Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	207.0	15764.0	76.0	-1.33	0.026	1000.0	-1000.0	-0.172	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	188.0	6418.0	34.0	-0.605	0.016	1000.0	-1000.0	-0.094	-1000.0
TCGA08_p53	146.0	1027.0	7.0	-0.652	0.313	1000.0	-1000.0	-0.024	-1000.0
TCR signaling in naïve CD8+ T cells	144.0	13457.0	93.0	-0.655	0.328	1000.0	-1000.0	-0.107	-1000.0
TCGA08_retinoblastoma	132.0	1060.0	8.0	-0.841	0.217	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	121.0	5602.0	46.0	-1.219	0.025	1000.0	-1000.0	-0.087	-1000.0
Aurora B signaling	121.0	8115.0	67.0	-0.404	0.016	1000.0	-1000.0	-0.108	-1000.0
Syndecan-4-mediated signaling events	120.0	8066.0	67.0	-0.638	0.108	1000.0	-1000.0	-0.13	-1000.0
Glypican 1 network	113.0	5458.0	48.0	-0.557	0.045	1000.0	-1000.0	-0.072	-1000.0
IL12-mediated signaling events	107.0	9364.0	87.0	-0.69	0.162	1000.0	-1000.0	-0.169	-1000.0
FOXM1 transcription factor network	106.0	5453.0	51.0	-0.823	0.04	1000.0	-1000.0	-0.201	-1000.0
PDGFR-alpha signaling pathway	104.0	4618.0	44.0	-0.274	0.034	1000.0	-1000.0	-0.09	-1000.0
amb2 Integrin signaling	85.0	6997.0	82.0	-0.55	0.016	1000.0	-1000.0	-0.121	-1000.0
IL4-mediated signaling events	79.0	7222.0	91.0	-0.838	0.544	1000.0	-1000.0	-0.164	-1000.0
JNK signaling in the CD4+ TCR pathway	77.0	1318.0	17.0	-0.412	0.016	1000.0	-1000.0	-0.096	-1000.0
EGFR-dependent Endothelin signaling events	74.0	1567.0	21.0	-0.666	0.016	1000.0	-1000.0	-0.104	-1000.0
Caspase cascade in apoptosis	73.0	5428.0	74.0	-0.325	0.161	1000.0	-1000.0	-0.076	-1000.0
Aurora C signaling	71.0	499.0	7.0	-0.393	0.012	1000.0	-1000.0	-0.062	-1000.0
Glypican 2 network	70.0	281.0	4.0	-0.123	-1000.0	1000.0	-1000.0	-0.052	-1000.0
Syndecan-1-mediated signaling events	69.0	2354.0	34.0	-0.413	0.016	1000.0	-1000.0	-0.095	-1000.0
BMP receptor signaling	64.0	5249.0	81.0	-0.689	0.016	1000.0	-1000.0	-0.129	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	60.0	2012.0	33.0	-0.83	0.016	1000.0	-1000.0	-0.091	-1000.0
IL23-mediated signaling events	58.0	3481.0	60.0	-0.392	0.021	1000.0	-1000.0	-0.2	-1000.0
HIF-2-alpha transcription factor network	53.0	2315.0	43.0	-0.76	0.34	1000.0	-1000.0	-0.122	-1000.0
Signaling events mediated by the Hedgehog family	51.0	2665.0	52.0	-0.436	0.118	1000.0	-1000.0	-0.119	-1000.0
IL27-mediated signaling events	45.0	2305.0	51.0	-0.622	0.074	1000.0	-1000.0	-0.109	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	45.0	3076.0	68.0	-0.545	0.063	1000.0	-1000.0	-0.164	-1000.0
Fc-epsilon receptor I signaling in mast cells	44.0	4361.0	97.0	-0.32	0.04	1000.0	-1000.0	-0.136	-1000.0
Ephrin A  reverse signaling	41.0	292.0	7.0	-0.059	-0.0	1000.0	-1000.0	-0.038	-1000.0
Effects of Botulinum toxin	41.0	1091.0	26.0	-0.363	0.016	1000.0	-1000.0	-0.094	-1000.0
Arf6 signaling events	39.0	2465.0	62.0	-0.666	0.016	1000.0	-1000.0	-0.092	-1000.0
Calcium signaling in the CD4+ TCR pathway	39.0	1222.0	31.0	-0.455	0.016	1000.0	-1000.0	-0.147	-1000.0
