rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(3), GOT2(6), TAT(9), TYR(29) 3808360 55 53 55 9 8 22 11 6 8 0 0.0326 0.603 1.000 2 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(6), TAT(9) 2128311 18 18 18 2 5 7 3 2 1 0 0.0759 0.623 1.000 3 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(7), IL12A(2), IL12B(3), IL2(7) 2403481 27 26 27 5 1 16 0 1 8 1 0.201 0.732 1.000 4 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(53), ATR(26), CDC25C(8), CHEK1(7), CHEK2(10), YWHAH(1) 12280972 105 90 103 9 9 26 18 19 31 2 0.000478 0.794 1.000 5 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 584333 7 7 7 3 2 1 0 2 2 0 0.742 0.926 1.000 6 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(6), SLPI(1) 1382720 7 7 6 1 1 2 1 1 2 0 0.354 0.930 1.000 7 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(9) 1324024 11 10 11 3 1 3 5 0 2 0 0.593 0.960 1.000 8 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(7), PAPSS1(5), PAPSS2(10), SULT1A2(5), SULT1E1(11), SULT2A1(6), SUOX(5) 4954097 49 45 49 7 3 21 9 7 9 0 0.0373 0.977 1.000 9 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(8), GLS2(6), GLUD1(4), GLUD2(15) 3672284 33 31 33 5 0 17 9 2 5 0 0.130 0.983 1.000 10 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(4), CD4(8), CD80(3), HLA-DRA(3), HLA-DRB1(5), IL10(2), IL2(7), IL4(1) 3223968 33 29 29 7 1 14 1 3 14 0 0.418 0.988 1.000 11 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 1235104 3 3 3 0 0 1 0 1 1 0 0.495 0.990 1.000 12 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2), CD3E(2) 923089 4 4 4 2 0 0 1 1 2 0 0.858 0.992 1.000 13 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(5), IDI1(2), SQLE(4) 2563848 15 15 15 3 2 5 4 1 3 0 0.434 0.993 1.000 14 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(8), ALDH1A2(8), RDH5(1) 3156193 17 17 17 2 1 7 3 4 2 0 0.122 0.993 1.000 15 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(7), CDK2(1), CDKN1B(5), CKS1B(1), CUL1(14), E2F1(3), NEDD8(3), SKP2(3), TFDP1(10), UBE2M(1) 5488264 48 38 48 6 5 13 12 6 12 0 0.0228 0.995 1.000 16 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), FBXW7(15), TFDP1(10) 5194496 52 38 52 6 6 19 10 6 11 0 0.00765 0.995 1.000 17 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(5) 1692843 8 7 8 2 0 4 0 2 2 0 0.527 0.995 1.000 18 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(4), CD4(8), HLA-DRA(3), HLA-DRB1(5) 1927106 20 20 16 6 1 9 1 2 7 0 0.708 0.996 1.000 19 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(5), GGPS1(2), IDI1(2), IDI2(1), SQLE(4) 3440819 18 18 18 3 2 7 5 1 3 0 0.308 0.997 1.000 20 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(8), HLCS(3), SPCS1(1), SPCS3(2) 2479058 14 14 14 3 1 6 5 1 1 0 0.385 0.997 1.000 21 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(6), PGLYRP2(9) 1454837 15 15 14 5 0 4 4 3 4 0 0.632 0.998 1.000 22 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1) 11082061 102 86 100 12 10 26 15 16 33 2 0.00197 0.998 1.000 23 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(8), GLUD1(4), OAT(3), PRODH(4) 4404565 27 26 27 4 3 11 6 2 5 0 0.131 0.999 1.000 24 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NFS1(5), PHPT1(1), THTPA(1), TPK1(11) 5148488 43 39 41 7 2 17 12 6 6 0 0.111 0.999 1.000 25 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(13), CYP2C9(8) 1642731 21 21 21 7 3 9 4 2 3 0 0.625 0.999 1.000 26 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(2), HGD(5) 1795382 9 8 9 4 0 2 0 2 5 0 0.846 0.999 1.000 27 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(7), CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), SKP2(3), TFDP1(10) 5427356 47 36 47 6 5 19 12 6 5 0 0.0164 0.999 1.000 28 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(5), TGDS(1), UGDH(6), UGP2(4), UXS1(6) 3969223 22 21 22 4 2 8 4 3 5 0 0.365 1.000 1.000 29 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(4), EHHADH(13), HADHA(3), SDS(4) 3872652 25 23 24 5 4 8 5 4 4 0 0.265 1.000 1.000 30 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(4), ALDOB(8), ALDOC(2), TPI1(9) 3157676 25 21 25 5 3 9 7 0 6 0 0.285 1.000 1.000 31 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(5), TGDS(1), UGDH(6), UXS1(6) 3115757 18 17 18 4 2 8 3 2 3 0 0.432 1.000 1.000 32 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CDK2(1), CDK4(3), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1) 12090440 106 90 103 13 12 27 15 16 34 2 0.00203 1.000 1.000 33 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(7), CCNA2(6), CCND1(3), CCNE1(7), CCNE2(3), CDK2(1), CDK4(3), CDKN1B(5), E2F1(3), E2F2(5), E2F4(5), PRB1(5) 6694029 53 47 52 8 7 22 10 3 11 0 0.0266 1.000 1.000 34 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD28(4), CD3D(2), CD3E(2), CD4(8) 2606736 20 20 20 6 1 9 1 4 5 0 0.494 1.000 1.000 35 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCR3(4), HLA-DRA(3), HLA-DRB1(5), IL3(4), IL5(2) 2466150 20 20 16 6 0 5 5 4 6 0 0.842 1.000 1.000 36 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(4), CD4(8), HLA-DRA(3), HLA-DRB1(5), IL1B(1), IL4(1), IL5(2), IL5RA(9), IL6(2) 4330878 37 36 33 9 1 11 7 5 13 0 0.548 1.000 1.000 37 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), TYR(29) 7810350 94 85 93 17 10 37 19 11 17 0 0.0332 1.000 1.000 38 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(2), CHEK1(7), NEK1(11), WEE1(4) 5532285 32 30 32 5 1 11 8 5 7 0 0.214 1.000 1.000 39 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(4), GGT1(1), SHMT1(2), SHMT2(2) 3314036 9 9 8 0 2 3 2 1 1 0 0.0776 1.000 1.000 40 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(5), COQ5(3), COQ6(1), COQ7(5), NDUFA12(5), NDUFA13(1), NDUFB11(6) 3215199 27 24 27 8 7 6 3 3 8 0 0.553 1.000 1.000 41 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(2), HMGCL(1), OXCT1(7) 2736802 12 12 12 9 1 2 3 2 4 0 0.994 1.000 1.000 42 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(17), PARK2(15), SNCA(5), SNCAIP(12), UBE2E2(4), UBE2G2(1), UBE2L3(1), UBE2L6(1) 5191088 56 53 56 13 7 26 12 2 9 0 0.175 1.000 1.000 43 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(8), ACADS(1), ACAT1(2), ECHS1(4), HADHA(3) 4325350 22 21 22 7 0 4 5 4 9 0 0.808 1.000 1.000 44 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(8), PLCD1(4), PRKCA(10), TGM2(6) 3986370 28 25 28 8 5 12 3 5 3 0 0.341 1.000 1.000 45 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(3), EGR1(6), HRAS(2), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(5), RAF1(6) 6499475 51 47 47 10 6 22 14 4 5 0 0.0444 1.000 1.000 46 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL16(28), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL9(1), LTA(3), TNF(2) 8021597 85 70 85 19 5 47 10 10 12 1 0.0488 1.000 1.000 47 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT1(2), ACAT2(2), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), SDS(4) 6711531 40 37 39 9 4 11 13 6 6 0 0.325 1.000 1.000 48 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3) 6404267 49 44 49 11 5 19 11 7 7 0 0.165 1.000 1.000 49 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3) 6404267 49 44 49 11 5 19 11 7 7 0 0.165 1.000 1.000 50 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), ARF3(1), CCND1(3), CDK2(1), CDK4(3), CDKN1A(2), CDKN1B(5), E2F1(3), E2F2(5), MDM2(5), NXT1(2), PRB1(5) 5620376 36 33 35 8 5 15 5 3 8 0 0.197 1.000 1.000 51 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(12), ESR2(6), ITPKA(2), PDE1A(17), PDE1B(13), PLCB1(52), PLCB2(12), PRL(3), TRH(4), VIP(6) 8866426 127 99 125 28 19 53 24 10 21 0 0.0217 1.000 1.000 52 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(7), ENO2(2), ENO3(3), FARS2(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3) 6722782 49 46 49 10 7 19 11 4 8 0 0.113 1.000 1.000 53 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(5), CASP3(5), CASP8(6), CFLAR(2) 3134220 18 17 18 8 1 6 7 1 3 0 0.873 1.000 1.000 54 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SEC61A2(6), SRP54(5), SRP68(4), SRP72(9), SRPR(5) 6095457 33 29 32 7 2 8 12 2 9 0 0.557 1.000 1.000 55 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(34), RANGAP1(4) 6781581 39 36 39 8 6 16 9 4 4 0 0.268 1.000 1.000 56 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 EPO(6), FLT3(24), IGF1(4), IL1A(4), IL3(4), IL6(2), IL9(1), KITLG(6), TGFB1(3), TGFB2(10) 6569556 64 57 64 15 6 25 13 6 14 0 0.144 1.000 1.000 57 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(45), AKT1(3), ATM(53), BAX(3), CDKN1A(2), CPB2(6), CSNK1A1(2), CSNK1D(7), FHL2(2), GADD45A(2), HIC1(1), HIF1A(2), IGFBP3(4), MAPK8(2), MDM2(5), NFKBIB(3) 16007694 142 121 139 23 11 52 25 18 34 2 0.0116 1.000 1.000 58 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5) 4573767 48 43 45 14 3 25 7 2 11 0 0.465 1.000 1.000 59 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), PHPT1(1), TYR(29) 12088037 123 101 121 22 12 52 24 15 20 0 0.0154 1.000 1.000 60 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), SDS(4) 9729696 73 64 72 15 8 27 16 11 11 0 0.0769 1.000 1.000 61 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(10), BMPR1A(4), BMPR1B(7), BMPR2(10) 5050548 31 28 30 7 5 8 10 4 4 0 0.329 1.000 1.000 62 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(7), IFNGR1(7), JAK1(11), JAK2(16), PLA2G2A(5), PTPRU(19), REG1A(20), STAT1(7) 9229358 93 77 91 19 11 37 15 9 20 1 0.0404 1.000 1.000 63 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(7), IFNGR1(7), IFNGR2(4), JAK1(11), JAK2(16), STAT1(7) 6617914 52 50 52 12 6 15 12 7 11 1 0.404 1.000 1.000 64 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(7), NR1I3(9), PTGS1(18), PTGS2(12) 4326176 49 43 48 13 3 24 10 3 9 0 0.170 1.000 1.000 65 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(5), FARSB(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3), YARS2(10) 7030650 57 53 57 12 12 19 12 3 11 0 0.0918 1.000 1.000 66 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1E(6), PER1(10) 6788509 35 31 33 7 5 12 8 2 8 0 0.247 1.000 1.000 67 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), ST3GAL3(4) 3992736 21 19 21 6 5 6 5 2 3 0 0.439 1.000 1.000 68 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(9), CSAD(6), GAD1(7), GAD2(27), GGT1(1) 4611376 50 45 50 14 4 22 10 4 10 0 0.387 1.000 1.000 69 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(3), CDC25A(4), CDC25B(1), CDC25C(8), CDK7(3), MNAT1(2), SHH(2), XPO1(12) 6942669 37 32 37 8 3 14 8 6 6 0 0.313 1.000 1.000 70 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(9), LPL(8), NR3C1(8), PPARG(8), RXRA(1), TNF(2) 4649244 36 35 36 10 3 14 8 3 7 1 0.359 1.000 1.000 71 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), APEX1(3), CREBBP(30), DFFA(3), DFFB(4), GZMA(8), GZMB(6), PRF1(8), SET(1) 8510668 66 56 66 11 9 26 14 5 12 0 0.0283 1.000 1.000 72 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(4), MAX(8), MYC(4), SP1(6), SP3(6), WT1(16) 5031748 44 41 43 12 6 16 5 3 14 0 0.366 1.000 1.000 73 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5) 8379151 60 54 60 13 8 20 15 8 9 0 0.166 1.000 1.000 74 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5) 8379151 60 54 60 13 8 20 15 8 9 0 0.166 1.000 1.000 75 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(6), F13B(28), HSD17B1(2), HSD17B2(6), HSD17B3(3), HSD17B4(8), HSD17B7(3), HSD3B1(6), HSD3B2(15) 6540842 77 66 76 20 7 33 16 8 12 1 0.214 1.000 1.000 76 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1) 5579121 45 38 45 10 5 19 7 3 10 1 0.233 1.000 1.000 77 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), MIOX(2), UGDH(6) 6783953 44 39 44 11 4 18 12 4 6 0 0.283 1.000 1.000 78 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(10), ATM(53), BAX(3), BCL2(5), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDKN1A(2), E2F1(3), GADD45A(2), MDM2(5), PCNA(1), TIMP3(4) 12505176 102 84 99 19 11 31 21 16 21 2 0.0772 1.000 1.000 79 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 5 ADAM17(8), ERBB4(51), NRG2(3), PRKCA(10), PSEN1(6) 6213389 78 69 78 21 10 32 13 10 13 0 0.305 1.000 1.000 80 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(6), CD34(13), CD3D(2), CD3E(2), CD4(8), CD58(1), CD8A(4), IL3(4), IL6(2), KITLG(6) 4993395 48 39 47 15 4 21 6 4 13 0 0.469 1.000 1.000 81 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(8), CSF1(1), HLA-DRA(3), HLA-DRB1(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), LTA(3), PDGFA(5), TGFB1(3), TGFB2(10), TNF(2) 10608184 93 81 89 22 4 41 12 13 22 1 0.144 1.000 1.000 82 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(22), PDXK(2), PDXP(1), PNPO(2), PSAT1(5) 3885247 32 28 32 10 2 13 9 5 3 0 0.594 1.000 1.000 83 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(7), CHST11(2), CHST12(6), CHST13(3), PAPSS1(5), PAPSS2(10), SULT1A1(5), SULT1A2(5), SULT1E1(11), SULT2A1(6), SULT2B1(2), SUOX(5) 7381636 67 55 66 16 8 24 13 9 13 0 0.133 1.000 1.000 84 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(9), RAB27A(1), RAB4A(2), RAB5A(2), RAB6A(1) 3425847 15 14 15 9 1 5 5 3 1 0 0.974 1.000 1.000 85 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(4), AASS(20), KARS(8) 3810563 35 30 35 10 4 18 5 5 3 0 0.530 1.000 1.000 86 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(8), DLL1(5), FURIN(7), NOTCH1(26), PSEN1(6) 6936866 52 47 52 13 13 14 7 7 11 0 0.156 1.000 1.000 87 