This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Testing the association between mutation status of 62 genes and 14 clinical features across 511 patients, 17 significant findings detected with Q value < 0.25.
-
NSD1 mutation correlated to 'NUMBER_OF_LYMPH_NODES'.
-
CASP8 mutation correlated to 'YEARS_TO_BIRTH' and 'GENDER'.
-
FAT1 mutation correlated to 'YEARS_TO_BIRTH' and 'GENDER'.
-
JUB mutation correlated to 'YEARS_TO_BIRTH' and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
-
NFE2L2 mutation correlated to 'YEARS_TO_BIRTH'.
-
RAC1 mutation correlated to 'YEARS_TO_BIRTH' and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
-
RB1 mutation correlated to 'GENDER'.
-
NAP1L2 mutation correlated to 'ETHNICITY'.
-
MLL4 mutation correlated to 'YEARS_TO_BIRTH'.
-
THSD7A mutation correlated to 'NUMBER_PACK_YEARS_SMOKED'.
-
CTCF mutation correlated to 'YEARS_TO_BIRTH'.
-
NOTCH2 mutation correlated to 'GENDER'.
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AK5 mutation correlated to 'Time to Death'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
PATHOLOGIC STAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
RADIATION THERAPY |
HISTOLOGICAL TYPE |
NUMBER PACK YEARS SMOKED |
YEAR OF TOBACCO SMOKING ONSET |
NUMBER OF LYMPH NODES |
RACE | ETHNICITY | ||
nMutated (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Wilcoxon-test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | |
CASP8 | 54 (11%) | 457 |
0.0632 (0.773) |
7.62e-09 (6.61e-06) |
0.725 (1.00) |
0.463 (1.00) |
0.0824 (0.836) |
1 (1.00) |
0.000523 (0.113) |
0.0854 (0.842) |
0.65 (1.00) |
0.0629 (0.773) |
0.0199 (0.479) |
0.0232 (0.503) |
0.435 (1.00) |
0.34 (1.00) |
FAT1 | 112 (22%) | 399 |
0.389 (1.00) |
2.31e-07 (1e-04) |
0.354 (1.00) |
0.0228 (0.503) |
0.207 (0.933) |
0.229 (0.933) |
0.00365 (0.227) |
0.719 (1.00) |
0.766 (1.00) |
0.0799 (0.83) |
0.00871 (0.293) |
0.36 (1.00) |
0.587 (1.00) |
0.45 (1.00) |
JUB | 34 (7%) | 477 |
0.0245 (0.518) |
0.00254 (0.184) |
0.651 (1.00) |
0.606 (1.00) |
0.224 (0.933) |
1 (1.00) |
0.695 (1.00) |
0.847 (1.00) |
1 (1.00) |
0.214 (0.933) |
0.0029 (0.194) |
0.47 (1.00) |
0.275 (0.983) |
0.674 (1.00) |
RAC1 | 15 (3%) | 496 |
0.485 (1.00) |
0.00117 (0.113) |
0.216 (0.933) |
0.18 (0.907) |
0.359 (1.00) |
1 (1.00) |
0.00653 (0.287) |
1 (1.00) |
1 (1.00) |
0.708 (1.00) |
0.00434 (0.235) |
0.179 (0.907) |
