Hybridization REF p difference q subclass Composite Element REF p difference q subclass SERPINE1|PAI-1 9.59146284118892e-06 0.93400188264373 5.83480656172326e-05 1 FN1|FIBRONECTIN 2.48102223232397e-06 0.676180631831505 2.01238469955166e-05 1 GAPDH|GAPDH 2.13549712519722e-05 0.634300249456897 0.000106289516004134 1 BCL2A1|BCL2A1 6.29989315783419e-10 0.501622157110502 6.89838300782844e-08 1 SYK|SYK 2.12159048582245e-05 0.482389509851254 0.000106289516004134 1 SQSTM1|P62-LCK-LIGAND 0.0368506348918943 0.455385769684169 0.0589072192797434 1 TFRC|TFRC 3.35135740375197e-05 0.438709099797962 0.000141143706042631 1 TIGAR|TIGAR 2.71077754626699e-05 0.435188035285737 0.000129056583180972 1 YWHAZ|14-3-3_ZETA 3.8200306235741e-05 0.432388726264107 0.000154923464178283 1 ACACA|ACC1 0.00489144190403579 0.415829736668495 0.0101059035564513 1 CHEK1|CHK1_PS296 3.79231345910835e-10 0.384862004861285 6.89838300782844e-08 1 DIABLO|SMAC 3.21267190071888e-05 0.364148378713636 0.000140715029251487 1 PEA15|PEA15 8.86189168461035e-06 0.359703420700157 5.54501222551333e-05 1 BAX|BAX 7.01893340436344e-05 0.350710286497649 0.000265025244061309 1 CDKN2A|P16_INK4A 0.000698702059942511 0.344194428832445 0.00196174039906936 1 COL6A1|COLLAGEN_VI 4.69159649281957e-05 0.338085110051567 0.000186294445008127 1 GSK3A GSK3B|GSK3-ALPHA-BETA 1.01253437599281e-08 0.327535036037461 4.43490056684851e-07 1 EIF4EBP1|4E-BP1_PT70 0.00030093793369302 0.291665446687304 0.000941505821125305 1 LCK|LCK 2.21433816308315e-05 0.28945217154279 0.000107764457270047 1 G6PD|G6PD 0.0168636999146167 0.27667637178511 0.0297834700104924 1 MAPK1|ERK2 1.56029323687486e-05 0.276317877473197 9.23524915879985e-05 1 TGM2|TRANSGLUTAMINASE 0.00120447834889073 0.274766983009561 0.00296382874614685 1 BID|BID 1.29623588459769e-06 0.268637686262539 1.23424199446476e-05 1 ABL1|C-ABL 1.56241689169029e-08 0.268339184832132 4.88813284685962e-07 1 STK11|LKB1 7.8544679237862e-09 0.266795881611442 4.30032118827294e-07 1 SRC|SRC 3.28731705271987e-05 0.261303912660345 0.000141143706042631 1 ARAF|A-RAF 0.000743500896366509 0.247017909410502 0.00203533370380332 1 SMAD3|SMAD3 3.55697113536726e-07 0.24607647042116 5.99212829727254e-06 1 RICTOR|RICTOR_PT1135 7.98457352516848e-07 0.224682952600784 8.74310801005948e-06 1 CASP7|CASPASE-7_CLEAVEDD198 0.00902960772966489 0.22220888627069 0.0170472766620397 1 BCL2L11|BIM 0.00594709550319723 0.218735439966301 0.0118401265018199 1 ERBB3|HER3_PY1289 9.67245733154761e-07 0.218420893418966 1.00869912171854e-05 1 DPP4|CD26 0.00736217852011551 0.216348712063793 0.0143956883562973 1 BCL2L1|BCL-XL 0.000621796669437838 0.215810045491379 0.00181564627475849 1 HSPA1A|HSP70 0.0151979663279339 0.212904298510188 0.0270597937058335 1 STMN1|STATHMIN 1.9398663242125e-05 0.209918139206426 0.000103096014698492 1 PIK3R1 PIK3R2|PI3K-P85 0.000186735338831337 0.20953994074279 0.000619621806122164 1 RPTOR|RAPTOR 3.10578043590978e-05 0.207086766673824 0.000140715029251487 1 RAF1|C-RAF 0.00139485775130979 0.200458067685737 0.00339415386152049 1 CHEK2|CHK2_PT68 3.18819396933338e-06 0.199638983662226 2.4076361354621e-05 1 EIF4EBP1|4E-BP1 0.00159372669117337 0.190137811994514 0.00379376244964096 1 PRDX1|PRDX1 0.0181830584374221 0.187270432161912 0.0316038872840908 1 SMAD1|SMAD1 6.52535005000988e-06 0.186768901701411 4.46578644047551e-05 1 RPS6|S6 0.0254417435535819 0.186570382520846 0.04221016544117 1 EIF4EBP1|4E-BP1_PS65 0.000271879474444443 0.18238613569326 0.000862921810193232 1 PDK1|PDK1_PS241 0.00113477636326935 0.176522973264734 0.00288972120413939 1 ERRFI1|MIG-6 0.000449714671626737 0.175173591487304 0.00136788212619799 1 MAP2K1|MEK1_PS217_S221 0.000112394290712925 0.170624534706113 0.0003970056397763 1 CASP3|CASPASE-3 0.000266244245133804 0.169175937175392 0.000857463083592692 1 KDR|VEGFR2 0.0452903532794939 0.164980228701097 0.071356743656181 1 EEF2|EEF2 0.00793047650807964 0.162261019284483 0.0153696845599066 1 IRF1|IRF-1 0.000663368391417894 0.161428792148119 0.00191154839105946 1 RAB11A RAB11B|RAB11 0.00187142573764003 0.150801331619906 0.00436002379301241 1 CCND1|CYCLIN_D1 0.049160735220739 0.148676366102038 0.0769014358095846 1 ANXA7|ANNEXIN_VII 0.0149041094442505 0.146541077756897 0.0267540981007447 1 PCNA|PCNA 0.000467526360573316 0.145680607340596 0.00140257908171995 1 CDKN1B|P27_PT157 3.1705268347808e-05 0.145415799245611 0.000140715029251487 1 BIRC2 |CIAP 0.000242668794396753 0.143741382878213 0.000793200984669984 1 PDK1|PDK1 7.71621776321667e-06 0.127623933771317 5.12076269740743e-05 1 YBX1|YB-1_PS102 0.000784690756250059 0.12561751842931 0.00209569848315565 1 EIF4E|EIF4E 0.0258491268664532 0.120674756693574 0.0422459610727855 1 PARK7|DJ-1 0.0253433023857715 0.119826514627743 0.04221016544117 1 YAP1|YAP 0.0179970950960247 0.116724303783856 0.0315309106082353 1 CASP8|CASPASE-8 0.00161409631567899 0.111019517147179 0.00380093648530859 1 MRE11A|MRE11 0.00536518976679337 0.10870170197163 0.0109810893357733 1 IGFR1|IGF1R_PY1135_Y1136 0.000969788647489459 0.097461187026489 0.00252837754524038 1 CDKN1B|P27_PT198 0.000936675691564579 0.0893251056659875 0.00247146959581497 1 EGFR|EGFR_PY1173 0.000580151138758856 0.0861186376697492 0.00171693377551607 1 MYC|C-MYC 0.0193240571889334 0.0848789376612853 0.0333225868061135 1 ADAR|ADAR1 0.0030318459753894 0.076893190418652 0.00670681079404322 1 MET|C-MET_PY1235 0.000164507177596699 0.0683561432788401 0.000554262644518109 1 RAF1|C-RAF_PS338 0.0125166293383265 0.0656304957042319 0.0228428485424459 1 YWHAE|14-3-3_EPSILON 0.0279193200853137 -0.0755402077550157 0.0452736089808676 1 CHEK1|CHK1_PS345 0.0198704868610129 -0.0961702269390282 0.0339971611137643 1 CTNNA1|ALPHA-CATENIN 0.00277168291132626 -0.101785399548119 0.00625771708845826 1 NOTCH1|NOTCH1 0.00314724480708587 -0.104831583047806 0.00689246612751806 1 FOXO3|FOXO3A_PS318_S321 0.000674651036167941 -0.110673096616771 0.00191881268728285 1 