rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), BTRC(4), CDC16(4), CDC20(3), CDC23(3), CDC27(10), CUL1(5), CUL2(4), CUL3(17), FBXW11(1), FBXW7(5), FZR1(4), ITCH(1), RBX1(1), SKP2(2), SMURF1(1), SMURF2(4), TCEB1(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(241), WWP1(7), WWP2(4) 48311765 355 309 250 22 15 20 45 104 167 4 4.76e-12 <1.00e-15 <3.08e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), FLT1(8), FLT4(15), HIF1A(5), HRAS(1), KDR(6), NOS3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PXN(3), SHC1(4), VHL(241) 40195015 331 284 225 25 21 26 34 87 161 2 7.36e-10 <1.00e-15 <3.08e-13 3 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(1), COPS5(2), CREB1(1), EP300(16), HIF1A(5), JUN(2), NOS3(3), P4HB(2), VHL(241) 19872252 275 249 173 15 9 11 29 72 152 2 1.70e-09 1.67e-15 3.42e-13 4 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(3), TP53(50), WT1(3) 8263058 66 56 57 5 4 7 6 21 24 4 0.000553 4.31e-14 6.63e-12 5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), NXT1(1), PRB1(6), TP53(50) 9636795 81 65 64 7 4 6 9 20 37 5 0.00144 8.19e-14 1.01e-11 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), DNAJC3(2), EIF2S2(2), NFKB1(1), NFKBIA(1), RELA(7), TP53(50) 11781948 65 54 53 3 4 10 5 17 24 5 8.72e-05 6.90e-11 7.08e-09 7 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(6), AKT1(1), ATM(23), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIC1(1), HIF1A(5), HSPA1A(1), IGFBP3(1), NFKBIB(2), TP53(50) 24711057 103 87 90 7 7 12 11 30 37 6 2.22e-05 2.43e-08 2.14e-06 8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(4), AKT3(2), BPNT1(3), GRB2(3), ILK(4), MAPK1(1), MAPK3(3), PDK1(1), PIK3CA(16), PIK3CD(2), PTEN(35), PTK2B(4), RBL2(3), SHC1(4), SOS1(7) 23851936 93 81 85 5 7 18 9 22 33 4 6.87e-06 2.08e-07 1.60e-05 9 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(4), ATM(23), BAX(1), CCNE1(1), CDK2(2), CDK4(7), CDKN1A(3), E2F1(1), PCNA(3), RB1(4), TIMP3(4), TP53(50) 21482122 103 75 87 9 6 10 11 25 44 7 0.000712 7.01e-06 0.000479 10 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CDK2(2), CDK4(7), CHEK1(1), MYT1(9), RB1(4), TP53(50), WEE1(2) 21017184 105 83 92 12 7 16 13 29 34 6 0.000996 0.000297 0.0183 11 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(6), CDKN2A(4), E2F1(1), MYC(1), PIK3CA(16), PIK3R1(5), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), RB1(4), TP53(50) 23457521 104 85 89 11 7 21 7 31 32 6 0.000115 0.000339 0.0190 12 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), HSPA1A(1), IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(1), NFKBIA(1), RB1(4), RELA(7), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TP53(50), USH1C(4), WT1(3) 21895962 95 79 83 10 5 10 8 27 38 7 0.00319 0.000487 0.0250 13 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(6) 2581011 18 17 12 3 1 3 1 3 9 1 0.617 0.00994 0.471 14 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(3), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4) 6407869 17 17 16 0 3 3 6 5 0 0 0.00312 0.0139 0.575 15 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(2), GLS(9), GLUD1(1), OAT(3), PRODH(2) 6632902 19 19 19 0 1 2 9 3 4 0 0.00600 0.0140 0.575 16 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(5), CDKN1B(1), GRB2(3), ILK(4), ITGB1(6), MAPK1(1), MAPK3(3), PDK2(4), PIK3CA(16), PIK3R1(5), PTEN(35), PTK2(3), SHC1(4), SOS1(7) 22810884 98 84 90 14 7 17 7 23 39 5 0.0361 0.0203 0.781 17 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(5), GLS(9), GLUD1(1), GOT1(3) 9142446 24 24 24 1 0 4 5 7 8 0 0.0266 0.0218 0.791 18 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), KARS(1) 8277290 21 21 21 1 0 5 5 7 4 0 0.0264 0.0257 0.875 19 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(1), CD3G(2), CD4(10) 3850233 15 15 9 1 1 1 1 3 8 1 0.476 0.0270 0.875 20 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(9), GLS2(4), GLUD1(1), GLUD2(1) 5253148 15 15 15 0 1 2 4 6 2 0 0.0228 0.0303 0.932 21 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4E(2), GSK3B(3), IGF1R(4), INPPL1(4), PDK2(4), PIK3CA(16), PIK3R1(5), PPP2CA(1), PTEN(35), RPS6KB1(2) 23477583 84 74 76 10 7 13 6 19 35 4 0.0106 0.0327 0.960 22 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(9), KARS(1) 5630342 15 15 15 1 0 3 4 5 3 0 0.0923 0.0401 1.000 23 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(4), AKT3(2), CDKN1A(3), ELK1(2), GRB2(3), HRAS(1), MAP2K2(1), NGFR(2), NTRK1(6), PIK3CA(16), PIK3CD(2), SHC1(4), SOS1(7) 18793182 54 52 47 5 4 16 3 22 8 1 0.000711 0.0425 1.000 24 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 605111 3 3 3 0 0 0 0 1 2 0 0.858 0.0540 1.000 25 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(3), GOT2(3), TAT(3), TYR(5) 5574296 17 17 17 2 3 1 3 4 6 0 0.255 0.0558 1.000 26 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(13), DAXX(6), HRAS(1), PAX3(2), PML(3), RARA(4), RB1(4), SIRT1(5), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TP53(50) 21851266 94 80 85 15 9 10 12 28 29 6 0.0124 0.0619 1.000 27 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(8), EGF(5), EGFR(10), GRB2(3), MET(28), PDGFRA(6), PRKCA(3), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(2) 23003961 74 67 62 9 6 14 13 24 17 0 0.00534 0.0634 1.000 28 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(3), RANBP1(2), RANBP2(26), RANGAP1(1) 9694037 32 29 26 3 2 7 4 9 10 0 0.0261 0.0652 1.000 29 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(3), TAT(3) 3127345 9 9 9 1 2 1 2 0 4 0 0.339 0.0768 1.000 30 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(3), EHHADH(6), HADHA(4) 5764259 14 14 13 1 1 3 5 3 2 0 0.0453 0.102 1.000 31 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(4), SHMT1(4), SHMT2(6) 4859216 14 14 14 2 2 1 3 4 4 0 0.226 0.104 1.000 32 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(2), PDXP(2), PSAT1(2) 5648478 14 14 14 1 3 1 1 6 3 0 0.147 0.104 1.000 33 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4) 9971050 22 22 21 1 1 4 6 8 3 0 0.00990 0.110 1.000 34 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(10), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL2(1), IL4(1) 4468504 21 20 15 4 2 3 2 4 9 1 0.577 0.122 1.000 35 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FOS(1), FYN(2), JUN(2), MAPK14(2), THBS1(16) 8481542 23 21 20 2 1 2 5 8 7 0 0.119 0.122 1.000 36 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(10), CD58(1), CD8A(1), IL3(1), KITLG(2) 7383119 22 20 16 2 1 2 2 5 11 1 0.382 0.136 1.000 37 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(23), ATR(11), CDC25C(4), CHEK1(1), CHEK2(3), TP53(50) 18985809 92 75 82 13 7 12 10 28 31 4 0.0231 0.153 1.000 38 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), CDC42(1), PAK1(4), PDGFRA(6), PIK3CA(16), PIK3R1(5), WASL(9) 15936942 53 51 41 7 4 12 5 17 15 0 0.0357 0.175 1.000 39 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(5) 2038596 7 7 7 2 1 1 0 4 1 0 0.687 0.211 1.000 40 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(10), IGF1R(4), MYC(1), POLR2A(11), PPP2CA(1), PRKCA(3), RB1(4), TEP1(10), TERF1(1), TERT(10), TNKS(5), TP53(50), XRCC5(5) 32958243 116 90 105 17 13 16 12 33 36 6 0.00127 0.215 1.000 41 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ECHS1(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(1) 9237301 20 20 17 1 2 4 5 4 5 0 0.0205 0.222 1.000 42 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(1), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(6), ITGB2(2), PRF1(1) 9870315 24 23 24 2 0 5 3 10 6 0 0.0538 0.229 1.000 43 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), GPD2(2), NDUFA1(1), SDHA(8), SDHB(1), SDHD(2), UQCRC1(2) 7707246 20 18 20 3 4 7 3 5 1 0 0.0813 0.240 1.000 44 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(2), RAB3A(3), RAB4A(1), RAB5A(1), RAB6A(2) 4994451 11 11 11 1 1 1 1 5 3 0 0.261 0.244 1.000 45 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(1) 1808576 4 4 4 1 0 0 0 2 2 0 0.815 0.265 1.000 46 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(6), IL18(1), ITGB1(6), KLRC1(2), KLRC2(3), KLRC3(2), MAPK3(3), PAK1(4), PIK3CA(16), PIK3R1(5), PTK2B(4), PTPN6(3), SYK(2), VAV1(6) 22107815 66 59 59 9 5 16 6 19 19 1 0.0233 0.267 1.000 47 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), AMD1(2), BHMT(5), CBS(1), CTH(2), DNMT1(23), DNMT3A(17), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), MTR(1), TAT(3) 24325326 73 66 54 10 6 5 9 16 37 0 0.171 0.307 1.000 48 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), RDH11(4), RDH12(3), RDH13(1) 5560033 12 12 12 1 1 1 1 8 1 0 0.203 0.315 1.000 49 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(7), EGF(5), EGFR(10), HGS(4), RAB5A(1), TF(1), TFRC(4) 15072760 32 31 30 3 5 1 6 9 11 0 0.0661 0.317 1.000 50 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(1), EIF4A2(6), EIF4B(4), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(4), PIK3CA(16), PIK3R1(5), PPP2CA(1), PTEN(35), RPS6KB1(2), TSC1(5), TSC2(14) 32919216 118 106 110 18 8 19 12 32 40 7 0.0187 0.327 1.000 51 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT2(4), AKT3(2), CDKN2A(4), DAPP1(1), GRB2(3), GSK3A(1), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PIK3CA(16), PPP1R13B(6), PTEN(35), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SOS1(7), SOS2(7), TEC(5), YWHAB(1) 42224854 121 107 109 16 6 21 13 31 45 5 0.00410 0.339 1.000 52 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CAMKK1(5), CAMKK2(3), CREB1(1), SYT1(1) 13707613 29 29 28 3 3 4 4 9 9 0 0.0645 0.350 1.000 53 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(5), CBS(1), CTH(2), DNMT1(23), DNMT3A(17), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTR(1) 20371255 65 59 46 7 3 4 7 14 37 0 0.135 0.371 1.000 54 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(6), ATM(23), ATR(11), CCNA1(7), CCNE1(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(2), TGFB2(2), TP53(50) 35461208 132 101 114 21 8 15 15 33 54 7 0.0102 0.374 1.000 55 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(2) 1381597 3 3 3 0 0 0 1 1 1 0 0.585 0.387 1.000 56 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(1), NTAN1(1), SIRT1(5), SIRT5(1), SIRT7(5), VNN2(1) 14034028 29 28 28 3 4 5 7 6 7 0 0.0224 0.424 1.000 57 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(1), DHRSX(5), PON1(1), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1) 10478074 24 23 19 2 2 1 3 10 8 0 0.181 0.431 1.000 58 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(6), MAPK1(1), MAPK14(2), MAPK3(3), MKNK1(2), PABPC1(17), PDK2(4), PIK3CA(16), PIK3R1(5), PRKCA(3), PTEN(35), RPS6KB1(2) 33193764 127 108 119 21 13 24 13 34 37 6 0.0170 0.436 1.000 59 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(6), IL3(1) 3309864 9 8 9 2 0 2 2 2 3 0 0.526 0.439 1.000 60 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(3), HRAS(1), PTK2B(4), SHC1(4), SOS1(7), SRC(2) 10246089 22 20 22 2 1 7 1 8 5 0 0.0527 0.457 1.000 61 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(1), CD3G(2), CD80(1), CD86(3), CTLA4(1), GRB2(3), HLA-DRA(1), HLA-DRB1(6), ICOS(3), IL2(1), ITK(2), LCK(1), PIK3CA(16), PIK3R1(5), PTPN11(1) 14919257 48 46 41 7 5 13 3 16 11 0 0.0800 0.495 1.000 62 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(3), LEP(1), LEPR(5), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKAG1(6), PRKAG2(7) 17178441 37 36 34 4 2 5 9 9 12 0 0.0154 0.496 1.000 63 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(6), ELOVL6(2), FADS1(1), FADS2(2), FASN(8), HADHA(4), PECR(3) 16829302 38 34 35 4 4 8 4 15 7 0 0.00819 0.501 1.000 64 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL18(1), IL2(1) 3598832 6 6 6 1 0 1 0 3 2 0 0.706 0.504 1.000 65 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(3), MDH1(1), ME1(1), PC(8), PDHA1(1), SLC25A11(4) 10818832 28 27 28 4 2 3 1 13 9 0 0.155 0.517 1.000 66 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(9), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(5), NOS3(3), REN(1) 11439822 26 25 24 3 3 3 3 10 7 0 0.0826 0.522 1.000 67 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 855604 1 1 1 0 0 0 1 0 0 0 0.752 0.528 1.000 68 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3CA(16), PIK3R1(5), RAF1(5), RB1(4), RELA(7) 23847913 65 56 53 8 5 12 7 16 21 4 0.0358 0.557 1.000 69 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(2), BMPR1B(1), BMPR2(6) 7309172 14 12 14 0 0 2 3 6 3 0 0.0140 0.574 1.000 70 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(2) 10223639 19 19 18 2 1 1 2 4 9 2 0.254 0.610 1.000 71 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(6), ENO2(2), ENO3(2), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1) 9835583 25 22 25 4 3 3 5 5 9 0 0.183 0.617 1.000 72 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), APEX1(1), CREBBP(13), DFFA(1), DFFB(1), HMGB2(3), PRF1(1) 12367922 23 22 23 3 4 3 7 4 5 0 0.0449 0.618 1.000 73 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(2), CDC25B(1), CDC25C(4), MNAT1(1), SHH(3), XPO1(7) 10285303 19 19 19 3 2 2 7 6 2 0 0.142 0.638 1.000 74 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(1), MECR(4), PPT1(1) 10002336 18 17 18 2 2 3 5 7 1 0 0.0854 0.654 1.000 75 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(1), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(2) 10290722 22 22 19 3 1 2 2 4 11 2 0.240 0.655 1.000 76 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAR1A(3), PRKAR2B(4) 17918241 43 41 40 5 4 4 5 16 14 0 0.0392 0.677 1.000 77 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), FOS(1), GRB2(3), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4) 20797857 50 47 49 6 6 4 8 19 13 0 0.0376 0.694 1.000 78 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(4), WEE1(2) 8729131 13 12 13 1 1 2 0 6 3 1 0.226 0.701 1.000 79 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(2), OXCT1(2) 4036194 5 5 5 1 0 1 0 2 2 0 0.588 0.703 1.000 80 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(2), ALDOB(5), TPI1(1) 4573571 9 9 8 4 0 0 2 1 6 0 0.979 0.703 1.000 81 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(5), EGFR(10), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), PTPRB(7), RAF1(5), RASA1(7), SHC1(4), SOS1(7), SPRY1(2), SPRY2(3), SPRY4(10), SRC(2) 29507404 72 63 63 8 6 15 10 19 22 0 0.00691 0.707 1.000 82 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(6), CASP8(1), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 9529683 17 17 17 3 0 4 5 6 2 0 0.270 0.714 1.000 83 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(6), GPI(3), HK1(7), PFKL(3), PGK1(3), PKLR(1), TPI1(1) 10653480 29 28 26 5 5 3 2 6 13 0 0.212 0.715 1.000 84 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD4(10), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1) 13179950 35 32 29 5 1 4 3 12 14 1 0.380 0.720 1.000 85 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), FPGS(4), GGH(3) 7426369 23 21 23 6 4 5 3 7 4 0 0.269 0.721 1.000 86 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS1(2), SPCS3(1) 3645746 5 5 5 1 0 0 1 2 2 0 0.669 0.729 1.000 87 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(7), ZAP70(1) 10388157 31 29 25 5 1 4 2 11 12 1 0.499 0.740 1.000 88 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1) 12471261 26 24 26 4 1 4 3 11 7 0 0.255 0.745 1.000 89 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(2), GOT1(3), GOT2(3), LDHB(1), LDHC(3), MPST(2) 7991957 20 20 18 4 1 0 2 6 11 0 0.710 0.745 1.000 90 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CCL2(1), LDLR(4), LPL(6) 6181145 12 12 12 3 1 3 0 4 4 0 0.474 0.749 1.000 91 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(1) 1923861 2 2 2 1 0 0 1 1 0 0 0.874 0.754 1.000 92 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(1), CCNE1(1), CCNE2(4), CDK2(2), CDK4(7), CDKN1B(1), CDKN2A(4), E2F1(1), E2F2(1), PRB1(6) 10411345 35 28 23 7 0 3 4 3 25 0 0.605 0.755 1.000 93 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(23), ATR(11), BRCA1(8), CDC25A(2), CDC25B(1), CDC25C(4), CDKN1A(3), CHEK1(1), CHEK2(3), EP300(16), MYT1(9), PRKDC(10), RPS6KA1(7), TP53(50), WEE1(2) 50594176 150 119 133 22 9 22 16 48 49 6 0.00274 0.755 1.000 94 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 1942941 2 2 2 0 0 0 0 2 0 0 0.702 0.764 1.000 95 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(3), ITGAL(6), ITGAM(9), ITGB2(2), SELE(5), SELL(2) 12488509 30 30 30 5 0 9 5 9 7 0 0.0961 0.766 1.000 96 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(5), PPP1R1B(1) 4332827 7 7 7 2 1 1 1 3 1 0 0.596 0.774 1.000 97 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(3), TIMP1(1), TIMP2(1), TIMP3(4) 8871265 18 17 15 3 2 2 1 6 7 0 0.484 0.776 1.000 98 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(3) 4537325 5 5 5 1 0 0 3 1 1 0 0.588 0.779 1.000 99 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(6), JAK2(7), STAT1(6) 9770238 26 26 26 5 3 0 3 11 9 0 0.495 0.785 1.000 100 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(10), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(1) 6093775 21 20 15 5 0 4 3 3 10 1 0.800 0.803 1.000 101 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(2), GREB1(18), HSPB2(3), MTA1(7), MTA3(4), PDZK1(1), TUBA8(1) 12679545 38 35 36 8 1 5 9 15 8 0 0.355 0.803 1.000 102 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(6), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5) 6209152 15 15 15 4 2 2 1 6 3 1 0.585 0.811 1.000 103 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(1), HMGB1(2), HMGB2(3), TOP2A(5), TOP2B(3) 11885764 16 15 16 1 3 2 2 3 5 1 0.116 0.814 1.000 104 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE3A(4) 12356359 18 18 18 2 2 2 2 8 4 0 0.159 0.822 1.000 105 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDK2(2), CUL1(5), E2F1(1), FBXW7(5), RB1(4) 9994649 18 18 18 3 1 1 3 3 8 2 0.423 0.831 1.000 106 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(8), POLG(6), PRPS2(4), RRM1(4) 14678780 30 29 28 4 2 5 2 10 11 0 0.118 0.836 1.000 107 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(4), GBA(2), GGT1(4), SHMT1(4), SHMT2(6) 6529229 20 20 17 5 2 1 3 5 9 0 0.493 0.857 1.000 108 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 2655701 3 3 3 1 0 0 1 0 2 0 0.902 0.866 1.000 109 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 2388047 2 2 2 1 0 0 0 1 1 0 0.774 0.872 1.000 110 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(5), GNB1(3), PRKACA(1), PRKAR1A(3) 7532310 14 14 14 3 1 1 1 10 1 0 0.646 0.878 1.000 111 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SLC2A4(3), SOS1(7) 29475076 74 69 66 11 10 20 8 24 12 0 0.00801 0.887 1.000 112 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(4), ATM(23), ATR(11), BAI1(4), BAX(1), BID(2), CASP8(1), CASP9(2), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CD82(3), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), FAS(2), GADD45B(2), GTSE1(4), IGFBP3(1), PERP(1), PPM1D(2), PTEN(35), RCHY1(3), RFWD2(4), RRM2(1), SERPINB5(4), SESN1(3), SFN(1), STEAP3(2), THBS1(16), TNFRSF10B(1), TP53(50), TP53I3(4), TP73(4), TSC2(14), ZMAT3(1) 76509917 246 185 228 34 21 32 32 58 93 10 2.63e-05 0.889 1.000 113 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(2) 2459780 7 7 7 3 0 2 1 2 2 0 0.875 0.890 1.000 114 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(2), FUT2(1), GCNT2(5), ST8SIA1(2) 7006778 10 10 10 2 2 1 1 5 1 0 0.352 0.891 1.000 115 