rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(3), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4) 6407869 17 17 16 0 3 3 6 5 0 0 0.00312 0.0139 1.000 2 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), KARS(1) 8277290 21 21 21 1 0 5 5 7 4 0 0.0264 0.0257 1.000 3 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(9), KARS(1) 5630342 15 15 15 1 0 3 4 5 3 0 0.0923 0.0401 1.000 4 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 605111 3 3 3 0 0 0 0 1 2 0 0.858 0.0540 1.000 5 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(3), GOT2(3), TAT(3), TYR(5) 5574296 17 17 17 2 3 1 3 4 6 0 0.255 0.0558 1.000 6 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(3), RANBP1(2), RANBP2(26), RANGAP1(1) 9694037 32 29 26 3 2 7 4 9 10 0 0.0261 0.0652 1.000 7 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(3), TAT(3) 3127345 9 9 9 1 2 1 2 0 4 0 0.339 0.0768 1.000 8 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), HLA-DRA(1), HLA-DRB1(6) 1493903 8 7 8 2 1 2 1 2 2 0 0.578 0.0801 1.000 9 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(3), EHHADH(6), HADHA(4) 5764259 14 14 13 1 1 3 5 3 2 0 0.0453 0.102 1.000 10 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(4), SHMT1(4), SHMT2(6) 4859216 14 14 14 2 2 1 3 4 4 0 0.226 0.104 1.000 11 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(2), PDXP(2), PSAT1(2) 5648478 14 14 14 1 3 1 1 6 3 0 0.147 0.104 1.000 12 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4) 9971050 22 22 21 1 1 4 6 8 3 0 0.00990 0.110 1.000 13 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(5) 2038596 7 7 7 2 1 1 0 4 1 0 0.687 0.211 1.000 14 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ECHS1(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(1) 9237301 20 20 17 1 2 4 5 4 5 0 0.0205 0.222 1.000 15 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(1), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(6), ITGB2(2), PRF1(1) 9870315 24 23 24 2 0 5 3 10 6 0 0.0538 0.229 1.000 16 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), GPD2(2), NDUFA1(1), SDHA(8), SDHB(1), SDHD(2), UQCRC1(2) 7707246 20 18 20 3 4 7 3 5 1 0 0.0813 0.240 1.000 17 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(2), RAB3A(3), RAB4A(1), RAB5A(1), RAB6A(2) 4994451 11 11 11 1 1 1 1 5 3 0 0.261 0.244 1.000 18 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(1) 1808576 4 4 4 1 0 0 0 2 2 0 0.815 0.265 1.000 19 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), RDH11(4), RDH12(3), RDH13(1) 5560033 12 12 12 1 1 1 1 8 1 0 0.203 0.315 1.000 20 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(7), EGF(5), EGFR(10), HGS(4), RAB5A(1), TF(1), TFRC(4) 15072760 32 31 30 3 5 1 6 9 11 0 0.0661 0.317 1.000 21 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CAMKK1(5), CAMKK2(3), CREB1(1), SYT1(1) 13707613 29 29 28 3 3 4 4 9 9 0 0.0645 0.350 1.000 22 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), ARF3(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), NXT1(1) 7926909 25 25 22 5 0 0 4 6 14 1 0.629 0.383 1.000 23 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 5 ARG1(2), ASL(4), CPS1(5), GLUD1(1), GOT1(3) 7765236 15 15 15 1 0 2 1 5 7 0 0.226 0.385 1.000 24 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(2) 1381597 3 3 3 0 0 0 1 1 1 0 0.585 0.387 1.000 25 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 5 ALDH4A1(2), ARG1(2), GLUD1(1), OAT(3), PRODH(2) 5255692 10 10 10 0 1 0 5 1 3 0 0.108 0.401 1.000 26 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL2(1), IL4(1) 3381396 11 10 11 3 2 2 2 3 2 0 0.532 0.405 1.000 27 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(1), NTAN1(1), SIRT1(5), SIRT5(1), SIRT7(5), VNN2(1) 14034028 29 28 28 3 4 5 7 6 7 0 0.0224 0.424 1.000 28 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(6), IL3(1) 3309864 9 8 9 2 0 2 2 2 3 0 0.526 0.439 1.000 29 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(3), HRAS(1), PTK2B(4), SHC1(4), SOS1(7), SRC(2) 10246089 22 20 22 2 1 7 1 8 5 0 0.0527 0.457 1.000 30 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(1), CD28(1), CD3E(1), CD3G(2) 2763125 5 5 5 0 1 0 1 2 1 0 0.351 0.460 1.000 31 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD2(2), CD34(2), CD3E(1), CD3G(2), CD58(1), CD8A(1), IL3(1), KITLG(2) 6296011 12 11 12 1 1 1 2 4 4 0 0.282 0.495 1.000 32 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL18(1), IL2(1) 3598832 6 6 6 1 0 1 0 3 2 0 0.706 0.504 1.000 33 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(3), MDH1(1), ME1(1), PC(8), PDHA1(1), SLC25A11(4) 10818832 28 27 28 4 2 3 1 13 9 0 0.155 0.517 1.000 34 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 9 ACACA(8), CPT1A(3), LEP(1), LEPR(5), PRKAA1(2), PRKAB1(1), PRKAG1(6), PRKAG2(7) 15875894 33 32 33 4 2 5 9 9 8 0 0.0250 0.518 1.000 35 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(9), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(5), NOS3(3), REN(1) 11439822 26 25 24 3 3 3 3 10 7 0 0.0826 0.522 1.000 36 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 855604 1 1 1 0 0 0 1 0 0 0 0.752 0.528 1.000 37 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(2), DHRS2(1), PON1(1), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1) 9758428 19 19 18 2 2 1 3 10 3 0 0.185 0.558 1.000 38 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 GBA(2), GGT1(4), SHMT1(4), SHMT2(6) 5818626 16 16 16 4 2 1 3 5 5 0 0.480 0.560 1.000 39 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(4), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL6(2), FADS1(1), FADS2(2), FASN(8), HADHA(4), PECR(3) 16091585 32 28 32 3 4 8 2 15 3 0 0.00668 0.572 1.000 40 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(2), BMPR1B(1), BMPR2(6) 7309172 14 12 14 0 0 2 3 6 3 0 0.0140 0.574 1.000 41 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT2(4), AKT3(2), CDKN1A(3), ELK1(2), GRB2(3), HRAS(1), MAP2K2(1), NGFR(2), NTRK1(6), PIK3CD(2), SHC1(4), SOS1(7) 16208446 38 37 37 5 3 8 2 17 7 1 0.0272 0.597 1.000 42 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(2) 10223639 19 19 18 2 1 1 2 4 9 2 0.254 0.610 1.000 43 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(6), ENO2(2), ENO3(2), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1) 9835583 25 22 25 4 3 3 5 5 9 0 0.183 0.617 1.000 44 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), APEX1(1), CREBBP(13), DFFA(1), DFFB(1), HMGB2(3), PRF1(1) 12367922 23 22 23 3 4 3 7 4 5 0 0.0449 0.618 1.000 45 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(6), AKT1(1), ATM(23), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIC1(1), HIF1A(5), HSPA1A(1), IGFBP3(1), NFKBIB(2) 23701502 53 48 49 6 3 6 6 16 20 2 0.0452 0.632 1.000 46 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(2), CDC25B(1), CDC25C(4), MNAT1(1), SHH(3), XPO1(7) 10285303 19 19 19 3 2 2 7 6 2 0 0.142 0.638 1.000 47 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(1), MECR(4), PPT1(1) 10002336 18 17 18 2 2 3 5 7 1 0 0.0854 0.654 1.000 48 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(1), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(2) 10290722 22 22 19 3 1 2 2 4 11 2 0.240 0.655 1.000 49 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 3 GLS2(4), GLUD1(1), GLUD2(1) 3875938 6 6 6 0 1 0 0 4 1 0 0.353 0.688 1.000 50 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), FOS(1), GRB2(3), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4) 20797857 50 47 49 6 6 4 8 19 13 0 0.0376 0.694 1.000 51 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(4), WEE1(2) 8729131 13 12 13 1 1 2 0 6 3 1 0.226 0.701 1.000 52 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(2), OXCT1(2) 4036194 5 5 5 1 0 1 0 2 2 0 0.588 0.703 1.000 53 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(2), PRKAB1(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAR1A(3), PRKAR2B(4) 16615694 39 39 39 5 4 4 5 16 10 0 0.0585 0.703 1.000 54 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(2), ALDOB(5), TPI1(1) 4573571 9 9 8 4 0 0 2 1 6 0 0.979 0.703 1.000 55 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(6), CASP8(1), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 9529683 17 17 17 3 0 4 5 6 2 0 0.270 0.714 1.000 56 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(6), GPI(3), HK1(7), PFKL(3), PGK1(3), PKLR(1), TPI1(1) 10653480 29 28 26 5 5 3 2 6 13 0 0.212 0.715 1.000 57 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), FPGS(4), GGH(3) 7426369 23 21 23 6 4 5 3 7 4 0 0.269 0.721 1.000 58 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT2(4), AKT3(2), BPNT1(3), GRB2(3), ILK(4), MAPK1(1), MAPK3(3), PDK1(1), PIK3CD(2), PTK2B(4), RBL2(3), SHC1(4), SOS1(7) 20300439 42 38 40 4 5 8 5 12 12 0 0.00929 0.728 1.000 59 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS1(2), SPCS3(1) 3645746 5 5 5 1 0 0 1 2 2 0 0.669 0.729 1.000 60 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1) 12471261 26 24 26 4 1 4 3 11 7 0 0.255 0.745 1.000 61 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(2), GOT1(3), GOT2(3), LDHB(1), LDHC(3), MPST(2) 7991957 20 20 18 4 1 0 2 6 11 0 0.710 0.745 1.000 62 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CCL2(1), LDLR(4), LPL(6) 6181145 12 12 12 3 1 3 0 4 4 0 0.474 0.749 1.000 63 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(1) 1923861 2 2 2 1 0 0 1 1 0 0 0.874 0.754 1.000 64 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CBL(2), CSF1R(8), EGF(5), EGFR(10), GRB2(3), PDGFRA(6), PRKCA(3), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(2) 19602507 46 42 44 6 5 7 6 14 14 0 0.0595 0.763 1.000 65 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 1942941 2 2 2 0 0 0 0 2 0 0 0.702 0.764 1.000 66 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(3), ITGAL(6), ITGAM(9), ITGB2(2), SELE(5), SELL(2) 12488509 30 30 30 5 0 9 5 9 7 0 0.0961 0.766 1.000 67 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(5), PPP1R1B(1) 4332827 7 7 7 2 1 1 1 3 1 0 0.596 0.774 1.000 68 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(3) 4537325 5 5 5 1 0 0 3 1 1 0 0.588 0.779 1.000 69 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(6), JAK2(7), STAT1(6) 9770238 26 26 26 5 3 0 3 11 9 0 0.495 0.785 1.000 70 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(2), GREB1(18), HSPB2(3), MTA1(7), MTA3(4), PDZK1(1), TUBA8(1) 12679545 38 35 36 8 1 5 9 15 8 0 0.355 0.803 1.000 71 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(3), WT1(3) 7253503 16 16 16 4 0 1 1 7 7 0 0.736 0.806 1.000 72 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(7), CCNA2(1), CCNE1(1), CCNE2(4), CDK2(2), CDK4(7), CDKN1B(1), CDKN2A(4), E2F1(1), E2F2(1) 9711014 29 25 22 6 0 3 4 3 19 0 0.479 0.808 1.000 73 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(6), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5) 6209152 15 15 15 4 2 2 1 6 3 1 0.585 0.811 1.000 74 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(1), HMGB1(2), HMGB2(3), TOP2A(5), TOP2B(3) 11885764 16 15 16 1 3 2 2 3 5 1 0.116 0.814 1.000 75 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 6 FOS(1), FYN(2), JUN(2), MAPK14(2) 5693618 7 7 7 1 1 1 0 5 0 0 0.477 0.818 1.000 76 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE3A(4) 12356359 18 18 18 2 2 2 2 8 4 0 0.159 0.822 1.000 77 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(2), CD28(1), CD3E(1), CD3G(2), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1) 12092842 25 24 25 4 1 3 3 11 7 0 0.322 0.824 1.000 78 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB1(6), ABCB11(4), ABCB4(7), ABCC3(10) 13507645 27 26 24 4 0 5 6 9 7 0 0.142 0.830 1.000 79 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDK2(2), CUL1(5), E2F1(1), FBXW7(5), RB1(4) 9994649 18 18 18 3 1 1 3 3 8 2 0.423 0.831 1.000 80 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(7), ZAP70(1) 9301049 21 19 21 4 1 3 2 10 5 0 0.445 0.833 1.000 81 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(8), POLG(6), PRPS2(4), RRM1(4) 14678780 30 29 28 4 2 5 2 10 11 0 0.118 0.836 1.000 82 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(3), TIMP1(1), TIMP2(1) 8437163 14 14 14 3 2 2 1 6 3 0 0.486 0.855 1.000 83 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 2655701 3 3 3 1 0 0 1 0 2 0 0.902 0.866 1.000 84 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 2388047 2 2 2 1 0 0 0 1 1 0 0.774 0.872 1.000 85 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(2), EGF(5), EGFR(10), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), PTPRB(7), RAF1(5), RASA1(7), SHC1(4), SOS1(7), SPRY1(2), SPRY2(3), SRC(2) 28863871 62 56 60 8 5 14 10 19 14 0 0.0112 0.874 1.000 86 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(5), GNB1(3), PRKACA(1), PRKAR1A(3) 7532310 14 14 14 3 1 1 1 10 1 0 0.646 0.878 1.000 87 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 8 ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1) 8855967 14 14 14 3 2 2 3 4 3 0 0.395 0.882 1.000 88 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG12(1), ATG3(1), ATG7(7), BECN1(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNG(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(2), ULK1(2), ULK2(3), ULK3(4) 23684924 48 46 48 7 4 3 4 27 10 0 0.127 0.884 1.000 89 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(2) 2459780 7 7 7 3 0 2 1 2 2 0 0.875 0.890 1.000 90 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(2), FUT2(1), GCNT2(5), ST8SIA1(2) 7006778 10 10 10 2 2 1 1 5 1 0 0.352 0.891 1.000 91 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(1), NFKB1(1), NOX1(7), RELA(7), TNF(1), XDH(7) 11669608 26 23 21 4 1 2 6 4 12 1 0.490 0.903 1.000 92 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(7), AMT(1), ATIC(3), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6) 21171181 41 40 41 6 4 7 5 16 9 0 0.0473 0.910 1.000 93 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), FDXR(3), SHMT1(4) 18945268 42 40 42 7 3 3 11 15 9 1 0.153 0.912 1.000 94 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(3), GAD1(2), GAD2(3), GGT1(4) 6718975 14 14 14 4 1 1 5 3 4 0 0.506 0.916 1.000 95 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(5), ACSS1(3), ACSS2(8), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SUCLA2(2) 15749565 40 33 36 7 2 6 3 11 17 1 0.229 0.917 1.000 96 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), KERA(2), LUM(1) 4205580 9 9 9 3 0 1 0 5 3 0 0.674 0.920 1.000 97 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(4), ATM(23), BAX(1), CCNE1(1), CDK2(2), CDK4(7), CDKN1A(3), E2F1(1), PCNA(3), RB1(4) 20038465 49 43 45 8 2 4 6 11 23 3 0.277 0.920 1.000 98 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(3), HLA-A(6), IL18(1), ITGB1(6), KLRC1(2), KLRC2(3), KLRC3(2), MAPK3(3), PAK1(4), PIK3R1(5), PTK2B(4), PTPN6(3), SYK(2), VAV1(6) 19523079 50 44 49 9 4 8 5 14 18 1 0.253 0.924 1.000 99 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(3), JAK1(6), JAK2(7), PTPRU(6), STAT1(6) 13450707 32 30 32 6 4 0 3 17 8 0 0.435 0.924 1.000 100 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(3), MTMR6(1), NFS1(1), PHPT1(1), THTPA(1), TPK1(1) 7567533 10 10 10 2 1 1 2 6 0 0 0.431 0.929 1.000 101 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(2), EIF2S2(2), NFKB1(1), NFKBIA(1), RELA(7) 10772393 15 15 12 2 0 4 0 3 7 1 0.413 0.934 1.000 102 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2) 10577915 20 19 17 4 1 3 1 6 9 0 0.404 0.935 1.000 103 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM7(5), GRM8(3) 23436178 55 48 52 9 7 8 6 23 11 0 0.0741 0.941 1.000 104 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), HMGCS1(4), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1) 15535886 23 21 23 2 0 3 3 10 7 0 0.0972 0.941 1.000 105 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(5), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4) 20706338 48 44 48 9 3 7 12 12 14 0 0.176 0.942 1.000 106 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(10), ERBB3(7), NRG1(4), UBE2D1(2) 12128567 28 28 26 5 4 2 3 9 10 0 0.258 0.942 1.000 107 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH1(1), BDH2(1), HMGCL(2), HMGCS1(4), HMGCS2(3), OXCT1(2) 8734560 14 14 14 3 0 2 1 6 5 0 0.542 0.943 1.000 108 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(4), F2R(2), F5(11), F7(1), FGA(4), FGB(3), FGG(6), PROC(3), PROS1(5), TFPI(1) 19277211 41 39 39 7 6 3 3 14 14 1 0.168 0.946 1.000 109 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), PC(8), PCK1(9), SDHA(8), SDHB(1), SUCLA2(2), SUCLG1(6), SUCLG2(2) 24274091 64 58 61 12 3 9 9 21 21 1 0.132 0.947 1.000 110 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(11), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 14986154 33 32 33 6 8 3 5 10 7 0 0.0967 0.948 1.000 111 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1) 11899140 19 17 19 3 2 3 3 5 6 0 0.251 0.949 1.000 112 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(2), STX1A(1), VAMP2(1) 3774022 6 5 6 3 0 1 0 2 3 0 0.920 0.954 1.000 113 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 114 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 115 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4) 17916958 39 37 39 7 3 2 11 13 9 1 0.221 0.957 1.000 116 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST8SIA1(2) 12352485 21 20 21 4 3 3 2 10 3 0 0.211 0.958 1.000 117 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(1), CES1(8), ESD(1) 6899681 15 15 13 4 0 3 2 5 5 0 0.502 0.961 1.000 118 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(2), CBS(1), CTH(2), MUT(2) 5726813 7 7 7 2 1 0 1 1 4 0 0.842 0.961 1.000 119 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCR3(1), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(1) 5006667 11 10 11 4 0 3 3 2 3 0 0.778 0.962 1.000 120 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), SELE(5), SELL(2), SELP(2) 19016965 41 39 41 8 0 11 8 12 10 0 0.138 0.963 1.000 121 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 11 ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4) 13172421 25 25 24 5 3 4 7 8 3 0 0.154 0.964 1.000 122 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELE(5), SELL(2) 14368468 30 29 30 6 0 9 6 7 8 0 0.197 0.966 1.000 123 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(3), HSD17B1(2), HSD17B2(1), HSD17B4(1), HSD3B1(1) 9508316 10 10 10 2 2 3 2 2 1 0 0.328 0.967 1.000 124 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(2) 5140988 6 6 6 2 1 0 0 2 3 0 0.849 0.968 1.000 125 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(3), UGDH(1), UXS1(1) 4707481 5 5 5 2 0 1 3 1 0 0 0.717 0.970 1.000 126 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(11), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7) 18530781 41 38 41 8 3 6 3 17 12 0 0.352 0.974 1.000 127 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(2), ENPP1(2), ENPP3(2), FLAD1(5), TYR(5) 11396461 19 19 19 4 0 4 0 10 5 0 0.539 0.975 1.000 128 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(3) 4531700 5 5 5 2 0 0 2 2 1 0 0.810 0.975 1.000 129 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(1), CTH(2), GGT1(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1) 14397996 30 29 30 6 3 3 7 8 9 0 0.300 0.976 1.000 130 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(11), NRG2(3), NRG3(5), PRKCA(3), PSEN1(1) 10732996 26 26 26 6 2 5 3 11 5 0 0.398 0.976 1.000 131 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(4), LDLR(4), MBTPS1(4), MBTPS2(2), SCAP(3), SREBF1(4), SREBF2(11) 