RPS6KA1|P90RSK 0.0250814811992748 -0.116576491932759 0.04221016544117 1 PGR|PR 9.0244327375738e-05 -0.12450400761489 0.000334974706699773 1 CDK1|CDK1_PY15 0.00437450640786159 -0.126441231741536 0.00921170099347777 1 SMAD4|SMAD4 0.000715109946574383 -0.126967541796395 0.00198239339619987 1 RICTOR|RICTOR 0.00549790151707532 -0.128857871439028 0.0111485225207361 1 RPS6KA1|P90RSK_PT359_S363 0.0256450429753074 -0.13328082554906 0.0422275519668596 1 ERCC1|ERCC1 0.0112446653189597 -0.139718528204232 0.0206939639063208 1 AR|AR 0.00883840420890805 -0.14362044508511 0.0168313958413119 1 GATA3|GATA3 0.00392708402574417 -0.150085206713323 0.00834981943337838 1 PECAM1|CD31 0.00342728897386438 -0.160666195162853 0.00743144836907227 1 PRKCD|PKC-DELTA_PS664 1.8222769100248e-05 -0.161164587420846 0.000102327857255239 1 GUSP4|DUSP4 0.00300825723607919 -0.169573603498903 0.00670681079404322 1 RBM15|RBM15 0.0377081595775958 -0.177333909881034 0.0598412097644455 1 SRSF1|SF2 0.00115644028763479 -0.183839508871003 0.00291103934473585 1 PARP1|PARP_CLEAVED 0.000111671901911439 -0.186387316983229 0.0003970056397763 1 RPS6KB1|P70S6K 0.00579842645379538 -0.188673988862539 0.0116500494805614 1 JUN|C-JUN_PS73 0.000390749582051517 -0.191386219947806 0.00120526983759552 1 NKX2-1|TTF1 0.000114701073938436 -0.192960679884169 0.000398722780833611 1 ERBB2|HER2_PY1248 1.38516855663375e-06 -0.194793764636834 1.2639663079283e-05 1 NFKB1|NF-KB-P65_PS536 0.0146235436356543 -0.196295694867241 0.026467405423209 1 SHC1|SHC_PY317 0.0011994813065336 -0.203618696777273 0.00296382874614685 1 PXN|PAXILLIN 0.00226459110946504 -0.204191908226802 0.00516609846846712 1 ARAF|A-RAF_PS299 4.54317506029221e-07 -0.209052252980721 6.21847086377496e-06 1 ERBB3|HER3 0.0106012110868235 -0.212058802644357 0.019675129050969 1 RPS6KB1|P70S6K_PT389 0.00110476382406328 -0.215765073836207 0.00284639149964539 1 FOXM1|FOXM1 2.91560835623079e-05 -0.217842543380408 0.000135854942556286 1 PREX1|PREX1 0.000782245229867975 -0.219344055275078 0.00209569848315565 1 BCL2|BCL-2 1.97718384353272e-05 -0.222119487645298 0.000103096014698492 1 MTOR|MTOR_PS2448 0.000116555821546292 -0.225489739798903 0.000398839451853718 1 STAT5A|STAT5-ALPHA 0.00948387436997646 -0.228817386965674 0.0177518674104688 1 EEF2K|EEF2K 0.00469564746263649 -0.229209240520846 0.00979377899349896 1 TSC2|TUBERIN 0.0281151179059269 -0.237693833692947 0.0452736089808676 1 ANXA1|ANNEXIN-1 0.00375035039841921 -0.243002180076959 0.00805222291425301 1 SNAI1|SNAIL 6.17507859556351e-07 -0.245695852139969 7.51301229126894e-06 1 CHEK1|CHK1 4.29636192136497e-06 -0.258614567180094 3.13634420259643e-05 1 MET|C-MET 0.000107439452233981 -0.262619810839655 0.000392154000654031 1 CTNNB1|BETA-CATENIN 0.020312118938246 -0.288463778187931 0.0344833647091153 1 BECN1|BECLIN 6.81689523247694e-08 -0.289036683138401 1.65877783990272e-06 1 AKT1 AKT2 AKT3|AKT 0.0020345170496504 -0.292266538071317 0.00469009719866776 1 TSC2|TUBERIN_PT1462 2.89133722182926e-07 -0.31368233514279 5.2766904298384e-06 1 MAPK1 MAPK3|MAPK_PT202_Y204 0.00839859670409154 -0.316151268776332 0.0161341462999653 1 INPP4B|INPP4B 5.53821166727513e-07 -0.319119710373824 7.13451973607796e-06 1 BAP1|BAP1-C-4 4.76369357098407e-05 -0.32174366178605 0.000186294445008127 1 EGFR|EGFR_PY1068 1.75693012916494e-05 -0.347392463058464 0.000101254657443979 1 MSH2|MSH2 4.13599951514457e-07 -0.353537106206426 6.21847086377496e-06 1 PTPN11|SHP-2_PY542 1.43686476281998e-08 -0.365182324823981 4.88813284685962e-07 1 COPS5|JAB1 1.12490116741108e-06 -0.367052737755643 1.11978798028648e-05 1 SRC|SRC_PY416 5.62114211808097e-06 -0.377140228905486 3.97106491567656e-05 1 FOXO3|FOXO3A 1.44021363567329e-07 -0.382406313088872 3.1540678621245e-06 1 RPS6|S6_PS240_S244 0.00605782749860729 -0.386963743628683 0.0119519299296847 1 GSK3A GSK3B|GSK3_PS9 5.84961560819543e-05 -0.392242138578527 0.000224748389156982 1 TP53|P53 6.87087733482698e-07 -0.393709282866301 7.91959019119531e-06 1 XBP1|XBP1 4.61659294279065e-08 -0.401982229184483 1.26379231808894e-06 1 DIRAS3|DIRAS3 4.46263039202572e-07 -0.404044004760658 6.21847086377496e-06 1 ESR1|ER-ALPHA 2.31273258883872e-06 -0.405649124182602 1.94803244982954e-05 1 PTEN|PTEN 8.71612240217564e-06 -0.423982374383542 5.54501222551333e-05 1 RB1|RB_PS807_S811 1.97893338745047e-06 -0.437061555119279 1.73354564740661e-05 1 AKT1 AKT2 AKT3|AKT_PS473 1.8769369765985e-05 -0.495957499340909 0.000102762299468768 1 SRC|SRC_PY527 3.77806573806036e-05 -0.507890282020846 0.000154923464178283 1 PRKAA1|AMPK_PT172 0.00144357089905605 -0.554344017768495 0.00347408820761841 1 ERBB2|HER2 1.39340705660954e-09 -0.560685013387304 1.01718715132496e-07 1 EPPK1|EPPK1 2.102980879047e-07 -0.65695521712743 4.18684375010266e-06 1 CDH1|E-CADHERIN 3.13525273487093e-06 -0.687259950452508 2.4076361354621e-05 1 RAB25|RAB25 3.67685463592242e-09 0.59752445512145 9.25553063525299e-09 2 COPS5|JAB1 6.07130072708516e-26 0.537005468164264 2.6592297184633e-24 2 DIRAS3|DIRAS3 8.40914896092501e-26 0.535900777371665 3.04220808699538e-24 2 TP53|P53 6.01901624333101e-24 0.505732666678894 1.09847046440791e-22 2 FOXO3|FOXO3A 9.72395278948295e-26 0.502419569008068 3.04220808699538e-24 2 ESR1|ER-ALPHA 6.83606575979574e-23 0.500941916719772 9.35686500872042e-22 2 SETD2|SETD2 2.01736872006397e-13 0.488177881935994 7.36339582823349e-13 2 AKT1 AKT2 AKT3|AKT_PS473 2.33845389759972e-15 0.472519242456433 1.06691959077987e-14 2 MSH2|MSH2 1.24560615052586e-23 0.470602402741287 2.09836728434741e-22 2 SRC|SRC_PY416 6.87504285836359e-20 0.436425272673946 6.84379266355285e-19 2 EGFR|EGFR_PY1068 1.0556273690952e-19 0.422002382441588 9.6325997429937e-19 2 INPP4B|INPP4B 1.60807369364339e-25 0.379171556176097 4.40210173634878e-24 2 MET|C-MET 9.01786637214637e-20 0.374378617843266 8.58657711086981e-19 2 ANXA1|ANNEXIN-1 2.97523145695045e-18 0.369082532463102 2.10185706152306e-17 2 SNAI1|SNAIL 1.50043269944294e-29 