Clinical Features Time to Death YEARS_TO_BIRTH PATHOLOGIC_STAGE PATHOLOGY_T_STAGE PATHOLOGY_N_STAGE PATHOLOGY_M_STAGE GENDER KARNOFSKY_PERFORMANCE_SCORE HISTOLOGICAL_TYPE NUMBER_PACK_YEARS_SMOKED YEAR_OF_TOBACCO_SMOKING_ONSET RACE ETHNICITY nMutated (%) nWild-Type logrank test_P logrank test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 38 (5%) 746 0.60508 1 0.26786 1 0.0031 0.166 0.00241 0.166 0.02226 0.422 0.76825 1 0.38045 1 0.4638 1 9.9999e-06 0.00152 0.37768 1 0.80199 1 0.20391 1 1 1 PTEN 28 (4%) 756 0.7272 1 0.57781 1 0.26812 1 0.27801 1 0.1599 0.99 0.34315 1 0.53933 1 0.78688 1 0.04428 0.601 0.43373 1 0.73058 1 0.32447 1 1 1 SETD2 61 (8%) 723 0.034669 0.535 0.053709 0.652 0.0061899 0.256 0.0084499 0.31 1 1 0.14176 0.915 0.47815 1 0.90957 1 0.04142 0.601 0.91776 1 NA NA 0.50935 1 0.50674 1 PBRM1 143 (18%) 641 0.094029 0.794 0.023046 0.428 0.22196 1 0.22468 1 0.055049 0.659 0.4819 1 0.76788 1 0.29819 1 9.9999e-06 0.00152 0.26 1 NA NA 0.01395 0.337 0.81908 1 NEFH 12 (2%) 772 0.52539 1 0.69516 1 0.2834 1 0.62438 1 1 1 0.63884 1 0.11676 0.853 0.73289 1 0.59808 1 NA NA NA NA 1 1 1 1 VHL 196 (25%) 588 0.0045024 0.214 0.28185 1 0.40906 1 0.20529 1 0.02619 0.461 0.70427 1 0.096434 0.794 0.65076 1 9.9999e-06 0.00152 NA NA NA NA 9.9999e-06 0.00152 1 1 NF2 16 (2%) 768 0.078342 0.778 0.34068 1 0.01367 0.337 0.067159 0.71 0.00025 0.0253 0.15507 0.967 0.78893 1 0.89592 1 0.089989 0.794 0.39447 1 0.79645 1 0.20161 1 0.53304 1 MET 25 (3%) 759 0.77971 1 0.49734 1 0.51424 1 0.63265 1 0.14026 0.912 1 1 0.67086 1 0.091837 0.794 9.9999e-06 0.00152 0.41574 1 0.18359 1 0.82233 1 1 1 KDM5C 27 (3%) 757 0.017104 0.362 0.057438 0.67 0.53633 1 0.60016 1 0.76866 1 0.77518 1 0.058284 0.67 NA NA 7.9999e-05 0.0104 NA NA NA NA 0.63612 1 0.63125 1 MTOR 34 (4%) 750 0.074454 0.77 0.11712 0.853 0.32272 1 0.60713 1 1 1 0.18098 1 0.0049313 0.214 0.010852 0.337 0.00253 0.166 NA NA NA NA 0.7948 1 0.71266 1 ZNF814 14 (2%) 770 0.34585 1 0.43899 1 0.13456 0.912 0.45544 1 0.43429 1 1 1 0.56673 1 NA NA 0.00301 0.166 0.1849 1 NA NA 0.75012 1 1 1 AR 15 (2%) 769 0.59886 1 0.37309 1 0.53409 1 0.54229 1 0.57944 1 1 1 0.58404 1 0.4638 1 0.00014 0.0159 0.99251 1 0.94288 1 1 1 1 1 STAG2 15 (2%) 769 0.9062 1 0.013207 0.337 0.0279 0.462 0.01812 0.366 0.51383 1 0.65898 1 0.27321 1 NA NA 0.47388 1 NA NA NA NA 0.73326 1 1 1 KRAS 6 (1%) 778 0.2957 1 0.64877 1 0.6885 1 0.55926 1 NA NA 1 1 0.016452 0.362 NA NA 0.058939 0.67 