0.208 (0.933) |
1 (1.00) |
NSD1 | 62 (12%) | 449 |
0.0379 (0.6) |
0.0912 (0.851) |
0.162 (0.907) |
0.404 (1.00) |
0.0335 (0.6) |
0.141 (0.907) |
0.171 (0.907) |
1 (1.00) |
0.427 (1.00) |
0.115 (0.87) |
0.401 (1.00) |
0.000124 (0.0358) |
0.765 (1.00) |
0.206 (0.933) |
NFE2L2 | 27 (5%) | 484 |
0.283 (0.986) |
0.00183 (0.158) |
0.726 (1.00) |
0.73 (1.00) |
0.667 (1.00) |
1 (1.00) |
0.118 (0.87) |
0.09 (0.851) |
1 (1.00) |
0.497 (1.00) |
0.377 (1.00) |
0.51 (1.00) |
0.417 (1.00) |
0.346 (1.00) |
RB1 | 17 (3%) | 494 |
0.072 (0.791) |
0.353 (1.00) |
0.154 (0.907) |
0.226 (0.933) |
0.58 (1.00) |
1 (1.00) |
0.00104 (0.113) |
0.796 (1.00) |
1 (1.00) |
0.686 (1.00) |
0.281 (0.985) |
0.201 (0.933) |
0.245 (0.961) |
0.586 (1.00) |
NAP1L2 | 7 (1%) | 504 |
0.932 (1.00) |
0.259 (0.961) |
0.78 (1.00) |
1 (1.00) |
0.773 (1.00) |
1 (1.00) |
0.394 (1.00) |
1 (1.00) |
0.142 (0.907) |
0.249 (0.961) |
0.423 (1.00) |
0.887 (1.00) |
1 (1.00) |
0.00234 (0.184) |
MLL4 | 19 (4%) | 492 |
0.312 (1.00) |
0.000866 (0.113) |
0.194 (0.926) |
0.923 (1.00) |
0.0864 (0.843) |
1 (1.00) |
0.184 (0.907) |
0.451 (1.00) |
1 (1.00) |
0.642 (1.00) |
0.0502 (0.722) |
0.144 (0.907) |
0.441 (1.00) |
0.614 (1.00) |
THSD7A | 32 (6%) | 479 |
0.676 (1.00) |
0.704 (1.00) |
0.951 (1.00) |
0.215 (0.933) |
0.902 (1.00) |
1 (1.00) |
0.41 (1.00) |
0.31 (1.00) |
0.511 (1.00) |
0.00466 (0.238) |
0.521 (1.00) |
0.069 (0.791) |
0.55 (1.00) |
0.674 (1.00) |
CTCF | 15 (3%) | 496 |
0.0355 (0.6) |
0.00107 (0.113) |
0.161 (0.907) |
1 (1.00) |
0.412 (1.00) |
1 (1.00) |
0.0338 (0.6) |
0.774 (1.00) |
1 (1.00) |
0.981 (1.00) |
0.038 (0.6) |
0.326 (1.00) |
0.343 (1.00) |
1 (1.00) |
NOTCH2 | 21 (4%) | 490 |
0.545 (1.00) |
0.147 (0.907) |
0.333 (1.00) |
0.78 (1.00) |
0.692 (1.00) |
1 (1.00) |
0.00398 (0.23) |
0.609 (1.00) |
1 (1.00) |
0.129 (0.876) |
0.158 (0.907) |
0.514 (1.00) |
0.831 (1.00) |
0.618 (1.00) |
AK5 | 13 (3%) | 498 |
0.000923 (0.113) |
0.326 (1.00) |
0.768 (1.00) |
0.383 (1.00) |
0.657 (1.00) |
1 (1.00) |
0.351 (1.00) |
1 (1.00) |
1 (1.00) |
0.816 (1.00) |
0.543 (1.00) |
0.456 (1.00) |
0.5 (1.00) |
0.0927 (0.851) |
TP53 | 364 (71%) | 147 |
0.00696 (0.287) |
0.53 (1.00) |
0.502 (1.00) |
0.0187 (0.476) |
0.627 (1.00) |
1 (1.00) |
0.913 (1.00) |
0.328 (1.00) |
0.00728 (0.287) |
0.114 (0.87) |
0.723 (1.00) |
0.603 (1.00) |
0.328 (1.00) |
0.0685 (0.791) |
CDKN2A | 112 (22%) | 399 |
