Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	129.0	4392.0	34.0	-0.453	0.028	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	98.0	8667.0	88.0	-0.897	0.094	1000.0	-1000.0	-0.074	-1000.0
EGFR-dependent Endothelin signaling events	89.0	1872.0	21.0	-0.56	0.038	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	76.0	3532.0	46.0	-1.08	0.031	1000.0	-1000.0	-0.109	-1000.0
PDGFR-alpha signaling pathway	63.0	2808.0	44.0	-0.252	0.038	1000.0	-1000.0	-0.048	-1000.0
Thromboxane A2 receptor signaling	50.0	5336.0	105.0	-0.56	0.097	1000.0	-1000.0	-0.048	-1000.0
Signaling mediated by p38-alpha and p38-beta	41.0	1818.0	44.0	-0.172	0.027	1000.0	-1000.0	-0.034	-1000.0
Glypican 1 network	38.0	1844.0	48.0	-0.326	0.051	1000.0	-1000.0	-0.033	-1000.0
BMP receptor signaling	33.0	2682.0	81.0	-0.371	0.055	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	33.0	2606.0	78.0	-0.27	0.063	1000.0	-1000.0	-0.062	-1000.0
Endothelins	31.0	3036.0	96.0	-0.609	0.034	1000.0	-1000.0	-0.054	-1000.0
Arf6 signaling events	29.0	1805.0	62.0	-0.56	0.059	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	29.0	3706.0	125.0	-0.136	0.062	1000.0	-1000.0	-0.066	-1000.0
IL4-mediated signaling events	27.0	2471.0	91.0	-0.867	0.522	1000.0	-1000.0	-0.102	-1000.0
Integrins in angiogenesis	24.0	2095.0	84.0	-0.407	0.058	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by PTP1B	23.0	1773.0	76.0	-0.563	0.084	1000.0	-1000.0	-0.035	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	23.0	1598.0	68.0	-0.481	0.087	1000.0	-1000.0	-0.078	-1000.0
amb2 Integrin signaling	22.0	1816.0	82.0	-0.369	0.036	1000.0	-1000.0	-0.036	-1000.0
Ceramide signaling pathway	22.0	1736.0	76.0	-0.56	0.197	1000.0	-1000.0	-0.047	-1000.0
S1P1 pathway	21.0	765.0	36.0	-0.163	0.027	1000.0	-1000.0	-0.045	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2556.0	120.0	-0.23	0.115	1000.0	-1000.0	-0.052	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	20.0	1483.0	74.0	-0.56	0.064	1000.0	-1000.0	-0.073	-1000.0
FoxO family signaling	16.0	1065.0	64.0	-0.858	0.063	1000.0	-1000.0	-0.065	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1431.0	86.0	-0.135	0.048	1000.0	-1000.0	-0.053	-1000.0
Ephrin A  reverse signaling	15.0	105.0	7.0	-0.032	0.0	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by the Hedgehog family	14.0	743.0	52.0	-0.036	0.04	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	14.0	1684.0	114.0	-0.575	0.145	1000.0	-1000.0	-0.06	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1197.0	82.0	-0.064	0.028	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1211.0	93.0	-0.196	0.107	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling events	13.0	65.0	5.0	-0.025	0.027	1000.0	-1000.0	0.001	-1000.0
LPA4-mediated signaling events	12.0	148.0	12.0	-0.14	0.007	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	12.0	981.0	76.0	-0.643	0.05	1000.0	-1000.0	-0.033	-1000.0
Syndecan-3-mediated signaling events	12.0	450.0	35.0	-0.096	0.075	1000.0	-1000.0	-0.025	-1000.0
Nongenotropic Androgen signaling	12.0	667.0	52.0	-0.107	0.045	1000.0	-1000.0	-0.042	-1000.0
TCGA08_rtk_signaling	11.0	291.0	26.0	-0.22	0.062	1000.0	-1000.0	-0.009	-1000.0
S1P3 pathway	11.0	483.0	42.0	-0.109	0.039	1000.0	-1000.0	-0.036	-1000.0
Caspase cascade in apoptosis	10.0	792.0	74.0	-0.415	0.066	1000.0	-1000.0	-0.041	-1000.0
p75(NTR)-mediated signaling	10.0	1346.0	125.0	-0.359	0.075	1000.0	-1000.0	-0.079	-1000.0
EPHB forward signaling	10.0	859.0	85.0	-0.151	0.075	1000.0	-1000.0	-0.075	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	314.0	31.0	-0.106	0.028	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in keratinocytes	10.0	447.0	43.0	-0.219	0.043	1000.0	-1000.0	-0.041	-1000.0
ErbB4 signaling events	9.0	637.0	69.0	-0.225	0.087	1000.0	-1000.0	-0.046	-1000.0
