5 0 0.468 0.997 1.000 214 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(1), CSF3(2), IL3(2), IL6(1) 1714946 6 5 6 7 2 1 0 0 3 0 0.995 0.998 1.000 215 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), HSD3B7(2), RDH13(1) 1333296 5 5 5 3 1 2 0 1 1 0 0.801 0.998 1.000 216 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1) 4789116 19 19 19 4 5 7 3 3 1 0 0.253 0.998 1.000 217 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ADSL(3), AGXT(2), ASL(3), ASNS(5), ASPA(2), CAD(11), CRAT(2), DDO(1), GAD1(3), GAD2(2), GPT(4), GPT2(1), PC(1) 7233311 43 36 43 6 14 12 6 5 6 0 0.0292 0.998 1.000 218 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(4), CYP1A2(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), RDH13(1) 6790113 35 28 35 6 11 14 2 4 4 0 0.0570 0.998 1.000 219 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 220 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 221 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2) 4165043 17 16 17 4 4 3 2 5 3 0 0.468 0.998 1.000 222 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM3(1), CAPN2(1), CAPNS1(3), CAPNS2(1), EP300(12), HDAC1(1), MEF2D(3), NFATC1(4), NFATC2(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SYT1(3) 6558104 50 44 49 11 13 18 4 2 13 0 0.0837 0.999 1.000 223 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), LPO(3), MPO(3), MTHFR(2), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8) 3180236 25 24 25 8 7 6 3 2 7 0 0.479 0.999 1.000 224 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(3), CP(3), CPOX(1), EPRS(3), FECH(1), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UROD(1), UROS(1) 7468091 37 34 37 6 9 12 5 5 6 0 0.0578 0.999 1.000 225 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(2), PTGS1(2) 1463913 5 4 5 3 1 3 0 0 1 0 0.789 0.999 1.000 226 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(2), COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), ILVBL(1), PANK1(3), PANK2(4), PANK3(4), PANK4(4), PPCDC(1), VNN1(4) 4829209 42 40 42 11 5 23 4 4 6 0 0.266 0.999 1.000 227 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3) 1544872 9 9 9 7 4 3 0 1 1 0 0.948 0.999 1.000 228 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(1), PTK2B(4), SOS1(3) 2381055 8 8 8 3 1 3 0 2 2 0 0.787 0.999 1.000 229 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(5), DNAJC3(1), EIF2S1(1), NFKB1(2) 2553241 9 8 9 3 1 4 1 0 3 0 0.776 0.999 1.000 230 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1) 1971862 8 6 8 3 4 2 0 0 2 0 0.624 0.999 1.000 231 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EARS2(1), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), GMPS(3), GPT(4), GPT2(1), GSR(3), NADSYN1(2), NAGK(2), QARS(3) 10865694 70 54 70 10 14 25 9 10 12 0 0.00836 0.999 1.000 232 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), HEMK1(1), LCMT1(1), METTL2B(1), PCYT1A(2), PCYT1B(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1) 3854921 17 15 17 4 4 8 1 1 3 0 0.331 0.999 1.000 233 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(1), ALDH18A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), ASS1(1), CPS1(11), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(1), OTC(1), SAT1(1), SRM(3) 8066661 59 47 59 11 14 16 6 7 16 0 0.0620 0.999 1.000 234 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(6), ADSL(3), ADSSL1(1), AGXT(2), ASL(3), ASNS(5), ASPA(2), ASRGL1(2), ASS1(1), CAD(11), CRAT(2), DARS2(2), DDO(1), DLAT(1), DLD(4), GAD1(3), GAD2(2), GPT(4), GPT2(1), NARS2(1), PC(1), PDHA2(5) 10502296 66 52 66 9 18 21 11 5 11 0 0.00647 0.999 1.000 235 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PGK1(1), PKLR(3), RPE(1), RPIA(1), TKT(1) 4869690 29 27 29 7 8 11 1 2 7 0 0.238 0.999 1.000 236 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(1), GSK3B(3), MAPT(1), PPP2CA(1) 2637756 17 15 17 5 3 8 3 0 3 0 0.380 0.999 1.000 237 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(1), GOSR1(1), GOSR2(1), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(3), STX17(2), STX18(1), STX19(2), STX2(1), STX5(1), STX6(2), VAMP4(2), VAMP5(1), VAMP8(1), VTI1A(3), YKT6(1) 4696263 29 28 29 7 7 9 5 4 4 0 0.345 0.999 1.000 238 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(3), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), GAMT(1), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(1), OTC(1) 4944513 35 29 35 9 6 11 6 3 9 0 0.321 0.999 1.000 239 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CRY1(1), CRY2(2), CSNK1E(1), PER1(5) 2313732 11 10 11 5 3 4 1 0 3 0 0.717 0.999 1.000 240 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(15), AXIN1(2), BTRC(3), CCND1(1), CREBBP(13), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(9), FRAT1(1), FZD1(4), GSK3B(3), HDAC1(1), MAP3K7(3), NLK(4), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1) 8075869 69 49 67 14 13 17 12 4 22 1 0.126 0.999 1.000 241 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), AMT(1), ATIC(2), ATP6V0C(1), GART(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2) 4921193 33 30 33 9 3 13 8 5 4 0 0.372 0.999 1.000 242 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2G2(1), UBE2H(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(3) 2941220 16 15 16 5 1 7 0 5 3 0 0.664 1.000 1.000 243 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(1), AGTR2(2), EDNRA(1), EDNRB(3), EGF(4), EGFR(5), FOS(1), HRAS(1), JUN(1), NFKB1(2), PLCG1(5), PRKCA(1) 5583048 34 32 34 8 7 15 5 2 5 0 0.192 1.000 1.000 244 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNGT1(1), HTR2C(1), PLCB1(3), TUB(3) 1946427 11 11 11 5 2 3 1 3 2 0 0.802 1.000 1.000 245 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(4), APC(15), AXIN1(2), CCND1(1), CD14(1), CTNNB1(9), FZD1(4), GJA1(1), GNAI1(1), GSK3B(3), IRAK1(2), NFKB1(2), PIK3R1(5), PPP2CA(1), TLR4(6), TOLLIP(1), WNT1(1) 7633930 59 46 58 12 7 12 16 3 20 1 0.166 1.000 1.000 246 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), HIBCH(4), SRM(3) 7344068 45 37 45 9 14 19 3 3 6 0 0.0527 1.000 1.000 247 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JUN(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3R1(5), PLCG1(5), RAF1(2), SOS1(3) 4663270 27 24 27 7 8 7 3 3 6 0 0.401 1.000 1.000 248 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(3), ADCY9(6), ARF1(1), ARF4(1), ARF5(1), ARF6(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), GNAS(16), PDIA4(3), PLCG1(5), PLCG2(3), PRKCA(1), SEC61A1(3), SEC61A2(1), TRIM23(2) 10180114 67 55 66 12 25 20 7 8 7 0 0.0162 1.000 1.000 249 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), LPO(3), MAOA(2), MAOB(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TAT(2), TPO(8) 6134079 45 40 45 10 15 8 4 7 11 0 0.0847 1.000 1.000 250 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(1), BIRC3(2), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), PRF1(4), SCAP(4), SREBF1(3), SREBF2(2) 4969809 30 28 30 8 8 11 2 4 5 0 0.370 1.000 1.000 251 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MAX(1), SP1(1), SP3(2), WT1(4) 1673819 9 9 9 5 2 3 1 2 1 0 0.880 1.000 1.000 252 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GLS(2), GLUD1(1), GLUL(2), GMPS(3), GPT(4), GPT2(1), NADSYN1(2), QARS(3) 9126465 57 46 57 10 13 19 8 8 9 0 0.0559 1.000 1.000 253 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), RFK(1), TYR(3) 2694367 19 19 19 7 2 9 3 2 3 0 0.729 1.000 1.000 254 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CRY1(1), CRY2(2), CSNK1D(1), CSNK1E(1), NPAS2(4), NR1D1(2), PER1(5), PER2(5), PER3(5) 4614200 28 22 28 7 8 13 2 1 4 0 0.174 1.000 1.000 255 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 2740879 19 15 19 6 5 10 1 1 2 0 0.461 1.000 1.000 256 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3) 2740879 19 15 19 6 5 10 1 1 2 0 0.461 1.000 1.000 257 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(2), LDHAL6A(3), LDHAL6B(1), SDS(1), SULT1C2(2) 3507694 14 11 14 4 5 6 0 2 1 0 0.386 1.000 1.000 258 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM3(1), CCR5(1), CXCR4(1), FOS(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(1), PLCG1(5), PRKCA(1), PTK2B(4), SYT1(3) 3755123 21 21 21 6 6 7 2 1 5 0 0.425 1.000 1.000 259 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(4), MAF(1), MAPK14(1), NFATC1(4), NFATC2(6), PRKAR1B(2), PRKAR2B(3) 3262568 21 16 21 7 7 4 3 1 6 0 0.555 1.000 1.000 260 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(4), LARS(4), LARS2(2), PDHA2(5) 2698533 15 15 15 5 1 4 4 3 3 0 0.717 1.000 1.000 261 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(3), NFKB1(2), NOX1(1), XDH(9) 2757859 15 15 15 5 0 6 5 1 3 0 0.642 1.000 1.000 262 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(2), PLCB1(3), PRKCA(1) 2262604 7 7 7 5 0 4 0 1 2 0 0.942 1.000 1.000 263 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), TNFAIP3(5), TRAF3(1), TRAF6(1) 5059398 30 24 30 7 3 8 4 6 9 0 0.506 1.000 1.000 264 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), COPA(8), GBF1(5), GPLD1(2), KDELR1(1), KDELR2(2) 4447722 25 21 25 7 6 7 4 5 3 0 0.463 1.000 1.000 265 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(6), GPR18(1), GPR34(1), GPR39(1), GPR45(1), GPR68(1), GPR75(1) 2554947 13 12 13 5 5 3 4 1 0 0 0.551 1.000 1.000 266 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(1), EGF(4), EGFR(5), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3) 9688528 65 45 65 12 13 24 8 5 15 0 0.0649 1.000 1.000 267 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9) 2887395 19 18 19 7 1 12 2 1 3 0 0.506 1.000 1.000 268 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CXCR3(1), ETV5(2), IFNG(1), IL12B(1), IL12RB2(5), IL18R1(1), JAK2(2), JUN(1), MAPK14(1), MAPK8(1), STAT4(5), TYK2(3) 5190287 26 25 26 7 5 8 3 5 5 0 0.444 1.000 1.000 269 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP3A43(1), CYP3A5(2), CYP3A7(1), DHRS1(1), DHRS3(2), DHRSX(1), PON1(1), PON2(2), PON3(4) 4956073 26 23 26 7 5 6 5 3 7 0 0.415 1.000 1.000 270 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), SQLE(1), VKORC1(1) 3085867 16 15 16 5 2 8 2 1 3 0 0.554 1.000 1.000 271 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), GGCX(2), HMGCR(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), SQLE(1), VKORC1(1) 5318329 24 23 24 5 5 13 1 1 4 0 0.195 1.000 1.000 272 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(4), ALOX5AP(1), DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), PTGS1(2), TBXAS1(2) 4389941 24 20 24 7 12 5 1 1 5 0 0.343 1.000 1.000 273 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(2), FOSL2(1), IFNAR1(1), IFNB1(1), MAPK8(1), NFKB1(2), TNFRSF11A(1), TRAF6(1) 3042812 11 10 11 4 1 4 2 0 4 0 0.745 1.000 1.000 274 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2) 4287148 10 10 10 2 2 3 1 0 4 0 0.536 1.000 1.000 275 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5A(2), GPRC5B(3), GPRC5C(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM7(3), GRM8(11) 5612865 60 49 60 16 20 17 8 7 8 0 0.135 1.000 1.000 276 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(8), PGM1(1), PYGL(3), PYGM(4) 3816428 17 14 17 5 3 8 2 1 3 0 0.500 1.000 1.000 277 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), CALM3(1), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PAK2(1), PIK3R1(5), PLA2G4A(1), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8) 11066042 76 58 76 14 20 21 9 7 19 0 0.0330 1.000 1.000 278 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3) 6288927 57 46 57 13 16 18 5 3 15 0 0.152 1.000 1.000 279 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3) 6288927 57 46 57 13 16 18 5 3 15 0 0.152 1.000 1.000 280 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(2), CR2(4), FCGR2B(1), HLA-DRB1(1), ICAM1(1), ITGAL(6), PTPRC(9) 4195132 25 24 24 9 3 11 2 2 7 0 0.650 1.000 1.000 281 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM3(1), CD3E(1), ELK1(2), FOS(1), FYN(1), HRAS(1), JUN(1), LCK(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PIK3R1(5), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PTPN7(1), RAC1(1), RAF1(2), RASA1(9), SOS1(3), SYT1(3), VAV1(8), ZAP70(3) 12450689 88 66 88 16 23 27 9 7 22 0 0.0184 1.000 1.000 282 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCKDHA(2), BCKDHB(3), ECHS1(1), EHHADH(1), HADHA(2), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1) 9879172 63 51 63 12 11 28 6 2 16 0 0.0882 1.000 1.000 283 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1) 2400666 11 9 11 6 2 4 1 2 2 0 0.880 1.000 1.000 284 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), PDE1A(3), PDE1B(3), PLCB1(3), PLCB2(1), PRL(2), VIP(2) 3016367 21 20 21 9 8 4 5 1 3 0 0.740 1.000 1.000 285 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT4(3), AGPAT6(1), AGPS(4), ENPP6(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3) 6522519 36 32 34 9 10 12 5 2 7 0 0.306 1.000 1.000 286 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(3), CASP9(1), DAXX(3), FASLG(1), HSPB2(1), MAPKAPK2(1) 3069836 11 10 11 8 3 2 2 1 3 0 0.959 1.000 1.000 287 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(6), ITGAM(3), SELE(3), SELL(1) 2959112 14 14 13 9 3 6 1 1 3 0 0.906 1.000 1.000 288 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), RFK(1), TYR(3) 4151358 27 24 26 9 2 13 4 2 6 0 0.673 1.000 1.000 289 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(3), CSF1(1), FCGR3A(1), IL1B(3), IL6R(1), SELL(1), SPN(1), TGFB2(1), TNFRSF1B(1), TNFRSF8(5) 3828853 18 16 18 6 4 6 3 1 4 0 0.415 1.000 1.000 290 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9) 3044520 19 18 19 8 1 12 2 1 3 0 0.619 1.000 1.000 291 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(5), CREBBP(13), EP300(12), IKBKB(2), IL1B(3), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NR3C1(1), TGFBR1(2), TLR2(5) 7726221 50 40 49 10 8 15 8 4 15 0 0.201 1.000 1.000 292 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(5), ERBB3(6), NRG1(8), UBE2D1(1) 2803358 24 22 23 9 4 11 6 1 2 0 0.661 1.000 1.000 293 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3E(1), CXCR3(1), IFNG(1), IL12B(1), IL12RB2(5), JAK2(2), STAT4(5), TYK2(3) 4090422 21 21 21 7 3 7 3 4 4 0 0.595 1.000 1.000 294 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), JUN(1), OPRK1(2), POLR2A(3), PRKAR1B(2), PRKAR2B(3) 3486334 12 11 12 6 3 4 1 0 4 0 0.854 1.000 1.000 295 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(4), ACOX3(1), ELOVL2(2), ELOVL5(2), ELOVL6(2), FADS1(1), FADS2(2), FASN(7), HADHA(2), SCD(3) 4151496 26 20 25 9 4 10 0 3 9 0 0.579 1.000 1.000 296 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(4), BCAR1(6), ILK(2), ITGB1(1), MAPK1(1), PDK2(1), PIK3R1(5), PTK2(1), SOS1(3) 4524710 24 23 24 9 5 5 3 4 7 0 0.770 1.000 1.000 297 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH4A1(4), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), DAO(1), GAMT(1), GATM(2), GLUD1(1), MAOA(2), MAOB(3), NOS1(6), NOS3(5), OAT(3), ODC1(1), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(2), RARS(4) 12237731 89 67 89 17 26 26 9 8 20 0 0.0149 1.000 1.000 298 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2) 2855337 10 10 10 4 4 3 1 2 0 0 0.697 1.000 1.000 299 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL6(1), IL6R(1), IL6ST(5), JAK1(3), JAK2(2), JAK3(6), JUN(1), MAP2K1(2), PTPN11(2), RAF1(2), SOS1(3), STAT3(2) 