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(10), CD8A(1), IL2(1), IL3(1), IL4(1), IL9(1) 7132019 15 15 9 3 0 2 2 2 8 1 0.786 0.894 1.000 116 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(1), NFKB1(1), NOX1(7), RELA(7), TNF(1), XDH(7) 11669608 26 23 21 4 1 2 6 4 12 1 0.490 0.903 1.000 117 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(7), AMT(1), ATIC(3), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6) 21171181 41 40 41 6 4 7 5 16 9 0 0.0473 0.910 1.000 118 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(7), BECN1(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNG(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(2), PRKAA2(4), ULK1(2), ULK2(3), ULK3(4) 24987471 52 49 49 7 4 3 4 27 14 0 0.0919 0.912 1.000 119 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), FDXR(3), SHMT1(4) 18945268 42 40 42 7 3 3 11 15 9 1 0.153 0.912 1.000 120 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADHA(4), PLOD1(3), PLOD2(7), PLOD3(12), SHMT1(4), SHMT2(6), TMLHE(1) 42557587 109 91 97 16 10 17 16 31 34 1 0.00631 0.912 1.000 121 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(3), ACADS(3), ACSL1(2), ACSL3(13), ACSL4(1), CPT1A(3), CPT2(2), EHHADH(6), HADHA(4), PECR(3), SCP2(3) 19867739 46 42 34 8 2 9 10 20 5 0 0.0380 0.913 1.000 122 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(3), GAD1(2), GAD2(3), GGT1(4) 6718975 14 14 14 4 1 1 5 3 4 0 0.506 0.916 1.000 123 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(5), ACSS1(3), ACSS2(8), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SUCLA2(2) 15749565 40 33 36 7 2 6 3 11 17 1 0.229 0.917 1.000 124 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), KERA(2), LUM(1) 4205580 9 9 9 3 0 1 0 5 3 0 0.674 0.920 1.000 125 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(3), JAK1(6), JAK2(7), PTPRU(6), STAT1(6) 13450707 32 30 32 6 4 0 3 17 8 0 0.435 0.924 1.000 126 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(3), MTMR6(1), NFS1(1), PHPT1(1), THTPA(1), TPK1(1) 7567533 10 10 10 2 1 1 2 6 0 0 0.431 0.929 1.000 127 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2) 10577915 20 19 17 4 1 3 1 6 9 0 0.404 0.935 1.000 128 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM7(5), GRM8(3) 23436178 55 48 52 9 7 8 6 23 11 0 0.0741 0.941 1.000 129 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), HMGCS1(4), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1) 15535886 23 21 23 2 0 3 3 10 7 0 0.0972 0.941 1.000 130 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(5), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4) 20706338 48 44 48 9 3 7 12 12 14 0 0.176 0.942 1.000 131 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(10), ERBB3(7), NRG1(4), UBE2D1(2) 12128567 28 28 26 5 4 2 3 9 10 0 0.258 0.942 1.000 132 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1) 10015588 18 18 16 4 2 2 3 4 7 0 0.542 0.943 1.000 133 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH1(1), BDH2(1), HMGCL(2), HMGCS1(4), HMGCS2(3), OXCT1(2) 8734560 14 14 14 3 0 2 1 6 5 0 0.542 0.943 1.000 134 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(1), CNR2(3), DNMT1(23), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), TBXA2R(4) 12598356 43 40 28 9 2 4 6 10 21 0 0.620 0.945 1.000 135 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(4), F2R(2), F5(11), F7(1), FGA(4), FGB(3), FGG(6), PROC(3), PROS1(5), TFPI(1) 19277211 41 39 39 7 6 3 3 14 14 1 0.168 0.946 1.000 136 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB11(4), ABCB4(7), ABCC1(11), ABCC3(10) 17163435 38 32 32 6 2 7 7 10 12 0 0.117 0.946 1.000 137 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), PC(8), PCK1(9), SDHA(8), SDHB(1), SUCLA2(2), SUCLG1(6), SUCLG2(2) 24274091 64 58 61 12 3 9 9 21 21 1 0.132 0.947 1.000 138 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(11), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 14986154 33 32 33 6 8 3 5 10 7 0 0.0967 0.948 1.000 139 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1) 11899140 19 17 19 3 2 3 3 5 6 0 0.251 0.949 1.000 140 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(2), STX1A(1), VAMP2(1) 3774022 6 5 6 3 0 1 0 2 3 0 0.920 0.954 1.000 141 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 142 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 143 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 144 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST8SIA1(2) 12352485 21 20 21 4 3 3 2 10 3 0 0.211 0.958 1.000 145 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(3), DPM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), MAPK3(3), NGFR(2), PIK3CA(16), PIK3R1(5), PLCG1(3), RAF1(5), SHC1(4), SOS1(7) 22157102 58 55 51 10 7 16 6 21 8 0 0.0527 0.961 1.000 146 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(1), CES1(8), ESD(1) 6899681 15 15 13 4 0 3 2 5 5 0 0.502 0.961 1.000 147 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(2), CHUK(2), GHR(1), NFKB1(1), NFKBIA(1), PIK3CA(16), PIK3R1(5), PPP2CA(1), RELA(7) 16942499 37 36 28 6 2 13 1 10 10 1 0.112 0.961 1.000 148 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(2), CBS(1), CTH(2), MUT(2) 5726813 7 7 7 2 1 0 1 1 4 0 0.842 0.961 1.000 149 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), SELE(5), SELL(2), SELP(2) 19016965 41 39 41 8 0 11 8 12 10 0 0.138 0.963 1.000 150 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(6), ATM(23), BRCA1(8), CDKN1A(3), CHEK1(1), CHEK2(3), JUN(2), MRE11A(4), NFKB1(1), NFKBIA(1), RAD50(4), RAD51(2), RBBP8(2), RELA(7), TP53(50), TP73(4) 34843173 121 100 108 21 9 16 12 41 37 6 0.0442 0.965 1.000 151 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(3), EXTL1(2), EXTL2(7), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), NDST1(3), NDST2(4), NDST4(9) 24147806 52 48 46 7 5 9 4 14 20 0 0.0371 0.966 1.000 152 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELE(5), SELL(2) 14368468 30 29 30 6 0 9 6 7 8 0 0.197 0.966 1.000 153 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(4), ATM(23), BAX(1), BID(2), CASP6(1), CASP7(1), CASP9(2), PRKCA(3), PTK2(3), PXN(3), STAT1(6), TLN1(12), TP53(50) 32301423 112 91 102 20 9 13 10 35 41 4 0.0384 0.967 1.000 154 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(3), HSD17B1(2), HSD17B2(1), HSD17B4(1), HSD3B1(1) 9508316 10 10 10 2 2 3 2 2 1 0 0.328 0.967 1.000 155 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(2) 5140988 6 6 6 2 1 0 0 2 3 0 0.849 0.968 1.000 156 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), CDC42(1), WASF1(1), WASL(9) 9604780 24 24 18 5 1 4 2 8 9 0 0.346 0.970 1.000 157 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(3), UGDH(1), UXS1(1) 4707481 5 5 5 2 0 1 3 1 0 0 0.717 0.970 1.000 158 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), JUN(2), KEAP1(4), MAPK1(1), MAPK14(2), NFE2L2(13), PRKCA(3) 10367017 27 27 24 7 2 3 3 14 5 0 0.473 0.971 1.000 159 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(2), ELK1(2), FOS(1), GAB1(1), GRB2(3), HGF(2), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(3), MET(28), PAK1(4), PIK3CA(16), PIK3R1(5), PTEN(35), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAF1(5), RAP1A(1), RASA1(7), SOS1(7), SRC(2), STAT3(4) 52980361 162 130 145 28 10 36 18 45 49 4 0.0114 0.972 1.000 160 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(11), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7) 18530781 41 38 41 8 3 6 3 17 12 0 0.352 0.974 1.000 161 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(2), ENPP1(2), ENPP3(2), FLAD1(5), TYR(5) 11396461 19 19 19 4 0 4 0 10 5 0 0.539 0.975 1.000 162 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(3) 4531700 5 5 5 2 0 0 2 2 1 0 0.810 0.975 1.000 163 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(1), CTH(2), GGT1(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1) 14397996 30 29 30 6 3 3 7 8 9 0 0.300 0.976 1.000 164 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(11), NRG2(3), NRG3(5), PRKCA(3), PSEN1(1) 10732996 26 26 26 6 2 5 3 11 5 0 0.398 0.976 1.000 165 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(4), LDLR(4), MBTPS1(4), MBTPS2(2), SCAP(3), SREBF1(4), SREBF2(11) 13962967 32 32 32 7 3 4 6 8 11 0 0.336 0.977 1.000 166 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(5), ARHGDIB(1), CASP1(2), CASP10(3), CASP8(1), CASP9(2), JUN(2), PRF1(1) 14949157 21 20 21 3 0 4 1 7 9 0 0.367 0.977 1.000 167 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(2), CDC25B(1), CDC25C(4), CSK(4), GRB2(3), PRKCA(3), PTPRA(5), SRC(2) 10889531 24 22 24 5 1 7 4 8 4 0 0.228 0.977 1.000 168 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(3), UGDH(1), UGP2(1), UXS1(1) 5951897 6 6 6 2 0 1 4 1 0 0 0.603 0.978 1.000 169 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), VKORC1(1) 13028401 16 16 16 2 0 1 3 7 5 0 0.258 0.978 1.000 170 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(3), FGG(6), PLAT(4), PLG(6) 15878389 38 35 33 8 6 2 5 14 11 0 0.275 0.978 1.000 171 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(1), GLI2(4), GLI3(7), GSK3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SHH(3), SMO(5), SUFU(3) 18844457 42 40 40 8 5 6 5 15 11 0 0.154 0.979 1.000 172 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(6), CREB1(1), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(2), EIF4E(2), GRB2(3), MAP2K2(1), MAP3K8(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), RPS6KA3(2), SHC1(4), SOS1(7), SOS2(7), TRAF3(1) 34868707 65 62 60 9 7 10 11 21 14 2 0.0211 0.979 1.000 173 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(3), FH(2), IDH2(6), MDH1(1), OGDH(8), SDHA(8), SUCLA2(2) 11153169 30 27 27 7 1 8 0 11 10 0 0.411 0.980 1.000 174 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(4), BAX(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(2), JUN(2), MAP3K1(8), MAPK10(2), MCL1(1), MYC(1), NFKB1(1), NFKBIA(1), PARP1(6), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1) 43916675 124 101 109 22 5 18 16 40 40 5 0.0251 0.980 1.000 175 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(3), EPX(2), LPO(2), MPO(5), MTHFR(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4) 13574663 31 30 31 6 1 3 7 11 9 0 0.297 0.982 1.000 176 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(1), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(1), NOS3(3), NPPA(1), NR3C1(4), PIK3CA(16), PIK3R1(5), RELA(7), SYT1(1) 20939722 51 48 42 9 5 15 2 16 12 1 0.170 0.982 1.000 177 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(3), ITPKA(1), ITPKB(3) 6806857 9 8 9 4 1 1 2 0 5 0 0.915 0.983 1.000 178 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(7), IL3(1), IL9(1), KITLG(2), TGFB2(2) 9890437 14 14 14 3 0 1 3 5 5 0 0.623 0.984 1.000 179 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(5), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(2) 7827104 14 14 12 4 2 2 1 3 6 0 0.723 0.984 1.000 180 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CHEK1(1), MYT1(9), WEE1(2) 16378588 42 38 41 9 3 10 5 14 10 0 0.228 0.984 1.000 181 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYC(3), RB1(4), SP1(2), SP3(3) 7958528 15 15 15 5 0 3 1 4 5 2 0.843 0.984 1.000 182 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4) 14332042 29 29 26 6 3 4 7 8 7 0 0.239 0.985 1.000 183 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(2), ACP6(1), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CMBL(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), DHRSX(5), PON1(1), PON2(2), PON3(5) 21016279 44 42 39 8 4 7 3 14 16 0 0.263 0.985 1.000 184 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(7), AMT(1), ATIC(3), FTCD(3), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6) 22501622 45 44 45 9 4 7 5 20 9 0 0.180 0.985 1.000 185 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(2), HDC(1), TH(4), TPH1(3) 6893106 12 12 12 4 2 2 4 2 2 0 0.633 0.985 1.000 186 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(3), PAPSS1(3), PAPSS2(4), SULT2A1(1), SUOX(5) 8504618 16 15 16 4 1 1 4 3 7 0 0.601 0.986 1.000 187 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(7), C6(3), C7(4), C8A(3), C9(1) 15081835 27 27 27 5 2 5 3 13 4 0 0.219 0.986 1.000 188 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1), MASP1(5), MASP2(2), MBL2(2) 32887906 63 54 48 8 6 10 5 26 15 1 0.0136 0.986 1.000 189 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(3), EPHB1(3), FYN(2), ITGA1(8), ITGB1(6), L1CAM(5), LYN(3), SELP(2) 18462940 33 31 32 5 4 4 2 13 10 0 0.164 0.987 1.000 190 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), IDS(2), IDUA(2), LCT(5), NAGLU(3) 16997409 38 33 38 8 4 6 5 11 12 0 0.199 0.987 1.000 191 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(1), HSD3B1(1) 7999811 10 10 10 3 1 0 1 7 1 0 0.614 0.987 1.000 192 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), E2F1(1), RB1(4) 18790173 37 33 31 9 2 1 4 7 20 3 0.623 0.987 1.000 193 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(5), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HMGCR(1), IDI1(1), IDI2(2), LSS(4), MVK(1), NSDHL(3), PMVK(1), TM7SF2(3), VKORC1(1) 22729691 33 31 31 3 1 3 2 15 12 0 0.0856 0.988 1.000 194 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(6), NR3C1(4), PPARG(3), RETN(1), RXRA(2), TNF(1) 6617286 18 17 18 6 2 6 1 3 6 0 0.637 0.988 1.000 195 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RELA(7) 9734433 15 15 12 7 1 3 0 1 9 1 0.978 0.988 1.000 196 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1) 3860292 4 4 4 2 0 0 0 2 2 0 0.955 0.989 1.000 197 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15B(4), ALOX5(4), DPEP1(2), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 17900650 41 37 39 8 5 5 8 11 11 1 0.200 0.989 1.000 198 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1) 8292640 21 21 21 6 0 1 3 10 7 0 0.720 0.990 1.000 199 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(4), NFATC2(6), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 13579389 34 32 32 8 6 1 3 13 11 0 0.398 0.991 1.000 200 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), IFNG(2), IL2(1), IL2RA(2), IL4(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), TOB1(4), TOB2(3) 12598947 24 24 24 5 1 2 6 8 7 0 0.352 0.991 1.000 201 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1) 27630715 58 53 56 9 4 9 5 22 18 0 0.0652 0.992 1.000 202 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3) 17396623 28 25 24 3 1 2 6 8 11 0 0.189 0.992 1.000 203 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C8B(2), C9(1), MASP1(5) 32216097 61 52 46 8 7 9 4 25 15 1 0.0201 0.993 1.000 204 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(3), EPX(2), LPO(2), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4) 13835971 32 31 32 7 1 4 7 11 9 0 0.346 0.993 1.000 205 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1) 28320458 54 45 39 7 4 8 4 23 14 1 0.0327 0.993 1.000 206 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(3) 5762026 6 6 6 2 0 1 0 1 4 0 0.914 0.994 1.000 207 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(4) 15582305 28 28 28 5 1 2 3 14 8 0 0.440 0.994 1.000 208 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1) 10116055 16 16 16 4 0 1 1 9 5 0 0.798 0.994 1.000 209 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT3(2), FUT5(1), FUT6(4), ST3GAL3(3) 5583180 11 10 9 4 4 2 0 2 3 0 0.708 0.994 1.000 210 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(10), HRAS(1), MAP2K2(1), MAPK1(1), MAPK3(3), NGFR(2), RAF1(5) 9540427 24 24 17 6 4 1 2 8 9 0 0.702 0.994 1.000 211 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNB1(2), JAK1(6), STAT1(6), STAT2(7), TYK2(7) 12734329 32 27 31 8 4 5 4 7 12 0 0.328 0.995 1.000 212 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(2), NFKB1(1), RELA(7), TNFRSF13B(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2) 17056100 22 21 19 3 0 5 0 7 9 1 0.368 0.995 1.000 213 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5) 15575333 34 33 32 7 2 4 6 9 13 0 0.331 0.996 1.000 214 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(20), MAP2(5), PPP2CA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4), PRKCE(4) 21093846 45 41 42 8 5 4 4 16 15 1 0.179 0.996 1.000 215 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(10), ELK1(2), GNAS(5), GNB1(3), GRB2(3), HRAS(1), IGF1R(4), ITGB1(6), MAP2K2(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MYC(1), NGFR(2), PDGFRA(6), PPP2CA(1), PTPRR(6), RAF1(5), RPS6KA1(7), RPS6KA5(3), SHC1(4), SOS1(7), SRC(2), STAT3(4) 38822999 92 79 86 16 10 19 8 31 23 1 0.0447 0.996 1.000 216 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3) 6673482 11 11 10 5 1 0 0 7 3 0 0.931 0.996 1.000 217 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADSYN1(1), NMNAT2(3), NNMT(1), NNT(9), NT5C(1), NT5M(3), QPRT(1) 17203425 32 32 32 7 3 4 3 17 5 0 0.330 0.996 1.000 218 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(3), EPOR(1), GRIN1(2), HIF1A(5), JAK2(7), NFKB1(1), NFKBIA(1), RELA(7) 14984819 29 27 26 6 0 4 4 8 10 3 0.519 0.996 1.000 219 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(2), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), TPO(4), TYR(5) 11339263 23 22 23 5 0 3 5 8 7 0 0.439 0.996 1.000 220 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(1), CAT(3), GHR(1), HRAS(1), IGF1R(4), PIK3CA(16), PIK3R1(5), SHC1(4) 15346092 35 32 29 8 4 10 2 13 6 0 0.277 0.996 1.000 221 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12) 19491005 38 35 36 5 3 3 2 14 16 0 0.158 0.996 1.000 222 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(4), SNCAIP(5), UBE2E2(1), UBE2L3(1) 7467277 16 16 16 5 1 4 2 6 3 0 0.588 0.996 1.000 223 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(1), AKT2(4), AKT3(2), GRB2(3), GSK3A(1), GSK3B(3), IL4R(5), IRS1(6), JAK1(6), JAK3(4), MAP4K1(3), MAPK1(1), MAPK3(3), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PPP1R13B(6), RAF1(5), SHC1(4), SOCS1(1), SOS1(7), SOS2(7), STAT6(4) 41404962 100 88 92 16 13 20 15 34 18 0 0.00391 0.997 1.000 224 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(3), IL10RA(3), IL10RB(1), JAK1(6), STAT1(6), STAT3(4), STAT5A(4), TNF(1) 14310346 29 29 28 6 4 1 1 11 12 0 0.686 0.997 1.000 225 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(2), JAK1(6), PTPRU(6), STAT1(6), STAT2(7), TYK2(7) 14548500 37 32 36 9 5 4 4 12 12 0 0.317 0.997 1.000 226 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(11), AXIN1(5), BTRC(4), CTNNB1(4), DLL1(1), DVL1(1), FZD1(2), GSK3B(3), NOTCH1(9), PSEN1(1), WNT1(2) 24213001 46 44 43 7 4 5 3 22 11 1 0.108 0.997 1.000 227 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 9064046 17 16 16 8 1 0 2 5 9 0 0.984 0.997 1.000 228 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(3), IL4(1), IL4R(5), IRS1(6), JAK1(6), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(4) 16903039 36 34 36 8 6 3 6 12 9 0 0.306 0.997 1.000 229 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), EIF4E(2), IFNG(2), IFRD1(1), IL18(1), IL1R1(3), NR4A3(2), WDR1(1) 12784417 17 17 17 4 1 3 3 5 5 0 0.502 0.997 1.000 230 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(2), AKT1(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(5), GRB2(3), HRAS(1), MAPK1(1), MAPK14(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RPS6KA1(7), RPS6KA5(3), SOS1(7) 34198224 80 75 70 13 9 19 5 30 16 1 0.0290 0.997 1.000 231 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(6), FYN(2), LRP8(6), RELN(8), VLDLR(3) 