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(4), CD3D(2), CD3E(2), IFNG(7), IL2(7), IL2RA(6), IL4(1), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), TOB1(4), TOB2(4) 8525310 83 75 83 21 5 36 14 5 22 1 0.238 1.000 1.000 88 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(3), CAMP(4), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7) 4773910 24 23 24 8 3 8 7 3 3 0 0.607 1.000 1.000 89 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), DHFR(2), FPGS(3), GCH1(3), GGH(9), SPR(3) 5125898 49 42 49 15 2 16 14 5 12 0 0.462 1.000 1.000 90 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(2), ACYP2(1), ECHS1(4), EHHADH(13), GCDH(7), HADHA(3), SDHB(1), SDS(4) 6259671 37 33 35 10 6 10 9 5 7 0 0.448 1.000 1.000 91 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(7), GGT1(1), SHMT1(2), SHMT2(2) 4406742 15 15 15 6 2 5 4 1 3 0 0.822 1.000 1.000 92 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(3), BFAR(5), CAMP(4), CREB1(2), CREB5(18), MAPK1(2), RAF1(6), SNX13(9), SRC(2) 7759959 51 43 49 11 6 24 15 1 5 0 0.185 1.000 1.000 93 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(6), CD3D(2), CD3E(2), CD4(8), CXCR3(3), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), JAK2(16), STAT4(11), TYK2(5) 11741422 89 72 89 19 7 36 15 10 20 1 0.0702 1.000 1.000 94 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(4), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8), MECR(2), PPT1(2), PPT2(6) 6827328 41 40 40 11 3 11 14 5 8 0 0.517 1.000 1.000 95 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(71), GLS(8), GLUD1(4), GOT1(3) 6263846 92 82 91 25 5 40 17 13 17 0 0.451 1.000 1.000 96 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(8), CD8A(4), CSF1(1), EPO(6), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), IL9(1) 4807995 38 33 38 13 1 18 7 4 8 0 0.623 1.000 1.000 97 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(5), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RELA(3) 6638404 80 70 79 22 7 38 12 8 15 0 0.334 1.000 1.000 98 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(8), ALOX15(5), ALOX15B(6), ALOX5(10), ALOX5AP(2), DPEP1(5), GGT1(1), LTA4H(3), PLA2G2A(5), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11) 11922131 105 86 102 23 18 37 22 13 15 0 0.0217 1.000 1.000 99 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(7), FOS(3), HRAS(2), JUN(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYC(4), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RAF1(6), RELA(3), TNF(2) 12532437 117 99 112 28 14 49 20 13 21 0 0.0664 1.000 1.000 100 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PGK1(4), PKLR(16), RPE(3), RPIA(8), TKT(3), TPI1(9) 14454299 101 84 100 20 14 32 21 14 20 0 0.0258 1.000 1.000 101 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CAMKK1(4), CAMKK2(3), CREB1(2), SYT1(6) 9210287 64 59 64 16 5 26 11 7 15 0 0.227 1.000 1.000 102 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 186 ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), ARHGAP5(17), BCAR1(3), BCL2(5), BIRC2(2), BIRC3(4), CAPN2(5), CAV1(1), CAV2(1), CAV3(3), CCND1(3), CCND2(4), CCND3(1), CDC42(1), CHAD(1), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), CRK(1), CRKL(4), DIAPH1(3), DOCK1(15), EGF(13), ELK1(3), ERBB2(12), FARP2(7), FIGF(4), FLNA(31), FLNB(16), FLNC(55), FLT1(31), FN1(25), FYN(8), GRB2(6), GSK3B(4), HGF(54), HRAS(2), IBSP(9), IGF1(4), IGF1R(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), JUN(3), KDR(56), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), MAP2K1(10), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MET(22), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARVA(3), PARVB(3), PARVG(8), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PDPK1(3), PGF(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PRKCA(10), PRKCG(20), PTEN(11), PTK2(6), PXN(1), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(7), RELN(104), RHOA(4), ROCK1(19), ROCK2(9), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SPP1(5), SRC(2), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TLN1(15), TLN2(30), TNC(26), TNN(87), TNXB(32), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCL(8), VEGFA(1), VEGFB(2), VEGFC(21), VTN(4), VWF(32), ZYX(6) 284735848 2859 469 2822 878 360 1224 522 231 511 11 0.0981 1.000 1.000 103 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY7(13), ADCY8(48), ADCY9(12), ADORA2A(3), ADORA2B(1), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), ATP2B4(13), AVPR1A(14), AVPR1B(7), BDKRB1(1), BDKRB2(3), BST1(3), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CCKAR(14), CCKBR(24), CD38(4), CHRM1(5), CHRM2(39), CHRM3(27), CHRM5(6), CHRNA7(3), CYSLTR1(5), CYSLTR2(12), DRD1(13), EDNRA(3), EDNRB(16), ERBB2(12), ERBB3(11), ERBB4(51), F2R(10), GNA11(4), GNA14(2), GNA15(1), GNAL(5), GNAQ(5), GNAS(29), GRIN1(9), GRIN2A(61), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), GRPR(7), HRH1(5), HRH2(17), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), LHCGR(14), MYLK(26), MYLK2(9), NOS1(29), NOS3(12), NTSR1(10), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), PDE1A(17), PDE1B(13), PDE1C(28), PDGFRA(41), PDGFRB(18), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PLN(1), PPID(2), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTAFR(5), PTGER3(9), PTGFR(12), PTK2B(14), RYR1(111), RYR2(359), RYR3(124), SLC25A5(3), SLC25A6(5), SLC8A1(55), SLC8A2(10), SLC8A3(28), SPHK2(4), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), TNNC1(1), TNNC2(2), TRHR(14), TRPC1(10), VDAC1(2), VDAC2(2), VDAC3(1) 212109110 2801 462 2757 931 432 1147 573 235 396 18 0.0212 1.000 1.000 104 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(17), ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA2A(3), ADRA2B(4), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), C5AR1(7), CALCR(27), CALCRL(18), CCKAR(14), CCKBR(24), CGA(2), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CRHR1(7), CTSG(12), CYSLTR1(5), CYSLTR2(12), DRD1(13), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2(9), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHB(4), FSHR(37), GABBR1(8), GABBR2(13), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GABRB1(21), GABRB2(10), GABRB3(37), GABRD(8), GABRE(6), GABRG1(34), GABRG3(28), GABRP(6), GABRQ(23), GABRR1(11), GABRR2(10), GALR1(8), GALR2(3), GALR3(1), GH1(7), GH2(7), GHR(19), GHRHR(5), GHSR(5), GIPR(3), GLP1R(11), GLP2R(17), GLRA1(10), GLRA2(22), GLRA3(9), GLRB(9), GNRHR(5), GPR156(16), GPR35(8), GPR50(21), GPR63(10), GPR83(12), GRIA1(18), GRIA2(28), GRIA3(24), GRIA4(25), GRID1(30), GRID2(54), GRIK1(31), GRIK2(41), GRIK3(22), GRIK4(25), GRIK5(15), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRIN3A(38), GRIN3B(6), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM6(17), GRM7(43), GRM8(52), GRPR(7), GZMA(8), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HRH4(5), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LEP(4), LEPR(26), LHB(3), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), MCHR1(4), MCHR2(16), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPBWR1(5), NPBWR2(8), NPFFR1(2), NPY1R(17), NPY2R(20), NPY5R(22), NR3C1(8), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), P2RY1(4), P2RY10(23), P2RY11(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY4(4), P2RY6(2), P2RY8(9), PARD3(15), PRL(3), PRLHR(9), PRLR(18), PRSS1(25), PRSS3(1), PTAFR(5), PTGDR(8), PTGER2(4), PTGER3(9), PTGER4(7), PTGFR(12), PTGIR(6), PTH2R(15), RXFP1(20), RXFP2(8), SCTR(5), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SSTR5(6), TAAR1(5), TAAR2(9), TAAR5(11), TAAR6(15), TAAR8(9), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), THRA(5), THRB(4), TRHR(14), TRPV1(5), TSHB(5), TSHR(22), UTS2R(4), VIPR1(2), VIPR2(3) 175095851 2847 455 2813 1011 385 1244 586 246 378 8 0.113 1.000 1.000 105 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(11), ACVR1C(11), AKT1(3), AKT2(7), AKT3(7), ARRB1(2), ARRB2(4), ATF2(10), ATF4(2), BDNF(1), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CACNA2D1(46), CACNA2D3(24), CACNA2D4(25), CACNB1(5), CACNB2(23), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(6), CACNG3(18), CACNG4(5), CACNG5(8), CACNG6(11), CACNG7(9), CACNG8(5), CASP3(5), CD14(1), CDC25B(1), CDC42(1), CHUK(7), CRK(1), CRKL(4), DAXX(8), DDIT3(2), DUSP1(1), DUSP10(11), DUSP14(2), DUSP16(3), DUSP2(2), DUSP3(4), DUSP4(2), DUSP5(3), DUSP6(4), DUSP7(3), DUSP8(2), DUSP9(6), EGF(13), ELK1(3), ELK4(6), FAS(4), FASLG(10), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FLNA(31), FLNB(16), FLNC(55), FOS(3), GADD45A(2), GADD45B(1), GADD45G(1), GNA12(1), GNG12(3), GRB2(6), HRAS(2), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), JUN(3), JUND(1), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAPT(15), MAX(8), MEF2C(6), MKNK1(4), MKNK2(2), MOS(9), MRAS(1), MYC(4), NF1(65), NFATC2(15), NFATC4(11), NFKB1(6), NFKB2(5), NLK(3), NR4A1(5), NRAS(4), NTF3(11), NTRK1(14), NTRK2(21), PAK1(9), PAK2(3), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PPM1A(6), PPM1B(9), PPP3CB(3), PPP3CC(3), PPP3R1(5), PPP5C(2), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTPN5(12), PTPN7(1), PTPRR(16), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(24), RASA1(11), RASA2(8), RASGRF1(11), RASGRF2(22), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KA6(18), RRAS(1), RRAS2(3), SOS1(17), SOS2(13), SRF(1), STK3(4), STK4(6), STMN1(2), TAOK1(8), TAOK2(11), TAOK3(9), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TRAF2(5), TRAF6(6), ZAK(7) 222088450 2000 454 1979 647 281 754 405 198 353 9 0.286 1.000 1.000 106 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(9), ABLIM1(4), ABLIM2(4), ABLIM3(18), ARHGEF12(24), CDC42(1), CDK5(3), CFL2(3), CXCL12(3), CXCR4(6), DCC(41), DPYSL2(3), DPYSL5(10), EFNA2(1), EFNA3(2), EFNB1(2), EFNB2(4), EFNB3(1), EPHA1(9), EPHA2(10), EPHA3(56), EPHA4(18), EPHA5(78), EPHA8(21), EPHB1(44), EPHB2(10), EPHB3(14), EPHB4(10), EPHB6(53), FES(1), FYN(8), GNAI1(10), GNAI3(2), GSK3B(4), HRAS(2), ITGB1(6), L1CAM(42), LIMK1(3), LIMK2(3), LRRC4C(53), MAPK1(2), MAPK3(3), MET(22), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NGEF(12), NRAS(4), NRP1(9), NTN1(1), NTN4(6), NTNG1(33), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLXNA1(16), PLXNA2(30), PLXNA3(20), PLXNB1(12), PLXNB2(21), PLXNB3(15), PLXNC1(11), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTK2(6), RAC2(2), RASA1(11), RGS3(11), RHOA(4), RHOD(2), ROBO1(31), ROBO2(54), ROBO3(19), ROCK1(19), ROCK2(9), SEMA3A(26), SEMA3C(15), SEMA3D(33), SEMA3E(15), SEMA3F(7), SEMA3G(6), SEMA4A(5), SEMA4C(7), SEMA4D(8), SEMA4F(12), SEMA4G(3), SEMA5A(59), SEMA5B(30), SEMA6A(20), SEMA6B(12), SEMA6C(10), SEMA6D(40), SEMA7A(9), SLIT1(21), SLIT2(61), SLIT3(41), SRGAP1(20), SRGAP2(7), SRGAP3(24), UNC5A(18), UNC5B(19), UNC5C(22), UNC5D(45) 152345381 1734 439 1699 536 251 705 314 152 306 6 0.0207 1.000 1.000 107 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(4), ACTN1(7), ACTN2(43), ACTN4(6), APC(33), APC2(8), ARAF(5), ARHGEF1(5), ARHGEF12(24), ARHGEF4(11), ARHGEF6(21), ARHGEF7(6), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), ARPC5(1), BAIAP2(3), BCAR1(3), BDKRB1(1), BDKRB2(3), CD14(1), CDC42(1), CFL2(3), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CRK(1), CRKL(4), CSK(2), CYFIP1(12), CYFIP2(11), DIAPH1(3), DIAPH2(18), DIAPH3(16), DOCK1(15), EGF(13), EZR(3), F2(9), F2R(10), FGD1(13), FGD3(8), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FN1(25), GIT1(3), GNA12(1), GNA13(6), GNG12(3), GSN(4), HRAS(2), IQGAP1(8), IQGAP2(31), IQGAP3(16), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LIMK1(3), LIMK2(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(9), MRAS(1), MSN(8), MYH10(14), MYH14(9), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), NCKAP1(11), NCKAP1L(24), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PFN1(1), PFN2(1), PFN4(2), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R12B(15), PTK2(6), PXN(1), RAC2(2), RAF1(6), RDX(2), RHOA(4), ROCK1(19), ROCK2(9), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(6), SOS1(17), SOS2(13), SSH1(9), SSH2(9), SSH3(9), TIAM1(59), TIAM2(22), VAV1(8), VAV2(8), VAV3(32), VCL(8), WAS(8), WASF1(10), WASF2(3), WASL(7) 215419490 1857 439 1828 580 237 722 396 165 331 6 0.200 1.000 1.000 108 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(10), ACTG1(6), CHAD(1), COL11A2(21), COL17A1(16), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), DES(4), DSC1(16), DSC2(24), DSC3(21), DSG1(29), DSG2(12), DSG3(37), DSG4(28), FN1(25), GJA1(11), GJA10(15), GJA3(3), GJA4(6), GJA5(7), GJA8(18), GJA9(12), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GJB7(6), GJC1(8), GJC2(5), GJC3(4), GJD2(6), GJD4(3), IBSP(9), INA(4), ITGA6(12), ITGB4(10), KRT1(11), KRT10(6), KRT12(8), KRT13(5), KRT14(11), KRT15(4), KRT16(8), KRT17(9), KRT19(6), KRT2(11), KRT20(5), KRT23(7), KRT24(9), KRT25(11), KRT27(3), KRT28(11), KRT3(9), KRT31(14), KRT32(3), KRT33A(7), KRT33B(7), KRT34(15), KRT35(11), KRT36(9), KRT37(14), KRT38(15), KRT39(5), KRT4(9), KRT40(7), KRT5(14), KRT6A(14), KRT6B(19), KRT6C(5), KRT7(9), KRT71(12), KRT72(14), KRT73(10), KRT74(11), KRT75(11), KRT76(4), KRT77(6), KRT78(6), KRT79(12), KRT8(3), KRT81(2), KRT82(12), KRT83(9), KRT84(5), KRT85(5), KRT86(1), KRT9(5), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), LMNA(2), LMNB1(5), LMNB2(5), NES(33), PRPH(1), RELN(104), SPP1(5), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNXB(32), VIM(5), VTN(4), VWF(32) 