Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	248.0	8465.0	34.0	-0.513	0.03	1000.0	-1000.0	-0.052	-1000.0
HIF-1-alpha transcription factor network	178.0	13558.0	76.0	-1.109	0.045	1000.0	-1000.0	-0.157	-1000.0
TCGA08_retinoblastoma	171.0	1375.0	8.0	-0.578	0.16	1000.0	-1000.0	-0.007	-1000.0
TCGA08_p53	158.0	1111.0	7.0	-0.422	0.223	1000.0	-1000.0	-0.015	-1000.0
EGFR-dependent Endothelin signaling events	142.0	2989.0	21.0	-0.566	0.043	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	140.0	13059.0	93.0	-0.436	0.204	1000.0	-1000.0	-0.076	-1000.0
PDGFR-alpha signaling pathway	115.0	5067.0	44.0	-0.225	0.037	1000.0	-1000.0	-0.056	-1000.0
FOXA2 and FOXA3 transcription factor networks	114.0	5280.0	46.0	-1.097	0.036	1000.0	-1000.0	-0.127	-1000.0
Syndecan-4-mediated signaling events	94.0	6336.0	67.0	-0.432	0.089	1000.0	-1000.0	-0.067	-1000.0
Aurora B signaling	93.0	6262.0	67.0	-0.259	0.042	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	90.0	7883.0	87.0	-0.445	0.113	1000.0	-1000.0	-0.133	-1000.0
Glypican 1 network	85.0	4095.0	48.0	-0.401	0.046	1000.0	-1000.0	-0.039	-1000.0
FOXM1 transcription factor network	79.0	4039.0	51.0	-0.565	0.031	1000.0	-1000.0	-0.126	-1000.0
amb2 Integrin signaling	74.0	6085.0	82.0	-0.451	0.038	1000.0	-1000.0	-0.054	-1000.0
BMP receptor signaling	71.0	5798.0	81.0	-0.525	0.054	1000.0	-1000.0	-0.084	-1000.0
Aurora C signaling	69.0	486.0	7.0	-0.26	0.027	1000.0	-1000.0	-0.019	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	65.0	2158.0	33.0	-0.571	0.056	1000.0	-1000.0	-0.056	-1000.0
Glypican 2 network	63.0	253.0	4.0	-0.041	-1000.0	1000.0	-1000.0	0.001	-1000.0
IL4-mediated signaling events	61.0	5581.0	91.0	-0.789	0.491	1000.0	-1000.0	-0.124	-1000.0
Caspase cascade in apoptosis	56.0	4189.0	74.0	-0.292	0.093	1000.0	-1000.0	-0.047	-1000.0
Syndecan-1-mediated signaling events	53.0	1824.0	34.0	-0.251	0.03	1000.0	-1000.0	-0.063	-1000.0
JNK signaling in the CD4+ TCR pathway	51.0	869.0	17.0	-0.223	0.03	1000.0	-1000.0	-0.052	-1000.0
Fc-epsilon receptor I signaling in mast cells	48.0	4685.0	97.0	-0.231	0.04	1000.0	-1000.0	-0.088	-1000.0
HIF-2-alpha transcription factor network	41.0	1799.0	43.0	-0.527	0.249	1000.0	-1000.0	-0.072	-1000.0
Effects of Botulinum toxin	39.0	1021.0	26.0	-0.232	0.04	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	38.0	2407.0	62.0	-0.566	0.065	1000.0	-1000.0	-0.05	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1151.0	31.0	-0.369	0.029	1000.0	-1000.0	-0.071	-1000.0
Coregulation of Androgen receptor activity	36.0	2788.0	76.0	-0.855	0.055	1000.0	-1000.0	-0.031	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	36.0	1953.0	54.0	-0.441	0.041	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1852.0	52.0	-0.28	0.068	1000.0	-1000.0	-0.064	-1000.0
Reelin signaling pathway	35.0	1997.0	56.0	-0.173	0.079	1000.0	-1000.0	-0.066	-1000.0
IL27-mediated signaling events	34.0	1742.0	51.0	-0.605	0.059	1000.0	-1000.0	-0.069	-1000.0
Ephrin A  reverse signaling	33.0	232.0	7.0	-0.026	0.012	1000.0	-1000.0	-0.019	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2266.0	68.0	-0.329	0.059	1000.0	-1000.0	-0.111	-1000.0
PLK1 signaling events	32.0	2770.0	85.0	-0.185	0.042	1000.0	-1000.0	-0.038	-1000.0
LPA4-mediated signaling events	31.0	383.0	12.0	-0.104	0.011	1000.0	-1000.0	-0.028	-1000.0
IL2 signaling events mediated by STAT5	31.0	702.0	22.0	-0.291	0.036	1000.0	-1000.0	-0.066	-1000.0
p75(NTR)-mediated signaling	29.0	3674.0	125.0	-0.301	0.079	1000.0	-1000.0	-0.108	-1000.0
S1P1 pathway	29.0	1052.0	36.0	-0.247	0.029	1000.0	-1000.0	-0.062	-1000.0
Integrins in angiogenesis	27.0	2284.0	84.0	-0.266	0.067	1000.0	-1000.0	-0.068	-1000.0
IL23-mediated signaling events	26.0	1560.0	60.0	-0.259	0.029	1000.0	-1000.0	-0.123	-1000.0
BCR signaling pathway	25.0	2482.0	99.0	-0.223	0.057	1000.0	-1000.0	-0.096	-1000.0
IL2 signaling events mediated by PI3K	24.0	1444.0	58.0	-0.289	0.047	1000.0	-1000.0	-0.055	-1000.0