VEGFR1 specific signals	38.0	2132.0	56.0	-0.467	0.046	1000.0	-1000.0	-0.119	-1000.0
p75(NTR)-mediated signaling	36.0	4553.0	125.0	-0.414	0.016	1000.0	-1000.0	-0.148	-1000.0
LPA4-mediated signaling events	34.0	417.0	12.0	-0.165	0.026	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	34.0	1996.0	58.0	-0.432	0.032	1000.0	-1000.0	-0.119	-1000.0
IL2 signaling events mediated by STAT5	34.0	752.0	22.0	-0.435	0.038	1000.0	-1000.0	-0.059	-1000.0
BCR signaling pathway	32.0	3216.0	99.0	-0.343	0.035	1000.0	-1000.0	-0.141	-1000.0
Coregulation of Androgen receptor activity	31.0	2358.0	76.0	-0.915	0.033	1000.0	-1000.0	-0.075	-1000.0
PLK1 signaling events	31.0	2652.0	85.0	-0.376	0.016	1000.0	-1000.0	-0.078	-1000.0
S1P1 pathway	30.0	1090.0	36.0	-0.378	0.018	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	30.0	2356.0	78.0	-0.316	0.045	1000.0	-1000.0	-0.106	-1000.0
Glucocorticoid receptor regulatory network	29.0	3337.0	114.0	-0.408	0.162	1000.0	-1000.0	-0.11	-1000.0
IL6-mediated signaling events	29.0	2213.0	75.0	-0.287	0.076	1000.0	-1000.0	-0.117	-1000.0
Regulation of Telomerase	29.0	2984.0	102.0	-0.667	0.051	1000.0	-1000.0	-0.155	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	28.0	1523.0	54.0	-0.65	0.031	1000.0	-1000.0	-0.148	-1000.0
Integrins in angiogenesis	27.0	2319.0	84.0	-0.378	0.04	1000.0	-1000.0	-0.143	-1000.0
Angiopoietin receptor Tie2-mediated signaling	24.0	2112.0	88.0	-0.312	0.075	1000.0	-1000.0	-0.156	-1000.0
Visual signal transduction: Rods	24.0	1274.0	52.0	-0.288	0.016	1000.0	-1000.0	-0.124	-1000.0
Signaling events mediated by PTP1B	23.0	1810.0	76.0	-0.669	0.049	1000.0	-1000.0	-0.112	-1000.0
Aurora A signaling	22.0	1362.0	60.0	-0.238	0.053	1000.0	-1000.0	-0.091	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	22.0	1007.0	45.0	-0.566	0.062	1000.0	-1000.0	-0.136	-1000.0
Syndecan-2-mediated signaling events	21.0	1454.0	69.0	-0.55	0.053	1000.0	-1000.0	-0.097	-1000.0
EPO signaling pathway	21.0	1195.0	55.0	-0.286	0.018	1000.0	-1000.0	-0.139	-1000.0
Endothelins	21.0	2061.0	96.0	-0.347	0.086	1000.0	-1000.0	-0.112	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	20.0	2408.0	120.0	-0.164	0.141	1000.0	-1000.0	-0.118	-1000.0
Regulation of nuclear SMAD2/3 signaling	18.0	2483.0	136.0	-0.452	0.1	1000.0	-1000.0	-0.114	-1000.0
Reelin signaling pathway	18.0	1053.0	56.0	-0.238	0.016	1000.0	-1000.0	-0.13	-1000.0
Wnt signaling	18.0	127.0	7.0	-0.068	0.016	1000.0	-1000.0	-0.079	-1000.0
Presenilin action in Notch and Wnt signaling	17.0	1039.0	61.0	-0.187	0.092	1000.0	-1000.0	-0.1	-1000.0
FoxO family signaling	17.0	1136.0	64.0	-0.569	0.122	1000.0	-1000.0	-0.097	-1000.0
S1P3 pathway	17.0	720.0	42.0	-0.374	0.062	1000.0	-1000.0	-0.08	-1000.0
Thromboxane A2 receptor signaling	16.0	1714.0	105.0	-0.666	0.067	1000.0	-1000.0	-0.106	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	16.0	610.0	37.0	-0.294	0.026	1000.0	-1000.0	-0.12	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	426.0	28.0	-0.138	0.023	1000.0	-1000.0	-0.084	-1000.0