6652040 35 32 35 9 11 10 4 6 4 0 0.278 1.000 1.000 300 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(3), JAK2(2), JAK3(6), SOCS3(1), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), TYK2(3) 5227685 31 26 30 9 10 7 3 4 7 0 0.373 1.000 1.000 301 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL16(3), IL3(2), IL6(1) 2684908 12 8 12 5 3 5 1 2 1 0 0.609 1.000 1.000 302 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), HK1(1), PFKL(1), PGK1(1), PKLR(3) 2579841 9 8 9 6 3 2 2 0 2 0 0.867 1.000 1.000 303 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(8), ACADL(5), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1), SUCLG1(2), SUCLG2(1) 9053586 54 44 53 11 13 18 7 3 13 0 0.177 1.000 1.000 304 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD2(1), CD33(2), CD5(2), CD7(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL3(2), ITGAX(2), TLR2(5), TLR4(6), TLR7(1) 4935203 28 23 28 9 4 10 8 1 5 0 0.473 1.000 1.000 305 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(22), ATR(5), BRCA1(6), CCNB1(1), CDC25A(3), CDC25B(2), CDKN1A(2), CDKN2D(1), CHEK1(1), CHEK2(3), EP300(12), MDM2(2), MYT1(4), PRKDC(14), RPS6KA1(1), WEE1(1), YWHAQ(1) 11611596 81 58 81 16 8 32 10 11 20 0 0.143 1.000 1.000 306 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCRL(1), CD97(3), CRHR1(2), ELTD1(4), EMR1(7), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(9), LPHN3(9) 7493484 47 39 45 10 7 16 11 4 9 0 0.0695 1.000 1.000 307 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(2), GNE(1), HK1(1), HK2(3), HK3(2), RENBP(2), UAP1(1) 4695914 14 14 14 4 5 5 0 1 3 0 0.450 1.000 1.000 308 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), JUN(1), KEAP1(6), MAPK1(1), MAPK14(1), MAPK8(1), PRKCA(1) 2266044 12 12 12 5 5 2 3 1 1 0 0.692 1.000 1.000 309 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), KMO(1), KYNU(2), MAOA(2), MAOB(3), SDS(1), TDO2(1), TPH1(2), WARS(1), WARS2(2) 15254187 96 69 96 18 27 35 5 12 17 0 0.00893 1.000 1.000 310 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), JAK1(3), JAK3(6), JUN(1), LCK(1), MAP2K1(2), MAPK8(1), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 6605526 35 27 35 8 11 8 4 7 5 0 0.228 1.000 1.000 311 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(4), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), E2F1(2), HRAS(1), MAPK1(1), NFKB1(2), PAK1(2), PIK3R1(5), RAC1(1), RAF1(2), RB1(8), TFDP1(1) 5003848 37 32 37 10 3 8 3 5 18 0 0.487 1.000 1.000 312 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ACAT1(3), ACAT2(1), ACYP1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PDHA2(5), PKLR(3) 10065443 60 49 60 12 15 25 7 3 10 0 0.0572 1.000 1.000 313 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(1), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MPL(2), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), THPO(2) 7633216 47 35 47 10 12 16 3 4 12 0 0.188 1.000 1.000 314 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), NGFR(2), RAF1(2) 2324362 15 15 15 7 7 5 2 1 0 0 0.610 1.000 1.000 315 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), RAC1(1), WASF1(3), WASL(2) 2270085 8 8 8 5 2 1 1 3 1 0 0.937 1.000 1.000 316 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(5), MAPK14(1), MAPK8(1), NFKB1(2), TNFSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1) 4059716 16 14 16 5 2 6 1 2 5 0 0.701 1.000 1.000 317 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 21 COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), F10(2), F11(4), F12(2), F2(4), F2R(4), F5(4), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), PROC(1), PROS1(5) 11920275 72 54 71 13 14 28 9 9 12 0 0.0586 1.000 1.000 318 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(3), ARRB2(1), CALM3(1), CAMK2A(3), CAMK2B(2), CLCA2(4), CLCA4(2), CNGA3(4), CNGA4(1), CNGB1(2), GNAL(2), GUCA1A(1), GUCA1B(2), GUCA1C(2), PDE1C(3), PRKACA(3), PRKG1(3), PRKG2(5) 8420096 47 41 47 10 10 16 12 1 8 0 0.106 1.000 1.000 319 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), NCK1(1), NCKAP1(4), NTRK1(5), PIR(2), PSMA7(1), RAC1(1), WASF1(3), WASF2(3), WASF3(3), WASL(2) 4259659 27 25 27 9 8 5 3 6 5 0 0.674 1.000 1.000 320 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(4), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), CASP6(1), CASP7(1), CASP9(1), EIF2S1(1), PRKCA(1), PTK2(1), PXN(3), STAT1(3), TLN1(7) 7280425 52 44 52 12 13 19 7 4 9 0 0.142 1.000 1.000 321 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(1), MAP3K1(8), MYLK(6), PAK1(2), PDGFRA(4), PIK3R1(5), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(2), TRIO(4), VAV1(8), WASF1(3) 8958219 53 45 52 12 10 12 9 5 17 0 0.223 1.000 1.000 322 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(1), CALM3(1), CD79A(2), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK14(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), RAC1(1), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8) 10386054 73 55 73 15 21 22 8 6 16 0 0.0604 1.000 1.000 323 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(2), ENDOG(1), HMGB1(1), HMGB2(1), TOP2A(7), TOP2B(8) 2919291 22 20 22 8 5 13 2 1 1 0 0.783 1.000 1.000 324 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(22), ATR(5), BRCA1(6), BRCA2(9), CHEK1(1), CHEK2(3), FANCA(5), FANCC(2), FANCD2(4), FANCF(1), FANCG(1), MRE11A(2), RAD17(4), RAD50(3), RAD51(3), TREX1(1) 11651152 72 56 70 13 7 24 12 10 19 0 0.156 1.000 1.000 325 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS3(2), DHRSX(1), HEMK1(1), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1) 4060680 16 14 16 5 3 6 1 1 5 0 0.589 1.000 1.000 326 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(2), HEMK1(1), LCMT1(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), METTL2B(1), PAPSS2(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SCLY(2), SEPHS1(3), SEPHS2(2) 6934007 31 24 31 7 7 11 3 4 6 0 0.173 1.000 1.000 327 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), CSF3(2), HLA-DRB1(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL3(2), IL6(1), PDGFA(2), TGFB2(1), TGFB3(2) 3721512 18 16 18 8 4 6 2 2 4 0 0.819 1.000 1.000 328 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(3), PPARA(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3) 5740051 29 27 29 9 11 8 1 1 8 0 0.361 1.000 1.000 329 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(9), DDX20(1), E2F1(2), ETS1(1), ETV3(3), FOS(1), HDAC5(2), HRAS(1), JUN(1), NCOR2(12), RBL1(2), RBL2(4), SIN3A(5), SIN3B(3) 7486294 48 41 48 11 10 18 5 5 10 0 0.185 1.000 1.000 330 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(1), GTF2F1(5), GTF2H1(1), GTF2H3(1), GTF2I(2), GTF2IRD1(6), STON1(3), TAF1(5), TAF10(1), TAF1L(8), TAF2(5), TAF4(2), TAF4B(3), TAF5(2), TAF5L(5), TAF6(1), TAF6L(2), TAF7(1), TAF7L(2), TAF9B(1), TBPL1(1), TBPL2(2) 9865842 62 53 62 14 10 21 14 9 8 0 0.154 1.000 1.000 331 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), C1GALT1(1), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GCNT1(3), GCNT3(1), GCNT4(4), OGT(3), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(2), WBSCR17(10) 8858614 62 54 62 15 16 15 14 9 8 0 0.175 1.000 1.000 332 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), GCK(1), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(2), PFKFB4(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1) 6640440 35 28 35 9 10 13 2 3 7 0 0.195 1.000 1.000 333 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3) 3740337 14 14 13 6 4 5 1 1 3 0 0.768 1.000 1.000 334 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(1), GCLC(1), GCLM(1), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), PGD(1) 5094863 14 14 14 4 2 8 1 2 1 0 0.429 1.000 1.000 335 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(4), B3GNT2(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST1(1), CHST6(2), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1) 3305825 24 22 24 9 6 8 5 4 1 0 0.599 1.000 1.000 336 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), XYLB(1) 7374600 24 23 24 5 5 10 3 3 3 0 0.214 1.000 1.000 337 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME3(1), PGK1(1), PGK2(1), PKLR(3), RPE(1), RPIA(1), TKT(1), TKTL1(1) 5417427 28 25 28 9 7 10 1 3 7 0 0.514 1.000 1.000 338 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACSS1(2), ACSS2(8), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(4), LDHAL6A(3), LDHAL6B(1), MCEE(1), MUT(3), PCCA(3), PCCB(1), SUCLG1(2), SUCLG2(1) 10835069 67 54 66 15 15 28 5 7 12 0 0.143 1.000 1.000 339 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BIRC2(1), BIRC3(2), CASP8(6), CFLAR(2), FADD(1), JUN(1), MAP2K4(3), MAP3K3(1), MAP3K7(3), NFKB1(2), NFKB2(2), NR2C2(4), RALBP1(2), RIPK1(2), TNFAIP3(5), TNFRSF1B(1), TRAF2(1) 7723449 39 30 38 9 9 11 2 7 10 0 0.213 1.000 1.000 340 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(2), JAK3(6), MAPK1(1), STAT3(2), TYK2(3) 3333906 17 17 17 7 4 3 4 4 2 0 0.803 1.000 1.000 341 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), BDH1(1), BDH2(4), DDHD1(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADH(1), HADHA(2), HMGCS2(2), HSD17B4(4), HSD3B7(2), ILVBL(1), L2HGDH(3), OXCT2(1), PDHA2(5), PLA1A(1), PPME1(1), PRDX6(3), RDH13(1) 11194529 67 51 67 14 12 31 4 7 13 0 0.0635 1.000 1.000 342 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACOT12(2), ACSS1(2), ACSS2(8), ACYP1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6A(3), LDHAL6B(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PCK2(2), PDHA2(5), PKLR(3) 12696780 80 61 80 17 18 36 7 7 12 0 0.0350 1.000 1.000 343 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(4), BCL2L1(1), CASP9(1), CHUK(5), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(2), NFKB1(2), PIK3R1(5), RAC1(1), RAF1(2), RALA(1), RALBP1(2), RHOA(3) 4852702 33 27 33 10 7 9 6 2 9 0 0.494 1.000 1.000 344 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(5), ASRGL1(2), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), HAL(1) 5799709 40 32 40 11 3 15 7 7 8 0 0.424 1.000 1.000 345 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(2), EPOR(2), HIF1A(5), JAK2(2), NFKB1(2) 3532655 13 13 13 6 2 6 0 3 2 0 0.810 1.000 1.000 346 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), IDUA(1), LCT(8), NAGLU(3) 4024338 21 18 21 8 5 6 4 3 3 0 0.727 1.000 1.000 347 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), RIPK1(2), TANK(3), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1) 6170506 38 31 38 10 8 8 5 8 9 0 0.485 1.000 1.000 348 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), ESCO1(3), ESCO2(1), LPO(3), MAOA(2), MAOB(3), MIF(1), MPO(3), PRDX6(3), SH3GLB1(2), TAT(2), TPO(8) 9280965 49 42 49 11 16 10 3 6 14 0 0.105 1.000 1.000 349 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(5), AKT1(4), BAX(2), BCL2L1(1), CSF2RB(6), IGF1(1), IGF1R(4), IL3(2), IL3RA(1), KIT(7), KITLG(2), PIK3R1(5), PRKAR1B(2), PRKAR2B(3) 5434747 45 37 45 14 9 10 9 5 12 0 0.531 1.000 1.000 350 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), ALDOC(4), FBP2(2), H6PD(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1) 5514466 26 24 26 8 5 13 2 3 3 0 0.408 1.000 1.000 351 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AOC2(4), AOC3(5), ASPA(2), DDC(2), HAL(1), HARS(1), HDC(2), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(2) 6689348 46 38 46 13 14 11 5 8 8 0 0.318 1.000 1.000 352 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(4), AKT2(1), AKT3(2), GSK3A(2), GSK3B(3), IL4R(3), IRS1(6), IRS2(3), JAK1(3), JAK3(6), MAPK1(1), PIK3CD(5), PIK3R1(5), PPP1R13B(4), RAF1(2), SOS1(3), SOS2(1), STAT6(3) 9439254 57 47 57 13 13 12 8 9 15 0 0.218 1.000 1.000 353 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(4), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCAT2(2), BCKDHA(2), BCKDHB(3), DBT(2), DLD(4), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HIBCH(4), HMGCS2(2), HSD17B4(4), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), OXCT2(1), PCCA(3), PCCB(1) 11874394 69 55 69 15 10 37 5 2 15 0 0.153 1.000 1.000 354 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(4), HLA-A(1), ITGB1(1), KLRC3(1), KLRC4(1), KLRD1(2), MAP2K1(2), PAK1(2), PIK3R1(5), PTK2B(4), RAC1(1), SYK(2), VAV1(8) 4623267 34 26 34 10 6 7 1 6 14 0 0.614 1.000 1.000 355 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), HRAS(1), JUN(1), MAP2K1(2), MAPK1(1), NFKB1(2), PLCB1(3), PRKCA(1), RAF1(2) 4229590 14 14 14 9 3 5 2 1 3 0 0.941 1.000 1.000 356 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1) 6344405 38 30 38 10 11 10 5 1 11 0 0.350 1.000 1.000 357 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(5), MAP2K1(2), MAP3K1(8), MAPK14(1), NCOR2(12), THRA(6), THRB(1) 4838135 39 31 39 12 12 14 4 2 7 0 0.414 1.000 1.000 358 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(5), EPRS(3), GARS(3), HARS(1), IARS(4), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), QARS(3), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(2), YARS(1) 8665429 50 41 50 12 12 20 6 7 5 0 0.208 1.000 1.000 359 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(1), RPL10L(5), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(1), RPL6(1), RPL8(2), RPS10(1), RPS11(2), RPS13(2), RPS24(1), RPS26(2), RPS5(2), RPS9(1) 6461598 39 30 39 9 9 10 5 7 8 0 0.391 1.000 1.000 360 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(5), AASS(3), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADHA(2), PLOD1(3), PLOD2(3), PLOD3(4), SDS(1), SHMT1(2), SHMT2(2), TMLHE(1) 10130832 70 55 70 17 15 31 8 3 13 0 0.131 1.000 1.000 361 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(22), ATR(5), BAI1(6), BAX(2), BID(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), CHEK1(1), CHEK2(3), DDB2(1), EI24(1), GADD45B(2), GTSE1(2), IGF1(1), IGFBP3(2), MDM2(2), MDM4(1), PERP(2), PMAIP1(1), PPM1D(2), RCHY1(3), RFWD2(1), RRM2B(1), SERPINB5(2), SESN2(3), SESN3(1), STEAP3(4), THBS1(2), TNFRSF10B(1), TP73(3), TSC2(7) 17474296 108 75 108 19 22 30 12 12 32 0 0.00511 1.000 1.000 362 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), AMT(1), ATIC(2), FTCD(2), GART(2), MTFMT(1), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2) 5220380 35 31 35 11 4 12 8 5 6 0 0.553 1.000 1.000 363 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(3), PRPS2(2), SRM(3) 3588424 16 12 16 6 7 2 2 2 3 0 0.670 1.000 1.000 364 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(1), BIN1(1), CALM3(1), DNM1(4), EPN1(4), EPS15(3), PICALM(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYNJ1(7), SYNJ2(4), SYT1(3) 6288611 39 35 39 11 8 12 3 2 13 1 0.389 1.000 1.000 365 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(4), AKT2(1), AKT3(2), IARS(4), IL13RA1(1), IL2RG(3), IL4R(3), INPP5D(4), JAK1(3), JAK2(2), JAK3(6), NR0B2(1), PPP1R13B(4), SERPINA4(4), SOS1(3), SOS2(1), STAT6(3), TYK2(3) 9622377 52 45 52 11 13 11 7 13 8 0 0.154 1.000 1.000 366 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(5), AKT1(4), CAMK2A(3), CAMK2B(2), GNAS(16), HRAS(1), MAPK1(1), MAPK14(1), PIK3R1(5), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(4), SOS1(3) 7435410 53 45 53 13 18 13 4 7 11 0 0.266 1.000 1.000 367 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(1), GCLC(1), GCLM(1), GPX7(1), GSR(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), OPLAH(3) 6208281 