E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.167 -9999.0 0.0 -0.566 24.0 24.0 KLHL20 -0.014 0.048 -9999.0 0.0 -0.35 1.0 1.0 CYFIP2 0.01 0.048 -9999.0 0.0 -0.807 1.0 1.0 Rac1/GDP 0.025 0.111 -9999.0 0.0 -0.342 24.0 24.0 ENAH -0.01 0.167 -9999.0 0.0 -0.566 24.0 24.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.024 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.033 -9999.0 0.0 -0.224 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.01 0.143 -9999.0 0.0 -0.487 24.0 24.0 RAPGEF1 0.007 0.145 -9999.0 0.0 -0.475 24.0 24.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.162 -9999.0 0.0 -0.588 24.0 24.0 CRK -0.001 0.157 -9999.0 0.0 -0.524 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.044 0.147 -9999.0 0.0 -0.535 24.0 24.0 alphaE/beta7 Integrin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.01 0.167 -9999.0 0.0 -0.566 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.056 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.034 0.176 -9999.0 0.0 -0.618 24.0 24.0 TIAM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.01 0.136 -9999.0 0.0 -0.462 24.0 24.0 AKT1 -0.012 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.055 0.226 -9999.0 0.0 -0.807 24.0 24.0 RhoA/GDP 0.025 0.11 -9999.0 0.0 -0.342 24.0 24.0 actin cytoskeleton organization 0.03 0.048 -9999.0 0.0 -0.244 1.0 1.0 CDC42/GDP 0.025 0.11 -9999.0 0.0 -0.358 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.006 0.1 -9999.0 0.0 -0.338 24.0 24.0 ITGB7 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.01 0.143 -9999.0 0.0 -0.487 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.018 0.135 -9999.0 0.0 -0.469 24.0 24.0 mol:GDP 0.017 0.128 -9999.0 0.0 -0.407 24.0 24.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.029 0.096 -9999.0 0.0 -0.348 24.0 24.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.025 0.036 -9999.0 0.0 -0.292 1.0 1.0 NME1 0.009 0.031 -9999.0 0.0 -0.291 3.0 3.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.167 -9999.0 0.0 -0.566 24.0 24.0 regulation of cell-cell adhesion -0.021 0.069 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.027 0.09 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.038 0.125 -9999.0 0.0 -0.455 24.0 24.0 CCND1 0.028 0.043 -9999.0 0.0 -0.376 1.0 1.0 VAV2 0.005 0.152 -9999.0 0.0 -0.501 24.0 24.0 RAP1/GDP 0.022 0.106 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.008 0.161 -9999.0 0.0 -0.545 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.004 0.131 -9999.0 0.0 -0.432 24.0 24.0 E-cadherin/beta catenin -0.041 0.136 -9999.0 0.0 -0.493 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.167 -9999.0 0.0 -0.566 24.0 24.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.023 0.079 -9999.0 0.0 -0.652 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.044 0.147 -9999.0 0.0 -0.535 24.0 24.0 ITGAE 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.05 0.166 -9999.0 0.0 -0.604 24.0 24.0