Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	134.0	4557.0	34.0	-0.601	0.013	1000.0	-1000.0	-0.058	-1000.0
EGFR-dependent Endothelin signaling events	113.0	2382.0	21.0	-0.725	0.019	1000.0	-1000.0	-0.067	-1000.0
Angiopoietin receptor Tie2-mediated signaling	97.0	8554.0	88.0	-0.977	0.084	1000.0	-1000.0	-0.107	-1000.0
Glypican 2 network	79.0	317.0	4.0	-0.121	-1000.0	1000.0	-1000.0	-0.019	-1000.0
FOXA2 and FOXA3 transcription factor networks	69.0	3185.0	46.0	-1.203	0.019	1000.0	-1000.0	-0.113	-1000.0
PDGFR-alpha signaling pathway	66.0	2924.0	44.0	-0.322	0.028	1000.0	-1000.0	-0.059	-1000.0
Thromboxane A2 receptor signaling	51.0	5458.0	105.0	-0.725	0.088	1000.0	-1000.0	-0.058	-1000.0
Glypican 1 network	40.0	1933.0	48.0	-0.415	0.031	1000.0	-1000.0	-0.046	-1000.0
Arf6 signaling events	39.0	2478.0	62.0	-0.725	0.032	1000.0	-1000.0	-0.065	-1000.0
Signaling mediated by p38-alpha and p38-beta	39.0	1718.0	44.0	-0.197	0.013	1000.0	-1000.0	-0.051	-1000.0
BMP receptor signaling	35.0	2861.0	81.0	-0.521	0.019	1000.0	-1000.0	-0.087	-1000.0
Endothelins	35.0	3453.0	96.0	-0.62	0.013	1000.0	-1000.0	-0.082	-1000.0
amb2 Integrin signaling	34.0	2821.0	82.0	-0.47	0.013	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	34.0	2707.0	78.0	-0.337	0.059	1000.0	-1000.0	-0.062	-1000.0
IL4-mediated signaling events	32.0	2986.0	91.0	-0.924	0.569	1000.0	-1000.0	-0.143	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	32.0	4016.0	125.0	-0.164	0.032	1000.0	-1000.0	-0.09	-1000.0
TCGA08_retinoblastoma	32.0	260.0	8.0	-0.229	0.061	1000.0	-1000.0	-0.014	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	31.0	2115.0	68.0	-0.623	0.098	1000.0	-1000.0	-0.112	-1000.0
S1P1 pathway	26.0	951.0	36.0	-0.199	0.013	1000.0	-1000.0	-0.055	-1000.0
FOXM1 transcription factor network	26.0	1327.0	51.0	-0.223	0.023	1000.0	-1000.0	-0.156	-1000.0
Integrins in angiogenesis	25.0	2178.0	84.0	-0.535	0.035	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by PTP1B	22.0	1727.0	76.0	-0.73	0.098	1000.0	-1000.0	-0.08	-1000.0
Effects of Botulinum toxin	22.0	572.0	26.0	-0.231	0.015	1000.0	-1000.0	-0.065	-1000.0
Syndecan-4-mediated signaling events	22.0	1528.0	67.0	-0.447	0.077	1000.0	-1000.0	-0.095	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	22.0	2653.0	120.0	-0.307	0.138	1000.0	-1000.0	-0.072	-1000.0
TCR signaling in naïve CD8+ T cells	20.0	1927.0	93.0	-0.582	0.275	1000.0	-1000.0	-0.076	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	20.0	1536.0	74.0	-0.725	0.051	1000.0	-1000.0	-0.09	-1000.0
Aurora C signaling	19.0	138.0	7.0	-0.132	0.012	1000.0	-1000.0	-0.031	-1000.0
FoxO family signaling	17.0	1128.0	64.0	-0.904	0.09	1000.0	-1000.0	-0.074	-1000.0
LPA4-mediated signaling events	16.0	196.0	12.0	-0.253	0.019	1000.0	-1000.0	-0.019	-1000.0
Ephrin A  reverse signaling	16.0	115.0	7.0	-0.048	-0.0	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	16.0	1838.0	114.0	-0.655	0.174	1000.0	-1000.0	-0.065	-1000.0
Signaling events regulated by Ret tyrosine kinase	16.0	1316.0	82.0	-0.131	0.013	1000.0	-1000.0	-0.073	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1423.0	86.0	-0.17	0.024	1000.0	-1000.0	-0.082	-1000.0
Syndecan-1-mediated signaling events	15.0	541.0	34.0	-0.115	0.013	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by the Hedgehog family	14.0	772.0	52.0	-0.064	0.023	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling events	14.0	72.0	5.0	-0.055	0.013	1000.0	-1000.0	-0.04	-1000.0
Aurora B signaling	14.0	986.0	67.0	-0.309	0.013	1000.0	-1000.0	-0.065	-1000.0
Coregulation of Androgen receptor activity	13.0	1052.0	76.0	-0.72	0.022	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	389.0	28.0	-0.16	0.018	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	13.0	1702.0	125.0	-0.456	0.032	1000.0	-1000.0	-0.099	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	419.0	31.0	-0.155	0.014	1000.0	-1000.0	-0.082	-1000.0
Nongenotropic Androgen signaling	13.0	685.0	52.0	-0.087	0.022	1000.0	-1000.0	-0.061	-1000.0