23 23 23 6 5 10 1 4 3 0 0.350 1.000 1.000 368 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 CASP2(2), CHUK(5), CRADD(1), IKBKB(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP4K2(4), MAPK14(1), MAPK8(1), NFKB1(2), RIPK1(2), TANK(3), TRAF2(1) 6736502 36 32 36 10 6 10 6 5 9 0 0.514 1.000 1.000 369 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12(2), ALOX12B(4), ALOX15(2), ALOX15B(2), ALOX5(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP2U1(2), CYP4A22(2), CYP4F2(4), CYP4F3(1), DHRS4(2), EPHX2(2), GPX7(1), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2) 11142820 61 45 61 13 22 22 4 4 9 0 0.0343 1.000 1.000 370 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4) 5545815 36 30 36 11 7 18 5 1 5 0 0.395 1.000 1.000 371 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREBBP(13), EP300(12), NCOA3(3), PRKAR1B(2), PRKAR2B(3) 5579274 35 28 35 11 5 13 3 1 13 0 0.664 1.000 1.000 372 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM3(1), ELK1(2), FOS(1), GNAI1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAF1(2), SYT1(3) 9508983 70 57 70 17 23 22 7 4 14 0 0.118 1.000 1.000 373 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(16), GNGT1(1), PPP2CA(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAR1B(2), PRKAR2B(3) 4211293 37 35 37 11 11 11 5 3 7 0 0.523 1.000 1.000 374 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), CHUK(5), ELK1(2), FOS(1), IKBKB(2), IRAK1(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), PPARA(1), TLR10(3), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TOLLIP(1), TRAF6(1) 9938613 53 46 52 13 5 14 13 7 14 0 0.341 1.000 1.000 375 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR2(2), CMA1(1), COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), REN(2) 7056935 38 33 38 11 8 18 3 4 5 0 0.511 1.000 1.000 376 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), BTRC(3), CDC20(3), CDC23(1), CDC26(1), CDC27(7), CUL1(4), CUL2(1), CUL3(3), FZR1(4), ITCH(3), SMURF1(2), SMURF2(2), UBA1(4), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), WWP1(6), WWP2(3) 10702841 67 50 67 16 8 25 4 11 18 1 0.351 1.000 1.000 377 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 59 AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CDK2(1), CREB5(2), F2RL2(1), GAB1(1), GSK3A(2), GSK3B(3), IFI27(2), IGF1(1), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), MET(4), NOLC1(4), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARD3(7), PARD6A(1), PIK3CD(5), PPP1R13B(4), PREX1(5), PTK2(1), PTPN1(5), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TSC1(10), TSC2(7), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 19397095 117 75 117 23 28 33 13 16 27 0 0.00706 1.000 1.000 378 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(3), ATG7(4), BECN1(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNG(1), PIK3C3(1), PRKAA1(2), PRKAA2(1), ULK1(3), ULK2(2), ULK3(3) 5863242 25 23 25 9 4 10 4 3 4 0 0.746 1.000 1.000 379 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX15(2), ALOX5(4), CYP4F2(4), CYP4F3(1), EPX(2), LPO(3), LTA4H(1), MPO(3), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PRDX1(2), PRDX2(1), PRDX6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2), TPO(8) 7948482 52 43 52 14 20 15 5 3 9 0 0.156 1.000 1.000 380 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACAT2(1), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), FN3K(2), GCDH(1), HADHA(2), SH3GLB1(2), YOD1(1) 6940979 24 23 24 7 3 12 2 0 7 0 0.627 1.000 1.000 381 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(2), ANXA5(3), ANXA6(1), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(1), HSD11B2(1), PLA2G4A(1), PRL(2), PTGDS(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), PTGIS(2), PTGS1(2), TBXAS1(2) 5619371 33 27 33 10 9 11 4 4 5 0 0.459 1.000 1.000 382 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(4), F12(2), F13B(3), F2(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), LPA(10), PLAT(1), PLG(3), SERPINB2(2), SERPINF2(2), VWF(9) 9584006 63 49 62 16 14 21 10 3 15 0 0.272 1.000 1.000 383 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(4), AVP(1), CABIN1(8), CALM3(1), CAMK1(1), CAMK1G(2), HDAC5(2), IGF1(1), IGF1R(4), INSR(9), MAPK14(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1), NFATC1(4), NFATC2(6), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3) 8942110 66 53 65 19 22 15 7 3 19 0 0.218 1.000 1.000 384 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), P4HB(2), SLC23A1(1), SLC23A2(4), SLC2A1(1), SLC2A3(1) 7089803 38 31 38 12 7 17 4 5 5 0 0.528 1.000 1.000 385 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(6), MAPK1(1), MAPK14(1), MKNK1(1), PABPC1(2), PDK2(1), PIK3R1(5), PRKCA(1) 6923149 39 32 39 11 5 9 6 1 18 0 0.557 1.000 1.000 386 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(6), EGF(4), EGFR(5), HRAS(1), MAP2K1(2), MAPK1(1), PTPRB(2), RAF1(2), RASA1(9), SOS1(3), SPRY4(2) 6892034 37 30 37 11 6 15 5 6 5 0 0.523 1.000 1.000 387 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), SOAT2(1) 6362072 40 33 40 14 13 10 5 3 9 0 0.549 1.000 1.000 388 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTAP(2), MTFMT(1), MTR(7), SRM(3), TAT(2) 5743274 35 28 35 11 8 11 2 6 8 0 0.470 1.000 1.000 389 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), BHMT(3), CHDH(1), CHKB(1), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), HSD3B7(2), MAOA(2), MAOB(3), PHGDH(1), PIPOX(1), PISD(1), PSAT1(3), PSPH(2), RDH13(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT1(2), SHMT2(2), TARS(6), TARS2(2) 12051986 67 49 67 16 15 30 6 7 9 0 0.0674 1.000 1.000 390 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(6), CARM1(2), CCND1(1), CREBBP(13), EP300(12), ERCC3(1), ESR1(6), GRIP1(4), GTF2E1(1), GTF2F1(5), HDAC1(1), HDAC3(3), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(12), NR0B1(1), NRIP1(3), PELP1(3), POLR2A(3), TBP(2) 12221863 86 62 86 23 18 32 8 5 23 0 0.230 1.000 1.000 391 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(6), EEF1A2(1), EEF1G(1), EEF2(5), EEF2K(4), EIF1AY(1), EIF2AK1(2), EIF2AK3(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G3(4), EIF5B(6), PABPC1(2), PABPC3(5), PAIP1(1) 12183337 60 49 59 14 9 19 7 9 16 0 0.214 1.000 1.000 392 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), PON1(1) 8200350 47 39 47 13 10 18 4 6 9 0 0.232 1.000 1.000 393 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(4), AKT2(1), AKT3(2), ANKRD6(2), APC(15), AXIN1(2), AXIN2(2), CER1(1), CSNK1A1(2), CTNNB1(9), DACT1(2), DKK2(3), DKK3(1), DKK4(2), FRAT1(1), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(8), MVP(3), NKD2(5), PSEN1(2), PTPRA(4), SENP2(3), SFRP1(2), TSHB(2), WIF1(2) 11232811 88 65 85 23 20 26 11 9 21 1 0.239 1.000 1.000 394 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(3), ACAT2(1), AFMID(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CARM1(2), CYP1A1(3), CYP1A2(1), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HEMK1(1), HSD17B4(4), KMO(1), KYNU(2), LCMT1(1), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(3), OGDH(2), OGDHL(6), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(1), WARS2(2) 16676454 91 65 91 20 29 36 2 10 14 0 0.0296 1.000 1.000 395 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(5), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUL(2), HAL(1) 5202756 34 27 34 11 1 12 7 7 7 0 0.653 1.000 1.000 396 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MIOX(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CB(4), PIK3CG(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3) 11907837 62 47 62 14 12 30 3 6 11 0 0.0921 1.000 1.000 397 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), ATP6V0C(1), BHMT(3), CHDH(1), CHKB(1), CPT1B(6), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), MAOA(2), MAOB(3), PISD(1), PLCB2(1), PLCG1(5), PLCG2(3), PSPH(2), SARDH(2), SARS(2), SHMT1(2), SHMT2(2), TARS(6) 11752292 71 53 70 17 18 31 6 5 11 0 0.0608 1.000 1.000 398 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(2), ENPP1(5), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5C1A(1), NT5C1B(2), NT5M(1), NUDT12(1) 5925817 33 29 33 11 3 17 0 6 7 0 0.648 1.000 1.000 399 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BTRC(3), CSNK1A1(2), CSNK1A1L(1), CSNK1D(1), CSNK1E(1), CSNK1G2(1), GAS1(2), GLI1(5), GLI2(5), GLI3(9), GSK3B(3), HHIP(4), IHH(2), LRP2(20), PRKACA(3), PTCH1(13), PTCH2(4), SMO(4), STK36(3), SUFU(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(3) 16379553 116 73 115 28 30 34 12 15 25 0 0.0834 1.000 1.000 400 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM3(1), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK14(1), MAPK8(1), PAK1(2), PLCG1(5), PRKCA(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3) 7874496 50 46 50 15 14 14 5 7 10 0 0.431 1.000 1.000 401 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(1), APC(15), AXIN1(2), BMP10(1), BMP2(1), BMP5(1), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(5), CTNNB1(9), FZD1(4), GSK3B(3), MAP3K7(3), MEF2C(2), NKX2-5(3), NOG(1), RFC1(5), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR3(3), WNT1(1) 9517432 71 54 69 21 11 19 13 9 18 1 0.612 1.000 1.000 402 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACADVL(2), ACAT1(3), ACAT2(1), ACOX1(4), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP4A22(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(4) 13373244 74 57 73 19 21 32 2 3 16 0 0.150 1.000 1.000 403 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(1), AKT1(4), AKT2(1), AKT3(2), BTK(1), DAPP1(1), GSK3A(2), GSK3B(3), IARS(4), INPP5D(4), PPP1R13B(4), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 8897455 40 35 40 11 8 14 6 5 7 0 0.360 1.000 1.000 404 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), CREB5(2), DUSP10(3), EEF2K(4), ELK1(2), IL1R1(1), MAP2K4(3), MAP3K10(4), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(2), NFKB1(2), NR2C2(4), TRAF6(1) 9368323 58 40 56 16 20 17 6 5 10 0 0.206 1.000 1.000 405 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1) 14498774 92 62 91 22 20 30 25 6 11 0 0.0659 1.000 1.000 406 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1) 14498774 92 62 91 22 20 30 25 6 11 0 0.0659 1.000 1.000 407 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(5), FADD(1), IKBKB(2), IL1R1(1), IRAK1(2), MAP3K1(8), MAP3K7(3), NFKB1(2), RIPK1(2), TLR4(6), TNFAIP3(5), TNFRSF1B(1), TRAF6(1) 6681831 39 33 38 13 8 7 9 6 9 0 0.709 1.000 1.000 408 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), ALDOC(4), DERA(2), FBP2(2), H6PD(1), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1), TKTL1(1) 6668314 30 27 30 10 6 13 2 6 3 0 0.519 1.000 1.000 409 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS2(2), BLVRA(3), CP(3), CPOX(1), EARS2(1), EPRS(3), FECH(1), FTH1(2), FTMT(2), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), MMAB(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UROD(1), UROS(1) 11416315 49 39 49 12 12 18 6 6 7 0 0.181 1.000 1.000 410 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG5(2), ALG6(2), ALG9(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), DDOST(1), FUT8(2), GANAB(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), RFT1(1), RPN1(3), RPN2(3), STT3B(5) 11728759 66 51 66 18 11 24 10 6 15 0 0.316 1.000 1.000 411 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(1), EXTL3(3), GLCE(3), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), NDST1(5), NDST2(5), NDST3(5), NDST4(6) 5708978 45 38 45 15 12 14 8 7 4 0 0.467 1.000 1.000 412 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(4), DLD(4), DUSP10(3), DUSP4(1), GAB1(1), GCK(1), IL1R1(1), JUN(1), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(1), MAPK9(2), MYEF2(2), NFATC3(2), NR2C2(4), PAPPA(6), TRAF6(1), ZAK(4) 13476292 89 59 88 22 20 28 8 11 22 0 0.201 1.000 1.000 413 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(2), CASP8(6), CRADD(1), DFFA(1), DFFB(2), FADD(1), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MADD(7), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), RB1(8), RIPK1(2), SPTAN1(8), TRAF2(1) 10935795 80 53 79 22 13 19 8 14 26 0 0.588 1.000 1.000 414 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), FUCA2(3), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NAGLU(3), NEU1(1), NEU2(2), NEU4(4), SPAM1(1) 9599067 58 46 58 17 11 25 7 6 9 0 0.285 1.000 1.000 415 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(4), AP2A1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), GSK3A(2), GSK3B(3), LYN(2), PFKL(1), PFKM(4), PFKP(2), PLCG1(5), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1) 7053156 36 31 36 11 12 11 6 1 6 0 0.405 1.000 1.000 416 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(1), GHR(2), HRAS(1), INSR(9), IRS1(6), JAK2(2), MAP2K1(2), MAPK1(1), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RPS6KA1(1), SOS1(3), STAT5A(3), STAT5B(2) 8484733 46 42 46 14 13 12 6 5 10 0 0.490 1.000 1.000 417 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT2(2), B3GALT4(1), B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALNT1(3), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT6(3), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGZ(1), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1) 13370806 75 62 75 20 19 26 10 13 7 0 0.145 1.000 1.000 418 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CALR(2), CANX(1), CD74(1), CIITA(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA16(1), IFNA2(1), IFNA7(1), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRC4(1), KLRD1(2), NFYA(1), NFYB(2), NFYC(1), PDIA3(2), PSME1(1), PSME2(3), RFX5(5), RFXANK(1), RFXAP(2), TAP2(1), TAPBP(1) 12928229 82 54 82 23 14 24 13 9 22 0 0.401 1.000 1.000 419 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(22), CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDKN1A(2), CDKN1C(1), CDKN2C(1), CDKN2D(1), CREB3L1(2), CREB3L4(1), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), GBA2(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MNAT1(1), MYT1(4), NACA(7), POLA2(2), POLE(8), POLE2(1), PRIM1(4), RB1(8), RBL1(2), RPA1(3), TFDP1(1), TFDP2(4), TNXB(14), WEE1(1) 20920642 121 78 121 27 24 39 12 19 27 0 0.0614 1.000 1.000 420 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(4), AKT2(1), AKT3(2), BRAF(4), EIF4EBP1(1), HIF1A(5), IGF1(1), MAPK1(1), PGF(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRKAA1(2), PRKAA2(1), RHEB(1), RICTOR(6), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), STK11(5), TSC1(10), TSC2(7), ULK1(3), ULK2(2), ULK3(3), VEGFC(5) 14195285 94 67 94 24 18 28 14 9 24 1 0.157 1.000 1.000 421 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT4(3), AGPS(4), CDS1(1), CDS2(1), CHAT(8), CHKB(1), CPT1B(6), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD2(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB2(1), PLCG1(5), PLCG2(3), PPAP2A(2), PPAP2B(3) 14001037 80 60 79 21 28 28 5 6 13 0 0.0944 1.000 1.000 422 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), FADD(1), FASLG(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MCL1(1), MDM2(2), NFKB1(2), PARP1(2), PRF1(4), RIPK1(2), TNFRSF1B(1), TNFSF10(1), TRAF1(2), TRAF2(1) 10059817 57 45 57 17 13 15 8 6 15 0 0.509 1.000 1.000 423 