193998247 2265 437 2245 741 303 987 422 154 391 8 0.433 1.000 1.000 109 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), ANXA6(8), ARRB1(2), ARRB2(4), ATP1A4(19), ATP1B1(6), ATP1B2(1), ATP1B3(2), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1S(23), CACNB1(5), CACNB3(1), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CASQ1(6), CASQ2(5), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), FXYD2(1), GJA1(11), GJA4(6), GJA5(7), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GNA11(4), GNAI3(2), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), ITPR1(20), ITPR2(40), ITPR3(21), KCNB1(28), KCNJ3(36), KCNJ5(10), MIB1(12), NME7(4), PEA15(1), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLN(1), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SLC8A3(28), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4) 149525202 2038 429 2008 677 298 851 420 177 276 16 0.0825 1.000 1.000 110 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 83 AGRN(16), CD36(4), CD44(7), CD47(6), CHAD(1), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), DAG1(3), FN1(25), FNDC1(33), FNDC3A(9), FNDC4(1), FNDC5(1), GP5(8), GP6(6), HMMR(6), HSPG2(33), IBSP(9), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), RELN(104), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SPP1(5), SV2A(17), SV2B(14), SV2C(20), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNXB(32), VTN(4), VWF(32) 173606026 1909 423 1896 582 234 850 363 115 338 9 0.140 1.000 1.000 111 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), AMOTL1(11), ASH1L(33), CASK(8), CDC42(1), CDK4(3), CGN(12), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTTN(6), EPB41(2), EPB41L1(10), EPB41L2(16), EPB41L3(31), EXOC3(3), EXOC4(16), F11R(3), GNAI1(10), GNAI3(2), HCLS1(17), HRAS(2), IGSF5(6), INADL(20), JAM2(9), JAM3(4), LLGL1(6), LLGL2(9), MAGI1(21), MAGI2(33), MAGI3(10), MLLT4(12), MPDZ(20), MPP5(2), MRAS(1), MYH1(70), MYH10(14), MYH11(29), MYH13(47), MYH14(9), MYH15(31), MYH2(77), MYH3(37), MYH4(53), MYH6(42), MYH7(59), MYH7B(10), MYH8(73), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NRAS(4), OCLN(1), PARD3(15), PARD6A(1), PARD6B(4), PARD6G(2), PPM1J(2), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP2R3A(2), PPP2R3B(6), PPP2R4(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PTEN(11), RAB13(1), RAB3B(1), RHOA(4), RRAS(1), RRAS2(3), SPTAN1(21), SRC(2), SYMPK(16), TJAP1(4), TJP1(15), TJP2(6), TJP3(6), VAPA(2), YES1(3), ZAK(7) 153848798 1441 412 1426 431 194 567 308 125 243 4 0.0764 1.000 1.000 112 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(9), ACTA2(1), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADM(1), ARRB1(2), ARRB2(4), ATF1(1), ATF2(10), ATF4(2), ATF5(2), ATP2A2(12), ATP2A3(7), CACNB3(1), CALCA(7), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CNN1(5), CORIN(25), CRH(3), CRHR1(7), DGKZ(5), ETS2(6), FOS(3), GABPA(6), GABPB2(1), GBA2(5), GJA1(11), GNAQ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), GUCA2B(2), GUCY1A3(16), IGFBP1(6), IGFBP2(4), IGFBP3(4), IGFBP4(1), IGFBP6(1), IL1B(1), IL6(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), MIB1(12), MYL2(8), MYL4(2), MYLK2(9), NFKB1(6), NOS1(29), NOS3(12), OXT(2), OXTR(4), PDE4B(14), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLCD1(4), PLCG1(7), PLCG2(18), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RAMP1(1), RAMP2(4), RAMP3(3), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SP1(6), TNXB(32), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4) 137951115 1616 405 1594 543 222 668 336 146 231 13 0.348 1.000 1.000 113 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 245 ACVR1(7), ACVR1B(11), ACVR2A(5), ACVR2B(4), AMHR2(6), BMP2(1), BMP7(12), BMPR1A(4), BMPR1B(7), BMPR2(10), CCL1(4), CCL11(2), CCL13(3), CCL14(3), CCL15(5), CCL16(4), CCL17(3), CCL18(2), CCL19(1), CCL2(2), CCL20(3), CCL21(2), CCL22(1), CCL23(3), CCL24(1), CCL25(2), CCL28(6), CCL4(2), CCL7(5), CCL8(1), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CD27(1), CD40(3), CD40LG(9), CD70(1), CNTF(6), CNTFR(5), CRLF2(9), CSF1(1), CSF1R(18), CSF2RA(8), CSF2RB(14), CSF3R(6), CX3CL1(5), CX3CR1(11), CXCL1(1), CXCL10(1), CXCL11(1), CXCL12(3), CXCL14(1), CXCL2(1), CXCL6(3), CXCL9(4), CXCR3(3), CXCR4(6), CXCR6(2), EDA(4), EDA2R(9), EDAR(8), EGF(13), EPO(6), EPOR(2), FAS(4), FASLG(10), FLT1(31), FLT3(24), FLT3LG(2), FLT4(20), GDF5(12), GH1(7), GH2(7), GHR(19), HGF(54), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL15(6), IL15RA(2), IL17A(12), IL17B(2), IL17RA(4), IL18R1(12), IL18RAP(22), IL19(2), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL1RAP(4), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL25(2), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), INHBB(4), INHBC(4), INHBE(5), KDR(56), KIT(12), KITLG(6), LEP(4), LEPR(26), LIF(3), LIFR(14), LTA(3), LTB(4), LTBR(1), MET(22), MPL(5), NGFR(5), OSM(5), OSMR(7), PDGFB(2), PDGFC(3), PDGFRA(41), PDGFRB(18), PF4(1), PF4V1(2), PLEKHO2(3), PPBP(2), PRL(3), PRLR(18), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(9), TNFRSF11B(3), TNFRSF12A(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF14(1), TNFRSF18(2), TNFRSF19(5), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(11), TNFRSF9(7), TNFSF10(3), TNFSF11(5), TNFSF12(1), TNFSF13B(1), TNFSF14(2), TNFSF15(3), TNFSF18(5), TNFSF4(2), TNFSF8(1), TNFSF9(3), TPO(33), VEGFA(1), VEGFB(2), VEGFC(21), XCL1(7), XCL2(5), XCR1(6) 138869143 1368 400 1351 413 140 572 272 148 234 2 0.108 1.000 1.000 114 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(6), CADM1(7), CADM3(15), CD2(6), CD22(16), CD226(14), CD274(3), CD276(2), CD28(4), CD34(13), CD4(8), CD40(3), CD40LG(9), CD58(1), CD6(13), CD80(3), CD86(11), CD8A(4), CD8B(5), CD99(3), CDH1(6), CDH15(9), CDH2(35), CDH3(7), CDH4(23), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CNTN1(36), CNTN2(18), CNTNAP1(11), CNTNAP2(88), CTLA4(3), ESAM(2), F11R(3), GLG1(17), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(5), ICOSLG(3), ITGA4(38), ITGA6(12), ITGA8(59), ITGA9(6), ITGAL(26), ITGAM(24), ITGAV(14), ITGB1(6), ITGB2(8), ITGB7(2), ITGB8(15), JAM2(9), JAM3(4), L1CAM(42), MADCAM1(2), MAG(7), MPZ(2), MPZL1(3), NCAM1(30), NCAM2(28), NEGR1(14), NEO1(12), NFASC(46), NLGN1(34), NLGN2(10), NLGN3(14), NRCAM(35), NRXN2(25), NRXN3(49), OCLN(1), PDCD1(4), PDCD1LG2(4), PTPRC(41), PTPRF(15), PTPRM(14), PVRL1(16), PVRL3(7), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SELL(9), SELP(29), SELPLG(2), SIGLEC1(18), SPN(4), VCAM1(28), VCAN(104) 115140551 1425 388 1411 439 177 629 281 114 218 6 0.0486 1.000 1.000 115 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCRL2(2), CHML(12), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CX3CR1(11), CXCR3(3), CXCR4(6), DRD1(13), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GPR17(8), GPR173(4), GPR174(18), GPR27(5), GPR35(8), GPR37(17), GPR4(7), GPR50(21), GPR6(8), GPR63(10), GPR83(12), GPR85(16), GPR87(4), GRPR(7), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC3R(16), MC4R(3), MC5R(22), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPN1SW(8), OPN3(3), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OR10A5(14), OR11A1(8), OR12D3(4), OR1C1(29), OR1F1(3), OR1Q1(11), OR2H1(16), OR5V1(6), OR7A5(6), OR7C1(5), OR8B8(12), OXTR(4), P2RY1(4), P2RY10(23), P2RY11(2), P2RY12(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY6(2), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), RGR(4), RHO(7), RRH(2), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SUCNR1(1), TBXA2R(1), TRHR(14) 96041042 1376 384 1356 497 214 580 302 131 146 3 0.0443 1.000 1.000 116 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(33), APC2(8), AXIN1(7), AXIN2(5), BTRC(12), CACYBP(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CCND1(3), CCND2(4), CCND3(1), CER1(7), CHD8(29), CREBBP(30), CSNK1A1(2), CSNK1A1L(14), CSNK1E(6), CSNK2A1(5), CSNK2A2(2), CTBP1(2), CUL1(14), CXXC4(2), DAAM1(8), DAAM2(4), DKK1(3), DKK2(14), DKK4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), FBXW11(2), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LEF1(12), LRP5(17), LRP6(16), MAP3K7(10), MAPK10(6), MAPK8(2), MAPK9(8), MMP7(7), MYC(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKD1(6), NKD2(8), NLK(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PORCN(7), PPARD(6), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRICKLE1(11), PRICKLE2(9), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PSEN1(6), RAC2(2), RHOA(4), ROCK1(19), ROCK2(9), RUVBL1(4), SENP2(6), SFRP1(2), SFRP2(6), SFRP4(7), SFRP5(1), SIAH1(1), SKP1(4), SMAD2(7), SMAD3(6), SMAD4(21), SOX17(1), TBL1X(5), TBL1XR1(6), TBL1Y(1), TCF7(3), TCF7L1(6), TCF7L2(7), VANGL1(9), VANGL2(15), WIF1(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6) 126116160 1051 375 1041 313 178 387 203 97 184 2 0.0864 1.000 1.000 117 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADK(2), ADSL(2), ADSS(6), ADSSL1(4), AK2(4), AK5(14), AK7(13), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), FHIT(2), GART(9), GDA(11), GMPR(5), GMPR2(1), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NME6(3), NME7(4), NPR1(16), NPR2(6), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(5), PAPSS2(10), PDE10A(31), PDE11A(24), PDE1A(17), PDE1C(28), PDE2A(11), PDE3B(16), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6G(3), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PDE9A(7), PFAS(9), PKLR(16), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PPAT(1), PRIM1(3), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), XDH(18), ZNRD1(1) 130309123 1063 370 1057 346 121 398 248 112 182 2 0.617 1.000 1.000 118 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRB1(1), CSNK1D(7), DRD1(13), EGF(13), GJA1(11), GJD2(6), GNA11(4), GNAI1(10), GNAI3(2), GNAQ(5), GNAS(29), GRB2(6), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), HTR2A(6), HTR2B(5), HTR2C(8), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAP2K2(1), MAP2K5(4), MAP3K2(6), MAPK1(2), MAPK3(3), MAPK7(7), NPR1(16), NPR2(6), NRAS(4), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), PRKX(3), RAF1(6), SOS1(17), SOS2(13), SRC(2), TJP1(15), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17) 102719217 1089 369 1074 353 149 424 234 105 174 3 0.292 1.000 1.000 119 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(9), ACTA2(1), ACTN2(43), ACTN4(6), DES(4), DMD(108), MYBPC1(21), MYBPC2(8), MYBPC3(15), MYH3(37), MYH6(42), MYH7(59), MYH8(73), MYL1(4), MYL2(8), MYL3(4), MYL4(2), MYL9(3), MYOM1(16), NEB(91), TCAP(1), TMOD1(5), TNNC2(2), TNNI1(3), TNNI2(4), TNNI3(6), TNNT1(3), TNNT2(6), TNNT3(5), TPM1(1), TPM2(3), TPM3(2), TPM4(2), TTN(654), VIM(5) 110040676 1256 368 1243 364 127 537 301 128 150 13 0.571 1.000 1.000 120 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 147 AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CBL(10), CBLB(10), CBLC(1), CCND1(3), CCND2(4), CCND3(1), CISH(1), CNTF(6), CNTFR(5), CREBBP(30), CRLF2(9), CSF2RA(8), CSF2RB(14), CSF3R(6), EP300(11), EPO(6), EPOR(2), GH1(7), GH2(7), GHR(19), GRB2(6), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL13RA2(13), IL15(6), IL15RA(2), IL19(2), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), IRF9(3), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), LIF(3), LIFR(14), MPL(5), MYC(4), OSM(5), OSMR(7), PIAS1(2), PIAS2(6), PIAS3(7), PIAS4(2), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIM1(1), PRL(3), PRLR(18), PTPN11(9), PTPN6(6), SOCS2(3), SOCS4(1), SOCS5(8), SOCS7(2), SOS1(17), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), STAM(11), STAM2(5), STAT1(7), STAT2(6), STAT3(11), STAT4(11), STAT5A(3), STAT5B(8), STAT6(2), TPO(33), TYK2(5) 114260646 929 360 923 297 91 368 202 100 167 1 0.814 1.000 1.000 121 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(26), ADCY8(48), ARAF(5), ATF4(2), CACNA1C(61), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CREBBP(30), EP300(11), GNAQ(5), GRIA1(18), GRIA2(28), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18) 77212596 854 355 843 257 124 356 178 67 126 3 0.0577 1.000 1.000 122 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ATF4(2), CACNA1C(61), CACNA1D(21), CACNA1F(30), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDC42(1), CGA(2), ELK1(3), FSHB(4), GNA11(4), GNAQ(5), GNAS(29), GNRH1(1), GNRHR(5), GRB2(6), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), LHB(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK9(8), MMP14(4), MMP2(24), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLD1(19), PLD2(7), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCD(7), PRKX(3), PTK2B(14), RAF1(6), SOS1(17), SOS2(13), SRC(2) 99192449 953 355 938 318 153 362 195 81 161 1 0.450 1.000 1.000 123 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(5), CACNA1A(32), CRH(3), CRHR1(7), GNA11(4), GNA12(1), GNA13(6), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GNAZ(5), GRIA1(18), GRIA2(28), GRIA3(24), GRID2(54), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), IGF1(4), IGF1R(8), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(29), NOS3(12), NPR1(16), NPR2(6), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), RAF1(6), RYR1(111) 