Ceramide signaling pathway	15.0	1161.0	76.0	-0.666	0.232	1000.0	-1000.0	-0.118	-1000.0
LPA receptor mediated events	15.0	1605.0	102.0	-0.398	0.06	1000.0	-1000.0	-0.133	-1000.0
PLK2 and PLK4 events	14.0	44.0	3.0	-0.016	0.011	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	14.0	970.0	68.0	-0.373	0.018	1000.0	-1000.0	-0.135	-1000.0
Canonical Wnt signaling pathway	14.0	735.0	51.0	-0.186	0.096	1000.0	-1000.0	-0.082	-1000.0
Class I PI3K signaling events	14.0	1025.0	73.0	-0.472	0.036	1000.0	-1000.0	-0.109	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	13.0	646.0	47.0	-0.422	0.028	1000.0	-1000.0	-0.064	-1000.0
Regulation of Androgen receptor activity	13.0	924.0	70.0	-0.957	0.04	1000.0	-1000.0	-0.103	-1000.0
ErbB4 signaling events	12.0	837.0	69.0	-0.179	0.105	1000.0	-1000.0	-0.118	-1000.0
Noncanonical Wnt signaling pathway	12.0	312.0	26.0	-0.115	0.016	1000.0	-1000.0	-0.127	-1000.0
Nongenotropic Androgen signaling	12.0	661.0	52.0	-0.177	0.071	1000.0	-1000.0	-0.08	-1000.0
S1P5 pathway	11.0	197.0	17.0	-0.138	0.046	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1485.0	125.0	-0.39	0.043	1000.0	-1000.0	-0.149	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	850.0	74.0	-0.666	0.099	1000.0	-1000.0	-0.132	-1000.0
S1P4 pathway	11.0	287.0	25.0	-0.138	0.033	1000.0	-1000.0	-0.076	-1000.0
Visual signal transduction: Cones	9.0	362.0	38.0	-0.041	0.016	1000.0	-1000.0	-0.095	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	-0.02	0.016	1000.0	-1000.0	-0.055	-1000.0
TCGA08_rtk_signaling	9.0	238.0	26.0	-0.276	0.041	1000.0	-1000.0	-0.031	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	692.0	82.0	-0.064	0.025	1000.0	-1000.0	-0.123	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PRL	7.0	245.0	34.0	-0.055	0.045	1000.0	-1000.0	-0.08	-1000.0
Canonical NF-kappaB pathway	6.0	268.0	39.0	-0.187	0.075	1000.0	-1000.0	-0.119	-1000.0
Signaling events mediated by HDAC Class III	6.0	242.0	40.0	-0.058	0.032	1000.0	-1000.0	-0.067	-1000.0
IL1-mediated signaling events	6.0	400.0	62.0	-0.09	0.059	1000.0	-1000.0	-0.142	-1000.0
Ephrin B reverse signaling	6.0	318.0	48.0	-0.03	0.031	1000.0	-1000.0	-0.107	-1000.0
p38 MAPK signaling pathway	6.0	276.0	44.0	-0.099	0.049	1000.0	-1000.0	-0.089	-1000.0
ErbB2/ErbB3 signaling events	5.0	377.0	65.0	-0.128	0.059	1000.0	-1000.0	-0.097	-1000.0
Arf6 downstream pathway	5.0	225.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.059	-1000.0
Insulin-mediated glucose transport	5.0	190.0	32.0	-0.083	0.068	1000.0	-1000.0	-0.102	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	85.0	15.0	0.0	0.036	1000.0	-1000.0	-0.054	-1000.0
Syndecan-3-mediated signaling events	5.0	209.0	35.0	-0.039	0.016	1000.0	-1000.0	-0.097	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	430.0	76.0	-0.026	0.067	1000.0	-1000.0	-0.124	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	370.0	85.0	-0.037	0.079	1000.0	-1000.0	-0.101	-1000.0