Wnt signaling	13.0	97.0	7.0	-0.032	0.013	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	12.0	686.0	56.0	-0.18	0.019	1000.0	-1000.0	-0.071	-1000.0
IL27-mediated signaling events	12.0	624.0	51.0	-1.062	0.176	1000.0	-1000.0	-0.084	-1000.0
IL6-mediated signaling events	12.0	945.0	75.0	-0.274	0.053	1000.0	-1000.0	-0.091	-1000.0
IL12-mediated signaling events	11.0	961.0	87.0	-0.176	0.025	1000.0	-1000.0	-0.136	-1000.0
ErbB4 signaling events	11.0	786.0	69.0	-0.301	0.118	1000.0	-1000.0	-0.087	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	618.0	54.0	-0.236	0.025	1000.0	-1000.0	-0.083	-1000.0
HIF-1-alpha transcription factor network	11.0	844.0	76.0	-0.155	0.05	1000.0	-1000.0	-0.152	-1000.0
E-cadherin signaling in keratinocytes	11.0	479.0	43.0	-0.304	0.036	1000.0	-1000.0	-0.063	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1455.0	136.0	-0.622	0.069	1000.0	-1000.0	-0.069	-1000.0
Osteopontin-mediated events	10.0	394.0	38.0	-0.111	0.037	1000.0	-1000.0	-0.093	-1000.0
Noncanonical Wnt signaling pathway	10.0	278.0	26.0	-0.163	0.013	1000.0	-1000.0	-0.056	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	627.0	61.0	-0.221	0.104	1000.0	-1000.0	-0.076	-1000.0
S1P3 pathway	10.0	455.0	42.0	-0.16	0.02	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Rods	10.0	564.0	52.0	-0.209	0.013	1000.0	-1000.0	-0.082	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.009	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Regulation of Androgen receptor activity	10.0	729.0	70.0	-0.831	0.028	1000.0	-1000.0	-0.064	-1000.0
EPHB forward signaling	9.0	784.0	85.0	-0.216	0.071	1000.0	-1000.0	-0.099	-1000.0
Regulation of Telomerase	9.0	1019.0	102.0	-0.726	0.043	1000.0	-1000.0	-0.104	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	307.0	33.0	-0.227	0.036	1000.0	-1000.0	-0.054	-1000.0
PLK2 and PLK4 events	8.0	24.0	3.0	-0.011	0.01	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	8.0	151.0	17.0	-0.061	0.031	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	463.0	52.0	-0.332	0.057	1000.0	-1000.0	-0.056	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	659.0	76.0	-0.055	0.03	1000.0	-1000.0	-0.076	-1000.0
Syndecan-2-mediated signaling events	7.0	535.0	69.0	-0.47	0.04	1000.0	-1000.0	-0.047	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	692.0	97.0	-0.129	0.03	1000.0	-1000.0	-0.08	-1000.0
Insulin-mediated glucose transport	7.0	249.0	32.0	-0.139	0.07	1000.0	-1000.0	-0.073	-1000.0
Ceramide signaling pathway	7.0	597.0	76.0	-0.725	0.249	1000.0	-1000.0	-0.058	-1000.0
IL23-mediated signaling events	7.0	463.0	60.0	-0.115	0.023	1000.0	-1000.0	-0.158	-1000.0
PDGFR-beta signaling pathway	7.0	729.0	97.0	-0.139	0.046	1000.0	-1000.0	-0.08	-1000.0
Caspase cascade in apoptosis	6.0	514.0	74.0	-0.414	0.041	1000.0	-1000.0	-0.037	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	110.0	17.0	-0.032	0.029	1000.0	-1000.0	-0.056	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	555.0	85.0	-0.112	0.035	1000.0	-1000.0	-0.071	-1000.0
IL1-mediated signaling events	6.0	423.0	62.0	-0.203	0.059	1000.0	-1000.0	-0.102	-1000.0
Syndecan-3-mediated signaling events	6.0	222.0	35.0	-0.18	0.019	1000.0	-1000.0	-0.063	-1000.0
TCGA08_rtk_signaling	6.0	178.0	26.0	-0.296	0.028	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by STAT5	6.0	149.0	22.0	-0.048	0.046	1000.0	-1000.0	-0.045	-1000.0
BCR signaling pathway	6.0	651.0	99.0	-0.08	0.032	1000.0	-1000.0	-0.084	-1000.0
BARD1 signaling events	5.0	306.0	57.0	-0.117	0.027	1000.0	-1000.0	-0.072	-1000.0
Nectin adhesion pathway	5.0	330.0	63.0	-0.085	0.047	1000.0	-1000.0	-0.067	-1000.0
IL2 signaling events mediated by PI3K	5.0	306.0	58.0	-0.055	0.057	1000.0	-1000.0	-0.079	-1000.0
Canonical Wnt signaling pathway	5.0	256.0	51.0	-0.22	0.11	1000.0	-1000.0	-0.057	-1000.0
Regulation of p38-alpha and p38-beta	5.0	279.0	54.0	-0.194	0.062	1000.0	-1000.0	-0.06	-1000.0