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(3), CMAS(1), CTBS(1), CYB5R1(1), GFPT1(2), GFPT2(3), GNE(1), HK1(1), HK2(3), HK3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), NAGK(2), NANS(3), NPL(1), RENBP(2), UAP1(1) 7946896 35 27 34 11 6 16 2 3 8 0 0.468 1.000 1.000 424 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(1), CDK2(1), CDT1(1), DIAPH2(8), MCM10(2), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), NACA(7), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), PRIM1(4), RFC1(5), RFC3(3), RFC4(1), RFC5(1), RPA1(3), RPA4(3) 13848527 74 52 74 19 10 29 9 14 12 0 0.254 1.000 1.000 425 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(4), AKT2(1), AKT3(2), CASP9(1), HRAS(1), KDR(5), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NOS3(5), NRAS(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PRKCG(2), PTK2(1), PXN(3), RAC1(1), RAF1(2), SH2D2A(1), SPHK2(3) 19443647 113 79 112 25 32 44 10 9 18 0 0.0141 1.000 1.000 426 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ADAM17(3), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), CCL5(1), CHUK(5), CSK(2), CXCL1(1), EGFR(5), IKBKB(2), JAM3(1), JUN(1), LYN(2), MAP2K4(3), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(5), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), TCIRG1(1), TJP1(6) 19415392 93 70 93 21 18 30 13 15 17 0 0.100 1.000 1.000 427 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(1), CRK(1), DOCK1(9), ELK1(2), FOS(1), GAB1(1), HGF(2), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), MET(4), PAK1(2), PIK3R1(5), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAF1(2), RAP1A(1), RASA1(9), SOS1(3), STAT3(2) 11711557 68 52 68 20 13 30 5 6 14 0 0.380 1.000 1.000 428 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(2), ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), C5AR1(1), CALCRL(1), CCKAR(1), CCKBR(3), CHRM1(2), CHRM3(5), CHRM4(2), CHRM5(1), CNR1(3), CNR2(1), CRHR1(2), CYSLTR1(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2(4), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GABBR1(2), GABBR2(3), GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GABRB1(7), GABRB2(1), GABRB3(4), GABRE(3), GABRG1(5), GABRG2(4), GABRG3(2), GABRP(1), GABRR2(1), GALR1(2), GALR2(3), GALR3(1), GH1(1), GH2(2), GHR(2), GHRHR(2), GHSR(2), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(2), GLRA3(1), GLRB(6), GPR156(2), GPR50(1), GPR63(3), GPR83(5), GRIA1(9), GRIA2(8), GRIA3(5), GRIA4(10), GRID1(7), GRID2(7), GRIK1(4), GRIK2(4), GRIK3(7), GRIK4(10), GRIK5(2), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRIN3A(3), GRIN3B(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM6(3), GRM7(3), GRM8(11), GRPR(1), GZMA(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HRH4(2), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LEPR(4), LHCGR(6), MAS1(1), MC1R(2), MC2R(1), MC3R(1), MC4R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPBWR1(6), NPBWR2(5), NPFFR1(1), NPFFR2(2), NPY1R(1), NPY2R(1), NPY5R(1), NR3C1(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(7), PRL(2), PRLHR(2), PRLR(3), PRSS1(3), PRSS3(1), PTGER2(1), PTGER3(1), PTGER4(3), PTGFR(1), PTGIR(2), PTH2R(2), RXFP1(5), RXFP2(6), SSTR1(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR2(1), TAAR5(2), TAAR6(1), TAAR8(1), TACR3(3), TBXA2R(2), THRA(6), THRB(1), TRPV1(3), TSHB(2), TSHR(3), TSPO(1) 59333721 523 171 523 177 139 171 74 54 85 0 0.0757 1.000 1.000 429 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), ARHGAP5(8), BCAR1(6), BIRC2(1), BIRC3(2), BRAF(4), CAPN2(1), CAV1(1), CCND1(1), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), CRK(1), CTNNB1(9), DIAPH1(2), DOCK1(9), EGF(4), EGFR(5), ELK1(2), ERBB2(12), FARP2(3), FLNA(3), FLNB(4), FLNC(10), FLT1(7), FN1(7), FYN(1), GSK3B(3), HGF(2), HRAS(1), IBSP(5), IGF1(1), IGF1R(4), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), JUN(1), KDR(5), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), MAP2K1(2), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MET(4), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARVA(2), PARVB(1), PARVG(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PGF(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(1), PRKCG(2), PTK2(1), PXN(3), RAC1(1), RAF1(2), RAP1A(1), RAPGEF1(4), RELN(17), RHOA(3), ROCK1(2), ROCK2(4), SHC4(3), SOS1(3), SOS2(1), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TLN1(7), TLN2(11), TNC(8), TNN(7), TNR(10), TNXB(14), VAV1(8), VAV2(1), VAV3(2), VCL(8), VEGFC(5), VWF(9), ZYX(1) 102698974 672 170 662 180 186 227 81 59 119 0 0.000387 1.000 1.000 430 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(2), ACVR1C(2), AKT1(4), AKT2(1), AKT3(2), ARRB1(5), ARRB2(1), ATF4(2), BDNF(3), BRAF(4), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CACNA2D1(5), CACNA2D2(2), CACNA2D3(8), CACNA2D4(6), CACNB1(2), CACNB2(1), CACNG2(1), CACNG3(1), CACNG4(2), CACNG5(4), CACNG6(2), CACNG8(2), CD14(1), CDC25B(2), CHUK(5), CRK(1), DAXX(3), DUSP10(3), DUSP4(1), DUSP5(1), DUSP6(1), DUSP7(2), DUSP9(2), ECSIT(2), EGF(4), EGFR(5), ELK1(2), ELK4(1), FASLG(1), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FLNA(3), FLNB(4), FLNC(10), FOS(1), GADD45B(2), GNA12(1), HRAS(1), IKBKB(2), IL1B(3), IL1R1(1), IL1R2(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAPT(1), MAX(1), MEF2C(2), MKNK1(1), MKNK2(2), MRAS(1), NF1(8), NFATC2(6), NFATC4(4), NFKB1(2), NFKB2(2), NLK(4), NR4A1(1), NRAS(1), NTRK1(5), NTRK2(6), PAK1(2), PAK2(1), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PPP5C(2), PRKACA(3), PRKCA(1), PRKCG(2), PTPN7(1), PTPRR(6), RAC1(1), RAF1(2), RAP1A(1), RAPGEF2(4), RASA1(9), RASA2(2), RASGRF1(9), RASGRF2(5), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(4), SOS1(3), SOS2(1), STK4(2), STMN1(1), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1), TRAF6(1), ZAK(4) 80988736 513 167 509 155 146 149 56 54 107 1 0.0470 1.000 1.000 431 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY7(5), ADCY8(11), ADCY9(6), ADORA2A(5), ADORA2B(2), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ATP2A1(4), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), ATP2B4(7), AVPR1A(3), BST1(1), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), CCKAR(1), CCKBR(3), CD38(2), CHRM1(2), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), DRD1(3), EDNRA(1), EDNRB(3), EGFR(5), ERBB2(12), ERBB3(6), F2R(4), GNA14(1), GNA15(2), GNAL(2), GNAQ(1), GNAS(16), GRIN2A(3), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), GRPR(1), HRH1(2), HRH2(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), LHCGR(6), MYLK(6), MYLK2(1), NOS1(6), NOS3(5), NTSR1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), PDE1A(3), PDE1B(3), PDE1C(3), PDGFRA(4), PDGFRB(4), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), PTGER3(1), PTGFR(1), PTK2B(4), RYR1(13), RYR2(35), RYR3(28), SLC25A4(2), SLC25A5(2), SLC8A1(7), SLC8A2(4), SLC8A3(1), SPHK2(3), TACR3(3), TBXA2R(2), TNNC1(1), TRPC1(5), VDAC1(2), VDAC2(1) 75373405 555 161 547 169 156 202 62 51 84 0 0.00343 1.000 1.000 432 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(4), ACTN1(1), ACTN2(8), ACTN4(4), APC(15), ARAF(3), ARHGEF1(3), ARHGEF12(4), ARHGEF4(1), ARHGEF6(2), ARHGEF7(3), ARPC5(1), BAIAP2(2), BCAR1(6), BRAF(4), CD14(1), CFL1(1), CHRM1(2), CHRM3(5), CHRM4(2), CHRM5(1), CRK(1), CSK(2), CYFIP1(5), CYFIP2(8), DIAPH1(2), DIAPH2(8), DIAPH3(6), DOCK1(9), EGF(4), EGFR(5), EZR(1), F2(4), F2R(4), FGD3(2), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FN1(7), GNA12(1), GNA13(3), GSN(3), HRAS(1), IQGAP1(7), IQGAP2(2), IQGAP3(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), KRAS(3), LIMK1(1), LIMK2(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MRAS(1), MSN(7), MYH10(9), MYH14(10), MYH9(2), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), NCKAP1(4), NCKAP1L(3), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PFN4(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R12B(1), PTK2(1), PXN(3), RAC1(1), RAF1(2), RDX(6), RHOA(3), ROCK1(2), ROCK2(4), SCIN(4), SLC9A1(2), SOS1(3), SOS2(1), SSH1(1), SSH2(7), SSH3(1), TIAM1(6), TIAM2(4), VAV1(8), VAV2(1), VAV3(2), VCL(8), WASF1(3), WASF2(3), WASL(2) 76045730 493 161 485 126 129 159 69 46 90 0 0.000584 1.000 1.000 433 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), COL11A1(20), COL11A2(8), COL17A1(3), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), DSC1(1), DSC2(1), DSC3(1), DSG1(7), DSG2(6), DSG3(4), DSG4(3), FN1(7), GJA1(1), GJA10(1), GJA5(3), GJA8(2), GJB4(1), GJB5(1), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(5), ITGA6(7), ITGB4(5), KRT1(5), KRT10(4), KRT12(5), KRT13(1), KRT14(1), KRT15(3), KRT17(1), KRT18(2), KRT19(1), KRT2(1), KRT20(2), KRT23(7), KRT24(4), KRT25(3), KRT27(3), KRT28(1), KRT3(1), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT38(2), KRT39(1), KRT5(1), KRT6A(5), KRT6B(4), KRT6C(2), KRT72(3), KRT73(3), KRT74(1), KRT76(1), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(2), KRT84(2), KRT85(2), KRT9(4), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), LMNA(2), LMNB1(1), LMNB2(5), NES(8), PRPH(2), RELN(17), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VIM(2), VWF(9) 69517679 475 155 471 137 136 158 54 55 72 0 0.0172 1.000 1.000 434 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ANXA6(1), ARRB1(5), ARRB2(1), ATP1A4(3), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1S(5), CACNB1(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(2), CASQ1(1), CASQ2(1), CHRM1(2), CHRM3(5), CHRM4(2), CHRM5(1), GJA1(1), GJA5(3), GJB4(1), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), ITPR1(6), ITPR2(8), ITPR3(2), KCNB1(1), KCNJ5(2), MIB1(1), NME7(3), PKIA(1), PLCB3(4), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SLC8A3(1), USP5(5), YWHAB(1), YWHAQ(1) 53179495 363 151 357 113 100 122 40 32 68 1 0.0278 1.000 1.000 435 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD36(2), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), DAG1(1), FN1(7), FNDC1(10), FNDC3A(4), GP5(1), GP6(1), HMMR(4), HSPG2(14), IBSP(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), RELN(17), SDC2(1), SDC3(1), SDC4(1), SV2A(2), SV2C(3), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VWF(9) 62721619 420 149 414 118 120 139 44 40 77 0 0.0180 1.000 1.000 436 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM1(1), ABLIM3(1), ARHGEF12(4), CFL1(1), CXCR4(1), DCC(17), DPYSL2(1), DPYSL5(2), EFNA1(1), EFNA4(1), EFNB2(2), EFNB3(2), EPHA2(6), EPHA3(8), EPHA4(4), EPHA5(8), EPHA6(6), EPHA7(7), EPHA8(6), EPHB1(8), EPHB2(4), EPHB3(1), EPHB4(3), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(1), KRAS(3), L1CAM(4), LIMK1(1), LIMK2(3), LRRC4C(8), MAPK1(1), MET(4), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLXNA1(6), PLXNA2(12), PLXNA3(2), PLXNB1(8), PLXNB2(13), PLXNB3(5), PLXNC1(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTK2(1), RAC1(1), RASA1(9), RGS3(5), RHOA(3), RHOD(1), ROBO1(8), ROBO2(9), ROBO3(4), ROCK1(2), ROCK2(4), SEMA3A(6), SEMA3C(1), SEMA3D(5), SEMA3E(3), SEMA3F(3), SEMA3G(3), SEMA4A(1), SEMA4B(2), SEMA4C(1), SEMA4D(3), SEMA4F(3), SEMA4G(2), SEMA5A(9), SEMA5B(5), SEMA6A(4), SEMA6B(2), SEMA6C(2), SEMA6D(9), SLIT1(6), SLIT2(11), SLIT3(10), SRGAP1(2), SRGAP3(4), UNC5A(2), UNC5B(3), UNC5C(8), UNC5D(10) 54004221 407 147 402 120 84 149 59 47 68 0 0.0646 1.000 1.000 437 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), AMOTL1(3), ASH1L(5), CASK(3), CGN(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(4), EPB41L3(10), EXOC4(4), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(6), JAM3(1), KRAS(3), LLGL1(4), LLGL2(3), MAGI1(4), MAGI2(8), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(5), MRAS(1), MYH1(11), MYH10(9), MYH11(5), MYH13(11), MYH14(10), MYH15(7), MYH2(10), MYH3(9), MYH4(7), MYH6(10), MYH7(12), MYH7B(7), MYH8(3), MYH9(2), MYL7(2), MYL9(1), NRAS(1), OCLN(2), PARD3(7), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), RAB3B(1), RHOA(3), SPTAN1(8), SYMPK(4), TJAP1(1), TJP1(6), TJP2(2), TJP3(2), VAPA(1), YES1(5), ZAK(4) 53849065 361 145 358 92 93 127 52 32 57 0 0.00363 1.000 1.000 438 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(5), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADM(1), ARRB1(5), ARRB2(1), ATF4(2), ATP2A2(5), ATP2A3(3), CALM3(1), CAMK2A(3), CAMK2B(2), CNN1(1), CNN2(1), CORIN(2), CRHR1(2), DGKZ(2), FOS(1), GABPA(1), GBA2(1), GJA1(1), GNAQ(1), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), GSTO1(1), GUCA2B(2), GUCY1A3(3), IGFBP3(2), IGFBP4(1), IL1B(3), IL6(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), MIB1(1), MYL4(1), MYLK2(1), NFKB1(2), NOS1(6), NOS3(5), OXTR(1), PDE4B(3), PDE4D(6), PKIA(1), PLCB3(4), PLCG1(5), PLCG2(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RAMP1(1), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RLN1(1), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SP1(1), TNXB(14), USP5(5), YWHAB(1), YWHAQ(1) 48991189 318 143 315 87 81 112 37 31 56 1 0.00912 1.000 1.000 439 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CCL14(2), CCL16(2), CCL18(1), CCL20(2), CCL22(1), CCL28(2), CCL5(1), CCL7(1), CCL8(1), CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CD40LG(1), CLCF1(1), CNTF(1), CRLF2(1), CSF1(1), CSF1R(9), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), CX3CL1(1), CX3CR1(3), CXCL1(1), CXCL14(1), CXCL3(1), CXCL6(1), CXCR3(1), CXCR4(1), EDA2R(2), EDAR(1), EGF(4), EGFR(5), EPOR(2), FASLG(1), FLT1(7), FLT3(9), FLT3LG(1), FLT4(5), GDF5(2), GH1(1), GH2(2), GHR(2), HGF(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL15(1), IL15RA(1), IL17B(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(1), IL19(1), IL1B(3), IL1R1(1), IL1R2(2), IL1RAP(2), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), INHBA(6), INHBB(1), INHBC(1), INHBE(4), KDR(5), KIT(7), KITLG(2), LEPR(4), LIFR(3), MET(4), MPL(2), NGFR(2), OSMR(3), PDGFB(2), PDGFC(3), PDGFRA(4), PDGFRB(4), PF4(1), PF4V1(2), PLEKHO2(1), PRL(2), PRLR(3), RELT(1), TGFB2(1), TGFB3(2), TGFBR1(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF12A(1), TNFRSF18(1), TNFRSF19(2), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFRSF4(1), TNFRSF8(5), TNFRSF9(1), TNFSF10(1), TNFSF12(2), TNFSF13B(1), TNFSF14(1), TNFSF4(1), TNFSF9(2), TPO(8), TSLP(1), VEGFC(5), XCL2(1), XCR1(2) 48873824 318 141 315 104 70 98 44 40 66 0 0.308 1.000 1.000 440 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(5), ACTN2(8), ACTN4(4), DMD(19), MYBPC1(4), MYBPC2(3), MYBPC3(6), MYH3(9), MYH6(10), MYH7(12), MYH8(3), MYL1(1), MYL3(2), MYL4(1), MYL9(1), MYOM1(7), NEB(18), TMOD1(1), TNNI3(1), TNNT2(3), TPM2(1), TPM4(1), TTN(159), VIM(2) 38550052 282 136 282 83 54 103 56 37 29 3 0.303 1.000 1.000 441 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADSL(3), ADSSL1(1), AK5(3), AK7(2), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), ENTPD4(1), ENTPD5(3), ENTPD6(1), FHIT(3), GART(2), GDA(2), GMPR2(1), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NME6(1), NME7(3), NPR1(6), NPR2(4), NT5C1A(1), NT5C1B(2), NT5M(1), PAPSS2(3), PDE10A(6), PDE11A(5), PDE1A(3), PDE1C(3), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6H(2), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(4), PKLR(3), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), PRPS1(1), PRPS2(2), RFC5(1), RRM2B(1), XDH(9) 45240429 