Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.192 -9999.0 0.0 -0.581 53.0 53.0 IHH 0.012 0.056 0.18 1.0 -0.192 8.0 9.0 SHH Np/Cholesterol/GAS1 -0.011 0.084 0.155 12.0 -0.237 53.0 65.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.083 0.235 53.0 -0.154 12.0 65.0 SMO/beta Arrestin2 -0.005 0.115 -9999.0 0.0 -0.394 20.0 20.0 SMO -0.02 0.111 -9999.0 0.0 -0.366 33.0 33.0 AKT1 -0.003 0.106 -9999.0 0.0 -0.531 13.0 13.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.036 -9999.0 0.0 -0.428 3.0 3.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.019 0.11 -9999.0 0.0 -0.361 33.0 33.0 STIL -0.012 0.133 0.231 3.0 -0.275 56.0 59.0 DHH N/PTCH2 0.004 0.085 -9999.0 0.0 -0.307 31.0 31.0 DHH N/PTCH1 -0.02 0.122 -9999.0 0.0 -0.281 79.0 79.0 PIK3CA 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 DHH -0.007 0.105 -9999.0 0.0 -0.428 27.0 27.0 PTHLH -0.061 0.255 -9999.0 0.0 -0.775 53.0 53.0 determination of left/right symmetry -0.019 0.11 -9999.0 0.0 -0.361 33.0 33.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.06 0.252 -9999.0 0.0 -0.766 53.0 53.0 IHH N/Hhip -0.04 0.136 -9999.0 0.0 -0.334 78.0 78.0 DHH N/Hhip -0.049 0.14 -9999.0 0.0 -0.312 101.0 101.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.019 0.11 -9999.0 0.0 -0.361 33.0 33.0 pancreas development -0.058 0.159 -9999.0 0.0 -0.292 135.0 135.0 HHAT 0.012 0.077 -9999.0 0.0 -0.428 15.0 15.0 PI3K 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.016 0.047 -9999.0 0.0 -0.428 3.0 3.0 somite specification -0.019 0.11 -9999.0 0.0 -0.361 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.036 0.113 -9999.0 0.0 -0.279 68.0 68.0 SHH Np/Cholesterol/PTCH2 -0.016 0.082 0.154 2.0 -0.238 56.0 58.0 SHH Np/Cholesterol/Megalin -0.059 0.124 0.154 8.0 -0.269 115.0 123.0 SHH -0.03 0.097 -9999.0 0.0 -0.308 52.0 52.0 catabolic process -0.018 0.117 -9999.0 0.0 -0.342 52.0 52.0 SMO/Vitamin D3 -0.032 0.117 0.288 2.0 -0.324 39.0 41.0 SHH Np/Cholesterol/Hhip -0.048 0.119 0.155 8.0 -0.27 98.0 106.0 LRP2 -0.093 0.181 -9999.0 0.0 -0.307 183.0 183.0 receptor-mediated endocytosis -0.066 0.143 -9999.0 0.0 -0.403 47.0 47.0 SHH Np/Cholesterol/BOC -0.014 0.08 -9999.0 0.0 -0.236 54.0 54.0 SHH Np/Cholesterol/CDO -0.02 0.089 0.172 1.0 -0.25 59.0 60.0 mesenchymal cell differentiation 0.048 0.118 0.269 98.0 -0.153 8.0 106.0 mol:Vitamin D3 -0.001 0.145 0.322 3.0 -0.28 68.0 71.0 IHH N/PTCH2 0.023 0.051 -9999.0 0.0 -0.332 6.0 6.0 CDON 0.001 0.095 -9999.0 0.0 -0.428 23.0 23.0 IHH N/PTCH1 -0.011 0.121 -9999.0 0.0 -0.344 52.0 52.0 Megalin/LRPAP1 -0.052 0.137 -9999.0 0.0 -0.303 108.0 108.0 PTCH2 0.016 0.048 -9999.0 0.0 -0.28 10.0 10.0 SHH Np/Cholesterol -0.019 0.075 0.202 1.0 -0.233 52.0 53.0 PTCH1 -0.019 0.118 -9999.0 0.0 -0.343 52.0 52.0 HHIP -0.058 0.159 -9999.0 0.0 -0.292 135.0 135.0