16515271 25 24 20 4 1 5 1 7 11 0 0.525 0.998 1.000 232 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(2), CAD(13), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GLS(9), GLS2(4), GLUD1(1), GLUL(2), GMPS(1), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(4) 39226451 76 68 72 10 4 7 15 27 22 1 0.0280 0.998 1.000 233 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(3), CHST11(1), CHST12(2), CHST13(1), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT2A1(1), SUOX(5) 11817656 22 21 21 5 3 2 5 3 9 0 0.523 0.998 1.000 234 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA1(4), ACADM(3), ACADS(3), ACAT1(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(1), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4) 51355767 94 90 90 12 7 9 19 35 23 1 0.00473 0.998 1.000 235 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7) 12218455 27 26 26 9 3 0 6 8 10 0 0.829 0.998 1.000 236 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7) 12218455 27 26 26 9 3 0 6 8 10 0 0.829 0.998 1.000 237 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 19004529 39 36 39 8 3 8 2 16 10 0 0.153 0.998 1.000 238 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), PANK1(4), PANK2(5), PANK3(2), PANK4(1), UPB1(2) 16311597 29 28 29 7 3 3 5 9 9 0 0.379 0.999 1.000 239 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(2), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), FN3K(1), GCDH(5), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 30406528 41 39 34 4 2 7 6 8 18 0 0.0677 0.999 1.000 240 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2), COQ6(1), COQ7(1), NDUFA13(2) 4897379 7 7 7 4 3 1 0 2 1 0 0.864 0.999 1.000 241 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4) 42709538 83 80 79 13 6 10 18 30 19 0 0.0236 0.999 1.000 242 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 15129445 28 28 28 7 4 3 3 14 4 0 0.414 0.999 1.000 243 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(5), CALCRL(3), CD97(7), CRHR1(2), CRHR2(4), ELTD1(4), EMR1(2), EMR2(3), GIPR(2), GLP1R(3), GLP2R(5), GPR64(2), LPHN1(6), LPHN2(4), LPHN3(11), SCTR(1), VIPR1(1), VIPR2(1) 32308051 68 61 66 12 10 8 11 26 12 1 0.0301 0.999 1.000 244 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(4), NR1H3(2), NR1H4(2), RXRA(2) 6175692 10 10 10 4 0 4 0 3 3 0 0.724 0.999 1.000 245 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(5), CLYBL(3), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), OGDHL(3), PC(8), PCK1(9), PCK2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 35143242 92 79 89 18 6 14 10 32 29 1 0.100 0.999 1.000 246 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 15869680 28 28 28 7 4 3 3 14 4 0 0.414 0.999 1.000 247 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(3), HTR2C(1), PLCB1(3), TUB(3) 8368268 12 11 12 4 1 2 0 7 2 0 0.696 0.999 1.000 248 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1) 26459766 68 60 62 13 5 8 8 27 19 1 0.243 0.999 1.000 249 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1) 26459766 68 60 62 13 5 8 8 27 19 1 0.243 0.999 1.000 250 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(6), CREB1(1), CREB5(3), MAPK1(1), RAF1(5), SNX13(3), SRC(2), TERF2IP(1) 13595024 26 22 25 6 1 6 4 9 5 1 0.359 0.999 1.000 251 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(5), GNB1(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3) 11260408 25 24 25 6 3 3 1 12 6 0 0.567 0.999 1.000 252 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(3), SULT1C4(5), SULT4A1(1) 14776777 33 33 31 9 2 2 5 10 14 0 0.812 0.999 1.000 253 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(5), AOC3(1), CES1(8), DDHD1(3), ESCO1(4), ESCO2(1), LIPA(1), PLA1A(4), PNPLA3(3), PRDX6(2), SH3GLB1(3) 29648540 36 34 34 3 1 6 3 12 14 0 0.0413 0.999 1.000 254 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(9), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2) 15603561 27 25 25 5 2 7 4 6 8 0 0.257 0.999 1.000 255 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(3), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1), YARS2(1) 10272578 19 18 19 5 2 2 3 5 7 0 0.686 0.999 1.000 256 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(3), GNE(2), GNPDA1(1), GNPNAT1(2), HEXA(5), HEXB(1), HK1(7), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), NPL(6), PHPT1(1), RENBP(5), UAP1(1) 33858755 68 64 65 10 7 7 12 24 17 1 0.0122 0.999 1.000 257 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(1), AGT(4), AKT1(1), CALM2(1), CALR(2), CAMK1(3), CAMK1G(4), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(2), F2(4), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), LIF(1), MAPK1(1), MAPK14(2), MAPK3(3), MEF2C(1), MYH2(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKX2-5(1), NPPA(1), PIK3CA(16), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAF1(5), RPS6KB1(2), SYT1(1) 58954663 134 114 123 22 17 19 15 42 41 0 0.00453 0.999 1.000 258 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(5), PPP2CA(1) 11058258 14 14 12 7 0 1 2 2 9 0 0.957 0.999 1.000 259 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(2), ADSL(2), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), CAD(13), CRAT(2), DARS(4), DDO(1), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), PC(8) 30610344 63 56 59 10 1 8 11 15 27 1 0.127 0.999 1.000 260 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4) 11829678 23 23 23 6 3 3 5 8 4 0 0.397 0.999 1.000 261 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(3), BIRC3(6), CASP10(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(3), SREBF1(4), SREBF2(11) 21330582 41 39 41 8 2 7 6 13 13 0 0.189 1.000 1.000 262 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(2), ACP6(1), ENPP1(2), ENPP3(2), FLAD1(5), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5) 17715684 27 26 27 5 0 5 1 16 5 0 0.378 1.000 1.000 263 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT2(1), FUT3(2), ST3GAL3(3), ST3GAL4(2) 8269899 15 14 13 6 5 0 2 2 6 0 0.846 1.000 1.000 264 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(6), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(6), SOAT1(5) 16243447 38 33 36 9 2 2 8 15 11 0 0.427 1.000 1.000 265 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(5), AKT1(1), AKT2(4), AKT3(2), APAF1(4), ATM(23), BAX(1), BID(2), BIRC2(3), BIRC3(6), CAPN1(2), CAPN2(3), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), CSF2RB(7), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(6), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1) 98950314 252 192 227 32 23 38 31 88 67 5 6.55e-07 1.000 1.000 266 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CASP9(2), CDC42(1), CHUK(2), ELK1(2), HRAS(1), MAPK3(3), NFKB1(1), PIK3CA(16), PIK3R1(5), RAF1(5), RALA(3), RALBP1(3), RELA(7) 22631222 52 50 42 10 4 16 3 15 13 1 0.153 1.000 1.000 267 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(7), KHK(5), LCT(5), MPI(2), PGM1(1), PYGL(1), PYGM(4), TPI1(1) 15986360 26 25 26 6 5 2 4 9 6 0 0.308 1.000 1.000 268 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ACADM(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2) 31520225 63 59 60 12 4 7 15 17 19 1 0.0753 1.000 1.000 269 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(1), GPR171(1), GPR18(2), GPR34(1), GPR39(2), GPR45(3), GPR65(5), GPR75(1) 11457683 17 17 17 5 3 3 0 8 2 1 0.410 1.000 1.000 270 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(2), IFNG(2), IKBKB(3), IL2(1), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TNFRSF9(1), TNFSF9(1), TRAF2(1) 23191235 45 38 42 8 1 4 1 19 19 1 0.528 1.000 1.000 271 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(4), AKT3(2), BCR(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), PDK1(1), PIK3CA(16), PITX2(2), PLCG2(3), PPP1R13B(6), PREX1(9), PTEN(35), PTPRC(7), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SAG(5), SYK(2), TEC(5), VAV1(6) 65169708 161 139 151 27 11 27 18 48 52 5 0.00496 1.000 1.000 272 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(4) 7893439 12 12 11 6 1 3 1 2 5 0 0.932 1.000 1.000 273 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NFKB1(1), PIK3CA(16), PIK3R1(5), RB1(4), RELA(7), SP1(2) 23167264 55 50 46 10 4 13 2 18 15 3 0.207 1.000 1.000 274 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SOS1(7) 28625372 70 65 64 14 10 20 6 23 11 0 0.0528 1.000 1.000 275 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), PER1(8) 9954612 18 18 17 5 2 0 3 7 6 0 0.650 1.000 1.000 276 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(1), AKT2(4), AKT3(2), BRD4(6), CBL(2), CDC42(1), CDKN2A(4), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), LNPEP(4), MAPK1(1), MAPK3(3), PARD3(7), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PTEN(35), PTPN1(2), RAF1(5), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(2), SOS1(7), SOS2(7), YWHAB(1) 67581897 160 138 146 27 15 22 22 44 52 5 0.00973 1.000 1.000 277 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(5), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3) 19334188 17 17 13 1 0 3 2 4 8 0 0.212 1.000 1.000 278 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(5), PLCE1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAP2B(2) 17159196 28 28 28 6 3 4 3 10 8 0 0.398 1.000 1.000 279 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), RPE(2), RPIA(3), TKT(3), TPI1(1) 21056188 40 37 39 9 2 7 6 7 18 0 0.444 1.000 1.000 280 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(2), CDC25C(4), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), MYT1(9), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RPS6KA1(7), SRC(2) 23830780 53 48 49 10 6 11 4 21 10 1 0.119 1.000 1.000 281 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(11), ABCC2(5), ABCG2(1), BCHE(2), CES1(8), CES2(2), CYP3A5(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6) 27159877 60 52 55 13 4 7 13 17 19 0 0.327 1.000 1.000 282 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR7(1), CD28(1), CD4(10), CXCR4(1), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18R1(1), IL2(1), IL4(1), IL4R(5), TGFB2(2) 23613749 41 40 35 8 5 2 5 13 15 1 0.371 1.000 1.000 283 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1) 10602345 15 15 15 7 1 0 2 7 5 0 0.800 1.000 1.000 284 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1) 10602345 15 15 15 7 1 0 2 7 5 0 0.800 1.000 1.000 285 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(4), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(4), CHST4(1), CHST6(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 13759447 29 26 28 9 2 4 2 6 15 0 0.861 1.000 1.000 286 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), LPO(2), MPO(5), PRDX6(2), TPO(4) 9788037 17 16 17 5 0 2 4 5 6 0 0.633 1.000 1.000 287 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(5), ABAT(2), ACY3(1), ADSL(2), ADSSL1(3), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), ASRGL1(4), ASS1(2), CAD(13), CRAT(2), DARS(4), DARS2(1), DDO(1), DLAT(3), DLD(4), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1) 44493678 97 79 90 15 5 12 14 27 37 2 0.0377 1.000 1.000 288 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(3), IFNB1(2), NFKB1(1), RELA(7), TNFRSF11A(2), TRAF6(2) 12774581 18 18 15 6 1 5 1 2 8 1 0.836 1.000 1.000 289 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), NAGLU(3), SPAM1(8) 24277195 59 50 59 13 9 9 8 20 13 0 0.105 1.000 1.000 290 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1R(1), TNF(1) 7202206 4 4 4 2 0 1 0 1 2 0 0.944 1.000 1.000 291 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), MAPK1(1), MAPK3(3), PIK3CA(16), PIK3R1(5), RAF1(5), SHC1(4), SOS1(7) 21871187 56 51 50 12 9 14 4 21 8 0 0.101 1.000 1.000 292 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(4) 8905159 13 13 13 9 1 0 3 6 3 0 0.984 1.000 1.000 293 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(2), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3) 16369350 26 23 26 5 2 2 5 9 8 0 0.418 1.000 1.000 294 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), EGF(5), EGFR(10), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4) 44133369 108 94 98 19 11 22 11 33 31 0 0.0524 1.000 1.000 295 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3) 9366198 16 16 14 5 2 1 3 5 5 0 0.752 1.000 1.000 296 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3) 9366198 16 16 14 5 2 1 3 5 5 0 0.752 1.000 1.000 297 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), NAT1(1), NAT2(1), XDH(7) 9346798 24 24 24 9 4 2 3 10 5 0 0.849 1.000 1.000 298 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(10), HLA-DRA(1), HLA-DRB1(6), IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL2(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TNF(1) 15409241 30 28 24 7 0 6 3 8 12 1 0.678 1.000 1.000 299 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(1), FURIN(3), NOTCH1(9), PSEN1(1) 10180266 17 17 15 5 2 2 0 7 5 1 0.763 1.000 1.000 300 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(8), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF5(4), GSK3B(3) 13614975 25 23 23 7 2 2 6 5 10 0 0.618 1.000 1.000 301 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(11), AXIN1(5), BTRC(4), CREBBP(13), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(4), DVL1(1), FZD1(2), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2) 34392307 71 63 65 13 6 6 10 26 23 0 0.108 1.000 1.000 302 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(1), GFPT1(3), GNE(2), GNPDA1(1), HEXA(5), HEXB(1), HK1(7), RENBP(5), UAP1(1) 20015585 29 27 29 6 3 2 5 11 8 0 0.292 1.000 1.000 303 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(3), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), THPO(1) 35283007 89 80 81 17 8 18 11 30 22 0 0.128 1.000 1.000 304 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(23), ATR(11), BRCA1(8), BRCA2(10), CHEK1(1), CHEK2(3), FANCA(6), FANCD2(1), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(4), RAD17(2), RAD50(4), RAD51(2), TP53(50), TREX1(3) 52242510 137 112 127 23 10 21 16 49 37 4 0.0188 1.000 1.000 305 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2) 6565915 13 12 13 6 3 2 2 5 1 0 0.657 1.000 1.000 306 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(2), EPOR(1), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4) 25323206 53 49 51 10 4 7 10 18 14 0 0.196 1.000 1.000 307 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(4), MUSK(3), PIK3CA(16), PIK3R1(5), PTK2(3), PTK2B(4), SRC(2), TERT(10) 19366274 48 44 42 11 5 18 2 15 8 0 0.106 1.000 1.000 308 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(11), AR(18), ASAH1(2), BRAF(6), DAG1(3), EGFR(10), GNA15(1), GNAI1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(5), SRC(2) 62779531 137 116 120 23 12 26 20 55 23 1 0.00258 1.000 1.000 309 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(4), CASP9(2), DAXX(6), FAS(2), FASLG(2), HSPB2(3), MAPKAPK2(2), TNF(1) 12987058 23 21 23 6 2 5 3 7 6 0 0.479 1.000 1.000 310 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(4), HDAC9(3), MEF2A(2), MEF2C(1), MEF2D(1) 9621659 14 14 13 7 2 1 2 5 4 0 0.880 1.000 1.000 311 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL16(5), IL18(1), IL2(1), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1) 11552356 18 17 18 7 0 4 2 8 4 0 0.834 1.000 1.000 312 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1) 15729931 27 27 24 8 3 1 2 12 9 0 0.765 1.000 1.000 313 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ALDH4A1(2), CAD(13), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS(9), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), GMPS(1), GNPNAT1(2), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSR(2), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(4) 46608090 87 77 83 14 6 7 20 30 23 1 0.0457 1.000 1.000 314 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 36274605 51 48 44 7 3 7 8 12 21 0 0.0949 1.000 1.000 315 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TGFB2(2), TNF(1), TRAF6(2) 34819817 56 50 52 9 6 11 1 18 19 1 0.173 1.000 1.000 316 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST6GALNAC4(1), ST8SIA1(2) 6435518 13 13 13 5 1 3 1 7 1 0 0.581 1.000 1.000 317 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(3), DLAT(3), DLD(4), FH(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PDK1(1), PDK2(4), PDK3(2), PDK4(2), PDP2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 33507876 78 67 75 17 3 13 10 25 26 1 0.183 1.000 1.000 318 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2) 7336486 12 12 12 9 4 3 0 4 1 0 0.908 1.000 1.000 319 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2) 7336486 12 12 12 9 4 3 0 4 1 0 0.908 1.000 1.000 320 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RAF1(5), RELA(7), TNF(1) 17910353 32 31 29 9 6 3 2 8 12 1 0.720 1.000 1.000 321 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(4), AKT3(2), BRAF(6), CAB39(1), DDIT4(1), EIF4B(4), FIGF(2), HIF1A(5), INS(1), MAPK1(1), MAPK3(3), PGF(2), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRKAA1(2), PRKAA2(4), RHEB(4), RICTOR(5), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), STK11(2), TSC1(5), TSC2(14), ULK1(2), ULK2(3), ULK3(4), VEGFA(1), VEGFC(2) 62674763 139 126 120 24 15 20 16 47 35 6 0.0117 1.000 1.000 322 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAX(1), BCL10(2), BCL2L11(1), BID(2), CASP9(2), CES1(8) 13495874 20 20 18 5 0 3 1 8 8 0 0.684 1.000 1.000 323 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CBS(1), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(2) 28969793 54 50 54 10 4 5 14 16 15 0 0.170 1.000 1.000 324 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(5), RPE(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), XYLB(4) 31485702 70 64 70 15 5 9 17 21 18 0 0.203 1.000 1.000 325 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2C1(6), MANBA(2), NEU1(1) 19064206 28 27 28 7 2 4 2 13 7 0 0.404 1.000 1.000 326 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(7) 11072456 20 20 20 6 4 1 4 7 4 0 0.728 1.000 1.000 327 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4) 41149384 99 88 91 18 10 21 9 32 27 0 0.0669 1.000 1.000 328 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(2), CREBBP(13), EP300(16), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2) 26534389 53 48 47 11 2 7 10 10 23 1 0.340 1.000 1.000 329 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), IL2(1), IL2RA(2), IL4(1), IL4R(5) 14751873 35 33 35 10 5 3 3 11 13 0 0.621 1.000 1.000 330 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(3), OTC(1), PYCR1(1), SMS(2) 21038884 33 33 33 8 0 2 6 13 12 0 0.659 1.000 1.000 331 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(7), IMPA1(1), PGM1(1) 12029426 10 9 10 7 2 1 0 3 4 0 0.954 1.000 1.000 332 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2) 11650638 18 18 18 6 1 2 1 10 4 0 0.639 1.000 1.000 333 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ACADL(3), ACADM(3), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2) 33945269 68 64 65 15 4 9 18 18 18 1 0.124 1.000 1.000 334 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP4A11(6), ECHS1(3), EHHADH(6), GCDH(5), HADH(1), HADHA(4), HADHB(4), HSD17B4(1) 57864343 112 95 93 20 8 15 21 43 25 0 0.0212 1.000 1.000 335 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(6), GNAS(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SLC9A3R1(1) 