0.351268743087672 3.28594761178004e-27 2 PTPN11|SHP-2_PY542 1.2376714232848e-20 0.340915153865641 1.35525020849686e-19 2 CHEK1|CHK1 3.25413550429822e-18 0.322534780404798 2.22704898575409e-17 2 RAD51|RAD51 8.22581532709217e-13 0.321107309215039 2.85945008989394e-12 2 GUSP4|DUSP4 1.95881178708427e-21 0.320621497483541 2.3832210076192e-20 2 MAPK1 MAPK3|MAPK_PT202_Y204 1.01947929924084e-08 0.317971881354238 2.35016806877625e-08 2 NKX2-1|TTF1 9.71232805318584e-27 0.310923265727947 5.31749960911925e-25 2 RB1|RB_PS807_S811 2.8549171717495e-09 0.308694176601657 7.53285374232699e-09 2 PARP1|PARP_CLEAVED 1.79817580659055e-24 0.307733649006992 3.9380050164333e-23 2 RPS6KB1|P70S6K_PT389 4.11860759996807e-19 0.302198118955787 3.60790025757203e-18 2 SRSF1|SF2 4.04162172046786e-18 0.301448846243653 2.68216714176503e-17 2 TSC2|TUBERIN_PT1462 2.52486477528254e-17 0.29822348999559 1.38236346446719e-16 2 PECAM1|CD31 6.40248295069445e-20 0.297097436040555 6.67687507715278e-19 2 EPPK1|EPPK1 0.000183175186090384 0.289203375445245 0.000274762779135576 2 BCL2|BCL-2 2.17266779654808e-21 0.28832146357756 2.50428551286331e-20 2 ARAF|A-RAF_PS299 2.22072966618305e-27 0.276896380768395 2.43169898447044e-25 2 RPS6|S6_PS240_S244 0.000739980526324363 0.266670646594557 0.00106615615305944 2 SRC|SRC_PY527 3.63162454846817e-05 0.258962718228808 6.07118913064526e-05 2 GSK3A GSK3B|GSK3_PS9 6.39100155877971e-08 0.251418166402861 1.3204050390309e-07 2 FOXM1|FOXM1 1.83228618090426e-16 0.250161480981175 9.33187613065193e-16 2 PREX1|PREX1 1.3210449957899e-12 0.24266339862941 4.45090544735366e-12 2 XBP1|XBP1 5.85881578405768e-09 0.230822853780443 1.4256451741207e-08 2 RPS6KA1|P90RSK_PT359_S363 2.02765400472658e-14 0.221838837186639 8.53954282759848e-14 2 BECN1|BECLIN 2.18707465634527e-14 0.214287429579066 9.03715754225687e-14 2 SCD|SCD 6.52737157209308e-09 0.21126838076065 1.55379823292216e-08 2 IGFBP2|IGFBP2 0.00538869935754377 0.207602988484617 0.00728472320556843 2 BAP1|BAP1-C-4 1.95002596991123e-08 0.206599256314006 4.22827413277782e-08 2 RPS6|S6_PS235_S236 0.000534072909066748 0.201338372208369 0.000779746447237452 2 AR|AR 1.78998022360631e-05 0.198053821652646 3.08665881078568e-05 2 PGR|PR 4.52294497612306e-22 0.196292532132853 5.82661735159382e-21 2 JUN|C-JUN_PS73 3.03101706459135e-13 0.194843436431476 1.08818481499263e-12 2 SHC1|SHC_PY317 5.6918670569209e-09 0.191276250183412 1.40058301737717e-08 2 CDH1|E-CADHERIN 0.0129738365968287 0.184485574565512 0.0166156152906754 2 SMAD4|SMAD4 5.35715634653562e-16 0.173369574530013 2.55047226063326e-15 2 PTEN|PTEN 0.000115145062082361 0.173018928169643 0.000175116448583591 2 BRCA2|BRCA2 2.82310705251934e-16 0.16620158841577 1.37391209889275e-15 2 CDK1|CDK1_PY15 4.65609719590506e-11 0.162865254748602 1.37795308905839e-10 2 ACVRL1|ACVRL1 5.43070463538552e-12 0.162366501888447 1.7236584277528e-11 2 FOXO3|FOXO3A_PS318_S321 1.4333215584979e-18 0.161349970692448 1.20729777427323e-17 2 ERBB2|HER2 0.00405176746978404 0.160482097406304 0.00558073632630632 2 NRAS|N-RAS 6.42610597466124e-15 0.151587843344987 2.81463441690162e-14 2 YWHAE|14-3-3_EPSILON 1.34826642140527e-13 0.147405190359617 5.00458214047041e-13 2 CTNNA1|ALPHA-CATENIN 4.324927131466e-14 0.147157184125968 1.75399822553899e-13 2 BAK1|BAK 1.17463461063668e-15 0.143099341104238 5.47329744105177e-15 2 ITGA2|CD49B 2.94454368792726e-08 0.141055445210305 6.14147683481971e-08 2 PARP1|PARP1 6.48348753675445e-05 0.140741894159746 0.00010364115113498 2 ERBB2|HER2_PY1248 7.86130674714743e-07 0.139807636425882 1.48416049795283e-06 2 ERCC1|ERCC1 3.32770059772142e-09 0.138538470907164 8.47402826629059e-09 2 PRKCD|PKC-DELTA_PS664 4.1510505836231e-12 0.136969316598214 1.33688246737273e-11 2 CCNE1|CYCLIN_E1 0.00708770377426969 0.134661606886295 0.00946467760100648 2 STAT3|STAT3_PY705 2.97536486385232e-06 0.133689339242362 5.47567147213158e-06 2 NDRG1|NDRG1_PT346 0.0178069317293176 0.130158559423946 0.022284103135546 2 NOTCH1|NOTCH1 2.1895895586732e-11 0.121005937116071 6.75380441337226e-11 2 MAPK8|JNK_PT183_PY185 2.90629808161389e-11 0.119547286168137 8.83998999824225e-11 2 MTOR|MTOR_PS2448 6.74539621144074e-06 0.116637818162973 1.20100956935408e-05 2 YWHAB|14-3-3_BETA 6.01609043636664e-14 0.115280328237844 2.39549782829872e-13 2 PRDX1|PRDX1 0.0111097494997987 0.114065982073042 0.0144823520265233 2 CHEK1|CHK1_PS345 2.41154657755094e-08 0.107081519898989 5.07816058157361e-08 2 NRG1|HEREGULIN 4.17981484101729e-06 0.106703089627259 7.56511942299824e-06 2 AKT1 AKT2 AKT3|AKT_PT308 0.0113980674748977 0.105356150522483 0.0147702767869976 2 RB1|RB 1.12627357430167e-08 0.104518569774634 2.56931159137568e-08 2 CDK1|CDK1 1.94749716455771e-08 0.101171810585305 4.22827413277782e-08 2 MAPK14|P38_PT180_Y182 0.02993313923299 0.100591479634789 0.0358216256394798 2 CDKN1B|P27 5.36812170743383e-05 0.0835268243884467 8.64425480829418e-05 2 MYC|C-MYC 0.000926608714184661 0.0683964924906412 0.00132632227716628 2 PIK3CA |PI3K-P110-ALPHA 0.0175497915130711 0.0352009273101334 0.022088530697486 2 AKT1S1|PRAS40_PT246 0.0228293140527684 0.0327380844947289 0.0280877515593049 2 MET|C-MET_PY1235 0.00983964263325388 0.0316555040338855 0.0129812152812205 2 RAF1|C-RAF_PS338 0.0368537554029738 0.030991514846278 0.043863980615496 2 MAP2K1|MEK1_PS217_S221 0.0278906907857238 -0.0431545252795826 0.0338552912685711 2 STMN1|STATHMIN 0.028680589852952 -0.0496395278748924 0.034511259218662 2 CASP8|CASPASE-8 0.00413642854016346 -0.051174489565512 0.00566173656434874 2 ADAR|ADAR1 0.000488121808118285 -0.0519786372795826 0.000717440778375197 2 PCNA|PCNA 0.021120142366073 -0.0543214669512693 0.0261317015715818 2 BIRC2 |CIAP 0.000957621782477506 -0.0581491516677065 0.00136181279456217 2 CASP3|CASPASE-3 0.00178442403931996 -0.0622494350334552 0.00252121848136175 2 BAD|BAD_PS112 0.00341285145903113 -0.0625508323361661 0.00479111839440909 2 MAPK9|JNK2 0.00354239757435752 -0.0673211214248064 0.00494130617060062 2 ESR1|ER-ALPHA_PS118 8.03106676692653e-05 -0.0703991437195568 0.000124737845528859 2 IRS1|IRS1 0.0180829881973988 -0.0707075079624569 0.0225009909956269 2 CCNE2|CYCLIN_E2 0.000554846982203868 -0.0781027860319492 0.000804711848361901 2 EGFR|EGFR_PY1173 2.60385106129647e-09 -0.0840072891100473 7.04004175832009e-09 2 EGFR|EGFR 0.0057964750135229 -0.0919373060330249 0.00778790201203384 2 YAP1|YAP 7.42607663562375e-05 -0.0953255960549699 0.000116165055942972 2 CDKN1B|P27_PT157 6.18213647476103e-09 -0.0996383468303571 1.48778888788205e-08 2 TP53BP1|53BP1 0.00360901794379963 -0.0998624247070783 0.00500237297273493 2 PRKCB|PKC-PAN_BETAII_PS660 0.0157395355227372 -0.100038392821536 0.0200404551132526 2 CHEK2|CHK2_PT68 9.05781921139223e-06 -0.102806284001614 1.58692992583592e-05 2 MS4A1|CD20 1.02025224381851e-06 -0.103583650719342 1.9097029179167e-06 2 CASP7|CASPASE-7_CLEAVEDD198 0.00825397203550079 -0.105223982353808 0.010955271974392 2 ERRFI1|MIG-6 0.000250087903315498 -0.106810501469987 0.000372579937592477 2 CCNB1|CYCLIN_B1 0.0100987935364444 -0.11496665986435 0.0132433280507864 2 PDK1|PDK1 8.87276866505603e-11 -0.115063179598429 2.55675833900957e-10 2 YBX1|YB-1_PS102 2.73452571988557e-09 -0.116300584217836 7.30318454457244e-09 2 CLDN7|CLAUDIN-7 0.0160312557733578 -0.117132447388662 0.0202939018171408 2 ANXA7|ANNEXIN_VII 4.31162479454489e-05 -0.117958720569815 7.04661067168157e-05 2 EIF4EBP1|4E-BP1 3.5753375186213e-05 -0.121106991016889 6.02306858906204e-05 2 CDKN2A|P16_INK4A 0.0274003901348951 -0.122868921479238 0.0335233823438102 2 JAK2|JAK2 7.3428703435904e-06 -0.124800484945676 1.29684564939218e-05 2 RAB11A RAB11B|RAB11 4.91357243575914e-07 -0.134887515221493 9.52276427815267e-07 2 PXN|PAXILLIN 0.00458640857203868 -0.137349348847569 0.00623865513836317 2 GAB2|GAB2 7.22564942969634e-05 -0.143605279038619 0.000113842965834784 2 SRC|SRC 3.38747104808283e-06 -0.143968413823472 6.18213466275116e-06 2 MSH6|MSH6 2.47946029632768e-05 -0.146513939184058 4.24220160074814e-05 2 RBM15|RBM15 0.000102040760078594 -0.168764220100796 0.000156272212987497 2 CTNNB1|BETA-CATENIN 0.0279808571671752 -0.168809462236984 0.0338552912685711 2 COL6A1|COLLAGEN_VI 4.19241751109848e-05 -0.173143801378765 6.90330402203434e-05 2 TGM2|TRANSGLUTAMINASE 0.0129407875094832 -0.177372810370805 0.0166156152906754 2 MTOR|MTOR 2.65581914211518e-07 -0.177814956225151 5.23985938849752e-07 2 MAP2K1|MEK1 3.02751411014559e-05 -0.177873439176312 5.13973325675879e-05 2 PRKCA |PKC-ALPHA 0.000158004867636086 -0.181050999535822 0.000238641834567606 2 YAP1|YAP_PS127 3.75909221611648e-05 -0.185605859126614 6.23667572219325e-05 2 TSC2|TUBERIN 0.000393655031068252 -0.198115641030873 0.000582503052729373 2 SMAD1|SMAD1 2.70769724688716e-18 -0.198486340206003 1.97661899022763e-17 2 STAT5A|STAT5-ALPHA 9.59644564794247e-05 -0.201326266276355 0.000148001520908409 2 PDK1|PDK1_PS241 1.22674147262789e-12 -0.209811947533025 4.19775597664856e-12 2 ERBB3|HER3_PY1289 5.95688115128192e-15 -0.214189732164049 2.66236116761376e-14 2 NF2|NF2 3.38383770048357e-11 -0.21550279676904 1.01515131014507e-10 2 EIF4EBP1|4E-BP1_PT70 1.30348557060654e-08 -0.223938511523128 2.94292103054466e-08 2 DIABLO|SMAC 4.24227039970398e-06 -0.225259787367147 7.61522309455059e-06 2 HSPA1A|HSP70 6.95205773609689e-05 -0.228001191065727 0.000110326133638059 2 EIF4EBP1|4E-BP1_PS65 9.80106496544071e-18 -0.228368208303464 6.13266636409004e-17 2 CCND1|CYCLIN_D1 1.19674602061536e-07 -0.232915229837027 2.42673498624781e-07 2 BCL2L11|BIM 5.56469093100163e-09 -0.235602722993653 1.38484922032881e-08 2 MAPK14|P38_MAPK 1.05404311059219e-09 -0.241671435218911 2.92196761037582e-09 2 PDCD4|PDCD4 1.65494257703035e-07 -0.242415652924161 3.325068113483e-07 2 STK11|LKB1 1.85023924623083e-18 -0.243002896236553 1.44715141044483e-17 2 RICTOR|RICTOR_PT1135 2.17312966443412e-17 -0.243571213140383 1.25433639912274e-16 2 EEF2|EEF2 4.91610742814057e-11 -0.243632357706003 1.43550336901705e-10 2 BID|BID 7.20332303863517e-15 -0.250727187699763 3.09319165776687e-14 2 IRF1|IRF-1 6.01505007448354e-17 -0.251663554277431 3.13641896740927e-16 2 TIGAR|TIGAR 2.76889925515157e-06 -0.255599415212457 5.13888929557791e-06 2 ARAF|A-RAF 1.59739741934223e-10 -0.268849201111553 4.48500044661472e-10 2 ERCC5|ERCC5 2.15921772682306e-07 -0.271469923408025 4.29880620158409e-07 2 BRAF|B-RAF_PS445 1.69091262658169e-09 -0.272011632172655 4.62887331526738e-09 2 RPTOR|RAPTOR 2.29210048703562e-18 -0.275065653134789 1.73093105745104e-17 2 COG3|COG3 4.11497007707739e-07 -0.280314180168567 8.04623613285668e-07 2 LCK|LCK 1.98885884848244e-11 -0.280793414363059 6.22228696882363e-11 2 GSK3A GSK3B|GSK3-ALPHA-BETA 2.34547435536424e-16 -0.284039479954712 1.1674065541472e-15 2 EIF4EBP1|4E-BP1_PT37_T46 5.24927949266837e-07 -0.288573565405228 1.0084142183284e-06 2 YWHAZ|14-3-3_ZETA 7.21980369862469e-09 -0.288997790707078 1.70014732257936e-08 2 BAX|BAX 1.66912298835455e-12 -0.297336257110693 5.53845355226737e-12 2 BRAF|B-RAF 9.96137101009383e-09 -0.306245639468911 2.32078750128782e-08 2 DPP4|CD26 7.20849137287142e-07 -0.30783660244503 1.37274748752943e-06 2 CAV1|CAVEOLIN-1 5.18426391450877e-05 -0.311132979226011 8.41002812798089e-05 2 PIK3R1 PIK3R2|PI3K-P85 1.58289828251826e-18 -0.314563920812715 1.28390638470926e-17 2 TFRC|TFRC 2.08701945508679e-08 -0.319375947693739 4.48095353592164e-08 2 ABL1|C-ABL 3.8272991335588e-27 -0.321296350254841 2.79392836749792e-25 2 RPS6|S6 1.21625710131297e-13 -0.32228624192287 4.67298781030773e-13 2 YBX1|YB-1 2.19340920581464e-08 -0.324133172457724 4.6636564667321e-08 2 TSC1|TSC1 6.18355087593195e-14 -0.332662501306261 2.41821007469482e-13 2 ATM|ATM 1.01534137929315e-07 -0.350610361573688 2.07812861743177e-07 2 KDR|VEGFR2 2.4423036589116e-12 -0.356622461969127 7.98305225823344e-12 2 PRKAA1|AMPK_ALPHA 1.2460868580241e-13 -0.36272673184886 4.70505210184962e-13 2 CHEK1|CHK1_PS296 