13962967 32 32 32 7 3 4 6 8 11 0 0.336 0.977 1.000 132 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(5), ARHGDIB(1), CASP1(2), CASP10(3), CASP8(1), CASP9(2), JUN(2), PRF1(1) 14949157 21 20 21 3 0 4 1 7 9 0 0.367 0.977 1.000 133 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(2), CDC25B(1), CDC25C(4), CSK(4), GRB2(3), PRKCA(3), PTPRA(5), SRC(2) 10889531 24 22 24 5 1 7 4 8 4 0 0.228 0.977 1.000 134 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(3), UGDH(1), UGP2(1), UXS1(1) 5951897 6 6 6 2 0 1 4 1 0 0 0.603 0.978 1.000 135 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), VKORC1(1) 13028401 16 16 16 2 0 1 3 7 5 0 0.258 0.978 1.000 136 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(3), FGG(6), PLAT(4), PLG(6) 15878389 38 35 33 8 6 2 5 14 11 0 0.275 0.978 1.000 137 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(1), GLI2(4), GLI3(7), GSK3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SHH(3), SMO(5), SUFU(3) 18844457 42 40 40 8 5 6 5 15 11 0 0.154 0.979 1.000 138 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(3), FH(2), IDH2(6), MDH1(1), OGDH(8), SDHA(8), SUCLA2(2) 11153169 30 27 27 7 1 8 0 11 10 0 0.411 0.980 1.000 139 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(3), ITPKA(1), ITPKB(3) 6806857 9 8 9 4 1 1 2 0 5 0 0.915 0.983 1.000 140 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(7), IL3(1), IL9(1), KITLG(2), TGFB2(2) 9890437 14 14 14 3 0 1 3 5 5 0 0.623 0.984 1.000 141 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(5), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(2) 7827104 14 14 12 4 2 2 1 3 6 0 0.723 0.984 1.000 142 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CHEK1(1), MYT1(9), WEE1(2) 16378588 42 38 41 9 3 10 5 14 10 0 0.228 0.984 1.000 143 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYC(3), RB1(4), SP1(2), SP3(3) 7958528 15 15 15 5 0 3 1 4 5 2 0.843 0.984 1.000 144 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), HSPA1A(1), IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(1), NFKBIA(1), RB1(4), RELA(7), TNF(1), TNFRSF1A(1), TNFRSF1B(2), USH1C(4), WT1(3) 20886407 45 42 42 9 1 4 3 13 21 3 0.640 0.985 1.000 145 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(7), AMT(1), ATIC(3), FTCD(3), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6) 22501622 45 44 45 9 4 7 5 20 9 0 0.180 0.985 1.000 146 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(2), HDC(1), TH(4), TPH1(3) 6893106 12 12 12 4 2 2 4 2 2 0 0.633 0.985 1.000 147 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3) 8206577 12 12 12 4 2 1 3 5 1 0 0.635 0.986 1.000 148 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3) 8206577 12 12 12 4 2 1 3 5 1 0 0.635 0.986 1.000 149 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(3), PAPSS1(3), PAPSS2(4), SULT2A1(1), SUOX(5) 8504618 16 15 16 4 1 1 4 3 7 0 0.601 0.986 1.000 150 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(7), C6(3), C7(4), C8A(3), C9(1) 15081835 27 27 27 5 2 5 3 13 4 0 0.219 0.986 1.000 151 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(3), EPHB1(3), FYN(2), ITGA1(8), ITGB1(6), L1CAM(5), LYN(3), SELP(2) 18462940 33 31 32 5 4 4 2 13 10 0 0.164 0.987 1.000 152 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), IDS(2), IDUA(2), LCT(5), NAGLU(3) 16997409 38 33 38 8 4 6 5 11 12 0 0.199 0.987 1.000 153 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(1), HSD3B1(1) 7999811 10 10 10 3 1 0 1 7 1 0 0.614 0.987 1.000 154 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), E2F1(1), RB1(4) 18790173 37 33 31 9 2 1 4 7 20 3 0.623 0.987 1.000 155 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(5), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HMGCR(1), IDI1(1), IDI2(2), LSS(4), MVK(1), NSDHL(3), PMVK(1), TM7SF2(3), VKORC1(1) 22729691 33 31 31 3 1 3 2 15 12 0 0.0856 0.988 1.000 156 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(6), NR3C1(4), PPARG(3), RETN(1), RXRA(2), TNF(1) 6617286 18 17 18 6 2 6 1 3 6 0 0.637 0.988 1.000 157 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RELA(7) 9734433 15 15 12 7 1 3 0 1 9 1 0.978 0.988 1.000 158 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(3), EXT2(3), EXTL1(2), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), NDST1(3), NDST2(4), NDST4(9) 23382679 45 42 44 7 5 9 4 13 14 0 0.0725 0.989 1.000 159 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1) 3860292 4 4 4 2 0 0 0 2 2 0 0.955 0.989 1.000 160 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15B(4), ALOX5(4), DPEP1(2), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 17900650 41 37 39 8 5 5 8 11 11 1 0.200 0.989 1.000 161 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(1), CCNE1(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3R1(5), RAF1(5), RB1(4), RELA(7) 21263177 49 41 43 8 4 4 6 11 20 4 0.370 0.990 1.000 162 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1) 8292640 21 21 21 6 0 1 3 10 7 0 0.720 0.990 1.000 163 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(4), NFATC2(6), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 13579389 34 32 32 8 6 1 3 13 11 0 0.398 0.991 1.000 164 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), IFNG(2), IL2(1), IL2RA(2), IL4(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), TOB1(4), TOB2(3) 12598947 24 24 24 5 1 2 6 8 7 0 0.352 0.991 1.000 165 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1) 27630715 58 53 56 9 4 9 5 22 18 0 0.0652 0.992 1.000 166 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(3) 5762026 6 6 6 2 0 1 0 1 4 0 0.914 0.994 1.000 167 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(4) 15582305 28 28 28 5 1 2 3 14 8 0 0.440 0.994 1.000 168 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(2), BRAF(6), CREB1(1), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(2), EIF4E(2), GRB2(3), MAP2K2(1), MAP3K8(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MOS(1), NFKB1(1), RAP1A(1), RPS6KA3(2), SHC1(4), SOS1(7), SOS2(7), TRAF3(1) 33094442 58 55 57 9 6 10 11 20 10 1 0.0288 0.994 1.000 169 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1) 10116055 16 16 16 4 0 1 1 9 5 0 0.798 0.994 1.000 170 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT3(2), FUT5(1), FUT6(4), ST3GAL3(3) 5583180 11 10 9 4 4 2 0 2 3 0 0.708 0.994 1.000 171 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 29 AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADHA(4), PLOD1(3), PLOD2(7), SHMT1(4), SHMT2(6), TMLHE(1) 39807708 93 83 89 15 10 16 15 29 23 0 0.00677 0.995 1.000 172 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD8A(1), IL2(1), IL3(1), IL4(1), IL9(1) 6044911 5 5 5 2 0 1 2 1 1 0 0.764 0.995 1.000 173 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNB1(2), JAK1(6), STAT1(6), STAT2(7), TYK2(7) 12734329 32 27 31 8 4 5 4 7 12 0 0.328 0.995 1.000 174 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(2), NFKB1(1), RELA(7), TNFRSF13B(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2) 17056100 22 21 19 3 0 5 0 7 9 1 0.368 0.995 1.000 175 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5) 15575333 34 33 32 7 2 4 6 9 13 0 0.331 0.996 1.000 176 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(20), MAP2(5), PPP2CA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4), PRKCE(4) 21093846 45 41 42 8 5 4 4 16 15 1 0.179 0.996 1.000 177 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3) 6673482 11 11 10 5 1 0 0 7 3 0 0.931 0.996 1.000 178 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADSYN1(1), NMNAT2(3), NNMT(1), NNT(9), NT5C(1), NT5M(3), QPRT(1) 17203425 32 32 32 7 3 4 3 17 5 0 0.330 0.996 1.000 179 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(3), EPOR(1), GRIN1(2), HIF1A(5), JAK2(7), NFKB1(1), NFKBIA(1), RELA(7) 14984819 29 27 26 6 0 4 4 8 10 3 0.519 0.996 1.000 180 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(1), ACP2(2), ACP5(2), ACP6(1), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CMBL(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), PON1(1), PON2(2), PON3(5) 20296633 39 37 38 8 4 7 3 14 11 0 0.267 0.996 1.000 181 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), CD80(1), CD86(3), CTLA4(1), GRB2(3), HLA-DRA(1), HLA-DRB1(6), ICOS(3), IL2(1), ITK(2), LCK(1), PIK3R1(5), PTPN11(1) 12334521 32 31 31 7 4 5 2 11 10 0 0.567 0.996 1.000 182 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12) 19491005 38 35 36 5 3 3 2 14 16 0 0.158 0.996 1.000 183 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(4), SNCAIP(5), UBE2E2(1), UBE2L3(1) 7467277 16 16 16 5 1 4 2 6 3 0 0.588 0.996 1.000 184 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3) 16676977 23 20 23 3 1 2 6 8 6 0 0.190 0.997 1.000 185 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(3), IL10RA(3), IL10RB(1), JAK1(6), STAT1(6), STAT3(4), STAT5A(4), TNF(1) 14310346 29 29 28 6 4 1 1 11 12 0 0.686 0.997 1.000 186 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(2), JAK1(6), PTPRU(6), STAT1(6), STAT2(7), TYK2(7) 14548500 37 32 36 9 5 4 4 12 12 0 0.317 0.997 1.000 187 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(11), AXIN1(5), BTRC(4), CTNNB1(4), DLL1(1), DVL1(1), FZD1(2), GSK3B(3), NOTCH1(9), PSEN1(1), WNT1(2) 24213001 46 44 43 7 4 5 3 22 11 1 0.108 0.997 1.000 188 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 9064046 17 16 16 8 1 0 2 5 9 0 0.984 0.997 1.000 189 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(3), IL4(1), IL4R(5), IRS1(6), JAK1(6), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(4) 16903039 36 34 36 8 6 3 6 12 9 0 0.306 0.997 1.000 190 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 15 C1QA(1), C1R(4), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1), MASP1(5), MASP2(2), MBL2(2) 31204828 47 46 45 6 6 9 5 19 7 1 0.0181 0.997 1.000 191 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), EIF4E(2), IFNG(2), IFRD1(1), IL18(1), IL1R1(3), NR4A3(2), WDR1(1) 12784417 17 17 17 4 1 3 3 5 5 0 0.502 0.997 1.000 192 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(6), FYN(2), LRP8(6), RELN(8), VLDLR(3) 16515271 25 24 20 4 1 5 1 7 11 0 0.525 0.998 1.000 193 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(2), ACAA1(4), ACADM(3), ACADS(3), ACAT1(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(1), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4) 50196146 90 87 88 11 7 9 19 35 19 1 0.00252 0.998 1.000 194 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(3), CHST11(1), CHST12(2), CHST13(1), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT2A1(1), SUOX(5) 11817656 22 21 21 5 3 2 5 3 9 0 0.523 0.998 1.000 195 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 8 ALAS1(5), ALAS2(3), FECH(2), PPOX(3), UROD(1) 8239687 14 14 13 8 0 0 3 6 5 0 0.960 0.998 1.000 196 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7) 12218455 27 26 26 9 3 0 6 8 10 0 0.829 0.998 1.000 197 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7) 12218455 27 26 26 9 3 0 6 8 10 0 0.829 0.998 1.000 198 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 9 ADH5(1), CAT(3), EPX(2), LPO(2), MTHFR(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4) 11939887 26 25 26 6 1 3 5 9 8 0 0.480 0.998 1.000 199 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 19004529 39 36 39 8 3 8 2 16 10 0 0.153 0.998 1.000 200 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 12 C1QA(1), C1R(4), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1) 26637380 38 37 36 5 4 7 4 16 6 1 0.0458 0.998 1.000 201 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4) 41549917 79 77 77 12 6 10 18 30 15 0 0.0143 0.999 1.000 202 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(4), ABAT(2), ADSL(2), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), CRAT(2), DARS(4), DDO(1), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), PC(8) 25291037 50 47 50 9 1 6 10 11 22 0 0.213 0.999 1.000 203 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), PANK1(4), PANK2(5), PANK3(2), PANK4(1), UPB1(2) 16311597 29 28 29 7 3 3 5 9 9 0 0.379 0.999 1.000 204 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2), COQ6(1), COQ7(1), NDUFA13(2) 4897379 7 7 7 4 3 1 0 2 1 0 0.864 0.999 1.000 205 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 15129445 28 28 28 7 4 3 3 14 4 0 0.414 0.999 1.000 206 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(5), CALCRL(3), CD97(7), CRHR1(2), CRHR2(4), ELTD1(4), EMR1(2), EMR2(3), GIPR(2), GLP1R(3), GLP2R(5), GPR64(2), LPHN1(6), LPHN2(4), LPHN3(11), SCTR(1), VIPR1(1), VIPR2(1) 32308051 68 61 66 12 10 8 11 26 12 1 0.0301 0.999 1.000 207 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(4), NR1H3(2), NR1H4(2), RXRA(2) 6175692 10 10 10 4 0 4 0 3 3 0 0.724 0.999 1.000 208 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(5), CLYBL(3), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), OGDHL(3), PC(8), PCK1(9), PCK2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 35143242 92 79 89 18 6 14 10 32 29 1 0.100 0.999 1.000 209 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 15869680 28 28 28 7 4 3 3 14 4 0 0.414 0.999 1.000 210 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(3), HTR2C(1), PLCB1(3), TUB(3) 8368268 12 11 12 4 1 2 0 7 2 0 0.696 0.999 1.000 211 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(6), CREB1(1), CREB5(3), MAPK1(1), RAF1(5), SNX13(3), SRC(2), TERF2IP(1) 13595024 26 22 25 6 1 6 4 9 5 1 0.359 0.999 1.000 212 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 14 C1QA(1), C1R(4), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C8B(2), C9(1), MASP1(5) 30533019 45 44 43 6 7 8 4 18 7 1 0.0271 0.999 1.000 213 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(5), GNB1(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3) 11260408 25 24 25 6 3 3 1 12 6 0 0.567 0.999 1.000 214 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(3), SULT1C4(5), SULT4A1(1) 14776777 33 33 31 9 2 2 5 10 14 0 0.812 0.999 1.000 215 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(5), AOC3(1), CES1(8), DDHD1(3), ESCO1(4), ESCO2(1), LIPA(1), PLA1A(4), PNPLA3(3), PRDX6(2), SH3GLB1(3) 29648540 36 34 34 3 1 6 3 12 14 0 0.0413 0.999 1.000 216 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(1), ACOT11(2), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), FN3K(1), GCDH(5), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 29686882 36 36 33 4 2 7 6 8 13 0 0.0685 0.999 1.000 217 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(9), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2) 15603561 27 25 25 5 2 7 4 6 8 0 0.257 0.999 1.000 218 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(3), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1), YARS2(1) 10272578 19 18 19 5 2 2 3 5 7 0 0.686 0.999 1.000 219 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 12 ADH5(1), CAT(3), EPX(2), LPO(2), PRDX1(1), PRDX5(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4) 12201195 27 26 27 7 1 4 5 9 8 0 0.530 0.999 1.000 220 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(5), PPP2CA(1) 11058258 14 14 12 7 0 1 2 2 9 0 0.957 0.999 1.000 221 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 14 ACADL(3), ACADM(3), ACADS(3), ACSL1(2), ACSL4(1), CPT1A(3), CPT2(2), EHHADH(6), HADHA(4), PECR(3), SCP2(3) 18112378 33 32 31 8 2 8 10 10 3 0 0.138 0.999 1.000 222 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 6 EPX(2), GBA(2), LPO(2), PRDX6(2), TPO(4) 8153261 12 11 12 5 0 2 2 3 5 0 0.865 0.999 1.000 223 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4) 11829678 23 23 23 6 3 3 5 8 4 0 0.397 0.999 1.000 224 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(3), BIRC3(6), CASP10(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(3), SREBF1(4), SREBF2(11) 21330582 41 39 41 8 2 7 6 13 13 0 0.189 1.000 1.000 225 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 24 ABAT(2), ACADM(3), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2) 30360604 59 57 58 11 4 7 15 17 15 1 0.0487 1.000 1.000 226 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(2), ACP6(1), ENPP1(2), ENPP3(2), FLAD1(5), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5) 17715684 27 26 27 5 0 5 1 16 5 0 0.378 1.000 1.000 227 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SLC2A4(3), SOS1(7) 26890340 58 54 56 11 9 12 7 19 11 0 0.0977 1.000 1.000 228 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CDK2(2), CDK4(7), CHEK1(1), MYT1(9), RB1(4), WEE1(2) 20007629 55 49 51 11 3 10 8 15 17 2 0.220 1.000 1.000 229 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT2(1), FUT3(2), ST3GAL3(3), ST3GAL4(2) 8269899 15 14 13 6 5 0 2 2 6 0 0.846 1.000 1.000 230 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(6), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(6), SOAT1(5) 16243447 38 33 36 9 2 2 8 15 11 0 0.427 1.000 1.000 231 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(7), KHK(5), LCT(5), MPI(2), PGM1(1), PYGL(1), PYGM(4), TPI1(1) 15986360 26 25 26 6 5 2 4 9 6 0 0.308 1.000 1.000 232 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(1), GPR171(1), GPR18(2), GPR34(1), GPR39(2), GPR45(3), GPR65(5), GPR75(1) 11457683 17 17 17 5 3 3 0 8 2 1 0.410 1.000 1.000 233 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(2), IFNG(2), IKBKB(3), IL2(1), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TNFRSF9(1), TNFSF9(1), TRAF2(1) 23191235 45 38 42 8 1 4 1 19 19 1 0.528 1.000 1.000 234 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(4) 7893439 12 12 11 6 1 3 1 2 5 0 0.932 1.000 1.000 235 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), PER1(8) 9954612 18 18 17 5 2 0 3 7 6 0 0.650 1.000 1.000 236 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(5), PLCE1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAP2B(2) 17159196 28 28 28 6 3 4 3 10 8 0 0.398 1.000 1.000 237 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(1), EGFR(10), ELK1(2), GNAS(5), GNB1(3), GRB2(3), HRAS(1), IGF1R(4), ITGB1(6), MAP2K2(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MYC(1), NGFR(2), PDGFRA(6), PPP2CA(1), PTPRR(6), RAF1(5), RPS6KA5(3), SHC1(4), SOS1(7), SRC(2), STAT3(4) 37048734 85 73 83 16 9 19 8 30 19 0 0.0586 1.000 1.000 238 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), RPE(2), RPIA(3), TKT(3), TPI1(1) 21056188 40 37 39 9 2 7 6 7 18 0 0.444 1.000 1.000 239 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1) 10602345 15 15 15 7 1 0 2 7 5 0 0.800 1.000 1.000 240 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1) 10602345 15 15 15 7 1 0 2 7 5 0 0.800 1.000 1.000 241 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 9 EPX(2), LPO(2), PRDX1(1), PRDX5(2), PRDX6(2), TPO(4), TYR(5) 9704487 18 17 18 5 0 3 3 6 6 0 0.680 1.000 1.000 242 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(4), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(4), CHST4(1), CHST6(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 13759447 29 26 28 9 2 4 2 6 15 0 0.861 1.000 1.000 243 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(3), IFNB1(2), NFKB1(1), RELA(7), TNFRSF11A(2), TRAF6(2) 12774581 18 18 15 6 1 5 1 2 8 1 0.836 1.000 1.000 244 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), NAGLU(3), SPAM1(8) 24277195 59 50 59 13 9 9 8 20 13 0 0.105 1.000 1.000 245 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1R(1), TNF(1) 7202206 4 4 4 2 0 1 0 1 2 0 0.944 1.000 1.000 246 