Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.096 0.191 -9999.0 0.0 -0.53 11.0 11.0 IHH -0.048 0.107 -9999.0 0.0 -0.229 17.0 17.0 SHH Np/Cholesterol/GAS1 0.012 0.06 -9999.0 0.0 -0.27 2.0 2.0 LRPAP1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.012 0.06 0.268 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.052 0.123 -9999.0 0.0 -0.364 3.0 3.0 SMO -0.057 0.12 -9999.0 0.0 -0.39 3.0 3.0 AKT1 -0.024 0.147 -9999.0 0.0 -0.549 5.0 5.0 ARRB2 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.108 -9999.0 0.0 -0.383 6.0 6.0 ADRBK1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 STIL -0.03 0.093 -9999.0 0.0 -0.282 2.0 2.0 DHH N/PTCH2 0.042 0.039 -9999.0 0.0 -0.292 1.0 1.0 DHH N/PTCH1 -0.047 0.114 -9999.0 0.0 -0.267 12.0 12.0 PIK3CA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.049 -9999.0 0.0 -0.415 1.0 1.0 PTHLH -0.159 0.309 -9999.0 0.0 -0.915 11.0 11.0 determination of left/right symmetry -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 PIK3R1 0.015 0.086 -9999.0 0.0 -0.367 4.0 4.0 skeletal system development -0.157 0.306 -9999.0 0.0 -0.903 11.0 11.0 IHH N/Hhip -0.036 0.105 -9999.0 0.0 -0.209 17.0 17.0 DHH N/Hhip 0.012 0.091 -9999.0 0.0 -0.189 13.0 13.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 pancreas development -0.012 0.108 -9999.0 0.0 -0.249 14.0 14.0 HHAT 0.02 0.054 -9999.0 0.0 -0.222 4.0 4.0 PI3K 0.034 0.067 -9999.0 0.0 -0.292 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.003 0.1 -9999.0 0.0 -0.294 8.0 8.0 somite specification -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.037 0.087 -9999.0 0.0 -0.267 1.0 1.0 SHH Np/Cholesterol/PTCH2 0.024 0.046 -9999.0 0.0 -0.318 1.0 1.0 SHH Np/Cholesterol/Megalin -0.016 0.103 -9999.0 0.0 -0.235 15.0 15.0 SHH 0.011 0.05 -9999.0 0.0 -0.41 1.0 1.0 catabolic process -0.063 0.123 -9999.0 0.0 -0.309 12.0 12.0 SMO/Vitamin D3 -0.045 0.094 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip 0.005 0.073 -9999.0 0.0 -0.285 3.0 3.0 LRP2 -0.051 0.174 -9999.0 0.0 -0.415 16.0 16.0 receptor-mediated endocytosis -0.07 0.123 -9999.0 0.0 -0.368 4.0 4.0 SHH Np/Cholesterol/BOC 0.013 0.078 -9999.0 0.0 -0.296 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.064 -9999.0 0.0 -0.249 4.0 4.0 mesenchymal cell differentiation -0.005 0.072 0.284 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.028 0.094 -9999.0 0.0 -0.265 1.0 1.0 IHH N/PTCH2 -0.004 0.072 -9999.0 0.0 -0.183 2.0 2.0 CDON 0.0 0.117 -9999.0 0.0 -0.387 7.0 7.0 IHH N/PTCH1 -0.058 0.129 -9999.0 0.0 -0.31 12.0 12.0 Megalin/LRPAP1 -0.016 0.133 -9999.0 0.0 -0.292 16.0 16.0 PTCH2 0.027 0.049 -9999.0 0.0 -0.415 1.0 1.0 SHH Np/Cholesterol 0.013 0.039 -9999.0 0.0 -0.318 1.0 1.0 PTCH1 -0.063 0.123 -9999.0 0.0 -0.309 12.0 12.0 HHIP -0.012 0.108 -9999.0 0.0 -0.249 14.0 14.0