Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.005 0.147 -9999.0 0.0 -0.596 3.0 3.0 IHH -0.061 0.251 -9999.0 0.0 -0.826 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.015 0.133 -9999.0 0.0 -0.5 20.0 20.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.015 0.132 0.497 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 0.003 0.162 -9999.0 0.0 -0.569 7.0 7.0 SMO -0.003 0.171 -9999.0 0.0 -0.502 29.0 29.0 AKT1 0.023 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.018 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.002 0.168 -9999.0 0.0 -0.494 29.0 29.0 STIL 0.005 0.135 -9999.0 0.0 -0.443 11.0 11.0 DHH N/PTCH2 -0.026 0.158 -9999.0 0.0 -0.618 19.0 19.0 DHH N/PTCH1 -0.036 0.188 -9999.0 0.0 -0.462 46.0 46.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.042 0.203 -9999.0 0.0 -0.807 19.0 19.0 PTHLH -0.002 0.174 -9999.0 0.0 -0.768 3.0 3.0 determination of left/right symmetry -0.002 0.168 -9999.0 0.0 -0.494 29.0 29.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.002 0.172 -9999.0 0.0 -0.76 3.0 3.0 IHH N/Hhip -0.063 0.209 -9999.0 0.0 -0.583 39.0 39.0 DHH N/Hhip -0.051 0.207 -9999.0 0.0 -0.675 27.0 27.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.002 0.168 -9999.0 0.0 -0.494 29.0 29.0 pancreas development -0.026 0.161 -9999.0 0.0 -0.624 17.0 17.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.036 0.193 -9999.0 0.0 -0.807 17.0 17.0 somite specification -0.002 0.168 -9999.0 0.0 -0.494 29.0 29.0 SHH Np/Cholesterol/PTCH1 0.0 0.137 -9999.0 0.0 -0.389 31.0 31.0 SHH Np/Cholesterol/PTCH2 0.014 0.057 -9999.0 0.0 -0.493 3.0 3.0 SHH Np/Cholesterol/Megalin -0.033 0.164 -9999.0 0.0 -0.514 29.0 29.0 SHH 0.011 0.07 -9999.0 0.0 -0.62 3.0 3.0 catabolic process -0.008 0.158 -9999.0 0.0 -0.483 28.0 28.0 SMO/Vitamin D3 0.001 0.154 -9999.0 0.0 -0.501 9.0 9.0 SHH Np/Cholesterol/Hhip -0.009 0.114 -9999.0 0.0 -0.494 14.0 14.0 LRP2 -0.064 0.238 -9999.0 0.0 -0.807 27.0 27.0 receptor-mediated endocytosis -0.023 0.198 -9999.0 0.0 -0.655 15.0 15.0 SHH Np/Cholesterol/BOC 0.015 0.056 -9999.0 0.0 -0.493 3.0 3.0 SHH Np/Cholesterol/CDO 0.013 0.058 -9999.0 0.0 -0.493 3.0 3.0 mesenchymal cell differentiation 0.009 0.113 0.49 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.003 0.14 -9999.0 0.0 -0.393 31.0 31.0 IHH N/PTCH2 -0.033 0.169 -9999.0 0.0 -0.543 28.0 28.0 CDON 0.008 0.035 -9999.0 0.0 -0.291 4.0 4.0 IHH N/PTCH1 -0.008 0.16 -9999.0 0.0 -0.49 28.0 28.0 Megalin/LRPAP1 -0.041 0.185 -9999.0 0.0 -0.618 27.0 27.0 PTCH2 0.009 0.031 -9999.0 0.0 -0.291 3.0 3.0 SHH Np/Cholesterol -0.008 0.053 -9999.0 0.0 -0.501 3.0 3.0 PTCH1 -0.008 0.158 -9999.0 0.0 -0.485 28.0 28.0 HHIP -0.026 0.161 -9999.0 0.0 -0.625 17.0 17.0