15154538 28 28 28 8 3 3 1 14 7 0 0.736 1.000 1.000 336 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL2(1), IL2RA(2), IL2RB(2), JAK1(6), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4), SYK(2) 27463900 57 54 56 12 7 8 10 18 14 0 0.185 1.000 1.000 337 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5) 12333616 19 19 19 6 3 6 2 6 2 0 0.368 1.000 1.000 338 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), DPM2(1), GRB2(3), HRAS(1), NTRK1(6), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), SHC1(4), SOS1(7) 18221875 50 47 42 12 3 15 3 18 11 0 0.303 1.000 1.000 339 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(1) 23494409 32 30 32 7 3 4 3 15 7 0 0.251 1.000 1.000 340 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1) 8940101 8 7 8 5 1 2 1 3 1 0 0.907 1.000 1.000 341 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), IKBKAP(3), IKBKB(3), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), TNFAIP3(2), TRAF3(1), TRAF6(2) 22031198 30 27 27 6 1 6 0 8 14 1 0.559 1.000 1.000 342 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(9), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 8647515 14 13 14 9 3 0 5 5 1 0 0.954 1.000 1.000 343 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(1), CD3G(2), CD4(10), IFNG(2), IL12RB1(3), IL12RB2(3), JAK2(7), STAT4(2), TYK2(7) 17396389 40 38 33 10 3 1 6 13 16 1 0.836 1.000 1.000 344 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(1), PLCG1(3), PRKCA(3), RELA(7) 23987538 44 40 38 10 5 4 5 13 16 1 0.542 1.000 1.000 345 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(4) 28576177 49 47 46 10 5 8 8 16 12 0 0.138 1.000 1.000 346 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GCNT2(5), ST8SIA1(2) 17993869 33 30 32 9 5 6 4 9 9 0 0.532 1.000 1.000 347 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(11), AXIN1(5), CTNNB1(4), DVL1(1), FZD1(2), GNAI1(3), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(1), PIK3CA(16), PIK3R1(5), PPP2CA(1), RELA(7), TLR4(2), WNT1(2) 35721269 72 68 61 14 5 16 5 26 19 1 0.105 1.000 1.000 348 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(11), ATF2(3), AXIN1(5), BMP10(1), BMP2(1), BMP4(2), BMP5(1), BMP7(5), BMPR1A(2), BMPR2(6), CHRD(5), CTNNB1(4), DVL1(1), FZD1(2), GATA4(2), GSK3B(3), MAP3K7(3), MEF2C(1), MYL2(1), NKX2-5(1), NOG(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), WNT1(2) 42239001 77 66 75 13 9 7 7 33 21 0 0.0471 1.000 1.000 349 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JAK2(7), MAPK1(1), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTPN6(3), RAF1(5), RPS6KA1(7), SHC1(4), SLC2A4(3), SOCS1(1), SOS1(7), STAT5A(4), STAT5B(4) 38746384 92 81 78 19 10 16 11 29 25 1 0.175 1.000 1.000 350 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(7), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(5) 29178988 54 51 54 12 4 8 8 24 10 0 0.234 1.000 1.000 351 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), ATP7A(6), ATP7B(9), COX10(5), COX5A(1), COX7A1(2), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(8), SDHB(1), SHMT1(4), UQCRC1(2), UQCRFS1(2) 45252283 107 94 106 22 7 15 21 40 23 1 0.0819 1.000 1.000 352 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(2), BLNK(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK1(1), MAPK3(3), MAPK8IP3(1), PAPPA(5), RPS6KA1(7), RPS6KA3(2), SHC1(4), SOS1(7), SYK(2), VAV1(6), VAV2(4), VAV3(2) 37319224 70 63 66 13 8 11 7 30 13 1 0.0764 1.000 1.000 353 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), RPE(2), RPIA(3), TKT(3), TKTL1(2), TKTL2(4), TPI1(1) 23560559 44 42 43 10 2 7 6 10 19 0 0.464 1.000 1.000 354 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(7), IMPA1(1), IMPA2(3), PGM1(1) 13618439 13 12 13 9 3 1 0 4 5 0 0.980 1.000 1.000 355 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), HDAC5(3), MEF2A(2), MEF2C(1), MEF2D(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), SLC2A4(3), SYT1(1) 24266643 36 36 35 9 6 3 5 13 9 0 0.350 1.000 1.000 356 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(8), MYL2(1), MYLK(5), NCF2(2), PAK1(4), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLD1(3), PPP1R12B(3), RALBP1(3), RPS6KB1(2), TRIO(8), VAV1(6), WASF1(1) 41295663 83 77 75 16 7 14 7 32 23 0 0.153 1.000 1.000 357 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), TAT(3), TPO(4) 25647748 51 47 48 12 5 6 11 11 18 0 0.348 1.000 1.000 358 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), F2(4), FYN(2), GNAI1(3), GNB1(3), GRB2(3), HRAS(1), JAK2(7), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(3), MAPT(5), MYLK(5), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), SYT1(1) 49429298 95 84 93 17 9 13 11 38 24 0 0.0755 1.000 1.000 359 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(10), CLTA(2), CLTB(2), COPA(7), GBF1(14), GPLD1(2), KDELR3(7) 19261245 48 45 48 12 3 2 6 20 15 2 0.569 1.000 1.000 360 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(2), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(1), PIK3CA(16), PIK3R1(5), RAF1(5), SOS1(7), STAT1(6), STAT5A(4), STAT5B(4) 32620461 76 71 69 16 6 14 8 32 16 0 0.191 1.000 1.000 361 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAX(1), BID(2), BIK(2), BIRC2(3), BIRC3(6), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1) 15962158 25 25 25 7 0 3 4 12 6 0 0.582 1.000 1.000 362 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(6), PIK3CA(16), PIK3R1(5), PLCG1(3), RPS6KA1(7), SHC1(4) 22591278 56 51 44 13 7 11 4 20 13 1 0.265 1.000 1.000 363 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(3), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), GCK(1), IL1R1(3), JUN(2), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK10(2), MAPK7(1), MAPK9(2), NFATC3(8), NR2C2(1), PAPPA(5), SHC1(4), TP53(50), TRAF6(2), ZAK(5) 58729559 151 124 139 29 11 16 17 57 45 5 0.0508 1.000 1.000 364 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), GNMT(1), MAOA(2), MAOB(3), PHGDH(3), PIPOX(3), PISD(1), PSAT1(2), RDH11(4), RDH12(3), RDH13(1), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6), TARS2(5) 50341370 99 91 95 19 11 14 14 31 28 1 0.0437 1.000 1.000 365 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), NT5C(1), NT5M(3), NUDT2(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), UCK1(1), UCK2(1), UMPS(3), UNG(2), UPB1(2), UPP1(3) 67454276 124 102 116 20 8 14 17 35 48 2 0.0236 1.000 1.000 366 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(1), AKT2(4), AKT3(2), CDC42(1), CDK2(2), CDKN1B(1), CDKN2A(4), CREB1(1), CREB5(3), ERBB4(11), F2RL2(2), GAB1(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), MET(28), MYC(1), NOLC1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARD3(7), PDK1(1), PIK3CA(16), PIK3CD(2), PPP1R13B(6), PREX1(9), PTEN(35), PTK2(3), PTPN1(2), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(7), SOS2(7), TSC1(5), TSC2(14), YWHAB(1) 88587512 239 193 215 38 19 39 30 69 74 8 0.000349 1.000 1.000 367 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(23), BMPR1B(1), CCND2(1), CDK4(7), CDKN1B(1), DAZL(1), DMC1(1), EGR1(10), ESR2(5), FSHR(2), GJA4(1), LHCGR(1), MLH1(5), NCOR1(11), NR5A1(1), NRIP1(6), PGR(4), PRLR(3), PTGER2(1), SMPD1(5), VDR(2), ZP2(5) 40354319 97 85 84 21 11 11 9 33 32 1 0.287 1.000 1.000 368 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(11), AXIN1(5), CREBBP(13), CTNNB1(4), DVL1(1), EP300(16), FZD1(2), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(13), WNT1(2) 38598774 79 70 70 17 5 5 12 31 26 0 0.313 1.000 1.000 369 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1B10(2), AKR1C4(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), LIPA(1), RDH11(4), RDH12(3), RDH13(1), SLC27A5(3), SOAT1(5), SOAT2(2), SRD5A1(1) 37421934 68 65 62 14 6 4 6 32 20 0 0.294 1.000 1.000 370 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(13), EP300(16), FYN(2), IL7R(1), JAK1(6), JAK3(4), LCK(1), PIK3CA(16), PIK3R1(5), PTK2B(4), STAT5A(4), STAT5B(4) 33010067 76 69 66 17 5 14 13 21 23 0 0.219 1.000 1.000 371 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), NCK1(1), NCKAP1(2), NTRK1(6), PSMA7(1), WASF1(1), WASF2(2), WASF3(2), WASL(9) 17937292 37 34 30 10 1 5 3 15 13 0 0.529 1.000 1.000 372 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(2), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), HMGCL(2), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1) 30441864 51 50 47 11 7 7 10 14 13 0 0.150 1.000 1.000 373 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLB(2), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(6), POLG2(5), POLH(4), POLI(4), POLK(5), POLL(3), POLM(6), POLQ(12), PRIM1(2), PRIM2(2), REV1(5), REV3L(15), RFC5(2) 48565324 93 79 87 16 5 10 6 44 28 0 0.146 1.000 1.000 374 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX6(1), GSR(2), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), OPLAH(4), TXNDC12(2) 26240822 54 45 51 12 2 4 16 19 13 0 0.246 1.000 1.000 375 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(11), EIF4E(2), FBL(2), GPT(4), LDHB(1), LDHC(3), MAPK14(2), NCL(7) 10521056 32 29 31 10 0 1 11 11 9 0 0.681 1.000 1.000 376 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(16), LPL(6), NCOA1(5), NCOA2(13), PPARG(3), RXRA(2) 21621825 58 50 49 16 4 8 7 12 27 0 0.556 1.000 1.000 377 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(11), CDH1(3), CREBBP(13), EP300(16), MAP3K7(3), MAPK3(3), SKIL(3), TGFB2(2), TGFBR1(1), TGFBR2(1) 30285983 56 52 53 12 3 4 13 18 18 0 0.247 1.000 1.000 378 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), ESCO1(4), ESCO2(1), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), MPO(5), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(3), TPO(4) 39881575 59 55 56 11 5 8 11 14 21 0 0.136 1.000 1.000 379 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), IKBKAP(3), IKBKB(3), LTA(1), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(2), TRAF2(1), TRAF3(1) 26848456 35 31 32 9 2 6 1 11 14 1 0.683 1.000 1.000 380 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), CBL(2), CFLAR(3), E2F1(1), FOS(1), GRB2(3), HRAS(1), IL2RA(2), IL2RB(2), IRS1(6), JAK1(6), JAK3(4), MAPK1(1), MAPK3(3), MYC(1), PIK3CA(16), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(5), RPS6KB1(2), SHC1(4), SOCS1(1), SOCS3(2), SOS1(7), STAT5A(4), STAT5B(4), SYK(2) 41897229 93 85 86 20 11 19 14 26 23 0 0.0753 1.000 1.000 381 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PIK3CA(16), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2) 39651490 63 58 57 12 11 14 4 26 8 0 0.0393 1.000 1.000 382 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(5), ALOX5(4), CBR1(3), CYP4F2(5), CYP4F3(3), EPX(2), GGT1(4), LPO(2), LTA4H(4), MPO(5), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX5(2), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4) 32741552 67 62 65 15 6 8 14 22 16 1 0.239 1.000 1.000 383 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(8), ACADL(3), ACADM(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2) 39207224 74 69 70 16 5 8 17 24 19 1 0.182 1.000 1.000 384 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(5), DIAPH1(7), FYN(2), GSN(4), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PFN1(1), PIK3CA(16), PIK3R1(5), PTK2(3), PXN(3), RAF1(5), ROCK1(7), SHC1(4), SRC(2), TLN1(12) 44083344 101 88 94 21 9 18 8 36 30 0 0.140 1.000 1.000 385 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(4), AKT3(2), CISH(2), GRB2(3), IARS(4), IL13RA1(2), IL4(1), IL4R(5), INPP5D(2), JAK1(6), JAK2(7), JAK3(4), PI3(1), PIK3CA(16), PPP1R13B(6), RPS6KB1(2), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT6(4), TYK2(7) 43084286 99 84 92 21 7 20 17 34 21 0 0.0734 1.000 1.000 386 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(3), ALG5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1B1(2), MGAT4A(3), MGAT4B(2), MGAT5(4), RPN1(4), RPN2(2), ST6GAL1(1) 23022326 41 40 41 10 1 9 1 13 17 0 0.534 1.000 1.000 387 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(1), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(15), KDR(6), NOS3(3), PDE2A(1), PDE3A(5), PDE3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKG1(5), PRKG2(4), RYR2(16), SLC7A1(3), SYT1(1), TNNI1(2) 48449080 92 83 92 19 16 16 8 32 20 0 0.0507 1.000 1.000 388 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), FTCD(3), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2) 46326109 79 70 76 15 7 13 13 27 19 0 0.0614 1.000 1.000 389 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(3), PSMC3(1), PSMD1(3), PSMD11(3), PSMD12(2), PSMD13(3), PSMD2(8), PSMD6(2) 19030475 40 36 39 10 1 3 5 15 16 0 0.679 1.000 1.000 390 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(2), PLCG1(3), PRKCA(3), PTK2B(4), SYT1(1) 16069405 20 19 19 9 2 4 2 7 5 0 0.933 1.000 1.000 391 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(11), CD2(2), CD33(4), CD5(2), CD7(2), IFNA1(1), IFNB1(2), IFNG(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(2), TLR7(5), TLR9(1) 21545439 49 45 48 14 5 6 12 12 14 0 0.371 1.000 1.000 392 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(6), GNAI1(3), GNB1(3), MAP3K7(3), PIK3CA(16), PIK3R1(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2B(4), ROCK1(7) 30188462 68 63 62 16 9 13 4 26 16 0 0.296 1.000 1.000 393 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(2), ACADS(3), ACAT1(1), ACSM1(2), AKR1B10(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADH(1), HADHA(4), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), ILVBL(5), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(4), PRDX6(2), RDH11(4), RDH12(3), RDH13(1) 48158232 87 80 83 18 9 11 13 30 24 0 0.116 1.000 1.000 394 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFAT5(9), PDE6A(2), PDE6B(6), PDE6C(2), SLC6A13(7), TF(1) 42372108 74 68 74 16 7 8 17 27 15 0 0.163 1.000 1.000 395 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(13), EP300(16), IKBKB(3), IL1B(1), MAP2K3(3), MAP3K7(3), MAPK11(1), MAPK14(2), NFKB1(1), NFKBIA(1), NR3C1(4), RELA(7), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1) 34785504 63 56 57 14 3 7 8 17 27 1 0.535 1.000 1.000 396 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), MAOA(2), MAOB(3), TAT(3), TH(4), TPO(4), TYR(5) 37027990 76 69 72 20 10 7 9 26 24 0 0.490 1.000 1.000 397 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), AKT1(1), BAX(1), CSF2RB(7), IGF1R(4), IL3(1), KITLG(2), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 25583271 51 49 45 14 9 11 3 19 9 0 0.248 1.000 1.000 398 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), DHRS2(1), DHRSX(5), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3) 29324110 32 29 27 7 1 4 2 13 12 0 0.642 1.000 1.000 399 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG5(1), ALG6(3), ALG8(1), ALG9(3), B4GALT1(2), B4GALT2(1), B4GALT3(2), DHDDS(1), DOLPP1(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), RPN1(4), RPN2(2), ST6GAL1(1), STT3B(4) 49761174 91 77 90 18 3 17 6 31 34 0 0.196 1.000 1.000 400 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), NOS1(10), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), SYT1(1) 30018132 57 52 56 15 9 8 6 25 9 0 0.293 1.000 1.000 401 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(13), EP300(16), NCOA3(8), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RARA(4), RXRA(2) 24157141 56 54 53 16 3 6 11 17 19 0 0.474 1.000 1.000 402 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(3), NMNAT3(2), NNMT(1), NNT(9), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT12(2), QPRT(1) 25362589 43 42 43 12 5 5 4 21 8 0 0.560 1.000 1.000 403 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(6), ARHGEF5(4), ARPC1B(1), ARPC2(8), BAIAP2(3), CFL1(1), DIAPH1(7), GSN(4), LIMK1(6), MYL2(1), MYLK(5), OPHN1(2), PFN1(1), PIP5K1A(2), PPP1R12B(3), ROCK1(7), SRC(2), TLN1(12), VCL(3) 54402062 92 81 83 17 4 9 8 28 43 0 0.228 1.000 1.000 404 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(5), COMT(1), DBH(2), DDC(3), GAD1(2), GAD2(3), HDC(1), MAOA(2), PAH(5), SLC18A3(2), TH(4), TPH1(3) 16415602 34 32 32 11 3 5 8 9 9 0 0.694 1.000 1.000 405 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(2), COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), REN(1) 30108508 44 42 44 13 5 15 4 13 7 0 0.388 1.000 1.000 406 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), ASS1(2), CPS1(5), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(1), SAT1(1), SAT2(1), SMS(2) 34487137 60 60 58 15 4 6 10 20 20 0 0.459 1.000 1.000 407 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(10), MAP3K1(8), MAPK14(2), NCOR2(7), RARA(4), RXRA(2), THRA(2) 20230386 40 34 37 11 2 6 7 13 12 0 0.646 1.000 1.000 408 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), ILVBL(5), PANK1(4), PANK2(5), PANK3(2), PANK4(1), PPCDC(1), UPB1(2), VNN1(1) 20256946 36 35 36 11 3 4 6 11 12 0 0.670 1.000 1.000 409 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(2), CA1(1), CA12(1), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS(9), GLS2(4), GLUD1(1), GLUL(2), HAL(1) 22294428 37 36 37 10 1 4 6 20 6 0 0.603 1.000 1.000 410 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CSK(4), DAG1(3), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), LYN(3), MAP2K2(1), MAPK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6) 61202636 115 102 109 22 13 22 16 44 20 0 0.0146 1.000 1.000 411 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(1), MAP3K1(8), MAPK1(1), MAPK3(3), NFKB1(1), NSMAF(6), RAF1(5), RELA(7), RIPK1(2), SMPD1(5), TNFRSF1A(1), TRADD(2), TRAF2(1) 23980385 44 38 39 12 6 5 6 12 14 1 0.584 1.000 1.000 412 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(2), ARG2(1), ASL(4), ASS1(2), CKB(1), CKMT1B(1), CPS1(5), DAO(1), EPRS(3), GATM(2), GLUD1(1), GLUD2(1), GOT1(3), GOT2(3), LAP3(4), NOS1(10), NOS3(3), OAT(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(4), PRODH(2), PYCR1(1), PYCR2(3), PYCRL(2), RARS(4), RARS2(2) 42627273 78 69 78 17 7 7 16 25 23 0 0.239 1.000 1.000 413 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL6R(2), IL6ST(5), JAK1(6), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(1), RAF1(5), SHC1(4), SOS1(7), STAT3(4) 27759968 60 56 60 16 5 8 11 24 12 0 0.486 1.000 1.000 414 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(2), ASRGL1(4), CA1(1), CA12(1), CA13(2), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS(9), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), HAL(1) 24874778 44 43 41 12 2 5 6 21 10 0 0.610 1.000 1.000 415 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(1), CD3G(2), ELK1(2), FOS(1), FYN(2), GRB2(3), HRAS(1), JUN(2), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(16), PIK3R1(5), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PTPN7(1), RAF1(5), RASA1(7), RELA(7), SHC1(4), SOS1(7), SYT1(1), VAV1(6), ZAP70(1) 55597960 122 108 110 27 12 26 11 36 36 1 0.201 1.000 1.000 416 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(23), CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CREB3L1(3), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(2), GBA2(6), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MNAT1(1), MYC(1), MYT1(9), NACA(11), PCNA(3), POLE(6), POLE2(1), PRIM1(2), RB1(4), RPA1(2), RPA2(2), RPA3(1), TFDP2(5), TNXB(11), TP53(50), WEE1(2) 89390237 215 155 191 38 20 27 22 62 77 7 0.00288 1.000 1.000 417 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), PGD(1) 