Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.18 0.193 -9999.0 0.0 -0.584 32.0 32.0 IHH -0.08 0.192 -9999.0 0.0 -0.687 44.0 44.0 SHH Np/Cholesterol/GAS1 0.004 0.098 -9999.0 0.0 -0.372 30.0 30.0 LRPAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.097 0.37 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.085 0.148 -9999.0 0.0 -0.519 25.0 25.0 SMO -0.096 0.147 -9999.0 0.0 -0.538 25.0 25.0 AKT1 -0.034 0.109 -9999.0 0.0 -0.543 10.0 10.0 ARRB2 0.028 0.032 -9999.0 0.0 -0.707 1.0 1.0 BOC 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.145 -9999.0 0.0 -0.53 25.0 25.0 STIL -0.069 0.133 -9999.0 0.0 -0.522 6.0 6.0 DHH N/PTCH2 0.008 0.124 -9999.0 0.0 -0.444 36.0 36.0 DHH N/PTCH1 -0.105 0.152 -9999.0 0.0 -0.501 32.0 32.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 DHH 0.014 0.099 -9999.0 0.0 -0.635 12.0 12.0 PTHLH -0.28 0.271 -9999.0 0.0 -0.808 37.0 37.0 determination of left/right symmetry -0.094 0.145 -9999.0 0.0 -0.53 25.0 25.0 PIK3R1 0.026 0.03 -9999.0 0.0 -0.635 1.0 1.0 skeletal system development -0.278 0.269 -9999.0 0.0 -0.799 37.0 37.0 IHH N/Hhip -0.161 0.252 -9999.0 0.0 -0.533 156.0 156.0 DHH N/Hhip -0.093 0.228 -9999.0 0.0 -0.478 133.0 133.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.145 -9999.0 0.0 -0.53 25.0 25.0 pancreas development -0.132 0.282 -9999.0 0.0 -0.621 130.0 130.0 HHAT 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.035 -9999.0 0.0 -0.472 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.15 -9999.0 0.0 -0.585 32.0 32.0 somite specification -0.094 0.145 -9999.0 0.0 -0.53 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.082 0.128 -9999.0 0.0 -0.443 26.0 26.0 SHH Np/Cholesterol/PTCH2 0.007 0.091 -9999.0 0.0 -0.344 31.0 31.0 SHH Np/Cholesterol/Megalin -0.004 0.117 -9999.0 0.0 -0.405 36.0 36.0 SHH 0.011 0.068 -9999.0 0.0 -0.469 10.0 10.0 catabolic process -0.121 0.155 -9999.0 0.0 -0.521 32.0 32.0 SMO/Vitamin D3 -0.084 0.138 -9999.0 0.0 -0.488 26.0 26.0 SHH Np/Cholesterol/Hhip -0.068 0.175 -9999.0 0.0 -0.382 116.0 116.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.591 43.0 43.0 receptor-mediated endocytosis -0.096 0.162 -9999.0 0.0 -0.647 17.0 17.0 SHH Np/Cholesterol/BOC 0.022 0.056 -9999.0 0.0 -0.364 10.0 10.0 SHH Np/Cholesterol/CDO -0.015 0.121 -9999.0 0.0 -0.341 61.0 61.0 mesenchymal cell differentiation 0.068 0.174 0.379 116.0 -9999.0 0.0 116.0 mol:Vitamin D3 -0.076 0.137 -9999.0 0.0 -0.448 26.0 26.0 IHH N/PTCH2 -0.057 0.162 -9999.0 0.0 -0.464 67.0 67.0 CDON -0.04 0.196 -9999.0 0.0 -0.59 59.0 59.0 IHH N/PTCH1 -0.122 0.158 -9999.0 0.0 -0.527 32.0 32.0 Megalin/LRPAP1 0.004 0.131 -9999.0 0.0 -0.47 35.0 35.0 PTCH2 -0.001 0.132 -9999.0 0.0 -0.59 25.0 25.0 SHH Np/Cholesterol 0.011 0.053 -9999.0 0.0 -0.368 10.0 10.0 PTCH1 -0.122 0.156 -9999.0 0.0 -0.522 32.0 32.0 HHIP -0.132 0.282 -9999.0 0.0 -0.622 130.0 130.0