NA NA NA NA 0.0071299 0.282 1 1 SLC6A14 4 (1%) 780 0.35851 1 0.20322 1 0.04776 0.613 0.04191 0.601 0.04592 0.612 1 1 0.60169 1 NA NA 0.51192 1 NA NA NA NA 1 1 1 1 SMARCA4 20 (3%) 764 0.71949 1 0.4938 1 0.83216 1 0.96381 1 1 1 0.68075 1 0.33418 1 0.4689 1 0.42201 1 NA NA NA NA 0.66324 1 0.61581 1 NFE2L2 12 (2%) 772 0.92392 1 0.013119 0.337 0.76848 1 0.66919 1 0.63332 1 1 1 0.75982 1 NA NA 0.59796 1 NA NA NA NA 0.13808 0.912 1 1 ARID1A 18 (2%) 766 0.63339 1 0.94169 1 0.095119 0.794 0.34267 1 0.27926 1 0.70434 1 0.61552 1 0.55314 1 0.50554 1 NA NA NA NA 0.01222 0.337 0.20749 1 BCLAF1 10 (1%) 774 0.35661 1 0.35296 1 0.04323 0.601 0.1403 0.912 0.17532 1 1 1 1 1 NA NA 0.03858 0.585 NA NA NA NA 0.68849 1 1 1 ATM 20 (3%) 764 0.38607 1 0.22802 1 0.082109 0.794 0.076389 0.778 1 1 0.45514 1 0.47952 1 0.4638 1 0.3414 1 0.97979 1 NA NA 0.31322 1 0.58935 1 CACNA1C 15 (2%) 769 0.48189 1 0.50959 1 0.01538 0.359 0.24907 1 0.01693 0.362 0.0049374 0.214 1 1 NA NA 0.13851 0.912 NA NA NA NA 1 1 0.46925 1 PARD6B 8 (1%) 776 0.48249 1 0.0090996 0.31 0.61815 1 0.80331 1 NA NA 1 1 0.058223 0.67 NA NA 0.096819 0.794 NA NA NA NA 0.092239 0.794 1 1 CUL3 16 (2%) 768 0.099554 0.803 0.96373 1 0.97754 1 0.65544 1 0.065609 0.705 1 1 0.10614 0.803 0.4638 1 0.088669 0.794 0.010535 0.337 0.21837 1 0.78522 1 0.58935 1 PIK3CA 15 (2%) 769 0.74526 1 0.19505 1 0.14971 0.953 0.096479 0.794 1 1 0.19248 1 0.27321 1 NA NA 0.6236 1 NA NA NA NA 1 1 0.56208 1 SMARCB1 9 (1%) 775 0.76403 1 0.061311 0.683 0.203 1 0.096489 0.794 0.51043 1 1 1 0.72538 1 NA NA 0.087389 0.794 NA NA NA NA 1 1 1 1 PCF11 13 (2%) 771 0.84821 1 0.2001 1 0.50109 1 0.40678 1 NA NA 0.62146 1 0.56175 1 NA NA 0.0015 0.124 0.65075 1 NA NA 0.73054 1 0.46925 1 WASL 8 (1%) 776 0.97105 1 0.2514 1 0.51009 1 0.72937 1 1 1 1 1 1 1 NA NA 0.53503 1 NA NA NA NA 0.6721 1 1 1 DNMT3A 11 (1%) 773 0.28241 1 0.60279 1 0.30549 1 0.33043 1 0.57743 1 1 1 0.7573 1 NA NA 0.72342 1 NA NA NA NA 1 1 0.46925 1 KIAA0922 7 (1%) 777 0.89524 1 0.16328 0.997 0.18241 1 0.15463 0.967 NA NA 1 1 0.10253 0.803 NA NA 0.20563 1 NA NA NA NA 0.56575 1 1 1 GPR50 5 (1%) 779 0.37045 1 0.36574 1 0.82466 1 0.85466 1 NA NA 1 1 0.33807 1 NA NA 0.45973 1 NA NA NA NA 0.5015 1 1 1 ACSF2 11 (1%) 773 0.0091903 0.31 0.72662 1 0.25364 1 0.45881 1 0.43528 1 0.089039 0.794 1 1 0.78688 1 0.72536 1 NA NA NA NA 0.061589 0.683 1 1 WDR52 9 (1%) 775 0.74933 1 0.1022 0.803 0.31909 1 0.28156 1 1 1 0.20167 1 1 1 NA NA 