VEGFR1 specific signals	24.0	1370.0	56.0	-0.315	0.03	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by PTP1B	23.0	1764.0	76.0	-0.569	0.065	1000.0	-1000.0	-0.057	-1000.0
Glucocorticoid receptor regulatory network	23.0	2706.0	114.0	-0.336	0.15	1000.0	-1000.0	-0.081	-1000.0
Wnt signaling	23.0	162.0	7.0	-0.042	0.028	1000.0	-1000.0	-0.034	-1000.0
Ceramide signaling pathway	22.0	1723.0	76.0	-0.566	0.206	1000.0	-1000.0	-0.059	-1000.0
Regulation of Telomerase	22.0	2274.0	102.0	-0.567	0.062	1000.0	-1000.0	-0.086	-1000.0
Angiopoietin receptor Tie2-mediated signaling	22.0	1960.0	88.0	-0.203	0.046	1000.0	-1000.0	-0.086	-1000.0
FoxO family signaling	21.0	1357.0	64.0	-0.556	0.095	1000.0	-1000.0	-0.057	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	21.0	983.0	45.0	-0.365	0.078	1000.0	-1000.0	-0.083	-1000.0
Visual signal transduction: Rods	21.0	1142.0	52.0	-0.157	0.04	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	21.0	1654.0	78.0	-0.246	0.046	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	19.0	509.0	26.0	-0.098	0.029	1000.0	-1000.0	-0.071	-1000.0
Syndecan-2-mediated signaling events	19.0	1320.0	69.0	-0.451	0.063	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	18.0	1040.0	55.0	-0.168	0.036	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2198.0	120.0	-0.109	0.081	1000.0	-1000.0	-0.076	-1000.0
Endothelins	17.0	1653.0	96.0	-0.329	0.048	1000.0	-1000.0	-0.076	-1000.0
IL6-mediated signaling events	17.0	1348.0	75.0	-0.225	0.06	1000.0	-1000.0	-0.058	-1000.0
Regulation of nuclear SMAD2/3 signaling	16.0	2259.0	136.0	-0.295	0.1	1000.0	-1000.0	-0.06	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	1004.0	61.0	-0.139	0.084	1000.0	-1000.0	-0.063	-1000.0
LPA receptor mediated events	16.0	1657.0	102.0	-0.247	0.052	1000.0	-1000.0	-0.079	-1000.0
Thromboxane A2 receptor signaling	15.0	1630.0	105.0	-0.566	0.047	1000.0	-1000.0	-0.065	-1000.0
Aurora A signaling	15.0	904.0	60.0	-0.147	0.063	1000.0	-1000.0	-0.041	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	15.0	1141.0	74.0	-0.566	0.106	1000.0	-1000.0	-0.093	-1000.0
Class I PI3K signaling events	15.0	1128.0	73.0	-0.314	0.08	1000.0	-1000.0	-0.062	-1000.0
IFN-gamma pathway	14.0	969.0	68.0	-0.242	0.043	1000.0	-1000.0	-0.091	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	14.0	518.0	37.0	-0.172	0.058	1000.0	-1000.0	-0.048	-1000.0
Canonical Wnt signaling pathway	14.0	723.0	51.0	-0.139	0.098	1000.0	-1000.0	-0.071	-1000.0
S1P5 pathway	13.0	223.0	17.0	-0.079	0.029	1000.0	-1000.0	-0.037	-1000.0
Nongenotropic Androgen signaling	13.0	715.0	52.0	-0.116	0.045	1000.0	-1000.0	-0.049	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1135.0	86.0	-0.147	0.053	1000.0	-1000.0	-0.093	-1000.0
Regulation of Androgen receptor activity	13.0	962.0	70.0	-0.911	0.054	1000.0	-1000.0	-0.059	-1000.0
Sphingosine 1-phosphate (S1P) pathway	12.0	348.0	28.0	-0.079	0.048	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	0.006	0.026	1000.0	-1000.0	-0.025	-1000.0
Signaling events regulated by Ret tyrosine kinase	12.0	1030.0	82.0	-0.03	0.03	1000.0	-1000.0	-0.097	-1000.0
S1P3 pathway	12.0	528.0	42.0	-0.245	0.051	1000.0	-1000.0	-0.058	-1000.0
ErbB4 signaling events	11.0	826.0	69.0	-0.161	0.095	1000.0	-1000.0	-0.063	-1000.0
FAS signaling pathway (CD95)	11.0	555.0	47.0	-0.279	0.049	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1402.0	125.0	-0.244	0.044	1000.0	-1000.0	-0.079	-1000.0
TCGA08_rtk_signaling	11.0	291.0	26.0	-0.225	0.057	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	11.0	294.0	25.0	-0.079	0.039	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling events	11.0	57.0	5.0	0.007	0.026	1000.0	-1000.0	-0.013	-1000.0
Syndecan-3-mediated signaling events	10.0	363.0	35.0	-0.011	0.079	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	0.01	0.029	1000.0	-1000.0	-0.004	-1000.0