21893256 43 37 40 12 2 3 15 12 11 0 0.516 1.000 1.000 418 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(3), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(8), GUCA1B(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(5), PRKG2(4), PRKX(2) 36410808 57 55 54 14 6 11 3 26 11 0 0.332 1.000 1.000 419 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADH(1), HADHA(4), HSD17B4(1), NSD1(12), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(3), PLOD2(7), PLOD3(12), RDH11(4), RDH12(3), RDH13(1), SETD1A(9), SETD7(1), SETDB1(8), SHMT1(4), SHMT2(6), SPCS1(2), SPCS3(1), SUV39H1(1), SUV39H2(5), TMLHE(1) 67274737 167 133 154 30 12 26 23 53 51 2 0.0208 1.000 1.000 420 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(5), ALOX12B(2), ALOX15B(4), ALOX5(4), CBR1(3), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP2U1(1), CYP4A11(6), CYP4F2(5), CYP4F3(3), DHRS4(4), EPHX2(2), GGT1(4), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 46092757 85 75 83 19 8 9 17 26 23 2 0.218 1.000 1.000 421 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CSK(4), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(3), FBXW7(5), GRAP2(1), GRB2(3), ITK(2), ITPKA(1), ITPKB(3), LCK(1), LCP2(2), MAPK1(1), NCK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLCG1(3), PTPRC(7), RAF1(5), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), SOS1(7), SOS2(7), VAV1(6), ZAP70(1) 65679431 122 105 121 25 14 15 20 43 30 0 0.0770 1.000 1.000 422 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(1), BAX(1), BFAR(2), CAD(13), CASP10(3), CASP8(1), CD7(2), CSNK1A1(2), DAXX(6), DEDD(2), DFFA(1), EGFR(10), EPHB2(3), FAF1(1), FAIM2(1), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(28), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PFN1(1), PTPN13(10), RALBP1(3), RIPK1(2), ROCK1(7), SMPD1(5), TP53(50), TPX2(2), TRAF2(1) 86134889 203 161 176 35 22 24 26 76 50 5 0.00215 1.000 1.000 423 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(2), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), PON1(1) 34004058 68 58 68 18 13 11 2 28 13 1 0.304 1.000 1.000 424 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(8), ACACB(5), ACADM(3), ACAT1(1), ACSS1(3), ACSS2(8), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2) 46974815 86 75 81 20 5 8 19 25 27 2 0.318 1.000 1.000 425 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), F10(1), F11(2), F12(9), F2(4), F2R(2), F5(11), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), PROC(3), PROS1(5), SERPING1(2) 52653516 96 85 94 25 13 19 8 29 26 1 0.243 1.000 1.000 426 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3) 28671173 43 40 39 12 3 7 4 15 13 1 0.634 1.000 1.000 427 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(6), ILVBL(5), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(6) 20868482 39 34 39 11 3 6 7 13 10 0 0.539 1.000 1.000 428 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(4), AKT3(2), ANKRD6(2), APC(11), AXIN1(5), AXIN2(3), CER1(1), CSNK1A1(2), CTNNB1(4), DACT1(2), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(15), MVP(4), NKD1(4), NKD2(3), PSEN1(1), PTPRA(5), SENP2(2), WIF1(5) 47158166 83 75 79 19 7 12 10 32 22 0 0.176 1.000 1.000 429 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(11), ASAH1(2), CERK(6), CREB1(1), CREB5(3), DAG1(3), EPHB2(3), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 32858438 50 46 47 13 7 4 7 17 15 0 0.531 1.000 1.000 430 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(1), FUCA2(1), GALNS(6), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NAGLU(3), NEU1(1), SPAM1(8) 40294545 77 66 77 20 11 11 10 28 17 0 0.184 1.000 1.000 431 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), GTF2I(3), GTF2IRD1(2), STON1(2), TAF1(7), TAF12(1), TAF1L(7), TAF2(7), TAF4(5), TAF4B(7), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(8), TAF9(1), TAF9B(2), TBPL2(1) 43296524 80 73 76 19 7 13 11 25 24 0 0.190 1.000 1.000 432 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(3), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS16(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS8(1), RPS9(1), RPSA(1) 25781109 60 58 60 14 5 5 8 26 15 1 0.452 1.000 1.000 433 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(1), AKT1(1), AKT2(4), AKT3(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(6), PITX2(2), PLD1(3), PLD2(5), PLD3(4), VN1R1(1) 53066720 83 72 81 18 9 13 17 25 19 0 0.0587 1.000 1.000 434 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), ECH1(3), ESCO1(4), ESCO2(1), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PNPLA3(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SH3GLB1(3), TAT(3), TH(4), TPO(4), TYR(5), TYRP1(4) 69431386 117 100 113 25 11 13 17 42 34 0 0.152 1.000 1.000 435 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), SOAT2(2), SRD5A1(1) 27415383 46 45 42 14 4 2 5 22 13 0 0.802 1.000 1.000 436 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(2), ALDOA(2), ALDOB(5), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(1), RDH11(4), RDH12(3), RDH13(1), SORD(10), TPI1(1) 43868505 77 71 69 19 11 8 11 22 25 0 0.437 1.000 1.000 437 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(2), GNA12(1), GNA13(6), GNB1(3), MYL2(1), MYLK(5), PLCB1(3), PPP1R12B(3), PRKCA(3), ROCK1(7) 24187672 39 39 39 11 3 3 1 19 13 0 0.774 1.000 1.000 438 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), ACAT1(1), ACMSD(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP1A1(1), CYP1A2(6), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADH(1), HADHA(4), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), LCMT2(4), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(4), OGDH(8), OGDHL(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), TDO2(1), TPH1(3), TPH2(2), WARS(1), WARS2(1) 71060684 127 110 122 27 12 20 23 44 28 0 0.0623 1.000 1.000 439 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNA(2), LMNB1(4), LMNB2(2), PRF1(1) 22532667 39 37 39 11 0 8 8 13 10 0 0.496 1.000 1.000 440 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), CREB1(1), ELK1(2), FOS(1), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RAF1(5), RPS6KA3(2), SYT1(1) 40166491 77 69 74 20 9 9 8 26 25 0 0.554 1.000 1.000 441 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(4), HDAC5(3), IGF1R(4), INS(1), INSR(4), MAPK14(2), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NFATC1(4), NFATC2(6), PIK3CA(16), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYT1(1) 40414314 77 70 66 21 11 13 6 25 22 0 0.381 1.000 1.000 442 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(1), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), SYT1(1), VIPR2(1) 32205681 57 51 51 16 6 6 3 16 25 1 0.756 1.000 1.000 443 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(3), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTK2(3), PXN(3), TLN1(12) 38697850 76 68 73 21 10 8 7 27 24 0 0.511 1.000 1.000 444 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(7), JAK3(4), SOCS3(2), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), TYK2(7) 21777380 49 47 47 15 4 1 10 17 17 0 0.895 1.000 1.000 445 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(9), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(11), CMA1(2), CTSA(2), ENPEP(5), LNPEP(4), MAS1(2), MME(6), REN(1), THOP1(1) 24777470 52 45 48 16 3 5 16 18 10 0 0.621 1.000 1.000 446 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(2), IKBKB(3), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K7(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2) 28790971 45 39 42 12 4 9 3 11 17 1 0.637 1.000 1.000 447 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CD3G(2), ETV5(3), IFNG(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), JAK2(7), JUN(2), MAPK14(2), STAT4(2), TYK2(7) 22004144 37 36 36 11 3 1 6 17 10 0 0.816 1.000 1.000 448 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(1), AKT2(4), AKT3(2), BCL10(2), CARD11(9), CBL(2), CBLB(5), CBLC(2), CD28(1), CD3E(1), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(7), CHUK(2), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(3), HRAS(1), ICOS(3), IFNG(2), IKBKB(3), IL2(1), IL4(1), ITK(2), JUN(2), KRAS(6), LCK(1), LCP2(2), MALT1(2), MAP3K8(1), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(7), RASGRP1(3), SOS1(7), SOS2(7), TEC(5), TNF(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1) 119166997 254 188 229 40 21 37 32 98 65 1 0.000968 1.000 1.000 449 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAX(1), BCL2A1(2), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKE(3), LTA(1), MCL1(1), NFKB1(1), NFKBIA(1), NGFR(2), NR3C1(4), NTRK1(6), PTPN13(10), RIPK1(2), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 51089403 77 69 76 17 4 14 12 30 17 0 0.200 1.000 1.000 450 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(4), CYP1A2(6), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH12(3), RDH13(1) 28365685 46 43 46 13 5 6 4 19 11 1 0.493 1.000 1.000 451 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), ARHGAP5(5), BCAR1(5), BIRC2(3), BIRC3(6), BRAF(6), CAPN2(3), CAV2(2), CAV3(1), CCND2(1), CCND3(1), CDC42(1), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), CTNNB1(4), DIAPH1(7), DOCK1(2), EGF(5), EGFR(10), ELK1(2), ERBB2(8), FARP2(3), FIGF(2), FLNA(5), FLNB(7), FLNC(7), FLT1(8), FN1(8), FYN(2), GRB2(3), GSK3B(3), HGF(2), HRAS(1), IBSP(1), IGF1R(4), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), JUN(2), KDR(6), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MET(28), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PGF(2), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PRKCA(3), PRKCG(5), PTEN(35), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF1(6), RELN(8), ROCK1(7), ROCK2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SPP1(3), SRC(2), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TLN1(12), TLN2(12), TNC(11), TNN(3), TNR(9), TNXB(11), VAV1(6), VAV2(4), VAV3(2), VCL(3), VEGFA(1), VEGFC(2), VTN(1), VWF(15), ZYX(1) 435046607 861 460 823 228 88 130 104 287 242 10 0.0651 1.000 1.000 452 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(4), ACVR1C(3), AKT1(1), AKT2(4), AKT3(2), ARRB1(2), ARRB2(1), ATF2(3), ATF4(2), BDNF(2), BRAF(6), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D3(1), CACNA2D4(6), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(3), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(2), ELK4(2), FAS(2), FASLG(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FLNA(5), FLNB(7), FLNC(7), FOS(1), GADD45B(2), GNA12(1), GNG12(1), GRB2(3), HRAS(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(7), JUN(2), KRAS(6), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(2), MAPT(5), MAX(5), MEF2C(1), MKNK1(2), MKNK2(2), MOS(1), MRAS(1), MYC(1), NF1(15), NFATC2(6), NFATC4(3), NFKB1(1), NFKB2(3), NR4A1(1), NRAS(3), NTRK1(6), NTRK2(3), PAK1(4), PAK2(4), PDGFRA(6), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(1), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(6), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF2(7), RASA1(7), RASA2(1), RASGRF1(11), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(8), SOS1(7), SOS2(7), STK3(1), STMN1(1), TAOK2(4), TAOK3(3), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(50), TRAF2(1), TRAF6(2), ZAK(5) 340144446 678 396 642 160 81 91 86 230 183 7 0.00489 1.000 1.000 453 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(1), ACTN2(3), ACTN4(4), APC(11), APC2(5), ARHGEF1(2), ARHGEF12(4), ARHGEF4(2), ARHGEF6(3), ARHGEF7(6), ARPC1B(1), ARPC2(8), ARPC5L(1), BAIAP2(3), BCAR1(5), BDKRB1(1), BDKRB2(1), BRAF(6), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CSK(4), CYFIP1(7), CYFIP2(6), DIAPH1(7), DIAPH2(3), DIAPH3(7), DOCK1(2), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(2), FGD3(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FN1(8), GIT1(2), GNA12(1), GNA13(6), GNG12(1), GSN(4), HRAS(1), INS(1), IQGAP1(5), IQGAP2(6), IQGAP3(7), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), KRAS(6), LIMK1(6), LIMK2(3), MAP2K2(1), MAPK1(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(6), MYH14(10), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), NCKAP1(2), NCKAP1L(6), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDGFRA(6), PDGFRB(3), PFN1(1), PFN3(1), PFN4(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PPP1R12B(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RDX(2), ROCK1(7), ROCK2(3), RRAS2(8), SCIN(4), SLC9A1(3), SOS1(7), SOS2(7), SSH1(4), SSH2(13), SSH3(2), TIAM1(9), TIAM2(2), VAV1(6), VAV2(4), VAV3(2), VCL(3), WAS(1), WASF1(1), WASF2(2), WASL(9) 327913212 649 396 608 155 61 79 88 240 177 4 0.0276 1.000 1.000 454 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY7(2), ADCY8(12), ADCY9(8), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(3), CD38(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(7), ERBB4(11), F2R(2), GNA14(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(10), GRIN2D(3), GRM1(5), GRM5(8), GRPR(2), HRH2(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), LHCGR(1), LTB4R2(2), MYLK(5), MYLK2(1), NOS1(10), NOS3(3), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), PDE1A(1), PDE1B(6), PDE1C(3), PDGFRA(6), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PPID(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(5), PTK2B(4), RYR1(23), RYR2(16), RYR3(19), SLC25A4(2), SLC25A5(3), SLC25A6(2), SLC8A1(4), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(4), VDAC2(1), VDAC3(3) 319810401 604 386 584 175 94 84 66 209 151 0 0.158 1.000 1.000 455 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(4), ACTG1(3), CHAD(5), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DES(1), DSC2(4), DSC3(2), DSG1(5), DSG2(3), DSG3(3), DSG4(4), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(1), GJA9(1), GJB1(2), GJB3(4), GJB6(2), GJB7(1), GJC1(3), GJC2(1), GJC3(1), GJD2(1), IBSP(1), ITGA6(7), ITGB4(7), KRT1(2), KRT10(4), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(4), KRT19(3), KRT2(9), KRT20(1), KRT23(4), KRT24(2), KRT25(2), KRT27(5), KRT28(2), KRT3(7), KRT31(1), KRT32(1), KRT33A(1), KRT33B(3), KRT34(1), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(1), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(4), KRT73(3), KRT74(2), KRT75(3), KRT76(4), KRT77(2), KRT78(3), KRT79(4), KRT81(1), KRT82(3), KRT83(2), KRT84(4), KRT85(6), KRT86(3), KRT9(2), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), LMNA(2), LMNB1(4), LMNB2(2), NES(6), PRPH(2), RELN(8), SPP1(3), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15) 289055100 565 361 548 193 69 87 61 179 166 3 0.913 1.000 1.000 456 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(11), CD44(3), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DAG1(3), FN1(8), FNDC1(2), FNDC3A(3), FNDC5(1), HMMR(1), HSPG2(16), IBSP(1), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), RELN(8), SDC1(1), SDC3(1), SDC4(2), SPP1(3), SV2A(2), SV2B(3), SV2C(3), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15) 261428285 481 327 468 143 50 73 54 156 144 4 0.504 1.000 1.000 457 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), C5AR1(2), CALCR(5), CALCRL(3), CCKAR(4), CCKBR(3), CGA(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(4), CYSLTR1(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(6), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(4), GABRB3(3), GABRD(2), GABRE(4), GABRG1(3), GABRG2(7), GABRG3(3), GABRP(1), GABRQ(9), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(5), GLRA1(5), GLRA2(1), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(9), GRIA2(5), GRIA3(2), GRIA4(4), GRID1(4), GRID2(8), GRIK1(2), GRIK2(4), GRIK3(5), GRIK4(1), GRIK5(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRIN3A(3), GRIN3B(3), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM6(3), GRM7(5), GRM8(3), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HRH4(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LEP(1), LEPR(5), LHCGR(1), LTB4R2(2), MAS1(2), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY1R(2), NPY2R(3), NR3C1(4), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), P2RY1(3), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(2), P2RY8(3), PARD3(7), PRLR(3), PRSS1(6), PRSS3(11), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGER4(1), PTGFR(5), PTGIR(1), RXFP1(3), RXFP2(1), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAAR2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(3), TSHR(3), TSPO(1), VIPR1(1), VIPR2(1) 255226311 494 321 478 145 68 68 68 180 109 1 0.162 1.000 1.000 458 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), AMOTL1(3), ASH1L(8), CASK(1), CDC42(1), CDK4(7), CGN(3), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CRB3(1), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(8), EXOC4(4), F11R(1), GNAI1(3), GNAI2(3), HCLS1(1), HRAS(1), IGSF5(5), INADL(8), JAM3(3), KRAS(6), LLGL1(6), LLGL2(2), MAGI1(5), MAGI2(4), MAGI3(5), MLLT4(12), MPDZ(4), MPP5(1), MRAS(1), MYH1(7), MYH10(6), MYH11(9), MYH13(7), MYH14(10), MYH15(6), MYH2(9), MYH3(7), MYH4(16), MYH6(8), MYH7(15), MYH7B(7), MYH8(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), NRAS(3), OCLN(3), PARD3(7), PARD6B(11), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP2R3A(2), PPP2R3B(1), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PTEN(35), RRAS2(8), SPTAN1(11), SRC(2), SYMPK(3), TJAP1(3), TJP1(5), TJP2(5), TJP3(2), YES1(2), ZAK(5) 228342188 467 310 440 133 39 51 62 144 165 6 0.728 1.000 1.000 459 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB1(2), ARRB2(1), ATP1A4(5), ATP1B1(7), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(4), GJB6(2), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), ITPR1(11), ITPR2(14), ITPR3(7), KCNB1(4), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PLCB3(4), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SLC8A3(4), USP5(4), YWHAB(1) 223652632 430 302 419 137 73 49 44 147 117 0 0.590 1.000 1.000 460 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(6), ABLIM1(5), ABLIM2(1), ABLIM3(3), ARHGEF12(4), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(8), DPYSL2(3), EFNA1(3), EFNA2(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(12), EPHA1(4), EPHA2(1), EPHA3(8), EPHA4(3), EPHA5(8), EPHA6(4), EPHA7(2), EPHA8(3), EPHB1(3), EPHB2(3), EPHB3(1), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(3), GNAI2(3), GSK3B(3), HRAS(1), ITGB1(6), KRAS(6), L1CAM(5), LIMK1(6), LIMK2(3), LRRC4C(2), MAPK1(1), MAPK3(3), MET(28), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NGEF(2), NRAS(3), NRP1(2), NTN1(1), NTN4(2), NTNG1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLXNA1(3), PLXNA2(9), PLXNA3(5), PLXNB1(8), PLXNB2(7), PLXNB3(3), PLXNC1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTK2(3), RAC2(1), RAC3(1), RASA1(7), RGS3(6), RND1(2), ROBO1(5), ROBO2(9), ROBO3(3), ROCK1(7), ROCK2(3), SEMA3A(3), SEMA3C(2), SEMA3D(3), SEMA3E(4), SEMA3F(4), SEMA3G(1), SEMA4A(2), SEMA4B(1), SEMA4C(2), SEMA4D(2), SEMA4F(8), SEMA4G(4), SEMA5A(6), SEMA5B(1), SEMA6A(5), SEMA6B(1), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(10), SLIT3(7), SRGAP1(9), SRGAP2(1), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(4), UNC5D(2) 228798870 447 298 404 129 38 53 54 158 142 2 0.763 1.000 1.000 461 