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(1), CASP9(2), CHUK(2), GHR(1), NFKB1(1), NFKBIA(1), PIK3R1(5), PPP2CA(1), RELA(7) 14357763 21 21 18 6 1 5 0 5 9 1 0.738 1.000 1.000 247 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(4) 27416556 45 43 44 9 5 8 8 16 8 0 0.0923 1.000 1.000 248 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(4) 8905159 13 13 13 9 1 0 3 6 3 0 0.984 1.000 1.000 249 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 DPM2(1), HRAS(1), MAP2K2(1), MAPK1(1), MAPK3(3), NGFR(2), RAF1(5) 8327998 14 14 14 5 3 1 2 7 1 0 0.721 1.000 1.000 250 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(2), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3) 16369350 26 23 26 5 2 2 5 9 8 0 0.418 1.000 1.000 251 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 C9orf47(1), CNR1(1), CNR2(3), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), TBXA2R(4) 8828840 20 19 20 9 2 3 2 9 4 0 0.810 1.000 1.000 252 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), NAT1(1), NAT2(1), XDH(7) 9346798 24 24 24 9 4 2 3 10 5 0 0.849 1.000 1.000 253 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3) 18614542 12 12 12 1 0 3 2 4 3 0 0.215 1.000 1.000 254 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 31 AARS(4), AARS2(5), ABAT(2), ACY3(1), ADSL(2), ADSSL1(3), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), ASS1(2), CRAT(2), DARS(4), DARS2(1), DDO(1), DLAT(3), DLD(4), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1) 38463768 80 69 80 13 5 10 13 23 28 1 0.0539 1.000 1.000 255 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), FOS(1), JUN(2), KEAP1(4), MAPK1(1), MAPK14(2), PRKCA(3) 8936645 14 14 14 7 2 1 2 5 4 0 0.895 1.000 1.000 256 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(1), FURIN(3), NOTCH1(9), PSEN1(1) 10180266 17 17 15 5 2 2 0 7 5 1 0.763 1.000 1.000 257 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(8), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF5(4), GSK3B(3) 13614975 25 23 23 7 2 2 6 5 10 0 0.618 1.000 1.000 258 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1) 14570310 23 23 22 7 3 1 2 12 5 0 0.680 1.000 1.000 259 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(11), AXIN1(5), BTRC(4), CREBBP(13), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(4), DVL1(1), FZD1(2), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2) 34392307 71 63 65 13 6 6 10 26 23 0 0.108 1.000 1.000 260 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 28 AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(3), GNE(2), GNPDA1(1), GNPNAT1(2), HEXA(5), HEXB(1), HK1(7), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), PHPT1(1), RENBP(5), UAP1(1) 33058461 62 58 62 10 7 7 12 23 12 1 0.0199 1.000 1.000 261 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 10 AHCY(4), BHMT(5), CBS(1), CTH(2), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTR(1) 14506761 25 25 25 7 1 3 3 10 8 0 0.633 1.000 1.000 262 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(1), CD3G(2), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1) 25372658 58 53 58 12 5 7 8 26 12 0 0.214 1.000 1.000 263 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(1), CD3G(2), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1) 25372658 58 53 58 12 5 7 8 26 12 0 0.214 1.000 1.000 264 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 22 ABAT(2), ALDH4A1(2), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GLS2(4), GLUD1(1), GLUL(2), GMPS(1), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(4) 32529934 54 48 54 9 4 3 10 21 16 0 0.158 1.000 1.000 265 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR2(2), ACTR3(1), ARPC1B(1), CDC42(1), PAK1(4), PDGFRA(6), PIK3R1(5) 11444307 20 20 20 6 2 3 2 8 5 0 0.804 1.000 1.000 266 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(1), GFPT1(3), GNE(2), GNPDA1(1), HEXA(5), HEXB(1), HK1(7), RENBP(5), UAP1(1) 20015585 29 27 29 6 3 2 5 11 8 0 0.292 1.000 1.000 267 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2) 6565915 13 12 13 6 3 2 2 5 1 0 0.657 1.000 1.000 268 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(2), EPOR(1), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4) 25323206 53 49 51 10 4 7 10 18 14 0 0.196 1.000 1.000 269 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC2(5), ABCG2(1), BCHE(2), CES1(8), CES2(2), CYP3A5(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6) 23504087 49 44 47 11 2 5 12 16 14 0 0.384 1.000 1.000 270 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(2), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 34395338 42 41 41 6 3 7 8 12 12 0 0.0562 1.000 1.000 271 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(4), CASP9(2), DAXX(6), FAS(2), FASLG(2), HSPB2(3), MAPKAPK2(2), TNF(1) 12987058 23 21 23 6 2 5 3 7 6 0 0.479 1.000 1.000 272 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR7(1), CD28(1), CXCR4(1), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18R1(1), IL2(1), IL4(1), IL4R(5), TGFB2(2) 22526641 31 30 31 7 5 1 5 12 8 0 0.327 1.000 1.000 273 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(4), HDAC9(3), MEF2A(2), MEF2C(1), MEF2D(1) 9621659 14 14 13 7 2 1 2 5 4 0 0.880 1.000 1.000 274 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL16(5), IL18(1), IL2(1), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1) 11552356 18 17 18 7 0 4 2 8 4 0 0.834 1.000 1.000 275 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TGFB2(2), TNF(1), TRAF6(2) 34819817 56 50 52 9 6 11 1 18 19 1 0.173 1.000 1.000 276 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST6GALNAC4(1), ST8SIA1(2) 6435518 13 13 13 5 1 3 1 7 1 0 0.581 1.000 1.000 277 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(3), DLAT(3), DLD(4), FH(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PDK1(1), PDK2(4), PDK3(2), PDK4(2), PDP2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 33507876 78 67 75 17 3 13 10 25 26 1 0.183 1.000 1.000 278 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2) 7336486 12 12 12 9 4 3 0 4 1 0 0.908 1.000 1.000 279 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2) 7336486 12 12 12 9 4 3 0 4 1 0 0.908 1.000 1.000 280 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RAF1(5), RELA(7), TNF(1) 17910353 32 31 29 9 6 3 2 8 12 1 0.720 1.000 1.000 281 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAX(1), BCL10(2), BCL2L11(1), BID(2), CASP9(2), CES1(8) 13495874 20 20 18 5 0 3 1 8 8 0 0.684 1.000 1.000 282 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CBS(1), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(2) 28969793 54 50 54 10 4 5 14 16 15 0 0.170 1.000 1.000 283 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(5), RPE(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), XYLB(4) 31485702 70 64 70 15 5 9 17 21 18 0 0.203 1.000 1.000 284 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), AKT2(4), AKT3(2), GRB2(3), GSK3A(1), GSK3B(3), IL4R(5), IRS1(6), JAK1(6), JAK3(4), MAP4K1(3), MAPK1(1), MAPK3(3), PDK1(1), PIK3CD(2), PIK3R1(5), PPP1R13B(6), RAF1(5), SHC1(4), SOCS1(1), SOS1(7), SOS2(7), STAT6(4) 38820226 84 74 82 16 12 12 14 29 17 0 0.0440 1.000 1.000 285 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2C1(6), MANBA(2), NEU1(1) 19064206 28 27 28 7 2 4 2 13 7 0 0.404 1.000 1.000 286 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(7) 11072456 20 20 20 6 4 1 4 7 4 0 0.728 1.000 1.000 287 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(2), CREBBP(13), EP300(16), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2) 26534389 53 48 47 11 2 7 10 10 23 1 0.340 1.000 1.000 288 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), IL2(1), IL2RA(2), IL4(1), IL4R(5) 14751873 35 33 35 10 5 3 3 11 13 0 0.621 1.000 1.000 289 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(3), OTC(1), PYCR1(1), SMS(2) 21038884 33 33 33 8 0 2 6 13 12 0 0.659 1.000 1.000 290 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 26 ABAT(2), ACADL(3), ACADM(3), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2) 32785648 64 62 63 14 4 9 18 18 14 1 0.0874 1.000 1.000 291 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(7), IMPA1(1), PGM1(1) 12029426 10 9 10 7 2 1 0 3 4 0 0.954 1.000 1.000 292 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 HLA-DRA(1), HLA-DRB1(6), IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL2(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TNF(1) 14322133 20 19 20 6 0 5 3 7 5 0 0.646 1.000 1.000 293 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2) 11650638 18 18 18 6 1 2 1 10 4 0 0.639 1.000 1.000 294 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(6), GNAS(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SLC9A3R1(1) 15154538 28 28 28 8 3 3 1 14 7 0 0.736 1.000 1.000 295 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(4), AKT1(1), CALM2(1), CALR(2), CAMK1(3), CAMK1G(4), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(2), F2(4), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), LIF(1), MAPK1(1), MAPK14(2), MAPK3(3), MEF2C(1), MYH2(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKX2-5(1), NPPA(1), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAF1(5), RPS6KB1(2), SYT1(1) 56369927 118 102 113 22 16 11 14 37 40 0 0.0388 1.000 1.000 296 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4E(2), GSK3B(3), IGF1R(4), INPPL1(4), PDK2(4), PIK3R1(5), PPP2CA(1), RPS6KB1(2) 19926086 33 31 31 9 5 3 2 9 14 0 0.630 1.000 1.000 297 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(1), CD2(2), CD3E(1), CD3G(2), IFNG(2), IL12RB1(3), IL12RB2(3), JAK2(7), STAT4(2), TYK2(7) 16309281 30 30 29 9 3 0 6 12 9 0 0.817 1.000 1.000 298 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL2(1), IL2RA(2), IL2RB(2), JAK1(6), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4), SYK(2) 27463900 57 54 56 12 7 8 10 18 14 0 0.185 1.000 1.000 299 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5) 12333616 19 19 19 6 3 6 2 6 2 0 0.368 1.000 1.000 300 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(2), AKT1(1), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(1), NOS3(3), NPPA(1), NR3C1(4), PIK3R1(5), RELA(7), SYT1(1) 18354986 35 33 32 9 4 7 1 11 11 1 0.729 1.000 1.000 301 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(1) 23494409 32 30 32 7 3 4 3 15 7 0 0.251 1.000 1.000 302 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), CAT(3), GHR(1), HRAS(1), IGF1R(4), PIK3R1(5), SHC1(4) 12761356 19 17 19 8 3 2 1 8 5 0 0.913 1.000 1.000 303 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1) 8940101 8 7 8 5 1 2 1 3 1 0 0.907 1.000 1.000 304 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), IKBKAP(3), IKBKB(3), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), TNFAIP3(2), TRAF3(1), TRAF6(2) 22031198 30 27 27 6 1 6 0 8 14 1 0.559 1.000 1.000 305 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(3), DPM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), MAPK3(3), NGFR(2), PIK3R1(5), PLCG1(3), RAF1(5), SHC1(4), SOS1(7) 19572366 42 40 41 10 6 8 5 16 7 0 0.383 1.000 1.000 306 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(9), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 8647515 14 13 14 9 3 0 5 5 1 0 0.954 1.000 1.000 307 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(1), PLCG1(3), PRKCA(3), RELA(7) 23987538 44 40 38 10 5 4 5 13 16 1 0.542 1.000 1.000 308 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(1), ADCY1(2), CDC25C(4), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), MYT1(9), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SRC(2) 22056515 46 42 46 10 5 11 4 20 6 0 0.156 1.000 1.000 309 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GCNT2(5), ST8SIA1(2) 17993869 33 30 32 9 5 6 4 9 9 0 0.532 1.000 1.000 310 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(11), ATF2(3), AXIN1(5), BMP10(1), BMP2(1), BMP4(2), BMP5(1), BMP7(5), BMPR1A(2), BMPR2(6), CHRD(5), CTNNB1(4), DVL1(1), FZD1(2), GATA4(2), GSK3B(3), MAP3K7(3), MEF2C(1), MYL2(1), NKX2-5(1), NOG(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), WNT1(2) 42239001 77 66 75 13 9 7 7 33 21 0 0.0471 1.000 1.000 311 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(7), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(5) 29178988 54 51 54 12 4 8 8 24 10 0 0.234 1.000 1.000 312 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), ATP7A(6), ATP7B(9), COX10(5), COX5A(1), COX7A1(2), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(8), SDHB(1), SHMT1(4), UQCRC1(2), UQCRFS1(2) 45252283 107 94 106 22 7 15 21 40 23 1 0.0819 1.000 1.000 313 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), RPE(2), RPIA(3), TKT(3), TKTL1(2), TKTL2(4), TPI1(1) 23560559 44 42 43 10 2 7 6 10 19 0 0.464 1.000 1.000 314 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(7), IMPA1(1), IMPA2(3), PGM1(1) 13618439 13 12 13 9 3 1 0 4 5 0 0.980 1.000 1.000 315 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), HDAC5(3), MEF2A(2), MEF2C(1), MEF2D(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), SLC2A4(3), SYT1(1) 24266643 36 36 35 9 6 3 5 13 9 0 0.350 1.000 1.000 316 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), F2(4), FYN(2), GNAI1(3), GNB1(3), GRB2(3), HRAS(1), JAK2(7), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(3), MAPT(5), MYLK(5), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), SYT1(1) 49429298 95 84 93 17 9 13 11 38 24 0 0.0755 1.000 1.000 317 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAX(1), BID(2), BIK(2), BIRC2(3), BIRC3(6), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1) 15962158 25 25 25 7 0 3 4 12 6 0 0.582 1.000 1.000 318 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), GNMT(1), MAOA(2), MAOB(3), PHGDH(3), PIPOX(3), PISD(1), PSAT1(2), RDH11(4), RDH12(3), RDH13(1), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6), TARS2(5) 50341370 99 91 95 19 11 14 14 31 28 1 0.0437 1.000 1.000 319 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(11), AXIN1(5), CREBBP(13), CTNNB1(4), DVL1(1), EP300(16), FZD1(2), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(13), WNT1(2) 38598774 79 70 70 17 5 5 12 31 26 0 0.313 1.000 1.000 320 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(4), ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1B10(2), AKR1C4(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), LIPA(1), RDH11(4), RDH12(3), RDH13(1), SLC27A5(3), SOAT1(5), SOAT2(2), SRD5A1(1) 36262313 64 61 60 13 6 4 6 32 16 0 0.231 1.000 1.000 321 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 26 ABAT(2), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), HMGCL(2), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1) 29282243 47 46 45 10 7 7 10 14 9 0 0.104 1.000 1.000 322 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLB(2), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(6), POLG2(5), POLH(4), POLI(4), POLK(5), POLL(3), POLM(6), POLQ(12), PRIM1(2), PRIM2(2), REV1(5), REV3L(15), RFC5(2) 48565324 93 79 87 16 5 10 6 44 28 0 0.146 1.000 1.000 323 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX6(1), GSR(2), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), OPLAH(4), TXNDC12(2) 26240822 54 45 51 12 2 4 16 19 13 0 0.246 1.000 1.000 324 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 45 AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(2), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADH(1), HADHA(4), HSD17B4(1), NSD1(12), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(3), PLOD2(7), RDH11(4), RDH12(3), RDH13(1), SETD1A(9), SETD7(1), SETDB1(8), SHMT1(4), SHMT2(6), SPCS1(2), SPCS3(1), SUV39H1(1), SUV39H2(5), TMLHE(1) 64524858 151 126 146 29 12 25 22 51 40 1 0.0231 1.000 1.000 325 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(11), EIF4E(2), FBL(2), GPT(4), LDHB(1), LDHC(3), MAPK14(2), NCL(7) 10521056 32 29 31 10 0 1 11 11 9 0 0.681 1.000 1.000 326 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(16), LPL(6), NCOA1(5), NCOA2(13), PPARG(3), RXRA(2) 21621825 58 50 49 16 4 8 7 12 27 0 0.556 1.000 1.000 327 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(11), CDH1(3), CREBBP(13), EP300(16), MAP3K7(3), MAPK3(3), SKIL(3), TGFB2(2), TGFBR1(1), TGFBR2(1) 30285983 56 52 53 12 3 4 13 18 18 0 0.247 1.000 1.000 328 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), NT5C(1), NT5M(3), NUDT2(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), UCK1(1), UCK2(1), UMPS(3), UNG(2), UPB1(2), UPP1(3) 62134969 111 94 107 19 8 12 16 31 43 1 0.0381 1.000 1.000 329 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(6), CDKN2A(4), E2F1(1), MYC(1), PIK3R1(5), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), RB1(4) 19863230 38 35 38 10 2 7 1 12 14 2 0.538 1.000 1.000 330 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(3), EGF(5), EGFR(10), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4) 41548633 92 81 88 19 10 14 10 28 30 0 0.264 1.000 1.000 331 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), IKBKAP(3), IKBKB(3), LTA(1), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(2), TRAF2(1), TRAF3(1) 26848456 35 31 32 9 2 6 1 11 14 1 0.683 1.000 1.000 332 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(3), BCR(2), BLNK(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK1(1), MAPK3(3), MAPK8IP3(1), PAPPA(5), RPS6KA3(2), SHC1(4), SOS1(7), SYK(2), VAV1(6), VAV2(4), VAV3(2) 35544959 63 57 63 13 7 11 7 29 9 0 0.0979 1.000 1.000 333 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(1), EGFR(10), IGF1R(4), MYC(1), POLR2A(11), PPP2CA(1), PRKCA(3), RB1(4), TEP1(10), TERF1(1), TERT(10), TNKS(5), XRCC5(5) 31948688 66 55 64 16 9 10 7 19 19 2 0.262 1.000 1.000 334 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 30 ABAT(2), ACACA(8), ACADL(3), ACADM(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2) 38047603 70 66 68 15 5 8 17 24 15 1 0.137 1.000 1.000 335 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 16 ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), NCK1(1), NCKAP1(2), NTRK1(6), PSMA7(1), WASF1(1), WASF2(2), WASF3(2) 16029393 20 20 19 9 0 4 1 11 4 0 0.919 1.000 1.000 336 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ACY3(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), FTCD(3), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2) 45166488 75 66 74 14 7 13 13 27 15 0 0.0411 1.000 1.000 337 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 20 ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), PRDX1(1), PRDX5(2), PRDX6(2), TAT(3), TPO(4) 22853351 42 39 41 11 5 6 9 9 13 0 0.404 1.000 1.000 338 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(1), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(15), KDR(6), NOS3(3), PDE2A(1), PDE3A(5), PDE3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKG1(5), PRKG2(4), RYR2(16), SLC7A1(3), SYT1(1), TNNI1(2) 48449080 92 83 92 19 16 16 8 32 20 0 0.0507 1.000 1.000 339 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(3), PSMC3(1), PSMD1(3), PSMD11(3), PSMD12(2), PSMD13(3), PSMD2(8), PSMD6(2) 19030475 40 36 39 10 1 3 5 15 16 0 0.679 1.000 1.000 340 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), ESCO1(4), ESCO2(1), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(3), TPO(4) 37087178 50 47 49 10 5 8 9 12 16 0 0.165 1.000 1.000 341 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(2), PLCG1(3), PRKCA(3), PTK2B(4), SYT1(1) 16069405 20 19 19 9 2 4 2 7 5 0 0.933 1.000 1.000 342 