274 133 273 83 61 90 47 30 46 0 0.212 1.000 1.000 442 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(15), AXIN1(2), AXIN2(2), BTRC(3), CACYBP(2), CAMK2A(3), CAMK2B(2), CCND1(1), CER1(1), CHD8(9), CREBBP(13), CSNK1A1(2), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CSNK2A2(1), CTBP2(2), CTNNB1(9), CTNNBIP1(1), CUL1(4), CXXC4(1), DAAM1(6), DAAM2(6), DKK2(3), DKK4(2), DVL2(1), DVL3(2), EP300(12), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LRP5(4), LRP6(8), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKD2(5), NLK(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PORCN(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRICKLE1(4), PRICKLE2(2), PRKACA(3), PRKCA(1), PRKCG(2), PSEN1(2), RAC1(1), RHOA(3), ROCK1(2), ROCK2(4), SENP2(3), SFRP1(2), SFRP2(1), SFRP4(3), SMAD2(2), SMAD3(3), SOX17(3), TBL1X(2), TBL1XR1(3), TCF7L1(2), VANGL1(3), VANGL2(4), WIF1(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2) 43136459 290 132 286 71 82 88 37 28 54 1 0.0101 1.000 1.000 443 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(2), CADM1(2), CADM3(1), CD2(1), CD22(5), CD226(1), CD28(1), CD34(2), CD40LG(1), CD58(1), CD6(2), CD80(1), CD86(1), CDH1(1), CDH15(1), CDH2(7), CDH3(2), CDH4(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CNTN1(11), CNTN2(3), CNTNAP1(3), CNTNAP2(7), GLG1(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(1), ICAM3(2), ITGA4(5), ITGA6(7), ITGA8(10), ITGA9(2), ITGAL(6), ITGAM(3), ITGAV(5), ITGB1(1), ITGB7(1), JAM3(1), L1CAM(4), MADCAM1(2), MAG(3), MPZL1(3), NCAM1(4), NCAM2(12), NEGR1(5), NEO1(6), NFASC(6), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(8), NRXN2(7), NRXN3(8), OCLN(2), PDCD1(1), PDCD1LG2(2), PTPRC(9), PTPRF(3), PTPRM(9), PVR(2), PVRL1(5), PVRL3(6), SDC2(1), SDC3(1), SDC4(1), SELE(3), SELL(1), SELP(3), SELPLG(1), SIGLEC1(9), SPN(1), VCAM1(4), VCAN(14) 39978227 309 132 307 95 74 107 42 33 51 2 0.0950 1.000 1.000 444 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CHML(5), CHRM1(2), CHRM3(5), CHRM4(2), CHRM5(1), CMKLR1(5), CNR1(3), CNR2(1), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GPR17(1), GPR173(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(2), GPR4(1), GPR50(1), GPR63(3), GPR83(5), GPR85(2), GPR87(2), GRPR(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LHCGR(6), MAS1(1), MC1R(2), MC3R(1), MC4R(5), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPN3(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(2), OR7C1(1), OXTR(1), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY6(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), RGR(1), RHO(1), RRH(2), SSTR1(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2) 31788806 264 130 263 84 71 91 32 33 37 0 0.0331 1.000 1.000 445 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRB1(1), CSNK1D(1), DRD1(3), DRD2(4), EGF(4), EGFR(5), GJA1(1), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(16), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), HTR2A(4), HTR2C(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K5(2), MAP3K2(3), MAPK1(1), MAPK7(1), NPR1(6), NPR2(4), NRAS(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PRKACA(3), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), SOS1(3), SOS2(1), TJP1(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1) 36723608 248 130 245 70 73 81 39 27 28 0 0.0442 1.000 1.000 446 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(8), ACACB(9), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CALM3(1), CBL(6), CBLB(4), CBLC(3), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(1), FASN(7), FBP2(2), FLOT2(5), FOXO1(2), GCK(1), GSK3B(3), GYS1(2), GYS2(2), HRAS(1), IKBKB(2), INPP5D(4), INSR(9), IRS1(6), IRS2(3), IRS4(3), KRAS(3), LIPE(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(2), PDE3A(7), PDE3B(3), PFKL(1), PFKM(4), PFKP(2), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PKLR(3), PPARGC1A(5), PPP1CA(1), PPP1CB(1), PPP1R3A(8), PPP1R3D(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1B(2), PRKAR2B(3), PRKCI(1), PRKCZ(2), PTPN1(5), PTPRF(3), PYGB(3), PYGL(3), PYGM(4), RAF1(2), RAPGEF1(4), RHEB(1), SHC4(3), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(3), SOS2(1), SREBF1(3), TRIP10(7), TSC1(10), TSC2(7) 43840613 293 130 292 80 76 90 39 28 60 0 0.0195 1.000 1.000 447 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), ACVR1B(2), ACVR1C(2), BAIAP2(2), CDH1(1), CREBBP(13), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), EGFR(5), EP300(12), ERBB2(12), FARP2(3), FER(2), FGFR1(1), FYN(1), IGF1R(4), INSR(9), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MET(4), MLLT4(3), NLK(4), PARD3(7), PTPN1(5), PTPRB(2), PTPRF(3), PTPRJ(6), PTPRM(9), PVRL1(5), PVRL3(6), PVRL4(2), RAC1(1), RHOA(3), SMAD2(2), SMAD3(3), SNAI1(1), SNAI2(5), SORBS1(7), SSX2IP(2), TCF7L1(2), TGFBR1(2), TJP1(6), VCL(8), WASF1(3), WASF2(3), WASF3(3), WASL(2), YES1(5) 32595556 258 128 252 59 65 85 26 25 57 0 0.00449 1.000 1.000 448 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(1), ACTN2(8), ACTN4(4), ARHGAP5(8), BCAR1(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), CXCR4(1), CYBA(1), CYBB(2), EZR(1), GNAI1(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), ITK(7), JAM3(1), MAPK11(1), MAPK14(1), MLLT4(3), MMP2(3), MMP9(3), MSN(7), MYL7(2), MYL9(1), NCF1(1), NCF4(2), NOX1(1), NOX3(5), OCLN(2), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAC1(1), RAP1A(1), RAPGEF3(1), RAPGEF4(7), RASSF5(2), RHOA(3), ROCK1(2), ROCK2(4), SIPA1(3), TXK(1), VAV1(8), VAV2(1), VAV3(2), VCAM1(4), VCL(8) 33840257 241 125 237 68 55 84 36 23 43 0 0.0636 1.000 1.000 449 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(4), CACNA1A(13), CRHR1(2), GNA12(1), GNA13(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GNAZ(2), GRIA1(9), GRIA2(8), GRIA3(5), GRID2(7), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), IGF1(1), IGF1R(4), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NOS1(6), NOS3(5), NPR1(6), NPR2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), RYR1(13) 30965346 222 125 219 54 56 75 34 21 36 0 0.00767 1.000 1.000 450 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(4), AKT3(2), BCAR1(6), CAPN1(1), CAPN11(4), CAPN2(1), CAPN3(3), CAPN5(2), CAPN6(6), CAPN7(1), CAPN9(2), CAPNS1(3), CAV1(1), CRK(1), CSK(2), DOCK1(9), FYN(1), GIT2(2), ILK(2), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), MAP2K1(2), MAP2K2(3), MAPK10(3), MAPK4(2), MAPK6(3), MAPK7(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PIK3R2(3), PTK2(1), PXN(3), RAC1(1), RAPGEF1(4), RHO(1), ROCK1(2), ROCK2(4), SDCCAG8(2), SORBS1(7), SOS1(3), TLN1(7), TNS1(7), VAV2(1), VAV3(2), VCL(8), ZYX(1) 37560037 225 123 222 64 56 74 27 23 45 0 0.0862 1.000 1.000 451 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CBL(6), CBLB(4), CBLC(3), CCND1(1), CLCF1(1), CNTF(1), CREBBP(13), CRLF2(1), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), EP300(12), EPOR(2), GH1(1), GH2(2), GHR(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), LIFR(3), MPL(2), OSMR(3), PIAS3(1), PIAS4(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRL(2), PRLR(3), PTPN11(2), SOCS3(1), SOCS4(2), SOCS5(4), SOS1(3), SOS2(1), SPRED1(2), SPRED2(1), SPRY4(2), STAM(2), STAM2(3), STAT1(3), STAT2(4), STAT3(2), STAT4(5), STAT5A(3), STAT5B(2), STAT6(3), TPO(8), TSLP(1), TYK2(3) 39217560 244 122 243 74 49 74 27 38 56 0 0.353 1.000 1.000 452 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ATF4(2), CACNA1C(14), CACNA1D(7), CACNA1F(7), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), EGFR(5), ELK1(2), GNAQ(1), GNAS(16), GNRH1(1), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK9(2), MMP14(4), MMP2(3), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLD1(4), PLD2(3), PRKACA(3), PRKCA(1), PRKCD(2), PTK2B(4), RAF1(2), SOS1(3), SOS2(1) 35964483 218 118 214 63 61 72 23 25 37 0 0.117 1.000 1.000 453 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG6(2), ALG9(1), B3GNT1(4), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), B4GALT7(3), C1GALT1(1), CHPF(4), CHST1(1), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST6(2), CHST7(1), CHSY1(3), DDOST(1), EXT1(4), EXT2(1), EXTL3(3), FUT11(1), FUT8(2), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GANAB(2), GCNT1(3), GCNT3(1), GCNT4(4), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), NDST1(5), NDST2(5), NDST3(5), NDST4(6), OGT(3), RPN1(3), RPN2(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(2), STT3B(5), WBSCR17(10), XYLT1(3), XYLT2(3) 30302191 204 116 204 66 53 64 33 25 29 0 0.328 1.000 1.000 454 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADSL(3), AK5(3), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), ATP1B1(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), FHIT(3), GART(2), GDA(2), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NPR1(6), NPR2(4), NT5M(1), PAPSS2(3), PDE1A(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6B(1), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(4), PKLR(3), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), PRPS1(1), PRPS2(2) 35433583 198 116 197 75 42 61 30 27 38 0 0.864 1.000 1.000 455 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(2), ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), ATM(22), ATR(5), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDC14A(2), CDC14B(1), CDC20(3), CDC23(1), CDC25A(3), CDC25B(2), CDC26(1), CDC27(7), CDC6(5), CDC7(1), CDK2(1), CDK6(2), CDKN1A(2), CDKN1C(1), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(4), DBF4(3), E2F1(2), E2F2(2), E2F3(1), EP300(12), ESPL1(8), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), PKMYT1(2), PLK1(2), PRKDC(14), RB1(8), RBL1(2), RBL2(4), SMAD2(2), SMAD3(3), SMC1B(4), TFDP1(1), TGFB2(1), TGFB3(2), WEE1(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 37007120 216 114 216 39 27 75 25 27 61 1 0.00285 1.000 1.000 456 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(2), ACTN1(1), ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(4), CAV1(1), CRK(1), CSE1L(4), DOCK1(9), EPHB2(4), FYN(1), GRB7(3), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), MAP2K4(3), MAP3K11(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MRAS(1), MYLK(6), MYLK2(1), P4HB(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CB(4), PKLR(3), PLCG1(5), PLCG2(3), PTK2(1), RAF1(2), RALA(1), RHO(1), ROCK1(2), ROCK2(4), SOS1(3), SOS2(1), TERF2IP(1), TLN1(7), TLN2(11), ZYX(1) 32892198 197 114 196 53 42 72 21 26 36 0 0.0948 1.000 1.000 457 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), AKAP1(3), AKAP10(2), AKAP11(4), AKAP12(4), AKAP2(7), AKAP3(5), AKAP4(3), AKAP5(1), AKAP6(9), AKAP8(1), AKAP9(14), ARHGEF1(3), CALM3(1), CHMP1B(1), GNA12(1), GNA13(3), GNA14(1), GNA15(2), GNAI2(1), GNAI3(1), GNAL(2), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNGT1(1), HRAS(1), IL18BP(1), ITPR1(6), KRAS(3), NRAS(1), PALM2(3), PDE1A(3), PDE1B(3), PDE1C(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(1), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKD3(1), RHOA(3), SLC9A1(2), USP5(5) 31980176 217 112 213 55 57 64 32 27 37 0 0.0289 1.000 1.000 458 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), CALM3(1), CAMK2A(3), CAMK2B(2), CREB3L1(2), CREB3L2(1), CREB3L4(1), CREBBP(13), CTNNB1(9), DCT(4), DVL2(1), DVL3(2), EDNRB(3), EP300(12), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GSK3B(3), HRAS(1), KIT(7), KITLG(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MC1R(2), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), POMC(2), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), TCF7L1(2), TYR(3), TYRP1(1), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2) 29873284 209 112 207 61 70 60 33 16 30 0 0.0547 1.000 1.000 459 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(2), AMY2B(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENPP1(5), ENPP3(4), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), GAA(3), GANC(1), GBA(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), IFIH1(3), MGAM(9), MOV10L1(4), NUDT8(1), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SI(14), SKIV2L2(5), SMARCA2(8), SMARCA5(2), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UXS1(1) 34453355 180 110 179 55 25 66 27 27 35 0 0.492 1.000 1.000 460 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(8), ABCA12(14), ABCA13(19), ABCA2(7), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(9), ABCA7(5), ABCA8(3), ABCA9(3), ABCB1(7), ABCB10(2), ABCB11(6), ABCB4(4), ABCB5(3), ABCB6(6), ABCB7(1), ABCB8(1), ABCB9(1), ABCC1(3), ABCC10(1), ABCC11(8), ABCC12(5), ABCC2(6), ABCC3(2), ABCC4(6), ABCC5(7), ABCC8(6), ABCC9(12), ABCD2(3), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(6), ABCG4(1), ABCG5(1), ABCG8(3), CFTR(8), TAP2(1) 33068014 200 109 197 49 35 72 30 16 47 0 0.0125 1.000 1.000 461 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(11), ARAF(3), ATF4(2), BRAF(4), CACNA1C(14), CALM3(1), CAMK2A(3), CAMK2B(2), CREBBP(13), EP300(12), GNAQ(1), GRIA1(9), GRIA2(8), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R1A(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4) 28095699 181 108 180 55 41 60 25 27 28 0 0.248 1.000 1.000 462 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(3), BID(1), BRAF(4), CD244(3), CD48(1), FASLG(1), FCGR3A(1), FYN(1), HLA-A(1), HLA-B(7), HLA-C(4), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(1), ICAM2(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), ITGAL(6), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRD1(2), KLRK1(3), KRAS(3), LCK(1), LCP2(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MICA(2), MICB(1), NCR1(2), NCR2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NRAS(1), PAK1(2), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(4), PTPN11(2), RAC1(1), RAF1(2), SH2D1B(2), SHC4(3), SOS1(3), SOS2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), ULBP1(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3) 30762556 187 107 186 47 43 69 22 16 37 0 0.0223 1.000 1.000 463 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 87 ACVR1(1), ACVR1B(2), ACVR1C(2), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(2), BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CHRD(5), COMP(2), CREBBP(13), CUL1(4), DCN(6), E2F5(1), EP300(12), FST(1), GDF5(2), GDF6(1), GDF7(1), ID1(1), ID3(1), ID4(1), IFNG(1), INHBA(6), INHBB(1), INHBC(1), INHBE(4), LEFTY2(1), LTBP1(10), MAPK1(1), NODAL(1), NOG(1), PITX2(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), RBL1(2), RBL2(4), RHOA(3), ROCK1(2), ROCK2(4), SMAD2(2), SMAD3(3), SMAD6(1), SMAD9(2), SMURF1(2), SMURF2(2), SP1(1), TFDP1(1), TGFB2(1), TGFB3(2), TGFBR1(2), THBS1(2), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(3), ZFYVE9(4) 26462854 170 105 169 44 34 61 28 17 30 0 0.0974 1.000 1.000 464 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM3(1), CDS1(1), CDS2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5D(4), INPP5E(3), INPPL1(2), ITPK1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), PI4KA(7), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3C3(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PRKCA(1), PRKCG(2), PTPMT1(1), SYNJ1(7), SYNJ2(4) 34140113 188 104 188 53 43 69 14 22 39 1 0.0790 1.000 1.000 465 