Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.154 0.139 -9999.0 0.0 -0.544 15.0 15.0 IHH -0.038 0.058 -9999.0 0.0 -0.368 3.0 3.0 SHH Np/Cholesterol/GAS1 0.004 0.066 -9999.0 0.0 -0.208 44.0 44.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.065 0.207 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.084 0.12 -9999.0 0.0 -0.447 26.0 26.0 SMO -0.09 0.122 -9999.0 0.0 -0.469 27.0 27.0 AKT1 -0.038 0.104 -9999.0 0.0 -0.513 14.0 14.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.136 -9999.0 0.0 -0.461 44.0 44.0 ADRBK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.088 0.121 -9999.0 0.0 -0.462 27.0 27.0 STIL -0.085 0.096 -9999.0 0.0 -0.426 11.0 11.0 DHH N/PTCH2 0.03 0.059 -9999.0 0.0 -0.305 15.0 15.0 DHH N/PTCH1 -0.084 0.099 -9999.0 0.0 -0.492 8.0 8.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.021 0.029 -9999.0 0.0 -0.387 2.0 2.0 PTHLH -0.214 0.176 -9999.0 0.0 -0.594 27.0 27.0 determination of left/right symmetry -0.088 0.121 -9999.0 0.0 -0.462 27.0 27.0 PIK3R1 0.025 0.031 -9999.0 0.0 -0.463 2.0 2.0 skeletal system development -0.213 0.175 -9999.0 0.0 -0.589 27.0 27.0 IHH N/Hhip -0.032 0.084 -9999.0 0.0 -0.315 33.0 33.0 DHH N/Hhip 0.018 0.076 -9999.0 0.0 -0.275 32.0 32.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.088 0.121 -9999.0 0.0 -0.462 27.0 27.0 pancreas development -0.006 0.097 -9999.0 0.0 -0.39 30.0 30.0 HHAT 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.027 0.03 -9999.0 0.0 -0.332 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.051 -9999.0 0.0 -0.409 7.0 7.0 somite specification -0.088 0.121 -9999.0 0.0 -0.462 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.089 0.096 -9999.0 0.0 -0.346 31.0 31.0 SHH Np/Cholesterol/PTCH2 0.001 0.075 -9999.0 0.0 -0.226 48.0 48.0 SHH Np/Cholesterol/Megalin -0.007 0.081 -9999.0 0.0 -0.233 52.0 52.0 SHH -0.018 0.073 -9999.0 0.0 -0.273 38.0 38.0 catabolic process -0.099 0.103 -9999.0 0.0 -0.434 14.0 14.0 SMO/Vitamin D3 -0.085 0.109 -9999.0 0.0 -0.457 14.0 14.0 SHH Np/Cholesterol/Hhip -0.01 0.084 -9999.0 0.0 -0.231 60.0 60.0 LRP2 -0.001 0.091 -9999.0 0.0 -0.388 26.0 26.0 receptor-mediated endocytosis -0.087 0.108 -9999.0 0.0 -0.466 15.0 15.0 SHH Np/Cholesterol/BOC -0.015 0.092 -9999.0 0.0 -0.236 73.0 73.0 SHH Np/Cholesterol/CDO 0.0 0.07 -9999.0 0.0 -0.215 48.0 48.0 mesenchymal cell differentiation 0.01 0.084 0.23 60.0 -9999.0 0.0 60.0 mol:Vitamin D3 -0.086 0.103 0.371 1.0 -0.384 19.0 20.0 IHH N/PTCH2 -0.02 0.069 -9999.0 0.0 -0.336 16.0 16.0 CDON 0.016 0.068 -9999.0 0.0 -0.463 10.0 10.0 IHH N/PTCH1 -0.097 0.107 -9999.0 0.0 -0.436 14.0 14.0 Megalin/LRPAP1 0.022 0.068 -9999.0 0.0 -0.268 26.0 26.0 PTCH2 0.016 0.073 -9999.0 0.0 -0.434 13.0 13.0 SHH Np/Cholesterol -0.001 0.058 -9999.0 0.0 -0.205 38.0 38.0 PTCH1 -0.099 0.104 -9999.0 0.0 -0.435 14.0 14.0 HHIP -0.006 0.098 -9999.0 0.0 -0.391 30.0 30.0