86640418 994 349 984 288 151 385 202 88 164 4 0.0126 1.000 1.000 124 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 127 ACACA(20), ACACB(28), AKT1(3), AKT2(7), AKT3(7), ARAF(5), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CBL(10), CBLB(10), CBLC(1), CRK(1), CRKL(4), ELK1(3), EXOC7(4), FASN(18), FBP1(2), FBP2(2), FLOT1(1), FLOT2(4), FOXO1(5), G6PC(7), G6PC2(8), GCK(6), GRB2(6), GSK3B(4), GYS1(4), GYS2(8), HRAS(2), IKBKB(9), INPP5D(11), INSR(10), IRS1(20), IRS4(34), LIPE(5), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MKNK1(4), MKNK2(2), NRAS(4), PCK1(21), PCK2(4), PDE3A(30), PDE3B(16), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PKLR(16), PPARGC1A(23), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R3A(48), PPP1R3B(1), PPP1R3C(3), PPP1R3D(5), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCI(11), PRKCZ(4), PRKX(3), PTPN1(3), PTPRF(15), PYGB(5), PYGL(6), PYGM(9), RAF1(6), RAPGEF1(7), RHEB(4), RHOQ(1), RPS6(3), RPS6KB1(3), RPS6KB2(3), SH2B2(6), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(12), SOS1(17), SOS2(13), SREBF1(3), TRIP10(2), TSC1(10), TSC2(13) 123443898 895 345 883 316 138 333 192 89 140 3 0.900 1.000 1.000 125 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(21), AMY2A(6), AMY2B(11), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHX58(4), ENPP1(14), ENPP3(19), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), G6PC(7), G6PC2(8), GAA(12), GANC(3), GBA(7), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), IFIH1(10), LYZL1(5), MGAM(51), MOV10L1(11), NUDT5(2), NUDT8(2), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SI(117), SKIV2L2(15), SMARCA2(22), SMARCA5(5), TREH(1), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), UXS1(6) 98662401 853 341 846 234 93 358 186 81 135 0 0.0748 1.000 1.000 126 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG6(1), ALG8(3), ALG9(5), B3GNT1(3), B3GNT2(4), B3GNT6(5), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), CHPF(10), CHST1(17), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST2(14), CHST3(1), CHST4(3), CHST6(7), CHST7(2), CHSY1(5), DAD1(2), DDOST(1), DPAGT1(5), EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), FUT11(5), FUT8(7), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GANAB(9), GCNT1(8), GCNT3(2), GCNT4(9), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), NDST1(6), NDST2(6), NDST3(16), NDST4(36), OGT(19), RPN1(3), RPN2(4), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST6GAL1(4), ST6GALNAC1(8), STT3B(4), UST(5), WBSCR17(33), XYLT1(44), XYLT2(3) 88486212 806 341 797 271 127 297 187 85 108 2 0.672 1.000 1.000 127 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(34), ABCA12(39), ABCA13(86), ABCA2(21), ABCA3(11), ABCA4(19), ABCA5(23), ABCA6(26), ABCA7(18), ABCA8(25), ABCA9(26), ABCB1(45), ABCB10(11), ABCB11(28), ABCB4(19), ABCB5(60), ABCB6(4), ABCB7(12), ABCB8(11), ABCB9(7), ABCC1(14), ABCC10(11), ABCC11(38), ABCC12(22), ABCC2(11), ABCC3(13), ABCC4(21), ABCC5(14), ABCC6(9), ABCC8(25), ABCC9(30), ABCD1(2), ABCD2(14), ABCD3(2), ABCD4(5), ABCG1(8), ABCG2(14), ABCG4(16), ABCG5(19), ABCG8(19), CFTR(11), TAP1(1), TAP2(8) 94274026 869 341 863 263 85 335 202 88 155 4 0.109 1.000 1.000 128 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(7), ACTN2(43), ACTN4(6), ARHGAP5(17), BCAR1(3), CD99(3), CDC42(1), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNND1(10), CXCL12(3), CXCR4(6), CYBA(1), CYBB(11), ESAM(2), EZR(3), F11R(3), GNAI1(10), GNAI3(2), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), ITK(16), JAM2(9), JAM3(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(12), MMP2(24), MMP9(10), MSN(8), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NCF1(3), NCF2(8), NCF4(3), NOX1(8), NOX3(21), OCLN(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAC2(2), RAP1A(1), RAP1B(2), RAPGEF3(7), RAPGEF4(13), RHOA(4), RHOH(6), ROCK1(19), ROCK2(9), SIPA1(2), THY1(6), TXK(7), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCAM1(28), VCL(8) 96343127 885 337 879 275 113 375 185 73 137 2 0.200 1.000 1.000 129 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ASIP(1), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), CREB3L1(4), CREB3L2(8), CREB3L3(3), CREB3L4(2), CREBBP(30), DCT(16), DVL1(5), DVL2(7), DVL3(13), EDN1(1), EDNRB(16), EP300(11), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GSK3B(4), HRAS(2), KIT(12), KITLG(6), LEF1(12), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MC1R(2), MITF(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), POMC(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), TCF7(3), TCF7L1(6), TCF7L2(7), TYR(29), TYRP1(5), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6) 85137721 880 333 866 295 165 324 188 70 131 2 0.249 1.000 1.000 130 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADK(2), ADSL(2), ADSS(6), AK2(4), AK5(14), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), ATP1B1(6), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5F1(3), ATP5G3(2), ATP5J2(3), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(11), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NPR1(16), NPR2(6), NT5E(5), NT5M(3), NUDT2(3), PAICS(1), PAPSS1(5), PAPSS2(10), PDE1A(17), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6B(15), PDE6C(12), PDE6G(3), PDE7B(6), PDE8A(3), PDE9A(7), PFAS(9), PKLR(16), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), PPAT(1), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RRM1(6), RRM2(6) 102556225 846 333 841 281 101 313 191 90 149 2 0.678 1.000 1.000 131 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(7), BCAR1(3), CAPN1(2), CAPN10(8), CAPN11(13), CAPN2(5), CAPN3(8), CAPN5(12), CAPN6(25), CAPN7(7), CAPN9(5), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CRK(1), CSK(2), DOCK1(15), FYN(8), GIT2(5), GRB2(6), ILK(1), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAPK10(6), MAPK12(2), MAPK4(9), MAPK6(4), MAPK7(7), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PDPK1(3), PIK3R2(7), PTK2(6), PXN(1), RAC2(2), RAP1B(2), RAPGEF1(7), RHO(7), ROCK1(19), ROCK2(9), SDCCAG8(12), SEPP1(1), SHC1(6), SHC3(8), SORBS1(12), SOS1(17), SRC(2), TLN1(15), TNS1(23), VASP(2), VAV2(8), VAV3(32), VCL(8), ZYX(6) 107108167 915 332 904 268 88 386 192 75 170 4 0.108 1.000 1.000 132 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACP1(4), ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), ACVR1B(11), ACVR1C(11), BAIAP2(3), CDC42(1), CDH1(6), CREBBP(30), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNND1(10), EP300(11), ERBB2(12), FARP2(7), FER(16), FGFR1(4), FYN(8), IGF1R(8), INSR(10), IQGAP1(8), LEF1(12), LMO7(22), MAP3K7(10), MAPK1(2), MAPK3(3), MET(22), MLLT4(12), NLK(3), PARD3(15), PTPN1(3), PTPN6(6), PTPRB(50), PTPRF(15), PTPRJ(12), PTPRM(14), PVRL1(16), PVRL3(7), PVRL4(9), RAC2(2), RHOA(4), SMAD2(7), SMAD3(6), SMAD4(21), SNAI1(3), SNAI2(14), SORBS1(12), SRC(2), SSX2IP(3), TCF7(3), TCF7L1(6), TCF7L2(7), TGFBR1(7), TGFBR2(7), TJP1(15), VCL(8), WAS(8), WASF1(10), WASF2(3), WASF3(13), WASL(7), YES1(3) 93102896 739 329 725 204 107 256 150 73 153 0 0.0503 1.000 1.000 133 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(24), BDKRB1(1), BDKRB2(3), C1QA(7), C1QB(11), C1QC(5), C1R(4), C1S(4), C2(10), C3(13), C3AR1(11), C4BPA(6), C4BPB(1), C5(6), C5AR1(7), C6(29), C8A(18), C8B(20), C9(20), CD46(3), CD55(3), CFB(4), CFH(46), CFI(6), CPB2(6), CR1(34), CR2(20), F10(5), F11(13), F12(4), F13A1(29), F13B(28), F2(9), F2R(10), F3(3), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), KNG1(9), MASP1(13), MASP2(8), MBL2(13), PLAT(12), PLAUR(4), PLG(32), PROC(4), PROS1(30), SERPINA1(4), SERPINA5(18), SERPINC1(5), SERPIND1(3), SERPINE1(14), SERPINF2(2), SERPING1(7), TFPI(4), THBD(4), VWF(32) 71504592 815 328 805 239 72 379 146 71 145 2 0.260 1.000 1.000 134 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(7), ACVR1B(11), ACVRL1(11), AKT1(3), AURKB(2), BMPR1A(4), BMPR2(10), BUB1(10), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(4), CLK1(3), CLK2(10), CLK4(4), COL4A3BP(2), CSNK2A1(5), CSNK2A2(2), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MAP3K10(4), MOS(9), NEK1(11), NEK3(4), OCRL(13), PAK4(6), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CB(8), PIK3CG(33), PIM2(7), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18), PLK3(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKG1(20), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KB1(3), TGFBR1(7), VRK1(6) 88089357 735 328 728 204 107 279 152 73 120 4 0.0797 1.000 1.000 135 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(9), ACTN1(7), ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGEF6(21), ARHGEF7(6), BCAR1(3), CAV1(1), CDC42(1), CRK(1), CSE1L(7), DOCK1(15), EPHB2(10), FYN(8), GRB2(6), GRB7(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), MAP2K4(8), MAP2K7(7), MAP3K11(5), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MRAS(1), MYLK(26), MYLK2(9), P4HB(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CB(8), PKLR(16), PLCG1(7), PLCG2(18), PTEN(11), PTK2(6), RAF1(6), RALA(5), RHO(7), ROCK1(19), ROCK2(9), SHC1(6), SOS1(17), SOS2(13), SRC(2), TLN1(15), TLN2(30), VASP(2), WAS(8), ZYX(6) 94485927 722 327 708 224 94 275 145 60 147 1 0.401 1.000 1.000 136 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(9), ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), ATM(53), ATR(26), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(10), CDC14B(3), CDC16(2), CDC20(8), CDC23(3), CDC25A(4), CDC25B(1), CDC25C(8), CDC27(7), CDC6(4), CDC7(6), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), CHEK1(7), CHEK2(10), CREBBP(30), CUL1(14), DBF4(6), E2F1(3), E2F2(5), E2F3(2), EP300(11), ESPL1(6), FZR1(3), GADD45A(2), GADD45B(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(8), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), PCNA(1), PKMYT1(3), PLK1(9), PRKDC(50), PTTG1(2), RBL1(7), RBL2(5), SFN(1), SKP1(4), SKP2(3), SMAD2(7), SMAD3(6), SMAD4(21), SMC1A(9), SMC1B(8), TFDP1(10), TGFB1(3), TGFB2(10), WEE1(4), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 106514915 667 325 663 147 91 208 140 83 142 3 0.000425 1.000 1.000 137 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(3), CALM2(1), CALML3(3), CALML6(1), CDIPT(1), CDS1(3), CDS2(4), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5D(11), INPP5E(2), INPPL1(11), ITPK1(1), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), OCRL(13), PI4KA(17), PI4KB(10), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3C3(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PRKCA(10), PRKCG(20), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9) 97716098 786 323 780 228 102 291 176 69 144 4 0.117 1.000 1.000 138 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(5), BID(2), CASP3(5), CD244(14), CD247(1), CD48(5), FAS(4), FASLG(10), FCER1G(2), FCGR3A(9), FYN(8), GRB2(6), GZMB(6), HCST(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-E(2), HLA-G(5), HRAS(2), ICAM1(2), ICAM2(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), ITGAL(26), ITGB2(8), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KLRC1(5), KLRC2(2), KLRC3(5), KLRD1(2), KLRK1(4), LAT(4), LCK(9), LCP2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(9), NCR2(3), NCR3(1), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NRAS(4), PAK1(9), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRF1(8), PRKCA(10), PRKCG(20), PTK2B(14), PTPN11(9), PTPN6(6), RAC2(2), RAF1(6), SH2D1A(3), SH2D1B(3), SH3BP2(10), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SYK(5), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TYROBP(2), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(8), VAV2(8), VAV3(32), ZAP70(9) 86279270 759 323 745 231 107 293 161 71 124 3 0.193 1.000 1.000 139 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), AKAP1(14), AKAP10(4), AKAP11(14), AKAP12(9), AKAP2(11), AKAP3(15), AKAP4(17), AKAP5(2), AKAP6(45), AKAP7(1), AKAP8(5), AKAP9(32), ARHGEF1(5), CALM1(3), CALM2(1), CHMP1B(1), GNA11(4), GNA12(1), GNA13(6), GNA14(2), GNA15(1), GNAI3(2), GNAL(5), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB5(7), GNG12(3), GNG13(5), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GNGT2(3), HRAS(2), IL18BP(1), ITPR1(20), KCNJ3(36), NRAS(4), PALM2(7), PDE1A(17), PDE1B(13), PDE1C(28), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PLCB3(9), PPP3CC(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(6), USP5(8) 92682314 811 322 804 275 108 319 188 71 119 6 0.713 1.000 1.000 140 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(3), AKT2(7), AKT3(7), BCL10(4), CARD11(34), CBL(10), CBLB(10), CBLC(1), CD247(1), CD28(4), CD3D(2), CD3E(2), CD4(8), CD40LG(9), CD8A(4), CD8B(5), CDC42(1), CDK4(3), CHUK(7), CTLA4(3), FOS(3), FYN(8), GRAP2(13), GRB2(6), HRAS(2), ICOS(5), IFNG(7), IKBKB(9), IL10(2), IL2(7), IL4(1), IL5(2), ITK(16), JUN(3), LAT(4), LCK(9), LCP2(10), MALT1(13), MAP3K8(4), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDCD1(4), PDK1(6), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCQ(12), PTPN6(6), PTPRC(41), RASGRP1(3), RHOA(4), SOS1(17), SOS2(13), TEC(12), TNF(2), VAV1(8), VAV2(8), VAV3(32), ZAP70(9) 78283744 693 321 680 200 107 269 130 55 130 2 0.121 1.000 1.000 141 