E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.0 0.053 -9999.0 0.0 -0.31 13.0 13.0 KLHL20 0.031 0.079 0.173 58.0 -0.193 13.0 71.0 CYFIP2 0.019 0.017 -9999.0 0.0 0.0 223.0 223.0 Rac1/GDP -0.011 0.047 0.22 1.0 -0.188 3.0 4.0 ENAH -0.002 0.056 -9999.0 0.0 -0.308 15.0 15.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 0.0 12.0 12.0 CTNNB1 0.032 0.006 -9999.0 0.0 0.0 15.0 15.0 CDC42/GTP -0.035 0.051 0.106 46.0 -0.151 4.0 50.0 ABI1/Sra1/Nap1 -0.012 0.024 -9999.0 0.0 -0.124 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.074 0.035 -9999.0 0.0 -0.053 25.0 25.0 RAPGEF1 -0.002 0.073 0.27 4.0 -0.294 9.0 13.0 CTNND1 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 regulation of calcium-dependent cell-cell adhesion 0.016 0.057 -9999.0 0.0 -0.308 14.0 14.0 CRK 0.001 0.072 0.161 54.0 -0.303 11.0 65.0 E-cadherin/gamma catenin/alpha catenin 0.059 0.027 -9999.0 0.0 -0.047 18.0 18.0 alphaE/beta7 Integrin 0.047 0.012 -9999.0 0.0 -0.016 2.0 2.0 IQGAP1 0.025 0.015 -9999.0 0.0 0.0 131.0 131.0 NCKAP1 0.033 0.003 -9999.0 0.0 0.0 3.0 3.0 Rap1/GTP/I-afadin 0.035 0.022 -9999.0 0.0 -0.029 48.0 48.0 DLG1 -0.002 0.056 -9999.0 0.0 -0.308 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.039 0.025 -9999.0 0.0 -0.108 11.0 11.0 MLLT4 0.03 0.009 -9999.0 0.0 0.0 45.0 45.0 ARF6/GTP/NME1/Tiam1 0.036 0.02 -9999.0 0.0 -0.029 33.0 33.0 PI3K -0.048 0.032 -9999.0 0.0 -0.135 11.0 11.0 ARF6 0.031 0.008 -9999.0 0.0 0.0 31.0 31.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.046 0.014 -9999.0 0.0 -0.016 13.0 13.0 TIAM1 0.031 0.009 -9999.0 0.0 0.0 37.0 37.0 E-cadherin(dimer)/Ca2+ 0.069 0.03 -9999.0 0.0 -0.049 24.0 24.0 AKT1 -0.022 0.046 0.145 12.0 -9999.0 0.0 12.0 PIK3R1 0.03 0.01 -9999.0 0.0 0.0 47.0 47.0 CDH1 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 RhoA/GDP -0.009 0.072 0.255 4.0 -0.201 5.0 9.0 actin cytoskeleton organization 0.027 0.063 0.142 59.0 -0.142 13.0 72.0 CDC42/GDP -0.01 0.07 0.242 4.0 -0.199 5.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.027 -9999.0 0.0 -0.118 21.0 21.0 ITGB7 0.032 0.006 -9999.0 0.0 0.0 17.0 17.0 RAC1 0.02 0.016 -9999.0 0.0 0.0 204.0 204.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.075 0.033 -9999.0 0.0 -0.053 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.053 0.023 -9999.0 0.0 -0.038 21.0 21.0 mol:GDP -0.006 0.072 0.255 5.0 -0.207 8.0 13.0 CDC42/GTP/IQGAP1 0.029 0.025 -9999.0 0.0 -0.013 116.0 116.0 JUP 0.032 0.007 -9999.0 0.0 0.0 24.0 24.0 p120 catenin/RhoA/GDP -0.011 0.078 0.254 4.0 -0.199 8.0 12.0 RAC1/GTP/IQGAP1 0.017 0.024 -9999.0 0.0 -0.013 84.0 84.0 PIP5K1C/AP1M1 0.022 0.008 -9999.0 0.0 0.0 54.0 54.0 RHOA 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 CDC42 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 CTNNA1 0.033 0.005 -9999.0 0.0 0.0 10.0 10.0 positive regulation of S phase of mitotic cell cycle 0.016 0.043 0.104 50.0 -0.094 12.0 62.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.002 0.056 -9999.0 0.0 -0.309 15.0 15.0 regulation of cell-cell adhesion -0.04 0.024 -9999.0 0.0 -0.116 12.0 12.0 WASF2 -0.007 0.013 -9999.0 0.0 -0.068 15.0 15.0 Rap1/GTP -0.027 0.062 0.137 55.0 -0.181 2.0 57.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.085 0.04 -9999.0 0.0 -0.065 7.0 7.0 CCND1 0.018 0.05 0.119 50.0 -0.114 12.0 62.0 VAV2 0.011 0.128 -9999.0 0.0 -0.547 18.0 18.0 RAP1/GDP -0.016 0.064 0.149 45.0 -0.194 2.0 47.0 adherens junction assembly -0.001 0.055 -9999.0 0.0 -0.301 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.015 -9999.0 0.0 0.0 138.0 138.0 PIP5K1C 0.03 0.01 -9999.0 0.0 0.0 54.0 54.0 regulation of heterotypic cell-cell adhesion 0.052 0.036 0.19 4.0 -9999.0 0.0 4.0 E-cadherin/beta catenin -0.002 0.024 -9999.0 0.0 -0.162 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.001 0.051 -9999.0 0.0 -0.31 12.0 12.0 PIK3CA 0.031 0.009 -9999.0 0.0 0.0 41.0 41.0 Rac1/GTP -0.008 0.055 -9999.0 0.0 -0.287 14.0 14.0 E-cadherin/beta catenin/alpha catenin 0.06 0.027 -9999.0 0.0 -0.047 21.0 21.0 ITGAE 0.032 0.005 -9999.0 0.0 0.0 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.016 0.058 -9999.0 0.0 -0.314 14.0 14.0