EPHB forward signaling	4.0	370.0	85.0	-0.075	0.069	1000.0	-1000.0	-0.141	-1000.0
Plasma membrane estrogen receptor signaling	4.0	379.0	86.0	-0.163	0.07	1000.0	-1000.0	-0.114	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	84.0	17.0	-0.037	0.055	1000.0	-1000.0	-0.068	-1000.0
BARD1 signaling events	3.0	216.0	57.0	-0.166	0.044	1000.0	-1000.0	-0.105	-1000.0
Osteopontin-mediated events	3.0	118.0	38.0	-0.03	0.096	1000.0	-1000.0	-0.155	-1000.0
Cellular roles of Anthrax toxin	3.0	119.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.043	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	108.0	36.0	-0.026	0.031	1000.0	-1000.0	-0.097	-1000.0
PDGFR-beta signaling pathway	3.0	293.0	97.0	-0.058	0.087	1000.0	-1000.0	-0.131	-1000.0
E-cadherin signaling in keratinocytes	3.0	149.0	43.0	-0.291	0.054	1000.0	-1000.0	-0.107	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	141.0	65.0	-0.06	0.093	1000.0	-1000.0	-0.091	-1000.0
ceramide signaling pathway	2.0	131.0	49.0	-0.116	0.054	1000.0	-1000.0	-0.078	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	130.0	52.0	-0.031	0.093	1000.0	-1000.0	-0.087	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	179.0	83.0	-0.083	0.081	1000.0	-1000.0	-0.107	-1000.0
Signaling events mediated by HDAC Class I	2.0	212.0	104.0	-0.029	0.063	1000.0	-1000.0	-0.108	-1000.0
Retinoic acid receptors-mediated signaling	2.0	125.0	58.0	-0.025	0.062	1000.0	-1000.0	-0.117	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	101.0	44.0	-0.046	0.049	1000.0	-1000.0	-0.078	-1000.0
Regulation of p38-alpha and p38-beta	2.0	154.0	54.0	-0.041	0.073	1000.0	-1000.0	-0.082	-1000.0
Arf6 trafficking events	2.0	192.0	71.0	-0.123	0.058	1000.0	-1000.0	-0.103	-1000.0
Insulin Pathway	2.0	201.0	74.0	-0.034	0.055	1000.0	-1000.0	-0.133	-1000.0
Signaling events mediated by HDAC Class II	1.0	127.0	75.0	-0.027	0.051	1000.0	-1000.0	-0.087	-1000.0
Circadian rhythm pathway	1.0	22.0	22.0	-0.019	0.064	1000.0	-1000.0	-0.097	-1000.0
mTOR signaling pathway	1.0	67.0	53.0	-0.01	0.044	1000.0	-1000.0	-0.088	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	103.0	68.0	-0.083	0.059	1000.0	-1000.0	-0.097	-1000.0
Nectin adhesion pathway	1.0	96.0	63.0	-0.016	0.078	1000.0	-1000.0	-0.109	-1000.0
Atypical NF-kappaB pathway	1.0	55.0	31.0	-0.02	0.037	1000.0	-1000.0	-0.114	-1000.0
IGF1 pathway	1.0	110.0	57.0	-0.065	0.071	1000.0	-1000.0	-0.134	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.062	1000.0	-1000.0	-0.103	-1000.0
TRAIL signaling pathway	0.0	29.0	48.0	-0.002	0.07	1000.0	-1000.0	-0.081	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.077	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.006	0.016	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	31.0	54.0	-0.01	0.043	1000.0	-1000.0	-0.058	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.005	0.016	1000.0	-1000.0	-0.098	-1000.0
Total	3986	219370	7203	-39.8860234341	-991.853868918	131000	-131000	-13.4387951318	-131000