1.53946361671416e-23 -0.364263573640383 2.24761688040267e-22 2 SMAD3|SMAD3 6.146779920887e-25 -0.376130872475581 1.49571644741584e-23 2 PEA15|PEA15 4.23422142268039e-17 -0.377654377022268 2.26169388187074e-16 2 ARID1A|ARID1A 7.42283349444651e-13 -0.383812761308627 2.62193634723191e-12 2 BCL2A1|BCL2A1 2.45352473170835e-17 -0.386154429324763 1.37774850319007e-16 2 ACACA|ACC1 1.73790595936838e-05 -0.394397551533886 3.02064607223552e-05 2 RAF1|C-RAF 1.44834059218184e-23 -0.409959190303464 2.24761688040267e-22 2 BCL2L1|BCL-XL 1.65311976090519e-17 -0.415469145874032 1.00564785455066e-16 2 MAPK1|ERK2 2.30590344378925e-24 -0.444075166994514 4.5908441289986e-23 2 XRCC5|KU80 2.17647411719928e-17 -0.448458287921794 1.25433639912274e-16 2 GAPDH|GAPDH 2.91686019797029e-09 -0.469595284235693 7.60467123042254e-09 2 SYK|SYK 1.10399125495056e-10 -0.471279989693094 3.13992317966458e-10 2 FN1|FIBRONECTIN 1.68048219834446e-08 -0.499256476565512 3.75536327997384e-08 2 PEA15|PEA15_PS116 2.96946008666007e-09 -0.53201300403281 7.6507265762183e-09 2 SERPINE1|PAI-1 1.71505077076263e-08 -0.603384273807552 3.79390018986885e-08 2 BRD4|BRD4 4.46932136963012e-18 -0.656184527772698 2.87876876455587e-17 2 MYH11|MYH11 0.000715360166268026 0.945870518824176 0.0116429540893954 3 SYK|SYK 4.30624578814068e-05 0.713202672030525 0.00188613565520562 3 STAT5A|STAT5-ALPHA 0.000122748042972333 0.568519824933455 0.0029868690456601 3 HSPA1A|HSP70 0.0151974361863811 0.54670396580525 0.0564108224545332 3 ATM|ATM 6.7871738987194e-07 0.495131435760073 0.000148639108381955 3 PDCD4|PDCD4 5.22745767828808e-06 0.426262206301587 0.00038160441051503 3 CAV1|CAVEOLIN-1 0.00451850602288281 0.404958565016484 0.0267446707840901 3 SERPINE1|PAI-1 0.0499057465967186 0.358956400900488 0.121437316718682 3 BCL2L1|BCL-XL 0.000609279114978268 0.350280415174603 0.0116429540893954 3 BRD4|BRD4 0.00169129140958268 0.350241362266178 0.0161944849160098 3 SRC|SRC_PY527 0.00523085399753549 0.347018631111111 0.0291412252434919 3 LCK|LCK 0.0039758931242329 0.339425200909646 0.0263854725517274 3 PRKAA1|AMPK_PT172 0.0056885711192508 0.336461395041514 0.0303852945150226 3 PXN|PAXILLIN 0.00254983636211376 0.308950751673382 0.0223924780086166 3 CCND1|CYCLIN_D1 0.0368947689611816 0.240012146506105 0.0982834478324167 3 MAP2K1|MEK1 0.00050286136256029 0.23511102502381 0.0110126638400704 3 MAPK1 MAPK3|MAPK_PT202_Y204 0.0125765192468002 0.229276979861416 0.0489542924315663 3 YAP1|YAP_PS127 0.00828279196141539 0.21349795226862 0.0386071447945881 3 XBP1|XBP1 0.0192338783557403 0.211230736106227 0.0629660481605132 3 TSC2|TUBERIN 0.0015465360996935 0.209660128137363 0.0161944849160098 3 PRKCB|PKC-PAN_BETAII_PS660 0.00532259821798939 0.192181266666667 0.0291412252434919 3 NFKB1|NF-KB-P65_PS536 0.0171757025208464 0.190169114888889 0.0606690137429897 3 PIK3R1 PIK3R2|PI3K-P85 0.00448915389847133 0.188631415601343 0.0267446707840901 3 MAPK14|P38_PT180_Y182 0.00895313255283293 0.187803832 0.040015021001437 3 RICTOR|RICTOR_PT1135 0.0282307510394047 0.187191178683761 0.0835477632112112 3 GAB2|GAB2 0.0161264201955255 0.186817645673382 0.0588355002633927 3 MAPK1|ERK2 0.00366841853882714 0.184988656871184 0.0251057393750982 3 XRCC5|KU80 0.0330852378875288 0.183522308371795 0.0928931679149847 3 RAF1|C-RAF 0.0010508385943293 0.173895390923687 0.0135372736563598 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.000885942346387614 0.172388749143468 0.0129347582572592 3 MAPK14|P38_MAPK 0.0031548726392207 0.17068607367094 0.0238247278617012 3 AKT1 AKT2 AKT3|AKT 0.000685115330358 0.168277604605006 0.0116429540893954 3 CHEK1|CHK1_PS296 0.0373328516794644 0.162845690057387 0.0982834478324167 3 ARID1A|ARID1A 0.0435054912437327 0.148862342727106 0.109513822785948 3 PTEN|PTEN 0.00780815616749938 0.148052695724054 0.037999693348497 3 PEA15|PEA15 0.0300078616046702 0.142788665283883 0.0864700222555628 3 IRF1|IRF-1 0.0266057858540309 0.139076583162393 0.0798173575620927 3 BRAF|B-RAF_PS445 0.0288378347003786 0.134127000985958 0.0842064773251055 3 ETS1|ETS-1 0.0347661794142841 0.121794189175824 0.0951724161466027 3 ABL1|C-ABL 0.0114703372067912 0.120108781157509 0.0474238508483223 3 SMAD3|SMAD3 0.0310728737466467 0.111229950281441 0.0883760954612419 3 BAD|BAD_PS112 0.00125100898070964 0.105427652291819 0.0144195245671269 3 NF2|NF2 0.0174862380899317 0.100724468687424 0.0607854943126197 3 BAX|BAX 0.0467132219417695 0.0981016718601953 0.114946018036489 3 BIRC2 |CIAP 0.0184285678436145 -0.0577010243125763 0.0629660481605132 3 ESR1|ER-ALPHA_PS118 0.00747262376449795 -0.0725727886184371 0.037999693348497 3 PGR|PR 0.0417355622311833 -0.0748190827912088 0.106280094518944 3 ERCC1|ERCC1 0.0198237143080504 -0.0801997495390721 0.0638440210803388 3 CASP3|CASPASE-3 0.00828555162258284 -0.0846549394590965 0.0386071447945881 3 EEF2K|EEF2K 0.00430392734449762 -0.0930309200647131 0.0267446707840901 3 IRS1|IRS1 0.00263187714813296 -0.0935765890427351 0.0223924780086166 3 CHEK1|CHK1_PS345 0.00304033328446345 -0.102112002294872 0.0237797496177677 3 CCNE2|CYCLIN_E2 0.00265846770878553 -0.102606074148962 0.0223924780086166 3 CTNNA1|ALPHA-CATENIN 0.0215991707914374 -0.103799468667888 0.0666227944130252 3 NRAS|N-RAS 0.00122157786448758 -0.114900206989011 0.0144195245671269 3 PECAM1|CD31 0.0441145749894896 -0.114951330161172 0.109785135485207 3 ITGA2|CD49B 0.0107502158548668 -0.116762101636142 0.0461626916120751 3 XRCC1|XRCC1 0.0204013618842161 -0.116855007288767 0.0647521485890337 3 ARAF|A-RAF_PS299 0.0049241983323687 -0.11842754775641 0.0283789324944407 3 RPS6KB1|P70S6K_PT389 0.0211813959684826 -0.124473053650794 0.0662675102442527 3 SNAI1|SNAIL 0.0358301164769037 -0.125961569904762 0.0968740186227396 3 BRCA2|BRCA2 0.00100343619629807 -0.134464696363248 0.0135372736563598 3 SHC1|SHC_PY317 0.012062268963389 -0.136611761715507 0.0484056487574036 3 BAP1|BAP1-C-4 0.0256424031530972 -0.137681452384005 0.077995642924004 