Osteopontin-mediated events	9.0	353.0	38.0	-0.065	0.048	1000.0	-1000.0	-0.048	-1000.0
Reelin signaling pathway	9.0	517.0	56.0	-0.12	0.071	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	9.0	490.0	51.0	-1.005	0.249	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	9.0	739.0	75.0	-0.222	0.041	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	728.0	76.0	-0.032	0.048	1000.0	-1000.0	-0.058	-1000.0
IL23-mediated signaling events	9.0	570.0	60.0	-0.061	0.04	1000.0	-1000.0	-0.094	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1192.0	136.0	-0.479	0.095	1000.0	-1000.0	-0.049	-1000.0
Syndecan-1-mediated signaling events	8.0	275.0	34.0	-0.037	0.028	1000.0	-1000.0	-0.049	-1000.0
Noncanonical Wnt signaling pathway	8.0	215.0	26.0	-0.137	0.027	1000.0	-1000.0	-0.055	-1000.0
HIF-1-alpha transcription factor network	8.0	637.0	76.0	-0.104	0.086	1000.0	-1000.0	-0.089	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	746.0	85.0	-0.1	0.109	1000.0	-1000.0	-0.049	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	531.0	61.0	-0.154	0.083	1000.0	-1000.0	-0.053	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	453.0	52.0	-0.239	0.084	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	8.0	232.0	26.0	-0.168	0.045	1000.0	-1000.0	-0.02	-1000.0
Regulation of Telomerase	8.0	870.0	102.0	-0.56	0.068	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Rods	8.0	447.0	52.0	-0.15	0.053	1000.0	-1000.0	-0.046	-1000.0
Regulation of Androgen receptor activity	8.0	594.0	70.0	-0.754	0.044	1000.0	-1000.0	-0.055	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	200.0	28.0	-0.109	0.044	1000.0	-1000.0	-0.025	-1000.0
ceramide signaling pathway	7.0	375.0	49.0	0.0	0.041	1000.0	-1000.0	-0.049	-1000.0
Regulation of p38-alpha and p38-beta	7.0	402.0	54.0	-0.139	0.065	1000.0	-1000.0	-0.053	-1000.0
Syndecan-4-mediated signaling events	7.0	484.0	67.0	-0.348	0.092	1000.0	-1000.0	-0.046	-1000.0
PDGFR-beta signaling pathway	7.0	772.0	97.0	-0.032	0.059	1000.0	-1000.0	-0.061	-1000.0
Cellular roles of Anthrax toxin	6.0	243.0	39.0	-0.146	0.036	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	6.0	425.0	68.0	-0.249	0.066	1000.0	-1000.0	-0.06	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.008	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	318.0	54.0	-0.059	0.047	1000.0	-1000.0	-0.048	-1000.0
Syndecan-2-mediated signaling events	5.0	363.0	69.0	-0.369	0.054	1000.0	-1000.0	-0.046	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	565.0	97.0	-0.065	0.049	1000.0	-1000.0	-0.063	-1000.0
PLK1 signaling events	5.0	431.0	85.0	-0.008	0.054	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	5.0	336.0	62.0	-0.143	0.072	1000.0	-1000.0	-0.048	-1000.0
S1P5 pathway	5.0	86.0	17.0	-0.012	0.027	1000.0	-1000.0	-0.015	-1000.0
Ephrin B reverse signaling	5.0	279.0	48.0	-0.019	0.039	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	5.0	39.0	7.0	-0.035	0.028	1000.0	-1000.0	-0.011	-1000.0
Canonical Wnt signaling pathway	5.0	272.0	51.0	-0.153	0.078	1000.0	-1000.0	-0.057	-1000.0
Wnt signaling	5.0	41.0	7.0	-0.003	0.027	1000.0	-1000.0	-0.025	-1000.0
Arf6 trafficking events	5.0	377.0	71.0	-0.248	0.047	1000.0	-1000.0	-0.036	-1000.0
BCR signaling pathway	5.0	574.0	99.0	-0.043	0.062	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	101.0	17.0	-0.006	0.042	1000.0	-1000.0	-0.036	-1000.0
ErbB2/ErbB3 signaling events	4.0	281.0	65.0	-0.059	0.048	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	4.0	368.0	87.0	-0.164	0.06	1000.0	-1000.0	-0.086	-1000.0
Nectin adhesion pathway	4.0	267.0	63.0	-0.025	0.054	1000.0	-1000.0	-0.054	-1000.0
LPA receptor mediated events	4.0	448.0	102.0	-0.07	0.062	1000.0	-1000.0	-0.074	-1000.0
IGF1 pathway	4.0	232.0	57.0	-0.022	0.065	1000.0	-1000.0	-0.045	-1000.0
S1P4 pathway	4.0	118.0	25.0	-0.012	0.053	1000.0	-1000.0	-0.029	-1000.0