0.996 (1.00) |
0.112 (0.87) |
0.168 (0.907) |
0.812 (1.00) |
0.398 (1.00) |
1 (1.00) |
0.904 (1.00) |
0.548 (1.00) |
0.254 (0.961) |
0.648 (1.00) |
0.402 (1.00) |
0.224 (0.933) |
0.495 (1.00) |
0.474 (1.00) |
MLL2 | 81 (16%) | 430 |
0.125 (0.876) |
0.289 (0.986) |
0.355 (1.00) |
0.215 (0.933) |
0.769 (1.00) |
1 (1.00) |
1 (1.00) |
0.789 (1.00) |
0.477 (1.00) |
0.449 (1.00) |
0.866 (1.00) |
0.945 (1.00) |
0.113 (0.87) |
0.401 (1.00) |
TGFBR2 | 24 (5%) | 487 |
0.862 (1.00) |
0.109 (0.87) |
0.949 (1.00) |
0.705 (1.00) |
0.704 (1.00) |
1 (1.00) |
1 (1.00) |
0.484 (1.00) |
1 (1.00) |
0.386 (1.00) |
0.23 (0.933) |
0.49 (1.00) |
0.846 (1.00) |
1 (1.00) |
HLA-B | 24 (5%) | 487 |
0.963 (1.00) |
0.197 (0.933) |
0.751 (1.00) |
0.371 (1.00) |
0.0302 (0.6) |
1 (1.00) |
0.104 (0.87) |
0.167 (0.907) |
0.415 (1.00) |
0.225 (0.933) |
0.129 (0.876) |
0.287 (0.986) |
0.604 (1.00) |
0.614 (1.00) |
FBXW7 | 33 (6%) | 478 |
0.318 (1.00) |
0.00668 (0.287) |
0.748 (1.00) |
0.42 (1.00) |
0.324 (1.00) |
1 (1.00) |
0.107 (0.87) |
0.326 (1.00) |
1 (1.00) |
0.323 (1.00) |
0.967 (1.00) |
0.17 (0.907) |
1 (1.00) |
0.66 (1.00) |
NOTCH1 | 90 (18%) | 421 |
0.1 (0.87) |
0.00878 (0.293) |
0.354 (1.00) |
0.296 (0.991) |
0.674 (1.00) |
0.172 (0.907) |
0.0894 (0.851) |
0.0204 (0.479) |
1 (1.00) |
0.0551 (0.736) |
0.185 (0.907) |
0.36 (1.00) |
0.933 (1.00) |
0.188 (0.909) |
ZNF750 | 21 (4%) | 490 |
0.974 (1.00) |
0.135 (0.893) |
0.21 (0.933) |
0.559 (1.00) |
0.227 (0.933) |
1 (1.00) |
0.217 (0.933) |
0.473 (1.00) |
0.373 (1.00) |
0.765 (1.00) |
0.541 (1.00) |
0.0348 (0.6) |
0.178 (0.907) |
0.618 (1.00) |
HLA-A | 22 (4%) | 489 |
0.755 (1.00) |
0.0758 (0.812) |
0.884 (1.00) |
0.0737 (0.8) |
0.416 (1.00) |
1 (1.00) |
1 (1.00) |
0.13 (0.876) |
1 (1.00) |
0.439 (1.00) |
0.0117 (0.377) |
0.559 (1.00) |
0.67 (1.00) |
0.614 (1.00) |
EPHA2 | 24 (5%) | 487 |
0.293 (0.991) |
0.0846 (0.842) |
0.874 (1.00) |
0.653 (1.00) |
0.518 (1.00) |
1 (1.00) |
0.484 (1.00) |
0.167 (0.907) |
1 (1.00) |
0.0478 (0.703) |
0.184 (0.907) |
0.933 (1.00) |
0.587 (1.00) |
1 (1.00) |
HRAS | 31 (6%) | 480 |
0.247 (0.961) |
0.397 (1.00) |
0.409 (1.00) |
0.65 (1.00) |
0.141 (0.907) |
1 (1.00) |
0.0614 (0.773) |
0.22 (0.933) |
0.5 (1.00) |
0.733 (1.00) |
0.464 (1.00) |
0.0801 (0.83) |
0.388 (1.00) |
0.395 (1.00) |
EP300 | 38 (7%) | 473 |
0.247 (0.961) |
0.541 (1.00) |
0.988 (1.00) |
0.504 (1.00) |