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(1), ACVR1B(4), ACVR2A(5), ACVR2B(1), AMHR2(9), BMP2(1), BMP7(5), BMPR1A(2), BMPR1B(1), BMPR2(6), CCL2(1), CCL27(3), CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CD27(2), CD40(1), CLCF1(1), CNTF(2), CSF1R(8), CSF2RA(3), CSF2RB(7), CSF3R(3), CX3CL1(2), CX3CR1(1), CXCL11(1), CXCL13(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(3), EDA(1), EDA2R(1), EGF(5), EGFR(10), EPOR(1), FAS(2), FASLG(2), FLT1(8), FLT3(7), FLT4(15), GDF5(3), GH2(1), GHR(1), HGF(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL17RA(2), IL17RB(3), IL18(1), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(7), IL1RAP(4), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), INHBA(2), INHBB(2), INHBC(1), INHBE(2), KDR(6), KITLG(2), LEP(1), LEPR(5), LIF(1), LIFR(4), LTA(1), LTB(1), LTBR(3), MET(28), NGFR(2), OSM(1), OSMR(1), PDGFC(1), PDGFRA(6), PDGFRB(3), PF4(1), PLEKHO2(2), PRLR(3), RELT(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF4(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(9), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFA(1), VEGFC(2), XCL1(2), XCR1(1) 207849188 392 283 369 75 38 55 51 152 96 0 0.000738 1.000 1.000 462 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(11), APC2(5), AXIN1(5), AXIN2(3), BTRC(4), CACYBP(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(1), CHD8(8), CREBBP(13), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(1), CTNNB1(4), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(3), DVL1(1), DVL2(1), DVL3(1), EP300(16), FBXW11(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(10), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKD1(4), NKD2(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRICKLE1(5), PRICKLE2(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(7), ROCK2(3), RUVBL1(1), SENP2(2), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(3), SMAD3(2), SMAD4(4), SOX17(1), TBL1X(4), TBL1XR1(4), TCF7L1(3), TCF7L2(1), TP53(50), VANGL1(3), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3) 186982200 404 283 385 94 41 45 57 135 122 4 0.0343 1.000 1.000 463 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(8), ACACB(5), AKT1(1), AKT2(4), AKT3(2), BRAF(6), CALM2(1), CBL(2), CBLB(5), CBLC(2), ELK1(2), EXOC7(8), FASN(8), FLOT1(1), FLOT2(1), FOXO1(3), G6PC(3), GCK(1), GRB2(3), GSK3B(3), GYS1(3), GYS2(2), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(4), IRS1(6), IRS4(1), KRAS(6), LIPE(5), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(2), NRAS(3), PCK1(9), PCK2(2), PDE3A(5), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PKLR(1), PPARGC1A(3), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKAR1A(3), PRKAR2B(4), PRKCI(5), PRKCZ(1), PRKX(2), PTPN1(2), PTPRF(6), PYGB(3), PYGL(1), PYGM(4), RAF1(5), RAPGEF1(6), RHEB(4), RHOQ(2), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS3(2), SOCS4(1), SORBS1(2), SOS1(7), SOS2(7), SREBF1(4), TRIP10(2), TSC1(5), TSC2(14) 186862346 363 268 338 74 37 57 50 133 82 4 0.00102 1.000 1.000 464 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ARRB1(2), ARRB2(1), ATF1(2), ATF2(3), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN2(3), CORIN(2), CRH(1), CRHR1(2), DGKZ(3), ETS2(1), FOS(1), GABPA(1), GABPB2(2), GBA2(6), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(2), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), MIB1(1), MYL2(1), MYL4(1), MYLK2(1), NFKB1(1), NOS1(10), NOS3(3), OXT(1), OXTR(1), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(4), PLCD1(3), PLCG1(3), PLCG2(3), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RLN1(1), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SP1(2), TNXB(11), USP5(4), YWHAB(1) 203596345 357 261 350 106 53 51 37 121 95 0 0.524 1.000 1.000 465 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(2), CADM3(2), CD2(2), CD22(4), CD226(1), CD276(2), CD28(1), CD34(2), CD4(10), CD40(1), CD58(1), CD6(4), CD80(1), CD86(3), CD8A(1), CD99(1), CDH1(3), CDH2(7), CDH3(4), CDH4(5), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(8), CNTN2(4), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(7), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(7), ITGA8(2), ITGA9(3), ITGAL(6), ITGAM(9), ITGAV(2), ITGB1(6), ITGB2(2), ITGB7(4), ITGB8(3), JAM3(3), L1CAM(5), MADCAM1(3), MAG(4), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(6), NFASC(8), NLGN1(1), NLGN2(1), NRCAM(3), NRXN1(10), NRXN2(4), NRXN3(4), OCLN(3), PTPRC(7), PTPRF(6), PTPRM(10), PVRL2(5), PVRL3(4), SDC1(1), SDC3(1), SDC4(2), SELE(5), SELL(2), SELP(2), SELPLG(3), SIGLEC1(4), SPN(1), VCAM1(5), VCAN(11) 170313611 363 250 351 112 29 48 46 144 95 1 0.712 1.000 1.000 466 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 AKT1(1), AKT2(4), AKT3(2), CBL(2), CBLB(5), CBLC(2), CCND2(1), CCND3(1), CISH(2), CLCF1(1), CNTF(2), CREBBP(13), CSF2RA(3), CSF2RB(7), CSF3R(3), EP300(16), EPOR(1), GH2(1), GHR(1), GRB2(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL19(2), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), IRF9(3), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIF(1), LIFR(4), MYC(1), OSM(1), OSMR(1), PIAS1(5), PIAS2(4), PIAS3(3), PIAS4(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRLR(3), PTPN11(1), PTPN6(3), SOCS1(1), SOCS3(2), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(7), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(2), SPRY2(3), SPRY4(10), STAM(6), STAT1(6), STAT2(7), STAT3(4), STAT4(2), STAT5A(4), STAT5B(4), STAT6(4), TPO(4), TYK2(7) 170784633 350 249 329 81 28 49 60 115 98 0 0.0601 1.000 1.000 467 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADK(2), ADSL(2), ADSSL1(3), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), GART(4), GDA(4), GMPR(3), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(2), NPR1(5), NPR2(7), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(6), PDE1A(1), PDE1C(3), PDE2A(1), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(10), PFAS(4), PKLR(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(2), RRM1(4), RRM2(1), XDH(7) 193492226 331 237 318 74 33 48 36 116 98 0 0.0709 1.000 1.000 468 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), ACVR1B(4), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(3), CREBBP(13), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(4), INSR(4), IQGAP1(5), LEF1(3), LMO7(15), MAP3K7(3), MAPK1(1), MAPK3(3), MET(28), MLLT4(12), PARD3(7), PTPN1(2), PTPN6(3), PTPRB(7), PTPRF(6), PTPRJ(11), PTPRM(10), PVRL2(5), PVRL3(4), RAC2(1), RAC3(1), SMAD2(3), SMAD3(2), SMAD4(4), SNAI1(1), SNAI2(4), SORBS1(2), SRC(2), SSX2IP(3), TCF7L1(3), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(5), VCL(3), WAS(1), WASF1(1), WASF2(2), WASF3(2), WASL(9), YES1(2) 141360553 311 231 283 77 29 37 59 104 81 1 0.1000 1.000 1.000 469 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(6), ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), ATM(23), ATR(11), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDC14A(6), CDC16(4), CDC20(3), CDC23(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC27(10), CDC6(3), CDC7(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(5), DBF4(2), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(11), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), PCNA(3), PKMYT1(1), PLK1(1), PRKDC(10), RB1(4), RBL2(3), RBX1(1), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(4), SMC1A(3), SMC1B(4), TGFB2(2), TP53(50), WEE1(2), YWHAB(1) 161530278 335 227 311 73 24 42 48 104 109 8 0.0113 1.000 1.000 470 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(2), CAPN11(6), CAPN2(3), CAPN3(8), CAPN6(2), CAPN7(4), CAPN9(2), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(2), FYN(2), GIT2(4), GRB2(3), ILK(4), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), MAP2K2(1), MAP2K3(3), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(2), MAPK7(1), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PIK3R2(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(7), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(4), SHC3(1), SORBS1(2), SOS1(7), SRC(2), TLN1(12), TNS1(12), VAV2(4), VAV3(2), VCL(3), ZYX(1) 159277847 303 226 293 93 20 42 38 110 91 2 0.681 1.000 1.000 471 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), DRD1(1), DRD2(2), EGF(5), EGFR(10), GJD2(1), GNAI1(3), GNAI2(3), GNAS(5), GRB2(3), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), MAP2K2(1), MAP2K5(3), MAP3K2(2), MAPK1(1), MAPK3(3), MAPK7(1), NPR1(5), NPR2(7), NRAS(3), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), PRKX(2), RAF1(5), SOS1(7), SOS2(7), SRC(2), TJP1(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4) 155445603 294 221 286 94 35 48 33 111 67 0 0.748 1.000 1.000 472 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ATF4(2), CACNA1C(15), CACNA1D(12), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(2), GNAS(5), GRB2(3), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), KRAS(6), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLD1(3), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(4), RAF1(5), SOS1(7), SOS2(7), SRC(2) 151993866 296 219 287 95 38 50 33 108 67 0 0.595 1.000 1.000 473 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADK(2), ADSL(2), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), ATP1B1(7), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), GART(4), GDA(4), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(5), NPR2(7), NT5C(1), NT5M(3), NUDT2(1), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE6B(6), PDE6C(2), PDE7B(1), PDE8A(2), PDE9A(10), PFAS(4), PKLR(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(4), RRM2(1) 151042938 283 217 272 57 29 36 32 98 88 0 0.0324 1.000 1.000 474 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), OCRL(3), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3C3(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PRKCA(3), PRKCG(5), PTEN(35), PTPMT1(1), SYNJ1(5), SYNJ2(6) 148201525 289 214 278 79 28 45 30 90 91 5 0.357 1.000 1.000 475 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(2), BRAF(6), CD48(1), FAS(2), FASLG(2), FYN(2), GRB2(3), HCST(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(6), ITGB2(2), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(2), KLRK1(3), KRAS(6), LCK(1), LCP2(2), MAP2K2(1), MAPK1(1), MAPK3(3), MICA(2), MICB(3), NCR1(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NRAS(3), PAK1(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRF1(1), PRKCA(3), PRKCG(5), PTK2B(4), PTPN11(1), PTPN6(3), RAC2(1), RAC3(1), RAF1(5), SH2D1B(1), SH3BP2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFSF10(9), ULBP1(1), ULBP2(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1) 132096817 294 214 275 63 26 49 37 110 70 2 0.0282 1.000 1.000 476 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(6), CACNA1A(14), CRH(1), CRHR1(2), GNA12(1), GNA13(6), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(9), GRIA2(5), GRIA3(2), GRID2(8), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), IGF1R(4), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), LYN(3), MAP2K2(1), MAPK1(1), MAPK3(3), NOS1(10), NOS3(3), NPR1(5), NPR2(7), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), RAF1(5), RYR1(23) 130512298 274 214 267 73 43 30 25 106 69 1 0.251 1.000 1.000 477 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(6), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGEF6(3), ARHGEF7(6), BCAR1(5), BRAF(6), CDC42(1), CDKN2A(4), CSE1L(5), DOCK1(2), EPHB2(3), FYN(2), GRB2(3), GRB7(6), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGB3BP(1), MAP2K7(3), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(5), MYLK2(1), P4HB(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CA(16), PIK3CB(6), PKLR(1), PLCG1(3), PLCG2(3), PTEN(35), PTK2(3), RAF1(5), RALA(3), RHO(1), ROCK1(7), ROCK2(3), SHC1(4), SOS1(7), SOS2(7), SRC(2), TERF2IP(1), TLN1(12), TLN2(12), WAS(1), ZYX(1) 144169978 304 214 290 73 18 46 36 101 96 7 0.145 1.000 1.000 478 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(8), ASH2L(2), CTCFL(7), DOT1L(8), EHMT1(4), EHMT2(8), EZH1(4), EZH2(4), FBXO11(5), HCFC1(10), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(13), MEN1(1), NSD1(12), OGT(6), PAXIP1(4), PPP1CC(2), PRDM2(8), PRDM6(2), PRDM7(3), PRDM9(6), PRMT1(1), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), RBBP5(4), SATB1(3), SETD1A(9), SETD1B(1), SETD2(71), SETD7(1), SETDB1(8), SETDB2(1), SETMAR(3), SMYD3(2), SUV39H1(1), SUV39H2(5), SUV420H1(2), SUZ12(6), WHSC1(5), WHSC1L1(5) 143713348 267 212 263 56 17 28 32 78 106 6 0.0576 1.000 1.000 479 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(3), ACTN4(4), ARHGAP5(5), BCAR1(5), CD99(1), CDC42(1), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), CXCR4(1), ESAM(1), EZR(2), F11R(1), GNAI1(3), GNAI2(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), ITK(2), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP2(6), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(2), NCF4(1), NOX1(7), NOX3(6), OCLN(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAC2(1), RAP1A(1), RAPGEF3(2), RAPGEF4(3), ROCK1(7), ROCK2(3), SIPA1(4), THY1(1), VAV1(6), VAV2(4), VAV3(2), VCAM1(5), VCL(3) 146700006 274 204 260 81 32 37 33 97 74 1 0.613 1.000 1.000 480 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(1), BMPR1A(2), BMPR2(6), BUB1(1), CDKL1(1), CDKL2(4), CDS2(1), CLK1(5), CLK2(3), CLK4(8), COL4A3BP(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MAP3K10(4), MOS(1), NEK1(4), NEK3(4), OCRL(3), PAK4(5), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CA(16), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(5), RAF1(5), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KB1(2), STK11(2), TGFBR1(1), VRK1(1) 134166200 260 202 248 56 21 40 29 83 86 1 0.0410 1.000 1.000 481 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(3), ACTN4(4), DES(1), DMD(16), MYBPC1(5), MYBPC2(3), MYBPC3(3), MYH3(7), MYH6(8), MYH7(15), MYH8(8), MYL1(3), MYL2(1), MYL4(1), MYL9(1), MYOM1(6), NEB(18), TCAP(1), TMOD1(6), TNNI1(2), TNNT1(3), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(125), VIM(2) 164621760 249 202 243 78 20 37 34 101 53 4 0.725 1.000 1.000 482 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ASIP(2), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3L1(3), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(13), CTNNB1(4), DCT(5), DVL1(1), DVL2(1), DVL3(1), EDNRB(3), EP300(16), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), KRAS(6), LEF1(3), MAP2K2(1), MAPK1(1), MAPK3(3), MC1R(2), MITF(4), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), POMC(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), TCF7L1(3), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3) 125714313 253 198 242 72 33 36 27 93 64 0 0.294 1.000 1.000 483 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(8), AKAP2(2), AKAP3(3), AKAP4(3), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(20), ARHGEF1(2), CALM2(1), CHMP1B(3), GNA12(1), GNA13(6), GNA14(1), GNA15(1), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG10(1), GNG12(1), GNG13(1), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(4), KRAS(6), NRAS(3), PALM2(1), PDE1A(1), PDE1B(6), PDE1C(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(4), SLC9A1(3), USP5(4) 137815972 260 196 250 75 24 38 17 103 77 1 0.611 1.000 1.000 484 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(6), ABL2(5), AKT1(1), AKT2(4), AKT3(2), AREG(1), BRAF(6), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(5), CBLC(2), CDKN1A(3), CDKN1B(1), EGF(5), EGFR(10), ELK1(2), ERBB2(8), ERBB3(7), ERBB4(11), GAB1(1), GRB2(3), GSK3B(3), HRAS(1), JUN(2), KRAS(6), MAP2K2(1), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(1), NCK1(1), NCK2(1), NRAS(3), NRG1(4), NRG2(3), NRG3(5), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), RAF1(5), RPS6KB1(2), RPS6KB2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SRC(2), STAT5A(4), STAT5B(4) 120995706 259 195 239 53 23 43 36 94 61 2 0.00887 1.000 1.000 485 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CHML(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(5), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR83(2), GPR85(3), GPR87(4), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LHCGR(1), MAS1(2), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMUR2(4), NPY1R(2), NPY2R(3), NTSR1(2), OPN1SW(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(1), OR1Q1(1), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TBXA2R(4), TRHR(2) 137312441 243 193 241 84 37 32 33 99 42 0 0.573 1.000 1.000 486 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENPP1(2), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), G6PC(3), GAA(4), GANC(4), GBA(2), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), IFIH1(2), MGAM(8), MOV10L1(8), NUDT5(4), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SI(9), SKIV2L2(2), SMARCA2(6), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UXS1(1) 151904382 257 192 250 81 17 32 45 84 78 1 0.832 1.000 1.000 487 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(9), ABCA10(8), ABCA12(13), ABCA13(21), ABCA2(3), ABCA3(4), ABCA4(10), ABCA5(8), ABCA6(4), ABCA7(15), ABCA8(7), ABCA9(3), ABCB1(6), ABCB10(1), ABCB11(4), ABCB4(7), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(11), ABCC10(6), ABCC11(6), ABCC12(4), ABCC2(5), ABCC3(10), ABCC4(7), ABCC5(5), ABCC6(10), ABCC8(5), ABCC9(4), ABCD1(3), ABCD2(2), ABCD3(3), ABCD4(4), ABCG1(2), ABCG2(1), ABCG4(8), ABCG5(2), ABCG8(5), CFTR(6), TAP2(1) 139457686 247 187 236 78 16 34 33 96 67 1 0.725 1.000 1.000 488 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(12), ATF4(2), BRAF(6), CACNA1C(15), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(16), GRIA1(9), GRIA2(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRM1(5), GRM5(8), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), MAP2K2(1), MAPK1(1), MAPK3(3), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), RAP1A(1), RAPGEF3(2), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1) 118964286 239 187 223 61 29 32 28 85 63 2 0.165 1.000 1.000 489 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(6), ATM(23), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDAN1(7), CDC14A(6), CDC20(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC6(3), CDC7(1), CDH1(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F5(2), EP300(16), ESPL1(11), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MPEG1(1), PCNA(3), PLK1(1), PRKDC(10), PTPRA(5), RB1(4), SKP2(2), SMAD4(4), TBC1D8(1), TP53(50), WEE1(2) 130833512 270 183 248 60 21 33 42 79 87 8 0.0173 1.000 1.000 490 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(3), CLK3(2), CLK4(8), COL2A1(7), CPSF1(3), CPSF2(3), CPSF3(5), CPSF4(2), CSTF1(1), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(8), DHX15(3), DHX16(4), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(5), GIPC1(2), METTL3(6), NCBP2(1), NONO(2), NUDT21(2), NXF1(5), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(11), PPM1G(3), PRPF18(3), PRPF3(2), PRPF4B(5), PRPF8(15), PSKH1(1), PTBP1(1), PTBP2(2), RBM17(2), RBM5(3), RNGTT(1), RNMT(3), SF3A1(3), SF3A3(2), SF3B1(14), SF3B2(4), SNRPA(1), SNRPA1(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(1), SRPK2(3), SRRM1(4), SUPT5H(7), TXNL4A(1), U2AF2(4), XRN2(3) 