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 29 ABAT(2), ALDH4A1(2), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), GMPS(1), GNPNAT1(2), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSR(2), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(4) 39911573 65 57 65 13 6 3 15 24 17 0 0.197 1.000 1.000 343 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(11), CD2(2), CD33(4), CD5(2), CD7(2), IFNA1(1), IFNB1(2), IFNG(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(2), TLR7(5), TLR9(1) 21545439 49 45 48 14 5 6 12 12 14 0 0.371 1.000 1.000 344 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 44 AADAC(1), ABAT(2), ACADS(3), ACAT1(1), ACSM1(2), AKR1B10(2), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADH(1), HADHA(4), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), ILVBL(5), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(4), PRDX6(2), RDH11(4), RDH12(3), RDH13(1) 46998611 83 77 81 17 9 11 13 30 20 0 0.0854 1.000 1.000 345 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(2), AKT1(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(5), GRB2(3), HRAS(1), MAPK1(1), MAPK14(2), MAPK3(3), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RPS6KA5(3), SOS1(7) 29839223 57 55 57 13 7 11 4 24 11 0 0.266 1.000 1.000 346 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(1), CASP9(2), CDC42(1), CHUK(2), ELK1(2), HRAS(1), MAPK3(3), NFKB1(1), PIK3R1(5), RAF1(5), RALA(3), RALBP1(3), RELA(7) 20046486 36 35 32 10 3 8 2 10 12 1 0.703 1.000 1.000 347 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(23), BMPR1B(1), CCND2(1), CDK4(7), CDKN1B(1), DAZL(1), DMC1(1), ESR2(5), FSHR(2), GJA4(1), LHCGR(1), MLH1(5), NCOR1(11), NR5A1(1), NRIP1(6), PGR(4), PRLR(3), PTGER2(1), SMPD1(5), VDR(2), ZP2(5) 39141890 87 76 81 20 10 11 9 32 24 1 0.278 1.000 1.000 348 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFAT5(9), PDE6A(2), PDE6B(6), PDE6C(2), SLC6A13(7), TF(1) 42372108 74 68 74 16 7 8 17 27 15 0 0.163 1.000 1.000 349 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(1), BCAR1(5), CDKN1B(1), GRB2(3), ILK(4), ITGB1(6), MAPK1(1), MAPK3(3), PDK2(4), PIK3R1(5), PTK2(3), SHC1(4), SOS1(7) 19259387 47 40 45 13 5 7 3 13 18 1 0.719 1.000 1.000 350 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(13), EP300(16), IKBKB(3), IL1B(1), MAP2K3(3), MAP3K7(3), MAPK11(1), MAPK14(2), NFKB1(1), NFKBIA(1), NR3C1(4), RELA(7), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1) 34785504 63 56 57 14 3 7 8 17 27 1 0.535 1.000 1.000 351 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SOS1(7) 26040636 54 50 54 14 9 12 5 18 10 0 0.313 1.000 1.000 352 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 36 ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), BTRC(4), CDC16(4), CDC20(3), CDC23(3), CDC27(10), CUL1(5), CUL2(4), FBXW11(1), FBXW7(5), FZR1(4), ITCH(1), RBX1(1), SKP2(2), SMURF1(1), SMURF2(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP1(7), WWP2(4) 45849254 93 88 89 19 7 8 18 33 25 2 0.128 1.000 1.000 353 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4) 38564648 83 74 81 18 9 13 8 27 26 0 0.323 1.000 1.000 354 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 45 ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP4A11(6), ECHS1(3), EHHADH(6), GCDH(5), HADH(1), HADHA(4), HADHB(4), HSD17B4(1) 54949361 95 87 88 19 8 14 21 33 19 0 0.0429 1.000 1.000 355 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NFKB1(1), PIK3R1(5), RB1(4), RELA(7), SP1(2) 20582528 39 36 36 10 3 5 1 13 14 3 0.757 1.000 1.000 356 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 15 AHCY(4), AMD1(2), BHMT(5), CBS(1), CTH(2), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), MTR(1), TAT(3) 18460832 33 33 33 10 4 4 5 12 8 0 0.615 1.000 1.000 357 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), NOS1(10), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), SYT1(1) 30018132 57 52 56 15 9 8 6 25 9 0 0.293 1.000 1.000 358 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(13), EP300(16), NCOA3(8), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RARA(4), RXRA(2) 24157141 56 54 53 16 3 6 11 17 19 0 0.474 1.000 1.000 359 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 AKR1C3(2), ALOX12(5), ALOX5(4), CBR1(3), CYP4F2(5), CYP4F3(3), EPX(2), GGT1(4), LPO(2), LTA4H(4), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX5(2), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4) 31106776 62 57 60 15 6 8 12 20 15 1 0.345 1.000 1.000 360 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), MAOA(2), MAOB(3), TAT(3), TH(4), TPO(4), TYR(5) 35868369 72 66 70 19 10 7 9 26 20 0 0.423 1.000 1.000 361 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(3), NMNAT3(2), NNMT(1), NNT(9), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT12(2), QPRT(1) 25362589 43 42 43 12 5 5 4 21 8 0 0.560 1.000 1.000 362 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(6), ATM(23), ATR(11), CCNA1(7), CCNE1(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(2), TGFB2(2) 34451653 82 69 73 20 4 9 10 19 37 3 0.454 1.000 1.000 363 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(3), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), THPO(1) 32698271 73 66 71 17 7 10 10 25 21 0 0.498 1.000 1.000 364 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(5), COMT(1), DBH(2), DDC(3), GAD1(2), GAD2(3), HDC(1), MAOA(2), PAH(5), SLC18A3(2), TH(4), TPH1(3) 16415602 34 32 32 11 3 5 8 9 9 0 0.694 1.000 1.000 365 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(2), COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), REN(1) 30108508 44 42 44 13 5 15 4 13 7 0 0.388 1.000 1.000 366 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(10), MAP3K1(8), MAPK14(2), NCOR2(7), RARA(4), RXRA(2), THRA(2) 20230386 40 34 37 11 2 6 7 13 12 0 0.646 1.000 1.000 367 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), DHRS2(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3) 28604464 27 26 26 7 1 4 2 13 7 0 0.646 1.000 1.000 368 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), ASS1(2), CPS1(5), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(1), SAT1(1), SAT2(1), SMS(2) 33327516 56 56 56 14 4 6 10 20 16 0 0.384 1.000 1.000 369 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), ILVBL(5), PANK1(4), PANK2(5), PANK3(2), PANK4(1), PPCDC(1), UPB1(2), VNN1(1) 20256946 36 35 36 11 3 4 6 11 12 0 0.670 1.000 1.000 370 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(1), MAP3K1(8), MAPK1(1), MAPK3(3), NFKB1(1), NSMAF(6), RAF1(5), RELA(7), RIPK1(2), SMPD1(5), TNFRSF1A(1), TRADD(2), TRAF2(1) 23980385 44 38 39 12 6 5 6 12 14 1 0.584 1.000 1.000 371 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(2), ARG2(1), ASL(4), ASS1(2), CKB(1), CKMT1B(1), CPS1(5), DAO(1), EPRS(3), GATM(2), GLUD1(1), GLUD2(1), GOT1(3), GOT2(3), LAP3(4), NOS1(10), NOS3(3), OAT(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(4), PRODH(2), PYCR1(1), PYCR2(3), PYCRL(2), RARS(4), RARS2(2) 42627273 78 69 78 17 7 7 16 25 23 0 0.239 1.000 1.000 372 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(10), CLTA(2), CLTB(2), COPA(7), GBF1(14), GPLD1(2) 18691624 41 39 41 12 2 2 4 19 13 1 0.753 1.000 1.000 373 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(1), APC(11), AXIN1(5), CTNNB1(4), DVL1(1), FZD1(2), GNAI1(3), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(1), PIK3R1(5), PPP2CA(1), RELA(7), TLR4(2), WNT1(2) 33136533 56 54 51 14 4 8 4 21 18 1 0.485 1.000 1.000 374 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL6R(2), IL6ST(5), JAK1(6), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(1), RAF1(5), SHC1(4), SOS1(7), STAT3(4) 27759968 60 56 60 16 5 8 11 24 12 0 0.486 1.000 1.000 375 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(1), EIF4A1(1), EIF4A2(6), EIF4B(4), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(4), PIK3R1(5), PPP2CA(1), RPS6KB1(2), TSC1(5), TSC2(14) 29367719 67 62 65 17 6 9 8 22 19 3 0.478 1.000 1.000 376 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), PGD(1) 21893256 43 37 40 12 2 3 15 12 11 0 0.516 1.000 1.000 377 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(3), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(8), GUCA1B(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(5), PRKG2(4), PRKX(2) 36410808 57 55 54 14 6 11 3 26 11 0 0.332 1.000 1.000 378 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(1), AKT1(1), AKT2(4), AKT3(2), CDKN2A(4), DAPP1(1), GRB2(3), GSK3A(1), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PPP1R13B(6), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SOS1(7), SOS2(7), TEC(5), YWHAB(1) 36899092 63 60 61 15 3 11 9 20 20 0 0.284 1.000 1.000 379 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(1), APC(11), ASAH1(2), BRAF(6), DAG1(3), EGFR(10), GNA15(1), GNAI1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(5), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(5), SRC(2) 58523339 103 89 100 22 10 15 18 37 22 1 0.0913 1.000 1.000 380 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), MAPK1(1), MAPK3(3), PIK3R1(5), RAF1(5), SHC1(4), SOS1(7) 19286451 40 36 40 12 8 6 3 16 7 0 0.514 1.000 1.000 381 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(5), ALOX12B(2), ALOX15B(4), ALOX5(4), CBR1(3), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP2U1(1), CYP4A11(6), CYP4F2(5), CYP4F3(3), DHRS4(4), EPHX2(2), GGT1(4), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 46092757 85 75 83 19 8 9 17 26 23 2 0.218 1.000 1.000 382 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CSK(4), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(3), FBXW7(5), GRAP2(1), GRB2(3), ITK(2), ITPKA(1), ITPKB(3), LCK(1), LCP2(2), MAPK1(1), NCK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLCG1(3), PTPRC(7), RAF1(5), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), SOS1(7), SOS2(7), VAV1(6), ZAP70(1) 65679431 122 105 121 25 14 15 20 43 30 0 0.0770 1.000 1.000 383 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(2), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), PON1(1) 34004058 68 58 68 18 13 11 2 28 13 1 0.304 1.000 1.000 384 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(2), ACACA(8), ACACB(5), ACADM(3), ACAT1(1), ACSS1(3), ACSS2(8), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2) 45815194 82 72 79 19 5 8 19 25 23 2 0.259 1.000 1.000 385 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(1), BCR(2), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(1), PIK3R1(5), RAF1(5), SOS1(7), STAT1(6), STAT5A(4), STAT5B(4) 30035725 60 57 59 16 5 6 7 27 15 0 0.639 1.000 1.000 386 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), F10(1), F11(2), F12(9), F2(4), F2R(2), F5(11), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), PROC(3), PROS1(5), SERPING1(2) 52653516 96 85 94 25 13 19 8 29 26 1 0.243 1.000 1.000 387 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(1), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(6), MAPK1(1), MAPK14(2), MAPK3(3), MKNK1(2), PABPC1(17), PDK2(4), PIK3R1(5), PRKCA(3), RPS6KB1(2) 29642267 76 67 74 20 11 14 9 24 16 2 0.381 1.000 1.000 388 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3) 28671173 43 40 39 12 3 7 4 15 13 1 0.634 1.000 1.000 389 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(6), ILVBL(5), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(6) 20868482 39 34 39 11 3 6 7 13 10 0 0.539 1.000 1.000 390 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(4), AKT3(2), ANKRD6(2), APC(11), AXIN1(5), AXIN2(3), CER1(1), CSNK1A1(2), CTNNB1(4), DACT1(2), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(15), MVP(4), NKD1(4), NKD2(3), PSEN1(1), PTPRA(5), SENP2(2), WIF1(5) 47158166 83 75 79 19 7 12 10 32 22 0 0.176 1.000 1.000 391 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(11), ASAH1(2), CERK(6), CREB1(1), CREB5(3), DAG1(3), EPHB2(3), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 32858438 50 46 47 13 7 4 7 17 15 0 0.531 1.000 1.000 392 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(1), FUCA2(1), GALNS(6), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NAGLU(3), NEU1(1), SPAM1(8) 40294545 77 66 77 20 11 11 10 28 17 0 0.184 1.000 1.000 393 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), GTF2I(3), GTF2IRD1(2), STON1(2), TAF1(7), TAF12(1), TAF1L(7), TAF2(7), TAF4(5), TAF4B(7), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(8), TAF9(1), TAF9B(2), TBPL2(1) 43296524 80 73 76 19 7 13 11 25 24 0 0.190 1.000 1.000 394 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(23), ATR(11), BRCA1(8), CDC25A(2), CDC25B(1), CDC25C(4), CDKN1A(3), CHEK1(1), CHEK2(3), EP300(16), MYT1(9), PRKDC(10), WEE1(2) 47810356 93 80 89 21 4 16 11 33 28 1 0.236 1.000 1.000 395 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 40 ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG5(1), ALG6(3), ALG8(1), ALG9(3), B4GALT1(2), B4GALT2(1), B4GALT3(2), DHDDS(1), DOLPP1(3), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), RPN1(4), RPN2(2), ST6GAL1(1), STT3B(4) 48761352 83 70 82 18 3 14 6 30 30 0 0.355 1.000 1.000 396 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(3), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS16(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS8(1), RPS9(1), RPSA(1) 25781109 60 58 60 14 5 5 8 26 15 1 0.452 1.000 1.000 397 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(5), DIAPH1(7), FYN(2), GSN(4), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PFN1(1), PIK3R1(5), PTK2(3), PXN(3), RAF1(5), ROCK1(7), SHC1(4), SRC(2), TLN1(12) 41498608 85 75 84 21 8 10 7 31 29 0 0.470 1.000 1.000 398 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(8), MYL2(1), MYLK(5), NCF2(2), PAK1(4), PDGFRA(6), PIK3R1(5), PLD1(3), PPP1R12B(3), RALBP1(3), RPS6KB1(2), TRIO(8), VAV1(6), WASF1(1) 38710927 67 64 65 16 6 6 6 27 22 0 0.568 1.000 1.000 399 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(6), ARHGEF5(4), ARPC1B(1), BAIAP2(3), CFL1(1), DIAPH1(7), GSN(4), LIMK1(6), MYL2(1), MYLK(5), OPHN1(2), PFN1(1), PIP5K1A(2), PPP1R12B(3), ROCK1(7), SRC(2), TLN1(12), VCL(3) 53667073 84 77 81 17 4 9 8 28 35 0 0.341 1.000 1.000 400 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(1), AKT1(1), AKT2(4), AKT3(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(6), PITX2(2), PLD1(3), PLD2(5), PLD3(4), VN1R1(1) 53066720 83 72 81 18 9 13 17 25 19 0 0.0587 1.000 1.000 401 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 40 AKT1(1), AKT2(4), AKT3(2), BRAF(6), CAB39(1), DDIT4(1), EIF4B(4), FIGF(2), HIF1A(5), INS(1), MAPK1(1), MAPK3(3), PGF(2), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRKAA1(2), RICTOR(5), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), STK11(2), TSC1(5), TSC2(14), ULK1(2), ULK2(3), ULK3(4), VEGFA(1), VEGFC(2) 56578973 108 100 104 24 13 12 15 37 26 5 0.143 1.000 1.000 402 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), ECH1(3), ESCO1(4), ESCO2(1), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PNPLA3(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SH3GLB1(3), TAT(3), TH(4), TPO(4), TYR(5), TYRP1(4) 68271765 113 97 111 24 11 13 17 42 30 0 0.119 1.000 1.000 403 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(4), ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), SOAT2(2), SRD5A1(1) 26255762 42 41 40 13 4 2 5 22 9 0 0.743 1.000 1.000 404 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(1), CBL(2), CFLAR(3), E2F1(1), FOS(1), GRB2(3), HRAS(1), IL2RA(2), IL2RB(2), IRS1(6), JAK1(6), JAK3(4), MAPK1(1), MAPK3(3), MYC(1), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(5), RPS6KB1(2), SHC1(4), SOCS1(1), SOCS3(2), SOS1(7), STAT5A(4), STAT5B(4), SYK(2) 39312493 77 71 76 20 10 11 13 21 22 0 0.358 1.000 1.000 405 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(2), ACAT1(1), ACMSD(2), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP1A1(1), CYP1A2(6), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADH(1), HADHA(4), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), LCMT2(4), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(4), OGDH(8), OGDHL(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), TDO2(1), TPH1(3), TPH2(2), WARS(1), WARS2(1) 69901063 123 108 120 26 12 20 23 44 24 0 0.0464 1.000 1.000 406 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(2), GNA12(1), GNA13(6), GNB1(3), MYL2(1), MYLK(5), PLCB1(3), PPP1R12B(3), PRKCA(3), ROCK1(7) 24187672 39 39 39 11 3 3 1 19 13 0 0.774 1.000 1.000 407 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNA(2), LMNB1(4), LMNB2(2), PRF1(1) 22532667 39 37 39 11 0 8 8 13 10 0 0.496 1.000 1.000 408 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), CREB1(1), ELK1(2), FOS(1), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RAF1(5), RPS6KA3(2), SYT1(1) 40166491 77 69 74 20 9 9 8 26 25 0 0.554 1.000 1.000 409 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(1), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), SYT1(1), VIPR2(1) 32205681 57 51 51 16 6 6 3 16 25 1 0.756 1.000 1.000 410 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(3), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTK2(3), PXN(3), TLN1(12) 38697850 76 68 73 21 10 8 7 27 24 0 0.511 1.000 1.000 411 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(7), JAK3(4), SOCS3(2), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), TYK2(7) 21777380 49 47 47 15 4 1 10 17 17 0 0.895 1.000 1.000 412 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(9), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(11), CMA1(2), CTSA(2), ENPEP(5), LNPEP(4), MAS1(2), MME(6), REN(1), THOP1(1) 24777470 52 45 48 16 3 5 16 18 10 0 0.621 1.000 1.000 413 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(2), IKBKB(3), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K7(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2) 28790971 45 39 42 12 4 9 3 11 17 1 0.637 1.000 1.000 414 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CD3G(2), ETV5(3), IFNG(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), JAK2(7), JUN(2), MAPK14(2), STAT4(2), TYK2(7) 22004144 37 36 36 11 3 1 6 17 10 0 0.816 1.000 1.000 415 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT2(4), AKT3(2), CISH(2), GRB2(3), IARS(4), IL13RA1(2), IL4(1), IL4R(5), INPP5D(2), JAK1(6), JAK2(7), JAK3(4), PI3(1), PPP1R13B(6), RPS6KB1(2), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT6(4), TYK2(7) 40499550 83 71 82 21 6 12 16 29 20 0 0.325 1.000 1.000 416 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAX(1), BCL2A1(2), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKE(3), LTA(1), MCL1(1), NFKB1(1), NFKBIA(1), NGFR(2), NR3C1(4), NTRK1(6), PTPN13(10), RIPK1(2), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 51089403 77 69 76 17 4 14 12 30 17 0 0.200 1.000 1.000 417 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 20 ALG3(3), ALG5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), DPM1(1), MAN1A1(2), MAN1B1(2), MGAT4A(3), MGAT4B(2), MGAT5(4), RPN1(4), RPN2(2), ST6GAL1(1) 22022504 33 32 33 10 1 6 1 12 13 0 0.815 1.000 1.000 418 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(4), CYP1A2(6), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH12(3), RDH13(1) 28365685 46 43 46 13 5 6 4 19 11 1 0.493 1.000 1.000 419 