Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.025 0.03 -9999.0 0.0 -0.133 23.0 23.0 epithelial cell differentiation 0.06 0.032 -9999.0 0.0 -0.049 18.0 18.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.045 0.052 0.406 4.0 -9999.0 0.0 4.0 EGFR 0.012 0.018 -9999.0 0.0 -0.07 5.0 5.0 EPHA2 0.029 0.016 -9999.0 0.0 -0.07 12.0 12.0 MYO6 -0.029 0.03 0.165 11.0 -9999.0 0.0 11.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.039 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.013 0.044 0.162 8.0 -0.315 7.0 15.0 CTNND1 0.03 0.015 -9999.0 0.0 -0.07 10.0 10.0 mol:PI-4-5-P2 -0.03 0.025 0.161 7.0 -9999.0 0.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.03 0.163 11.0 -9999.0 0.0 11.0 EGF 0.032 0.007 -9999.0 0.0 -0.07 2.0 2.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.03 0.077 0.163 5.0 -0.317 31.0 36.0 cortical microtubule organization 0.06 0.032 -9999.0 0.0 -0.049 18.0 18.0 GO:0000145 -0.028 0.023 0.146 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.066 0.034 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.016 -9999.0 0.0 -0.106 2.0 2.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.067 0.043 -9999.0 0.0 -0.078 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.025 0.154 3.0 -0.192 1.0 4.0 PVRL2 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.027 0.16 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.069 0.051 -9999.0 0.0 -0.079 7.0 7.0 CDH1 0.03 0.013 -9999.0 0.0 -0.07 8.0 8.0 EGFR/EGFR/EGF/EGF 0.019 0.035 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.061 0.034 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.024 0.027 0.143 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.031 0.01 -9999.0 0.0 -0.07 4.0 4.0 DIAPH1 -0.213 0.259 -9999.0 0.0 -0.453 262.0 262.0 Wnt receptor signaling pathway -0.06 0.032 0.049 18.0 -9999.0 0.0 18.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.017 -9999.0 0.0 -0.106 2.0 2.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.024 0.027 0.144 8.0 -9999.0 0.0 8.0 EFNA1 0.028 0.021 -9999.0 0.0 -0.07 21.0 21.0 LPP -0.035 0.025 0.149 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.046 0.042 -9999.0 0.0 -0.076 8.0 8.0 SEC6/SEC8 -0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.029 0.03 0.165 11.0 -9999.0 0.0 11.0 HGF/MET 0.034 0.038 -9999.0 0.0 -0.077 1.0 1.0 HGF 0.022 0.016 -9999.0 0.0 -0.07 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.025 0.031 -9999.0 0.0 -0.134 23.0 23.0 actin cable formation -0.039 0.075 0.322 11.0 -0.212 11.0 22.0 KIAA1543 -0.024 0.024 0.149 9.0 -9999.0 0.0 9.0 KIFC3 -0.031 0.026 0.165 8.0 -9999.0 0.0 8.0 NCK1 0.029 0.016 -9999.0 0.0 -0.07 11.0 11.0 EXOC3 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.029 0.164 9.0 -9999.0 0.0 9.0 NCK1/GIT1 0.044 0.017 -9999.0 0.0 -0.054 11.0 11.0 mol:GDP 0.06 0.032 -9999.0 0.0 -0.049 18.0 18.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.031 0.028 0.164 10.0 -9999.0 0.0 10.0 PIP5K1C -0.03 0.025 0.162 7.0 -9999.0 0.0 7.0 LIMA1 -0.054 0.036 -9999.0 0.0 -0.07 425.0 425.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.042 0.066 0.41 7.0 -9999.0 0.0 7.0 adherens junction assembly -0.022 0.043 0.212 5.0 -0.203 9.0 14.0 IGF-1R heterotetramer/IGF1 0.052 0.035 -9999.0 0.0 -0.077 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.016 -9999.0 0.0 -0.07 2.0 2.0 PLEKHA7 -0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.064 0.042 -9999.0 0.0 -0.059 33.0 33.0 establishment of epithelial cell apical/basal polarity -0.04 0.043 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.025 0.03 -9999.0 0.0 -0.133 23.0 23.0 regulation of cell-cell adhesion -0.024 0.027 0.143 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.025 0.031 -9999.0 0.0 -0.134 23.0 23.0