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(10), CD14(1), CD19(5), CD1B(17), CD1C(15), CD1D(10), CD1E(27), CD2(6), CD22(16), CD33(13), CD34(13), CD36(4), CD37(2), CD38(4), CD3D(2), CD3E(2), CD4(8), CD44(7), CD5(7), CD55(3), CD8A(4), CD8B(5), CD9(3), CR1(34), CR2(20), CSF1(1), CSF1R(18), CSF2RA(8), CSF3R(6), DNTT(6), EPO(6), EPOR(2), FCER2(2), FCGR1A(5), FLT3(24), FLT3LG(2), GP5(8), HLA-DRA(3), HLA-DRB1(5), IL11RA(1), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL2RA(6), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL7(2), IL7R(21), IL9R(16), ITGA1(14), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGAM(24), ITGB3(13), KIT(12), KITLG(6), MME(20), MS4A1(11), TFRC(6), THPO(7), TNF(2), TPO(33) 65178047 690 306 678 230 63 288 130 69 140 0 0.807 1.000 1.000 142 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(9), ATM(53), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(8), CDC14A(10), CDC14B(3), CDC20(8), CDC25A(4), CDC25B(1), CDC25C(8), CDC6(4), CDC7(6), CDH1(6), CDK2(1), CDK4(3), CDKN1A(2), CHEK1(7), CHEK2(10), DTX4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), EP300(11), ESPL1(6), GADD45A(2), GSK3B(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), HDAC8(1), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MPEG1(12), MPL(5), PCNA(1), PLK1(9), PRKDC(50), PTPRA(11), PTTG1(2), RBL1(7), SKP2(3), SMAD4(21), TBC1D8(9), TFDP1(10), TGFB1(3), WEE1(4) 85862341 553 299 549 124 67 181 107 66 129 3 0.000945 1.000 1.000 143 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(10), BCL2(5), CABIN1(10), CALM1(3), CALM2(1), CAMK2B(16), CAMK4(16), CD3E(2), CD69(2), CDKN1A(2), CNR1(15), CREBBP(30), CSNK2A1(5), CTLA4(3), EGR2(4), EGR3(1), EP300(11), FCER1A(9), FCGR3A(9), FOS(3), FOSL1(4), GATA3(12), GATA4(7), GSK3A(1), GSK3B(4), HRAS(2), ICOS(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL13(2), IL1B(1), IL2(7), IL2RA(6), IL3(4), IL4(1), IL6(2), ITK(16), JUNB(1), KPNA5(4), MAP2K7(7), MAPK14(4), MAPK8(2), MAPK9(8), MEF2A(2), MEF2B(2), MEF2D(4), MYF5(12), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB2(5), NFKBIB(3), NFKBIE(2), NPPB(3), NUP214(26), OPRD1(2), P2RX7(6), PAK1(9), PIN1(1), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPRC(41), RELA(3), RPL13A(2), SFN(1), SLA(6), SP1(6), SP3(6), TGFB1(3), TNF(2), TRAF2(5), TRPV6(25), VAV1(8), VAV2(8), VAV3(32), XPO5(6) 72801598 586 297 581 183 67 223 121 48 125 2 0.434 1.000 1.000 144 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(4), ALG6(1), CCKBR(24), CCR2(6), CCR3(4), CCR5(4), CELSR1(17), CELSR2(22), CELSR3(36), CHRM2(39), CHRM3(27), CIDEB(2), CXCR3(3), DRD4(2), EDNRA(3), EMR2(13), EMR3(10), F2R(10), FSHR(37), GHRHR(5), GNRHR(5), GPR116(11), GPR132(6), GPR133(18), GPR135(4), GPR143(2), GPR17(8), GPR18(4), GPR55(9), GPR56(6), GPR61(8), GPR84(4), GRM1(48), GRPR(7), HRH4(5), LGR6(22), LPHN2(47), LPHN3(78), NTSR1(10), OR2M4(33), P2RY11(2), P2RY13(1), PTGFR(12), SMO(17), SSTR2(4), TAAR5(11), TSHR(22), VN1R1(2) 52700176 675 297 669 208 99 272 140 67 95 2 0.0223 1.000 1.000 145 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 87 ACVR1(7), ACVR1B(11), ACVR1C(11), ACVR2A(5), ACVR2B(4), ACVRL1(11), AMHR2(6), BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BMPR1A(4), BMPR1B(7), BMPR2(10), CHRD(13), COMP(4), CREBBP(30), CUL1(14), DCN(5), E2F4(5), E2F5(1), EP300(11), FST(5), GDF5(12), GDF6(10), GDF7(5), ID1(1), ID2(4), ID3(3), IFNG(7), INHBB(4), INHBC(4), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(61), MAPK1(2), MAPK3(3), MYC(4), NODAL(2), NOG(1), PITX2(8), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), RBL1(7), RBL2(5), RHOA(4), ROCK1(19), ROCK2(9), RPS6KB1(3), RPS6KB2(3), SKP1(4), SMAD1(7), SMAD2(7), SMAD3(6), SMAD4(21), SMAD5(1), SMAD6(2), SMAD9(4), SMURF1(8), SMURF2(4), SP1(6), TFDP1(10), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNF(2), ZFYVE16(7), ZFYVE9(14) 78651197 626 296 623 174 101 219 134 63 108 1 0.0837 1.000 1.000 146 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(3), AKT2(7), AKT3(7), CASP8(6), CCL4(2), CD14(1), CD40(3), CD80(3), CD86(11), CHUK(7), CXCL10(1), CXCL11(1), CXCL9(4), FADD(2), FOS(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IKBKB(9), IKBKE(9), IL12A(2), IL12B(3), IL1B(1), IL6(2), IRAK1(6), IRAK4(4), IRF5(1), IRF7(3), JUN(3), LBP(8), LY96(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K7(10), MAP3K8(4), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), RELA(3), RIPK1(11), SPP1(5), STAT1(7), TBK1(4), TICAM1(3), TLR1(9), TLR2(10), TLR3(4), TLR4(64), TLR5(8), TLR6(11), TLR7(17), TLR8(16), TLR9(9), TNF(2), TOLLIP(2), TRAF3(4), TRAF6(6) 69663644 564 295 560 186 54 219 124 68 99 0 0.701 1.000 1.000 147 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(9), AKT1(3), BDKRB2(3), CALM1(3), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(16), FLT1(31), FLT4(20), KDR(56), NOS3(12), PDE2A(11), PDE3A(30), PDE3B(16), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKG1(20), PRKG2(15), RYR2(359), SLC7A1(5), SYT1(6), TNNI1(3) 32393146 649 288 629 183 62 297 127 63 91 9 0.0364 1.000 1.000 148 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(9), ABL2(18), AKT1(3), AKT2(7), AKT3(7), ARAF(5), AREG(1), BTC(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CBL(10), CBLB(10), CBLC(1), CDKN1A(2), CDKN1B(5), CRK(1), CRKL(4), EGF(13), ELK1(3), ERBB2(12), ERBB3(11), ERBB4(51), EREG(4), GAB1(7), GRB2(6), GSK3B(4), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MYC(4), NCK1(5), NCK2(6), NRAS(4), NRG1(18), NRG2(3), NRG4(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SRC(2), STAT5A(3), STAT5B(8), TGFA(1) 75744627 609 282 587 194 95 226 117 59 111 1 0.536 1.000 1.000 149 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CDC42(1), CDK2(1), CDKN1B(5), CREB1(2), CREB5(18), EBP(3), ERBB4(51), F2RL2(12), GAB1(7), GADD45A(2), GRB2(6), GSK3A(1), GSK3B(4), IFI27(1), IGF1(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), MET(22), MYC(4), NOLC1(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARD3(15), PARD6A(1), PDK1(6), PIK3CD(4), PPP1R13B(7), PREX1(40), PTEN(11), PTK2(6), PTPN1(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SLC2A4(4), SOS1(17), SOS2(13), TSC1(10), TSC2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 58977303 505 273 495 128 69 207 96 34 99 0 0.00927 1.000 1.000 150 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(9), AGTR2(6), ATP8A1(7), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(6), CXCR6(2), EDNRA(3), EDNRB(16), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GNRHR(5), GRPR(7), LHCGR(14), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), NMBR(8), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), TAC4(1), TACR1(4), TACR2(2), TACR3(15), TRHR(14), TSHR(22) 42039386 562 266 554 217 89 233 122 53 64 1 0.475 1.000 1.000 151 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(3), AKT2(7), AKT3(7), BCL10(4), BLNK(2), BTK(25), CARD11(34), CD19(5), CD22(16), CD72(2), CD79A(2), CD79B(2), CD81(1), CHUK(7), CR2(20), FCGR2B(7), FOS(3), GSK3B(4), HRAS(2), IFITM1(2), IKBKB(9), INPP5D(11), JUN(3), LILRB3(7), LYN(6), MALT1(13), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPN6(6), RAC2(2), RASGRP3(11), SYK(5), VAV1(8), VAV2(8), VAV3(32) 56529664 470 265 464 154 60 181 108 39 81 1 0.546 1.000 1.000 152 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(28), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ADIPOR1(6), ADIPOR2(3), AKT1(3), AKT2(7), AKT3(7), CAMKK1(4), CAMKK2(3), CD36(4), CHUK(7), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), G6PC(7), G6PC2(8), IKBKB(9), IRS1(20), IRS4(34), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), MAPK10(6), MAPK8(2), MAPK9(8), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NPY(4), PCK1(21), PCK2(4), POMC(4), PPARA(4), PPARGC1A(23), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKCQ(12), PTPN11(9), RELA(3), RXRA(1), RXRB(3), RXRG(18), SLC2A1(1), SLC2A4(4), STAT3(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5), TYK2(5) 65365026 502 265 499 179 65 186 100 57 94 0 0.881 1.000 1.000 153 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(33), ASH2L(2), CARM1(4), CTCFL(21), DOT1L(14), EED(8), EHMT1(15), EHMT2(9), EZH1(4), EZH2(11), FBXO11(5), HCFC1(24), HSF4(1), JMJD4(3), JMJD6(3), KDM6A(12), MEN1(6), NSD1(23), OGT(19), PAXIP1(7), PPP1CA(2), PPP1CB(4), PPP1CC(1), PRDM2(21), PRDM7(6), PRDM9(82), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), RBBP5(3), SATB1(10), SETD1A(18), SETD7(2), SETD8(1), SETDB1(11), SETDB2(13), SETMAR(5), SMYD3(10), STK38(3), SUV39H1(1), SUV39H2(4), SUV420H1(16), WHSC1(12), WHSC1L1(8) 91640318 488 261 482 146 54 197 117 42 75 3 0.657 1.000 1.000 154 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(10), CHUK(7), CREB1(2), DAXX(8), ELK1(3), FOS(3), GRB2(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP3K9(17), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK4(9), MAPK6(4), MAPK7(7), MAPK8(2), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MKNK2(2), MYC(4), NFKB1(6), NFKBIA(4), PAK1(9), PAK2(3), RAF1(6), RELA(3), RIPK1(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KB1(3), RPS6KB2(3), SHC1(6), SP1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5) 74693043 481 258 475 136 55 170 95 44 117 0 0.262 1.000 1.000 155 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5E(2), INPPL1(11), IPMK(11), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(7), MINPP1(3), MIOX(2), OCRL(13), PI4KA(17), PI4KB(10), PIK3C3(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9) 57481010 447 256 443 134 55 168 106 38 78 2 0.256 1.000 1.000 156 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(21), AMY2A(6), AMY2B(11), ENPP1(14), ENPP3(19), G6PC(7), GAA(12), GANAB(9), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), MGAM(51), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RNPC3(1), SI(117), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UXS1(6) 45835022 499 251 495 132 58 224 102 42 73 0 0.0372 1.000 1.000 157 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 90 CD2BP2(5), CDC40(4), CLK2(10), CLK3(2), CLK4(4), COL2A1(24), CPSF1(14), CPSF2(8), CPSF3(6), CSTF1(7), CSTF2(3), CSTF2T(7), CSTF3(7), DDIT3(2), DDX1(9), DDX20(4), DHX15(7), DHX16(7), DHX38(9), DHX8(14), DHX9(12), DICER1(15), DNAJC8(4), FUS(5), GIPC1(6), LSM2(1), LSM7(2), METTL3(3), NCBP1(3), NCBP2(3), NONO(6), NXF1(11), PABPN1(5), PAPOLA(11), POLR2A(11), PPM1G(6), PRPF18(3), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(10), PSKH1(3), PTBP1(4), PTBP2(9), RBM17(4), RBM5(6), RNGTT(10), RNMT(8), RNPS1(1), SF3A1(10), SF3A2(1), SF3A3(2), SF3B1(15), SF3B2(14), SF3B4(8), SF3B5(3), SNRPA(1), SNRPA1(1), SNRPB(3), SNRPB2(1), SNRPD1(2), SNRPE(1), SNRPG(2), SNRPN(15), SNURF(2), SPOP(4), SRPK1(5), SRPK2(6), SRRM1(4), SUPT5H(9), U2AF2(6), XRN2(8) 84401454 457 249 453 126 70 148 98 53 88 0 0.330 1.000 1.000 158 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(3), AKT2(7), AKT3(7), BTK(25), FCER1A(9), FCER1G(2), FYN(8), GAB2(7), GRB2(6), HRAS(2), IL13(2), IL3(4), IL4(1), IL5(2), INPP5D(11), LAT(4), LCP2(10), LYN(6), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MS4A2(7), NRAS(4), PDK1(6), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PRKCA(10), PRKCD(7), PRKCE(5), RAC2(2), RAF1(6), SOS1(17), SOS2(13), SYK(5), TNF(2), VAV1(8), VAV2(8), VAV3(32) 55364096 473 247 464 145 61 176 110 37 87 2 0.353 1.000 1.000 159 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(3), AKT2(7), AKT3(7), CASP9(6), CDC42(1), HRAS(2), KDR(56), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPKAPK2(2), MAPKAPK3(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NOS3(12), NRAS(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCA(10), PRKCG(20), PTGS2(12), PTK2(6), PXN(1), RAC2(2), RAF1(6), SH2D2A(10), SHC2(5), SPHK2(4), SRC(2), VEGFA(1) 54113477 432 246 422 156 60 175 96 48 52 1 0.793 1.000 1.000 160 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGAP1(5), ARHGAP4(14), ARHGEF11(24), BTK(25), CDC42(1), CFL2(3), GDI1(6), GDI2(1), INPPL1(11), ITPR1(20), ITPR2(40), ITPR3(21), LIMK1(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDK1(6), PIK3CD(4), PIK3CG(33), PIK3R1(4), PITX2(8), PPP1R13B(7), PTEN(11), RACGAP1(7), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), SAG(5), WASF1(10), WASL(7) 54553546 449 246 442 125 71 163 88 34 93 0 0.0649 1.000 1.000 161 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BTRC(12), CSNK1A1(2), CSNK1A1L(14), CSNK1D(7), CSNK1E(6), CSNK1G1(4), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(2), GLI1(17), GLI2(28), GLI3(39), GSK3B(4), HHIP(4), IHH(3), LRP2(88), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), PTCH1(16), PTCH2(8), RAB23(1), SHH(2), SMO(17), STK36(12), SUFU(2), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6), ZIC2(3) 48461340 475 245 468 135 96 190 101 33 55 0 0.0389 1.000 1.000 162 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(3), CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), ITPA(1), NME6(3), NME7(4), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PRIM1(3), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), TK1(1), TK2(1), TXNRD1(7), TXNRD2(2), TYMS(3), UCK2(10), UMPS(4), UPB1(2), UPP1(6), UPP2(6), UPRT(5), ZNRD1(1) 64305375 416 244 415 121 51 160 99 38 66 2 0.301 1.000 1.000 163 