This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Testing the association between mutation status of 171 genes and 9 clinical features across 795 patients, 91 significant findings detected with Q value < 0.25.
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IDH1 mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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TP53 mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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ATRX mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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CIC mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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NF1 mutation correlated to 'Time to Death' and 'YEARS_TO_BIRTH'.
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PIK3R1 mutation correlated to 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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NOTCH1 mutation correlated to 'Time to Death', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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IDH2 mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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RB1 mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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FUBP1 mutation correlated to 'Time to Death', 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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PTEN mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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ARID1A mutation correlated to 'Time to Death', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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NIPBL mutation correlated to 'Time to Death'.
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NUDT11 mutation correlated to 'TUMOR_TISSUE_SITE'.
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PLCG1 mutation correlated to 'Time to Death' and 'YEARS_TO_BIRTH'.
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PDGFRA mutation correlated to 'Time to Death'.
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STAG2 mutation correlated to 'TUMOR_TISSUE_SITE'.
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REN mutation correlated to 'Time to Death'.
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HTRA2 mutation correlated to 'YEARS_TO_BIRTH'.
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BRAF mutation correlated to 'HISTOLOGICAL_TYPE'.
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MX2 mutation correlated to 'YEARS_TO_BIRTH'.
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EGFR mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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WRN mutation correlated to 'ETHNICITY'.
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ZNF41 mutation correlated to 'GENDER'.
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ATF7IP2 mutation correlated to 'KARNOFSKY_PERFORMANCE_SCORE'.
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ZBTB20 mutation correlated to 'TUMOR_TISSUE_SITE' and 'HISTOLOGICAL_TYPE'.
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PDHA1 mutation correlated to 'GENDER'.
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FAM123C mutation correlated to 'YEARS_TO_BIRTH'.
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DNMT3A mutation correlated to 'Time to Death' and 'TUMOR_TISSUE_SITE'.
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QKI mutation correlated to 'Time to Death'.
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SMARCA4 mutation correlated to 'Time to Death', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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GRHL3 mutation correlated to 'GENDER'.
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TNFRSF9 mutation correlated to 'KARNOFSKY_PERFORMANCE_SCORE'.
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PASD1 mutation correlated to 'GENDER'.
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IL4R mutation correlated to 'Time to Death', 'YEARS_TO_BIRTH', and 'TUMOR_TISSUE_SITE'.
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GABRA6 mutation correlated to 'TUMOR_TISSUE_SITE'.
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AK7 mutation correlated to 'Time to Death'.
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DSP mutation correlated to 'YEARS_TO_BIRTH'.
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PAN3 mutation correlated to 'TUMOR_TISSUE_SITE'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
TUMOR TISSUE SITE |
GENDER |
RADIATION THERAPY |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
RACE | ETHNICITY | ||
nMutated (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
IDH1 | 414 (52%) | 381 |
0 (0) |
3.8e-55 (1.17e-52) |
1.34e-97 (5.16e-95) |
0.172 (0.715) |
2.67e-08 (1.96e-06) |
1.89e-16 (2.65e-14) |
1e-05 (0.000481) |
0.0597 (0.503) |
0.0542 (0.482) |
TP53 | 330 (42%) | 465 |
8.87e-10 (8.03e-08) |
9.18e-19 (1.41e-16) |
5.04e-08 (3.53e-06) |
1 (1.00) |
0.005 (0.108) |
0.00118 (0.0343) |
1e-05 (0.000481) |
0.283 (0.844) |
0.294 (0.855) |
CIC | 109 (14%) | 686 |
1.84e-12 (1.77e-10) |
0.00112 (0.0334) |
2.84e-21 (4.85e-19) |
0.117 (0.624) |
2.15e-09 (1.74e-07) |
0.000469 (0.0154) |
1e-05 (0.000481) |
0.66 (1.00) |
0.216 (0.785) |
EGFR | 108 (14%) | 687 |
0 (0) |
1.9e-14 (2.09e-12) |
2.5e-13 (2.56e-11) |
0.172 (0.715) |
0.0017 (0.0468) |
2.1e-05 (0.000949) |
1e-05 (0.000481) |
0.0504 (0.47) |
0.109 (0.609) |
ATRX | 213 (27%) | 582 |
5.77e-15 (7.4e-13) |
6.85e-34 (1.76e-31) |
1.48e-26 (3.26e-24) |
0.516 (0.998) |
0.657 (1.00) |
0.000108 (0.00448) |
1e-05 (0.000481) |
0.925 (1.00) |
0.44 (0.955) |
FUBP1 | 47 (6%) | 748 |
0.000234 (0.00856) |
0.43 (0.947) |
1.03e-09 (8.8e-08) |
1 (1.00) |
0.00374 (0.0913) |
0.0102 (0.184) |
1e-05 (0.000481) |
1 (1.00) |
0.262 (0.83) |
PTEN | 110 (14%) | 685 |
0 (0) |
1.74e-14 (2.07e-12) |