S1P4 pathway	5.0	149.0	25.0	-0.061	0.027	1000.0	-1000.0	-0.052	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	101.0	17.0	-0.007	0.026	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	4.0	332.0	68.0	-0.32	0.068	1000.0	-1000.0	-0.09	-1000.0
Ephrin B reverse signaling	4.0	223.0	48.0	-0.084	0.023	1000.0	-1000.0	-0.074	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	381.0	83.0	-0.272	0.049	1000.0	-1000.0	-0.069	-1000.0
LPA receptor mediated events	4.0	442.0	102.0	-0.115	0.054	1000.0	-1000.0	-0.087	-1000.0
ErbB2/ErbB3 signaling events	3.0	205.0	65.0	-0.12	0.034	1000.0	-1000.0	-0.069	-1000.0
Cellular roles of Anthrax toxin	3.0	151.0	39.0	-0.201	0.018	1000.0	-1000.0	-0.028	-1000.0
FAS signaling pathway (CD95)	3.0	164.0	47.0	-0.11	0.022	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	3.0	259.0	71.0	-0.343	0.041	1000.0	-1000.0	-0.076	-1000.0
IGF1 pathway	3.0	198.0	57.0	-0.039	0.043	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by PRL	3.0	106.0	34.0	-0.03	0.022	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class II	2.0	170.0	75.0	-0.157	0.038	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	2.0	145.0	60.0	-0.095	0.04	1000.0	-1000.0	-0.052	-1000.0
PLK1 signaling events	2.0	240.0	85.0	-0.091	0.024	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	141.0	68.0	-0.139	0.047	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	2.0	104.0	43.0	-0.222	0.126	1000.0	-1000.0	-0.088	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	34.0	15.0	0.0	0.025	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	2.0	156.0	58.0	-0.061	0.034	1000.0	-1000.0	-0.07	-1000.0
Class I PI3K signaling events	2.0	216.0	73.0	-0.063	0.038	1000.0	-1000.0	-0.064	-1000.0
Insulin Pathway	2.0	159.0	74.0	-0.044	0.034	1000.0	-1000.0	-0.087	-1000.0
Visual signal transduction: Cones	1.0	72.0	38.0	-0.015	0.016	1000.0	-1000.0	-0.067	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	97.0	65.0	-0.061	0.062	1000.0	-1000.0	-0.063	-1000.0
EPO signaling pathway	1.0	59.0	55.0	-0.035	0.075	1000.0	-1000.0	-0.085	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	47.0	37.0	-0.03	0.032	1000.0	-1000.0	-0.059	-1000.0
TRAIL signaling pathway	1.0	54.0	48.0	-0.008	0.044	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by HDAC Class I	1.0	160.0	104.0	-0.157	0.053	1000.0	-1000.0	-0.067	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	66.0	45.0	-0.027	0.059	1000.0	-1000.0	-0.083	-1000.0
VEGFR1 specific signals	1.0	91.0	56.0	-0.007	0.048	1000.0	-1000.0	-0.076	-1000.0
Rapid glucocorticoid signaling	1.0	21.0	20.0	-0.002	0.013	1000.0	-1000.0	-0.043	-1000.0
p38 MAPK signaling pathway	1.0	62.0	44.0	-0.042	0.041	1000.0	-1000.0	-0.064	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	-0.002	0.045	1000.0	-1000.0	-0.059	-1000.0
Canonical NF-kappaB pathway	0.0	38.0	39.0	-0.011	0.078	1000.0	-1000.0	-0.087	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.012	0.044	1000.0	-1000.0	-0.05	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	1.0	5.0	0.011	0.018	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	0.0	3.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	0.0	51.0	53.0	-0.006	0.033	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class III	0.0	27.0	40.0	-0.02	0.022	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	0.0	45.0	49.0	-0.011	0.046	1000.0	-1000.0	-0.054	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.153	0.096	1000.0	-1000.0	-0.016	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	3.0	36.0	-0.036	0.038	1000.0	-1000.0	-0.074	-1000.0
Atypical NF-kappaB pathway	0.0	30.0	31.0	-0.003	0.046	1000.0	-1000.0	-0.044	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.032	1000.0	-1000.0	-0.056	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.006	0.03	1000.0	-1000.0	-0.043	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.019	1000.0	-1000.0	-0.065	-1000.0
Total	1865	108455	7203	-31.951607108	-1993.61480355	131000	-131000	-8.7218922829	-131000