Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.074 0.143 -9999.0 0.0 -0.252 9.0 9.0 epithelial cell differentiation -0.052 0.137 -9999.0 0.0 -0.227 9.0 9.0 CYFIP2 0.027 0.033 -9999.0 0.0 -0.137 1.0 1.0 ENAH -0.059 0.086 -9999.0 0.0 -0.389 1.0 1.0 EGFR -0.007 0.119 -9999.0 0.0 -0.319 3.0 3.0 EPHA2 0.024 0.034 -9999.0 0.0 -0.137 1.0 1.0 MYO6 -0.073 0.141 0.185 1.0 -0.238 9.0 10.0 CTNNB1 0.001 0.116 -9999.0 0.0 -0.41 2.0 2.0 ABI1/Sra1/Nap1 0.055 0.036 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.111 -9999.0 0.0 -0.371 1.0 1.0 CTNND1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.057 0.107 0.184 1.0 -0.197 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.065 0.118 0.184 1.0 -0.213 9.0 10.0 EGF 0.02 0.045 -9999.0 0.0 -0.137 2.0 2.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.056 0.133 -9999.0 0.0 -0.404 2.0 2.0 cortical microtubule organization -0.052 0.137 -9999.0 0.0 -0.227 9.0 9.0 GO:0000145 -0.066 0.094 0.169 1.0 -0.188 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.049 0.141 -9999.0 0.0 -0.229 9.0 9.0 MLLT4 0.016 0.084 -9999.0 0.0 -0.41 1.0 1.0 ARF6/GDP -0.073 0.097 -9999.0 0.0 -0.212 6.0 6.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.05 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.063 0.101 -9999.0 0.0 -0.285 2.0 2.0 PVRL2 0.012 0.084 -9999.0 0.0 -0.41 1.0 1.0 ZYX -0.06 0.123 0.185 1.0 -0.218 9.0 10.0 ARF6/GTP 0.079 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.19 -9999.0 0.0 -0.293 14.0 14.0 EGFR/EGFR/EGF/EGF -0.075 0.128 -9999.0 0.0 -0.216 11.0 11.0 RhoA/GDP -0.052 0.152 -9999.0 0.0 -0.234 9.0 9.0 actin cytoskeleton organization -0.074 0.135 0.173 1.0 -0.232 9.0 10.0 IGF-1R heterotetramer 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.019 0.084 -9999.0 0.0 -0.41 1.0 1.0 DIAPH1 0.023 0.152 -9999.0 0.0 -0.536 1.0 1.0 Wnt receptor signaling pathway 0.052 0.137 0.227 9.0 -9999.0 0.0 9.0 RHOA 0.016 0.084 -9999.0 0.0 -0.41 1.0 1.0 RhoA/GTP -0.078 0.118 -9999.0 0.0 -0.25 5.0 5.0 CTNNA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.076 0.138 0.175 1.0 -0.237 9.0 10.0 EFNA1 0.029 0.032 -9999.0 0.0 -0.137 1.0 1.0 LPP -0.062 0.1 0.177 1.0 -0.2 2.0 3.0 Ephrin A1/EPHA2 -0.057 0.127 -9999.0 0.0 -0.213 9.0 9.0 SEC6/SEC8 -0.075 0.127 -9999.0 0.0 -0.226 9.0 9.0 MGAT3 -0.066 0.119 0.185 1.0 -0.216 9.0 10.0 HGF/MET -0.056 0.127 -9999.0 0.0 -0.218 9.0 9.0 HGF 0.012 0.054 -9999.0 0.0 -0.137 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.074 0.145 -9999.0 0.0 -0.254 9.0 9.0 actin cable formation -0.035 0.081 -9999.0 0.0 -0.26 1.0 1.0 KIAA1543 -0.08 0.096 -9999.0 0.0 -0.206 9.0 9.0 KIFC3 -0.066 0.121 0.185 1.0 -0.218 9.0 10.0 NCK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.069 0.12 0.185 1.0 -0.218 9.0 10.0 NCK1/GIT1 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.052 0.137 -9999.0 0.0 -0.227 9.0 9.0 EXOC4 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.066 0.121 0.185 1.0 -0.218 9.0 10.0 PIP5K1C -0.058 0.109 0.185 1.0 -0.199 9.0 10.0 LIMA1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.068 0.106 -9999.0 0.0 -0.466 1.0 1.0 adherens junction assembly -0.042 0.114 0.293 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.056 0.147 -9999.0 0.0 -0.232 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.088 -9999.0 0.0 -0.289 2.0 2.0 MET 0.025 0.034 -9999.0 0.0 -0.137 1.0 1.0 PLEKHA7 -0.072 0.11 -9999.0 0.0 -0.216 9.0 9.0 mol:GTP 0.06 0.049 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.044 0.155 0.285 1.0 -0.36 2.0 3.0 cortical actin cytoskeleton stabilization -0.074 0.143 -9999.0 0.0 -0.252 9.0 9.0 regulation of cell-cell adhesion -0.074 0.135 0.173 1.0 -0.232 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.074 0.145 -9999.0 0.0 -0.254 9.0 9.0