4.34e-23 (8.36e-21) |
0.467 (0.96) |
0.0639 (0.504) |
0.0017 (0.0468) |
1e-05 (0.000481) |
0.483 (0.971) |
0.607 (1.00) |
IDH2 | 20 (3%) | 775 |
0.00169 (0.0468) |
0.000505 (0.0162) |
0.000192 (0.00722) |
0.82 (1.00) |
0.135 (0.657) |
0.121 (0.635) |
3e-05 (0.00132) |
0.491 (0.971) |
0.0627 (0.504) |
RB1 | 30 (4%) | 765 |
0.0105 (0.187) |
0.000292 (0.0105) |
4.04e-07 (2.71e-05) |
1 (1.00) |
0.304 (0.864) |
0.484 (0.971) |
1e-05 (0.000481) |
1 (1.00) |
0.634 (1.00) |
PIK3R1 | 54 (7%) | 741 |
0.157 (0.705) |
0.00293 (0.0739) |
0.000307 (0.0107) |
0.0853 (0.55) |
0.158 (0.705) |
0.13 (0.651) |
0.00448 (0.101) |
0.126 (0.65) |
0.159 (0.705) |
NOTCH1 | 42 (5%) | 753 |
0.000471 (0.0154) |
0.248 (0.809) |
1.1e-08 (8.44e-07) |
0.426 (0.947) |
0.0824 (0.549) |
0.207 (0.764) |
1e-05 (0.000481) |
0.31 (0.872) |
1 (1.00) |
ARID1A | 22 (3%) | 773 |
0.00409 (0.0979) |
0.0158 (0.251) |
0.0108 (0.187) |
0.388 (0.92) |
0.162 (0.712) |
0.268 (0.834) |
0.00538 (0.113) |
0.747 (1.00) |
1 (1.00) |
SMARCA4 | 27 (3%) | 768 |
0.000115 (0.00467) |
0.134 (0.657) |
0.000137 (0.00541) |
0.431 (0.947) |
0.661 (1.00) |
0.08 (0.549) |
0.00603 (0.125) |
0.0897 (0.566) |
0.28 (0.844) |
IL4R | 10 (1%) | 785 |
6.81e-05 (0.00291) |
0.000403 (0.0138) |
0.0048 (0.107) |
0.0201 (0.285) |
1 (1.00) |
0.0526 (0.476) |
0.102 (0.596) |
0.501 (0.978) |
1 (1.00) |
NF1 | 62 (8%) | 733 |
1.07e-05 (0.000501) |
0.000558 (0.0175) |
0.0529 (0.476) |
0.688 (1.00) |
0.658 (1.00) |
0.0482 (0.458) |
0.0235 (0.304) |
0.685 (1.00) |
0.325 (0.877) |
PLCG1 | 11 (1%) | 784 |
0.00257 (0.0659) |
0.0117 (0.199) |
0.531 (1.00) |
1 (1.00) |
0.187 (0.718) |
0.79 (1.00) |
0.579 (1.00) |
0.534 (1.00) |
1 (1.00) |
ZBTB20 | 22 (3%) | 773 |
0.0261 (0.329) |
0.211 (0.773) |
0.00113 (0.0334) |
0.388 (0.92) |
0.0524 (0.476) |
0.352 (0.893) |
0.00747 (0.146) |
0.157 (0.705) |
0.28 (0.844) |
DNMT3A | 11 (1%) | 784 |
0.00429 (0.0986) |
0.336 (0.877) |
0.0101 (0.184) |
0.77 (1.00) |
1 (1.00) |
0.336 (0.877) |
0.0293 (0.346) |
0.533 (1.00) |
0.431 (0.947) |
NIPBL | 20 (3%) | 775 |
0.00485 (0.107) |
0.0157 (0.251) |
0.0166 (0.256) |
0.649 (1.00) |
0.118 (0.624) |
0.0889 (0.565) |
0.0315 (0.354) |
0.09 (0.566) |
0.0713 (0.541) |
NUDT11 | 11 (1%) | 784 |
0.0854 (0.55) |
0.567 (1.00) |
0.0101 (0.184) |
0.377 (0.917) |
0.747 (1.00) |
0.178 (0.715) |
0.0761 (0.548) |
1 (1.00) |
1 (1.00) |
PDGFRA | 21 (3%) | 774 |
0.00428 (0.0986) |
0.0713 (0.541) |
0.108 (0.609) |
0.656 (1.00) |
1 (1.00) |
0.015 (0.25) |
0.182 (0.715) |
0.743 (1.00) |
0.261 (0.829) |
STAG2 | 16 (2%) | 779 |
0.0301 (0.351) |
0.0865 (0.554) |
0.00213 (0.0566) |
0.61 (1.00) |
0.591 (1.00) |
0.0292 (0.346) |
0.0175 (0.261) |
0.649 (1.00) |
1 (1.00) |
REN | 7 (1%) | 788 |
0.000159 (0.00611) |
0.0776 (0.549) |
0.103 (0.596) |
0.249 (0.81) |
0.445 (0.955) |
0.37 (0.902) |
0.0309 (0.352) |
1 (1.00) |
1 (1.00) |
HTRA2 | 5 (1%) | 790 |
0.222 (0.792) |
0.00731 (0.146) |
0.168 (0.712) |
1 (1.00) |
0.311 (0.872) |
0.179 (0.715) |
1 (1.00) |
0.225 (0.792) |
|
BRAF | 11 (1%) | 784 |
0.929 (1.00) |
0.549 (1.00) |
0.208 (0.769) |
1 (1.00) |
0.287 (0.844) |
0.481 (0.969) |
0.00312 (0.0774) |
0.5 (0.978) |
1 (1.00) |
MX2 | 9 (1%) | 786 |
0.391 (0.925) |
0.0145 (0.245) |
0.291 (0.85) |
1 (1.00) |
1 (1.00) |
0.263 (0.83) |
0.0867 (0.554) |
0.465 (0.959) |
1 (1.00) |
WRN | 6 (1%) | 789 |
0.0729 (0.541) |
0.363 (0.902) |
0.671 (1.00) |
0.241 (0.801) |
1 (1.00) |
0.135 (0.657) |
0.585 (1.00) |
0.339 (0.878) |
0.00202 (0.0545) |
ZNF41 | 8 (1%) | 787 |
0.113 (0.615) |
0.965 (1.00) |
0.719 (1.00) |
0.0107 (0.187) |
0.063 (0.504) |
0.36 (0.897) |
0.278 (0.844) |
0.1 (0.594) |
1 (1.00) |
ATF7IP2 | 8 (1%) | 787 |
0.0848 (0.55) |
0.194 (0.731) |
0.138 (0.661) |
1 (1.00) |
0.445 (0.955) |
0.00992 (0.184) |
0.64 (1.00) |
0.0264 (0.33) |
1 (1.00) |
PDHA1 | 6 (1%) | 789 |
0.648 (1.00) |
0.469 (0.96) |
0.671 (1.00) |
0.00507 (0.108) |
0.178 (0.715) |
0.0502 (0.47) |
0.315 (0.872) |
1 (1.00) |
1 (1.00) |
FAM123C | 11 (1%) | 784 |
0.0466 (0.448) |
0.00254 (0.0659) |
0.0587 (0.499) |
0.0307 (0.352) |
0.036 (0.387) |
0.347 (0.893) |
0.194 (0.731) |
0.533 (1.00) |
1 (1.00) |
QKI | 6 (1%) | 789 |
0.00714 (0.145) |
0.279 (0.844) |
0.0226 (0.302) |
0.697 (1.00) |
0.672 (1.00) |
0.278 (0.844) |
0.144 (0.678) |
1 (1.00) |
1 (1.00) |
GRHL3 | 8 (1%) | 787 |
0.363 (0.902) |
0.708 (1.00) |
0.462 (0.955) |
0.000859 (0.0264) |
0.382 (0.92) |
0.412 (0.942) |
0.426 (0.947) |
1 (1.00) |
|
TNFRSF9 | 4 (1%) | 791 |
0.81 (1.00) |
0.181 (0.715) |
1 (1.00) |
0.313 (0.872) |
1 (1.00) |
0.00962 (0.183) |
0.921 (1.00) |
0.242 (0.801) |
1 (1.00) |
PASD1 | 8 (1%) | 787 |
0.617 (1.00) |
0.893 (1.00) |
0.462 (0.955) |
0.0107 (0.187) |
0.683 (1.00) |
0.781 (1.00) |
0.389 (0.92) |
1 (1.00) |
1 (1.00) |
GABRA6 | 15 (2%) | 780 |
0.112 (0.615) |
0.0229 (0.302) |
0.00414 (0.0979) |
0.793 (1.00) |
0.117 (0.624) |
0.0283 (0.341) |
0.0417 (0.422) |
1 (1.00) |
1 (1.00) |
AK7 | 8 (1%) | 787 |
0.00746 (0.146) |
0.54 (1.00) |
0.462 (0.955) |
1 (1.00) |
0.446 (0.955) |
0.496 (0.976) |
0.217 (0.786) |
0.423 (0.947) |
0.336 (0.877) |
DSP | 20 (3%) | 775 |
0.655 (1.00) |
0.00655 (0.134) |
0.0939 (0.583) |
0.495 (0.975) |
0.454 (0.955) |
0.567 (1.00) |
0.324 (0.877) |
0.715 (1.00) |
0.604 (1.00) |
PAN3 | 7 (1%) | 788 |
0.365 (0.902) |
0.263 (0.83) |
0.00906 (0.174) |
1 (1.00) |
1 (1.00) |
0.0599 (0.503) |
0.0841 (0.549) |
1 (1.00) |
1 (1.00) |
TCF12 | 19 (2%) | 776 |
0.24 (0.801) |
0.678 (1.00) |
0.231 (0.801) |
0.643 (1.00) |
1 (1.00) |
0.956 (1.00) |
0.26 (0.829) |
0.733 (1.00) |
0.617 (1.00) |
PIK3CA | 70 (9%) | 725 |
0.321 (0.877) |
0.196 (0.735) |
0.793 (1.00) |
1 (1.00) |
0.497 (0.977) |
0.379 (0.92) |
0.113 (0.615) |
0.546 (1.00) |
1 (1.00) |
STK19 | 11 (1%) | 784 |
0.223 (0.792) |
0.114 (0.615) |
0.108 (0.609) |
0.216 (0.785) |
0.683 (1.00) |
0.257 (0.828) |
0.0719 (0.541) |
1 (1.00) |
0.0992 (0.592) |
ZMIZ1 | 12 (2%) | 783 |
0.152 (0.698) |
0.235 (0.801) |
0.555 (1.00) |
0.568 (1.00) |
1 (1.00) |
0.359 (0.897) |
0.674 (1.00) |
0.118 (0.624) |
0.0181 (0.265) |