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(1), CD14(1), CD1A(5), CD1B(3), CD1C(4), CD1D(2), CD1E(6), CD2(1), CD22(5), CD33(2), CD34(2), CD36(2), CD38(2), CD3E(1), CD5(2), CD55(1), CD59(1), CD7(1), CD9(1), CR1(2), CR2(4), CSF1(1), CSF1R(9), CSF2RA(2), CSF3(2), CSF3R(5), DNTT(1), EPOR(2), FCER2(1), FLT3(9), FLT3LG(1), GP5(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(3), IL1R1(1), IL1R2(2), IL2RA(1), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL7R(3), IL9R(3), ITGA1(3), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGAM(3), ITGB3(2), KIT(7), KITLG(2), MME(4), TFRC(2), THPO(2), TPO(8) 22750395 169 102 167 46 29 57 22 23 37 1 0.155 1.000 1.000 466 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(4), AKT2(1), AKT3(2), BCL10(1), CARD11(5), CBL(6), CBLB(4), CBLC(3), CD28(1), CD3E(1), CD40LG(1), CHUK(5), FOS(1), FYN(1), GRAP2(4), HRAS(1), IFNG(1), IKBKB(2), IL10(2), ITK(7), JUN(1), KRAS(3), LCK(1), LCP2(4), MALT1(1), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDCD1(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCQ(4), PTPRC(9), RASGRP1(4), RHOA(3), SOS1(3), SOS2(1), TEC(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3) 27421585 182 102 180 42 38 62 29 19 34 0 0.0158 1.000 1.000 467 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(2), ABL2(1), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CAMK2A(3), CAMK2B(2), CBL(6), CBLB(4), CBLC(3), CDKN1A(2), CRK(1), EGF(4), EGFR(5), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(6), GAB1(1), GSK3B(3), HRAS(1), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), NCK1(1), NCK2(2), NRAS(1), NRG1(8), NRG2(2), NRG3(8), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), RAF1(2), SHC4(3), SOS1(3), SOS2(1), STAT5A(3), STAT5B(2), TGFA(1) 27187579 181 101 176 40 46 65 24 19 27 0 0.00381 1.000 1.000 468 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(2), ATM(22), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCNE1(2), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(3), CDC25A(3), CDC25B(2), CDC6(5), CDC7(1), CDH1(1), CDK2(1), CDKN1A(2), CHEK1(1), CHEK2(3), DTX4(2), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), EP300(12), ESPL1(8), GSK3B(3), HDAC1(1), HDAC3(3), HDAC5(2), HDAC6(3), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MPEG1(2), MPL(2), PLK1(2), PRKDC(14), PTPRA(4), RB1(8), RBL1(2), TBC1D8(3), TFDP1(1), WEE1(1) 29324590 161 99 161 30 25 55 20 17 44 0 0.00474 1.000 1.000 469 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(3), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(2), C3(9), C3AR1(3), C4BPA(1), C4BPB(1), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C8B(3), C9(2), CD46(5), CD55(1), CD59(1), CFH(10), CFI(1), CPB2(1), CR1(2), CR2(4), F10(2), F11(4), F12(2), F13A1(1), F13B(3), F2(4), F2R(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), KNG1(2), MASP1(4), MBL2(4), PLAT(1), PLG(3), PROC(1), PROS1(5), SERPINA1(2), SERPINA5(1), SERPINF2(2), TFPI(2), THBD(3), VWF(9) 24606103 155 97 153 33 34 52 15 21 33 0 0.0172 1.000 1.000 470 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(5), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(5), EED(2), EHMT1(6), EHMT2(4), EZH1(2), EZH2(1), FBXO11(3), HCFC1(4), HSF4(2), JMJD6(2), KDM6A(8), NSD1(14), OGT(3), PAXIP1(10), PPP1CA(1), PPP1CB(1), PRDM2(2), PRDM6(5), PRDM7(2), PRDM9(10), PRMT1(2), PRMT5(2), PRMT7(2), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(5), SETD1B(3), SETD2(7), SETD8(2), SETDB1(3), SETDB2(5), SETMAR(1), STK38(2), SUV420H1(5), SUV420H2(3), SUZ12(1), WHSC1(5), WHSC1L1(5) 34447065 154 96 150 31 34 49 13 21 36 1 0.0210 1.000 1.000 471 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), ACVR1B(2), ACVRL1(3), AKT1(4), AURKB(1), BMPR1A(1), BMPR2(3), BUB1(2), CDKL2(2), CDS1(1), CDS2(1), CLK1(2), CLK4(3), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MAP3K10(4), NEK1(3), NEK3(3), PAK4(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CB(4), PIK3CG(1), PIM2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3), PLK3(1), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKG1(3), RAF1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(5), TGFBR1(2), VRK1(1) 31311078 168 95 166 45 43 63 17 13 32 0 0.0647 1.000 1.000 472 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(4), CEBPA(2), CHUK(5), DAXX(3), ELK1(2), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP3K9(2), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAP4K5(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK4(2), MAPK6(3), MAPK7(1), MAPK8(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), MKNK2(2), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(2), RIPK1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), SP1(1), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1) 27086930 149 94 148 41 37 45 17 21 29 0 0.221 1.000 1.000 473 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), APH1A(1), CREBBP(13), CTBP2(2), DLL1(1), DTX1(3), DTX2(3), DTX3L(2), DTX4(2), DVL2(1), DVL3(2), EP300(12), HDAC1(1), HES1(1), JAG1(2), JAG2(4), LFNG(2), MAML1(2), MAML2(6), MAML3(4), NCOR2(12), NCSTN(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(1), RBPJ(1), RBPJL(6), SNW1(1) 19872809 145 90 144 51 36 39 11 14 43 2 0.768 1.000 1.000 474 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(1), ALG6(2), CCKBR(3), CCR2(1), CCR3(2), CCR5(1), CELSR1(8), CELSR2(10), CELSR3(7), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(2), EMR3(3), F2R(4), FSHR(6), GHRHR(2), GPR116(5), GPR132(1), GPR133(3), GPR17(1), GPR18(1), GPR55(1), GPR56(3), GPR84(3), GPR88(1), GRM1(9), GRPR(1), HRH4(2), LGR6(5), LPHN2(9), LPHN3(9), NTSR1(1), OR2M4(4), P2RY11(2), P2RY13(3), PTGFR(1), SMO(4), TAAR5(2), TSHR(3), VN1R1(3) 17755835 137 88 136 39 33 50 20 13 21 0 0.0913 1.000 1.000 475 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), CABIN1(8), CALM3(1), CAMK2B(2), CD3E(1), CDKN1A(2), CNR1(3), CREBBP(13), CSNK2A1(1), EP300(12), FCGR3A(1), FOS(1), FOSL1(2), GATA3(4), GSK3A(2), GSK3B(3), HRAS(1), IFNB1(1), IFNG(1), IL10(2), IL1B(3), IL2RA(1), IL3(2), IL6(1), ITK(7), KPNA5(1), MAPK14(1), MAPK8(1), MAPK9(2), MEF2A(1), MEF2D(3), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB2(2), NUP214(2), OPRD1(1), P2RX7(2), PAK1(2), PPP3CB(2), PPP3CC(3), PTPRC(9), RPL13A(1), SLA(3), SP1(1), SP3(2), TRAF2(1), TRPV6(3), VAV1(8), VAV2(1), VAV3(2), XPO5(2) 25157462 155 86 154 34 34 55 21 10 35 0 0.0121 1.000 1.000 476 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(4), AKT2(1), AKT3(2), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CAPN1(1), CAPN2(1), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CSF2RB(6), DFFA(1), DFFB(2), ENDOG(1), FADD(1), FASLG(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL3(2), IL3RA(1), IRAK1(2), IRAK3(1), IRAK4(1), NFKB1(2), NFKB2(2), NTRK1(5), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), TRAF2(1) 22416262 137 85 137 36 32 43 15 16 31 0 0.0984 1.000 1.000 477 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CD22(5), CD81(1), CR2(4), CSK(2), DAG1(1), FLOT2(5), GSK3A(2), GSK3B(3), INPP5D(4), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), MAPK1(1), NFATC1(4), NFATC2(6), NR0B2(1), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTPRC(9), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8) 19664108 120 84 119 34 31 40 10 13 25 1 0.163 1.000 1.000 478 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(4), CPEB1(1), EGFR(5), ERBB2(12), ETS1(1), ETV7(1), FMN2(20), KRAS(3), MAP2K1(2), MAPK1(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), PIWIL1(4), PIWIL2(3), PIWIL3(1), RAF1(2), SOS1(3), SOS2(1), SPIRE1(2), SPIRE2(3) 14020846 115 83 110 34 23 45 12 11 22 2 0.388 1.000 1.000 479 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(4), CLK3(1), CLK4(3), COL2A1(8), CPSF1(5), CPSF2(3), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(4), DDX20(1), DHX15(2), DHX16(1), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(3), GIPC1(5), LSM7(1), METTL3(2), NCBP1(1), NONO(1), PABPN1(1), PAPOLA(2), POLR2A(3), PRPF18(1), PRPF3(2), PRPF4(3), PRPF4B(2), PRPF8(5), PSKH1(1), PTBP1(3), RBM5(2), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(4), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(4), SF3B4(1), SNRPD2(1), SNRPF(1), SNRPN(4), SNURF(1), SPOP(2), SRPK1(3), SRPK2(2), SUPT5H(3), TXNL4A(1), U2AF2(1), XRN2(1) 29207358 136 83 136 35 30 49 14 13 30 0 0.264 1.000 1.000 480 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(6), CD28(1), CSK(2), DAG1(1), DTYMK(2), EPHB2(4), GRAP2(4), ITK(7), ITPKB(6), LCK(1), LCP2(4), MAPK1(1), NCK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLCG1(5), PTPRC(9), RAF1(2), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), SOS1(3), SOS2(1), VAV1(8), ZAP70(3) 15279966 105 82 104 30 24 38 13 12 18 0 0.216 1.000 1.000 481 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(4), AKT2(1), AKT3(2), BTK(1), FYN(1), GAB2(2), HRAS(1), IL3(2), INPP5D(4), KRAS(3), LCP2(4), LYN(2), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MS4A2(1), NRAS(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCD(2), PRKCE(2), RAC1(1), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8), VAV2(1), VAV3(2) 19374931 112 81 110 26 32 42 13 7 18 0 0.0308 1.000 1.000 482 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), ENTPD4(1), ENTPD5(3), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(2), NT5M(1), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), RFC5(1), RRM2B(1), TXNRD1(3), TXNRD2(2), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2), UPP2(1) 22592480 127 80 127 39 32 44 16 11 24 0 0.319 1.000 1.000 483 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(4), AKT2(1), AKT3(2), BCL10(1), BLNK(3), BTK(1), CARD11(5), CD22(5), CD79A(2), CD81(1), CHUK(5), CR2(4), FCGR2B(1), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(4), JUN(1), KRAS(3), LILRB3(1), LYN(2), MALT1(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RASGRP3(2), SYK(2), VAV1(8), VAV2(1), VAV3(2) 19940536 128 80 126 34 27 44 18 8 30 1 0.113 1.000 1.000 484 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(9), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADIPOR1(2), AKT1(4), AKT2(1), AKT3(2), CAMKK2(4), CD36(2), CHUK(5), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), IKBKB(2), IRS1(6), IRS2(3), IRS4(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PCK1(2), PCK2(2), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(4), PTPN11(2), SLC2A1(1), SOCS3(1), STAT3(2), STK11(5), TNFRSF1B(1), TRAF2(1), TYK2(3) 22938755 130 79 129 42 34 41 18 9 28 0 0.363 1.000 1.000 485 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(4), CALM3(1), CAV1(1), CHRM1(2), CHRNA1(4), FLT1(7), FLT4(5), KDR(5), NOS3(5), PDE2A(3), PDE3A(7), PDE3B(3), PRKAR1B(2), PRKAR2B(3), PRKG1(3), PRKG2(5), RYR2(35), SLC7A1(2), SYT1(3) 11455365 101 77 99 31 22 36 18 7 18 0 0.240 1.000 1.000 486 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(2), AMY2B(5), ENPP1(5), ENPP3(4), GAA(3), GANAB(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), MGAM(9), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RNPC3(4), SI(14), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UXS1(1) 15984577 96 76 95 30 14 39 21 10 12 0 0.479 1.000 1.000 487 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(4), AKT2(1), AKT3(2), CASP8(6), CCL5(1), CD14(1), CD80(1), CD86(1), CHUK(5), FADD(1), FOS(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IKBKB(2), IKBKE(2), IL12B(1), IL1B(3), IL6(1), IRAK1(2), IRAK4(1), IRF5(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K7(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), RAC1(1), RIPK1(2), STAT1(3), TICAM1(1), TLR1(2), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TLR8(2), TOLLIP(1), TRAF3(1), TRAF6(1) 23696769 119 75 118 33 22 39 21 10 27 0 0.195 1.000 1.000 488 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(1), ADCY8(11), CACNA1A(13), CACNA1B(6), GNAS(16), GRM4(7), ITPR3(2), KCNB1(1), PDE1A(3), PLCB2(1), PRKACA(3), SCNN1A(3), SCNN1B(1), SCNN1G(5), TAS1R1(2), TAS1R2(4), TAS1R3(2), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R39(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R46(3), TAS2R50(2), TAS2R60(3), TAS2R7(1), TAS2R8(1), TRPM5(1) 16025855 105 75 103 38 37 26 13 12 17 0 0.519 1.000 1.000 489 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), GSN(3), LMNA(2), LMNB1(1), LMNB2(5), MAP3K1(8), MAP3K5(8), MAPK8(1), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(14), PSEN1(2), PSEN2(1), PTK2(1), RASA1(9), RB1(8), RIPK1(2), SPTAN1(8), TNFRSF1B(1), TRAF1(2), TRAF2(1) 19209511 123 74 122 33 24 33 15 15 36 0 0.421 1.000 1.000 490 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5E(3), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKB(6), MIOX(2), PI4KA(7), PI4KB(1), PIK3C3(1), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PTPMT1(1), SYNJ1(7), SYNJ2(4) 19797452 111 74 111 34 24 49 6 10 21 1 0.203 1.000 1.000 491 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(15), AXIN1(2), CCND1(1), CSNK1E(1), CTNNB1(9), DVL2(1), DVL3(2), FBXW2(2), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LDLR(3), MAPK10(3), MAPK9(2), PAFAH1B1(1), PPP2R5C(4), PPP2R5E(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), RAC1(1), RHOA(3), SFRP4(3), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT5B(2), WNT7B(3) 16238863 117 73 115 32 31 30 23 7 25 1 0.195 1.000 1.000 492 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(2), ATP8A1(9), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CX3CR1(3), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(3), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GRPR(1), LHCGR(6), MC1R(2), MC2R(1), MC3R(1), MC4R(5), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), SSTR1(2), SSTR3(2), SSTR4(2), TAC4(1), TACR3(3), TSHR(3) 13766976 102 72 101 43 25 35 20 5 17 0 0.736 1.000 1.000 493 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(4), APOA1(1), CD36(2), CITED2(2), CPT1B(6), CREBBP(13), EHHADH(1), EP300(12), HSD17B4(4), JUN(1), LPL(2), MAPK1(1), ME1(1), MRPL11(1), NCOA1(7), NCOR1(4), NCOR2(12), NR0B2(1), NRIP1(3), PDGFA(2), PIK3R1(5), PPARA(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RB1(8), SP1(1), STAT5A(3), STAT5B(2) 16773784 106 72 105 31 20 38 7 4 37 0 0.459 1.000 1.000 494 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(17), B3GALT4(1), CDR1(3), DGKI(11), IL6ST(5), MRPL19(3), PIGK(2), RPL10(1), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL23(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36(1), RPL38(1), RPL3L(1), RPL6(1), RPL7A(2), RPL8(2), RPLP0(1), RPLP1(1), RPS10(1), RPS11(2), RPS13(2), RPS14(2), RPS19(3), RPS24(1), RPS26(2), RPS5(2), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), RPS9(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1) 14646713 94 70 94 29 22 31 7 14 20 0 0.572 1.000 1.000 495 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BAK1(1), BAX(2), BTK(1), CAD(11), CASP8(6), CD7(1), CSNK1A1(2), DAXX(3), DEDD(1), DEDD2(1), DFFA(1), EGFR(5), EPHB2(4), FADD(1), FAF1(3), FAIM2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MET(4), NFAT5(4), NFKB1(2), NFKB2(2), NR0B2(1), PTPN13(7), RALBP1(2), RIPK1(2), ROCK1(2), SMPD1(2), TPX2(3), TRAF2(1) 19959067 107 69 107 35 25 35 12 13 22 0 0.589 1.000 1.000 496 