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(16), AKT1(3), AKT2(7), AKT3(7), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CAPN1(2), CAPN2(5), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(14), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL3(4), IL3RA(8), IRAK1(6), IRAK2(6), IRAK3(6), IRAK4(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), NTRK1(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TRADD(2), TRAF2(5) 63540108 432 244 428 146 51 155 98 53 71 4 0.849 1.000 1.000 164 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ADCY4(12), ADCY6(10), ADCY8(48), CACNA1A(32), CACNA1B(39), GNAS(29), GNAT3(6), GNB1(2), GNB3(5), GNG13(5), GNG3(1), GRM4(21), ITPR3(21), KCNB1(28), PDE1A(17), PLCB2(12), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), SCNN1A(2), SCNN1B(6), SCNN1G(8), TAS1R1(5), TAS1R2(28), TAS1R3(6), TAS2R10(2), TAS2R13(2), TAS2R14(4), TAS2R16(15), TAS2R3(2), TAS2R38(9), TAS2R39(5), TAS2R4(3), TAS2R40(7), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R5(3), TAS2R50(1), TAS2R60(9), TAS2R7(3), TAS2R9(3), TRPM5(11) 44672020 464 242 456 163 85 182 114 29 54 0 0.279 1.000 1.000 165 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(4), AKR1D1(12), ARSD(6), ARSE(5), CARM1(4), CYP11B1(27), CYP11B2(24), CYP19A1(4), HSD11B1(9), HSD17B1(2), HSD17B12(4), HSD17B2(6), HSD17B3(3), HSD17B7(3), HSD3B1(6), HSD3B2(15), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), SULT2B1(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), WBSCR22(3) 39787126 417 240 411 121 40 183 100 39 54 1 0.164 1.000 1.000 166 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(8), ACOX1(5), ACOX2(3), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ANGPTL4(2), APOA1(3), APOA2(1), APOA5(10), APOC3(2), AQP7(7), CD36(4), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP27A1(5), CYP4A11(8), CYP4A22(1), CYP7A1(8), CYP8B1(4), EHHADH(13), FABP2(1), FABP3(4), FABP4(2), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(7), GK2(10), HMGCS2(7), ILK(1), LPL(8), ME1(3), MMP1(11), NR1H3(4), OLR1(8), PCK1(21), PCK2(4), PDPK1(3), PLTP(7), PPARA(4), PPARD(6), PPARG(8), RXRA(1), RXRB(3), RXRG(18), SCD(3), SCP2(4), SLC27A1(4), SLC27A2(4), SLC27A4(4), SLC27A5(7), SLC27A6(24), SORBS1(12), UBC(14), UCP1(3) 52667188 406 234 404 122 51 159 79 50 67 0 0.292 1.000 1.000 167 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), F10(5), F11(13), F12(4), F2(9), F2R(10), F5(40), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), PROC(4), PROS1(30), SERPINC1(5), SERPING1(7) 35804097 443 234 440 122 32 230 77 32 71 1 0.437 1.000 1.000 168 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(3), AKT2(7), AKT3(7), BCL2(5), BCR(11), BLNK(2), BTK(25), CD19(5), CD22(16), CD81(1), CR2(20), CSK(2), DAG1(3), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), INPP5D(11), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(9), NFATC2(15), NR0B2(3), PDK1(6), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), PPP3CB(3), PPP3CC(3), PTPRC(41), RAF1(6), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8) 56687142 406 233 400 138 53 143 98 29 83 0 0.709 1.000 1.000 169 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(6), ACTG2(10), ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), CDC42(1), CFL2(3), FLNA(31), FLNC(55), FSCN1(4), FSCN2(1), FSCN3(14), GDI1(6), GDI2(1), LIMK1(3), MYH2(77), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PFN1(1), PFN2(1), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), VASP(2), WASF1(10), WASL(7) 38011947 392 233 384 132 55 161 69 41 66 0 0.450 1.000 1.000 170 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AGK(6), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AKR1A1(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CEL(8), DAK(4), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), GK(7), GK2(10), GLA(9), GLB1(3), GPAM(6), LCT(50), LIPA(2), LIPC(9), LIPF(8), LIPG(11), LPL(8), MGLL(2), PNLIPRP1(14), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1) 46126752 424 231 416 119 51 174 91 36 71 1 0.0768 1.000 1.000 171 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1C1(4), AKR1C2(2), AKR1C3(5), AKR1C4(4), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), CYP1A1(9), CYP1A2(3), CYP1B1(5), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2F1(3), CYP2S1(3), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHDH(3), EPHX1(7), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), MGST1(1), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14) 45607203 417 231 412 120 37 187 89 33 71 0 0.148 1.000 1.000 172 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(10), ATM(53), ATR(26), BAI1(24), BAX(3), BID(2), CASP3(5), CASP8(6), CASP9(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG1(2), CCNG2(1), CD82(5), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CHEK1(7), CHEK2(10), CYCS(2), DDB2(2), EI24(1), FAS(4), GADD45A(2), GADD45B(1), GADD45G(1), GTSE1(6), IGF1(4), IGFBP3(4), MDM2(5), MDM4(4), PERP(1), PPM1D(8), PTEN(11), RCHY1(2), RFWD2(16), RRM2(6), RRM2B(3), SERPINB5(8), SERPINE1(14), SESN1(1), SESN2(5), SESN3(2), SFN(1), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(3), TP53I3(2), TP73(7), TSC2(13), ZMAT3(5) 50895338 380 229 376 84 36 135 80 45 80 4 0.00880 1.000 1.000 173 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 31 AKT1(3), AKT2(7), AKT3(7), ASAH1(3), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PI3(1), PIK3CB(8), PITX2(8), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), RAF1(6), RGS20(8), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT3(11) 42892749 367 228 358 109 42 146 86 32 61 0 0.330 1.000 1.000 174 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(53), CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), CREB3L1(4), CREB3L3(3), CREB3L4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), GADD45A(2), GBA2(5), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MNAT1(2), MYC(4), MYT1(24), NACA(15), PCNA(1), POLA2(7), POLE(31), POLE2(1), PRIM1(3), RBL1(7), RPA1(2), RPA2(2), RPA3(1), TFDP1(10), TFDP2(7), TNXB(32), WEE1(4) 59306052 354 226 350 92 49 124 63 38 77 3 0.0701 1.000 1.000 175 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 CPEB1(12), ERBB2(12), ERBB4(51), ETS1(8), ETS2(6), ETV6(5), ETV7(2), FMN2(65), GRB2(6), MAP2K1(10), MAPK1(2), MAPK3(3), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), PIWIL1(17), PIWIL2(10), PIWIL3(9), PIWIL4(7), RAF1(6), SOS1(17), SOS2(13), SPIRE1(5), SPIRE2(5) 37790621 387 226 374 96 47 158 76 35 69 2 0.0351 1.000 1.000 176 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(8), APH1A(3), CREBBP(30), CTBP1(2), DLL1(5), DLL3(6), DLL4(2), DTX1(10), DTX2(6), DTX3(6), DTX3L(3), DTX4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), HDAC1(4), HDAC2(8), HES1(2), JAG1(16), JAG2(7), LFNG(3), MAML1(9), MAML2(10), MAML3(9), MFNG(1), NCOR2(30), NCSTN(13), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), NUMB(3), NUMBL(3), PSEN1(6), PSEN2(9), PSENEN(2), PTCRA(8), RBPJ(3), RBPJL(5), RFNG(1), SNW1(3) 54216501 390 224 389 114 63 143 81 38 64 1 0.147 1.000 1.000 177 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2) 40961771 349 223 346 106 42 141 66 40 60 0 0.272 1.000 1.000 178 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2) 40961771 349 223 346 106 42 141 66 40 60 0 0.272 1.000 1.000 179 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(4), ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), G6PC2(8), GALM(2), GAPDH(5), GAPDHS(10), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGAM4(6), PGK1(4), PGK2(27), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 46692040 398 221 393 118 58 163 74 37 66 0 0.133 1.000 1.000 180 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(9), AGT(4), AKT1(3), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK1G(2), CAMK4(16), CREBBP(30), CSNK1A1(2), EDN1(1), ELSPBP1(8), F2(9), GATA4(7), GSK3B(4), HAND1(5), HAND2(10), HRAS(2), IGF1(4), LIF(3), MAP2K1(10), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MEF2C(6), MYH2(77), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKX2-5(8), NPPA(3), PIK3R1(4), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAF1(6), RPS6KB1(3), SYT1(6) 38097920 340 220 335 96 55 137 72 23 52 1 0.0897 1.000 1.000 181 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(33), AXIN1(7), CCND1(3), CCND2(4), CCND3(1), CSNK1E(6), DVL1(5), DVL2(7), DVL3(13), FBXW2(4), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LDLR(9), MAPK10(6), MAPK9(8), MYC(4), PAFAH1B1(1), PPP2R5C(1), PPP2R5E(5), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), RHOA(4), SFRP4(7), TCF7(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4) 46533066 394 219 389 108 87 139 69 28 69 2 0.0274 1.000 1.000 182 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(9), ADAM17(8), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CASP3(5), CDC42(1), CHUK(7), CSK(2), CXCL1(1), F11R(3), GIT1(3), IGSF5(6), IKBKB(9), JAM2(9), JAM3(4), JUN(3), LYN(6), MAP2K4(8), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK8(2), MAPK9(8), MET(22), NFKB1(6), NFKB2(5), NFKBIA(4), NOD1(7), PAK1(9), PLCG1(7), PLCG2(18), PTPN11(9), PTPRZ1(72), RELA(3), SRC(2), TCIRG1(2), TJP1(15) 54282091 364 218 356 124 41 123 70 38 91 1 0.852 1.000 1.000 183 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 ALG2(3), BAK1(3), BAX(3), BFAR(5), BTK(25), CAD(25), CASP10(7), CASP3(5), CASP8(6), CSNK1A1(2), DAXX(8), DEDD(2), DEDD2(3), DFFA(3), DIABLO(1), EPHB2(10), FADD(2), FAF1(10), FAIM2(6), HSPB1(1), IL1A(4), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MET(22), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR0B2(3), PFN1(1), PFN2(1), PTPN13(21), RALBP1(3), RIPK1(11), ROCK1(19), SMPD1(3), TNFRSF6B(1), TPX2(12), TRAF2(5) 55195316 337 218 334 94 32 125 72 37 70 1 0.209 1.000 1.000 184 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(3), APC(33), ASAH1(3), CAMP(4), CAV3(3), DAG1(3), DLG4(7), EPHB2(10), GNAI1(10), GNAQ(5), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PITX2(8), PTX3(3), RHO(7), RYR1(111) 36904482 342 217 337 96 60 118 80 25 57 2 0.0827 1.000 1.000 185 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(4), CD3D(2), CSK(2), CTLA4(3), DAG1(3), EPHB2(10), FBXW7(15), GRAP2(13), GRB2(6), ITK(16), ITPKA(2), ITPKB(7), LAT(4), LCK(9), LCP2(10), MAPK1(2), NCK1(5), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLCG1(7), PTPRC(41), RAF1(6), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), SOS1(17), SOS2(13), VAV1(8), ZAP70(9) 44571429 361 215 351 113 50 141 66 25 79 0 0.493 1.000 1.000 186 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(134), B3GALT4(1), CDR1(15), DGKI(35), IL6ST(3), MRPL19(1), PIGK(3), RPL10(4), RPL11(2), RPL13A(2), RPL14(2), RPL15(1), RPL17(2), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL37(2), RPL3L(8), RPL4(5), RPL41(1), RPL5(8), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPLP0(2), RPLP1(1), RPLP2(3), RPS10(3), RPS11(1), RPS13(1), RPS14(1), RPS15(2), RPS18(2), RPS19(1), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), RPS7(1), RPSA(1), SLC36A2(6), UBA52(1), UBC(14) 41571862 367 213 361 103 38 173 72 27 55 2 0.191 1.000 1.000 187 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(7), AKT3(7), BCR(11), BTK(25), CD19(5), DAPP1(3), FLOT1(1), FLOT2(4), GAB1(7), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), NR0B2(3), PDK1(6), PITX2(8), PLCG2(18), PPP1R13B(7), PREX1(40), PTEN(11), PTPRC(41), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SAG(5), SYK(5), TEC(12), VAV1(8) 42148032 347 212 345 86 46 128 77 21 75 0 0.0123 1.000 1.000 188 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(13), F12(4), F13B(28), F2(9), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), LPA(47), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14), SERPINF2(2), VWF(32) 28374054 380 210 374 103 24 171 80 38 66 1 0.179 1.000 1.000 189 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), AFMID(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(3), CYP1B1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), INMT(8), KMO(9), KYNU(17), LCMT1(5), LCMT2(7), LNX1(9), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NFX1(5), OGDH(10), OGDHL(35), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TDO2(9), TPH1(8), TPH2(16), WARS(6), WARS2(7), WBSCR22(3) 48745420 383 210 376 110 53 128 82 50 70 0 0.160 1.000 1.000 190 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), HSD3B7(7), NSD1(23), OGDH(10), OGDHL(35), PIPOX(2), PLOD1(5), PLOD2(12), PLOD3(10), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SETD1A(18), SETD7(2), SETDB1(11), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(4), TMLHE(9) 46424015 336 209 332 93 50 131 73 33 47 2 0.0900 1.000 1.000 191 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AKR1A1(1), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), CEL(8), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), GK(7), GLA(9), GLB1(3), LCT(50), LIPC(9), LIPF(8), LIPG(11), LPL(8), PNLIPRP1(14), PPAP2A(2), PPAP2B(3), PPAP2C(1) 37689476 361 207 355 90 46 148 74 30 63 0 0.00844 1.000 1.000 192 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CHPT1(3), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), ESCO1(10), ESCO2(4), ETNK1(5), GNPAT(5), GPAM(6), GPD1(3), GPD1L(4), GPD2(9), LCAT(6), NAT6(1), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1), PTDSS1(10), PTDSS2(3) 