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), ARHGAP5(5), BCAR1(5), BIRC2(3), BIRC3(6), BRAF(6), CAPN2(3), CAV2(2), CAV3(1), CCND2(1), CCND3(1), CDC42(1), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), CTNNB1(4), DIAPH1(7), DOCK1(2), EGF(5), EGFR(10), ELK1(2), ERBB2(8), FARP2(3), FIGF(2), FLNA(5), FLNB(7), FLNC(7), FLT1(8), FN1(8), FYN(2), GRB2(3), GSK3B(3), HGF(2), HRAS(1), IBSP(1), IGF1R(4), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), JUN(2), KDR(6), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PGF(2), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PRKCA(3), PRKCG(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF1(6), RELN(8), ROCK1(7), ROCK2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SPP1(3), SRC(2), THBS2(3), THBS3(5), THBS4(4), TLN1(12), TLN2(12), TNC(11), TNN(3), TNR(9), TNXB(11), VAV1(6), VAV2(4), VAV3(2), VCL(3), VEGFA(1), VEGFC(2), VTN(1), VWF(15), ZYX(1) 425305732 766 432 747 223 85 112 88 264 211 6 0.369 1.000 1.000 420 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY7(2), ADCY8(12), ADCY9(8), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(3), CD38(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(7), ERBB4(11), F2R(2), GNA14(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(10), GRIN2D(3), GRM1(5), GRM5(8), GRPR(2), HRH2(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), LHCGR(1), LTB4R2(2), MYLK(5), MYLK2(1), NOS1(10), NOS3(3), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), PDE1A(1), PDE1B(6), PDE1C(3), PDGFRA(6), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PPID(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(5), PTK2B(4), RYR1(23), RYR2(16), RYR3(19), SLC25A4(2), SLC25A5(3), SLC25A6(2), SLC8A1(4), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(4), VDAC2(1), VDAC3(3) 319810401 604 386 584 175 94 84 66 209 151 0 0.158 1.000 1.000 421 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(4), ACVR1C(3), AKT1(1), AKT2(4), AKT3(2), ARRB1(2), ARRB2(1), ATF2(3), ATF4(2), BDNF(2), BRAF(6), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D3(1), CACNA2D4(6), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(3), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(2), ELK4(2), FAS(2), FASLG(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FLNA(5), FLNB(7), FLNC(7), FOS(1), GADD45B(2), GNA12(1), GNG12(1), GRB2(3), HRAS(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(7), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(2), MAPT(5), MAX(5), MEF2C(1), MKNK1(2), MKNK2(2), MOS(1), MRAS(1), MYC(1), NF1(15), NFATC2(6), NFATC4(3), NFKB1(1), NFKB2(3), NR4A1(1), NRAS(3), NTRK1(6), NTRK2(3), PAK1(4), PAK2(4), PDGFRA(6), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(1), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(6), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF2(7), RASA1(7), RASA2(1), RASGRF1(11), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), SOS1(7), SOS2(7), STK3(1), STMN1(1), TAOK2(4), TAOK3(3), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(5) 336365767 607 377 595 159 76 82 81 212 154 2 0.0866 1.000 1.000 422 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(3), ACTN1(1), ACTN2(3), ACTN4(4), APC(11), APC2(5), ARHGEF1(2), ARHGEF12(4), ARHGEF4(2), ARHGEF6(3), ARHGEF7(6), ARPC1B(1), ARPC5L(1), BAIAP2(3), BCAR1(5), BDKRB1(1), BDKRB2(1), BRAF(6), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CSK(4), CYFIP1(7), CYFIP2(6), DIAPH1(7), DIAPH2(3), DIAPH3(7), DOCK1(2), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(2), FGD3(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FN1(8), GIT1(2), GNA12(1), GNA13(6), GNG12(1), GSN(4), HRAS(1), INS(1), IQGAP1(5), IQGAP2(6), IQGAP3(7), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), LIMK1(6), LIMK2(3), MAP2K2(1), MAPK1(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(6), MYH14(10), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), NCKAP1(2), NCKAP1L(6), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDGFRA(6), PDGFRB(3), PFN1(1), PFN3(1), PFN4(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PPP1R12B(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RDX(2), ROCK1(7), ROCK2(3), SCIN(4), SLC9A1(3), SOS1(7), SOS2(7), SSH1(4), SSH2(13), SSH3(2), TIAM1(9), TIAM2(2), VAV1(6), VAV2(4), VAV3(2), VCL(3), WAS(1), WASF1(1), WASF2(2) 322425718 602 376 584 154 59 67 85 228 159 4 0.158 1.000 1.000 423 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(4), ACTG1(3), CHAD(5), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DES(1), DSC2(4), DSC3(2), DSG1(5), DSG2(3), DSG3(3), DSG4(4), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(1), GJA9(1), GJB1(2), GJB3(4), GJB6(2), GJB7(1), GJC1(3), GJC2(1), GJC3(1), GJD2(1), IBSP(1), ITGA6(7), ITGB4(7), KRT1(2), KRT10(4), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(4), KRT19(3), KRT2(9), KRT20(1), KRT23(4), KRT24(2), KRT25(2), KRT27(5), KRT28(2), KRT3(7), KRT31(1), KRT32(1), KRT33A(1), KRT33B(3), KRT34(1), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(1), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(4), KRT73(3), KRT74(2), KRT75(3), KRT76(4), KRT77(2), KRT78(3), KRT79(4), KRT81(1), KRT82(3), KRT83(2), KRT84(4), KRT85(6), KRT86(3), KRT9(2), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), LMNA(2), LMNB1(4), LMNB2(2), NES(6), PRPH(2), RELN(8), SPP1(3), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15) 286267176 549 356 535 192 69 86 56 176 159 3 0.941 1.000 1.000 424 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(11), CD44(3), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DAG1(3), FN1(8), FNDC1(2), FNDC3A(3), FNDC5(1), HMMR(1), HSPG2(16), IBSP(1), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), RELN(8), SDC1(1), SDC3(1), SDC4(2), SPP1(3), SV2A(2), SV2B(3), SV2C(3), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15) 258640361 465 321 455 142 50 72 49 153 137 4 0.594 1.000 1.000 425 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), C5AR1(2), CALCR(5), CALCRL(3), CCKAR(4), CCKBR(3), CGA(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(4), CYSLTR1(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(6), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(4), GABRB3(3), GABRD(2), GABRE(4), GABRG1(3), GABRG2(7), GABRG3(3), GABRP(1), GABRQ(9), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(5), GLRA1(5), GLRA2(1), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(9), GRIA2(5), GRIA3(2), GRIA4(4), GRID1(4), GRID2(8), GRIK1(2), GRIK2(4), GRIK3(5), GRIK4(1), GRIK5(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRIN3A(3), GRIN3B(3), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM6(3), GRM7(5), GRM8(3), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HRH4(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LEP(1), LEPR(5), LHCGR(1), LTB4R2(2), MAS1(2), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY1R(2), NPY2R(3), NR3C1(4), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), P2RY1(3), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(2), P2RY8(3), PARD3(7), PRLR(3), PRSS1(6), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGER4(1), PTGFR(5), PTGIR(1), RXFP1(3), RXFP2(1), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAAR2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(3), TSHR(3), TSPO(1), VIPR1(1), VIPR2(1) 254574143 483 316 469 142 66 68 65 179 104 1 0.184 1.000 1.000 426 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB1(2), ARRB2(1), ATP1A4(5), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(4), GJB6(2), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), ITPR1(11), ITPR2(14), ITPR3(7), KCNB1(4), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PLCB3(4), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SLC8A3(4), USP5(4), YWHAB(1) 222914870 423 295 412 136 73 49 42 145 114 0 0.599 1.000 1.000 427 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), AMOTL1(3), ASH1L(8), CASK(1), CDC42(1), CDK4(7), CGN(3), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CRB3(1), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(8), EXOC4(4), F11R(1), GNAI1(3), GNAI2(3), HCLS1(1), HRAS(1), IGSF5(5), INADL(8), JAM3(3), LLGL1(6), LLGL2(2), MAGI1(5), MAGI2(4), MAGI3(5), MLLT4(12), MPDZ(4), MPP5(1), MRAS(1), MYH1(7), MYH10(6), MYH11(9), MYH13(7), MYH14(10), MYH15(6), MYH2(9), MYH3(7), MYH4(16), MYH6(8), MYH7(15), MYH7B(7), MYH8(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), NRAS(3), OCLN(3), PARD3(7), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP2R3A(2), PPP2R3B(1), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), SPTAN1(11), SRC(2), SYMPK(3), TJAP1(3), TJP1(5), TJP2(5), TJP3(2), YES1(2), ZAK(5) 225535060 407 285 392 131 38 46 54 134 133 2 0.940 1.000 1.000 428 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(6), ABLIM1(5), ABLIM2(1), ABLIM3(3), ARHGEF12(4), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(8), DPYSL2(3), EFNA1(3), EFNA2(1), EFNA3(1), EFNA5(1), EFNB1(1), EPHA1(4), EPHA2(1), EPHA3(8), EPHA4(3), EPHA5(8), EPHA6(4), EPHA7(2), EPHA8(3), EPHB1(3), EPHB2(3), EPHB3(1), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(3), GNAI2(3), GSK3B(3), HRAS(1), ITGB1(6), L1CAM(5), LIMK1(6), LIMK2(3), LRRC4C(2), MAPK1(1), MAPK3(3), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NGEF(2), NRAS(3), NRP1(2), NTN1(1), NTN4(2), NTNG1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLXNA1(3), PLXNA2(9), PLXNA3(5), PLXNB1(8), PLXNB2(7), PLXNB3(3), PLXNC1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTK2(3), RAC2(1), RAC3(1), RASA1(7), RGS3(6), RND1(2), ROBO1(5), ROBO2(9), ROBO3(3), ROCK1(7), ROCK2(3), SEMA3A(3), SEMA3C(2), SEMA3D(3), SEMA3E(4), SEMA3F(4), SEMA3G(1), SEMA4A(2), SEMA4B(1), SEMA4C(2), SEMA4D(2), SEMA4F(8), SEMA4G(4), SEMA5A(6), SEMA5B(1), SEMA6A(5), SEMA6B(1), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(10), SLIT3(7), SRGAP1(9), SRGAP2(1), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(4), UNC5D(2) 224198012 401 276 383 126 37 43 47 145 127 2 0.924 1.000 1.000 429 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(1), ACVR1B(4), ACVR2A(5), ACVR2B(1), BMP2(1), BMP7(5), BMPR1A(2), BMPR1B(1), BMPR2(6), CCL2(1), CCL27(3), CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CD27(2), CD40(1), CLCF1(1), CNTF(2), CSF1R(8), CSF2RA(3), CSF2RB(7), CSF3R(3), CX3CL1(2), CX3CR1(1), CXCL11(1), CXCL13(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(3), EDA(1), EDA2R(1), EGF(5), EGFR(10), EPOR(1), FAS(2), FASLG(2), FLT1(8), FLT3(7), FLT4(15), GDF5(3), GH2(1), GHR(1), HGF(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL17RA(2), IL17RB(3), IL18(1), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(7), IL1RAP(4), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), INHBA(2), INHBB(2), INHBC(1), INHBE(2), KDR(6), KITLG(2), LEP(1), LEPR(5), LIF(1), LIFR(4), LTA(1), LTB(1), LTBR(3), NGFR(2), OSM(1), OSMR(1), PDGFC(1), PDGFRA(6), PDGFRB(3), PF4(1), PLEKHO2(2), PRLR(3), RELT(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF4(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(9), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFA(1), VEGFC(2), XCL1(2), XCR1(1) 203105630 355 264 346 72 37 48 44 139 87 0 0.00378 1.000 1.000 430 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(11), APC2(5), AXIN1(5), AXIN2(3), BTRC(4), CACYBP(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(1), CHD8(8), CREBBP(13), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(1), CTNNB1(4), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(3), DVL1(1), DVL2(1), DVL3(1), EP300(16), FBXW11(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(10), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKD1(4), NKD2(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRICKLE1(5), PRICKLE2(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(7), ROCK2(3), RUVBL1(1), SENP2(2), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(3), SMAD3(2), SMAD4(4), SOX17(1), TBL1X(4), TBL1XR1(4), TCF7L1(3), TCF7L2(1), VANGL1(3), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3) 185972645 354 261 344 93 37 39 52 121 105 0 0.270 1.000 1.000 431 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ARRB1(2), ARRB2(1), ATF1(2), ATF2(3), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN2(3), CORIN(2), CRH(1), CRHR1(2), DGKZ(3), ETS2(1), FOS(1), GABPA(1), GABPB2(2), GBA2(6), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(2), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), MIB1(1), MYL2(1), MYL4(1), MYLK2(1), NFKB1(1), NOS1(10), NOS3(3), OXT(1), OXTR(1), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(4), PLCD1(3), PLCG1(3), PLCG2(3), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RLN1(1), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SP1(2), TNXB(11), USP5(4), YWHAB(1) 203596345 357 261 350 106 53 51 37 121 95 0 0.524 1.000 1.000 432 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 126 ACACA(8), ACACB(5), AKT1(1), AKT2(4), AKT3(2), BRAF(6), CALM2(1), CBL(2), CBLB(5), CBLC(2), ELK1(2), EXOC7(8), FASN(8), FLOT1(1), FLOT2(1), FOXO1(3), G6PC(3), GCK(1), GRB2(3), GSK3B(3), GYS1(3), GYS2(2), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(4), IRS1(6), IRS4(1), LIPE(5), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(2), NRAS(3), PCK1(9), PCK2(2), PDE3A(5), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PKLR(1), PPARGC1A(3), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(2), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKAR1A(3), PRKAR2B(4), PRKCI(5), PRKCZ(1), PRKX(2), PTPN1(2), PTPRF(6), PYGB(3), PYGL(1), PYGM(4), RAF1(5), RAPGEF1(6), RHOQ(2), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS3(2), SOCS4(1), SORBS1(2), SOS1(7), SOS2(7), SREBF1(4), TRIP10(2), TSC1(5), TSC2(14) 181982351 333 252 323 74 36 46 49 121 77 4 0.0129 1.000 1.000 433 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(3), CADM1(2), CADM3(2), CD2(2), CD22(4), CD226(1), CD276(2), CD28(1), CD34(2), CD40(1), CD58(1), CD6(4), CD80(1), CD86(3), CD8A(1), CD99(1), CDH1(3), CDH2(7), CDH3(4), CDH4(5), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(8), CNTN2(4), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(7), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(7), ITGA8(2), ITGA9(3), ITGAL(6), ITGAM(9), ITGAV(2), ITGB1(6), ITGB2(2), ITGB7(4), ITGB8(3), JAM3(3), L1CAM(5), MADCAM1(3), MAG(4), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(6), NFASC(8), NLGN1(1), NLGN2(1), NRCAM(3), NRXN1(10), NRXN2(4), NRXN3(4), OCLN(3), PTPRC(7), PTPRF(6), PTPRM(10), PVRL2(5), PVRL3(4), SDC1(1), SDC3(1), SDC4(2), SELE(5), SELL(2), SELP(2), SELPLG(3), SIGLEC1(4), SPN(1), VCAM1(5), VCAN(11) 169226503 353 248 347 111 29 47 46 143 88 0 0.702 1.000 1.000 434 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), AKT2(4), AKT3(2), CBL(2), CBLB(5), CBLC(2), CCND2(1), CCND3(1), CISH(2), CLCF1(1), CNTF(2), CREBBP(13), CSF2RA(3), CSF2RB(7), CSF3R(3), EP300(16), EPOR(1), GH2(1), GHR(1), GRB2(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL19(2), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), IRF9(3), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIF(1), LIFR(4), MYC(1), OSM(1), OSMR(1), PIAS1(5), PIAS2(4), PIAS3(3), PIAS4(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRLR(3), PTPN11(1), PTPN6(3), SOCS1(1), SOCS3(2), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(7), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(2), SPRY2(3), STAM(6), STAT1(6), STAT2(7), STAT3(4), STAT4(2), STAT5A(4), STAT5B(4), STAT6(4), TPO(4), TYK2(7) 167556364 324 239 316 81 26 40 59 110 89 0 0.176 1.000 1.000 435 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADK(2), ADSL(2), ADSSL1(3), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), GART(4), GDA(4), GMPR(3), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(2), NPR1(5), NPR2(7), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(6), PDE1A(1), PDE1C(3), PDE2A(1), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PFAS(4), PKLR(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(2), RRM1(4), RRM2(1), XDH(7) 192024846 321 234 315 74 33 48 35 116 89 0 0.0744 1.000 1.000 436 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(2), CAPN11(6), CAPN2(3), CAPN3(8), CAPN6(2), CAPN7(4), CAPN9(2), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(2), FYN(2), GIT2(4), GRB2(3), ILK(4), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), MAP2K2(1), MAP2K3(3), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(2), MAPK7(1), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PIK3R2(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(7), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(4), SHC3(1), SORBS1(2), SOS1(7), SRC(2), TLN1(12), TNS1(12), VAV2(4), VAV3(2), VCL(3), ZYX(1) 159277847 303 226 293 93 20 42 38 110 91 2 0.681 1.000 1.000 437 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), DRD1(1), DRD2(2), EGF(5), EGFR(10), GJD2(1), GNAI1(3), GNAI2(3), GNAS(5), GRB2(3), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(11), ITPR2(14), ITPR3(7), MAP2K2(1), MAP2K5(3), MAP3K2(2), MAPK1(1), MAPK3(3), MAPK7(1), NPR1(5), NPR2(7), NRAS(3), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), PRKX(2), RAF1(5), SOS1(7), SOS2(7), SRC(2), TJP1(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4) 154887133 288 216 284 94 35 45 33 108 67 0 0.812 1.000 1.000 438 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ATF4(2), CACNA1C(15), CACNA1D(12), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(2), GNAS(5), GRB2(3), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLD1(3), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(4), RAF1(5), SOS1(7), SOS2(7), SRC(2) 151435396 290 215 285 95 38 47 33 105 67 0 0.675 1.000 1.000 439 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 108 ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADK(2), ADSL(2), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), GART(4), GDA(4), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(5), NPR2(7), NT5C(1), NT5M(3), NUDT2(1), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE6B(6), PDE6C(2), PDE7B(1), PDE8A(2), PFAS(4), PKLR(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(4), RRM2(1) 148837796 266 210 262 56 29 36 29 96 76 0 0.0361 1.000 1.000 440 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACP1(1), ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), ACVR1B(4), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(3), CREBBP(13), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(4), INSR(4), IQGAP1(5), LEF1(3), LMO7(15), MAP3K7(3), MAPK1(1), MAPK3(3), MLLT4(12), PARD3(7), PTPN1(2), PTPN6(3), PTPRB(7), PTPRF(6), PTPRJ(11), PTPRM(10), PVRL2(5), PVRL3(4), RAC2(1), RAC3(1), SMAD2(3), SMAD3(2), SMAD4(4), SNAI1(1), SNAI2(4), SORBS1(2), SRC(2), SSX2IP(3), TCF7L1(3), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(5), VCL(3), WAS(1), WASF1(1), WASF2(2), WASF3(2), YES1(2) 136786189 274 209 256 73 27 29 50 90 77 1 0.304 1.000 1.000 441 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 BRAF(6), CACNA1A(14), CRH(1), CRHR1(2), GNA12(1), GNA13(6), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(9), GRIA2(5), GRIA3(2), GRID2(8), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), IGF1R(4), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), MAP2K2(1), MAPK1(1), MAPK3(3), NOS1(10), NOS3(3), NPR1(5), NPR2(7), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), RAF1(5), RYR1(23) 