0.388 (1.00) |
1 (1.00) |
0.569 (1.00) |
0.705 (1.00) |
0.579 (1.00) |
0.115 (0.87) |
0.911 (1.00) |
0.695 (1.00) |
0.824 (1.00) |
1 (1.00) |
OR6C65 | 16 (3%) | 495 |
0.243 (0.961) |
0.985 (1.00) |
0.528 (1.00) |
0.937 (1.00) |
0.874 (1.00) |
1 (1.00) |
0.257 (0.961) |
0.278 (0.985) |
1 (1.00) |
0.58 (1.00) |
0.443 (1.00) |
0.917 (1.00) |
0.573 (1.00) |
1 (1.00) |
PIK3CA | 94 (18%) | 417 |
0.828 (1.00) |
0.879 (1.00) |
0.29 (0.986) |
0.324 (1.00) |
0.104 (0.87) |
1 (1.00) |
0.0545 (0.736) |
0.899 (1.00) |
0.753 (1.00) |
0.803 (1.00) |
0.797 (1.00) |
0.508 (1.00) |
0.0909 (0.851) |
0.595 (1.00) |
PTEN | 14 (3%) | 497 |
0.205 (0.933) |
0.32 (1.00) |
0.935 (1.00) |
0.29 (0.986) |
0.491 (1.00) |
1 (1.00) |
1 (1.00) |
0.779 (1.00) |
1 (1.00) |
0.426 (1.00) |
0.15 (0.907) |
0.496 (1.00) |
0.563 (1.00) |
1 (1.00) |
RASA1 | 18 (4%) | 493 |
0.507 (1.00) |
0.347 (1.00) |
0.118 (0.87) |
0.376 (1.00) |
0.733 (1.00) |
0.0365 (0.6) |
0.423 (1.00) |
0.306 (1.00) |
1 (1.00) |
0.162 (0.907) |
0.853 (1.00) |
0.361 (1.00) |
0.62 (1.00) |
1 (1.00) |
MAPK1 | 9 (2%) | 502 |
0.161 (0.907) |
0.95 (1.00) |
0.869 (1.00) |
0.412 (1.00) |
0.65 (1.00) |
1 (1.00) |
0.708 (1.00) |
0.726 (1.00) |
1 (1.00) |
0.46 (1.00) |
0.865 (1.00) |
0.239 (0.961) |
1 (1.00) |
|
NUDT11 | 9 (2%) | 502 |
0.254 (0.961) |
0.351 (1.00) |
0.58 (1.00) |
0.758 (1.00) |
0.649 (1.00) |
1 (1.00) |
0.122 (0.876) |
0.0961 (0.851) |
1 (1.00) |
0.584 (1.00) |
0.295 (0.991) |
0.504 (1.00) |
1 (1.00) |
0.389 (1.00) |
KDM6A | 17 (3%) | 494 |
0.26 (0.961) |
0.0534 (0.736) |
0.399 (1.00) |
0.258 (0.961) |
0.804 (1.00) |
1 (1.00) |
1 (1.00) |
0.784 (1.00) |
1 (1.00) |
0.146 (0.907) |
0.179 (0.907) |
0.876 (1.00) |
0.491 (1.00) |
1 (1.00) |
KEAP1 | 22 (4%) | 489 |
0.765 (1.00) |
0.096 (0.851) |
0.151 (0.907) |
0.00782 (0.293) |
0.37 (1.00) |
1 (1.00) |
0.144 (0.907) |
0.0159 (0.454) |
0.105 (0.87) |
0.0943 (0.851) |
0.302 (1.00) |
0.871 (1.00) |
0.69 (1.00) |
0.614 (1.00) |
KRT17 | 6 (1%) | 505 |
0.21 (0.933) |
0.643 (1.00) |
0.259 (0.961) |
0.186 (0.907) |
0.0507 (0.722) |
0.351 (1.00) |
0.614 (1.00) |
1 (1.00) |
0.901 (1.00) |
0.945 (1.00) |
0.122 (0.876) |
0.536 (1.00) |
1 (1.00) |
|
RHOA | 10 (2%) | 501 |
0.512 (1.00) |
0.39 (1.00) |
1 (1.00) |
0.386 (1.00) |
0.0367 (0.6) |
1 (1.00) |
0.47 (1.00) |
0.505 (1.00) |
0.199 (0.933) |
0.696 (1.00) |
0.572 (1.00) |
0.343 (1.00) |
0.691 (1.00) |