52161680 368 207 361 118 42 131 92 34 67 2 0.721 1.000 1.000 193 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MIOX(2), OCRL(13), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CB(8), PIK3CG(33), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18) 34137258 312 202 309 85 44 118 67 27 55 1 0.108 1.000 1.000 194 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(6), APAF1(10), ARHGDIB(2), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), GSN(4), LMNA(2), LMNB1(5), LMNB2(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK8(2), MDM2(5), NFKB1(6), NFKBIA(4), NUMA1(16), PAK2(3), PRKCD(7), PRKDC(50), PSEN1(6), PSEN2(9), PTK2(6), RASA1(11), RELA(3), RIPK1(11), SPTAN1(21), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5) 53904554 315 201 314 91 27 101 73 40 74 0 0.558 1.000 1.000 195 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHFR(2), DHX58(4), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), FPGS(3), GCH1(3), GGH(9), IFIH1(10), MOV10L1(11), NUDT5(2), NUDT8(2), PTS(1), QDPR(7), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SKIV2L2(15), SMARCA2(22), SMARCA5(5), SPR(3) 50269127 313 199 311 95 33 102 82 35 61 0 0.533 1.000 1.000 196 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(9), CRK(1), CRKL(4), DOCK1(15), ELK1(3), FOS(3), GAB1(7), GRB2(6), HGF(54), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(2), MET(22), PAK1(9), PIK3R1(4), PTEN(11), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAF1(6), RAP1A(1), RAP1B(2), RASA1(11), SOS1(17), SRC(2), STAT3(11) 33712135 283 198 272 91 23 97 59 40 64 0 0.859 1.000 1.000 197 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 39312877 333 197 329 91 48 135 63 30 57 0 0.0416 1.000 1.000 198 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 39312877 333 197 329 91 48 135 63 30 57 0 0.0416 1.000 1.000 199 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), DRD1(13), DRD3(19), DRD4(2), DRD5(26), HRH1(5), HRH2(17), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11) 19764090 343 197 338 123 51 158 65 26 42 1 0.116 1.000 1.000 200 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EARS2(5), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GFPT2(10), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), GMPS(9), GNPNAT1(1), GOT1(3), GOT2(6), GPT2(5), GSR(5), GSS(4), NADSYN1(2), NAGK(6), PPAT(1), QARS(6) 31784864 300 193 299 75 27 122 53 35 62 1 0.0507 1.000 1.000 201 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ITPA(1), NT5E(5), NT5M(3), NUDT2(3), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), RRM1(6), RRM2(6), TK1(1), TK2(1), TXNRD1(7), TYMS(3), UCK2(10), UMPS(4), UNG(5), UPB1(2), UPP1(6) 45844839 316 193 314 95 39 126 70 31 48 2 0.394 1.000 1.000 202 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), CARM1(4), COMT(1), DBH(12), DCT(16), DDC(8), ECH1(1), ESCO1(10), ESCO2(4), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NAT6(1), PNMT(1), PNPLA3(4), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TAT(9), TH(7), TPO(33), TYR(29), TYRP1(5), WBSCR22(3) 47774422 339 192 334 110 56 123 57 38 65 0 0.435 1.000 1.000 203 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(3), AKT2(7), AKT3(7), CAB39(2), DDIT4(4), EIF4B(7), FIGF(4), HIF1A(2), IGF1(4), MAPK1(2), MAPK3(3), PDPK1(3), PGF(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PRKAA1(6), PRKAA2(8), RHEB(4), RICTOR(25), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), TSC1(10), TSC2(13), ULK1(8), ULK2(9), ULK3(2), VEGFA(1), VEGFB(2), VEGFC(21) 38591681 283 192 280 83 41 114 58 30 39 1 0.269 1.000 1.000 204 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(1), ALAS1(2), ALAS2(6), BLVRA(3), BLVRB(2), COX10(4), CP(11), CPOX(4), EARS2(5), EPRS(27), FECH(4), FTH1(2), FTMT(11), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), MMAB(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), UROS(2) 33340378 299 191 297 92 21 140 71 23 44 0 0.536 1.000 1.000 205 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH4A1(6), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), GATM(8), GLUD1(4), GOT1(3), GOT2(6), MAOA(5), MAOB(3), NOS1(29), NOS3(12), OAT(3), ODC1(1), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), P4HB(5), PYCR1(1), RARS(6), SMS(3) 35307606 282 190 280 90 37 101 55 38 50 1 0.391 1.000 1.000 206 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(7), AKR1B10(10), B4GALT1(1), B4GALT2(4), G6PC(7), G6PC2(8), GAA(12), GALK1(3), GALK2(3), GALT(5), GANC(3), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), HSD3B7(7), LCT(50), MGAM(51), PFKL(9), PFKM(7), PFKP(5), PGM1(3), PGM3(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2), UGP2(4) 30815039 275 190 274 82 46 115 57 20 37 0 0.131 1.000 1.000 207 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CAT(3), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADHA(3), KMO(9), KYNU(17), MAOA(5), MAOB(3), SDS(4), TDO2(9), TPH1(8), WARS(6), WARS2(7) 44374676 344 190 340 115 43 127 70 44 60 0 0.628 1.000 1.000 208 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(4), ALDOB(8), ALDOC(2), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GAPDHS(10), GCK(6), GOT1(3), GOT2(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6B(3), LDHB(4), LDHC(6), MDH1(3), MDH2(3), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PDHX(4), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGK1(4), PGK2(27), PKLR(16), TNFAIP1(1), TPI1(9) 34015838 316 189 315 95 52 131 50 34 49 0 0.115 1.000 1.000 209 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(17), CALCR(27), CALCRL(18), CD97(12), CRHR1(7), EMR1(24), EMR2(13), GHRHR(5), GIPR(3), GLP1R(11), GLP2R(17), GPR64(14), LPHN1(7), LPHN2(47), LPHN3(78), SCTR(5), VIPR1(2), VIPR2(3) 20181072 310 188 307 97 34 129 57 36 53 1 0.264 1.000 1.000 210 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(10), CDC42(1), DLD(9), DUSP10(11), DUSP4(2), DUSP8(2), GAB1(7), GADD45A(2), GCK(6), IL1R1(2), JUN(3), MAP2K4(8), MAP2K5(4), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK10(6), MAPK7(7), MAPK8(2), MAPK9(8), MYEF2(12), NFATC3(15), NR2C2(2), PAPPA(32), SHC1(6), TRAF6(6), ZAK(7) 39690272 296 188 294 74 44 116 51 27 58 0 0.0784 1.000 1.000 211 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(7), ARRB2(4), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CLCA1(14), CLCA2(29), CLCA4(30), CNGA3(15), CNGA4(15), CNGB1(10), GNAL(5), GUCA1A(7), GUCA1B(4), GUCA1C(7), PDC(1), PDE1C(28), PRKACA(3), PRKACB(9), PRKACG(4), PRKG1(20), PRKG2(15), PRKX(3) 24535411 271 187 270 86 28 118 53 22 50 0 0.440 1.000 1.000 212 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), BIRC2(2), BIRC3(4), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), GZMB(6), HELLS(4), IKBKB(9), IRF1(1), IRF2(3), IRF4(12), IRF5(1), IRF6(12), IRF7(3), JUN(3), LTA(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), NFKBIB(3), NFKBIE(2), PLEKHG5(10), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFSF10(3), TP73(7), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4) 45200856 298 186 299 86 27 116 61 31 63 0 0.328 1.000 1.000 213 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPS(6), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CLC(3), CPT1B(6), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), ETNK1(5), GNPAT(5), GPD1(3), GPD2(9), LCAT(6), LGALS13(5), PAFAH1B1(1), PAFAH2(3), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB2(12), PLCG1(7), PLCG2(18), PPAP2A(2), PPAP2B(3), PPAP2C(1) 39734673 307 186 301 99 45 100 77 26 58 1 0.552 1.000 1.000 214 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(23), GABBR1(8), GPRC5A(3), GPRC5B(14), GPRC5C(10), GPRC5D(2), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM7(43), GRM8(52) 16886110 290 183 287 86 49 128 67 17 28 1 0.0406 1.000 1.000 215 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(2), ACOX1(5), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP4A11(8), CYP4A22(1), ECHS1(4), EHHADH(13), GCDH(7), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8) 39393905 254 183 248 66 35 88 49 32 50 0 0.0878 1.000 1.000 216 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 CALR(2), CANX(5), CD4(8), CD8A(4), CD8B(5), CIITA(5), CREB1(2), CTSB(2), CTSS(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), HSP90AA1(8), HSP90AB1(9), HSPA5(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KIR3DL3(2), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LGMN(4), LTA(3), NFYA(1), NFYB(1), NFYC(6), PDIA3(4), PSME1(2), PSME2(3), RFX5(9), RFXANK(1), TAP1(1), TAP2(8), TAPBP(4) 36952896 256 183 249 82 22 104 58 28 44 0 0.645 1.000 1.000 217 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 AKT1(3), APC(33), AR(10), ASAH1(3), CAMP(4), CCL13(3), CCL15(5), CCL16(4), DAG1(3), GNA11(4), GNA15(1), GNAI1(10), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), MAPK10(6), MAPK14(4), PHKA2(14), PIK3CD(4), PIK3R1(4), PITX2(8), PTX3(3), RAF1(6), SRC(2) 37709961 279 183 272 75 34 101 67 17 60 0 0.174 1.000 1.000 218 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(38), AR(10), ESR1(12), ESR2(6), HNF4A(21), NPM1(5), NR0B1(14), NR1D1(2), NR1D2(1), NR1H2(5), NR1H3(4), NR1I2(4), NR1I3(9), NR2C2(2), NR2E1(9), NR2F1(7), NR2F2(1), NR2F6(1), NR3C1(8), NR4A1(5), NR4A2(18), NR5A1(6), NR5A2(14), PGR(15), PPARA(4), PPARD(6), PPARG(8), RARA(7), RARB(7), RARG(3), ROR1(13), RORA(9), RORC(1), RXRA(1), RXRB(3), RXRG(18), THRA(5), THRB(4), VDR(4) 33642017 310 182 309 108 45 126 66 20 52 1 0.662 1.000 1.000 219 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(5), APOA1(3), APOA2(1), CD36(4), CITED2(3), CPT1B(6), CREBBP(30), DUSP1(1), EHHADH(13), EP300(11), HSD17B4(8), JUN(3), LPL(8), MAPK1(2), MAPK3(3), ME1(3), MRPL11(1), MYC(4), NCOA1(18), NCOR1(23), NCOR2(30), NFKBIA(4), NR0B2(3), NR1H3(4), NR2F1(7), NRIP1(13), PDGFA(5), PIK3R1(4), PPARA(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PTGS2(12), RELA(3), RXRA(1), SP1(6), STAT5A(3), STAT5B(8), TNF(2) 47429760 293 182 290 91 48 103 59 30 52 1 0.389 1.000 1.000 220 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(3), AKT2(7), AKT3(7), BRD4(7), CBL(10), CDC42(1), F2RL2(12), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), LNPEP(5), MAPK1(2), MAPK3(3), PARD3(15), PARD6A(1), PDK1(6), PIK3CD(4), PIK3R1(4), PTEN(11), PTPN1(3), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SERPINB6(3), SFN(1), SHC1(6), SLC2A4(4), SORBS1(12), SOS1(17), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 44911241 285 182 280 78 38 114 68 18 46 1 0.153 1.000 1.000 221 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(7), AKT3(7), ARHGEF11(24), BCL2(5), CDC42(1), DLG4(7), GNA13(6), LPA(47), MAP2K4(8), MAP3K1(7), MAP3K5(14), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PI3(1), PIK3CB(8), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RDX(2), ROCK1(19), ROCK2(9), SERPINA4(16), SRF(1), TBXA2R(1) 39339807 272 182 268 72 25 115 50 32 50 0 0.170 1.000 1.000 222 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(53), ATR(26), BRCA1(22), CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CDC34(2), CDKN1A(2), CDKN2D(2), CHEK1(7), CHEK2(10), EP300(11), GADD45A(2), MDM2(5), MYT1(24), PRKDC(50), RPS6KA1(6), WEE1(4), YWHAH(1), YWHAQ(4) 32988191 246 180 244 39 19 75 50 36 64 2 0.000718 1.000 1.000 223 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(14), AADAC(5), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(10), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH7A1(3), ALDH9A1(3), BDH1(4), BDH2(2), DDHD1(11), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADH(2), HADHA(3), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), HSD3B7(7), ILVBL(3), L2HGDH(6), OXCT1(7), OXCT2(2), PDHA1(5), PDHA2(29), PLA1A(6), PPME1(6), PRDX6(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 32639019 282 180 280 88 32 105 64 26 53 2 0.489 1.000 1.000 224 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(20), ACACB(28), ACAT1(2), ACAT2(2), ACOT12(11), ACSS1(5), ACSS2(4), ACYP2(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PCK2(4), PDHA1(5), PDHA2(29), PKLR(16) 37616402 283 179 282 93 43 109 49 30 52 0 0.563 1.000 1.000 225 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), ELK1(3), FPR1(10), GNA15(1), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PAK1(9), PIK3C2G(19), PLCB1(52), PPP3CB(3), PPP3CC(3), RAF1(6), RELA(3), SYT1(6) 29794818 248 177 241 67 29 108 44 18 49 0 0.109 1.000 1.000 226 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(13), ATP4A(16), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5E(1), ATP5F1(3), ATP5G3(2), ATP5J2(3), ATP5L(3), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6B2(1), COX6C(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(7), LHPP(3), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA12(5), NDUFA13(1), NDUFA4(2), NDUFA5(2), NDUFA6(1), NDUFA7(1), NDUFA8(5), NDUFA9(4), NDUFB1(1), NDUFB10(3), NDUFB11(6), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFB8(1), NDUFB9(2), NDUFC2(3), NDUFS1(10), NDUFS2(4), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(2), NDUFV1(2), NDUFV2(1), NDUFV3(1), PPA1(2), SDHA(8), SDHB(1), SDHD(3), TCIRG1(2), UQCRB(5), UQCRC1(2), UQCRC2(5), UQCRFS1(3), UQCRH(3), UQCRQ(2) 44713921 281 177 278 104 47 92 57 24 59 2 0.863 1.000 1.000 227 