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(1), ALPP(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), FPGS(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SKIV2L2(5), SMARCA2(8), SMARCA5(2), SPR(1) 17413325 92 68 92 34 13 31 9 17 22 0 0.827 1.000 1.000 497 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(4), AKT2(1), AKT3(2), BRD4(8), CBL(6), F2RL2(1), FLOT2(5), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), LNPEP(3), MAPK1(1), PARD3(7), PARD6A(1), PIK3CD(5), PIK3R1(5), PTPN1(5), RAF1(2), RPS6KA1(1), RPS6KA2(1), SERPINB6(1), SORBS1(7), SOS1(3), SOS2(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1) 15116339 95 68 95 28 25 25 9 10 26 0 0.399 1.000 1.000 498 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), CARM1(2), DBH(1), DCT(4), DDC(2), ESCO1(3), ESCO2(1), FAH(2), HEMK1(1), HGD(2), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), MIF(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(2), TH(3), TPO(8), TYR(3), TYRP1(1) 16272572 79 66 79 29 25 26 3 7 18 0 0.592 1.000 1.000 499 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(1), BIRC3(2), BNIP3L(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CHUK(5), DFFA(1), DFFB(2), FADD(1), FASLG(1), HELLS(2), IKBKB(2), IRF1(1), IRF4(4), IRF5(1), IRF6(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MDM2(2), NFKB1(2), PLEKHG5(4), PRF1(4), RIPK1(2), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFSF10(1), TP73(3), TRAF1(2), TRAF2(1), TRAF3(1) 15573430 97 65 97 25 24 28 13 12 20 0 0.185 1.000 1.000 500 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADH(1), HADHA(2), HSD17B4(4), HSD3B7(2), NSD1(14), OGDH(2), OGDHL(6), PIPOX(1), PLOD1(3), PLOD2(3), PLOD3(4), RDH13(1), SETD1A(5), SETDB1(3), SHMT1(2), SHMT2(2), TMLHE(1) 15831521 95 65 95 28 24 37 7 7 19 1 0.288 1.000 1.000 501 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT4(3), AGPAT6(1), CDS1(1), CDS2(1), CHAT(8), CHKB(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), ESCO1(3), ESCO2(1), ETNK1(2), ETNK2(2), GNPAT(1), GPAM(1), GPD2(2), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3), PTDSS1(2), SH3GLB1(2) 18177635 93 65 92 23 30 30 7 7 19 0 0.0792 1.000 1.000 502 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(5), ACOX1(4), ACOX2(2), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ANGPTL4(2), APOA1(1), APOA5(2), APOC3(3), AQP7(1), CD36(2), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A22(2), CYP8B1(1), EHHADH(1), FABP4(1), FABP6(1), FADS2(2), GK(1), GK2(4), HMGCS2(2), ILK(2), LPL(2), ME1(1), MMP1(1), PCK1(2), PCK2(2), PLTP(3), PPARA(1), PPARG(2), SCD(3), SCP2(1), SLC27A2(2), SLC27A4(1), SLC27A5(1), SLC27A6(6), SORBS1(7), UCP1(1) 17867386 97 65 95 27 26 37 6 5 23 0 0.160 1.000 1.000 503 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(1), AKT1(4), CALM3(1), CALR(2), CAMK1(1), CAMK1G(2), CREBBP(13), CSNK1A1(2), F2(4), GSK3B(3), HRAS(1), IGF1(1), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK8(1), MEF2C(2), MYH2(10), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKX2-5(3), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), RAF1(2), SYT1(3) 13143720 93 65 93 31 27 22 11 5 28 0 0.481 1.000 1.000 504 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF11(1), BTK(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(2), ITPR1(6), ITPR2(8), ITPR3(2), LIMK1(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CD(5), PIK3CG(1), PIK3R1(5), PITX2(1), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(2), ROCK2(4), SAG(1), WASF1(3), WASL(2) 18526234 89 65 89 27 20 24 13 17 15 0 0.411 1.000 1.000 505 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CSK(2), DAG1(1), EPHB2(4), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), RAF1(2), SERPINA4(4), SOS1(3), SOS2(1), SYK(2), VAV1(8) 14088478 81 64 81 26 22 29 4 8 18 0 0.372 1.000 1.000 506 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(4), BRAF(4), CREB5(2), CREBBP(13), DAG1(1), EGR1(2), EGR4(1), ELK1(2), FRS2(1), GNAQ(1), JUN(1), MAP1B(13), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), NTRK1(5), PIK3C2G(4), PIK3CD(5), PIK3R1(5), PTPN11(2), TERF2IP(1), TH(3) 13527526 85 62 85 29 21 24 7 10 23 0 0.580 1.000 1.000 507 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AGPAT6(1), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DAK(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), GK(1), GK2(4), GLB1(2), GPAM(1), LCT(8), LIPF(3), LIPG(1), LPL(2), MGLL(1), PNLIPRP1(2), PPAP2A(2), PPAP2B(3) 16301098 91 61 91 37 31 26 10 9 15 0 0.717 1.000 1.000 508 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(4), APC(15), AR(5), BRAF(4), CCL16(2), DAG1(1), EGFR(5), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(3), MAPK14(1), PHKA2(3), PIK3CD(5), PIK3R1(5), PITX2(1), PTX3(1), RAF1(2) 13929184 88 61 87 36 16 26 13 12 21 0 0.899 1.000 1.000 509 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(4), AKT2(1), AKT3(2), ARHGEF11(1), DLG4(4), GNA13(3), LPA(10), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK8(1), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RDX(6), ROCK1(2), ROCK2(4), SERPINA4(4), TBXA2R(2) 13762826 83 61 82 27 22 25 13 6 17 0 0.533 1.000 1.000 510 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), NT5M(1), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), TXNRD1(3), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2) 15903058 80 60 79 33 18 28 9 11 14 0 0.869 1.000 1.000 511 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(4), AKT2(1), AKT3(2), BRAF(4), DAG1(1), DRD2(4), EGFR(5), EPHB2(4), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PIK3CB(4), PITX2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), RAF1(2), RGS20(2), SOS1(3), SOS2(1), STAT3(2), TERF2IP(1) 16125997 80 60 80 29 15 33 4 14 14 0 0.624 1.000 1.000 512 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP6(1), CASP7(1), CASP8(6), CFLAR(2), DAXX(3), DFFA(1), DFFB(2), FADD(1), FAF1(3), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), PTPN13(7), RB1(8), RIPK2(1), SPTAN1(8) 11725820 85 59 84 25 11 17 7 18 32 0 0.795 1.000 1.000 513 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(4), AKT2(1), AKT3(2), BCR(4), BTK(1), DAPP1(1), FLOT2(5), GAB1(1), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), NR0B2(1), PITX2(1), PLCG2(3), PPP1R13B(4), PREX1(5), PTPRC(9), RPS6KA1(1), RPS6KA2(1), SAG(1), SYK(2), TEC(1), VAV1(8) 14511310 74 59 74 22 15 27 8 12 12 0 0.278 1.000 1.000 514 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(2), ACTR3(1), AKT1(4), ANGPTL2(3), CFL1(1), FLNA(3), FLNC(10), FSCN1(1), FSCN2(2), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(10), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), RHO(1), ROCK1(2), ROCK2(4), WASF1(3), WASL(2) 13261959 79 59 79 25 18 19 16 12 14 0 0.436 1.000 1.000 515 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3) 13443830 76 58 76 25 23 26 6 6 15 0 0.394 1.000 1.000 516 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3) 13443830 76 58 76 25 23 26 6 6 15 0 0.394 1.000 1.000 517 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(8), ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6A(3), LDHAL6B(1), PDHA2(5), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PGM1(1), PKLR(3) 16081950 85 58 85 32 24 34 4 9 14 0 0.605 1.000 1.000 518 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(9), AR(5), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(2), NR1D2(3), NR1I2(2), NR2C2(4), NR2F2(1), NR2F6(1), NR3C1(1), NR4A1(1), NR4A2(3), NR5A2(6), PGR(5), PPARA(1), PPARG(2), RARB(1), RARG(1), ROR1(2), RORA(2), THRA(6), THRB(1), VDR(2) 11421800 76 58 76 25 21 28 8 9 9 1 0.373 1.000 1.000 519 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(4), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), COX5A(1), COX6B2(1), COX6C(1), COX7A1(1), COX8C(1), LHPP(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA4(1), NDUFA7(1), NDUFB10(1), NDUFB7(1), NDUFB8(2), NDUFC2(1), NDUFS1(1), NDUFS2(2), NDUFS3(1), NDUFS8(1), NDUFV2(1), NDUFV3(2), PPA1(1), PPA2(1), SDHA(4), SDHD(2), TCIRG1(1), UQCRC2(4), UQCRFS1(1), UQCRQ(1) 15541817 73 57 73 21 19 25 6 10 13 0 0.259 1.000 1.000 520 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(8), BCAR1(6), BCR(4), CAPN1(1), CAPNS1(3), CAPNS2(1), CAV1(1), CSK(2), FYN(1), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), PPP1R12B(1), PTK2(1), PXN(3), RAF1(2), RAP1A(1), ROCK1(2), SOS1(3), TLN1(7), VCL(8), ZYX(1) 13230562 71 57 69 25 26 28 5 7 5 0 0.378 1.000 1.000 521 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), GK(1), GLB1(2), LCT(8), LIPF(3), LIPG(1), LPL(2), PNLIPRP1(2), PPAP2A(2), PPAP2B(3) 13430978 79 56 79 28 28 23 10 5 13 0 0.454 1.000 1.000 522 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(6), CARS(5), CARS2(2), DARS2(2), EARS2(1), EPRS(3), FARSA(2), FARSB(1), GARS(3), HARS(1), HARS2(1), IARS(4), IARS2(1), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), MTFMT(1), NARS2(1), QARS(3), RARS(4), RARS2(1), SARS(2), SARS2(1), TARS(6), TARS2(2), VARS(2), VARS2(2), WARS(1), WARS2(2), YARS(1), YARS2(2) 14795164 78 55 78 20 22 27 11 8 10 0 0.167 1.000 1.000 523 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(2), GNAS(16), GNGT1(1), HRAS(1), IGF1R(4), ITGB1(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(4), PPP2CA(1), PTPRR(6), RAF1(2), RPS6KA1(1), RPS6KA5(4), SOS1(3), STAT3(2) 9301134 65 54 65 24 21 20 9 7 8 0 0.672 1.000 1.000 524 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(4), APC(15), DAG1(1), DLG4(4), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(1), PTX3(1), RAC1(1), RHO(1), RYR1(13) 12596477 69 54 68 20 12 22 10 9 16 0 0.358 1.000 1.000 525 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), DBH(1), DCT(4), DDC(2), FAH(2), HGD(2), MAOA(2), MAOB(3), TAT(2), TH(3), TPO(8), TYR(3) 8813162 59 53 59 24 22 16 3 6 12 0 0.662 1.000 1.000 526 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(1), ARG2(1), ASL(3), ASS1(1), CKB(2), CKM(1), CPS1(11), DAO(1), EPRS(3), GAMT(1), GATM(2), GLUD1(1), GLUD2(4), LAP3(1), NOS1(6), NOS3(5), OAT(3), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), PYCR2(1), PYCRL(1), RARS(4), RARS2(1) 10098952 64 52 64 19 17 23 8 5 11 0 0.313 1.000 1.000 527 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(2), CHUK(5), DAXX(3), EGF(4), EGFR(5), ETS1(1), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK14(1), MAPK8(1), NFKB1(2), PPP2CA(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), RAF1(2), RIPK1(2), SP1(1), TNFRSF1B(1), TRAF2(1) 13434688 72 52 71 23 20 21 13 7 11 0 0.460 1.000 1.000 528 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(2), BCL2A1(1), BCL2L1(1), BCL2L2(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CD40LG(1), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), FASLG(1), IKBKE(2), MCL1(1), NFKB1(2), NGFR(2), NR3C1(1), NTRK1(5), PTPN13(7), RIPK1(2), TFG(2), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1), TRAF6(1) 12028345 64 50 64 19 18 17 9 8 12 0 0.347 1.000 1.000 529 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C2(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(3), CYP1A2(1), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2F1(4), CYP2S1(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), EPHX1(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), MGST3(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1) 15887502 69 50 69 19 16 26 6 10 11 0 0.249 1.000 1.000 530 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(2), CALM3(1), CAMK2A(3), CAMK2B(2), F2(4), FYN(1), GNAI1(1), GNGT1(1), HRAS(1), JAK2(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK14(1), MAPK8(1), MAPT(1), MYLK(6), PLCG1(5), PRKCA(1), PTK2B(4), RAF1(2), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), SYT1(3) 11643217 60 49 60 20 17 21 9 3 10 0 0.476 1.000 1.000 531 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM3(1), CAMK1(1), CAMK1G(2), ELK1(2), FPR1(1), GNA15(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NCF1(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PAK1(2), PIK3C2G(4), PLCB1(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RAF1(2), SYT1(3) 10677336 66 49 66 21 18 19 7 8 14 0 0.420 1.000 1.000 532 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR3(1), AKT1(4), ANGPTL2(3), DAG1(1), DGKA(3), ETFA(1), ITGA9(2), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), MAP2K1(2), MAPK1(1), PAK1(2), PDE3A(7), PDE3B(3), PIK3C2G(4), PIK3CD(5), PIK3R1(5), PSME1(1), SGCB(1) 12830779 68 49 68 26 12 19 9 11 17 0 0.776 1.000 1.000 533 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), CALM3(1), EGFR(5), ELK1(2), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), MEF2A(1), MEF2C(2), MEF2D(3), PAK1(2), PRKCA(1), PTK2(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3) 9489899 53 47 53 19 13 18 5 6 11 0 0.649 1.000 1.000 534 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(1), B4GALT6(3), CERK(4), DEGS1(1), DEGS2(1), ENPP7(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SGMS1(1), SMPD1(2), SMPD3(1), SMPD4(1), SPHK2(3), SPTLC1(1), SPTLC2(4), UGCG(1), UGT8(1) 9843835 54 47 54 20 11 20 6 4 13 0 0.579 1.000 1.000 535 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AMDHD1(3), AOC2(4), AOC3(5), ASPA(2), CARM1(2), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(2), HEMK1(1), HNMT(1), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(3) 10969610 60 46 60 20 18 19 3 10 10 0 0.469 1.000 1.000 536 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(8), ARHGAP6(2), ARHGEF1(3), ARHGEF11(1), ARHGEF5(1), BAIAP2(2), CFL1(1), DIAPH1(2), GSN(3), LIMK1(1), MYLK(6), OPHN1(1), PIP5K1A(1), PPP1R12B(1), ROCK1(2), TLN1(7), VCL(8) 12589405 51 46 49 21 10 19 11 4 7 0 0.781 1.000 1.000 537 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(3), ELK1(2), HRAS(1), HSPB2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), PLA2G4A(1), RAC1(1), RIPK1(2), RPS6KA5(4), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1) 10317674 60 44 59 18 17 16 6 9 12 0 0.457 1.000 1.000 538 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(8), DIAPH1(2), FYN(1), GSN(3), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), MYLK(6), PIK3R1(5), PTK2(1), PXN(3), RAF1(2), ROCK1(2), TLN1(7) 9680367 48 43 48 20 10 18 11 3 6 0 0.805 1.000 1.000 539 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(2), POLB(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLH(2), POLI(1), POLM(1), POLQ(9), PRIM1(4), PRIM2(3), REV1(4), REV3L(11), RFC5(1) 11320976 57 43 57 23 8 23 8 10 8 0 0.900 1.000 1.000 540 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(3), AKT1(4), AKT2(1), AKT3(2), DAG1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PITX2(1), PLD1(4), PLD2(3), PLD3(1), VN1R1(3) 12621471 57 43 56 25 11 20 4 7 15 0 0.895 1.000 1.000 541 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(4), BLNK(3), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK1(1), MAPK8IP3(4), PAPPA(6), RAC1(1), RPS6KA1(1), SOS1(3), SYK(2), VAV1(8), VAV2(1), VAV3(2) 8939971 53 42 53 17 10 13 8 9 13 0 0.632 1.000 1.000 542 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), BTG1(1), CBX3(1), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(4), EIF4G2(1), GFRA1(3), GSTM3(1), GSTP1(1), HERPUD1(1), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(2), NR1D2(3), PER1(5), PER2(5), PURA(1), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), VAPA(1), ZFR(2) 