1 (1.00) |
PTPN14 | 16 (3%) | 495 |
0.154 (0.907) |
0.828 (1.00) |
0.0409 (0.623) |
0.852 (1.00) |
0.249 (0.961) |
0.0365 (0.6) |
0.775 (1.00) |
0.591 (1.00) |
1 (1.00) |
0.738 (1.00) |
0.592 (1.00) |
0.412 (1.00) |
0.0619 (0.773) |
0.586 (1.00) |
KRTAP5-5 | 4 (1%) | 507 |
0.73 (1.00) |
0.425 (1.00) |
0.0649 (0.783) |
0.192 (0.919) |
1 (1.00) |
1 (1.00) |
0.296 (0.991) |
1 (1.00) |
1 (1.00) |
0.584 (1.00) |
0.267 (0.97) |
0.804 (1.00) |
1 (1.00) |
1 (1.00) |
ZNF623 | 12 (2%) | 499 |
0.311 (1.00) |
0.643 (1.00) |
1 (1.00) |
0.787 (1.00) |
0.794 (1.00) |
1 (1.00) |
0.742 (1.00) |
0.754 (1.00) |
1 (1.00) |
0.803 (1.00) |
0.578 (1.00) |
0.243 (0.961) |
0.499 (1.00) |
1 (1.00) |
TIGD4 | 7 (1%) | 504 |
0.32 (1.00) |
0.175 (0.907) |
0.253 (0.961) |
0.776 (1.00) |
0.171 (0.907) |
1 (1.00) |
0.68 (1.00) |
0.662 (1.00) |
1 (1.00) |
0.501 (1.00) |
0.403 (1.00) |
0.167 (0.907) |
0.589 (1.00) |
1 (1.00) |
CUL3 | 16 (3%) | 495 |
0.924 (1.00) |
0.377 (1.00) |
0.24 (0.961) |
0.16 (0.907) |
0.948 (1.00) |
1 (1.00) |
0.257 (0.961) |
0.784 (1.00) |
1 (1.00) |
0.776 (1.00) |
0.336 (1.00) |
0.285 (0.986) |
0.0366 (0.6) |
1 (1.00) |
CREBBP | 34 (7%) | 477 |
0.507 (1.00) |
0.0168 (0.454) |
0.753 (1.00) |
0.73 (1.00) |
0.887 (1.00) |
1 (1.00) |
0.548 (1.00) |
1 (1.00) |
0.537 (1.00) |
0.715 (1.00) |
0.0351 (0.6) |
0.689 (1.00) |
0.104 (0.87) |
1 (1.00) |
VEZF1 | 8 (2%) | 503 |
0.53 (1.00) |
0.944 (1.00) |
0.0129 (0.386) |
0.0167 (0.454) |
0.066 (0.784) |
1 (1.00) |
1 (1.00) |
0.0535 (0.736) |
0.161 (0.907) |
0.707 (1.00) |
0.558 (1.00) |
0.189 (0.912) |
1 (1.00) |
0.354 (1.00) |
IRS4 | 17 (3%) | 494 |
0.733 (1.00) |
0.931 (1.00) |
0.698 (1.00) |
0.786 (1.00) |
0.389 (1.00) |
1 (1.00) |
0.263 (0.961) |
0.556 (1.00) |
1 (1.00) |
0.802 (1.00) |
0.911 (1.00) |
0.144 (0.907) |
0.758 (1.00) |
0.184 (0.907) |
HUWE1 | 46 (9%) | 465 |
0.417 (1.00) |
0.419 (1.00) |
0.842 (1.00) |
0.619 (1.00) |
0.492 (1.00) |
1 (1.00) |
0.0352 (0.6) |
0.863 (1.00) |
1 (1.00) |
0.261 (0.961) |
0.581 (1.00) |
0.52 (1.00) |
0.0396 (0.614) |
0.275 (0.983) |
C3ORF59 | 10 (2%) | 501 |
0.947 (1.00) |
0.391 (1.00) |
0.954 (1.00) |
0.757 (1.00) |
0.359 (1.00) |
1 (1.00) |
0.734 (1.00) |
0.271 (0.981) |
1 (1.00) |
0.65 (1.00) |
0.727 (1.00) |
0.539 (1.00) |
1 (1.00) |
1 (1.00) |
DYSF | 20 (4%) | 491 |
0.733 (1.00) |
0.0614 (0.773) |
0.96 (1.00) |
0.658 (1.00) |
0.0942 (0.851) |
