E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.003 0.084 -9999.0 0.0 -0.335 17.0 17.0 KLHL20 0.025 0.07 0.189 9.0 -0.254 6.0 15.0 CYFIP2 0.025 0.029 -9999.0 0.0 -0.425 2.0 2.0 Rac1/GDP 0.024 0.077 0.328 5.0 -0.304 1.0 6.0 ENAH -0.008 0.106 -9999.0 0.0 -0.349 26.0 26.0 AP1M1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.03 -9999.0 0.0 -0.17 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.044 -9999.0 0.0 -0.254 6.0 6.0 RAPGEF1 0.0 0.096 0.29 2.0 -0.381 5.0 7.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.109 -9999.0 0.0 -0.349 26.0 26.0 CRK 0.005 0.095 -9999.0 0.0 -0.386 8.0 8.0 E-cadherin/gamma catenin/alpha catenin 0.047 0.049 -9999.0 0.0 -0.364 6.0 6.0 alphaE/beta7 Integrin 0.038 0.025 -9999.0 0.0 -0.332 2.0 2.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.049 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.0 0.082 -9999.0 0.0 -0.354 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.002 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.045 0.036 -9999.0 0.0 -0.247 6.0 6.0 PI3K 0.006 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.034 0.052 -9999.0 0.0 -0.422 6.0 6.0 TIAM1 0.021 0.053 -9999.0 0.0 -0.463 6.0 6.0 E-cadherin(dimer)/Ca2+ 0.053 0.039 -9999.0 0.0 -0.237 5.0 5.0 AKT1 0.012 0.03 0.144 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.031 -9999.0 0.0 -0.463 2.0 2.0 CDH1 0.021 0.053 -9999.0 0.0 -0.463 6.0 6.0 RhoA/GDP 0.031 0.073 0.331 6.0 -9999.0 0.0 6.0 actin cytoskeleton organization 0.021 0.054 0.149 15.0 -0.183 6.0 21.0 CDC42/GDP 0.027 0.08 0.331 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.036 -9999.0 0.0 -0.316 5.0 5.0 ITGB7 0.026 0.031 -9999.0 0.0 -0.463 2.0 2.0 RAC1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.041 -9999.0 0.0 -0.253 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.035 -9999.0 0.0 -0.233 6.0 6.0 mol:GDP 0.013 0.085 0.341 6.0 -0.338 1.0 7.0 CDC42/GTP/IQGAP1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.031 -9999.0 0.0 -0.463 2.0 2.0 p120 catenin/RhoA/GDP 0.034 0.075 0.341 4.0 -9999.0 0.0 4.0 RAC1/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.037 0.12 4.0 -0.173 6.0 10.0 NME1 0.027 0.018 -9999.0 0.0 -0.387 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.102 -9999.0 0.0 -0.351 20.0 20.0 regulation of cell-cell adhesion 0.013 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.013 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.032 0.055 0.296 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.052 -9999.0 0.0 -0.466 2.0 2.0 CCND1 0.012 0.044 0.144 3.0 -0.213 6.0 9.0 VAV2 0.013 0.117 -9999.0 0.0 -0.555 5.0 5.0 RAP1/GDP 0.035 0.066 0.326 5.0 -9999.0 0.0 5.0 adherens junction assembly -0.005 0.099 -9999.0 0.0 -0.341 20.0 20.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.05 0.048 -9999.0 0.0 -0.441 2.0 2.0 E-cadherin/beta catenin 0.008 0.038 -9999.0 0.0 -0.337 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.007 0.102 -9999.0 0.0 -0.343 25.0 25.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.021 0.072 -9999.0 0.0 -0.369 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.044 0.041 -9999.0 0.0 -0.274 6.0 6.0 ITGAE 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.111 -9999.0 0.0 -0.356 26.0 26.0