E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.101 -9999.0 0.0 -0.509 22.0 22.0 KLHL20 -0.013 0.046 -9999.0 0.0 -0.35 2.0 2.0 CYFIP2 0.004 0.092 -9999.0 0.0 -0.742 8.0 8.0 Rac1/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.021 0.101 -9999.0 0.0 -0.509 22.0 22.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.01 0.047 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.036 -9999.0 0.0 -0.215 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.084 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.053 0.099 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.106 -9999.0 0.0 -0.533 22.0 22.0 CRK 0.042 0.107 -9999.0 0.0 -0.469 22.0 22.0 E-cadherin/gamma catenin/alpha catenin -0.022 0.103 -9999.0 0.0 -0.49 24.0 24.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.021 0.101 -9999.0 0.0 -0.509 22.0 22.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.035 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.002 0.03 -9999.0 0.0 -0.483 2.0 2.0 PI3K -0.01 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.026 0.121 -9999.0 0.0 -0.575 24.0 24.0 TIAM1 0.014 0.033 -9999.0 0.0 -0.741 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.017 0.08 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 CDH1 -0.016 0.151 -9999.0 0.0 -0.741 22.0 22.0 RhoA/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.01 0.034 -9999.0 0.0 -0.245 2.0 2.0 CDC42/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.068 -9999.0 0.0 -0.32 24.0 24.0 ITGB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.017 0.084 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.017 0.082 -9999.0 0.0 -0.411 22.0 22.0 mol:GDP 0.063 0.087 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.057 -9999.0 0.0 -0.742 3.0 3.0 p120 catenin/RhoA/GDP -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.035 0.063 -9999.0 0.0 -0.263 20.0 20.0 NME1 0.014 0.038 -9999.0 0.0 -0.862 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.101 -9999.0 0.0 -0.509 22.0 22.0 regulation of cell-cell adhesion -0.009 0.041 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.011 0.054 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.018 0.086 -9999.0 0.0 -0.803 1.0 1.0 CCND1 -0.016 0.065 -9999.0 0.0 -0.333 20.0 20.0 VAV2 0.049 0.104 -9999.0 0.0 -0.5 1.0 1.0 RAP1/GDP -0.011 0.056 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.032 0.109 -9999.0 0.0 -0.492 22.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.017 0.081 -9999.0 0.0 -0.767 1.0 1.0 E-cadherin/beta catenin -0.019 0.09 -9999.0 0.0 -0.452 22.0 22.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.101 -9999.0 0.0 -0.509 22.0 22.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 Rac1/GTP -0.021 0.072 -9999.0 0.0 -0.6 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.019 0.094 -9999.0 0.0 -0.472 22.0 22.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.109 -9999.0 0.0 -0.546 22.0 22.0