E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.143 0.224 -9999.0 0.0 -0.422 10.0 10.0 KLHL20 -0.028 0.108 0.225 1.0 -0.204 2.0 3.0 CYFIP2 0.027 0.033 -9999.0 0.0 -0.137 1.0 1.0 Rac1/GDP -0.074 0.145 -9999.0 0.0 -0.267 9.0 9.0 ENAH -0.143 0.221 -9999.0 0.0 -0.422 10.0 10.0 AP1M1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.001 0.116 -9999.0 0.0 -0.41 2.0 2.0 CDC42/GTP -0.047 0.114 -9999.0 0.0 -0.288 2.0 2.0 ABI1/Sra1/Nap1 -0.037 0.043 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.05 0.154 -9999.0 0.0 -0.246 9.0 9.0 RAPGEF1 -0.123 0.207 -9999.0 0.0 -0.398 9.0 9.0 CTNND1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.15 0.238 -9999.0 0.0 -0.449 10.0 10.0 CRK -0.132 0.223 -9999.0 0.0 -0.413 10.0 10.0 E-cadherin/gamma catenin/alpha catenin -0.053 0.135 -9999.0 0.0 -0.243 8.0 8.0 alphaE/beta7 Integrin 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.059 -9999.0 0.0 -0.219 1.0 1.0 DLG1 -0.142 0.219 -9999.0 0.0 -0.422 10.0 10.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.045 0.066 -9999.0 0.0 -0.2 1.0 1.0 MLLT4 0.016 0.084 -9999.0 0.0 -0.41 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.055 0.055 -9999.0 0.0 -0.219 1.0 1.0 PI3K -0.055 0.086 -9999.0 0.0 -0.258 1.0 1.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.08 0.146 -9999.0 0.0 -0.289 8.0 8.0 TIAM1 0.019 0.084 -9999.0 0.0 -0.41 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.049 0.141 -9999.0 0.0 -0.228 9.0 9.0 AKT1 -0.027 0.059 -9999.0 0.0 -0.15 1.0 1.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.19 -9999.0 0.0 -0.293 14.0 14.0 RhoA/GDP -0.067 0.163 -9999.0 0.0 -0.281 9.0 9.0 actin cytoskeleton organization -0.019 0.084 0.188 1.0 -0.15 2.0 3.0 CDC42/GDP -0.071 0.147 -9999.0 0.0 -0.264 9.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.059 0.106 -9999.0 0.0 -0.206 9.0 9.0 ITGB7 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.052 0.15 -9999.0 0.0 -0.243 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.057 0.134 -9999.0 0.0 -0.23 9.0 9.0 mol:GDP -0.092 0.163 -9999.0 0.0 -0.308 9.0 9.0 CDC42/GTP/IQGAP1 0.039 0.018 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.069 0.166 -9999.0 0.0 -0.284 9.0 9.0 RAC1/GTP/IQGAP1 0.042 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.084 -9999.0 0.0 -0.41 1.0 1.0 CDC42 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.011 0.065 0.143 1.0 -0.14 2.0 3.0 NME1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.148 0.228 -9999.0 0.0 -0.436 10.0 10.0 regulation of cell-cell adhesion -0.053 0.092 -9999.0 0.0 -0.253 2.0 2.0 WASF2 -0.004 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.058 0.126 -9999.0 0.0 -0.324 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.001 0.137 -9999.0 0.0 -0.207 8.0 8.0 CCND1 -0.014 0.077 0.163 1.0 -0.172 2.0 3.0 VAV2 -0.111 0.224 -9999.0 0.0 -0.53 2.0 2.0 RAP1/GDP -0.056 0.135 -9999.0 0.0 -0.254 5.0 5.0 adherens junction assembly -0.143 0.221 -9999.0 0.0 -0.422 10.0 10.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.044 0.139 -9999.0 0.0 -0.221 9.0 9.0 E-cadherin/beta catenin -0.075 0.142 -9999.0 0.0 -0.312 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.148 0.229 -9999.0 0.0 -0.437 10.0 10.0 PIK3CA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.091 0.11 -9999.0 0.0 -0.323 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.068 0.156 -9999.0 0.0 -0.271 9.0 9.0 ITGAE 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.153 0.243 -9999.0 0.0 -0.459 10.0 10.0