GAGE2A | 8 (1%) | 787 |
0.136 (0.657) |
0.258 (0.828) |
0.056 (0.491) |
1 (1.00) |
0.683 (1.00) |
0.834 (1.00) |
0.218 (0.786) |
0.0568 (0.491) |
0.336 (0.877) |
CREBZF | 9 (1%) | 786 |
0.337 (0.878) |
0.321 (0.877) |
0.505 (0.982) |
0.502 (0.978) |
1 (1.00) |
0.8 (1.00) |
0.132 (0.657) |
0.0709 (0.541) |
0.369 (0.902) |
SLC26A3 | 11 (1%) | 784 |
0.451 (0.955) |
0.283 (0.844) |
0.0587 (0.499) |
0.134 (0.657) |
0.063 (0.504) |
0.045 (0.438) |
0.0326 (0.36) |
0.535 (1.00) |
1 (1.00) |
SEMG1 | 11 (1%) | 784 |
0.593 (1.00) |
0.0158 (0.251) |
0.0204 (0.285) |
1 (1.00) |
0.728 (1.00) |
0.89 (1.00) |
0.0613 (0.504) |
0.536 (1.00) |
1 (1.00) |
NUP210L | 12 (2%) | 783 |
0.946 (1.00) |
0.712 (1.00) |
0.0308 (0.352) |
1 (1.00) |
0.187 (0.718) |
0.742 (1.00) |
0.0156 (0.251) |
0.565 (1.00) |
1 (1.00) |
MED9 | 3 (0%) | 792 |
0.861 (1.00) |
0.411 (0.942) |
0.556 (1.00) |
0.27 (0.835) |
0.556 (1.00) |
0.0324 (0.36) |
1 (1.00) |
1 (1.00) |
|
NKD2 | 4 (1%) | 791 |
0.367 (0.902) |
0.746 (1.00) |
0.303 (0.864) |
1 (1.00) |
0.092 (0.573) |
0.173 (0.715) |
1 (1.00) |
1 (1.00) |
|
IRS4 | 11 (1%) | 784 |
0.0567 (0.491) |
0.984 (1.00) |
0.755 (1.00) |
0.77 (1.00) |
1 (1.00) |
0.408 (0.942) |
0.266 (0.833) |
1 (1.00) |
0.0837 (0.549) |
MUC17 | 50 (6%) | 745 |
0.259 (0.829) |
0.0405 (0.415) |
0.221 (0.79) |
0.555 (1.00) |
0.744 (1.00) |
0.824 (1.00) |
0.568 (1.00) |
0.474 (0.965) |
1 (1.00) |
RPL5 | 10 (1%) | 785 |
0.951 (1.00) |
0.0267 (0.331) |
0.0388 (0.412) |
0.334 (0.877) |
0.0637 (0.504) |
0.0756 (0.548) |
0.189 (0.72) |
0.147 (0.687) |
1 (1.00) |
KDR | 13 (2%) | 782 |
0.489 (0.971) |
0.0542 (0.482) |
0.0741 (0.541) |
1 (1.00) |
0.359 (0.897) |
0.592 (1.00) |
0.129 (0.65) |
1 (1.00) |
1 (1.00) |
RBPJ | 7 (1%) | 788 |
0.302 (0.864) |
0.625 (1.00) |
0.0562 (0.491) |
1 (1.00) |
0.382 (0.92) |
0.583 (1.00) |
0.0953 (0.584) |
1 (1.00) |
1 (1.00) |
NRAS | 5 (1%) | 790 |
0.537 (1.00) |
0.834 (1.00) |
0.662 (1.00) |
1 (1.00) |
0.178 (0.715) |
0.544 (1.00) |
0.134 (0.657) |
1 (1.00) |
1 (1.00) |
TRERF1 | 7 (1%) | 788 |
0.118 (0.624) |
0.242 (0.801) |
0.431 (0.947) |
0.023 (0.302) |
0.683 (1.00) |
0.549 (1.00) |
0.18 (0.715) |
1 (1.00) |
1 (1.00) |
BCOR | 22 (3%) | 773 |
0.456 (0.955) |
0.444 (0.955) |
0.824 (1.00) |
0.273 (0.838) |
1 (1.00) |
0.344 (0.888) |
0.0991 (0.592) |
1 (1.00) |
1 (1.00) |
PTPN11 | 11 (1%) | 784 |
0.276 (0.844) |
0.0904 (0.566) |
1 (1.00) |
0.77 (1.00) |
1 (1.00) |
0.461 (0.955) |
0.572 (1.00) |
0.501 (0.978) |
1 (1.00) |
FAM47C | 24 (3%) | 771 |
0.0382 (0.409) |
0.697 (1.00) |
0.192 (0.727) |
0.0974 (0.588) |
0.487 (0.971) |
0.234 (0.801) |
0.609 (1.00) |
0.756 (1.00) |
1 (1.00) |
DDX5 | 9 (1%) | 786 |
0.699 (1.00) |
0.194 (0.731) |
0.727 (1.00) |
0.318 (0.873) |
1 (1.00) |
0.152 (0.698) |
0.0222 (0.302) |
1 (1.00) |
0.336 (0.877) |
SETD2 | 13 (2%) | 782 |
0.571 (1.00) |
0.153 (0.7) |
0.559 (1.00) |
0.574 (1.00) |
0.764 (1.00) |
0.221 (0.79) |
0.542 (1.00) |
0.594 (1.00) |
1 (1.00) |
ZNF709 | 5 (1%) | 790 |
0.904 (1.00) |
0.68 (1.00) |
1 (1.00) |
0.0794 (0.549) |
1 (1.00) |
0.352 (0.893) |
0.635 (1.00) |
0.294 (0.855) |
1 (1.00) |
FAM126B | 8 (1%) | 787 |
0.875 (1.00) |
0.491 (0.971) |
0.462 (0.955) |
1 (1.00) |
1 (1.00) |
0.407 (0.942) |
0.551 (1.00) |
1 (1.00) |
0.301 (0.864) |
MYST4 | 12 (2%) | 783 |
0.042 (0.422) |
0.695 (1.00) |
0.0656 (0.512) |
1 (1.00) |
1 (1.00) |
0.783 (1.00) |
0.113 (0.615) |
0.197 (0.736) |
0.401 (0.942) |
TLR6 | 8 (1%) | 787 |
0.529 (1.00) |
0.148 (0.687) |
0.138 (0.661) |
0.725 (1.00) |
0.063 (0.504) |
0.122 (0.635) |
0.282 (0.844) |
0.1 (0.594) |
1 (1.00) |
ACADS | 5 (1%) | 790 |
0.304 (0.864) |
0.0259 (0.329) |
0.351 (0.893) |
0.408 (0.942) |
0.332 (0.877) |
0.903 (1.00) |
0.465 (0.959) |
1 (1.00) |
1 (1.00) |
TNRC18 | 12 (2%) | 783 |
0.0759 (0.548) |
0.387 (0.92) |
0.231 (0.801) |
0.137 (0.66) |
0.359 (0.897) |
0.851 (1.00) |
0.385 (0.92) |
0.566 (1.00) |
1 (1.00) |
SLC6A3 | 12 (2%) | 783 |
0.997 (1.00) |
0.922 (1.00) |
0.555 (1.00) |
0.253 (0.817) |
0.332 (0.877) |
0.237 (0.801) |
0.749 (1.00) |
1 (1.00) |
0.369 (0.902) |
ZNF292 | 17 (2%) | 778 |
0.555 (1.00) |
0.128 (0.65) |
0.198 (0.738) |
0.0225 (0.302) |
0.108 (0.609) |
0.845 (1.00) |
0.596 (1.00) |
0.209 (0.771) |
0.561 (1.00) |
ARID2 | 13 (2%) | 782 |
0.118 (0.624) |
0.664 (1.00) |
0.155 (0.704) |
0.782 (1.00) |
0.359 (0.897) |
0.359 (0.897) |
0.257 (0.828) |
0.319 (0.873) |
0.487 (0.971) |
KRTAP5-3 | 4 (1%) | 791 |
0.129 (0.65) |
0.897 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.922 (1.00) |
0.244 (0.801) |
1 (1.00) |
|
SRPX | 4 (1%) | 791 |
0.94 (1.00) |
0.382 (0.92) |
0.303 (0.864) |
0.0297 (0.349) |
1 (1.00) |
0.427 (0.947) |
0.157 (0.705) |
0.244 (0.801) |
1 (1.00) |
NEU2 | 9 (1%) | 786 |
0.762 (1.00) |
0.756 (1.00) |
1 (1.00) |
1 (1.00) |
0.728 (1.00) |
0.419 (0.947) |
0.624 (1.00) |
1 (1.00) |
0.336 (0.877) |
TMEM216 | 3 (0%) | 792 |
0.517 (0.999) |
0.485 (0.971) |
0.556 (1.00) |
0.0718 (0.541) |
0.526 (1.00) |
0.18 (0.715) |
1 (1.00) |
1 (1.00) |
|
KTELC1 | 5 (1%) | 790 |
0.102 (0.596) |
0.53 (1.00) |
0.168 (0.712) |
0.408 (0.942) |
1 (1.00) |
0.24 (0.801) |
1 (1.00) |
1 (1.00) |
|
SOX4 | 7 (1%) | 788 |
0.0196 (0.282) |
0.768 (1.00) |
0.431 (0.947) |
0.459 (0.955) |
1 (1.00) |
0.628 (1.00) |
1 (1.00) |
0.0429 (0.423) |
|
SERPING1 | 4 (1%) | 791 |
0.915 (1.00) |
0.0904 (0.566) |
1 (1.00) |
0.645 (1.00) |
1 (1.00) |
0.116 (0.624) |
0.923 (1.00) |
1 (1.00) |
1 (1.00) |
RASGRF2 | 6 (1%) | 789 |
0.119 (0.626) |
0.331 (0.877) |
1 (1.00) |
0.697 (1.00) |
0.185 (0.715) |
0.71 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
FAM83D | 6 (1%) | 789 |
0.734 (1.00) |
0.267 (0.833) |
1 (1.00) |
0.697 (1.00) |
0.332 (0.877) |
0.352 (0.893) |
0.702 (1.00) |
0.341 (0.882) |
1 (1.00) |
ZNF512B | 5 (1%) | 790 |
0.0284 (0.341) |
0.0816 (0.549) |
0.168 (0.712) |
1 (1.00) |
1 (1.00) |
0.38 (0.92) |
1 (1.00) |
0.225 (0.792) |
|
TPX2 | 7 (1%) | 788 |
0.134 (0.657) |
0.767 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.544 (1.00) |
1 (1.00) |
1 (1.00) |
0.0429 (0.423) |
