Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.002 0.109 -9999.0 0.0 -0.381 3.0 3.0 IHH -0.032 0.208 -9999.0 0.0 -0.664 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.002 0.086 -9999.0 0.0 -0.317 18.0 18.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.085 0.315 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.007 0.133 -9999.0 0.0 -0.41 21.0 21.0 SMO -0.015 0.13 -9999.0 0.0 -0.427 22.0 22.0 AKT1 -0.011 0.131 -9999.0 0.0 -0.585 8.0 8.0 ARRB2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.016 0.128 -9999.0 0.0 -0.421 22.0 22.0 STIL 0.021 0.121 0.256 1.0 -0.301 21.0 22.0 DHH N/PTCH2 0.004 0.125 -9999.0 0.0 -0.478 18.0 18.0 DHH N/PTCH1 -0.019 0.15 -9999.0 0.0 -0.36 45.0 45.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.018 0.161 -9999.0 0.0 -0.639 18.0 18.0 PTHLH -0.014 0.136 -9999.0 0.0 -0.485 3.0 3.0 determination of left/right symmetry -0.016 0.128 -9999.0 0.0 -0.421 22.0 22.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.013 0.135 -9999.0 0.0 -0.482 3.0 3.0 IHH N/Hhip -0.026 0.17 -9999.0 0.0 -0.45 39.0 39.0 DHH N/Hhip -0.015 0.165 -9999.0 0.0 -0.523 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.016 0.128 -9999.0 0.0 -0.421 22.0 22.0 pancreas development -0.004 0.128 -9999.0 0.0 -0.638 11.0 11.0 HHAT 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.146 -9999.0 0.0 -0.6 16.0 16.0 somite specification -0.016 0.128 -9999.0 0.0 -0.421 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.006 0.097 -9999.0 0.0 -0.306 25.0 25.0 SHH Np/Cholesterol/PTCH2 0.014 0.043 -9999.0 0.0 -0.375 3.0 3.0 SHH Np/Cholesterol/Megalin -0.021 0.125 -9999.0 0.0 -0.393 28.0 28.0 SHH 0.005 0.051 -9999.0 0.0 -0.481 3.0 3.0 catabolic process -0.007 0.123 -9999.0 0.0 -0.379 28.0 28.0 SMO/Vitamin D3 -0.009 0.114 -9999.0 0.0 -0.374 22.0 22.0 SHH Np/Cholesterol/Hhip -0.0 0.083 -9999.0 0.0 -0.355 14.0 14.0 LRP2 -0.034 0.192 -9999.0 0.0 -0.627 27.0 27.0 receptor-mediated endocytosis -0.036 0.157 -9999.0 0.0 -0.535 16.0 16.0 SHH Np/Cholesterol/BOC 0.016 0.043 -9999.0 0.0 -0.38 3.0 3.0 SHH Np/Cholesterol/CDO 0.015 0.044 -9999.0 0.0 -0.38 3.0 3.0 mesenchymal cell differentiation 0.0 0.082 0.353 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.029 0.127 -9999.0 0.0 -0.309 25.0 25.0 IHH N/PTCH2 -0.005 0.138 -9999.0 0.0 -0.42 28.0 28.0 CDON 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.001 0.127 -9999.0 0.0 -0.383 28.0 28.0 Megalin/LRPAP1 -0.007 0.149 -9999.0 0.0 -0.468 27.0 27.0 PTCH2 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.008 0.041 -9999.0 0.0 -0.379 3.0 3.0 PTCH1 -0.007 0.124 -9999.0 0.0 -0.38 28.0 28.0 HHIP -0.004 0.128 -9999.0 0.0 -0.639 11.0 11.0