1 (1.00) |
0.798 (1.00) |
1 (1.00) |
1 (1.00) |
0.0265 (0.548) |
0.107 (0.87) |
0.0718 (0.791) |
0.823 (1.00) |
0.614 (1.00) |
ZNF233 | 9 (2%) | 502 |
0.314 (1.00) |
0.281 (0.985) |
0.392 (1.00) |
0.468 (1.00) |
0.228 (0.933) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.0702 (0.791) |
0.116 (0.87) |
0.00841 (0.293) |
0.684 (1.00) |
1 (1.00) |
|
KIAA1267 | 11 (2%) | 500 |
0.458 (1.00) |
0.263 (0.961) |
0.474 (1.00) |
0.22 (0.933) |
0.889 (1.00) |
1 (1.00) |
0.498 (1.00) |
0.754 (1.00) |
1 (1.00) |
0.884 (1.00) |
0.469 (1.00) |
0.489 (1.00) |
0.696 (1.00) |
0.11 (0.87) |
ASXL1 | 16 (3%) | 495 |
0.288 (0.986) |
0.837 (1.00) |
0.517 (1.00) |
0.175 (0.907) |
0.124 (0.876) |
1 (1.00) |
0.775 (1.00) |
0.00557 (0.269) |
1 (1.00) |
0.949 (1.00) |
0.782 (1.00) |
0.836 (1.00) |
0.772 (1.00) |
1 (1.00) |
SMAD4 | 13 (3%) | 498 |
0.602 (1.00) |
0.304 (1.00) |
0.771 (1.00) |
1 (1.00) |
0.618 (1.00) |
1 (1.00) |
1 (1.00) |
0.526 (1.00) |
1 (1.00) |
0.402 (1.00) |
0.171 (0.907) |
0.902 (1.00) |
1 (1.00) |
1 (1.00) |
GAGE2A | 4 (1%) | 507 |
0.904 (1.00) |
0.307 (1.00) |
0.642 (1.00) |
0.797 (1.00) |
1 (1.00) |
1 (1.00) |
0.578 (1.00) |
0.28 (0.985) |
1 (1.00) |
0.755 (1.00) |
0.397 (1.00) |
1 (1.00) |
||
EMG1 | 3 (1%) | 508 |
0.663 (1.00) |
0.812 (1.00) |
0.817 (1.00) |
0.85 (1.00) |
0.118 (0.87) |
1 (1.00) |
0.179 (0.907) |
0.28 (0.985) |
1 (1.00) |
0.578 (1.00) |
1 (1.00) |
1 (1.00) |
||
PIK3R1 | 8 (2%) | 503 |
0.129 (0.876) |
0.936 (1.00) |
0.521 (1.00) |
0.797 (1.00) |
0.156 (0.907) |
1 (1.00) |
0.689 (1.00) |
0.719 (1.00) |
1 (1.00) |
0.914 (1.00) |
0.962 (1.00) |
0.167 (0.907) |
1 (1.00) |
1 (1.00) |
KRTAP5-7 | 5 (1%) | 506 |
0.169 (0.907) |
0.495 (1.00) |
0.405 (1.00) |
0.782 (1.00) |
0.689 (1.00) |
1 (1.00) |
0.125 (0.876) |
0.348 (1.00) |
1 (1.00) |
0.959 (1.00) |
0.772 (1.00) |
0.347 (1.00) |
0.184 (0.907) |
1 (1.00) |
SLC9A6 | 5 (1%) | 506 |
0.0129 (0.386) |
0.778 (1.00) |
0.326 (1.00) |
0.456 (1.00) |
0.13 (0.876) |
1 (1.00) |
0.125 (0.876) |
0.662 (1.00) |
1 (1.00) |
0.849 (1.00) |
0.15 (0.907) |
1 (1.00) |
1 (1.00) |
|
ELF4 | 7 (1%) | 504 |
0.374 (1.00) |
0.922 (1.00) |
0.0174 (0.457) |
0.072 (0.791) |
0.217 (0.933) |
1 (1.00) |
0.68 (1.00) |
0.0213 (0.486) |
1 (1.00) |
0.423 (1.00) |
0.874 (1.00) |
0.0605 (0.773) |
1 (1.00) |
1 (1.00) |
HNRNPL | 11 (2%) | 500 |
0.48 (1.00) |
0.105 (0.87) |
0.302 (1.00) |
0.319 (1.00) |