0.77189 1 NA NA NA NA 0.3914 1 0.43426 1 ALMS1 14 (2%) 770 0.36272 1 0.24219 1 0.81015 1 1 1 1 1 0.31382 1 0.043573 0.601 NA NA 0.26459 1 NA NA NA NA 0.28067 1 0.16222 0.997 TXNIP 8 (1%) 776 0.76321 1 0.7427 1 0.03402 0.535 0.03428 0.535 0.0091199 0.31 0.25762 1 0.72252 1 NA NA 1 1 NA NA NA NA 1 1 0.35742 1 NUDT11 5 (1%) 779 0.52087 1 0.22148 1 0.60828 1 0.47318 1 NA NA 1 1 1 1 NA NA 0.77772 1 NA NA NA NA 1 1 1 1 PCK1 9 (1%) 775 0.62568 1 0.47851 1 0.94904 1 0.2613 1 1 1 1 1 1 1 NA NA 0.41859 1 NA NA NA NA 1 1 1 1 RAI1 11 (1%) 773 0.80834 1 0.37915 1 0.27946 1 0.10667 0.803 NA NA 0.36642 1 0.35513 1 NA NA 0.10226 0.803 NA NA NA NA 0.68858 1 1 1 PAM 4 (1%) 780 0.23608 1 0.89628 1 0.67718 1 1 1 0.3508 1 1 1 1 1 NA NA 0.40164 1 NA NA 0.44805 1 0.34188 1 1 1 KDM6A 13 (2%) 771 0.40579 1 0.00054191 0.0493 0.56653 1 0.94008 1 1 1 0.37132 1 0.76721 1 0.48062 1 0.0125 0.337 0.16438 0.997 NA NA 0.051489 0.633 1 1 GLS 9 (1%) 775 0.82876 1 0.93052 1 0.94831 1 0.065819 0.705 NA NA 0.59961 1 1 1 NA NA 0.34913 1 NA NA NA NA 1 1 1 1 EPS15L1 10 (1%) 774 0.96144 1 0.026471 0.461 0.02685 0.461 0.11947 0.856 1 1 0.60102 1 0.51088 1 NA NA 0.79633 1 NA NA NA NA 0.20425 1 0.046371 0.612 NOM1 6 (1%) 778 0.32716 1 0.46393 1 1 1 0.094779 0.794 0.43682 1 1 1 0.66959 1 NA NA 0.53669 1 NA NA NA NA 0.56667 1 1 1 CDK12 8 (1%) 776 0.99538 1 0.049838 0.621 0.5915 1 0.72746 1 1 1 0.31382 1 0.44984 1 NA NA 0.31295 1 NA NA NA NA 1 1 1 1 ARHGAP35 7 (1%) 777 0.12348 0.858 0.74462 1 0.10435 0.803 0.2058 1 1 1 0.20167 1 0.68963 1 NA NA 0.39471 1 NA NA NA NA 0.04285 0.601 1 1 RIMBP3 5 (1%) 779 0.27732 1 0.35838 1 0.66718 1 0.078649 0.778 1 1 1 1 0.33807 1 NA NA 0.03362 0.535 NA NA NA NA 1 1 1 1 FAT1 20 (3%) 764 0.77549 1 0.33745 1 0.30287 1 0.37954 1 0.22955 1 0.65898 1 1 1 0.89592 1 0.077889 0.778 0.68692 1 0.40321 1 0.52292 1 0.61581 1 FAM178A 8 (1%) 776 1.4795e-09 1.35e-06 0.089003 0.794 0.37299 1 0.59735 1 NA NA 0.59961 1 0.12292 0.858 NA NA 0.7476 1 NA NA NA NA 1 1 0.31528 1 TCEB1 4 (1%) 780 0.19509 1 0.088657 0.794 0.80608 1 0.40557 1 NA NA 1 1 1 1 NA NA 1 1 NA NA NA NA 0.42697 1 0.2228 1 PODXL 6 (1%) 778 0.24717 1 0.040582 0.601 0.32155 1 0.4761 1 1 1 1 1 0.66959 1 NA NA 0.53944 1 0.5678 1 0.17206 1 0.11019 0.815 1 1 DNAJA3 3 (0%) 781 0.39079 1 0.87434 1 0.55806 1 0.28801 1 NA NA 1 1 0.25332 1 NA NA 0.6669 1 NA NA NA NA NA NA 1 1 NASP 5 (1%) 779 0.43413 1 0.3172 1 0.32556 1 0.4732 1 NA NA 1 1 0.33807 1 NA NA 0.04918 