mTOR signaling pathway	3.0	199.0	53.0	-0.017	0.048	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	229.0	68.0	-0.03	0.055	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	271.0	83.0	-0.233	0.048	1000.0	-1000.0	-0.041	-1000.0
FAS signaling pathway (CD95)	3.0	153.0	47.0	-0.119	0.04	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	3.0	232.0	73.0	-0.021	0.048	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PRL	3.0	111.0	34.0	-0.037	0.04	1000.0	-1000.0	-0.05	-1000.0
FOXM1 transcription factor network	3.0	159.0	51.0	-0.093	0.046	1000.0	-1000.0	-0.099	-1000.0
Aurora B signaling	3.0	245.0	67.0	-0.244	0.049	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class II	2.0	158.0	75.0	-0.105	0.071	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	2.0	167.0	57.0	-0.049	0.06	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	175.0	65.0	-0.012	0.066	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	2.0	162.0	55.0	-0.003	0.075	1000.0	-1000.0	-0.048	-1000.0
Insulin-mediated glucose transport	2.0	68.0	32.0	-0.03	0.049	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	2.0	128.0	43.0	-0.176	0.096	1000.0	-1000.0	-0.057	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	43.0	15.0	-0.01	0.028	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by PI3K	2.0	149.0	58.0	-0.015	0.062	1000.0	-1000.0	-0.047	-1000.0
Insulin Pathway	2.0	211.0	74.0	-0.024	0.071	1000.0	-1000.0	-0.047	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	87.0	33.0	-0.054	0.068	1000.0	-1000.0	-0.031	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	25.0	23.0	-0.01	0.048	1000.0	-1000.0	-0.035	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	24.0	17.0	0.014	0.045	1000.0	-1000.0	-0.038	-1000.0
Arf6 downstream pathway	1.0	67.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class I	1.0	166.0	104.0	-0.105	0.067	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	1.0	110.0	58.0	-0.033	0.058	1000.0	-1000.0	-0.052	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	69.0	45.0	0.0	0.077	1000.0	-1000.0	-0.058	-1000.0
TCGA08_retinoblastoma	1.0	10.0	8.0	-0.053	0.032	1000.0	-1000.0	-0.003	-1000.0
VEGFR1 specific signals	1.0	89.0	56.0	-0.012	0.064	1000.0	-1000.0	-0.063	-1000.0
Canonical NF-kappaB pathway	0.0	19.0	39.0	-0.0	0.061	1000.0	-1000.0	-0.04	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.009	0.026	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Cones	0.0	29.0	38.0	-0.018	0.055	1000.0	-1000.0	-0.019	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.009	0.059	1000.0	-1000.0	-0.047	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.027	0.04	1000.0	-1000.0	0.003	-1000.0
Aurora A signaling	0.0	19.0	60.0	-0.009	0.062	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.02	0.028	1000.0	-1000.0	-0.014	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	5.0	37.0	-0.01	0.063	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class III	0.0	16.0	40.0	-0.049	0.05	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	0.0	5.0	48.0	-0.0	0.07	1000.0	-1000.0	-0.051	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	1.0	36.0	-0.054	0.057	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	0.0	22.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.031	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.005	-0.001	1000.0	-1000.0	0.0	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	0.007	0.041	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.004	0.034	1000.0	-1000.0	-0.006	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.0	0.055	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	0.0	25.0	54.0	-0.001	0.048	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.075	1000.0	-1000.0	-0.0	-1000.0
Total	1522	97030	7203	-23.7474675605	7.96011556047	131000	-131000	-5.84012277469	-131000