E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.124 -9999.0 0.0 -0.478 17.0 17.0 KLHL20 0.022 0.075 0.209 2.0 -0.32 2.0 4.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.635 7.0 7.0 Rac1/GDP 0.024 0.087 0.304 4.0 -9999.0 0.0 4.0 ENAH -0.02 0.123 -9999.0 0.0 -0.479 18.0 18.0 AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.028 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.034 -9999.0 0.0 -0.202 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.082 -9999.0 0.0 -0.367 14.0 14.0 RAPGEF1 -0.011 0.121 0.273 4.0 -0.429 12.0 16.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.13 -9999.0 0.0 -0.495 18.0 18.0 CRK -0.01 0.12 -9999.0 0.0 -0.449 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.089 -9999.0 0.0 -0.425 16.0 16.0 alphaE/beta7 Integrin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.02 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.018 0.12 -9999.0 0.0 -0.479 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.05 0.025 -9999.0 0.0 -0.336 1.0 1.0 PI3K -0.007 0.037 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.102 -9999.0 0.0 -0.492 19.0 19.0 TIAM1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.031 0.073 -9999.0 0.0 -0.343 14.0 14.0 AKT1 0.021 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.03 -9999.0 0.0 -0.635 1.0 1.0 CDH1 0.007 0.119 -9999.0 0.0 -0.618 18.0 18.0 RhoA/GDP 0.041 0.085 0.341 9.0 -9999.0 0.0 9.0 actin cytoskeleton organization 0.023 0.062 0.174 15.0 -0.226 2.0 17.0 CDC42/GDP 0.032 0.107 0.371 15.0 -9999.0 0.0 15.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.063 -9999.0 0.0 -0.303 16.0 16.0 ITGB7 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.034 0.078 -9999.0 0.0 -0.363 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.02 0.068 -9999.0 0.0 -0.345 14.0 14.0 mol:GDP 0.021 0.115 0.439 10.0 -0.4 3.0 13.0 CDC42/GTP/IQGAP1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.05 -9999.0 0.0 -0.635 3.0 3.0 p120 catenin/RhoA/GDP 0.019 0.081 0.308 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.062 0.168 15.0 -0.218 18.0 33.0 NME1 0.028 0.027 -9999.0 0.0 -0.59 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.022 0.125 -9999.0 0.0 -0.484 17.0 17.0 regulation of cell-cell adhesion 0.013 0.042 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.03 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.034 0.066 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.087 -9999.0 0.0 -0.661 1.0 1.0 CCND1 0.021 0.073 0.204 8.0 -0.273 18.0 26.0 VAV2 -0.017 0.16 -9999.0 0.0 -0.56 16.0 16.0 RAP1/GDP 0.043 0.077 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.021 0.121 -9999.0 0.0 -0.468 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.048 0.091 -9999.0 0.0 -0.636 1.0 1.0 E-cadherin/beta catenin -0.0 0.078 -9999.0 0.0 -0.407 18.0 18.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.123 -9999.0 0.0 -0.475 17.0 17.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 Rac1/GTP -0.031 0.078 -9999.0 0.0 -0.402 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.023 0.079 -9999.0 0.0 -0.4 14.0 14.0 ITGAE 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.132 -9999.0 0.0 -0.507 18.0 18.0