3 ACVRL1|ACVRL1 0.000744298434938518 -0.138852538345543 0.0116429540893954 3 EIF4EBP1|4E-BP1 0.00170079065327957 -0.15160742289011 0.0161944849160098 3 NKX2-1|TTF1 0.00292140199085517 -0.152673123050672 0.0236958161480475 3 ESR1|ER-ALPHA 0.0163879703929998 -0.152893088979853 0.0588355002633927 3 SCD|SCD 0.0342661070728016 -0.154947370705739 0.0949908537840956 3 PARP1|PARP_CLEAVED 0.00618157576061342 -0.158230743506715 0.0322325021803414 3 GUSP4|DUSP4 0.01274152816712 -0.169225472134921 0.0489542924315663 3 PCNA|PCNA 5.32728023433346e-05 -0.177817930076923 0.00194445728553171 3 SRSF1|SF2 0.0376977608124338 -0.178513078052503 0.0982834478324167 3 DPP4|CD26 0.0187269118150763 -0.192638026800977 0.0629660481605132 3 CCNE1|CYCLIN_E1 0.00444935824308749 -0.194216985892552 0.0267446707840901 3 MET|C-MET 0.0133928355637857 -0.196289511159341 0.0505694998011908 3 FOXO3|FOXO3A 0.019263585510294 -0.210045072957265 0.0629660481605132 3 DIRAS3|DIRAS3 0.0121566697792566 -0.230377202223443 0.0484056487574036 3 TP53|P53 0.0114770049998223 -0.237534487094628 0.0474238508483223 3 CHEK1|CHK1 0.00859043376889942 -0.248182483282662 0.0391938540706036 3 PRDX1|PRDX1 0.00164324586591102 -0.253786843648352 0.0161944849160098 3 G6PD|G6PD 8.94467931761779e-05 -0.267710819023199 0.00244860596319787 3 DIABLO|SMAC 0.00357841535255389 -0.268617768921245 0.0251057393750982 3 COPS5|JAB1 0.00766102762618523 -0.270195725477411 0.037999693348497 3 EPPK1|EPPK1 0.0400190734434022 -0.271838124351648 0.103107965695354 3 MSH2|MSH2 0.00916222319080262 -0.28511264907326 0.0401305375757155 3 AR|AR 1.11413244772466e-05 -0.3134329051221 0.000609987515129251 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.00335180120414998 -0.345096303403541 0.0244681487902949 3 SETD2|SETD2 7.10818071693072e-05 -0.43327686685348 0.00222384511001118 3 RAB25|RAB25 2.95766329424096e-06 -0.656779889406593 0.000323864130719385 3 PEA15|PEA15_PS116 7.89990227625193e-08 0.952892240724781 8.65039299249586e-06 4 CTNNB1|BETA-CATENIN 4.66728939814136e-05 0.529743345220833 0.000567853543440532 4 CAV1|CAVEOLIN-1 0.000604278489396615 0.442250838550219 0.00353606031812535 4 CDH1|E-CADHERIN 0.000119488237725404 0.434283073938377 0.00109033016924431 4 BRD4|BRD4 8.88253002742565e-05 0.42999768804057 0.000884215489093735 4 KDR|VEGFR2 4.60087152767118e-06 0.386184352207675 0.000111954540506665 4 YBX1|YB-1 0.000386426954139126 0.370806395666009 0.00248904420460202 4 ERCC5|ERCC5 1.70601531990491e-05 0.354908196691009 0.000287696446515236 4 PRKAA1|AMPK_ALPHA 2.155512902175e-06 0.335197404963816 7.86762209293875e-05 4 DPP4|CD26 0.00434420828795035 0.332529298233114 0.0159891717864304 4 XRCC5|KU80 0.00185093128793882 0.326231162716886 0.00862455217145961 4 PXN|PAXILLIN 6.63284959917882e-05 0.325217773223026 0.000726297031110081 4 ERBB2|HER2 0.00197021115459188 0.318178823913816 0.00862952485711243 4 EEF2|EEF2 4.00734807868995e-05 0.295880675776974 0.000546443932678942 4 SMAD3|SMAD3 1.70778712543291e-05 0.266964076194518 0.000287696446515236 4 IRS1|IRS1 7.53873779239446e-05 0.261899506832675 0.000786182655492565 4 MAPK1|ERK2 0.0113588407597409 0.253734866538377 0.0318921298254264 4 ARID1A|ARID1A 0.00438059500998094 0.244552362942763 0.0159891717864304 4 BCL2L1|BCL-XL 0.0275249974963466 0.226325690006798 0.060755252880266 4 RBM15|RBM15 0.000211330641841031 0.220240747532237 0.00165290752011378 4 DIABLO|SMAC 0.0112202752504159 0.219342238509868 0.0318921298254264 4 CDH3|P-CADHERIN 0.000179392357457881 0.214811130727851 0.00146445031715284 4 ERBB3|HER3_PY1289 5.7307435963623e-06 0.204896572757237 0.000125503284760334 4 CCND1|CYCLIN_D1 0.0201751877575736 0.198155162278289 0.0480257186837893 4 PEA15|PEA15 0.00795236121639228 0.187490624953728 0.0252401029911581 4 GATA3|GATA3 1.49186166975714e-05 0.185008107237939 0.000287696446515236 4 COG3|COG3 0.0384151651481028 0.182214225593202 0.0786254314713506 4 MS4A1|CD20 1.93815042774406e-05 0.180531139334868 0.000293661695731044 4 BRAF|B-RAF 0.0476834953395446 0.180008143151535 0.0940782475618042 4 NF2|NF2 0.00327019006069463 0.178521385544518 0.0125644144437215 4 ETS1|ETS-1 2.01138147760989e-05 0.17232014946557 0.000293661695731044 4 IRF1|IRF-1 0.000934851905807209 0.166056999194079 0.00493240845550327 4 RAB11A RAB11B|RAB11 0.000474513043232231 0.15842255103136 0.00296909589908167 4 EGFR|EGFR 0.00196351096408417 0.155730396544079 0.00862952485711243 4 BCL2L11|BIM 0.0289183191752247 0.148702895800658 0.062089332346806 4 JAK2|JAK2 0.000180548669238021 0.132384169788816 0.00146445031715284 4 EEF2K|EEF2K 0.0102565690307536 0.128942718289693 0.0299491815698005 4 CCNE2|CYCLIN_E2 0.000945941347630765 0.126071645771711 0.00493240845550327 4 EIF4G1|EIF4G 0.0321350420459499 0.122583813316009 0.0678482021582444 4 ERBB3|HER3 0.00886273129860864 0.120642511105044 0.0277276879199327 4 PIK3R1 PIK3R2|PI3K-P85 0.0198157204199894 0.120170293655044 0.0476883821096448 4 RPS6KB1|P70S6K 0.00675951281365213 0.119667072757237 0.0222488627980304 4 EIF4EBP1|4E-BP1_PT70 0.0473569673050395 0.117003077711184 0.0940782475618042 4 CDH2|N-CADHERIN 0.000282073061649055 0.115976652963816 0.00199270969358526 4 ESR1|ER-ALPHA_PS118 0.000317267063856755 0.114196419062939 0.00217129646826967 4 EGFR|EGFR_PY1173 0.000790809889664063 0.0781431919910088 0.00432968414591074 4 ERRFI1|MIG-6 0.0404072147093122 0.0645089643997807 0.0819368520494386 4 SMAD1|SMAD1 0.0333250867530182 0.0587327783164474 0.069506609513438 4 MET|C-MET_PY1235 0.0243962443733257 -0.0430322004690789 0.0555138608078192 4 YWHAB|14-3-3_BETA 0.0185849599306071 -0.0454999639142544 0.0457315306157635 4 BIRC2 |CIAP 0.0101358550925046 -0.0503863831019737 0.0299491815698005 4 CDKN1B|P27_PT198 0.000241896007762124 -0.0560074200129386 0.00180540765395355 4 AKT1S1|PRAS40_PT246 0.0245883310427327 -0.0574168403958333 0.0555138608078192 4 MRE11A|MRE11 0.000175923660328553 -0.0611322933510965 