Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.001 0.081 -9999.0 0.0 -0.278 22.0 22.0 epithelial cell differentiation 0.021 0.111 -9999.0 0.0 -0.358 22.0 22.0 CYFIP2 0.025 0.039 -9999.0 0.0 -0.639 1.0 1.0 ENAH 0.0 0.133 0.525 11.0 -9999.0 0.0 11.0 EGFR 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.001 0.118 0.344 8.0 -0.346 22.0 30.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.031 -9999.0 0.0 -0.416 1.0 1.0 AQP5 -0.07 0.189 -9999.0 0.0 -0.559 31.0 31.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.003 0.118 0.342 9.0 -0.341 22.0 31.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.149 0.346 6.0 -0.376 36.0 42.0 EGF -0.56 0.206 -9999.0 0.0 -0.628 258.0 258.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.173 0.269 -9999.0 0.0 -0.557 88.0 88.0 cortical microtubule organization 0.021 0.111 -9999.0 0.0 -0.358 22.0 22.0 GO:0000145 -0.015 0.112 0.331 9.0 -0.326 22.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.114 -9999.0 0.0 -0.362 22.0 22.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.035 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.096 0.345 2.0 -0.32 20.0 22.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.104 0.348 3.0 -0.346 20.0 23.0 ARF6/GTP 0.064 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.025 0.177 -9999.0 0.0 -0.639 22.0 22.0 EGFR/EGFR/EGF/EGF -0.273 0.158 -9999.0 0.0 -0.369 185.0 185.0 RhoA/GDP 0.024 0.107 -9999.0 0.0 -0.343 22.0 22.0 actin cytoskeleton organization -0.016 0.112 0.328 8.0 -0.336 22.0 30.0 IGF-1R heterotetramer 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.013 0.095 -9999.0 0.0 -0.639 6.0 6.0 DIAPH1 0.035 0.106 -9999.0 0.0 -0.538 4.0 4.0 Wnt receptor signaling pathway -0.021 0.111 0.358 22.0 -9999.0 0.0 22.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.078 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.114 0.331 8.0 -0.343 22.0 30.0 EFNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.101 0.342 3.0 -0.33 22.0 25.0 Ephrin A1/EPHA2 0.016 0.103 -9999.0 0.0 -0.334 22.0 22.0 SEC6/SEC8 -0.013 0.086 -9999.0 0.0 -0.324 20.0 20.0 MGAT3 -0.025 0.152 0.348 6.0 -0.383 36.0 42.0 HGF/MET -0.002 0.121 -9999.0 0.0 -0.363 26.0 26.0 HGF -0.004 0.127 -9999.0 0.0 -0.639 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.001 0.081 -9999.0 0.0 -0.28 22.0 22.0 actin cable formation 0.03 0.15 0.565 14.0 -0.289 1.0 15.0 KIAA1543 -0.016 0.115 0.333 9.0 -0.33 23.0 32.0 KIFC3 -0.015 0.096 -9999.0 0.0 -0.346 22.0 22.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.003 0.12 0.344 9.0 -0.343 22.0 31.0 NCK1/GIT1 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.111 -9999.0 0.0 -0.358 22.0 22.0 EXOC4 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.097 -9999.0 0.0 -0.346 22.0 22.0 PIP5K1C 0.003 0.12 0.344 9.0 -0.346 22.0 31.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.002 0.146 0.542 12.0 -9999.0 0.0 12.0 adherens junction assembly 0.006 0.129 0.395 13.0 -0.353 1.0 14.0 IGF-1R heterotetramer/IGF1 0.01 0.114 -9999.0 0.0 -0.337 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.002 0.122 0.344 9.0 -0.345 23.0 32.0 mol:GTP 0.057 0.027 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.003 0.114 0.317 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.001 0.081 -9999.0 0.0 -0.278 22.0 22.0 regulation of cell-cell adhesion -0.016 0.112 0.328 8.0 -0.336 22.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.001 0.081 -9999.0 0.0 -0.28 22.0 22.0