Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.058 -9999.0 0.0 -0.406 3.0 3.0 epithelial cell differentiation 0.027 0.071 -9999.0 0.0 -0.34 14.0 14.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.635 7.0 7.0 ENAH 0.062 0.102 0.391 17.0 -9999.0 0.0 17.0 EGFR 0.02 0.067 -9999.0 0.0 -0.597 6.0 6.0 EPHA2 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 MYO6 0.058 0.11 0.383 13.0 -0.476 2.0 15.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.058 -9999.0 0.0 -0.401 7.0 7.0 AQP5 -0.105 0.238 -9999.0 0.0 -0.511 108.0 108.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.062 0.107 0.395 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion 0.052 0.118 0.405 11.0 -0.46 1.0 12.0 EGF -0.566 0.198 -9999.0 0.0 -0.63 474.0 474.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.007 0.159 -9999.0 0.0 -0.546 30.0 30.0 cortical microtubule organization 0.027 0.071 -9999.0 0.0 -0.34 14.0 14.0 GO:0000145 0.052 0.106 0.387 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.073 -9999.0 0.0 -0.343 14.0 14.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.041 -9999.0 0.0 -0.356 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.041 0.084 0.375 2.0 -9999.0 0.0 2.0 PVRL2 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.048 0.094 0.36 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.069 0.044 -9999.0 0.0 -0.34 2.0 2.0 CDH1 0.007 0.119 -9999.0 0.0 -0.618 18.0 18.0 EGFR/EGFR/EGF/EGF -0.242 0.144 -9999.0 0.0 -0.589 19.0 19.0 RhoA/GDP 0.029 0.068 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.051 0.103 0.346 12.0 -0.446 2.0 14.0 IGF-1R heterotetramer 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.023 0.06 -9999.0 0.0 -0.59 5.0 5.0 DIAPH1 0.032 0.107 -9999.0 0.0 -0.667 7.0 7.0 Wnt receptor signaling pathway -0.027 0.071 0.34 14.0 -9999.0 0.0 14.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.048 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.051 0.104 0.349 12.0 -0.459 2.0 14.0 EFNA1 0.027 0.028 -9999.0 0.0 -0.59 1.0 1.0 LPP 0.046 0.095 0.39 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.023 0.065 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.001 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.053 0.119 0.407 11.0 -0.468 1.0 12.0 HGF/MET 0.012 0.09 -9999.0 0.0 -0.595 3.0 3.0 HGF 0.003 0.12 -9999.0 0.0 -0.597 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.058 -9999.0 0.0 -0.41 3.0 3.0 actin cable formation 0.106 0.13 0.333 73.0 -9999.0 0.0 73.0 KIAA1543 0.048 0.107 0.355 10.0 -0.528 2.0 12.0 KIFC3 0.051 0.094 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.052 0.101 0.43 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.04 0.025 -9999.0 0.0 -0.472 1.0 1.0 mol:GDP 0.027 0.071 -9999.0 0.0 -0.34 14.0 14.0 EXOC4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.051 0.092 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.062 0.108 0.397 13.0 -9999.0 0.0 13.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.075 0.112 0.411 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.071 0.136 0.507 16.0 -0.711 2.0 18.0 IGF-1R heterotetramer/IGF1 0.022 0.069 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.039 -9999.0 0.0 -0.59 2.0 2.0 PLEKHA7 0.057 0.109 0.362 10.0 -0.555 2.0 12.0 mol:GTP 0.063 0.04 -9999.0 0.0 -0.354 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.083 0.127 0.38 50.0 -9999.0 0.0 50.0 cortical actin cytoskeleton stabilization 0.013 0.058 -9999.0 0.0 -0.406 3.0 3.0 regulation of cell-cell adhesion 0.051 0.103 0.346 12.0 -0.446 2.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.058 -9999.0 0.0 -0.41 3.0 3.0