C10ORF76 | 4 (1%) | 791 |
0.318 (0.873) |
0.486 (0.971) |
1 (1.00) |
1 (1.00) |
0.316 (0.872) |
0.843 (1.00) |
1 (1.00) |
1 (1.00) |
|
TRPV6 | 13 (2%) | 782 |
0.969 (1.00) |
0.925 (1.00) |
0.239 (0.801) |
0.404 (0.942) |
0.764 (1.00) |
0.422 (0.947) |
0.67 (1.00) |
0.134 (0.657) |
1 (1.00) |
ZDHHC4 | 4 (1%) | 791 |
0.811 (1.00) |
0.336 (0.877) |
0.128 (0.65) |
0.313 (0.872) |
0.556 (1.00) |
0.0826 (0.549) |
0.243 (0.801) |
1 (1.00) |
|
CPEB4 | 7 (1%) | 788 |
0.0818 (0.549) |
0.48 (0.968) |
0.431 (0.947) |
1 (1.00) |
0.683 (1.00) |
0.388 (0.92) |
0.518 (0.999) |
0.157 (0.705) |
1 (1.00) |
EEF1A1 | 8 (1%) | 787 |
0.406 (0.942) |
0.0394 (0.412) |
0.462 (0.955) |
0.288 (0.846) |
1 (1.00) |
0.112 (0.615) |
0.889 (1.00) |
1 (1.00) |
1 (1.00) |
PROKR2 | 9 (1%) | 786 |
0.0219 (0.301) |
0.0187 (0.271) |
0.0738 (0.541) |
0.742 (1.00) |
0.728 (1.00) |
0.479 (0.968) |
0.272 (0.837) |
1 (1.00) |
1 (1.00) |
TMEM184A | 3 (0%) | 792 |
0.188 (0.718) |
0.476 (0.967) |
0.556 (1.00) |
1 (1.00) |
1 (1.00) |
0.503 (0.978) |
0.186 (0.718) |
1 (1.00) |
|
G6PC | 7 (1%) | 788 |
0.714 (1.00) |
0.752 (1.00) |
0.431 (0.947) |
0.706 (1.00) |
0.445 (0.955) |
0.99 (1.00) |
0.384 (0.92) |
1 (1.00) |
0.0429 (0.423) |
CYP11A1 | 7 (1%) | 788 |
0.162 (0.712) |
0.114 (0.615) |
0.702 (1.00) |
1 (1.00) |
0.683 (1.00) |
0.408 (0.942) |
0.924 (1.00) |
0.385 (0.92) |
0.301 (0.864) |
KRT15 | 8 (1%) | 787 |
0.973 (1.00) |
0.25 (0.81) |
0.719 (1.00) |
0.48 (0.968) |
0.264 (0.831) |
0.905 (1.00) |
0.938 (1.00) |
0.424 (0.947) |
1 (1.00) |
CMA1 | 3 (0%) | 792 |
0.179 (0.715) |
0.916 (1.00) |
1 (1.00) |
1 (1.00) |
0.556 (1.00) |
0.558 (1.00) |
1 (1.00) |
1 (1.00) |
|
MAP3K12 | 6 (1%) | 789 |
0.0202 (0.285) |
0.868 (1.00) |
0.671 (1.00) |
1 (1.00) |
1 (1.00) |
0.313 (0.872) |
1 (1.00) |
1 (1.00) |
|
TREML2 | 7 (1%) | 788 |
0.934 (1.00) |
0.127 (0.65) |
0.25 (0.81) |
0.459 (0.955) |
1 (1.00) |
0.0842 (0.549) |
0.199 (0.74) |
0.339 (0.878) |
1 (1.00) |
PRCP | 5 (1%) | 790 |
0.0168 (0.256) |
0.0414 (0.422) |
0.351 (0.893) |
0.654 (1.00) |
1 (1.00) |
0.37 (0.902) |
0.572 (1.00) |
1 (1.00) |
0.184 (0.715) |
ESR2 | 6 (1%) | 789 |
0.582 (1.00) |
0.3 (0.864) |
0.43 (0.947) |
1 (1.00) |
1 (1.00) |
0.427 (0.947) |
0.906 (1.00) |
1 (1.00) |
1 (1.00) |
POM121 | 6 (1%) | 789 |
0.675 (1.00) |
0.233 (0.801) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.781 (1.00) |
0.448 (0.955) |
1 (1.00) |
1 (1.00) |
MACC1 | 8 (1%) | 787 |
0.642 (1.00) |
0.0837 (0.549) |
0.462 (0.955) |
0.0729 (0.541) |
1 (1.00) |
0.908 (1.00) |
0.411 (0.942) |
0.426 (0.947) |
1 (1.00) |
AOX1 | 8 (1%) | 787 |
0.748 (1.00) |
0.623 (1.00) |
0.462 (0.955) |
0.48 (0.968) |
1 (1.00) |
0.109 (0.609) |
0.412 (0.942) |
1 (1.00) |
1 (1.00) |
KRAS | 4 (1%) | 791 |
0.754 (1.00) |
0.709 (1.00) |
0.616 (1.00) |
1 (1.00) |
1 (1.00) |
0.338 (0.878) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
TYRP1 | 6 (1%) | 789 |
0.411 (0.942) |
0.163 (0.712) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.781 (1.00) |
0.0552 (0.489) |
1 (1.00) |
1 (1.00) |
EMG1 | 5 (1%) | 790 |
0.243 (0.801) |
0.686 (1.00) |
0.168 (0.712) |
0.167 (0.712) |
0.649 (1.00) |
0.0502 (0.47) |
0.243 (0.801) |
1 (1.00) |
1 (1.00) |
HEATR3 | 4 (1%) | 791 |
0.765 (1.00) |
0.134 (0.657) |
0.616 (1.00) |
1 (1.00) |
0.592 (1.00) |
1 (1.00) |
0.243 (0.801) |
1 (1.00) |
|
CDKN2A | 6 (1%) | 789 |
0.424 (0.947) |
0.834 (1.00) |
1 (1.00) |
0.409 (0.942) |
0.0791 (0.549) |
0.0331 (0.363) |
1 (1.00) |
0.0606 (0.504) |
0.0217 (0.301) |
SLC35A2 | 3 (0%) | 792 |
0.669 (1.00) |
0.439 (0.955) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.71 (1.00) |
1 (1.00) |
0.142 (0.671) |
|
MYH8 | 21 (3%) | 774 |
0.139 (0.664) |
0.491 (0.971) |
1 (1.00) |
0.179 (0.715) |
0.454 (0.955) |
0.448 (0.955) |
0.162 (0.712) |
0.511 (0.99) |
0.261 (0.829) |
DOCK5 | 20 (3%) | 775 |
0.936 (1.00) |
0.166 (0.712) |
0.164 (0.712) |
1 (1.00) |
0.018 (0.265) |
0.564 (1.00) |
0.212 (0.775) |
0.729 (1.00) |
0.223 (0.792) |
PAK1 | 3 (0%) | 792 |
0.15 (0.695) |
0.318 (0.873) |
1 (1.00) |
1 (1.00) |
0.556 (1.00) |
0.8 (1.00) |
1 (1.00) |
1 (1.00) |
|
KRT13 | 6 (1%) | 789 |
0.17 (0.715) |
0.921 (1.00) |
0.43 (0.947) |
0.241 (0.801) |
0.0791 (0.549) |
0.904 (1.00) |
0.335 (0.877) |
1 (1.00) |
1 (1.00) |
MYO5A | 5 (1%) | 790 |
0.258 (0.828) |
0.715 (1.00) |
0.662 (1.00) |
1 (1.00) |
0.332 (0.877) |
0.887 (1.00) |
1 (1.00) |
1 (1.00) |
|
MORN5 | 3 (0%) | 792 |
0.541 (1.00) |
0.0607 (0.504) |
1 (1.00) |
1 (1.00) |
0.23 (0.801) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
KRT3 | 4 (1%) | 791 |
0.824 (1.00) |
0.44 (0.955) |
0.303 (0.864) |
0.645 (1.00) |
1 (1.00) |
0.0524 (0.476) |
0.265 (0.833) |
1 (1.00) |
0.184 (0.715) |
LGALS13 | 4 (1%) | 791 |
0.537 (1.00) |
0.449 (0.955) |
1 (1.00) |
0.645 (1.00) |
1 (1.00) |
0.388 (0.92) |
0.316 (0.872) |
0.242 (0.801) |
0.184 (0.715) |
CD44 | 6 (1%) | 789 |
0.301 (0.864) |
0.139 (0.664) |
0.43 (0.947) |
0.241 (0.801) |
0.672 (1.00) |
0.906 (1.00) |
1 (1.00) |
1 (1.00) |
|
CD1D | 4 (1%) | 791 |
0.352 (0.893) |
0.0167 (0.256) |
0.0152 (0.251) |
1 (1.00) |
1 (1.00) |
0.681 (1.00) |
0.143 (0.676) |
1 (1.00) |
1 (1.00) |
CNOT1 | 8 (1%) | 787 |
0.0397 (0.413) |
0.0945 (0.584) |
0.272 (0.837) |
0.48 (0.968) |
1 (1.00) |
0.71 (1.00) |
0.334 (0.877) |
1 (1.00) |
1 (1.00) |
NAP1L2 | 6 (1%) | 789 |
0.523 (1.00) |
0.157 (0.705) |
1 (1.00) |
0.697 (1.00) |
1 (1.00) |
0.442 (0.955) |
0.434 (0.951) |
1 (1.00) |
1 (1.00) |
OR52M1 | 8 (1%) | 787 |
0.472 (0.962) |
0.792 (1.00) |
0.462 (0.955) |
1 (1.00) |
0.446 (0.955) |
0.886 (1.00) |
0.242 (0.801) |
0.185 (0.715) |
1 (1.00) |
OAS2 | 4 (1%) | 791 |
0.0311 (0.352) |
0.99 (1.00) |
0.128 (0.65) |
0.645 (1.00) |
0.316 (0.872) |
0.37 (0.902) |
0.468 (0.96) |
1 (1.00) |
1 (1.00) |
FMR1 | 5 (1%) | 790 |
0.0235 (0.304) |
0.0341 (0.372) |
0.168 (0.712) |
1 (1.00) |
1 (1.00) |
0.147 (0.687) |
0.08 (0.549) |
1 (1.00) |
1 (1.00) |
INF2 | 4 (1%) | 791 |
0.68 (1.00) |
0.999 (1.00) |
1 (1.00) |
0.313 (0.872) |
1 (1.00) |
0.588 (1.00) |
0.24 (0.801) |
1 (1.00) |
|
EPS8L1 | 4 (1%) | 791 |
