Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.02 0.032 -9999.0 0.0 -0.246 6.0 6.0 epithelial cell differentiation 0.048 0.037 -9999.0 0.0 -0.235 5.0 5.0 CYFIP2 0.025 0.029 -9999.0 0.0 -0.425 2.0 2.0 ENAH 0.019 0.07 0.233 11.0 -0.463 1.0 12.0 EGFR 0.02 0.044 -9999.0 0.0 -0.463 4.0 4.0 EPHA2 0.021 0.053 -9999.0 0.0 -0.463 6.0 6.0 MYO6 0.017 0.036 0.21 2.0 -9999.0 0.0 2.0 CTNNB1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.026 -9999.0 0.0 -0.255 2.0 2.0 AQP5 -0.266 0.222 -9999.0 0.0 -0.455 271.0 271.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.017 0.037 0.208 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.062 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.067 0.192 -9999.0 0.0 -0.462 98.0 98.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.092 0.191 -9999.0 0.0 -0.462 88.0 88.0 cortical microtubule organization 0.048 0.037 -9999.0 0.0 -0.235 5.0 5.0 GO:0000145 -0.002 0.037 0.195 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.039 -9999.0 0.0 -0.237 5.0 5.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.012 0.028 -9999.0 0.0 -0.399 1.0 1.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.041 -9999.0 0.0 -0.257 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.007 0.03 0.211 1.0 -9999.0 0.0 1.0 PVRL2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.016 0.036 0.21 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.057 0.044 -9999.0 0.0 -0.24 4.0 4.0 CDH1 0.021 0.053 -9999.0 0.0 -0.463 6.0 6.0 EGFR/EGFR/EGF/EGF -0.01 0.106 -9999.0 0.0 -0.386 4.0 4.0 RhoA/GDP 0.049 0.036 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.002 0.036 0.194 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.053 0.181 -9999.0 0.0 -0.459 85.0 85.0 DIAPH1 0.019 0.12 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.048 0.037 0.235 5.0 -9999.0 0.0 5.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.012 0.028 -9999.0 0.0 -0.399 1.0 1.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.002 0.037 0.196 2.0 -9999.0 0.0 2.0 EFNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.003 0.031 0.199 2.0 -9999.0 0.0 2.0 Ephrin A1/EPHA2 0.039 0.045 -9999.0 0.0 -0.436 1.0 1.0 SEC6/SEC8 0.01 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.062 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET 0.029 0.067 -9999.0 0.0 -0.381 3.0 3.0 HGF 0.006 0.095 -9999.0 0.0 -0.439 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.02 0.032 -9999.0 0.0 -0.248 6.0 6.0 actin cable formation 0.058 0.095 0.228 81.0 -0.327 1.0 82.0 KIAA1543 -0.014 0.064 0.197 3.0 -0.378 4.0 7.0 KIFC3 0.014 0.032 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.016 0.036 0.21 2.0 -9999.0 0.0 2.0 NCK1/GIT1 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.037 -9999.0 0.0 -0.235 5.0 5.0 EXOC4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.017 0.037 0.21 2.0 -9999.0 0.0 2.0 PIP5K1C 0.017 0.038 0.21 2.0 -9999.0 0.0 2.0 LIMA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.025 0.078 0.27 10.0 -0.353 1.0 11.0 adherens junction assembly -0.01 0.096 0.276 6.0 -0.503 8.0 14.0 IGF-1R heterotetramer/IGF1 0.002 0.1 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.022 0.048 -9999.0 0.0 -0.412 6.0 6.0 PLEKHA7 0.003 0.07 0.21 2.0 -0.396 4.0 6.0 mol:GTP 0.052 0.04 -9999.0 0.0 -0.256 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.024 0.082 0.332 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.02 0.032 -9999.0 0.0 -0.246 6.0 6.0 regulation of cell-cell adhesion -0.002 0.036 0.194 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.02 0.032 -9999.0 0.0 -0.248 6.0 6.0