129953828 268 208 265 73 43 27 25 103 69 1 0.327 1.000 1.000 442 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(3), ACTN4(4), DES(1), DMD(16), MYBPC1(5), MYBPC2(3), MYBPC3(3), MYH3(7), MYH6(8), MYH7(15), MYH8(8), MYL1(3), MYL2(1), MYL4(1), MYL9(1), MYOM1(6), NEB(18), TCAP(1), TMOD1(6), TNNI1(2), TNNT1(3), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(125), VIM(2) 164621760 249 202 243 78 20 37 34 101 53 4 0.725 1.000 1.000 443 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(6), ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), ATM(23), ATR(11), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDC14A(6), CDC16(4), CDC20(3), CDC23(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC27(10), CDC6(3), CDC7(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(5), DBF4(2), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(11), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), PCNA(3), PKMYT1(1), PLK1(1), PRKDC(10), RB1(4), RBL2(3), RBX1(1), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(4), SMC1A(3), SMC1B(4), TGFB2(2), WEE1(2), YWHAB(1) 160520723 285 199 270 72 20 36 43 90 92 4 0.150 1.000 1.000 444 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 BID(2), BRAF(6), CD48(1), FAS(2), FASLG(2), FYN(2), GRB2(3), HCST(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(6), ITGB2(2), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(2), KLRK1(3), LCK(1), LCP2(2), MAP2K2(1), MAPK1(1), MAPK3(3), MICA(2), MICB(3), NCR1(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NRAS(3), PAK1(4), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRF1(1), PRKCA(3), PRKCG(5), PTK2B(4), PTPN11(1), PTPN6(3), RAC2(1), RAC3(1), RAF1(5), SH2D1B(1), SH3BP2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFSF10(9), ULBP1(1), ULBP2(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1) 128953611 272 199 263 63 25 38 36 102 69 2 0.137 1.000 1.000 445 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(3), ACTN4(4), ARHGAP5(5), BCAR1(5), CD99(1), CDC42(1), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), CXCR4(1), ESAM(1), EZR(2), F11R(1), GNAI1(3), GNAI2(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), ITK(2), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP2(6), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(2), NCF4(1), NOX1(7), NOX3(6), OCLN(3), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAC2(1), RAP1A(1), RAPGEF3(2), RAPGEF4(3), ROCK1(7), ROCK2(3), SIPA1(4), THY1(1), VAV1(6), VAV2(4), VAV3(2), VCAM1(5), VCL(3) 144115270 258 193 250 81 31 29 32 92 73 1 0.821 1.000 1.000 446 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ASIP(2), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3L1(3), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(13), CTNNB1(4), DCT(5), DVL1(1), DVL2(1), DVL3(1), EDNRB(3), EP300(16), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), LEF1(3), MAP2K2(1), MAPK1(1), MAPK3(3), MC1R(2), MITF(4), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), POMC(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), TCF7L1(3), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3) 125155843 247 193 240 72 33 33 27 90 64 0 0.378 1.000 1.000 447 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(8), AKAP2(2), AKAP3(3), AKAP4(3), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(20), ARHGEF1(2), CALM2(1), CHMP1B(3), GNA12(1), GNA13(6), GNA14(1), GNA15(1), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG10(1), GNG12(1), GNG13(1), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(4), NRAS(3), PALM2(1), PDE1A(1), PDE1B(6), PDE1C(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(4), SLC9A1(3), USP5(4) 137257502 254 192 248 75 24 35 17 100 77 1 0.695 1.000 1.000 448 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENPP1(2), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), G6PC(3), GAA(4), GANC(4), GBA(2), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), IFIH1(2), MGAM(8), MOV10L1(8), NUDT5(4), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SI(9), SKIV2L2(2), SMARCA2(6), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UXS1(1) 151904382 257 192 250 81 17 32 45 84 78 1 0.832 1.000 1.000 449 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CHML(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(5), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR83(2), GPR85(3), GPR87(4), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LHCGR(1), MAS1(2), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMUR2(4), NPY1R(2), NPY2R(3), NTSR1(2), OPN1SW(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(1), OR1Q1(1), OR7A5(2), OR7C1(2), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TBXA2R(4), TRHR(2) 136556213 239 190 237 84 37 31 32 97 42 0 0.627 1.000 1.000 450 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(1), BMPR1A(2), BMPR2(6), BUB1(1), CDKL1(1), CDKL2(4), CDS2(1), CLK1(5), CLK2(3), CLK4(8), COL4A3BP(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MAP3K10(4), MOS(1), NEK1(4), NEK3(4), OCRL(3), PAK4(5), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(5), RAF1(5), RPS6KA3(2), RPS6KA4(2), RPS6KB1(2), STK11(2), TGFBR1(1), VRK1(1) 129807199 237 186 235 56 19 32 28 77 81 0 0.150 1.000 1.000 451 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(3), CLK3(2), CLK4(8), COL2A1(7), CPSF1(3), CPSF2(3), CPSF3(5), CPSF4(2), CSTF1(1), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(8), DHX15(3), DHX16(4), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(5), GIPC1(2), METTL3(6), NCBP2(1), NONO(2), NUDT21(2), NXF1(5), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(11), PPM1G(3), PRPF18(3), PRPF3(2), PRPF4B(5), PRPF8(15), PSKH1(1), PTBP1(1), PTBP2(2), RBM17(2), RBM5(3), RNGTT(1), RNMT(3), SF3A1(3), SF3A3(2), SF3B1(14), SF3B2(4), SNRPA(1), SNRPA1(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(1), SRPK2(3), SRRM1(4), SUPT5H(7), TXNL4A(1), U2AF2(4), XRN2(3) 124661384 218 183 214 49 16 41 25 79 56 1 0.0842 1.000 1.000 452 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(6), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGEF6(3), ARHGEF7(6), BCAR1(5), BRAF(6), CDC42(1), CDKN2A(4), CSE1L(5), DOCK1(2), EPHB2(3), FYN(2), GRB2(3), GRB7(6), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGB3BP(1), MAP2K7(3), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(5), MYLK2(1), P4HB(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CB(6), PKLR(1), PLCG1(3), PLCG2(3), PTK2(3), RAF1(5), RALA(3), RHO(1), ROCK1(7), ROCK2(3), SHC1(4), SOS1(7), SOS2(7), SRC(2), TERF2IP(1), TLN1(12), TLN2(12), WAS(1), ZYX(1) 140618481 253 183 245 72 16 36 32 91 75 3 0.552 1.000 1.000 453 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(9), ABCA10(8), ABCA12(13), ABCA13(21), ABCA2(3), ABCA3(4), ABCA4(10), ABCA5(8), ABCA6(4), ABCA7(15), ABCA8(7), ABCA9(3), ABCB1(6), ABCB10(1), ABCB11(4), ABCB4(7), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(2), ABCB9(1), ABCC10(6), ABCC11(6), ABCC12(4), ABCC2(5), ABCC3(10), ABCC4(7), ABCC5(5), ABCC6(10), ABCC8(5), ABCC9(4), ABCD1(3), ABCD2(2), ABCD3(3), ABCD4(4), ABCG1(2), ABCG2(1), ABCG4(8), ABCG5(2), ABCG8(5), CFTR(6), TAP2(1) 135801896 236 182 228 76 14 32 32 95 62 1 0.762 1.000 1.000 454 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM2(1), CDS2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), OCRL(3), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3C3(4), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PRKCA(3), PRKCG(5), PTPMT1(1), SYNJ1(5), SYNJ2(6) 144650028 238 181 233 78 26 35 26 80 70 1 0.807 1.000 1.000 455 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(2), ADCY8(12), ATF4(2), BRAF(6), CACNA1C(15), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(16), GRIA1(9), GRIA2(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRM1(5), GRM5(8), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), MAP2K2(1), MAPK1(1), MAPK3(3), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), RAP1A(1), RAPGEF3(2), RPS6KA3(2), RPS6KA6(1) 116631551 226 181 218 61 28 29 28 81 59 1 0.252 1.000 1.000 456 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(6), ABL2(5), AKT1(1), AKT2(4), AKT3(2), AREG(1), BRAF(6), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(5), CBLC(2), CDKN1A(3), CDKN1B(1), EGF(5), EGFR(10), ELK1(2), ERBB2(8), ERBB3(7), ERBB4(11), GAB1(1), GRB2(3), GSK3B(3), HRAS(1), JUN(2), MAP2K2(1), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(1), NCK1(1), NCK2(1), NRAS(3), NRG1(4), NRG2(3), NRG3(5), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), RAF1(5), RPS6KB1(2), RPS6KB2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SRC(2), STAT5A(4), STAT5B(4) 117852500 237 178 227 53 22 32 35 86 60 2 0.0625 1.000 1.000 457 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(10), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C2(5), C3(9), C3AR1(4), C4A(1), C4BPA(3), C4BPB(3), C5(7), C5AR1(2), C6(3), C7(4), C8A(3), C8B(2), C8G(2), C9(1), CD46(1), CD55(2), CFB(2), CFH(5), CFI(1), CPB2(6), CR1(11), CR2(4), F10(1), F11(2), F12(9), F13A1(3), F13B(3), F2(4), F2R(2), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), KNG1(5), MASP1(5), MASP2(2), MBL2(2), PLAT(4), PLAUR(2), PLG(6), PROC(3), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(2), TFPI(1), VWF(15) 113053817 220 173 212 47 23 28 25 90 51 3 0.0312 1.000 1.000 458 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 105 A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG6(3), ALG8(1), ALG9(3), B3GNT1(2), B3GNT2(4), B3GNT6(3), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT5(3), CHST1(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST2(4), CHST3(2), CHST4(1), CHST6(1), CHST7(1), EXT1(3), EXT2(3), EXTL1(2), EXTL3(3), FUT11(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), NDST1(3), NDST2(4), NDST4(9), OGT(6), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), WBSCR17(4), XYLT1(4), XYLT2(2) 124384084 231 172 225 68 18 35 25 76 77 0 0.735 1.000 1.000 459 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(1), AKT2(4), AKT3(2), BCL10(2), CARD11(9), CBL(2), CBLB(5), CBLC(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), CDC42(1), CDK4(7), CHUK(2), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(3), HRAS(1), ICOS(3), IFNG(2), IKBKB(3), IL2(1), IL4(1), ITK(2), JUN(2), LCK(1), LCP2(2), MALT1(2), MAP3K8(1), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(7), RASGRP1(3), SOS1(7), SOS2(7), TEC(5), TNF(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1) 114936683 222 167 213 39 20 25 31 89 57 0 0.0109 1.000 1.000 460 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(4), CABIN1(11), CALM2(1), CAMK2B(3), CAMK4(3), CD3E(1), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(13), CSNK2A1(3), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(2), EP300(16), FCER1A(1), FKBP1B(1), FOS(1), GATA3(3), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(3), IFNA1(1), IFNB1(2), IFNG(2), IL1B(1), IL2(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(2), KPNA5(2), MAP2K7(3), MAPK14(2), MAPK9(2), MEF2A(2), MEF2D(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(9), OPRD1(3), P2RX7(2), PAK1(4), PPIA(1), PPP3CB(1), PPP3CC(3), PTPRC(7), RELA(7), SFN(1), SLA(1), SP1(2), SP3(3), TNF(1), TRAF2(1), TRPV6(5), VAV1(6), VAV2(4), VAV3(2), XPO5(5) 105905814 214 166 203 53 22 21 34 69 66 2 0.307 1.000 1.000 461 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(5), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(6), CHRD(5), CREBBP(13), CUL1(5), DCN(3), E2F5(2), EP300(16), GDF5(3), GDF6(2), GDF7(1), IFNG(2), INHBA(2), INHBB(2), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(8), MAPK1(1), MAPK3(3), MYC(1), NODAL(2), NOG(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), RBL2(3), RBX1(1), ROCK1(7), ROCK2(3), RPS6KB1(2), RPS6KB2(3), SMAD1(1), SMAD2(3), SMAD3(2), SMAD4(4), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(1), SMURF2(4), SP1(2), TGFB2(2), TGFBR1(1), TGFBR2(1), THBS2(3), THBS3(5), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(7) 110620836 198 164 195 48 20 16 33 68 61 0 0.188 1.000 1.000 462 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(8), ASH2L(2), CTCFL(7), DOT1L(8), EHMT1(4), EHMT2(8), EZH1(4), EZH2(4), FBXO11(5), HCFC1(10), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(13), MEN1(1), NSD1(12), OGT(6), PAXIP1(4), PPP1CC(2), PRDM2(8), PRDM6(2), PRDM7(3), PRDM9(6), PRMT1(1), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), RBBP5(4), SATB1(3), SETD1A(9), SETD1B(1), SETD7(1), SETDB1(8), SETDB2(1), SETMAR(3), SMYD3(2), SUV39H1(1), SUV39H2(5), SUV420H1(2), SUZ12(6), WHSC1(5), WHSC1L1(5) 138050843 196 162 195 54 15 26 27 63 63 2 0.432 1.000 1.000 463 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(11), CD19(1), CD1A(2), CD1B(1), CD1C(3), CD1D(3), CD1E(2), CD2(2), CD22(4), CD33(4), CD34(2), CD38(1), CD3E(1), CD3G(2), CD44(3), CD5(2), CD55(2), CD7(2), CD8A(1), CD9(1), CR1(11), CR2(4), CSF1R(8), CSF2RA(3), CSF3R(3), DNTT(4), EPOR(1), FCER2(1), FCGR1A(1), FLT3(7), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(7), IL2RA(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL7R(1), IL9R(4), ITGA1(8), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGAM(9), ITGB3(4), KITLG(2), MME(6), MS4A1(1), TFRC(4), THPO(1), TNF(1), TPO(4) 95872087 206 157 197 46 16 20 30 70 69 1 0.185 1.000 1.000 464 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 ABL1(6), ATM(23), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDAN1(7), CDC14A(6), CDC20(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC6(3), CDC7(1), CDH1(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F5(2), EP300(16), ESPL1(11), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MPEG1(1), PCNA(3), PLK1(1), PRKDC(10), PTPRA(5), RB1(4), SKP2(2), SMAD4(4), TBC1D8(1), WEE1(2) 129823957 220 155 207 59 17 27 37 65 70 4 0.242 1.000 1.000 465 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(5), AKT1(1), AKT2(4), AKT3(2), APAF1(4), ATM(23), BAX(1), BID(2), BIRC2(3), BIRC3(6), CAPN1(2), CAPN2(3), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), CSF2RB(7), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(6), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(9), TRADD(2), TRAF2(1) 95356023 186 151 176 31 18 24 25 69 49 1 0.00292 1.000 1.000 466 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(3), BRAF(6), CEBPA(2), CHUK(2), CREB1(1), DAXX(6), ELK1(2), FOS(1), GRB2(3), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP3K9(4), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK4(2), MAPK6(2), MAPK7(1), MAPK9(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MKNK2(2), MYC(1), NFKB1(1), NFKBIA(1), PAK1(4), PAK2(4), RAF1(5), RELA(7), RIPK1(2), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KB1(2), RPS6KB2(3), SHC1(4), SP1(2), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 111806764 197 149 191 44 18 19 23 70 65 2 0.226 1.000 1.000 467 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(4), AKT3(2), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(2), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K7(3), MAP3K8(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), RELA(7), RIPK1(2), SPP1(3), STAT1(6), TBK1(4), TICAM1(3), TLR1(4), TLR2(3), TLR3(2), TLR4(2), TLR5(5), TLR6(2), TLR7(5), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2) 102120204 172 144 167 38 19 20 22 73 37 1 0.127 1.000 1.000 468 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(5), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(1), AKT2(4), AKT3(2), CAMKK1(5), CAMKK2(3), CHUK(2), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), G6PC(3), IKBKB(3), IRS1(6), IRS4(1), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NPY(1), PCK1(9), PCK2(2), POMC(2), PPARGC1A(3), PRKAA1(2), PRKAB1(1), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKCQ(4), PTPN11(1), RELA(7), RXRA(2), RXRB(5), RXRG(2), SLC2A1(1), SLC2A4(3), SOCS3(2), STAT3(4), STK11(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TYK2(7) 93038678 170 141 164 42 14 23 33 49 50 1 0.306 1.000 1.000 469 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 58 AKT1(1), AKT2(4), AKT3(2), CDC42(1), CDK2(2), CDKN1B(1), CDKN2A(4), CREB1(1), CREB5(3), ERBB4(11), F2RL2(2), GAB1(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), MYC(1), NOLC1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARD3(7), PDK1(1), PIK3CD(2), PPP1R13B(6), PREX1(9), PTK2(3), PTPN1(2), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(7), SOS2(7), TSC1(5), TSC2(14), YWHAB(1) 79860296 153 132 149 34 15 22 19 48 46 3 0.0931 1.000 1.000 470 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5E(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), COX10(5), COX15(4), COX17(1), COX5A(1), COX6B2(1), COX7A1(2), COX7C(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB9(1), NDUFC1(2), NDUFS1(8), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA1(2), PPA2(2), SDHA(8), SDHB(1), SDHD(2), TCIRG1(1), UQCRC1(2), UQCRC2(4), UQCRFS1(2) 66091202 148 131 147 36 12 16 27 56 36 1 0.221 1.000 1.000 471 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(3), APH1A(2), CREBBP(13), CTBP1(2), CTBP2(1), DLL1(1), DLL3(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(1), DVL3(1), EP300(16), HDAC1(2), JAG1(10), JAG2(3), MAML1(8), MAML2(5), MAML3(7), NCOR2(7), NCSTN(2), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), NUMB(3), NUMBL(2), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(4), SNW1(4) 77886191 158 128 152 64 16 13 19 48 59 3 0.997 1.000 1.000 472 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(1), AKT2(4), AKT3(2), BCL10(2), BLNK(1), CARD11(9), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(2), JUN(2), LILRB3(4), LYN(3), MALT1(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(6), VAV2(4), VAV3(2) 84553849 151 125 143 34 17 17 17 58 42 0 0.182 1.000 1.000 473 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(3), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(2), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(3), UPB1(2), UPP1(3), UPP2(3), UPRT(3) 90994738 151 124 147 32 12 23 21 46 48 1 0.0573 1.000 1.000 474 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(1), AKT2(4), AKT3(2), CASP9(2), CDC42(1), HRAS(1), KDR(6), MAP2K2(1), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPKAPK2(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NOS3(3), NRAS(3), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PRKCG(5), PTGS2(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(2), SRC(2), VEGFA(1) 81141393 151 124 147 47 15 19 19 56 42 0 0.733 1.000 1.000 475 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), MAP4K1(3), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), PDK1(1), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPRC(7), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6) 83657676 151 123 145 34 17 21 22 52 39 0 0.0898 1.000 1.000 476 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(4), ATM(23), ATR(11), BAI1(4), BAX(1), BID(2), CASP8(1), CASP9(2), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CD82(3), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), FAS(2), GADD45B(2), GTSE1(4), IGFBP3(1), PERP(1), PPM1D(2), RCHY1(3), RFWD2(4), RRM2(1), SERPINB5(4), SESN1(3), SFN(1), STEAP3(2), TNFRSF10B(1), TP53I3(4), TP73(4), TSC2(14), ZMAT3(1) 