0.126 (0.65) |
0.436 (0.954) |
0.616 (1.00) |
1 (1.00) |
1 (1.00) |
0.625 (1.00) |
1 (1.00) |
1 (1.00) |
|
CD209 | 10 (1%) | 785 |
0.174 (0.715) |
0.112 (0.615) |
0.335 (0.877) |
0.334 (0.877) |
0.728 (1.00) |
0.19 (0.723) |
0.873 (1.00) |
1 (1.00) |
0.369 (0.902) |
PRG4 | 10 (1%) | 785 |
0.326 (0.877) |
0.467 (0.96) |
0.507 (0.985) |
1 (1.00) |
1 (1.00) |
0.22 (0.79) |
0.158 (0.705) |
0.501 (0.978) |
0.401 (0.942) |
RFX4 | 6 (1%) | 789 |
0.367 (0.902) |
0.345 (0.89) |
1 (1.00) |
0.697 (1.00) |
0.672 (1.00) |
0.129 (0.65) |
0.763 (1.00) |
1 (1.00) |
1 (1.00) |
LUM | 7 (1%) | 788 |
0.889 (1.00) |
0.838 (1.00) |
0.103 (0.596) |
1 (1.00) |
0.672 (1.00) |
0.974 (1.00) |
0.0773 (0.549) |
0.383 (0.92) |
1 (1.00) |
MYT1 | 6 (1%) | 789 |
0.0577 (0.496) |
0.0648 (0.508) |
0.0957 (0.584) |
0.697 (1.00) |
0.185 (0.715) |
0.305 (0.865) |
0.0622 (0.504) |
1 (1.00) |
1 (1.00) |
KCNJ15 | 4 (1%) | 791 |
0.554 (1.00) |
0.585 (1.00) |
1 (1.00) |
0.645 (1.00) |
0.592 (1.00) |
0.922 (1.00) |
0.244 (0.801) |
1 (1.00) |
|
GFRA4 | 3 (0%) | 792 |
0.0789 (0.549) |
0.476 (0.967) |
0.285 (0.844) |
0.27 (0.835) |
0.556 (1.00) |
0.388 (0.92) |
0.882 (1.00) |
1 (1.00) |
1 (1.00) |
DLC1 | 9 (1%) | 786 |
0.456 (0.955) |
0.971 (1.00) |
1 (1.00) |
0.175 (0.715) |
0.0637 (0.504) |
0.659 (1.00) |
0.786 (1.00) |
1 (1.00) |
0.369 (0.902) |
TMPRSS6 | 9 (1%) | 786 |
0.918 (1.00) |
0.052 (0.476) |
0.0738 (0.541) |
0.502 (0.978) |
0.287 (0.844) |
1 (1.00) |
0.169 (0.712) |
1 (1.00) |
1 (1.00) |
DLX6 | 5 (1%) | 790 |
0.289 (0.847) |
0.58 (1.00) |
0.662 (1.00) |
0.408 (0.942) |
1 (1.00) |
0.512 (0.992) |
1 (1.00) |
1 (1.00) |
|
MAP3K1 | 9 (1%) | 786 |
0.84 (1.00) |
0.0402 (0.415) |
0.0738 (0.541) |
0.742 (1.00) |
0.287 (0.844) |
0.165 (0.712) |
0.275 (0.843) |
1 (1.00) |
1 (1.00) |
ROBO3 | 5 (1%) | 790 |
0.15 (0.693) |
0.185 (0.715) |
0.168 (0.712) |
0.654 (1.00) |
0.592 (1.00) |
0.856 (1.00) |
0.169 (0.712) |
1 (1.00) |
0.225 (0.792) |
SGOL2 | 9 (1%) | 786 |
0.268 (0.834) |
0.332 (0.877) |
1 (1.00) |
0.742 (1.00) |
0.471 (0.962) |
0.435 (0.953) |
0.973 (1.00) |
1 (1.00) |
0.301 (0.864) |
HTT | 5 (1%) | 790 |
0.0282 (0.341) |
0.412 (0.942) |
0.168 (0.712) |
0.654 (1.00) |
0.649 (1.00) |
0.103 (0.596) |
1 (1.00) |
1 (1.00) |
|
SON | 9 (1%) | 786 |
0.225 (0.792) |
0.887 (1.00) |
0.171 (0.715) |
1 (1.00) |
0.213 (0.776) |
0.502 (0.978) |
0.314 (0.872) |
1 (1.00) |
0.336 (0.877) |
PLXNA3 | 10 (1%) | 785 |
0.0473 (0.452) |
0.924 (1.00) |
0.109 (0.609) |
0.103 (0.596) |
0.287 (0.844) |
0.96 (1.00) |
0.429 (0.947) |
0.148 (0.687) |
1 (1.00) |
AMPD1 | 7 (1%) | 788 |
0.891 (1.00) |
0.424 (0.947) |
0.702 (1.00) |
0.459 (0.955) |
1 (1.00) |
0.834 (1.00) |
0.86 (1.00) |
1 (1.00) |
1 (1.00) |
TNFSF9 | 5 (1%) | 790 |
0.357 (0.897) |
0.934 (1.00) |
0.351 (0.893) |
0.408 (0.942) |
1 (1.00) |
0.451 (0.955) |
0.573 (1.00) |
1 (1.00) |
0.225 (0.792) |
TJAP1 | 3 (0%) | 792 |
0.267 (0.833) |
0.315 (0.872) |
0.285 (0.844) |
0.574 (1.00) |
1 (1.00) |
0.881 (1.00) |
1 (1.00) |
1 (1.00) |
|
KLKB1 | 7 (1%) | 788 |
0.218 (0.786) |
0.297 (0.863) |
1 (1.00) |
1 (1.00) |
0.445 (0.955) |
0.278 (0.844) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
CHGB | 8 (1%) | 787 |
0.168 (0.712) |
0.713 (1.00) |
0.462 (0.955) |
0.725 (1.00) |
0.063 (0.504) |
0.926 (1.00) |
0.745 (1.00) |
1 (1.00) |
1 (1.00) |
ALPK3 | 4 (1%) | 791 |
0.49 (0.971) |
0.357 (0.897) |
0.616 (1.00) |
1 (1.00) |
1 (1.00) |
0.624 (1.00) |
1 (1.00) |
0.184 (0.715) |
|
MYO1B | 10 (1%) | 785 |
0.278 (0.844) |
0.181 (0.715) |
0.179 (0.715) |
1 (1.00) |
0.287 (0.844) |
0.388 (0.92) |
0.155 (0.704) |
0.0841 (0.549) |
0.369 (0.902) |
SMOC1 | 4 (1%) | 791 |
0.461 (0.955) |
0.486 (0.971) |
1 (1.00) |
0.645 (1.00) |
1 (1.00) |
0.903 (1.00) |
0.585 (1.00) |
0.0826 (0.549) |
1 (1.00) |
ACSM1 | 7 (1%) | 788 |
0.412 (0.942) |
0.55 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.729 (1.00) |
0.704 (1.00) |
1 (1.00) |
1 (1.00) |
CIB1 | 5 (1%) | 790 |
0.493 (0.973) |
0.935 (1.00) |
0.662 (1.00) |
0.654 (1.00) |
1 (1.00) |
0.974 (1.00) |
0.889 (1.00) |
1 (1.00) |
1 (1.00) |
CDA | 3 (0%) | 792 |
0.718 (1.00) |
0.491 (0.971) |
0.285 (0.844) |
1 (1.00) |
1 (1.00) |
0.0815 (0.549) |
0.882 (1.00) |
1 (1.00) |
0.142 (0.671) |
TTC30B | 7 (1%) | 788 |
0.0971 (0.588) |
0.126 (0.65) |
0.431 (0.947) |
1 (1.00) |
1 (1.00) |
0.239 (0.801) |
0.534 (1.00) |
1 (1.00) |
1 (1.00) |
AGXT2L1 | 4 (1%) | 791 |
0.229 (0.801) |
0.89 (1.00) |
1 (1.00) |
1 (1.00) |
0.316 (0.872) |
0.588 (1.00) |
0.082 (0.549) |
1 (1.00) |
|
PRKCD | 3 (0%) | 792 |
0.308 (0.872) |
0.832 (1.00) |
0.0434 (0.425) |
1 (1.00) |
1 (1.00) |
0.247 (0.809) |
0.189 (0.72) |
1 (1.00) |
|
ST3GAL6 | 5 (1%) | 790 |
0.949 (1.00) |
0.354 (0.895) |
1 (1.00) |
0.654 (1.00) |
0.556 (1.00) |
0.176 (0.715) |
0.936 (1.00) |
1 (1.00) |
1 (1.00) |
SOX13 | 5 (1%) | 790 |
0.865 (1.00) |
0.939 (1.00) |
0.351 (0.893) |
0.408 (0.942) |
0.332 (0.877) |
0.442 (0.955) |
0.573 (1.00) |
1 (1.00) |
1 (1.00) |
NKX2-2 | 6 (1%) | 789 |
0.0282 (0.341) |
0.226 (0.792) |
0.0957 (0.584) |
0.241 (0.801) |
0.649 (1.00) |
0.925 (1.00) |
0.198 (0.739) |
1 (1.00) |
1 (1.00) |
SYBU | 3 (0%) | 792 |
0.639 (1.00) |
0.518 (0.999) |
0.285 (0.844) |
0.0718 (0.541) |
0.23 (0.801) |
0.724 (1.00) |
1 (1.00) |
1 (1.00) |
|
WDR90 | 9 (1%) | 786 |
0.462 (0.955) |
0.0979 (0.589) |
0.0738 (0.541) |
1 (1.00) |
0.446 (0.955) |
0.0347 (0.376) |
0.127 (0.65) |
1 (1.00) |
1 (1.00) |
TP63 | 10 (1%) | 785 |
0.592 (1.00) |
0.418 (0.947) |
0.179 (0.715) |
1 (1.00) |
0.446 (0.955) |
0.471 (0.962) |
0.546 (1.00) |
1 (1.00) |
0.336 (0.877) |
SLC2A3 | 5 (1%) | 790 |
0.65 (1.00) |
0.579 (1.00) |
1 (1.00) |
0.408 (0.942) |
0.316 (0.872) |
0.388 (0.92) |
0.936 (1.00) |
0.107 (0.609) |
1 (1.00) |
EGR1 | 5 (1%) | 790 |
0.822 (1.00) |
0.289 (0.847) |
0.351 (0.893) |
0.654 (1.00) |
0.649 (1.00) |
0.427 (0.947) |
0.47 (0.961) |
1 (1.00) |
1 (1.00) |
PRB3 | 3 (0%) | 792 |
0.16 (0.71) |
0.975 (1.00) |
1 (1.00) |
0.27 (0.835) |
1 (1.00) |
0.56 (1.00) |
1 (1.00) |
1 (1.00) |
|
FBN3 | 18 (2%) | 777 |
0.428 (0.947) |