ceramide signaling pathway	9.0	467.0	49.0	-0.064	0.045	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Cones	8.0	318.0	38.0	-0.013	0.044	1000.0	-1000.0	-0.029	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	663.0	85.0	-0.038	0.082	1000.0	-1000.0	-0.069	-1000.0
Ephrin B reverse signaling	7.0	375.0	48.0	-0.047	0.052	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by PRL	7.0	248.0	34.0	-0.044	0.063	1000.0	-1000.0	-0.059	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.021	0.021	1000.0	-1000.0	-0.005	-1000.0
Canonical NF-kappaB pathway	6.0	267.0	39.0	-0.113	0.057	1000.0	-1000.0	-0.059	-1000.0
Insulin-mediated glucose transport	6.0	192.0	32.0	-0.041	0.057	1000.0	-1000.0	-0.037	-1000.0
mTOR signaling pathway	6.0	324.0	53.0	-0.064	0.054	1000.0	-1000.0	-0.059	-1000.0
IL1-mediated signaling events	6.0	376.0	62.0	-0.041	0.065	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	493.0	76.0	-0.031	0.05	1000.0	-1000.0	-0.091	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	106.0	17.0	-0.01	0.054	1000.0	-1000.0	-0.038	-1000.0
ErbB2/ErbB3 signaling events	5.0	339.0	65.0	-0.124	0.042	1000.0	-1000.0	-0.062	-1000.0
Cellular roles of Anthrax toxin	5.0	220.0	39.0	-0.01	0.039	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class III	5.0	232.0	40.0	-0.054	0.054	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	75.0	15.0	-0.0	0.03	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	246.0	44.0	-0.042	0.053	1000.0	-1000.0	-0.051	-1000.0
EPHB forward signaling	5.0	437.0	85.0	-0.054	0.073	1000.0	-1000.0	-0.102	-1000.0
PDGFR-beta signaling pathway	5.0	511.0	97.0	-0.019	0.087	1000.0	-1000.0	-0.087	-1000.0
p38 MAPK signaling pathway	5.0	253.0	44.0	-0.063	0.057	1000.0	-1000.0	-0.048	-1000.0
Regulation of p38-alpha and p38-beta	4.0	263.0	54.0	-0.022	0.067	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	4.0	310.0	74.0	-0.032	0.08	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling in keratinocytes	4.0	212.0	43.0	-0.218	0.042	1000.0	-1000.0	-0.064	-1000.0
BARD1 signaling events	3.0	207.0	57.0	-0.095	0.076	1000.0	-1000.0	-0.071	-1000.0
Osteopontin-mediated events	3.0	120.0	38.0	-0.0	0.085	1000.0	-1000.0	-0.062	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	227.0	65.0	-0.005	0.104	1000.0	-1000.0	-0.067	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	234.0	68.0	-0.041	0.055	1000.0	-1000.0	-0.05	-1000.0
Nectin adhesion pathway	3.0	192.0	63.0	-0.0	0.057	1000.0	-1000.0	-0.067	-1000.0
Arf6 trafficking events	3.0	252.0	71.0	-0.115	0.063	1000.0	-1000.0	-0.064	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	127.0	52.0	-0.015	0.1	1000.0	-1000.0	-0.054	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	223.0	83.0	-0.041	0.074	1000.0	-1000.0	-0.063	-1000.0
Retinoic acid receptors-mediated signaling	2.0	119.0	58.0	-0.015	0.053	1000.0	-1000.0	-0.063	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	75.0	36.0	-0.052	0.054	1000.0	-1000.0	-0.061	-1000.0
Atypical NF-kappaB pathway	2.0	62.0	31.0	-0.0	0.037	1000.0	-1000.0	-0.044	-1000.0
IGF1 pathway	2.0	126.0	57.0	-0.048	0.078	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by HDAC Class II	1.0	116.0	75.0	-0.041	0.062	1000.0	-1000.0	-0.044	-1000.0
Circadian rhythm pathway	1.0	25.0	22.0	-0.014	0.069	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	1.0	183.0	104.0	-0.057	0.076	1000.0	-1000.0	-0.059	-1000.0
Arf1 pathway	1.0	80.0	54.0	-0.0	0.049	1000.0	-1000.0	-0.031	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	-0.027	0.056	1000.0	-1000.0	-0.042	-1000.0
Arf6 downstream pathway	0.0	40.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.045	-1000.0
TRAIL signaling pathway	0.0	32.0	48.0	0.0	0.072	1000.0	-1000.0	-0.057	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.07	1000.0	-1000.0	-0.057	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.008	0.036	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.0	0.062	1000.0	-1000.0	-0.015	-1000.0
Total	3822	202347	7203	-29.752439023	-991.535998032	131000	-131000	-7.90736308455	-131000