0.00146445031715284 4 NRG1|HEREGULIN 0.00556322032882892 -0.0645118764260965 0.0190366445627115 4 PIK3CA |PI3K-P110-ALPHA 0.0107412298769873 -0.0662174984085526 0.0309517018823713 4 BRCA2|BRCA2 0.00624288175293141 -0.0672056657703947 0.0210337092906458 4 BAK1|BAK 0.00294663655186399 -0.0712905342559211 0.0119502482381151 4 RAF1|C-RAF_PS338 1.74892513363171e-07 -0.0745723573660087 1.27671534755115e-05 4 FOXO3|FOXO3A_PS318_S321 0.0102385173851231 -0.0765694165247807 0.0299491815698005 4 RB1|RB 0.00136191640384689 -0.0789420605923245 0.0066279931653882 4 MAPK8|JNK_PT183_PY185 0.00680672971446592 -0.0822132292274123 0.0222488627980304 4 IGFR1|IGF1R_PY1135_Y1136 3.97392587642601e-06 -0.0831914585559211 0.000108786220867162 4 MAP2K1|MEK1_PS217_S221 4.62655522999164e-07 -0.0893130199971491 2.02643119073634e-05 4 NRAS|N-RAS 0.0037853760967587 -0.0919407235752193 0.0142930580205199 4 MYC|C-MYC 2.53578359120658e-06 -0.100750646221711 7.93338009248916e-05 4 JUN|C-JUN_PS73 0.0119126171092159 -0.105108254688377 0.0330235841382061 4 ITGA2|CD49B 0.016730212667514 -0.110058341866009 0.0421139836113283 4 BCL2|BCL-2 0.0126701735878374 -0.113654163891886 0.0342563952560048 4 STMN1|STATHMIN 3.87957927569029e-07 -0.114791459323903 2.02643119073634e-05 4 PTPN11|SHP-2_PY542 0.045310855801442 -0.115247077441886 0.0910374075276679 4 CDK1|CDK1 0.000247316116979938 -0.12173132275636 0.00180540765395355 4 PARP1|PARP_CLEAVED 0.0140195613985894 -0.121825648739693 0.0374424871498912 4 RPS6KB1|P70S6K_PT389 0.0207024663794222 -0.124460997551974 0.048232341883973 4 RPS6KA1|P90RSK_PT359_S363 0.00728218976230846 -0.124702655313816 0.0234529346756699 4 SNAI1|SNAIL 0.00321745849444114 -0.126867372780482 0.0125644144437215 4 CASP7|CASPASE-7_CLEAVEDD198 0.00252308208167834 -0.128782859705482 0.0106260572286069 4 TSC2|TUBERIN_PT1462 0.0206296621603971 -0.134566669074342 0.048232341883973 4 NKX2-1|TTF1 0.00189234517878147 -0.13697935584057 0.00862952485711243 4 MET|C-MET 0.0223483690330287 -0.141880436234868 0.0515188717708767 4 SRC|SRC 0.00264638640696921 -0.145070210209868 0.0109350683608728 4 PARP1|PARP1 0.0170116973521489 -0.149139147942763 0.0423359286377342 4 FOXM1|FOXM1 0.00534426960297733 -0.151224149680921 0.0185776990960641 4 CDK1|CDK1_PY15 5.05077522703607e-05 -0.15154815034364 0.000582168302484684 4 INPP4B|INPP4B 0.00528539631310748 -0.153004975229167 0.0185776990960641 4 PECAM1|CD31 0.00317439005007447 -0.153470859788377 0.0125644144437215 4 PREX1|PREX1 0.0193591727908974 -0.154927800593202 0.0471073204578503 4 GSK3A GSK3B|GSK3_PS9 0.035453977952444 -0.156909451538816 0.0732492563357098 4 FOXO3|FOXO3A 0.0274816331110263 -0.162294845901535 0.060755252880266 4 PRDX1|PRDX1 0.0322201507966092 -0.176054118722588 0.0678482021582444 4 CHEK1|CHK1 0.0101934062490868 -0.176224320738377 0.0299491815698005 4 GUSP4|DUSP4 0.00212071195165338 -0.182355951164693 0.00910658661592334 4 ANXA1|ANNEXIN-1 0.00494383755739949 -0.18785951381557 0.0177491872962375 4 RB1|RB_PS807_S811 0.0280195458488898 -0.190667927545395 0.060755252880266 4 DIRAS3|DIRAS3 0.0150074779552313 -0.19122270991557 0.0395980442433211 4 MSH2|MSH2 0.0162100457660959 -0.193854362046711 0.0417647061502942 4 SRC|SRC_PY416 0.00901206356013699 -0.198530839629605 0.0277977735164789 4 STAT3|STAT3_PY705 0.000975486772557859 -0.200025158606798 0.00496817681837607 4 COPS5|JAB1 0.0120907611483877 -0.209922030001096 0.0330984586437113 4 MAPK14|P38_PT180_Y182 0.00176422347221953 -0.210960867134868 0.00839923783513211 4 RPS6|S6_PS235_S236 0.0164921379992742 -0.22190985636864 0.0419974211841983 4 CCNB1|CYCLIN_B1 0.00120808039607242 -0.226227492502851 0.00601294560772409 4 CDKN2A|P16_INK4A 0.000613562977574262 -0.243115338348465 0.00353606031812535 4 ATM|ATM 0.027961279525154 -0.248026314095833 0.060755252880266 4 RAB25|RAB25 0.0154192814299864 -0.273902512867763 0.0402002694424645 4 RAD51|RAD51 9.79149980060302e-05 -0.273922491544079 0.000932321067970462 4 SETD2|SETD2 0.000371811969297632 -0.290676441826535 0.00246747943261156 4 MAPK1 MAPK3|MAPK_PT202_Y204 0.000640740090829666 -0.292838270094956 0.00359800204850505 4 G6PD|G6PD 7.39640865989838e-08 -0.32009042258136 8.65039299249586e-06 4 SYK|SYK 0.000559384321653598 -0.370239642235746 0.00340292129005939 4 SQSTM1|P62-LCK-LIGAND 4.24180221714247e-05 -0.423687864447149 0.000546443932678942 4 BRD4|BRD4 2.02211220667265e-05 0.541771569312815 0.000265976791128114 5 ATM|ATM 2.52481503702888e-07 0.530296757642647 1.84311497703108e-05 5 TSC2|TUBERIN 1.80478736936705e-07 0.48585621004895 1.84311497703108e-05 5 PRKAA1|AMPK_PT172 1.6359334426781e-05 0.462426823541387 0.000264645555383134 5 BRAF|B-RAF 9.3439335085267e-06 0.424384478829202 0.000227369048707483 5 ACACA|ACC1 0.000251352048728657 0.386407544110714 0.0018348699557192 5 CCNB1|CYCLIN_B1 1.1241272341724e-05 0.384657205240546 0.000246183864283756 5 ACACA ACACB|ACC_PS79 0.00110619710180807 0.371876430210714 0.00538349256213261 5 XRCC5|KU80 7.07110482465707e-08 0.368090468498109 1.5485719565999e-05 5 ARID1A|ARID1A 0.000206683222615608 0.358221509518697 0.00156081468113166 5 PRKCB|PKC-PAN_BETAII_PS660 1.69179807094241e-05 0.329638506671639 0.000264645555383134 5 TSC1|TSC1 3.22895370441764e-05 0.32779939927416 0.000353570430633732 5 COG3|COG3 3.97763543283515e-05 0.321158733916176 0.00041481055228138 5 MSH6|MSH6 3.55656284212509e-06 0.321100782001471 0.000129814543737566 5 NFKB1|NF-KB-P65_PS536 0.00373103831904794 0.314198380748529 0.0157318525453448 5 BRAF|B-RAF_PS445 7.10477807867935e-05 0.309786450006933 0.000707248363286717 5 PRKCA |PKC-ALPHA 0.000445667986332963 0.30496219835105 0.00295761481839148 5 MTOR|MTOR 4.69489854236064e-06 0.301113005348529 0.000146883254396711 5 RBM15|RBM15 2.38288962289226e-06 0.299074254867857 0.000104370565482681 5 STAT5A|STAT5-ALPHA 0.00048188866678814 0.294241526525 0.0031039299419589 5 PRKCA |PKC-ALPHA_PS657 9.01535518613896e-05 0.292820822298109 