0.0168 (0.256) |
0.0251 (0.322) |
0.0968 (0.588) |
0.604 (1.00) |
0.668 (1.00) |
0.0459 (0.445) |
0.106 (0.607) |
0.561 (1.00) |
FLNB | 10 (1%) | 785 |
0.212 (0.775) |
0.41 (0.942) |
1 (1.00) |
0.103 (0.596) |
1 (1.00) |
0.593 (1.00) |
0.58 (1.00) |
1 (1.00) |
1 (1.00) |
SLFN11 | 7 (1%) | 788 |
0.0833 (0.549) |
0.0521 (0.476) |
0.431 (0.947) |
0.706 (1.00) |
1 (1.00) |
0.965 (1.00) |
0.356 (0.897) |
1 (1.00) |
0.301 (0.864) |
SEZ6L2 | 7 (1%) | 788 |
0.445 (0.955) |
0.459 (0.955) |
0.25 (0.81) |
0.135 (0.657) |
0.185 (0.715) |
0.454 (0.955) |
0.754 (1.00) |
1 (1.00) |
1 (1.00) |
MAX | 6 (1%) | 789 |
0.742 (1.00) |
0.262 (0.83) |
1 (1.00) |
0.241 (0.801) |
1 (1.00) |
0.491 (0.971) |
0.952 (1.00) |
1 (1.00) |
1 (1.00) |
ZNF148 | 5 (1%) | 790 |
0.0392 (0.412) |
0.203 (0.755) |
0.662 (1.00) |
0.654 (1.00) |
0.178 (0.715) |
0.491 (0.971) |
0.108 (0.609) |
1 (1.00) |
|
PPL | 9 (1%) | 786 |
0.0175 (0.261) |
0.614 (1.00) |
1 (1.00) |
1 (1.00) |
0.728 (1.00) |
0.876 (1.00) |
0.628 (1.00) |
1 (1.00) |
0.336 (0.877) |
IGFN1 | 9 (1%) | 786 |
0.181 (0.715) |
0.0799 (0.549) |
0.0738 (0.541) |
0.742 (1.00) |
0.287 (0.844) |
0.572 (1.00) |
0.365 (0.902) |
1 (1.00) |
0.336 (0.877) |
GLYAT | 5 (1%) | 790 |
0.11 (0.609) |
0.882 (1.00) |
0.662 (1.00) |
0.408 (0.942) |
0.178 (0.715) |
0.693 (1.00) |
0.888 (1.00) |
1 (1.00) |
1 (1.00) |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
IDH1 MUTATED | 410 | 78 | 0.0 - 182.3 (25.2) |
IDH1 WILD-TYPE | 378 | 265 | 0.1 - 211.2 (12.6) |
P value = 3.8e-55 (Wilcoxon-test), Q value = 1.2e-52
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
IDH1 MUTATED | 413 | 41.0 (12.4) |
IDH1 WILD-TYPE | 381 | 58.4 (14.0) |
P value = 1.34e-97 (Fisher's exact test), Q value = 5.2e-95
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
IDH1 MUTATED | 14 | 400 |
IDH1 WILD-TYPE | 266 | 115 |
P value = 2.67e-08 (Fisher's exact test), Q value = 2e-06
nPatients | NO | YES |
---|---|---|
ALL | 232 | 513 |
IDH1 MUTATED | 157 | 235 |
IDH1 WILD-TYPE | 75 | 278 |
P value = 1.89e-16 (Wilcoxon-test), Q value = 2.6e-14
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
IDH1 MUTATED | 251 | 87.6 (12.1) |
IDH1 WILD-TYPE | 262 | 76.9 (17.3) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
IDH1 MUTATED | 136 | 1 | 109 | 155 | 0 | 13 |
IDH1 WILD-TYPE | 58 | 10 | 21 | 36 | 4 | 252 |
P value = 8.87e-10 (logrank test), Q value = 8e-08
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
TP53 MUTATED | 329 | 114 | 0.0 - 211.2 (22.3) |
TP53 WILD-TYPE | 459 | 229 | 0.1 - 182.3 (15.0) |
P value = 9.18e-19 (Wilcoxon-test), Q value = 1.4e-16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
TP53 MUTATED | 330 | 43.6 (15.2) |
TP53 WILD-TYPE | 464 | 53.5 (15.0) |
P value = 5.04e-08 (Fisher's exact test), Q value = 3.5e-06
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
TP53 MUTATED | 80 | 250 |
TP53 WILD-TYPE | 200 | 265 |
P value = 0.005 (Fisher's exact test), Q value = 0.11
nPatients | NO | YES |
---|---|---|
ALL | 232 | 513 |
TP53 MUTATED | 79 | 231 |
TP53 WILD-TYPE | 153 | 282 |
P value = 0.00118 (Wilcoxon-test), Q value = 0.034
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
TP53 MUTATED | 217 | 84.8 (13.9) |
TP53 WILD-TYPE | 296 | 80.1 (16.9) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
TP53 MUTATED | 131 | 2 | 74 | 45 | 0 | 78 |
TP53 WILD-TYPE | 63 | 9 | 56 | 146 | 4 | 187 |
P value = 5.77e-15 (logrank test), Q value = 7.4e-13
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
ATRX MUTATED | 212 | 55 | 0.0 - 211.2 (25.6) |
ATRX WILD-TYPE | 576 | 288 | 0.1 - 182.3 (15.2) |
P value = 6.85e-34 (Wilcoxon-test), Q value = 1.8e-31
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
ATRX MUTATED | 213 | 38.2 (12.3) |
ATRX WILD-TYPE | 581 | 53.4 (15.0) |
P value = 1.48e-26 (Fisher's exact test), Q value = 3.3e-24
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
ATRX MUTATED | 16 | 197 |
ATRX WILD-TYPE | 264 | 318 |
P value = 0.000108 (Wilcoxon-test), Q value = 0.0045
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
ATRX MUTATED | 133 | 86.4 (12.7) |
ATRX WILD-TYPE | 380 | 80.6 (16.6) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
ATRX MUTATED | 98 | 1 | 64 | 35 | 0 | 15 |
ATRX WILD-TYPE | 96 | 10 | 66 | 156 | 4 | 250 |
P value = 1.84e-12 (logrank test), Q value = 1.8e-10
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
CIC MUTATED | 108 | 13 | 0.1 - 211.2 (24.4) |
CIC WILD-TYPE | 680 | 330 | 0.0 - 172.8 (16.6) |
P value = 0.00112 (Wilcoxon-test), Q value = 0.033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
CIC MUTATED | 109 | 44.7 (13.6) |
CIC WILD-TYPE | 685 | 50.1 (16.0) |
P value = 2.84e-21 (Fisher's exact test), Q value = 4.9e-19
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
CIC MUTATED | 1 | 108 |
CIC WILD-TYPE | 279 | 407 |
P value = 2.15e-09 (Fisher's exact test), Q value = 1.7e-07
nPatients | NO | YES |
---|---|---|
ALL | 232 | 513 |
CIC MUTATED | 60 | 44 |
CIC WILD-TYPE | 172 | 469 |
P value = 0.000469 (Wilcoxon-test), Q value = 0.015
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
CIC MUTATED | 64 | 88.3 (11.2) |
CIC WILD-TYPE | 449 | 81.2 (16.2) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
CIC MUTATED | 3 | 0 | 23 | 82 | 0 | 1 |
CIC WILD-TYPE | 191 | 11 | 107 | 109 | 4 | 264 |
P value = 1.07e-05 (logrank test), Q value = 5e-04
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
NF1 MUTATED | 62 | 39 | 0.2 - 211.2 (12.6) |
NF1 WILD-TYPE | 726 | 304 | 0.0 - 182.3 (17.5) |
P value = 0.000558 (Wilcoxon-test), Q value = 0.018
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
NF1 MUTATED | 62 | 55.9 (15.2) |
NF1 WILD-TYPE | 732 | 48.8 (15.8) |
P value = 0.00293 (Wilcoxon-test), Q value = 0.074
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
PIK3R1 MUTATED | 54 | 55.5 (15.6) |
PIK3R1 WILD-TYPE | 740 | 48.9 (15.8) |
P value = 0.000307 (Fisher's exact test), Q value = 0.011
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
PIK3R1 MUTATED | 32 | 22 |
PIK3R1 WILD-TYPE | 248 | 493 |