71745677 145 122 139 31 16 23 19 36 49 2 0.0621 1.000 1.000 477 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(1), AKT2(4), AKT3(2), FCER1A(1), FYN(2), GAB2(1), GRB2(3), HRAS(1), IL3(1), IL4(1), INPP5D(2), LCP2(2), LYN(3), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(3), PDK1(1), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PRKCA(3), PRKCD(5), PRKCE(4), RAC2(1), RAC3(1), RAF1(5), SOS1(7), SOS2(7), SYK(2), TNF(1), VAV1(6), VAV2(4), VAV3(2) 81711280 140 121 138 39 17 21 21 54 27 0 0.345 1.000 1.000 478 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(23), CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CREB3L1(3), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(2), GBA2(6), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MNAT1(1), MYC(1), MYT1(9), PCNA(3), POLE(6), POLE2(1), PRIM1(2), RB1(4), RPA1(2), RPA2(2), RPA3(1), TFDP2(5), TNXB(11), WEE1(2) 83849290 154 120 145 34 16 20 17 46 52 3 0.0928 1.000 1.000 479 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), FPGS(4), GGH(3), IFIH1(2), MOV10L1(8), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SKIV2L2(2), SMARCA2(6), SMARCA5(3) 73666171 142 120 138 45 10 26 24 44 37 1 0.539 1.000 1.000 480 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(4), ACADL(3), ACADM(3), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(4), APOA1(1), APOA5(2), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(6), CYP7A1(1), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(2), GK2(3), HMGCS2(3), ILK(4), LPL(6), ME1(1), MMP1(1), NR1H3(2), PCK1(9), PCK2(2), PLTP(2), PPARD(1), PPARG(3), RXRA(2), RXRB(5), RXRG(2), SCP2(3), SLC27A1(2), SLC27A2(1), SLC27A5(3), SLC27A6(6), SORBS1(2), UBC(6), UCP1(1) 73935986 145 119 138 40 11 24 24 47 39 0 0.469 1.000 1.000 481 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1E(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(8), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(29), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(10), PTCH2(3), SHH(3), SMO(5), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3), ZIC2(2) 68456686 140 119 133 40 19 19 14 52 36 0 0.533 1.000 1.000 482 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 46 ADCY4(4), ADCY6(3), ADCY8(12), CACNA1A(14), CACNA1B(9), GNAS(5), GNB1(3), GNB3(2), GNG13(1), GNG3(1), GRM4(5), ITPR3(7), KCNB1(4), PDE1A(1), PLCB2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(5), SCNN1B(5), SCNN1G(2), TAS1R1(2), TAS1R2(6), TAS1R3(6), TAS2R10(1), TAS2R13(2), TAS2R38(3), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R46(2), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 65571392 135 119 133 37 29 18 15 44 29 0 0.209 1.000 1.000 483 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(6), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(3), ETS2(1), ETV6(2), FMN2(8), GRB2(3), MAPK1(1), MAPK3(3), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), PIWIL1(2), PIWIL2(2), PIWIL3(5), PIWIL4(4), RAF1(5), SOS1(7), SOS2(7), SPIRE1(1), SPIRE2(3) 59264803 136 118 131 31 23 12 20 48 30 3 0.158 1.000 1.000 484 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), APOA1(1), CITED2(2), CPT1B(1), CREBBP(13), DUT(1), EHHADH(6), EP300(16), FABP1(3), HSD17B4(1), HSPA1A(1), INS(1), JUN(2), LPL(6), MAPK1(1), MAPK3(3), ME1(1), MRPL11(1), MYC(1), NCOA1(5), NCOR1(11), NCOR2(7), NFKBIA(1), NR1H3(2), NR2F1(2), NRIP1(6), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PTGS2(5), RB1(4), RELA(7), RXRA(2), SP1(2), STAT5A(4), STAT5B(4), TNF(1) 71750898 146 117 136 47 9 20 19 45 50 3 0.883 1.000 1.000 485 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(1), CCR5(1), CELSR1(16), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(3), CIDEB(2), EMR2(3), EMR3(9), F2R(2), FSHR(2), GPR116(6), GPR133(7), GPR143(1), GPR17(2), GPR18(2), GPR56(1), GPR61(1), GPR84(3), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(11), LTB4R2(2), NTSR1(2), OR2M4(1), P2RY11(1), P2RY13(1), PTGFR(5), SMO(5), SSTR2(2), TSHR(3), VN1R1(1) 76067456 146 114 141 41 19 17 23 52 35 0 0.348 1.000 1.000 486 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGAP1(1), ARHGEF11(6), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(11), ITPR2(14), ITPR3(7), LIMK1(6), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(6), RACGAP1(2), RHO(1), ROCK1(7), ROCK2(3), SAG(5), WASF1(1) 77925024 131 113 128 34 12 23 14 43 39 0 0.294 1.000 1.000 487 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(4), AKT3(2), ASAH1(2), BRAF(6), DAG1(3), DRD2(2), EGFR(10), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PI3(1), PIK3CB(6), PITX2(2), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), RAF1(5), RGS20(1), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT3(4), TERF2IP(1) 68747148 134 113 131 33 14 21 24 42 32 1 0.116 1.000 1.000 488 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), CDC42(1), CHUK(2), CSK(4), EGFR(10), F11R(1), GIT1(2), IGSF5(5), IKBKB(3), JAM3(3), JUN(2), LYN(3), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(4), PLCG1(3), PLCG2(3), PTPN11(1), PTPRZ1(15), RELA(7), SRC(2), TCIRG1(1), TJP1(5) 80351719 140 112 131 35 12 14 21 54 37 2 0.418 1.000 1.000 489 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(4), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(4), LMNA(2), LMNB1(4), LMNB2(2), MAP2K7(3), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKBIA(1), NUMA1(5), PAK2(4), PRKCD(5), PRKDC(10), PSEN1(1), PSEN2(2), PTK2(3), RASA1(7), RB1(4), RELA(7), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 81693533 137 110 134 40 4 21 22 44 43 3 0.580 1.000 1.000 490 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(3), CALR(2), CANX(3), CD74(1), CD8A(1), CIITA(5), CREB1(1), CTSB(4), CTSS(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(3), KLRC1(2), KLRC2(3), KLRC3(2), LTA(1), NFYA(3), NFYC(3), PSME2(2), RFX5(4), RFXAP(1), TAP2(1) 50706489 141 110 138 37 6 21 19 62 32 1 0.546 1.000 1.000 491 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5E(2), INPPL1(4), IPMK(1), ITPK1(3), ITPKA(1), ITPKB(3), MINPP1(2), MIOX(2), OCRL(3), PI4KA(11), PI4KB(3), PIK3C3(4), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PTPMT1(1), SYNJ1(5), SYNJ2(6) 83869183 132 109 128 50 11 15 14 46 45 1 0.982 1.000 1.000 492 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(11), AXIN1(5), CCND2(1), CCND3(1), CSNK1E(3), CTNNB1(4), DVL1(1), DVL2(1), DVL3(1), FBXW2(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LDLR(4), MAPK10(2), MAPK9(2), MYC(1), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(1), WNT7B(2) 67682022 123 109 120 31 16 18 10 41 38 0 0.246 1.000 1.000 493 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(20), B3GALT4(2), CDR1(2), DGKI(1), IL6ST(5), PIGK(2), RPL10(1), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(1), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS16(1), RPS19(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(6) 59003100 117 107 117 32 7 11 18 50 30 1 0.602 1.000 1.000 494 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(12), EEF1A2(4), EEF1B2(3), EEF1D(1), EEF1G(3), EEF2(2), EEF2K(2), EIF1AX(1), EIF2AK1(4), EIF2AK2(4), EIF2AK3(3), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G3(7), EIF5(4), EIF5A(2), EIF5B(1), ETF1(2), GSPT2(1), PABPC1(17), PABPC3(17), PAIP1(4), SLC35A4(3) 51821999 126 106 120 37 16 23 18 38 28 3 0.471 1.000 1.000 495 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1C1(2), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(6), CYP1B1(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(4), EPHX1(5), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6) 66816292 126 105 124 32 12 11 22 50 30 1 0.363 1.000 1.000 496 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AGK(7), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CEL(2), DAK(3), DGAT2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), GK(2), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(5), LIPA(1), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PNPLA3(3), PPAP2B(2), PPAP2C(3) 68327507 118 102 117 30 14 16 15 40 33 0 0.195 1.000 1.000 497 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(3), ACSS2(8), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GALM(2), GAPDH(3), GAPDHS(4), GCK(1), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGAM4(1), PGK1(3), PGK2(1), PGM1(1), PKLR(1), TPI1(1) 67032935 116 99 108 29 12 10 16 33 43 2 0.458 1.000 1.000 498 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(2), G6PC(3), GAA(4), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), MGAM(8), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UXS1(1) 73684147 117 96 114 34 10 11 19 38 39 0 0.747 1.000 1.000 499 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(2), CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(3), ETS2(1), FOS(1), HOXA7(2), HRAS(1), IKBKB(3), JUN(2), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(3), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), RAF1(5), RELA(7), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRAF2(1) 57163113 113 94 107 30 13 8 7 43 41 1 0.735 1.000 1.000 500 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(1), BAX(1), BFAR(2), CASP10(3), CASP8(1), CD7(2), CSNK1A1(2), DAXX(6), DEDD(2), DFFA(1), EGFR(10), EPHB2(3), FAF1(1), FAIM2(1), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PFN1(1), PTPN13(10), RALBP1(3), RIPK1(2), ROCK1(7), SMPD1(5), TPX2(2), TRAF2(1) 76404573 112 94 108 30 17 9 13 48 25 0 0.463 1.000 1.000 501 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(4), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(1), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(2), HELLS(2), IKBKB(3), IRF2(2), IRF4(1), IRF5(3), IRF6(6), IRF7(2), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFSF10(9), TP73(4), TRADD(2), TRAF2(1), TRAF3(1) 66119539 112 93 102 31 6 18 15 36 36 1 0.549 1.000 1.000 502 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), CD3E(1), CD3G(2), ELK1(2), FOS(1), FYN(2), GRB2(3), HRAS(1), JUN(2), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3R1(5), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PTPN7(1), RAF1(5), RASA1(7), RELA(7), SHC1(4), SOS1(7), SYT1(1), VAV1(6), ZAP70(1) 53013224 106 93 100 27 11 18 10 31 35 1 0.539 1.000 1.000 503 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(3), TDO2(1), TPH1(3), WARS(1), WARS2(1) 63371849 115 93 112 29 18 13 16 45 22 1 0.216 1.000 1.000 504 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT2(1), CDS2(1), CHAT(5), CHKB(2), CHPT1(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), ESCO1(4), ESCO2(1), ETNK1(3), ETNK2(2), GPAM(5), GPD1(2), GPD1L(3), GPD2(2), LCAT(5), LYPLA1(1), PCYT1A(2), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PNPLA3(3), PPAP2B(2), PPAP2C(3), PTDSS1(2), PTDSS2(1), SH3GLB1(3) 77494873 110 92 106 28 15 16 12 31 36 0 0.260 1.000 1.000 505 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(1), AKT2(4), AKT3(2), BRD4(6), CBL(2), CDC42(1), CDKN2A(4), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), LNPEP(4), MAPK1(1), MAPK3(3), PARD3(7), PDK1(1), PIK3CD(2), PIK3R1(5), PTPN1(2), RAF1(5), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(2), SOS1(7), SOS2(7), YWHAB(1) 62256135 102 92 98 26 12 12 18 33 27 0 0.283 1.000 1.000 506 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(1), AKT2(4), AKT3(2), BCR(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), PDK1(1), PITX2(2), PLCG2(3), PPP1R13B(6), PREX1(9), PTPRC(7), RPS6KA3(2), RPS6KB1(2), SAG(5), SYK(2), TEC(5), VAV1(6) 59843946 103 91 103 26 8 17 14 37 27 0 0.208 1.000 1.000 507 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(3), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), GCK(1), IL1R1(3), JUN(2), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK10(2), MAPK7(1), MAPK9(2), NFATC3(8), NR2C2(1), PAPPA(5), SHC1(4), TRAF6(2), ZAK(5) 57720004 101 91 98 28 7 10 12 43 28 1 0.676 1.000 1.000 508 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), CYP19A1(2), HSD11B1(1), HSD11B2(1), HSD17B1(2), HSD17B2(1), HSD17B8(2), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6) 57945032 100 90 100 25 6 8 22 32 32 0 0.378 1.000 1.000 509 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAS1(5), ALAS2(3), BLVRA(1), COX10(5), COX15(4), CP(4), EPRS(3), FECH(2), FTH1(1), FTMT(5), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UROD(1) 48220294 102 90 100 30 9 9 20 41 23 0 0.659 1.000 1.000 510 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(1), ASAH1(2), ATF1(2), BRAF(6), CREB1(1), CREB5(3), CREBBP(13), DAG1(3), EGR2(1), EGR3(2), EGR4(2), ELK1(2), FRS2(3), JUN(2), MAP1B(12), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(6), PIK3C2G(5), PIK3CD(2), PIK3R1(5), PTPN11(1), RPS6KA3(2), SHC1(4), SRC(2), TERF2IP(1), TH(4) 56314386 104 89 101 30 13 21 12 35 22 1 0.320 1.000 1.000 511 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CSK(4), DAG1(3), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), LYN(3), MAP2K2(1), MAPK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6) 58617900 99 87 99 22 12 14 15 39 19 0 0.104 1.000 1.000 512 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(5), CARS(6), CARS2(3), DARS(4), DARS2(1), EPRS(3), FARSA(3), HARS(1), HARS2(1), IARS(4), IARS2(6), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), MTFMT(1), NARS2(6), PARS2(4), QARS(4), RARS(4), RARS2(2), SARS(2), TARS(6), TARS2(5), VARS(3), VARS2(6), WARS(1), WARS2(1), YARS(1), YARS2(1) 62976054 104 85 100 29 3 15 14 44 28 0 0.659 1.000 1.000 513 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(2), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GBGT1(3), GCNT2(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 56439467 104 85 98 29 11 17 10 32 33 1 0.569 1.000 1.000 514 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1) 59303740 98 85 97 44 9 20 18 28 23 0 0.985 1.000 1.000 515 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1) 59303740 98 85 97 44 9 20 18 28 23 0 0.985 1.000 1.000 516 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GAPDHS(4), GCK(1), GOT1(3), GOT2(3), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(1) 49444447 99 84 94 28 7 11 14 22 44 1 0.697 1.000 1.000 517 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(1), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CPT1B(1), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), MAOA(2), MAOB(3), PISD(1), PLCB2(5), PLCG1(3), PLCG2(3), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6) 49604167 87 83 83 22 9 11 16 23 27 1 0.314 1.000 1.000 518 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(3), BCAR1(5), BCR(2), CAPN1(2), CSK(4), FYN(2), GRB2(3), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAPK1(1), MAPK3(3), PPP1R12B(3), PTK2(3), PXN(3), RAF1(5), RAP1A(1), ROCK1(7), SHC1(4), SOS1(7), SRC(2), TLN1(12), VCL(3), ZYX(1) 55077457 96 83 95 28 8 12 7 42 26 1 0.664 1.000 1.000 519 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(11), ASAH1(2), CAV3(1), DAG1(3), DLG4(1), EPHB2(3), GNAI1(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PITX2(2), RHO(1), RYR1(23) 53654839 88 83 88 24 14 12 13 32 17 0 0.282 1.000 1.000 520 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 CALM2(1), ELK1(2), FCER1A(1), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP2K7(3), MAP3K1(8), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PAK2(4), PIK3R1(5), PLA2G4A(2), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6) 47336039 95 82 92 30 12 12 10 33 28 0 0.779 1.000 1.000 521 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(1), AKT2(4), AKT3(2), ARHGEF11(6), CDC42(1), DLG4(1), GNA13(6), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(6), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RDX(2), ROCK1(7), ROCK2(3), TBXA2R(4) 58459367 96 82 92 33 9 8 11 40 28 0 0.878 1.000 1.000 522 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), DAO(1), GATM(2), GLUD1(1), GOT1(3), GOT2(3), MAOA(2), MAOB(3), NOS1(10), NOS3(3), OAT(3), ODC1(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(4), SMS(2) 51006592 89 81 89 22 9 6 17 28 29 0 0.385 1.000 1.000 523 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(8), CREBBP(13), EP300(16), ERCC3(3), GRIP1(5), GTF2A1(3), GTF2E1(1), GTF2F1(2), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), MEF2C(1), NCOR2(7), NRIP1(6), PELP1(1), POLR2A(11), TBP(2) 54844927 89 80 85 47 6 9 16 30 28 0 0.998 1.000 1.000 524 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), CEL(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), GK(2), GLA(1), GLB1(5), LCT(5), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PPAP2B(2), PPAP2C(3) 55879071 94 80 93 26 14 13 11 30 26 0 0.303 1.000 1.000 525 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1) 56046010 91 79 84 26 9 7 12 28 34 1 0.716 1.000 1.000 526 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPAT2(1), AGPS(2), CDS2(1), CHAT(5), CHKB(2), CLC(2), CPT1B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), ETNK1(3), GPD1(2), GPD2(2), LCAT(5), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PISD(1), PLA2G4A(2), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(3), PPAP2B(2), PPAP2C(3) 59037628 91 79 88 26 16 15 10 22 28 0 0.335 1.000 1.000 527 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1) 56046010 91 79 84 26 9 7 12 28 34 1 0.716 1.000 1.000 528 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(8), AKR1B1(3), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 53655297 90 79 88 24 6 10 17 22 33 2 0.568 1.000 1.000 529 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(3), CAMK1G(4), ELK1(2), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NCF1(1), NCF2(2), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3C2G(5), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), RELA(7), SYT1(1) 45257365 92 78 86 25 10 10 8 30 33 1 0.707 1.000 1.000 530 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(8), ESR2(5), HNF4A(3), NPM1(2), NR1D2(2), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(7), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(4), PPARD(1), PPARG(3), RARA(4), RARB(2), RARG(1), ROR1(1), RORA(4), RORC(2), RXRA(2), RXRB(5), RXRG(2), THRA(2), VDR(2) 46611617 81 78 81 28 10 12 17 27 15 0 0.743 1.000 1.000 531 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(3), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(2), LHCGR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NPY1R(2), NPY2R(3), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAC4(1), TACR1(1), TACR2(1), TACR3(2), TRHR(2), TSHR(3) 59524154 93 78 93 30 15 12 13 39 14 0 0.483 1.000 1.000 532 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(23), ATR(11), BRCA1(8), BRCA2(10), CHEK1(1), CHEK2(3), FANCA(6), FANCD2(1), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(4), RAD17(2), RAD50(4), RAD51(2), TREX1(3) 51232955 87 76 86 22 6 15 11 35 20 0 0.471 1.000 1.000 533 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(4), BTG1(3), CBX3(1), CLOCK(2), CRY1(1), EIF4G2(4), ETV6(2), HERPUD1(2), HSPA8(9), IDI1(1), KLF9(2), MYF6(5), NCKAP1(2), NCOA4(6), NR1D2(2), PER1(8), PER2(6), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), SUMO3(1), TOB1(4), UGP2(1), ZFR(7) 42750817 79 76 78 31 4 9 14 31 20 1 0.951 1.000 1.000 534 