0.621 NA NA NA NA 1 1 0.27046 1 SLC23A1 6 (1%) 778 0.12252 0.858 0.96295 1 0.43482 1 0.29651 1 1 1 0.53329 1 0.40115 1 NA NA 1 1 NA NA NA NA 0.23937 1 1 1 RILPL1 5 (1%) 779 0.57226 1 0.99045 1 0.12174 0.858 0.33037 1 0.34813 1 0.45614 1 1 1 NA NA 0.04781 0.613 NA NA NA NA 0.18931 1 1 1 NIPBL 15 (2%) 769 0.87489 1 0.61699 1 0.139 0.912 0.063599 0.697 0.51279 1 0.37132 1 0.40765 1 0.78688 1 0.15303 0.967 0.17948 1 0.30157 1 1 1 1 1 FAM47A 6 (1%) 778 0.0029919 0.166 0.40559 1 0.57632 1 0.47398 1 NA NA 0.45614 1 0.016452 0.362 NA NA 0.42551 1 NA NA NA NA 1 1 1 1 RHEB 3 (0%) 781 0.74474 1 0.95079 1 0.4552 1 0.57384 1 NA NA 0.26211 1 0.25332 1 NA NA 1 1 NA NA NA NA 0.34057 1 1 1 BRAF 5 (1%) 779 0.66724 1 0.60127 1 0.86454 1 1 1 NA NA 0.36642 1 0.66616 1 NA NA 0.20129 1 NA NA NA NA 1 1 1 1 MLL3 42 (5%) 742 0.79077 1 0.982 1 0.093149 0.794 0.082549 0.794 1 1 1 1 0.17747 1 0.6549 1 0.00301 0.166 0.48875 1 0.32704 1 0.00464 0.214 0.71273 1 ANK3 22 (3%) 762 0.12815 0.883 0.6383 1 0.46172 1 0.5672 1 0.57919 1 0.71228 1 0.10594 0.803 0.32001 1 0.8462 1 0.13557 0.912 0.3893 1 0.54034 1 1 1 EMG1 4 (1%) 780 0.21215 1 0.82886 1 0.58887 1 0.40198 1 NA NA 1 1 1 1 NA NA 0.2947 1 NA NA NA NA 1 1 1 1 LHX1 4 (1%) 780 0.7292 1 0.8124 1 0.02407 0.438 0.17498 1 NA NA 1 1 0.1068 0.803 NA NA 0.51058 1 NA NA NA NA 1 1 0.17211 1 SCARB2 4 (1%) 780 0.19156 1 0.027373 0.461 0.14558 0.933 0.13571 0.912 NA NA 1 1 1 1 NA NA 0.29545 1 NA NA NA NA 1 1 1 1 C1ORF25 6 (1%) 778 0.067886 0.71 0.01409 0.337 0.57605 1 0.083289 0.794 1 1 1 1 1 1 NA NA 0.54143 1 NA NA NA NA 1 1 1 1 KDELR3 7 (1%) 777 0.24928 1 0.49532 1 0.23598 1 0.01261 0.337 1 1 1 1 0.43595 1 NA NA 0.10771 0.803 NA NA NA NA 0.62228 1 1 1 TTLL6 4 (1%) 780 0.81265 1 0.51668 1 0.01228 0.337 0.01761 0.364 NA NA 1 1 0.1068 0.803 NA NA 0.02044 0.403 NA NA NA NA 1 1 1 1 STXBP3 5 (1%) 779 0.72717 1 0.78927 1 0.4104 1 0.18934 1 NA NA 0.36642 1 1 1 NA NA 0.60454 1 NA NA NA NA 1 1 0.27046 1 FAM20C 5 (1%) 779 0.44574 1 0.52593 1 0.45309 1 0.38887 1 1 1 1 1 0.33807 1 NA NA 0.02081 0.403 NA NA NA NA 1 1 1 1 CCBL2 3 (0%) 781 0.1963 1 0.31344 1 0.55656 1 0.28878 1 NA NA 1 1 0.25332 1 NA NA 0.66705 1 NA NA NA NA 0.33965 1 1 1 B3GNT6 3 (0%) 781 0.73634 1 0.51117 1 0.80465 1 0.73259 1 NA NA 1 1 0.55475 1 NA NA 0.66878 1 NA NA NA NA 0.34079 1 0.11821 0.854 HNF1B 4 (1%) 780 0.17315 1 0.70398 1 0.32208 1 0.3222 1 NA NA 0.26211 1 0.60169 1 NA NA 0.51136 1 NA NA NA NA 1 1 1 1