P value = 0.00448 (Fisher's exact test), Q value = 0.1
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
PIK3R1 MUTATED | 8 | 1 | 3 | 11 | 0 | 31 |
PIK3R1 WILD-TYPE | 186 | 10 | 127 | 180 | 4 | 234 |
P value = 0.000471 (logrank test), Q value = 0.015
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
NOTCH1 MUTATED | 40 | 8 | 0.3 - 211.2 (27.9) |
NOTCH1 WILD-TYPE | 748 | 335 | 0.0 - 182.3 (16.9) |
P value = 1.1e-08 (Fisher's exact test), Q value = 8.4e-07
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
NOTCH1 MUTATED | 0 | 42 |
NOTCH1 WILD-TYPE | 280 | 473 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
NOTCH1 MUTATED | 6 | 0 | 7 | 29 | 0 | 0 |
NOTCH1 WILD-TYPE | 188 | 11 | 123 | 162 | 4 | 265 |
P value = 0.00169 (logrank test), Q value = 0.047
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
IDH2 MUTATED | 20 | 1 | 0.1 - 84.3 (30.4) |
IDH2 WILD-TYPE | 768 | 342 | 0.0 - 211.2 (17.2) |
P value = 0.000505 (Wilcoxon-test), Q value = 0.016
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
IDH2 MUTATED | 20 | 37.6 (9.7) |
IDH2 WILD-TYPE | 774 | 49.6 (15.8) |
P value = 0.000192 (Fisher's exact test), Q value = 0.0072
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
IDH2 MUTATED | 0 | 20 |
IDH2 WILD-TYPE | 280 | 495 |
P value = 3e-05 (Fisher's exact test), Q value = 0.0013
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
IDH2 MUTATED | 1 | 0 | 5 | 14 | 0 | 0 |
IDH2 WILD-TYPE | 193 | 11 | 125 | 177 | 4 | 265 |
P value = 0.0105 (logrank test), Q value = 0.19
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
RB1 MUTATED | 30 | 20 | 0.2 - 211.2 (14.2) |
RB1 WILD-TYPE | 758 | 323 | 0.0 - 182.3 (17.5) |
P value = 0.000292 (Wilcoxon-test), Q value = 0.01
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
RB1 MUTATED | 30 | 59.9 (14.2) |
RB1 WILD-TYPE | 764 | 48.9 (15.8) |
P value = 4.04e-07 (Fisher's exact test), Q value = 2.7e-05
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
RB1 MUTATED | 24 | 6 |
RB1 WILD-TYPE | 256 | 509 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
RB1 MUTATED | 5 | 2 | 0 | 1 | 0 | 22 |
RB1 WILD-TYPE | 189 | 9 | 130 | 190 | 4 | 243 |
P value = 0.000234 (logrank test), Q value = 0.0086
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
FUBP1 MUTATED | 46 | 6 | 0.1 - 211.2 (21.8) |
FUBP1 WILD-TYPE | 742 | 337 | 0.0 - 182.3 (17.2) |
P value = 1.03e-09 (Fisher's exact test), Q value = 8.8e-08
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
FUBP1 MUTATED | 0 | 47 |
FUBP1 WILD-TYPE | 280 | 468 |
P value = 0.00374 (Fisher's exact test), Q value = 0.091
nPatients | NO | YES |
---|---|---|
ALL | 232 | 513 |
FUBP1 MUTATED | 23 | 21 |
FUBP1 WILD-TYPE | 209 | 492 |
P value = 0.0102 (Wilcoxon-test), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
FUBP1 MUTATED | 29 | 89.0 (12.1) |
FUBP1 WILD-TYPE | 484 | 81.7 (16.0) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
FUBP1 MUTATED | 2 | 0 | 9 | 36 | 0 | 0 |
FUBP1 WILD-TYPE | 192 | 11 | 121 | 155 | 4 | 265 |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
PTEN MUTATED | 109 | 80 | 0.1 - 211.2 (12.6) |
PTEN WILD-TYPE | 679 | 263 | 0.0 - 182.3 (18.5) |
P value = 1.74e-14 (Wilcoxon-test), Q value = 2.1e-12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
PTEN MUTATED | 110 | 60.2 (12.9) |
PTEN WILD-TYPE | 684 | 47.6 (15.6) |
P value = 4.34e-23 (Fisher's exact test), Q value = 8.4e-21
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
PTEN MUTATED | 86 | 24 |
PTEN WILD-TYPE | 194 | 491 |
P value = 0.0017 (Wilcoxon-test), Q value = 0.047
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
PTEN MUTATED | 77 | 76.9 (18.3) |
PTEN WILD-TYPE | 436 | 83.1 (15.2) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
PTEN MUTATED | 17 | 1 | 4 | 3 | 2 | 83 |
PTEN WILD-TYPE | 177 | 10 | 126 | 188 | 2 | 182 |
P value = 0.00409 (logrank test), Q value = 0.098
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
ARID1A MUTATED | 22 | 4 | 6.7 - 211.2 (24.0) |
ARID1A WILD-TYPE | 766 | 339 | 0.0 - 182.3 (17.2) |
P value = 0.0108 (Fisher's exact test), Q value = 0.19
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
ARID1A MUTATED | 2 | 20 |
ARID1A WILD-TYPE | 278 | 495 |
P value = 0.00538 (Fisher's exact test), Q value = 0.11
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
ARID1A MUTATED | 4 | 1 | 7 | 9 | 0 | 1 |
ARID1A WILD-TYPE | 190 | 10 | 123 | 182 | 4 | 264 |
P value = 0.00485 (logrank test), Q value = 0.11
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
NIPBL MUTATED | 20 | 4 | 0.2 - 211.2 (22.5) |
NIPBL WILD-TYPE | 768 | 339 | 0.0 - 182.3 (17.2) |
P value = 0.0101 (Fisher's exact test), Q value = 0.18
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
NUDT11 MUTATED | 0 | 11 |
NUDT11 WILD-TYPE | 280 | 504 |
P value = 0.00257 (logrank test), Q value = 0.066
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
PLCG1 MUTATED | 11 | 9 | 6.7 - 39.0 (14.8) |
PLCG1 WILD-TYPE | 777 | 334 | 0.0 - 211.2 (17.5) |
P value = 0.0117 (Wilcoxon-test), Q value = 0.2
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
PLCG1 MUTATED | 11 | 60.5 (9.6) |
PLCG1 WILD-TYPE | 783 | 49.2 (15.8) |
P value = 0.00428 (logrank test), Q value = 0.099
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
PDGFRA MUTATED | 20 | 15 | 0.5 - 211.2 (9.7) |
PDGFRA WILD-TYPE | 768 | 328 | 0.0 - 182.3 (17.6) |
P value = 0.00213 (Fisher's exact test), Q value = 0.057
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
STAG2 MUTATED | 12 | 4 |
STAG2 WILD-TYPE | 268 | 511 |
P value = 0.000159 (logrank test), Q value = 0.0061
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
REN MUTATED | 7 | 6 | 1.0 - 34.5 (8.0) |
REN WILD-TYPE | 781 | 337 | 0.0 - 211.2 (17.5) |
P value = 0.00731 (Wilcoxon-test), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
HTRA2 MUTATED | 5 | 31.2 (9.7) |
HTRA2 WILD-TYPE | 789 | 49.5 (15.8) |
P value = 0.00312 (Fisher's exact test), Q value = 0.077
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
BRAF MUTATED | 5 | 2 | 0 | 0 | 0 | 4 |