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(3), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(1), CDC42(1), CFL1(1), CFL2(1), FLNA(5), FLNC(7), FSCN1(3), FSCN2(1), FSCN3(2), GDI2(2), LIMK1(6), MYH2(9), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PFN1(1), RHO(1), ROCK1(7), ROCK2(3), WASF1(1) 54254322 88 76 86 27 8 16 4 26 34 0 0.669 1.000 1.000 535 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), ACTR3(1), AKT1(1), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), MAPK1(1), MAPK3(3), NR1I3(1), PAK1(4), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CD(2), PIK3R1(5), RIPK3(1) 55098898 84 76 84 27 10 13 11 32 18 0 0.594 1.000 1.000 536 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), CALM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK14(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6) 44321389 85 75 82 25 9 11 10 29 26 0 0.702 1.000 1.000 537 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(2), F12(9), F13B(3), F2(4), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), LPA(9), PLAT(4), PLG(6), SERPINF2(2), VWF(15) 41598065 90 75 86 34 10 7 15 27 29 2 0.883 1.000 1.000 538 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(3), CDC7(1), CDK2(2), CDT1(2), DIAPH2(3), MCM10(3), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), PCNA(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(2), RFC5(2), RPA1(2), RPA2(2), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(6) 55282392 87 75 84 23 10 12 11 32 22 0 0.333 1.000 1.000 539 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CFLAR(3), DAXX(6), DFFA(1), DFFB(1), FAF1(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), PTPN13(10), RB1(4), RIPK2(2), SPTAN1(11) 49731360 85 72 85 27 5 6 16 28 28 2 0.790 1.000 1.000 540 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), DOCK1(2), ELK1(2), FOS(1), GAB1(1), GRB2(3), HGF(2), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(3), PAK1(4), PIK3R1(5), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAF1(5), RAP1A(1), RASA1(7), SOS1(7), SRC(2), STAT3(4) 46027410 83 71 82 24 7 19 7 25 25 0 0.628 1.000 1.000 541 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), ATF2(3), CALM2(1), EGFR(10), ELK1(2), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK1(1), MAPK3(3), MEF2A(2), MEF2C(1), MEF2D(1), PAK1(4), PRKCA(3), PTK2(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1) 39915866 78 70 76 22 8 14 9 28 19 0 0.487 1.000 1.000 542 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3B(3), POLR3E(1), POLR3H(2), POLR3K(1), TAF12(1), TAF5(2), TAF6(2), TAF7(2), TAF9(1), TBP(2) 41759952 77 70 73 26 3 9 9 25 31 0 0.833 1.000 1.000 543 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), B4GALT5(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), OGT(6), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(4) 38238278 72 68 69 26 5 7 12 29 19 0 0.892 1.000 1.000 544 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(1), DAXX(6), ELK1(2), GRB2(3), HRAS(1), HSPB2(3), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK14(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(2), RIPK1(2), RPS6KA5(3), SHC1(4), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 43430632 79 67 77 21 8 8 7 35 21 0 0.565 1.000 1.000 545 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), FLT1(8), FLT4(15), HIF1A(5), HRAS(1), KDR(6), NOS3(3), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PXN(3), SHC1(4) 37280009 74 67 73 23 12 7 8 20 26 1 0.764 1.000 1.000 546 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MIOX(2), OCRL(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3) 50543648 75 66 74 28 5 7 8 28 27 0 0.970 1.000 1.000 547 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), RB1(4), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 46308681 76 66 76 25 3 7 15 24 25 2 0.822 1.000 1.000 548 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(4), BAX(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(2), JUN(2), MAP3K1(8), MAPK10(2), MCL1(1), MYC(1), NFKB1(1), NFKBIA(1), PARP1(6), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(9), TRADD(2), TRAF2(1) 42907120 74 65 68 21 1 12 11 26 23 1 0.673 1.000 1.000 549 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(6), ATM(23), BRCA1(8), CDKN1A(3), CHEK1(1), CHEK2(3), JUN(2), MRE11A(4), NFKB1(1), NFKBIA(1), RAD50(4), RAD51(2), RBBP8(2), RELA(7), TP73(4) 33833618 71 65 67 20 5 10 7 27 20 2 0.716 1.000 1.000 550 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(2), ADCY3(5), ADCY9(8), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), GNAS(5), PDIA4(2), PLCG1(3), PLCG2(3), PRKCA(3), SEC61B(1), TRIM23(3) 43700456 71 65 70 25 2 8 11 28 22 0 0.941 1.000 1.000 551 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(8), ACAT1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(3), ALDH2(4), ALDH3A2(3), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 42151190 72 65 71 19 5 8 13 21 24 1 0.520 1.000 1.000 552 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(2), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GANC(4), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH12(3), RDH13(1), UGP2(1) 44936912 72 63 71 22 7 10 8 24 23 0 0.703 1.000 1.000 553 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), BID(2), BIRC2(3), BIRC3(6), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DFFA(1), DFFB(1), GAS2(3), LMNA(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF10B(1), TNFSF10(9), TRADD(2), TRAF2(1) 39279854 70 62 64 18 1 8 13 23 24 1 0.482 1.000 1.000 554 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(3), AKR1B10(2), ALDOA(2), ALDOB(5), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(1), RDH11(4), RDH12(3), RDH13(1), TPI1(1) 43121493 67 62 66 19 10 8 11 21 17 0 0.491 1.000 1.000 555 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GHR(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JAK2(7), MAPK1(1), MAPK3(3), PIK3R1(5), PLCG1(3), PRKCA(3), PTPN6(3), RAF1(5), SHC1(4), SLC2A4(3), SOCS1(1), SOS1(7), STAT5A(4), STAT5B(4) 34387383 69 61 65 19 8 8 10 23 20 0 0.645 1.000 1.000 556 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(4), ASAH1(2), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SGMS1(1), SGPP1(3), SMPD1(5), SMPD2(3), SMPD3(2), SMPD4(2), SPHK1(1), SPHK2(2), SPTLC1(3), SPTLC2(1), UGT8(1) 40831951 69 61 64 25 12 13 6 20 18 0 0.711 1.000 1.000 557 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(5), CALM2(1), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), PAK1(4), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1) 33410221 63 58 62 21 5 10 5 25 17 1 0.909 1.000 1.000 558 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(13), EP300(16), FYN(2), IL7R(1), JAK1(6), JAK3(4), LCK(1), PIK3R1(5), PTK2B(4), STAT5A(4), STAT5B(4) 30425331 60 56 56 17 4 6 12 16 22 0 0.689 1.000 1.000 559 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), APAF1(4), ATM(23), BAX(1), BID(2), CASP6(1), CASP7(1), CASP9(2), PRKCA(3), PTK2(3), PXN(3), STAT1(6), TLN1(12) 31291868 62 55 61 19 5 7 5 21 24 0 0.754 1.000 1.000 560 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(1), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(4), HDAC5(3), IGF1R(4), INS(1), INSR(4), MAPK14(2), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NFATC1(4), NFATC2(6), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYT1(1) 37829578 61 55 56 21 10 5 5 20 21 0 0.825 1.000 1.000 561 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 BLVRA(1), CP(4), EPRS(3), FECH(2), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UROD(1) 31445852 59 55 59 19 5 5 14 19 16 0 0.738 1.000 1.000 562 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(2), CDC42(1), CREB1(1), CREB5(3), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(2), IL1R1(3), MAP2K3(3), MAP3K10(4), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), MKNK1(2), MKNK2(2), NFKB1(1), NR2C2(1), TRAF6(2) 39499446 58 55 58 15 5 12 4 25 12 0 0.427 1.000 1.000 563 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(3), GTF2B(2), GTF2E1(1), GTF2F1(2), NCOA1(5), NCOA2(13), NCOA3(8), NCOR2(7), POLR2A(11), RARA(4), RXRA(2), TBP(2) 29423543 63 54 56 30 4 8 8 17 26 0 0.979 1.000 1.000 564 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(1), GNAI1(3), GNB1(3), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), PLA2G4A(2), PLCB1(3), PRKCA(3), PTGS1(2), PTK2(3), RAF1(5), SRC(2), SYK(2), TBXAS1(4) 28684455 58 53 57 21 7 8 7 15 20 1 0.833 1.000 1.000 565 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(3), CAPN1(2), ITGA1(8), ITGB1(6), ITGB3(4), PTK2(3), PXN(3), SPTAN1(11), SRC(2), TLN1(12) 33627479 56 53 55 23 4 7 4 20 21 0 0.963 1.000 1.000 566 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSB(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), HSD11B1(1), HSD11B2(1), HSD17B2(1), HSD17B8(2), HSD3B1(1), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4) 31910844 56 52 56 17 3 4 12 15 22 0 0.630 1.000 1.000 567 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(2), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TLR10(3), TLR2(3), TLR3(2), TLR4(2), TLR6(2), TLR7(5), TLR9(1), TRAF6(2) 42857531 59 52 55 16 4 10 3 22 19 1 0.641 1.000 1.000 568 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(1), GNAS(5), GNB1(3), HRAS(1), LIMK1(6), MAPK1(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2(3), RAF1(5), ROCK2(3) 29986422 54 51 50 20 4 4 6 20 20 0 0.971 1.000 1.000 569 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(2), AKT1(1), ASAH1(2), GNAI1(3), GNB1(3), ITGAV(2), ITGB3(4), MAPK1(1), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCB1(3), PRKCA(3), PTK2(3), SMPD1(5), SMPD2(3), SPHK1(1), SRC(2) 29626034 52 50 50 23 9 9 3 16 15 0 0.960 1.000 1.000 570 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(6), DARS(4), EPRS(3), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), QARS(4), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(1), YARS(1) 37940598 57 49 54 16 1 4 10 24 18 0 0.744 1.000 1.000 571 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(5), CXCR4(1), GNAI1(3), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), PIK3C2G(5), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PTK2B(4), PXN(3), RAF1(5), RELA(7) 30352982 56 49 52 27 4 8 4 20 18 2 0.998 1.000 1.000 572 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 DLG4(1), EPHB2(3), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(3), MAPK1(1), MAPK7(1), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RAF1(5), SRC(2), TEC(5), VAV1(6) 30599233 52 49 50 18 7 4 6 23 12 0 0.808 1.000 1.000 573 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKM(3), PFKP(3), PGM1(1) 37943653 54 48 53 22 4 8 5 15 22 0 0.968 1.000 1.000 574 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(6), GNAI1(3), GNB1(3), MAP3K7(3), PIK3R1(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2B(4), ROCK1(7) 27603726 52 48 52 16 8 5 3 21 15 0 0.779 1.000 1.000 575 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM2(1), CAPN2(3), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SYT1(1) 28178328 54 47 49 23 7 4 5 16 22 0 0.985 1.000 1.000 576 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(9), APOA1(1), CYP7A1(1), HMGCR(1), LCAT(5), LDLR(4), LIPC(1), LPL(6), LRP1(15), SCARB1(1), SOAT1(5) 31848173 49 47 47 15 5 8 5 16 15 0 0.576 1.000 1.000 577 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKL(3), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TALDO1(1), TKT(3), TKTL1(2), TKTL2(4) 28308157 48 46 45 15 5 10 7 11 15 0 0.681 1.000 1.000 578 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRA2A(1), ADRB2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), DRD1(1), DRD2(2), DRD3(3), DRD5(3), HRH2(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2) 29179700 49 45 47 23 8 4 3 21 13 0 0.937 1.000 1.000 579 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 BAIAP2(3), CASP1(2), CASP7(1), CASP8(1), GAPDH(3), INS(1), INSR(4), ITCH(1), MAGI1(5), MAGI2(4), RERE(10), WWP1(7), WWP2(4) 25497549 46 44 41 18 7 2 7 16 13 1 0.979 1.000 1.000 580 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2) 37066754 47 44 47 12 10 6 3 21 7 0 0.328 1.000 1.000 581 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), BIRC2(3), BIRC3(6), CASP8(1), CFLAR(3), JUN(2), MAP3K3(3), MAP3K7(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(3), RIPK1(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1) 31902512 46 44 46 14 4 8 8 19 7 0 0.463 1.000 1.000 582 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(13), DAXX(6), HRAS(1), PAX3(2), PML(3), RARA(4), RB1(4), SIRT1(5), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2) 20841711 44 43 44 14 5 4 7 14 12 2 0.718 1.000 1.000 583 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), BCAR1(5), CSK(4), CTNNA1(9), CTNNA2(7), CTNNB1(4), PTK2(3), PXN(3), SRC(2), VCL(3) 22456638 44 42 44 21 5 5 6 18 9 1 0.973 1.000 1.000 584 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(8), DDX20(8), E2F1(1), ETS1(3), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(3), SIN3A(4), SIN3B(4) 30929306 46 42 45 16 7 5 3 19 12 0 0.723 1.000 1.000 585 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(1), ARSE(4), ASAH1(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SMPD1(5), SMPD2(3), SPTLC1(3), SPTLC2(1) 27802355 46 42 44 20 8 8 4 14 12 0 0.885 1.000 1.000 586 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 AKR1B1(3), ALDOA(2), ALDOB(5), FPGT(1), GCK(1), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1), TPI1(1) 27480682 44 41 43 18 5 5 8 10 16 0 0.943 1.000 1.000 587 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(4), AP2M1(1), ARF1(1), EEA1(7), GRASP(1), GSK3A(1), GSK3B(3), LYN(3), PFKL(3), PFKM(3), PFKP(3), PLCG1(3), PRKCE(4), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4) 29563551 46 41 43 17 4 6 7 15 14 0 0.865 1.000 1.000 588 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), P4HB(2), SLC23A1(6), SLC23A2(2), SLC2A1(1), SLC2A3(2) 30108246 45 41 45 16 4 16 2 13 10 0 0.784 1.000 1.000 589 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(3), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SP1(2), SP3(3), SYT1(1) 23924009 44 39 41 16 4 5 5 9 20 1 0.940 1.000 1.000 590 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(6), GALNT2(2), GALNT4(4), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(4) 17269460 40 39 37 21 2 2 6 15 15 0 0.996 1.000 1.000 591 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TAL1(3), TALDO1(1), TKT(3) 23519618 42 39 39 14 3 8 7 10 14 0 0.806 1.000 1.000 592 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(2), CASP2(1), CHUK(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(3), MAP3K1(8), MAP4K2(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 28736215 43 39 40 12 2 5 4 16 15 1 0.809 1.000 1.000 593 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(4), AP2M1(1), BIN1(3), CALM2(1), DNM1(2), EPN1(1), EPS15(1), PICALM(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYNJ1(5), SYNJ2(6), SYT1(1) 26162782 38 38 38 13 1 6 7 14 10 0 0.734 1.000 1.000 594 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(2), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B1(1), HSD11B2(1), PLA2G4A(2), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(5), TBXAS1(4) 24838875 40 38 40 20 4 5 6 15 9 1 0.961 1.000 1.000 595 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(23), ATR(11), CDC25C(4), CHEK1(1), CHEK2(3) 17976254 42 36 41 12 3 6 5 14 14 0 0.713 1.000 1.000 596 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(2), AKT1(1), BAX(1), CSF2RB(7), IGF1R(4), IL3(1), KITLG(2), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 22998535 35 34 35 14 8 3 2 14 8 0 0.775 1.000 1.000 597 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), AGPS(2), CHPT1(2), ENPP2(3), ENPP6(1), PAFAH1B1(2), PAFAH1B2(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PPAP2B(2), PPAP2C(3) 27618832 37 34 35 16 8 4 3 14 8 0 0.887 1.000 1.000 598 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(16), MAPK1(1), MAPK3(3), PELP1(1), SRC(2) 17397310 36 33 33 16 3 4 8 8 13 0 0.929 1.000 1.000 599 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), NPAS2(1), PER1(8), PER2(6), PER3(7) 19953118 32 32 30 13 4 1 6 12 9 0 0.896 1.000 1.000 600 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(6), JAK2(7), JAK3(4), PIAS3(3), PTPRU(6), SRC(2), STAT3(4) 17886898 36 32 36 11 2 5 5 14 10 0 0.755 1.000 1.000 601 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(7), JAK3(4), MAPK1(1), MAPK3(3), STAT3(4), TYK2(7) 13832210 32 32 31 11 3 1 8 11 9 0 0.863 1.000 1.000 602 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(1), DPM2(1), GRB2(3), HRAS(1), NTRK1(6), PIK3R1(5), PLCG1(3), PRKCA(3), SHC1(4), SOS1(7) 15637139 34 32 32 12 2 7 2 13 10 0 0.846 1.000 1.000 603 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), CREB1(1), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(6), PIK3R1(5), PLCG1(3), SHC1(4) 18232277 33 30 31 13 5 3 3 14 8 0 0.862 1.000 1.000 604 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 22 AMT(1), ASNS(2), CA1(1), CA12(1), CA13(2), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), HAL(1) 22786965 31 30 31 11 2 3 2 19 5 0 0.869 1.000 1.000 605 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(1), CHRNB1(4), MUSK(3), PIK3R1(5), PTK2(3), PTK2B(4), SRC(2), TERT(10) 16781538 32 29 32 11 4 10 1 10 7 0 0.596 1.000 1.000 606 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(2), ASPH(1), COPS5(2), CREB1(1), EP300(16), HIF1A(5), JUN(2), NOS3(3), P4HB(2) 19541982 34 29 31 13 1 0 4 10 18 1 0.959 1.000 1.000 607 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(5), FASN(8), MCAT(2), OLAH(2), OXSM(3) 18489296 28 28 28 11 3 4 4 11 6 0 0.762 1.000 1.000 608 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(2), GRM1(5), PLCB1(3), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4) 18749854 27 27 27 14 5 1 2 9 10 0 0.925 1.000 1.000 609 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 20 AMT(1), ASNS(2), CA1(1), CA12(1), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS2(4), GLUD1(1), GLUL(2), HAL(1) 20917218 28 27 28 10 1 2 2 18 5 0 0.883 1.000 1.000 610 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR1(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(3), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(3), VAMP1(2), VAMP2(1), VTI1A(1), VTI1B(1) 19768357 24 24 24 12 2 6 2 9 5 0 0.867 1.000 1.000 611 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(5), SRC(2), UBQLN1(3) 14487126 21 21 21 10 2 4 5 7 2 1 0.875 1.000 1.000 612 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(3), B3GAT2(1), B3GAT3(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST3(2), CHST7(1), DSE(1), XYLT1(4), XYLT2(2) 13652136 21 21 21 10 5 5 1 6 4 0 0.804 1.000 1.000 613 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR2(5), ITPKA(1), PDE1A(1), PDE1B(6), PLCB1(3), PLCB2(5) 12464123 21 21 21 12 6 2 1 6 6 0 0.967 1.000 1.000 614 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(1), PIK3R1(5), PLCB1(3), PLCG1(3), PRKCA(3), VAV1(6) 12648037 21 20 20 12 4 4 2 3 8 0 0.978 1.000 1.000 615 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(1) 9619204 19 19 17 10 1 1 3 10 4 0 0.962 1.000 1.000 616 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 10 ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), CDC42(1), WASF1(1) 7696881 7 7 7 4 0 3 0 4 0 0 0.922 1.000 1.000