124661384 218 183 214 49 16 41 25 79 56 1 0.0842 1.000 1.000 491 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG6(3), ALG8(1), ALG9(3), B3GNT1(2), B3GNT2(4), B3GNT6(3), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT5(3), CHST1(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST2(4), CHST3(2), CHST4(1), CHST6(1), CHST7(1), CHSY1(9), DPAGT1(8), EXT1(3), EXT2(3), EXTL1(2), EXTL2(7), EXTL3(3), FUT11(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), NDST1(3), NDST2(4), NDST4(9), OGT(6), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), WBSCR17(4), XYLT1(4), XYLT2(2) 127816532 255 182 238 69 18 39 25 79 94 0 0.581 1.000 1.000 492 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(5), ACVR2B(1), ACVRL1(1), AMHR2(9), BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(6), CHRD(5), CREBBP(13), CUL1(5), DCN(3), E2F5(2), EP300(16), GDF5(3), GDF6(2), GDF7(1), IFNG(2), INHBA(2), INHBB(2), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(8), MAPK1(1), MAPK3(3), MYC(1), NODAL(2), NOG(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), RBL2(3), RBX1(1), ROCK1(7), ROCK2(3), RPS6KB1(2), RPS6KB2(3), SMAD1(1), SMAD2(3), SMAD3(2), SMAD4(4), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(1), SMURF2(4), SP1(2), TGFB2(2), TGFBR1(1), TGFBR2(1), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(7) 115326172 228 178 215 50 20 17 38 74 79 0 0.125 1.000 1.000 493 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 69 A2M(10), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C1S(16), C2(5), C3(9), C3AR1(4), C4A(1), C4BPA(3), C4BPB(3), C5(7), C5AR1(2), C6(3), C7(4), C8A(3), C8B(2), C8G(2), C9(1), CD46(1), CD55(2), CFB(2), CFH(5), CFI(1), CPB2(6), CR1(11), CR2(4), F10(1), F11(2), F12(9), F13A1(3), F13B(3), F2(4), F2R(2), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), KNG1(5), MASP1(5), MASP2(2), MBL2(2), PLAT(4), PLAUR(2), PLG(6), PROC(3), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(2), TFPI(1), VWF(15) 114736895 236 175 215 49 23 29 25 97 59 3 0.0240 1.000 1.000 494 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(4), CABIN1(11), CALM2(1), CAMK2B(3), CAMK4(3), CD3E(1), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(13), CSNK2A1(3), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(2), EP300(16), FCER1A(1), FKBP1B(1), FOS(1), GATA3(3), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(3), IFNA1(1), IFNB1(2), IFNG(2), IL1B(1), IL2(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(2), KPNA5(2), MAP2K7(3), MAPK14(2), MAPK9(2), MEF2A(2), MEF2D(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(9), OPRD1(3), P2RX7(2), PAK1(4), PPIA(1), PPP3CB(1), PPP3CC(3), PTPRC(7), RELA(7), SFN(1), SLA(1), SP1(2), SP3(3), TNF(1), TRAF2(1), TRPV6(5), VAV1(6), VAV2(4), VAV3(2), XPO5(5) 105905814 214 166 203 53 22 21 34 69 66 2 0.307 1.000 1.000 495 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGAP1(1), ARHGEF11(6), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(11), ITPR2(14), ITPR3(7), LIMK1(6), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(6), PTEN(35), RACGAP1(2), RHO(1), ROCK1(7), ROCK2(3), SAG(5), WASF1(1), WASL(9) 82649431 191 160 182 36 15 34 20 57 61 4 0.0100 1.000 1.000 496 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(11), CD19(1), CD1A(2), CD1B(1), CD1C(3), CD1D(3), CD1E(2), CD2(2), CD22(4), CD33(4), CD34(2), CD38(1), CD3E(1), CD3G(2), CD4(10), CD44(3), CD5(2), CD55(2), CD7(2), CD8A(1), CD9(1), CR1(11), CR2(4), CSF1R(8), CSF2RA(3), CSF3R(3), DNTT(4), EPOR(1), FCER2(1), FCGR1A(1), FLT3(7), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(7), IL2RA(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL7R(1), IL9R(4), ITGA1(8), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGAM(9), ITGB3(4), KITLG(2), MME(6), MS4A1(1), TFRC(4), THPO(1), TNF(1), TPO(4) 96959195 216 159 201 47 16 21 30 71 76 2 0.200 1.000 1.000 497 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(1), AKT2(4), AKT3(2), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(2), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K7(3), MAP3K8(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), RELA(7), RIPK1(2), SPP1(3), STAT1(6), TBK1(4), TICAM1(3), TLR1(4), TLR2(3), TLR3(2), TLR4(2), TLR5(5), TLR6(2), TLR7(5), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2) 104704940 188 155 177 38 20 28 23 78 38 1 0.0287 1.000 1.000 498 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(3), BRAF(6), CEBPA(2), CHUK(2), CREB1(1), DAXX(6), ELK1(2), FOS(1), GRB2(3), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP3K9(4), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK4(2), MAPK6(2), MAPK7(1), MAPK9(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MKNK2(2), MYC(1), NFKB1(1), NFKBIA(1), PAK1(4), PAK2(4), RAF1(5), RELA(7), RIPK1(2), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KB1(2), RPS6KB2(3), SHC1(4), SP1(2), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 113581029 204 153 194 44 19 19 23 71 69 3 0.203 1.000 1.000 499 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5E(2), INPPL1(4), IPMK(1), ITPK1(3), ITPKA(1), ITPKB(3), MINPP1(2), MIOX(2), OCRL(3), PI4KA(11), PI4KB(3), PIK3C3(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PTEN(35), PTPMT1(1), SYNJ1(5), SYNJ2(6) 87420680 183 149 173 51 13 25 18 56 66 5 0.655 1.000 1.000 500 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(1), AKT2(4), AKT3(2), CAMKK1(5), CAMKK2(3), CHUK(2), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), G6PC(3), IKBKB(3), IRS1(6), IRS4(1), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NPY(1), PCK1(9), PCK2(2), POMC(2), PPARGC1A(3), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKCQ(4), PTPN11(1), RELA(7), RXRA(2), RXRB(5), RXRG(2), SLC2A1(1), SLC2A4(3), SOCS3(2), STAT3(4), STK11(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TYK2(7) 96096586 187 148 168 42 14 24 33 59 56 1 0.155 1.000 1.000 501 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(1), AKT2(4), AKT3(2), BCL10(2), BLNK(1), CARD11(9), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(2), JUN(2), KRAS(6), LILRB3(4), LYN(3), MALT1(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(6), VAV2(4), VAV3(2) 87697055 173 146 155 34 18 28 18 66 43 0 0.0243 1.000 1.000 502 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(4), AKT3(2), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(6), MAP2K2(1), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPKAPK2(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NOS3(3), NRAS(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PRKCG(5), PTGS2(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(2), SRC(2), VEGFA(1) 84284599 173 140 159 47 16 30 20 64 43 0 0.321 1.000 1.000 503 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(4), AKT3(2), FCER1A(1), FYN(2), GAB2(1), GRB2(3), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(6), LCP2(2), LYN(3), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(3), PDK1(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PRKCA(3), PRKCD(5), PRKCE(4), RAC2(1), RAC3(1), RAF1(5), SOS1(7), SOS2(7), SYK(2), TNF(1), VAV1(6), VAV2(4), VAV3(2) 84854486 162 139 150 39 18 32 22 62 28 0 0.0703 1.000 1.000 504 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), MAP4K1(3), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPRC(7), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6) 86242412 167 138 155 34 18 29 23 57 40 0 0.0171 1.000 1.000 505 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), CDC42(1), CHUK(2), CSK(4), EGFR(10), F11R(1), GIT1(2), IGSF5(5), IKBKB(3), JAM3(3), JUN(2), LYN(3), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(2), MET(28), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(4), PLCG1(3), PLCG2(3), PTPN11(1), PTPRZ1(15), RELA(7), SRC(2), TCIRG1(1), TJP1(5) 83753173 168 133 149 38 13 21 28 64 40 2 0.156 1.000 1.000 506 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), APH1A(2), CREBBP(13), CTBP1(2), CTBP2(1), DLL1(1), DLL3(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(1), DVL3(1), EP300(16), HDAC1(2), JAG1(10), JAG2(3), MAML1(8), MAML2(5), MAML3(7), NCOR2(7), NCSTN(2), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), NUMB(3), NUMBL(2), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(4), RBPJL(7), SNW1(4) 78961138 165 132 154 65 16 13 20 48 65 3 0.998 1.000 1.000 507 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5E(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), COX10(5), COX15(4), COX17(1), COX5A(1), COX6B2(1), COX7A1(2), COX7C(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB9(1), NDUFC1(2), NDUFS1(8), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA1(2), PPA2(2), SDHA(8), SDHB(1), SDHD(2), TCIRG1(1), UQCRC1(2), UQCRC2(4), UQCRFS1(2) 66091202 148 131 147 36 12 16 27 56 36 1 0.221 1.000 1.000 508 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(2), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(3), UPB1(2), UPP1(3), UPP2(3), UPRT(3) 96314045 164 131 156 33 12 25 22 50 53 2 0.0389 1.000 1.000 509 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(4), ACADL(3), ACADM(3), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(10), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(6), CYP7A1(1), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(2), GK2(3), HMGCS2(3), ILK(4), LPL(6), ME1(1), MMP1(1), NR1H3(2), PCK1(9), PCK2(2), PLTP(2), PPARD(1), PPARG(3), RXRA(2), RXRB(5), RXRG(2), SCP2(3), SLC27A1(2), SLC27A2(1), SLC27A5(3), SLC27A6(6), SORBS1(2), UBC(6), UCP1(1) 76471982 168 130 150 44 11 25 24 64 44 0 0.388 1.000 1.000 510 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(3), ADCY8(12), CACNA1A(14), CACNA1B(9), GNAS(5), GNB1(3), GNB3(2), GNG13(1), GNG3(1), GRM4(5), ITPR3(7), KCNB1(4), PDE1A(1), PLCB2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(5), SCNN1B(5), SCNN1G(2), TAS1R1(2), TAS1R2(6), TAS1R3(6), TAS2R10(1), TAS2R13(2), TAS2R3(14), TAS2R38(3), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R43(8), TAS2R46(2), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 66971776 157 130 146 37 30 18 18 59 32 0 0.0796 1.000 1.000 511 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(1), CITED2(2), CPT1B(1), CREBBP(13), DUT(1), EHHADH(6), EP300(16), FABP1(3), HSD17B4(1), HSPA1A(1), INS(1), JUN(2), LPL(6), MAPK1(1), MAPK3(3), ME1(1), MRPL11(1), MYC(1), NCOA1(5), NCOR1(11), NCOR2(7), NFKBIA(1), NR1H3(2), NR2F1(2), NRIP1(6), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PTGS2(5), RB1(4), RELA(7), RXRA(2), SP1(2), STAT5A(4), STAT5B(4), TNF(1) 74335634 162 130 146 47 10 28 20 50 51 3 0.643 1.000 1.000 512 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(4), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(1), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(2), HELLS(2), IKBKB(3), IRF2(2), IRF4(1), IRF5(3), IRF6(6), IRF7(2), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFSF10(9), TP53(50), TP73(4), TRADD(2), TRAF2(1), TRAF3(1) 67129094 162 125 143 32 10 24 20 50 53 5 0.0299 1.000 1.000 513 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(6), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(3), ETS2(1), ETV6(2), FMN2(8), GRB2(3), KRAS(6), MAPK1(1), MAPK3(3), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), PIWIL1(2), PIWIL2(2), PIWIL3(5), PIWIL4(4), RAF1(5), SOS1(7), SOS2(7), SPIRE1(1), SPIRE2(3) 59823273 142 124 133 31 23 15 20 51 30 3 0.0978 1.000 1.000 514 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1E(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(8), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(29), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(10), PTCH2(3), SHH(3), SMO(5), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3), ZIC2(2) 69031994 145 121 135 41 19 19 14 52 41 0 0.582 1.000 1.000 515 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), FPGS(4), GGH(3), IFIH1(2), MOV10L1(8), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SKIV2L2(2), SMARCA2(6), SMARCA5(3) 73666171 142 120 138 45 10 26 24 44 37 1 0.539 1.000 1.000 516 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(1), CCR5(1), CELSR1(16), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(3), CIDEB(2), EMR2(3), EMR3(9), F2R(2), FSHR(2), GPR116(6), GPR133(7), GPR143(1), GPR17(2), GPR18(2), GPR56(1), GPR61(1), GPR84(3), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(11), LTB4R2(2), NTSR1(2), OR2M4(1), P2RY11(1), P2RY13(1), PTGFR(5), SMO(5), SSTR2(2), TSHR(3), VN1R1(1) 76067456 146 114 141 41 19 17 23 52 35 0 0.348 1.000 1.000 517 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 94 ANK2(20), B3GALT4(2), CDR1(2), DGKI(1), IL6ST(5), PIGK(2), RPL10(1), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL22(3), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(1), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS16(1), RPS19(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(6) 61074475 127 114 123 32 8 11 19 51 36 2 0.527 1.000 1.000 518 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(2), CANX(3), CD4(10), CD74(1), CD8A(1), CIITA(5), CREB1(1), CTSB(4), CTSS(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(3), KLRC1(2), KLRC2(3), KLRC3(2), LTA(1), NFYA(3), NFYC(3), PSME2(2), RFX5(4), RFXAP(1), TAP2(1) 51793597 151 113 142 38 6 22 19 63 39 2 0.565 1.000 1.000 519 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(4), AKT3(2), ASAH1(2), BRAF(6), DAG1(3), DRD2(2), EGFR(10), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PI3(1), PIK3CB(6), PITX2(2), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), RAF1(5), RGS20(1), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT3(4), TERF2IP(1) 68747148 134 113 131 33 14 21 24 42 32 1 0.116 1.000 1.000 520 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(4), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(4), LMNA(2), LMNB1(4), LMNB2(2), MAP2K7(3), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKBIA(1), NUMA1(5), PAK2(4), PRKCD(5), PRKDC(10), PSEN1(1), PSEN2(2), PTK2(3), RASA1(7), RB1(4), RELA(7), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 81693533 137 110 134 40 4 21 22 44 43 3 0.580 1.000 1.000 521 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(2), ATF1(2), BRAF(6), CREB1(1), CREB5(3), CREBBP(13), DAG1(3), EGR1(10), EGR2(1), EGR3(2), EGR4(2), ELK1(2), FRS2(3), JUN(2), MAP1B(12), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(6), PIK3C2G(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), PTPN11(1), RPS6KA3(2), SHC1(4), SRC(2), TERF2IP(1), TH(4) 60111551 130 110 114 31 15 29 13 41 31 1 0.0934 1.000 1.000 522 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(11), AXIN1(5), CCND2(1), CCND3(1), CSNK1E(3), CTNNB1(4), DVL1(1), DVL2(1), DVL3(1), FBXW2(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LDLR(4), MAPK10(2), MAPK9(2), MYC(1), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(1), WNT7B(2) 67682022 123 109 120 31 16 18 10 41 38 0 0.246 1.000 1.000 523 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1C1(2), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(6), CYP1B1(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(4), EPHX1(5), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6) 67975913 130 107 126 33 12 11 22 50 34 1 0.413 1.000 1.000 524 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(12), EEF1A2(4), EEF1B2(3), EEF1D(1), EEF1G(3), EEF2(2), EEF2K(2), EIF1AX(1), EIF2AK1(4), EIF2AK2(4), EIF2AK3(3), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G3(7), EIF5(4), EIF5A(2), EIF5B(1), ETF1(2), GSPT2(1), PABPC1(17), PABPC3(17), PAIP1(4), SLC35A4(3) 51821999 126 106 120 37 16 23 18 38 28 3 0.471 1.000 1.000 525 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AGK(7), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CEL(2), DAK(3), DGAT2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), GK(2), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(5), LIPA(1), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PNPLA3(3), PPAP2B(2), PPAP2C(3) 69487128 122 105 119 31 14 16 15 40 37 0 0.234 1.000 1.000 526 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(8), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GALM(2), GAPDH(3), GAPDHS(4), GCK(1), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGAM4(1), PGK1(3), PGK2(1), PGM1(1), PKLR(1), TPI1(1) 68192556 120 101 110 30 12 10 16 33 47 2 0.513 1.000 1.000 527 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 CALM2(1), ELK1(2), FCER1A(1), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP2K7(3), MAP3K1(8), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PAK2(4), PIK3CA(16), PIK3R1(5), PLA2G4A(2), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6) 49920775 111 96 102 30 13 20 11 38 29 0 0.428 1.000 1.000 528 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(2), G6PC(3), GAA(4), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), MGAM(8), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UXS1(1) 73684147 117 96 114 34 10 11 19 38 39 0 0.747 1.000 1.000 529 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(3), TDO2(1), TPH1(3), WARS(1), WARS2(1) 64531470 119 95 114 30 18 13 16 45 26 1 0.257 1.000 1.000 530 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(3), BLVRA(1), COX10(5), COX15(4), CP(4), CPOX(5), EPRS(3), FECH(2), FTH1(1), FTMT(5), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UROD(1) 49076782 107 94 101 32 9 9 20 41 28 0 0.765 1.000 1.000 531 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(2), CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(3), ETS2(1), FOS(1), HOXA7(2), HRAS(1), IKBKB(3), JUN(2), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(3), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), RAF1(5), RELA(7), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRAF2(1) 57163113 113 94 107 30 13 8 7 43 41 1 0.735 1.000 1.000 532 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT2(1), CDS2(1), CHAT(5), CHKB(2), CHPT1(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), ESCO1(4), ESCO2(1), ETNK1(3), ETNK2(2), GPAM(5), GPD1(2), GPD1L(3), GPD2(2), LCAT(5), LYPLA1(1), PCYT1A(2), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PNPLA3(3), PPAP2B(2), PPAP2C(3), PTDSS1(2), PTDSS2(1), SH3GLB1(3) 77494873 110 92 106 28 15 16 12 31 36 0 0.260 1.000 1.000 533 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1), WASL(9) 60476650 107 92 106 45 10 21 20 32 24 0 0.963 1.000 1.000 534 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1), WASL(9) 60476650 107 92 106 45 10 21 20 32 24 0 0.963 1.000 1.000 535 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(8), AR(18), ESR2(5), HNF4A(3), NPM1(2), NR1D2(2), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(7), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(4), PPARD(1), PPARG(3), RARA(4), RARB(2), RARG(1), ROR1(1), RORA(4), RORC(2), RXRA(2), RXRB(5), RXRG(2), THRA(2), VDR(2) 48283073 99 91 91 29 11 15 18 40 15 0 0.458 1.000 1.000 536 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), AKT1(1), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), MAPK1(1), MAPK3(3), NR1I3(1), PAK1(4), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), RIPK3(1) 57683634 100 91 94 27 11 21 12 37 19 0 0.219 1.000 1.000 537 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), CYP19A1(2), HSD11B1(1), HSD11B2(1), HSD17B1(2), HSD17B2(1), HSD17B8(2), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6) 