0.104 (0.87) |
1 (1.00) |
0.177 (0.907) |
1 (1.00) |
0.213 (0.933) |
0.261 (0.961) |
0.792 (1.00) |
0.214 (0.933) |
1 (1.00) |
1 (1.00) |
ZFP36L2 | 8 (2%) | 503 |
0.131 (0.878) |
0.552 (1.00) |
0.766 (1.00) |
0.881 (1.00) |
0.307 (1.00) |
0.451 (1.00) |
1 (1.00) |
1 (1.00) |
0.661 (1.00) |
0.201 (0.933) |
0.868 (1.00) |
1 (1.00) |
0.354 (1.00) |
|
MYH9 | 21 (4%) | 490 |
0.765 (1.00) |
0.819 (1.00) |
0.862 (1.00) |
0.384 (1.00) |
0.893 (1.00) |
1 (1.00) |
0.217 (0.933) |
0.473 (1.00) |
0.373 (1.00) |
0.468 (1.00) |
0.361 (1.00) |
0.862 (1.00) |
0.44 (1.00) |
0.244 (0.961) |
NCOR1 | 17 (3%) | 494 |
0.878 (1.00) |
0.178 (0.907) |
0.759 (1.00) |
0.569 (1.00) |
0.686 (1.00) |
1 (1.00) |
0.415 (1.00) |
0.39 (1.00) |
1 (1.00) |
0.8 (1.00) |
0.261 (0.961) |
0.346 (1.00) |
0.788 (1.00) |
0.224 (0.933) |
SPTY2D1 | 10 (2%) | 501 |
0.471 (1.00) |
0.0197 (0.479) |
0.867 (1.00) |
0.624 (1.00) |
0.786 (1.00) |
1 (1.00) |
0.734 (1.00) |
0.329 (1.00) |
1 (1.00) |
0.0421 (0.63) |
0.221 (0.933) |
0.225 (0.933) |
1 (1.00) |
0.421 (1.00) |
PIWIL2 | 8 (2%) | 503 |
0.555 (1.00) |
0.275 (0.983) |
0.566 (1.00) |
0.711 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.699 (1.00) |
1 (1.00) |
0.0828 (0.836) |
0.0804 (0.83) |
0.554 (1.00) |
1 (1.00) |
1 (1.00) |
P value = 0.000124 (Wilcoxon-test), Q value = 0.036
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 2.1 (3.8) |
NSD1 MUTATED | 45 | 0.7 (1.2) |
NSD1 WILD-TYPE | 357 | 2.3 (3.9) |
P value = 7.62e-09 (Wilcoxon-test), Q value = 6.6e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
CASP8 MUTATED | 54 | 70.1 (13.3) |
CASP8 WILD-TYPE | 456 | 60.0 (11.3) |
P value = 0.000523 (Fisher's exact test), Q value = 0.11
nPatients | FEMALE | MALE |
---|---|---|
ALL | 138 | 373 |
CASP8 MUTATED | 26 | 28 |
CASP8 WILD-TYPE | 112 | 345 |
P value = 2.31e-07 (Wilcoxon-test), Q value = 1e-04
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
FAT1 MUTATED | 112 | 66.4 (11.2) |
FAT1 WILD-TYPE | 398 | 59.5 (11.7) |
P value = 0.00365 (Fisher's exact test), Q value = 0.23
nPatients | FEMALE | MALE |
---|---|---|
ALL | 138 | 373 |
FAT1 MUTATED | 43 | 69 |
FAT1 WILD-TYPE | 95 | 304 |
P value = 0.00254 (Wilcoxon-test), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
JUB MUTATED | 34 | 67.3 (10.8) |
JUB WILD-TYPE | 476 | 60.6 (11.9) |
P value = 0.0029 (Wilcoxon-test), Q value = 0.19