BRAF WILD-TYPE | 189 | 9 | 130 | 191 | 4 | 261 |
P value = 0.0145 (Wilcoxon-test), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
MX2 MUTATED | 9 | 62.4 (11.9) |
MX2 WILD-TYPE | 785 | 49.2 (15.8) |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
EGFR MUTATED | 108 | 80 | 0.2 - 211.2 (13.6) |
EGFR WILD-TYPE | 680 | 263 | 0.0 - 182.3 (18.6) |
P value = 1.9e-14 (Wilcoxon-test), Q value = 2.1e-12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
EGFR MUTATED | 108 | 59.7 (10.9) |
EGFR WILD-TYPE | 686 | 47.7 (15.9) |
P value = 2.5e-13 (Fisher's exact test), Q value = 2.6e-11
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
EGFR MUTATED | 73 | 35 |
EGFR WILD-TYPE | 207 | 480 |
P value = 0.0017 (Fisher's exact test), Q value = 0.047
nPatients | NO | YES |
---|---|---|
ALL | 232 | 513 |
EGFR MUTATED | 18 | 83 |
EGFR WILD-TYPE | 214 | 430 |
P value = 2.1e-05 (Wilcoxon-test), Q value = 0.00095
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
EGFR MUTATED | 76 | 75.5 (16.8) |
EGFR WILD-TYPE | 437 | 83.3 (15.4) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00048
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
EGFR MUTATED | 20 | 1 | 7 | 8 | 0 | 72 |
EGFR WILD-TYPE | 174 | 10 | 123 | 183 | 4 | 193 |
P value = 0.00202 (Fisher's exact test), Q value = 0.055
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 35 | 671 |
WRN MUTATED | 3 | 3 |
WRN WILD-TYPE | 32 | 668 |
P value = 0.0107 (Fisher's exact test), Q value = 0.19
nPatients | FEMALE | MALE |
---|---|---|
ALL | 331 | 464 |
ZNF41 MUTATED | 7 | 1 |
ZNF41 WILD-TYPE | 324 | 463 |
P value = 0.00992 (Wilcoxon-test), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
ATF7IP2 MUTATED | 7 | 70.0 (10.0) |
ATF7IP2 WILD-TYPE | 506 | 82.3 (15.9) |
P value = 0.00113 (Fisher's exact test), Q value = 0.033
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
ZBTB20 MUTATED | 1 | 21 |
ZBTB20 WILD-TYPE | 279 | 494 |
P value = 0.00747 (Fisher's exact test), Q value = 0.15
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
ZBTB20 MUTATED | 5 | 0 | 4 | 12 | 0 | 1 |
ZBTB20 WILD-TYPE | 189 | 11 | 126 | 179 | 4 | 264 |
P value = 0.00507 (Fisher's exact test), Q value = 0.11
nPatients | FEMALE | MALE |
---|---|---|
ALL | 331 | 464 |
PDHA1 MUTATED | 6 | 0 |
PDHA1 WILD-TYPE | 325 | 464 |
P value = 0.00254 (Wilcoxon-test), Q value = 0.066
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
FAM123C MUTATED | 11 | 63.2 (13.2) |
FAM123C WILD-TYPE | 783 | 49.2 (15.8) |
P value = 0.00429 (logrank test), Q value = 0.099
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
DNMT3A MUTATED | 11 | 0 | 13.3 - 211.2 (20.2) |
DNMT3A WILD-TYPE | 777 | 343 | 0.0 - 182.3 (17.3) |
P value = 0.0101 (Fisher's exact test), Q value = 0.18
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
DNMT3A MUTATED | 0 | 11 |
DNMT3A WILD-TYPE | 280 | 504 |
P value = 0.00714 (logrank test), Q value = 0.14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
QKI MUTATED | 6 | 6 | 10.4 - 36.8 (15.8) |
QKI WILD-TYPE | 782 | 337 | 0.0 - 211.2 (17.4) |
P value = 0.000115 (logrank test), Q value = 0.0047
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
SMARCA4 MUTATED | 27 | 2 | 0.2 - 211.2 (28.1) |
SMARCA4 WILD-TYPE | 761 | 341 | 0.0 - 182.3 (17.0) |
P value = 0.000137 (Fisher's exact test), Q value = 0.0054
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
SMARCA4 MUTATED | 1 | 26 |
SMARCA4 WILD-TYPE | 279 | 489 |
P value = 0.00603 (Fisher's exact test), Q value = 0.13
nPatients | ASTROCYTOMA | GLIOBLASTOMA MULTIFORME (GBM) | OLIGOASTROCYTOMA | OLIGODENDROGLIOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|
ALL | 194 | 11 | 130 | 191 | 4 | 265 |
SMARCA4 MUTATED | 11 | 0 | 5 | 10 | 0 | 1 |
SMARCA4 WILD-TYPE | 183 | 11 | 125 | 181 | 4 | 264 |
P value = 0.000859 (Fisher's exact test), Q value = 0.026
nPatients | FEMALE | MALE |
---|---|---|
ALL | 331 | 464 |
GRHL3 MUTATED | 8 | 0 |
GRHL3 WILD-TYPE | 323 | 464 |
P value = 0.00962 (Wilcoxon-test), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 513 | 82.1 (15.9) |
TNFRSF9 MUTATED | 3 | 56.7 (5.8) |
TNFRSF9 WILD-TYPE | 510 | 82.3 (15.8) |
P value = 0.0107 (Fisher's exact test), Q value = 0.19
nPatients | FEMALE | MALE |
---|---|---|
ALL | 331 | 464 |
PASD1 MUTATED | 7 | 1 |
PASD1 WILD-TYPE | 324 | 463 |
P value = 6.81e-05 (logrank test), Q value = 0.0029
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
IL4R MUTATED | 10 | 8 | 1.4 - 24.2 (9.5) |
IL4R WILD-TYPE | 778 | 335 | 0.0 - 211.2 (17.5) |
P value = 0.000403 (Wilcoxon-test), Q value = 0.014
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
IL4R MUTATED | 10 | 67.5 (10.3) |
IL4R WILD-TYPE | 784 | 49.1 (15.8) |
P value = 0.0048 (Fisher's exact test), Q value = 0.11
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
IL4R MUTATED | 8 | 2 |
IL4R WILD-TYPE | 272 | 513 |
P value = 0.00414 (Fisher's exact test), Q value = 0.098
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
GABRA6 MUTATED | 11 | 4 |
GABRA6 WILD-TYPE | 269 | 511 |
P value = 0.00746 (logrank test), Q value = 0.15
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 788 | 343 | 0.0 - 211.2 (17.4) |
AK7 MUTATED | 8 | 6 | 2.5 - 42.7 (9.7) |
AK7 WILD-TYPE | 780 | 337 | 0.0 - 211.2 (17.5) |
P value = 0.00655 (Wilcoxon-test), Q value = 0.13
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 794 | 49.3 (15.8) |
DSP MUTATED | 20 | 58.5 (13.7) |
DSP WILD-TYPE | 774 | 49.1 (15.8) |
P value = 0.00906 (Fisher's exact test), Q value = 0.17
nPatients | BRAIN | CENTRAL NERVOUS SYSTEM |
---|---|---|
ALL | 280 | 515 |
PAN3 MUTATED | 6 | 1 |
PAN3 WILD-TYPE | 274 | 514 |
-
Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
-
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/GBMLGG-TP/22818077/transformed.cor.cli.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/GBMLGG-TP/22506567/GBMLGG-TP.merged_data.txt
-
Number of patients = 795
-
Number of significantly mutated genes = 171
-
Number of selected clinical features = 9
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.