57945032 100 90 100 25 6 8 22 32 32 0 0.378 1.000 1.000 538 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(5), CARS(6), CARS2(3), DARS(4), DARS2(1), EPRS(3), FARSA(3), HARS(1), HARS2(1), IARS(4), IARS2(6), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), MTFMT(1), NARS2(6), PARS2(4), QARS(4), RARS(4), RARS2(2), SARS(2), TARS(6), TARS2(5), VARS(3), VARS2(6), WARS(1), WARS2(1), YARS(1), YARS2(1) 62976054 104 85 100 29 3 15 14 44 28 0 0.659 1.000 1.000 539 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(2), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GBGT1(3), GCNT2(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 56439467 104 85 98 29 11 17 10 32 33 1 0.569 1.000 1.000 540 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), DAO(1), GATM(2), GLUD1(1), GOT1(3), GOT2(3), MAOA(2), MAOB(3), NOS1(10), NOS3(3), OAT(3), ODC1(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(4), SMS(2) 52166213 93 84 91 23 9 6 17 28 33 0 0.446 1.000 1.000 541 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GAPDHS(4), GCK(1), GOT1(3), GOT2(3), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(1) 49444447 99 84 94 28 7 11 14 22 44 1 0.697 1.000 1.000 542 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(1), CDK2(2), CDT1(2), DIAPH2(3), MCM10(3), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), NACA(11), PCNA(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(2), RFC5(2), RPA1(2), RPA2(2), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(6) 59813784 98 83 89 26 10 13 11 34 30 0 0.439 1.000 1.000 543 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), CEL(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), GK(2), GLA(1), GLB1(5), LCT(5), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PPAP2B(2), PPAP2C(3) 57038692 98 83 95 27 14 13 11 30 30 0 0.355 1.000 1.000 544 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(1), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CPT1B(1), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), MAOA(2), MAOB(3), PISD(1), PLCB2(5), PLCG1(3), PLCG2(3), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6) 49604167 87 83 83 22 9 11 16 23 27 1 0.314 1.000 1.000 545 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(3), BCAR1(5), BCR(2), CAPN1(2), CSK(4), FYN(2), GRB2(3), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAPK1(1), MAPK3(3), PPP1R12B(3), PTK2(3), PXN(3), RAF1(5), RAP1A(1), ROCK1(7), SHC1(4), SOS1(7), SRC(2), TLN1(12), VCL(3), ZYX(1) 55077457 96 83 95 28 8 12 7 42 26 1 0.664 1.000 1.000 546 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(11), ASAH1(2), CAV3(1), DAG1(3), DLG4(1), EPHB2(3), GNAI1(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PITX2(2), RHO(1), RYR1(23) 53654839 88 83 88 24 14 12 13 32 17 0 0.282 1.000 1.000 547 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(8), AKR1B1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 54814918 94 82 90 25 6 10 17 22 37 2 0.627 1.000 1.000 548 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(1), CDC42(1), CFL1(1), CFL2(1), FLNA(5), FLNC(7), FSCN1(3), FSCN2(1), FSCN3(2), GDI2(2), LIMK1(6), MYH2(9), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PFN1(1), RHO(1), ROCK1(7), ROCK2(3), WASF1(1), WASL(9) 55427232 97 82 95 28 9 17 6 30 35 0 0.528 1.000 1.000 549 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(1), AKT2(4), AKT3(2), ARHGEF11(6), CDC42(1), DLG4(1), GNA13(6), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(6), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RDX(2), ROCK1(7), ROCK2(3), TBXA2R(4) 58459367 96 82 92 33 9 8 11 40 28 0 0.878 1.000 1.000 550 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1) 57205631 95 81 86 27 9 7 12 28 38 1 0.763 1.000 1.000 551 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1) 57205631 95 81 86 27 9 7 12 28 38 1 0.763 1.000 1.000 552 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MIOX(2), OCRL(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CA(16), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3) 53128384 91 81 84 28 6 15 9 33 28 0 0.758 1.000 1.000 553 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(8), CREBBP(13), EP300(16), ERCC3(3), GRIP1(5), GTF2A1(3), GTF2E1(1), GTF2F1(2), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), MEF2C(1), NCOR2(7), NRIP1(6), PELP1(1), POLR2A(11), TBP(2) 54844927 89 80 85 47 6 9 16 30 28 0 0.998 1.000 1.000 554 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPAT2(1), AGPS(2), CDS2(1), CHAT(5), CHKB(2), CLC(2), CPT1B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), ETNK1(3), GPD1(2), GPD2(2), LCAT(5), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PISD(1), PLA2G4A(2), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(3), PPAP2B(2), PPAP2C(3) 59037628 91 79 88 26 16 15 10 22 28 0 0.335 1.000 1.000 555 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(3), CAMK1G(4), ELK1(2), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NCF1(1), NCF2(2), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3C2G(5), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), RELA(7), SYT1(1) 45257365 92 78 86 25 10 10 8 30 33 1 0.707 1.000 1.000 556 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(3), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(2), LHCGR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NPY1R(2), NPY2R(3), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAC4(1), TACR1(1), TACR2(1), TACR3(2), TRHR(2), TSHR(3) 59524154 93 78 93 30 15 12 13 39 14 0 0.483 1.000 1.000 557 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(4), BTG1(3), CBX3(1), CLOCK(2), CRY1(1), EIF4G2(4), ETV6(2), HERPUD1(2), HSPA8(9), IDI1(1), KLF9(2), MYF6(5), NCKAP1(2), NCOA4(6), NR1D2(2), PER1(8), PER2(6), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), SUMO3(1), TOB1(4), UGP2(1), ZFR(7) 42750817 79 76 78 31 4 9 14 31 20 1 0.951 1.000 1.000 558 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), CALM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK14(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6) 44321389 85 75 82 25 9 11 10 29 26 0 0.702 1.000 1.000 559 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(2), F12(9), F13B(3), F2(4), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), LPA(9), PLAT(4), PLG(6), SERPINF2(2), VWF(15) 41598065 90 75 86 34 10 7 15 27 29 2 0.883 1.000 1.000 560 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CFLAR(3), DAXX(6), DFFA(1), DFFB(1), FAF1(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), PTPN13(10), RB1(4), RIPK2(2), SPTAN1(11) 49731360 85 72 85 27 5 6 16 28 28 2 0.790 1.000 1.000 561 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), ATF2(3), CALM2(1), EGFR(10), ELK1(2), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK1(1), MAPK3(3), MEF2A(2), MEF2C(1), MEF2D(1), PAK1(4), PRKCA(3), PTK2(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1) 39915866 78 70 76 22 8 14 9 28 19 0 0.487 1.000 1.000 562 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3B(3), POLR3E(1), POLR3H(2), POLR3K(1), TAF12(1), TAF5(2), TAF6(2), TAF7(2), TAF9(1), TBP(2) 41759952 77 70 73 26 3 9 9 25 31 0 0.833 1.000 1.000 563 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ACAT1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 43310811 76 69 73 20 5 8 13 21 28 1 0.586 1.000 1.000 564 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), B4GALT5(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), OGT(6), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(4) 38238278 72 68 69 26 5 7 12 29 19 0 0.892 1.000 1.000 565 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(1), DAXX(6), ELK1(2), GRB2(3), HRAS(1), HSPB2(3), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK14(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(2), RIPK1(2), RPS6KA5(3), SHC1(4), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 43430632 79 67 77 21 8 8 7 35 21 0 0.565 1.000 1.000 566 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), RB1(4), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 46308681 76 66 76 25 3 7 15 24 25 2 0.822 1.000 1.000 567 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(2), ADCY3(5), ADCY9(8), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), GNAS(5), PDIA4(2), PLCG1(3), PLCG2(3), PRKCA(3), SEC61B(1), TRIM23(3) 43700456 71 65 70 25 2 8 11 28 22 0 0.941 1.000 1.000 568 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(5), CXCR4(1), GNAI1(3), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), PIK3C2G(5), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PTK2B(4), PXN(3), RAF1(5), RELA(7) 32937718 72 64 62 27 5 16 5 25 19 2 0.931 1.000 1.000 569 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(2), AKT1(1), ASAH1(2), GNAI1(3), GNB1(3), ITGAV(2), ITGB3(4), MAPK1(1), MAPK3(3), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLCB1(3), PRKCA(3), PTK2(3), SMPD1(5), SMPD2(3), SPHK1(1), SRC(2) 32210770 68 64 60 23 10 17 4 21 16 0 0.686 1.000 1.000 570 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(2), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GANC(4), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH12(3), RDH13(1), UGP2(1) 44936912 72 63 71 22 7 10 8 24 23 0 0.703 1.000 1.000 571 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), BID(2), BIRC2(3), BIRC3(6), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DFFA(1), DFFB(1), GAS2(3), LMNA(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF10B(1), TNFSF10(9), TRADD(2), TRAF2(1) 39279854 70 62 64 18 1 8 13 23 24 1 0.482 1.000 1.000 572 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(4), ASAH1(2), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SGMS1(1), SGPP1(3), SMPD1(5), SMPD2(3), SMPD3(2), SMPD4(2), SPHK1(1), SPHK2(2), SPTLC1(3), SPTLC2(1), UGT8(1) 40831951 69 61 64 25 12 13 6 20 18 0 0.711 1.000 1.000 573 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CP(4), CPOX(5), EPRS(3), FECH(2), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UROD(1) 32302340 64 59 60 21 5 5 14 19 21 0 0.848 1.000 1.000 574 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(5), CALM2(1), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), PAK1(4), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1) 33410221 63 58 62 21 5 10 5 25 17 1 0.909 1.000 1.000 575 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), EPHB2(3), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(3), MAPK1(1), MAPK7(1), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RAF1(5), RASAL1(8), SRC(2), TEC(5), VAV1(6) 32263486 60 57 55 18 9 4 6 25 16 0 0.719 1.000 1.000 576 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(2), CDC42(1), CREB1(1), CREB5(3), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(2), IL1R1(3), MAP2K3(3), MAP3K10(4), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), MKNK1(2), MKNK2(2), NFKB1(1), NR2C2(1), TRAF6(2) 39499446 58 55 58 15 5 12 4 25 12 0 0.427 1.000 1.000 577 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(3), GTF2B(2), GTF2E1(1), GTF2F1(2), NCOA1(5), NCOA2(13), NCOA3(8), NCOR2(7), POLR2A(11), RARA(4), RXRA(2), TBP(2) 29423543 63 54 56 30 4 8 8 17 26 0 0.979 1.000 1.000 578 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(11), BAIAP2(3), CASP1(2), CASP7(1), CASP8(1), GAPDH(3), INS(1), INSR(4), ITCH(1), MAGI1(5), MAGI2(4), RERE(10), WWP1(7), WWP2(4) 27823305 57 53 47 23 7 2 7 19 19 3 0.997 1.000 1.000 579 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(1), GNAI1(3), GNB1(3), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), PLA2G4A(2), PLCB1(3), PRKCA(3), PTGS1(2), PTK2(3), RAF1(5), SRC(2), SYK(2), TBXAS1(4) 28684455 58 53 57 21 7 8 7 15 20 1 0.833 1.000 1.000 580 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(3), CAPN1(2), ITGA1(8), ITGB1(6), ITGB3(4), PTK2(3), PXN(3), SPTAN1(11), SRC(2), TLN1(12) 33627479 56 53 55 23 4 7 4 20 21 0 0.963 1.000 1.000 581 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSB(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), HSD11B1(1), HSD11B2(1), HSD17B2(1), HSD17B8(2), HSD3B1(1), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4) 31910844 56 52 56 17 3 4 12 15 22 0 0.630 1.000 1.000 582 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(2), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TLR10(3), TLR2(3), TLR3(2), TLR4(2), TLR6(2), TLR7(5), TLR9(1), TRAF6(2) 42857531 59 52 55 16 4 10 3 22 19 1 0.641 1.000 1.000 583 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(1), GNAS(5), GNB1(3), HRAS(1), LIMK1(6), MAPK1(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2(3), RAF1(5), ROCK2(3) 29986422 54 51 50 20 4 4 6 20 20 0 0.971 1.000 1.000 584 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(2), ALDOB(5), FPGT(1), GCK(1), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1), SORD(10), TPI1(1) 28227694 54 50 46 18 6 5 8 11 24 0 0.918 1.000 1.000 585 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(6), DARS(4), EPRS(3), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), QARS(4), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(1), YARS(1) 37940598 57 49 54 16 1 4 10 24 18 0 0.744 1.000 1.000 586 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKM(3), PFKP(3), PGM1(1) 37943653 54 48 53 22 4 8 5 15 22 0 0.968 1.000 1.000 587 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM2(1), CAPN2(3), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SYT1(1) 28178328 54 47 49 23 7 4 5 16 22 0 0.985 1.000 1.000 588 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(9), APOA1(1), CYP7A1(1), HMGCR(1), LCAT(5), LDLR(4), LIPC(1), LPL(6), LRP1(15), SCARB1(1), SOAT1(5) 31848173 49 47 47 15 5 8 5 16 15 0 0.576 1.000 1.000 589 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKL(3), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TALDO1(1), TKT(3), TKTL1(2), TKTL2(4) 28308157 48 46 45 15 5 10 7 11 15 0 0.681 1.000 1.000 590 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRA2A(1), ADRB2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), DRD1(1), DRD2(2), DRD3(3), DRD5(3), HRH2(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2) 29179700 49 45 47 23 8 4 3 21 13 0 0.937 1.000 1.000 591 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), BIRC2(3), BIRC3(6), CASP8(1), CFLAR(3), JUN(2), MAP3K3(3), MAP3K7(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(3), RIPK1(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 31902512 46 44 46 14 4 8 8 19 7 0 0.463 1.000 1.000 592 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), BCAR1(5), CSK(4), CTNNA1(9), CTNNA2(7), CTNNB1(4), PTK2(3), PXN(3), SRC(2), VCL(3) 22456638 44 42 44 21 5 5 6 18 9 1 0.973 1.000 1.000 593 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(8), DDX20(8), E2F1(1), ETS1(3), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(3), SIN3A(4), SIN3B(4) 30929306 46 42 45 16 7 5 3 19 12 0 0.723 1.000 1.000 594 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(1), ARSE(4), ASAH1(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SMPD1(5), SMPD2(3), SPTLC1(3), SPTLC2(1) 27802355 46 42 44 20 8 8 4 14 12 0 0.885 1.000 1.000 595 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(4), AP2M1(1), ARF1(1), EEA1(7), GRASP(1), GSK3A(1), GSK3B(3), LYN(3), PFKL(3), PFKM(3), PFKP(3), PLCG1(3), PRKCE(4), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4) 29563551 46 41 43 17 4 6 7 15 14 0 0.865 1.000 1.000 596 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), P4HB(2), SLC23A1(6), SLC23A2(2), SLC2A1(1), SLC2A3(2) 30108246 45 41 45 16 4 16 2 13 10 0 0.784 1.000 1.000 597 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(3), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SP1(2), SP3(3), SYT1(1) 23924009 44 39 41 16 4 5 5 9 20 1 0.940 1.000 1.000 598 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(6), GALNT2(2), GALNT4(4), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(4) 17269460 40 39 37 21 2 2 6 15 15 0 0.996 1.000 1.000 599 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TAL1(3), TALDO1(1), TKT(3) 23519618 42 39 39 14 3 8 7 10 14 0 0.806 1.000 1.000 600 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(2), CASP2(1), CHUK(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(3), MAP3K1(8), MAP4K2(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 28736215 43 39 40 12 2 5 4 16 15 1 0.809 1.000 1.000 601 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(4), AP2M1(1), BIN1(3), CALM2(1), DNM1(2), EPN1(1), EPS15(1), PICALM(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYNJ1(5), SYNJ2(6), SYT1(1) 26162782 38 38 38 13 1 6 7 14 10 0 0.734 1.000 1.000 602 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(2), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B1(1), HSD11B2(1), PLA2G4A(2), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(5), TBXAS1(4) 24838875 40 38 40 20 4 5 6 15 9 1 0.961 1.000 1.000 603 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(16), PIK3R1(5), PLCB1(3), PLCG1(3), PRKCA(3), VAV1(6) 15232773 37 35 30 12 5 12 3 8 9 0 0.565 1.000 1.000 604 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), AGPS(2), CHPT1(2), ENPP2(3), ENPP6(1), PAFAH1B1(2), PAFAH1B2(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PPAP2B(2), PPAP2C(3) 27618832 37 34 35 16 8 4 3 14 8 0 0.887 1.000 1.000 605 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(16), MAPK1(1), MAPK3(3), PELP1(1), SRC(2) 17397310 36 33 33 16 3 4 8 8 13 0 0.929 1.000 1.000 606 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), NPAS2(1), PER1(8), PER2(6), PER3(7) 19953118 32 32 30 13 4 1 6 12 9 0 0.896 1.000 1.000 607 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(6), JAK2(7), JAK3(4), PIAS3(3), PTPRU(6), SRC(2), STAT3(4) 17886898 36 32 36 11 2 5 5 14 10 0 0.755 1.000 1.000 608 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(7), JAK3(4), MAPK1(1), MAPK3(3), STAT3(4), TYK2(7) 13832210 32 32 31 11 3 1 8 11 9 0 0.863 1.000 1.000 609 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(5), FASN(8), MCAT(2), OLAH(2), OXSM(3) 18489296 28 28 28 11 3 4 4 11 6 0 0.762 1.000 1.000 610 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(3), B3GAT2(1), B3GAT3(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST3(2), CHST7(1), CHSY1(9), DSE(1), XYLT1(4), XYLT2(2) 15319635 30 28 24 11 5 6 1 7 11 0 0.819 1.000 1.000 611 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(2), GRM1(5), PLCB1(3), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 18749854 27 27 27 14 5 1 2 9 10 0 0.925 1.000 1.000 612 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(5), ITPKA(1), PDE1A(1), PDE1B(6), PLCB1(3), PLCB2(5), TRH(8) 12958568 29 27 22 13 6 2 1 6 14 0 0.979 1.000 1.000 613 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR1(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(3), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(3), VAMP1(2), VAMP2(1), VTI1A(1), VTI1B(1) 19768357 24 24 24 12 2 6 2 9 5 0 0.867 1.000 1.000 614 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(5), SRC(2), UBQLN1(3) 14487126 21 21 21 10 2 4 5 7 2 1 0.875 1.000 1.000 615 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(1) 9619204 19 19 17 10 1 1 3 10 4 0 0.962 1.000 1.000 616 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(3), CPOX(5), FECH(2), PPOX(3), UROD(1) 9096175 19 19 14 10 0 0 3 6 10 0 0.990 1.000 1.000