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 276 | 1967.3 (12.8) |
JUB MUTATED | 23 | 1958.7 (12.5) |
JUB WILD-TYPE | 253 | 1968.1 (12.6) |
P value = 0.00183 (Wilcoxon-test), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
NFE2L2 MUTATED | 27 | 68.5 (11.2) |
NFE2L2 WILD-TYPE | 483 | 60.6 (11.9) |
P value = 0.00117 (Wilcoxon-test), Q value = 0.11
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
RAC1 MUTATED | 15 | 70.8 (12.6) |
RAC1 WILD-TYPE | 495 | 60.7 (11.8) |
P value = 0.00434 (Wilcoxon-test), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 276 | 1967.3 (12.8) |
RAC1 MUTATED | 9 | 1954.9 (11.1) |
RAC1 WILD-TYPE | 267 | 1967.8 (12.7) |
P value = 0.00104 (Fisher's exact test), Q value = 0.11
nPatients | FEMALE | MALE |
---|---|---|
ALL | 138 | 373 |
RB1 MUTATED | 11 | 6 |
RB1 WILD-TYPE | 127 | 367 |
P value = 0.00234 (Fisher's exact test), Q value = 0.18
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 25 | 449 |
NAP1L2 MUTATED | 3 | 3 |
NAP1L2 WILD-TYPE | 22 | 446 |
P value = 0.000866 (Wilcoxon-test), Q value = 0.11
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
MLL4 MUTATED | 19 | 70.2 (11.3) |
MLL4 WILD-TYPE | 491 | 60.7 (11.8) |
P value = 0.00466 (Wilcoxon-test), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 290 | 45.7 (35.1) |
THSD7A MUTATED | 23 | 54.1 (17.7) |
THSD7A WILD-TYPE | 267 | 45.0 (36.1) |
P value = 0.00107 (Wilcoxon-test), Q value = 0.11
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 510 | 61.0 (12.0) |
CTCF MUTATED | 15 | 71.7 (11.4) |
CTCF WILD-TYPE | 495 | 60.7 (11.8) |
P value = 0.00398 (Fisher's exact test), Q value = 0.23
nPatients | FEMALE | MALE |
---|---|---|
ALL | 138 | 373 |
NOTCH2 MUTATED | 12 | 9 |
NOTCH2 WILD-TYPE | 126 | 364 |
P value = 0.000923 (logrank test), Q value = 0.11
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 509 | 220 | 0.1 - 211.0 (20.9) |
AK5 MUTATED | 13 | 9 | 1.1 - 32.6 (12.9) |
AK5 WILD-TYPE | 496 | 211 | 0.1 - 211.0 (21.1) |
-
Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
-
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/HNSC-TP/22815324/transformed.cor.cli.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/HNSC-TP/22506490/HNSC-TP.merged_data.txt
-
Number of patients = 511
-
Number of significantly mutated genes = 62
-
Number of selected clinical features = 14
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.