Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.099 -9999.0 0.0 -0.236 10.0 10.0 epithelial cell differentiation 0.01 0.107 -9999.0 0.0 -0.215 9.0 9.0 CYFIP2 0.028 0.058 -9999.0 0.0 -0.43 1.0 1.0 ENAH 0.014 0.157 0.539 2.0 -0.296 4.0 6.0 EGFR -0.025 0.152 -9999.0 0.0 -0.371 11.0 11.0 EPHA2 0.028 0.07 -9999.0 0.0 -0.365 2.0 2.0 MYO6 0.035 0.146 0.271 8.0 -0.231 8.0 16.0 CTNNB1 0.033 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.061 -9999.0 0.0 -0.256 1.0 1.0 AQP5 0.019 0.154 -9999.0 0.0 -0.651 2.0 2.0 CTNND1 0.023 0.096 -9999.0 0.0 -0.43 3.0 3.0 mol:PI-4-5-P2 0.034 0.143 0.269 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.165 0.207 7.0 -0.304 11.0 18.0 EGF -0.127 0.196 -9999.0 0.0 -0.342 31.0 31.0 NCKAP1 0.036 0.042 -9999.0 0.0 -0.301 1.0 1.0 AQP3 -0.019 0.202 -9999.0 0.0 -0.641 5.0 5.0 cortical microtubule organization 0.01 0.107 -9999.0 0.0 -0.215 9.0 9.0 GO:0000145 0.02 0.136 0.255 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.111 -9999.0 0.0 -0.217 9.0 9.0 MLLT4 0.032 0.057 -9999.0 0.0 -0.43 1.0 1.0 ARF6/GDP -0.044 0.106 -9999.0 0.0 -0.378 4.0 4.0 ARF6 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.123 -9999.0 0.0 -0.296 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.117 0.211 5.0 -0.261 3.0 8.0 PVRL2 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.116 0.209 6.0 -9999.0 0.0 6.0 ARF6/GTP 0.063 0.121 -9999.0 0.0 -0.313 4.0 4.0 CDH1 -0.022 0.153 -9999.0 0.0 -0.371 11.0 11.0 EGFR/EGFR/EGF/EGF -0.09 0.144 -9999.0 0.0 -0.343 10.0 10.0 RhoA/GDP 0.013 0.105 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.018 0.115 0.191 7.0 -0.39 1.0 8.0 IGF-1R heterotetramer 0.038 0.056 -9999.0 0.0 -0.429 1.0 1.0 GIT1 0.041 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.038 0.056 -9999.0 0.0 -0.43 1.0 1.0 IGF1 -0.017 0.14 -9999.0 0.0 -0.336 11.0 11.0 DIAPH1 0.011 0.195 -9999.0 0.0 -0.656 2.0 2.0 Wnt receptor signaling pathway -0.01 0.107 0.215 9.0 -9999.0 0.0 9.0 RHOA 0.034 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.045 0.106 -9999.0 0.0 -0.377 4.0 4.0 CTNNA1 0.035 0.018 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.018 0.117 0.193 7.0 -0.4 1.0 8.0 EFNA1 -0.008 0.141 -9999.0 0.0 -0.43 7.0 7.0 LPP -0.01 0.133 0.205 5.0 -0.343 3.0 8.0 Ephrin A1/EPHA2 -0.017 0.128 -9999.0 0.0 -0.365 4.0 4.0 SEC6/SEC8 -0.019 0.078 -9999.0 0.0 -0.351 1.0 1.0 MGAT3 -0.027 0.167 0.209 7.0 -0.309 11.0 18.0 HGF/MET -0.006 0.1 -9999.0 0.0 -0.258 1.0 1.0 HGF 0.019 0.089 -9999.0 0.0 -0.333 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.1 -9999.0 0.0 -0.237 10.0 10.0 actin cable formation 0.048 0.18 0.326 10.0 -0.359 3.0 13.0 KIAA1543 0.01 0.112 0.196 7.0 -9999.0 0.0 7.0 KIFC3 0.023 0.119 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.036 0.057 -9999.0 0.0 -0.43 1.0 1.0 EXOC3 0.034 0.057 -9999.0 0.0 -0.43 1.0 1.0 ACTN1 0.001 0.14 0.209 6.0 -0.325 4.0 10.0 NCK1/GIT1 0.054 0.05 -9999.0 0.0 -0.324 1.0 1.0 mol:GDP 0.01 0.107 -9999.0 0.0 -0.215 9.0 9.0 EXOC4 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.015 0.132 -9999.0 0.0 -0.405 2.0 2.0 PIP5K1C 0.034 0.144 0.271 8.0 -9999.0 0.0 8.0 LIMA1 0.017 0.096 -9999.0 0.0 -0.326 5.0 5.0 ABI1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.029 0.175 0.48 3.0 -0.361 3.0 6.0 adherens junction assembly 0.043 0.157 0.949 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.014 0.126 -9999.0 0.0 -0.325 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.052 0.048 -9999.0 0.0 -0.304 1.0 1.0 MET 0.028 0.07 -9999.0 0.0 -0.365 2.0 2.0 PLEKHA7 0.023 0.119 0.209 7.0 -9999.0 0.0 7.0 mol:GTP 0.053 0.121 -9999.0 0.0 -0.294 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.037 0.151 0.384 4.0 -0.506 1.0 5.0 cortical actin cytoskeleton stabilization -0.017 0.099 -9999.0 0.0 -0.236 10.0 10.0 regulation of cell-cell adhesion 0.018 0.115 0.191 7.0 -0.39 1.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.1 -9999.0 0.0 -0.237 10.0 10.0