Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.0 0.099 -9999.0 0.0 -0.328 24.0 24.0 epithelial cell differentiation -0.038 0.126 -9999.0 0.0 -0.457 24.0 24.0 CYFIP2 0.01 0.048 -9999.0 0.0 -0.807 1.0 1.0 ENAH 0.034 0.09 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.011 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.002 0.031 -9999.0 0.0 -0.535 1.0 1.0 AQP5 -0.097 0.21 -9999.0 0.0 -0.608 33.0 33.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.127 -9999.0 0.0 -0.426 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.191 -9999.0 0.0 -0.477 44.0 44.0 EGF -0.725 0.245 -9999.0 0.0 -0.807 261.0 261.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.242 0.309 -9999.0 0.0 -0.626 107.0 107.0 cortical microtubule organization -0.038 0.126 -9999.0 0.0 -0.457 24.0 24.0 GO:0000145 -0.003 0.121 -9999.0 0.0 -0.407 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.038 0.127 -9999.0 0.0 -0.462 24.0 24.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.03 0.098 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.122 -9999.0 0.0 -0.398 24.0 24.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 ARF6/GTP -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.055 0.226 -9999.0 0.0 -0.807 24.0 24.0 EGFR/EGFR/EGF/EGF -0.413 0.162 -9999.0 0.0 -0.45 266.0 266.0 RhoA/GDP -0.035 0.118 -9999.0 0.0 -0.428 24.0 24.0 actin cytoskeleton organization 0.004 0.124 -9999.0 0.0 -0.409 24.0 24.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.004 0.117 -9999.0 0.0 -0.807 6.0 6.0 DIAPH1 -0.004 0.039 -9999.0 0.0 -0.651 1.0 1.0 Wnt receptor signaling pathway 0.038 0.126 0.457 24.0 -9999.0 0.0 24.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.1 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.127 -9999.0 0.0 -0.419 24.0 24.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.005 0.124 -9999.0 0.0 -0.407 24.0 24.0 Ephrin A1/EPHA2 -0.035 0.114 -9999.0 0.0 -0.414 24.0 24.0 SEC6/SEC8 -0.031 0.105 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.043 0.195 -9999.0 0.0 -0.487 44.0 44.0 HGF/MET -0.071 0.164 -9999.0 0.0 -0.469 38.0 38.0 HGF -0.037 0.193 -9999.0 0.0 -0.778 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.099 -9999.0 0.0 -0.33 24.0 24.0 actin cable formation 0.051 0.087 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.003 0.126 -9999.0 0.0 -0.407 25.0 25.0 KIFC3 -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.038 0.126 -9999.0 0.0 -0.457 24.0 24.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 PIP5K1C -0.003 0.129 -9999.0 0.0 -0.433 24.0 24.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.028 0.103 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.02 0.119 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.043 0.127 -9999.0 0.0 -0.416 30.0 30.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.025 0.1 -9999.0 0.0 -0.291 36.0 36.0 PLEKHA7 -0.005 0.132 -9999.0 0.0 -0.434 25.0 25.0 mol:GTP -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.024 0.116 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.0 0.099 -9999.0 0.0 -0.328 24.0 24.0 regulation of cell-cell adhesion 0.004 0.124 -9999.0 0.0 -0.409 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.099 -9999.0 0.0 -0.33 24.0 24.0