10038928 54 41 54 19 9 19 7 4 15 0 0.759 1.000 1.000 543 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), DFFA(1), DFFB(2), FADD(1), GAS2(2), LMNA(2), NFKB1(2), RIPK1(2), SPTAN1(8), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(4), TNFSF10(1), TNFSF12(2), TRAF2(1) 9209228 53 41 53 18 11 16 6 9 11 0 0.719 1.000 1.000 544 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), ALDOC(4), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6B(1), MDH1(2), MDH2(2), PC(1), PCK1(2), PDHA2(5), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PKLR(3), TNFAIP1(1) 11691304 53 41 53 18 13 21 6 3 10 0 0.448 1.000 1.000 545 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(4), BCL2L1(1), CBL(6), CFLAR(2), E2F1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), IRS1(6), JAK1(3), JAK3(6), MAPK1(1), PIK3R1(5), RAF1(2), SOCS3(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 9504671 55 41 55 17 11 12 7 14 11 0 0.586 1.000 1.000 546 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM3(1), CHUK(5), GNAQ(1), MAP3K1(8), NFATC1(4), NFATC2(6), NFKB1(2), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), SYT1(3), VIP(2) 7453006 48 40 48 19 11 13 6 3 15 0 0.848 1.000 1.000 547 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), ARSD(1), CARM1(2), CYP11B1(2), CYP11B2(4), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD11B2(1), HSD17B1(1), HSD3B1(2), HSD3B2(3), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1) 13674297 48 39 48 21 9 23 4 4 8 0 0.873 1.000 1.000 548 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(5), ARHGEF1(3), F2(4), F2R(4), F2RL3(2), GNA12(1), GNA13(3), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(3), PIK3R1(5), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2B(4), ROCK1(2) 6512705 44 39 43 15 7 13 5 5 14 0 0.745 1.000 1.000 549 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(15), CERK(4), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKB(6), JUN(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2) 7555571 50 39 49 18 9 15 7 3 16 0 0.820 1.000 1.000 550 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(6), CRK(1), CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(1), NFKB1(2), PIK3C2G(4), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PTK2B(4), PXN(3), RAF1(2) 7192971 42 38 42 14 11 14 4 4 9 0 0.525 1.000 1.000 551 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), FUK(5), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), HSD3B7(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), PFKFB1(2), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1), RDH13(1), TSTA3(2) 10507009 54 38 53 20 12 24 3 5 10 0 0.512 1.000 1.000 552 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(5), HRAS(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(6), PRKAR1B(2), PRKAR2B(3), PTK2(1), PXN(3), TLN1(7) 9090625 45 38 45 24 12 20 6 2 5 0 0.921 1.000 1.000 553 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(1), GTF2F1(5), HDAC3(3), NCOA1(7), NCOA2(6), NCOA3(3), NCOR2(12), POLR2A(3), TBP(2) 6960463 43 38 43 16 7 19 3 4 10 0 0.696 1.000 1.000 554 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), CFL1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), LIMK1(1), MAP2K1(2), MAPK1(1), NOX1(1), PIK3C2G(4), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2(1), RAF1(2), ROCK2(4) 7040132 43 37 43 13 15 15 5 3 5 0 0.425 1.000 1.000 555 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(3), B4GALT2(1), FBP2(2), GAA(3), GALE(1), GANAB(2), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), LCT(8), MGAM(9), PFKM(4), PFKP(2), PGM1(1) 9016164 45 37 45 16 11 17 6 2 9 0 0.593 1.000 1.000 556 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(2), C6(6), C7(4), ICAM1(1), IL6(1), ITGA4(5), ITGAL(6), ITGB1(1), SELP(3), SELPLG(1), VCAM1(4) 6813809 43 37 43 16 4 20 3 7 9 0 0.710 1.000 1.000 557 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(2), DAG1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFAT5(4), PDE6A(2), PDE6B(1), PDE6C(3), PDE6H(2), SLC6A13(5), TF(4) 9860333 49 37 49 19 8 24 4 6 7 0 0.644 1.000 1.000 558 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(8), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(3), ITGB1(1), ITGB3(2), PTK2(1), PXN(3), RAC1(1), SPTAN1(8), TLN1(7) 7899281 41 37 41 17 14 17 0 5 5 0 0.657 1.000 1.000 559 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), ATP7B(4), COX5A(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRFS1(1) 10502103 42 36 42 12 12 12 5 6 7 0 0.314 1.000 1.000 560 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK5(2), NFKB1(2), NFKB2(2), PIK3CD(5), PIK3R1(5), SYT1(3), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1) 8934149 43 36 43 14 13 8 3 3 16 0 0.566 1.000 1.000 561 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSD(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SMPD1(2), SPTLC1(1), SPTLC2(4), UGCG(1) 6588452 39 35 39 16 9 14 6 2 8 0 0.715 1.000 1.000 562 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(3), B4GALT2(1), GAA(3), GALE(1), GANC(1), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), HSD3B7(2), LCT(8), MGAM(9), PFKL(1), PFKM(4), PFKP(2), PGM1(1), RDH13(1) 10750438 46 35 46 17 13 15 6 3 9 0 0.623 1.000 1.000 563 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(5), IFNB1(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK1(2), IRAK3(1), JUN(1), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), TGFB2(1), TGFB3(2), TOLLIP(1), TRAF6(1) 8225044 40 35 39 16 8 11 4 6 11 0 0.860 1.000 1.000 564 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(4), BCR(4), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3R1(5), RAF1(2), SOS1(3), STAT1(3), STAT5A(3), STAT5B(2) 7122921 45 34 45 16 11 12 4 6 12 0 0.720 1.000 1.000 565 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(5), CCNB1(1), GNAI1(1), GNAS(16), GNGT1(1), HRAS(1), MAPK1(1), MYT1(4), PRKAR1B(2), PRKAR2B(3), RPS6KA1(1) 5623036 37 33 37 18 13 10 4 3 7 0 0.900 1.000 1.000 566 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(5), AKT1(4), GNAI1(1), GNGT1(1), ITGAV(5), ITGB3(2), MAPK1(1), PDGFA(2), PDGFRA(4), PIK3R1(5), PLCB1(3), PRKCA(1), PTK2(1), RAC1(1), SMPD1(2) 6872356 38 32 38 15 10 8 5 3 12 0 0.781 1.000 1.000 567 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(1), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGW(1), PIGZ(1) 6769771 33 32 33 13 4 14 4 6 5 0 0.732 1.000 1.000 568 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(4), ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), HSD3B7(2), RDH13(1), SLC27A5(1), SOAT1(1), SOAT2(1) 8820515 40 31 40 20 12 12 5 4 7 0 0.912 1.000 1.000 569 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(4), F2RL3(2), GNAI1(1), GNGT1(1), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), PTK2(1), RAF1(2), SYK(2), TBXAS1(2) 6688883 34 31 34 14 11 13 3 2 5 0 0.709 1.000 1.000 570 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(2), E2F1(2), MDM2(2), PIK3R1(5), POLR1A(4), POLR1B(3), POLR1C(5), RAC1(1), RB1(8), TBX2(2), TWIST1(2) 4569861 36 30 36 13 4 8 2 3 19 0 0.881 1.000 1.000 571 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(2), CASP8(6), FADD(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFKB1(2), NSMAF(4), RAF1(2), RIPK1(2), SMPD1(2), TRAF2(1) 5541878 37 30 37 13 10 12 5 4 6 0 0.619 1.000 1.000 572 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM3(1), DLG4(4), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), NOS1(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), SYT1(3) 6975540 39 30 39 21 9 15 5 3 7 0 0.937 1.000 1.000 573 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(4), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3B(5), POLR3D(2), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(2) 9508564 37 30 37 17 9 8 6 4 10 0 0.934 1.000 1.000 574 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(8), DBH(1), DDC(2), GAD1(3), GAD2(2), HDC(2), MAOA(2), PAH(4), SLC18A3(1), TH(3), TPH1(2) 4008353 33 29 33 14 13 11 2 3 4 0 0.662 1.000 1.000 575 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(3), ACE2(3), AGT(1), AGTR2(2), ANPEP(1), CMA1(1), CPA3(2), ENPEP(4), LNPEP(3), MAS1(1), MME(4), NLN(3), REN(2), THOP1(1) 5721276 31 29 31 13 4 15 2 3 7 0 0.781 1.000 1.000 576 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(4), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TRAF3(1) 8166774 33 29 32 17 10 9 3 6 5 0 0.935 1.000 1.000 577 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(4), EGFR(5), IGF1R(4), POLR2A(3), PPP2CA(1), PRKCA(1), RB1(8), TEP1(2), TERF1(2), TERT(2), TNKS(2), XRCC5(4) 7480712 38 29 37 14 6 13 5 0 14 0 0.767 1.000 1.000 578 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(4), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NFKB1(2), PIK3R1(5), RB1(8), SP1(1) 4818166 35 28 35 13 8 6 4 1 16 0 0.855 1.000 1.000 579 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(3), B3GAT2(2), B4GALT7(3), CHPF(4), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST7(1), CHSY1(3), DSE(3), XYLT1(3), XYLT2(3) 3879819 30 28 30 15 15 7 0 5 3 0 0.878 1.000 1.000 580 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(8), ARHGEF1(3), GNA12(1), GNA13(3), GNAQ(1), GNGT1(1), MYLK(6), PLCB1(3), PPP1R12B(1), PRKCA(1), ROCK1(2) 5736940 30 28 30 14 3 11 10 3 3 0 0.898 1.000 1.000 581 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT2(2), GALNT3(2), GALNT7(2), GALNT8(5), GALNT9(3), GCNT1(3), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), WBSCR17(10) 4052521 34 28 34 12 8 8 10 6 2 0 0.696 1.000 1.000 582 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), ARSB(2), ARSD(1), CYP11B1(2), CYP11B2(4), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1) 7425573 31 27 31 12 8 12 4 4 3 0 0.685 1.000 1.000 583 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CYP2C9(4), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), HADHA(2), SH3GLB1(2), YOD1(1) 8237049 31 27 31 10 8 12 2 2 7 0 0.645 1.000 1.000 584 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), APOA1(1), APOA4(1), APOC2(1), APOC3(3), APOE(1), HMGCR(1), LCAT(1), LDLR(3), LPL(2), LRP1(8), SCARB1(3), SOAT1(1) 7492972 33 27 33 10 10 13 2 2 6 0 0.288 1.000 1.000 585 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), CSNK1D(1), DRD1(3), DRD2(4), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKAR1B(2), PRKAR2B(3) 4290671 29 26 29 11 7 12 2 3 5 0 0.597 1.000 1.000 586 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(4), HRAS(1), MAPK1(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), NTRK1(5), PIK3R1(5), PLCG1(5), RPS6KA1(1) 4789920 29 26 29 10 10 7 2 2 8 0 0.590 1.000 1.000 587 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), NAGLU(3), SPAM1(1) 5761800 30 26 30 11 6 11 4 4 5 0 0.642 1.000 1.000 588 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(2), ENPP1(5), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5M(1) 3981039 26 26 26 10 0 15 0 5 6 0 0.802 1.000 1.000 589 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(3), ITGB1(1), L1CAM(4), LYN(2), SELP(3) 4270739 27 24 27 15 5 13 4 2 3 0 0.918 1.000 1.000 590 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPOR(2), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAPK8(1), PLCG1(5), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2) 6091421 28 24 28 10 9 10 2 3 4 0 0.619 1.000 1.000 591 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), IFNG(1), IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(2), NFKB1(2), RB1(8), TNFRSF1B(1), WT1(4) 4868131 26 24 26 11 6 5 2 2 11 0 0.851 1.000 1.000 592 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(9), FASN(7), OXSM(1) 4516159 25 23 25 14 6 8 3 3 5 0 0.914 1.000 1.000 593 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(2), LEPR(4), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1) 3968022 23 23 23 10 3 12 4 2 2 0 0.845 1.000 1.000 594 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTR(7) 4851690 26 23 26 10 7 10 1 5 3 0 0.665 1.000 1.000 595 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4) 4509704 26 23 26 10 3 15 5 0 3 0 0.685 1.000 1.000 596 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(4), AKT2(1), AKT3(2), ILK(2), MAPK1(1), PIK3CD(5), PTK2B(4), RBL2(4), SOS1(3) 4677106 26 23 26 12 5 9 2 4 6 0 0.896 1.000 1.000 597 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(2), IARS(4), IARS2(1), ILVBL(1), LARS(4), LARS2(2), PDHA2(5), VARS(2), VARS2(2) 5058240 23 22 23 10 6 7 4 3 3 0 0.802 1.000 1.000 598 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(3), GLB1(2), LCT(8), SLC33A1(2), ST3GAL1(2), ST3GAL2(2), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1) 4385856 25 22 25 10 7 7 6 3 2 0 0.729 1.000 1.000 599 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), SELE(3), SELL(1), SELP(3) 4488002 23 22 22 13 3 11 2 2 5 0 0.933 1.000 1.000 600 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CD28(1), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL4R(3), TGFB2(1), TGFB3(2) 5483732 27 22 26 12 6 8 3 7 3 0 0.821 1.000 1.000 601 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD1(5), PSMD11(1), PSMD12(2), PSMD2(2), PSMD6(1) 4416957 23 21 23 10 4 10 4 2 3 0 0.840 1.000 1.000 602 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(4), HRAS(1), IGF1R(4), IRS1(6), MAP2K1(2), MAPK1(1), PIK3R1(5), RAF1(2), SOS1(3) 4581882 28 21 28 10 7 5 5 3 8 0 0.767 1.000 1.000 603 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(1), HRAS(1), IL3(2), IL3RA(1), JAK2(2), MAP2K1(2), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2) 4957079 25 21 25 10 8 7 2 4 4 0 0.674 1.000 1.000 604 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9) 4567107 24 20 24 14 3 7 2 6 6 0 0.980 1.000 1.000 605 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2) 6622347 21 19 21 10 6 7 2 1 5 0 0.890 1.000 1.000 606 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(8), PCYT1A(2), PDHA2(5), SLC18A3(1) 1894261 19 18 19 13 7 7 3 0 2 0 0.956 1.000 1.000 607 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1) 3623754 20 17 20 11 9 6 0 2 3 0 0.901 1.000 1.000 608 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(4), GH1(1), GHR(2), HRAS(1), IGF1(1), IGF1R(4), PIK3R1(5) 2997606 18 17 18 10 4 3 5 0 6 0 0.952 1.000 1.000 609 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), TBXA2R(2) 3017117 18 17 18 10 4 5 2 4 3 0 0.835 1.000 1.000 610 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(5), ITGAL(6), ITGB1(1), SELE(3), SELL(1) 3397097 17 16 16 11 2 8 2 2 3 0 0.958 1.000 1.000 611 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(1), ALPP(5), FPGS(1), SPR(1) 1878234 8 8 8 10 2 3 0 1 2 0 0.993 1.000 1.000 612 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST12(1), CHST13(1), PAPSS2(3), SULT1A1(1), SULT2B1(1), SUOX(1) 2550304 8 8 8 11 3 3 2 0 0 0 0.999 1.000 1.000 613 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(3), SUOX(1) 1626586 4 4 4 5 0 2 2 0 0 0 0.990 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 456615 2 2 2 2 2 0 0 0 0 0 0.921 1.000 1.000 615 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 1385008 2 2 2 3 1 1 0 0 0 0 0.958 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 139243 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000