0.000759370302217089 5 RAF1|C-RAF 1.82735419155618e-05 0.265332359437185 0.000265976791128114 5 RB1|RB_PS807_S811 0.0370362361841021 0.227577897594328 0.0853782707822985 5 EIF4G1|EIF4G 1.3836395472446e-05 0.22342590590105 0.000259923461521864 5 RPS6KB1|P70S6K 5.48168641249783e-06 0.220996426393067 0.000150061165542128 5 RPS6|S6 7.47076467166351e-05 0.198575843743908 0.000711346723084482 5 TP53BP1|53BP1 0.0102436555181187 0.194298626387605 0.0356088977534602 5 EIF4EBP1|4E-BP1_PT37_T46 0.0192967687074217 0.188698123454412 0.0534935740117133 5 RPTOR|RAPTOR 0.000425692409079168 0.187067733255252 0.00291333242463556 5 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.0483904485174472 0.148336620852731 0.108137839033887 5 PRKAA1|AMPK_ALPHA 0.024212037118209 0.140723928453151 0.0609475417113537 5 PDK1|PDK1_PS241 0.000563700006681206 0.138576585561975 0.003248692143768 5 ARAF|A-RAF 0.0126278823336729 0.131069267879622 0.0408974895233119 5 MAPK14|P38_MAPK 0.027944303151171 0.130129539312815 0.0679978043345161 5 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0251485884844419 0.127135856269118 0.0618824817763233 5 RICTOR|RICTOR 0.00373541704273027 0.124910826272479 0.0157318525453448 5 EIF4EBP1|4E-BP1_PS65 0.00649856601820005 0.124429180691807 0.0241217958980646 5 EEF2K|EEF2K 0.0144794796663982 0.109856984222899 0.0446620569991719 5 ABL1|C-ABL 0.018515254574588 0.107576833807353 0.0526602695043477 5 JAK2|JAK2 0.0117773077513012 0.0935568209955882 0.039680467654384 5 BAD|BAD_PS112 0.0218284726970038 0.0903854814048319 0.0562404178899274 5 MTOR|MTOR_PS2448 0.0198426711892702 0.0799339676632353 0.0536487035858046 5 RAD50|RAD50 0.0216909018060031 0.0743726391157563 0.0562404178899274 5 PIK3CA |PI3K-P110-ALPHA 0.0202444135503309 0.0515145099787815 0.0540673971649081 5 EGFR|EGFR_PY1173 0.0222560031606139 -0.0397246626254202 0.0566751708392377 5 CHEK2|CHK2_PT68 0.0190638899073587 -0.0528866485006303 0.0534935740117133 5 CDK1|CDK1 0.0124640477595796 -0.0615049574615546 0.0408974895233119 5 CDKN1B|P27_PT198 0.00063359407979175 -0.0615085664926471 0.00355787444806137 5 IGFR1|IGF1R_PY1135_Y1136 0.0316658042101903 -0.062361943719958 0.0753783817612139 5 MET|C-MET_PY1235 0.000699101595694957 -0.0683898309661765 0.00374516013887902 5 NOTCH1|NOTCH1 0.00398092533013214 -0.0691395272065126 0.0161448638388692 5 FOXO3|FOXO3A_PS318_S321 0.00949918532837787 -0.0731523398195378 0.033553573982496 5 KIT|C-KIT 0.000167832075999503 -0.0757537196560924 0.00136130461644041 5 CTNNA1|ALPHA-CATENIN 0.030497280980468 -0.0775965118371849 0.0733945553266208 5 MAP2K1|MEK1_PS217_S221 2.45947970401266e-05 -0.0805562731884454 0.00029923669732154 5 CDH2|N-CADHERIN 8.63017010549835e-05 -0.0819779030006303 0.000756002901241655 5 RAF1|C-RAF_PS338 0.000562480552389752 -0.0819942880258404 0.003248692143768 5 EIF4E|EIF4E 0.00577502105055063 -0.0863319912031513 0.0221882387731682 5 ERBB2|HER2_PY1248 0.0132331357139637 -0.0870404354111345 0.0416033926316095 5 MRE11A|MRE11 1.42423814532528e-05 -0.0875006249955882 0.000259923461521864 5 MYC|C-MYC 0.00361004265360196 -0.0895511136733194 0.0157318525453448 5 STMN1|STATHMIN 0.000504130267237969 -0.0904046118195378 0.00315441510071758 5 GATA3|GATA3 0.0334951315934583 -0.0910003465384454 0.0788756324620147 5 RAB11A RAB11B|RAB11 0.00249435603765149 -0.0949897963237395 0.0113804994217849 5 CDKN1B|P27 0.000538526073466082 -0.0949961612186975 0.003248692143768 5 RPS6KA1|P90RSK_PT359_S363 0.0162176365532457 -0.096712999630042 0.0479954379075785 5 WWTR1|TAZ 0.00383529554314616 -0.0971159895031513 0.0158477306405473 5 RPS6KB1|P70S6K_PT389 0.0435882213816228 -0.099377531314916 0.099435630026827 5 ETS1|ETS-1 0.0059253730311092 -0.103595266558193 0.0223733912726365 5 NRG1|HEREGULIN 0.0168775388111804 -0.107151182345588 0.0486339605216909 5 CCND1|CYCLIN_D1 0.0166669757404221 -0.108232578703151 0.0486339605216909 5 YWHAE|14-3-3_EPSILON 0.000921503548829416 -0.108328874414076 0.00458657448167368 5 NKX2-1|TTF1 0.0132978880557656 -0.110600591735924 0.0416033926316095 5 BRCA2|BRCA2 0.00172603061967033 -0.11448006139937 0.00821740664582179 5 RB1|RB 0.000186421905155085 -0.115019120872899 0.00145808561532013 5 PARK7|DJ-1 0.000712448880176824 -0.115786794679202 0.00374516013887902 5 MYH9|MYOSIN-IIA_PS1943 0.000909959336964792 -0.115924835867437 0.00458657448167368 5 NRAS|N-RAS 0.00179119396936785 -0.116020335671639 0.00834620168705445 5 ARAF|A-RAF_PS299 0.0042084980157387 -0.120430652609034 0.0167574739172141 5 MAPK8|JNK_PT183_PY185 0.000422515559652829 -0.122348658221219 0.00291333242463556 5 BAK1|BAK 2.06466002245568e-05 -0.123765213691807 0.000265976791128114 5 YWHAB|14-3-3_BETA 8.85834375769596e-07 -0.124382533269958 4.84994320733854e-05 5 PARP1|PARP_CLEAVED 0.0158653073456365 -0.129666234916176 0.0478518113551413 5 INPP4B|INPP4B 0.0110101511603607 -0.132798782746849 0.0376753610018593 5 BCL2|BCL-2 0.00680368356999149 -0.134607709733403 0.0244664936658595 5 PECAM1|CD31 0.0159506037850471 -0.142194510422479 0.0478518113551413 5 SRSF1|SF2 0.0247984314849477 -0.142976528586345 0.0617142783545858 5 SNAI1|SNAIL 0.00506507020233499 -0.151413497730882 0.0198080423984172 5 PGR|PR 7.8462668255261e-05 -0.154720405982983 0.000715971847829257 5 COL6A1|COLLAGEN_VI 0.000718249889648032 -0.159354392517017 0.00374516013887902 5 ACVRL1|ACVRL1 2.96657125576502e-05 -0.169849583179622 0.000341936371059231 5 FOXO3|FOXO3A 0.048307655503729 -0.17949567370021 0.108137839033887 5 EGFR|EGFR_PY1068 0.0126987638702521 -0.180160922845168 0.0408974895233119 5 ANXA1|ANNEXIN-1 0.00292420252599245 -0.191112080553571 0.0130693949631091 5 ESR1|ER-ALPHA 0.00681486809870972 -0.195674686296429 0.0244664936658595 5 TGM2|TRANSGLUTAMINASE 0.0208037628248826 -0.216471785461555 0.0548918561283047 5 CDKN1A|P21 0.0346184777916542 -0.228074472283824 0.0806536876209816 5 SETD2|SETD2 0.019651593384876 -0.241555607302731 0.0536487035858046 5