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ASL(4), ASS1(5), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), EPRS(27), GATM(8), GLUD1(4), GLUD2(15), GOT1(3), GOT2(6), LAP3(4), NOS1(29), NOS3(12), OAT(3), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), PARS2(1), PRODH(4), PYCR1(1), PYCR2(6), PYCRL(1), RARS(6), RARS2(6) 28625139 264 177 261 73 29 111 51 29 43 1 0.114 1.000 1.000 228 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(5), ALOX12(8), ALOX12B(7), ALOX15(5), ALOX15B(6), ALOX5(10), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP2U1(2), CYP4A11(8), CYP4A22(1), CYP4F2(15), CYP4F3(16), DHRS4(1), EPHX2(3), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), LTA4H(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11) 31159882 266 177 263 76 38 104 60 25 39 0 0.121 1.000 1.000 229 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(5), CHUK(7), DAXX(8), EGF(13), ETS1(8), ETS2(6), FOS(3), HOXA7(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(4), PPP2CA(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), RAF1(6), RELA(3), RIPK1(11), SP1(6), TNF(2), TNFRSF1B(2), TRAF2(5) 37301556 252 177 248 91 29 85 53 29 54 2 0.904 1.000 1.000 230 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(3), CALM2(1), CD3D(2), CD3E(2), ELK1(3), FOS(3), FYN(8), GRB2(6), HRAS(2), JUN(3), LAT(4), LCK(9), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PIK3R1(4), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), PTPN7(1), RAF1(6), RASA1(11), RELA(3), SHC1(6), SOS1(17), SYT1(6), VAV1(8), ZAP70(9) 35847130 230 177 225 76 37 82 40 20 51 0 0.625 1.000 1.000 231 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GLS(8), GLS2(6), GLUD1(4), GLUL(6), GMPS(9), GOT1(3), GOT2(6), GPT2(5), GSS(4), NADSYN1(2), PPAT(1), QARS(6) 26707796 258 176 257 66 23 103 44 31 56 1 0.115 1.000 1.000 232 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), AKT2(7), AKT3(7), BCR(11), BLNK(2), BTK(25), CD19(5), CSK(2), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PI3(1), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), RAF1(6), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8) 40273382 248 176 240 81 29 84 63 24 48 0 0.630 1.000 1.000 233 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(7), ELK1(3), FOS(3), IKBKB(9), IRAK1(6), JUN(3), LY96(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), PPARA(4), RELA(3), TLR10(16), TLR2(10), TLR3(4), TLR4(64), TLR6(11), TLR7(17), TLR9(9), TOLLIP(2), TRAF6(6) 29367557 241 176 240 80 15 100 47 26 53 0 0.752 1.000 1.000 234 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(53), BMPR1B(7), CCND2(4), CDK4(3), CDKN1B(5), DAZL(2), DMC1(1), EGR1(6), ESR2(6), FSHR(37), GJA4(6), INHA(1), LHCGR(14), MLH1(8), MSH5(8), NCOR1(23), NR5A1(6), NRIP1(13), PGR(15), PRLR(18), PTGER2(4), SMPD1(3), VDR(4), ZP2(5) 28059230 252 175 247 55 36 92 51 28 43 2 0.0177 1.000 1.000 235 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), AKR1D1(12), ARSB(6), ARSD(6), ARSE(5), CYP11B1(27), CYP11B2(24), HSD11B1(9), HSD17B2(6), HSD17B3(3), HSD3B1(6), HSD3B2(15), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28) 22158661 257 174 254 75 21 117 64 24 30 1 0.196 1.000 1.000 236 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(6), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDK5(3), F2(9), FYN(8), GNA11(4), GNAI1(10), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), JAK2(16), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MAPT(15), MYLK(26), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), SYT1(6) 33357943 256 174 251 77 45 87 46 28 50 0 0.295 1.000 1.000 237 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(7), B4GALT1(1), B4GALT2(4), FBP2(2), G6PC(7), GAA(12), GALK1(3), GALK2(3), GALT(5), GANAB(9), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), LCT(50), MGAM(51), PFKM(7), PFKP(5), PGM1(3), PGM3(3) 26076697 235 174 234 67 37 102 48 16 32 0 0.0743 1.000 1.000 238 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(5), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GCNT1(8), GCNT3(2), GCNT4(9), OGT(19), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(8), WBSCR17(33) 26072743 259 174 255 98 35 99 69 22 34 0 0.966 1.000 1.000 239 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(8), AGXT2(13), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), GNMT(1), HSD3B7(7), MAOA(5), MAOB(3), PEMT(2), PHGDH(7), PIPOX(2), PISD(2), PSAT1(5), PSPH(6), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SARDH(10), SARS(5), SARS2(4), SDS(4), SHMT1(2), SHMT2(2), TARS(14), TARS2(11) 34156007 250 173 249 82 37 91 53 27 41 1 0.383 1.000 1.000 240 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(9), ACTN1(7), ACTN2(43), BCAR1(3), BCR(11), CAPN1(2), CAPNS1(1), CAPNS2(2), CAV1(1), CRKL(4), CSK(2), FYN(8), GRB2(6), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(2), PPP1R12B(15), PTK2(6), PXN(1), RAF1(6), RAP1A(1), ROCK1(19), SHC1(6), SOS1(17), SRC(2), TLN1(15), VCL(8), ZYX(6) 37582153 244 171 238 85 34 84 53 32 41 0 0.761 1.000 1.000 241 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(3), ASAH1(3), ATF1(1), CAMP(4), CREB1(2), CREB5(18), CREBBP(30), CRKL(4), DAG1(3), EGR1(6), EGR2(4), EGR3(1), EGR4(3), ELK1(3), FRS2(10), GNAQ(5), JUN(3), MAP1B(29), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), NTRK1(14), OPN1LW(9), PIK3C2G(19), PIK3CD(4), PIK3R1(4), PTPN11(9), RPS6KA3(6), SHC1(6), SRC(2), TH(7) 37876993 261 171 258 80 48 101 52 16 43 1 0.173 1.000 1.000 242 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(7), APC(33), ATF2(10), AXIN1(7), BMP10(11), BMP2(1), BMP4(6), BMP5(6), BMP7(12), BMPR1A(4), BMPR2(10), CHRD(13), DVL1(5), FZD1(6), GATA4(7), GSK3B(4), MAP3K7(10), MEF2C(6), MYL2(8), NKX2-5(8), NOG(1), NPPA(3), NPPB(3), RFC1(13), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), WNT1(6) 27853591 246 170 242 66 36 90 45 25 50 0 0.233 1.000 1.000 243 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(9), CARS(4), CARS2(3), DARS(3), DARS2(4), EARS2(5), EPRS(27), FARS2(5), FARSA(5), FARSB(5), GARS(3), HARS(5), HARS2(4), IARS(9), IARS2(15), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), MTFMT(1), NARS(4), NARS2(6), PARS2(1), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(4), TARS(14), TARS2(11), VARS(10), VARS2(2), WARS(6), WARS2(7), YARS(3), YARS2(10) 43790134 254 170 251 63 27 95 56 24 52 0 0.0730 1.000 1.000 244 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(25), CALM1(3), CALM2(1), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PAK2(3), PIK3R1(4), PLA2G4A(21), PLCG1(7), PPP3CB(3), PPP3CC(3), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8) 31910439 241 169 236 65 31 87 56 18 49 0 0.156 1.000 1.000 245 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG5(1), ALG6(1), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), DAD1(2), DDOST(1), DHDDS(2), DOLPP1(1), DPAGT1(5), DPM1(5), FUT8(7), GANAB(9), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), RFT1(4), RPN1(3), RPN2(4), ST6GAL1(4), STT3B(4) 33965732 235 169 235 63 28 96 43 28 40 0 0.159 1.000 1.000 246 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 CALM1(3), CALM2(1), DLG4(7), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), NOS1(29), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), SYT1(6) 19540856 226 169 223 75 43 94 45 13 29 2 0.314 1.000 1.000 247 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), DAG1(3), DGKA(7), GCA(3), ITGA9(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAPK1(2), MAPK3(3), NR1I3(9), PAK1(9), PDE3A(30), PDE3B(16), PI3(1), PIK3C2G(19), PIK3CD(4), PIK3R1(4), PSME1(2), RIPK3(5), RPS4X(2), SGCB(4), VASP(2) 37302013 245 168 241 62 29 80 52 25 58 1 0.0977 1.000 1.000 248 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(2), B3GALT1(5), B3GALT2(4), B3GALT4(1), B3GALT5(3), B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALNT1(9), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT6(5), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GBGT1(2), GCNT2(5), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGX(4), PIGZ(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST3GAL5(3), ST3GAL6(6), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12), UGCG(2) 38645581 260 167 258 98 39 93 58 26 44 0 0.828 1.000 1.000 249 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(6), ARSB(6), FUCA1(2), FUCA2(3), GALNS(3), GBA(7), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NAGLU(5), NEU1(2), NEU2(7), NEU3(5), NEU4(13), SPAM1(25) 27360330 219 167 218 78 30 98 35 27 29 0 0.682 1.000 1.000 250 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(4), ACTR3(2), ARHGAP1(5), ARHGAP4(14), ARHGAP5(17), ARHGAP6(17), ARHGEF1(5), ARHGEF11(24), ARHGEF5(4), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), BAIAP2(3), DIAPH1(3), GSN(4), LIMK1(3), MYL2(8), MYLK(26), OPHN1(16), PFN1(1), PIP5K1A(6), PIP5K1B(6), PPP1R12B(15), ROCK1(19), SRC(2), TLN1(15), VCL(8) 36548965 239 167 237 65 34 86 41 26 52 0 0.109 1.000 1.000 251 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(22), CARM1(4), CCND1(3), CREBBP(30), EP300(11), ERCC3(5), ESR1(12), GRIP1(13), GTF2A1(3), GTF2E1(8), GTF2F1(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), MEF2C(6), NCOR2(30), NR0B1(14), NRIP1(13), PELP1(10), POLR2A(11), TBP(1) 36770103 251 166 251 73 38 94 64 14 41 0 0.268 1.000 1.000 252 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(26), CALM1(3), CALM2(1), CREB1(2), ELK1(3), FOS(3), GNAI1(10), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), JUN(3), MAP2K1(10), MAPK3(3), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RAF1(6), RPS6KA3(6), SYT1(6) 27060539 223 166 217 65 47 94 36 15 29 2 0.180 1.000 1.000 253 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(10), BAX(3), BCL2(5), BCL2A1(1), BCL2L1(3), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CD40(3), CD40LG(9), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKE(9), LTA(3), MCL1(1), NFKB1(6), NFKBIA(4), NGFR(5), NR3C1(8), NTRK1(14), PTPN13(21), RIPK1(11), TFG(4), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4), TRAF6(6) 34956034 236 164 235 90 15 96 56 27 41 1 0.958 1.000 1.000 254 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(4), CDC7(6), CDK2(1), CDT1(1), DIAPH2(18), GMNN(1), MCM10(10), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), NACA(15), PCNA(1), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), PRIM1(3), RFC1(13), RFC2(4), RFC3(3), RFC4(7), RFC5(3), RPA1(2), RPA2(2), RPA3(1), RPA4(8), UBA52(1), UBC(14) 40583197 230 163 230 64 28 79 54 24 44 1 0.436 1.000 1.000 255 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(8), AGXT2(13), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), ATP6V0C(4), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CPT1B(6), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), MAOA(5), MAOB(3), PEMT(2), PISD(2), PLCB2(12), PLCG1(7), PLCG2(18), PSPH(6), SARDH(10), SARS(5), SHMT1(2), SHMT2(2), TARS(14) 33546941 236 163 234 81 41 76 53 29 36 1 0.551 1.000 1.000 256 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(9), ABAT(12), ACY3(4), ADSL(2), ADSS(6), ADSSL1(4), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), ASRGL1(3), ASS1(5), CAD(25), DARS(3), DARS2(4), DDO(5), DLAT(10), DLD(9), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), NARS2(6), PC(9), PDHA1(5), PDHA2(29) 30242893 244 162 244 66 35 94 49 23 42 1 0.0995 1.000 1.000 257 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), AMDHD1(4), AOC2(6), AOC3(11), ASPA(5), CARM1(4), CNDP1(10), DDC(8), FTCD(8), HAL(5), HARS(5), HARS2(4), HDC(16), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), PRPS1(3), PRPS2(4), UROC1(14), WBSCR22(3) 31764646 223 162 221 69 44 73 43 24 39 0 0.235 1.000 1.000 258 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(5), CDK5(3), CDK5R1(3), CHN1(8), LIMK1(3), MAP3K1(7), MYL2(8), MYLK(26), NCF2(8), PAK1(9), PDGFRA(41), PIK3R1(4), PLD1(19), PPP1R12B(15), RALBP1(3), RPS6KB1(3), TRIO(37), VAV1(8), WASF1(10) 26477345 220 162 218 62 22 86 49 15 46 2 0.244 1.000 1.000 259 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(53), ATR(26), BRCA1(22), BRCA2(31), CHEK1(7), CHEK2(10), FANCA(7), FANCC(2), FANCD2(4), FANCE(3), FANCF(4), FANCG(7), HUS1(4), MRE11A(13), RAD1(1), RAD17(6), RAD50(10), RAD51(2), RAD9A(2), TREX1(1) 34908100 215 160 212 33 16 65 50 35 47 2 0.00220 1.000 1.000 260 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), XYLB(6) 21297464 221 160 219 61 9 105 53 20 34 0 0.335 1.000 1.000 261 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(7), AKR1B10(10), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), FUK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), HSD3B7(7), KHK(3), LHPP(3), MPI(4), MTMR1(11), MTMR2(2), MTMR6(9), PFKFB1(10), PFKFB2(2), PFKFB3(7), PFKFB4(6), PFKL(9), PFKM(7), PFKP(5), PGM2(8), PHPT1(1), PMM1(3), PMM2(1), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SORD(2), TPI1(9), TSTA3(1) 29574893 231 160 230 64 46 85 44 18 38 0 0.0514 1.000 1.000 262 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ATP6V0C(4), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADHA(3), PLOD1(5), PLOD2(12), PLOD3(10), SDS(4), SHMT1(2), SHMT2(2), TMLHE(9) 29411929 224 160 221 62 30 87 49 28 29 1 0.157 1.000 1.000 263 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(3), AKT2(7), AKT3(7), ANKRD6(2), APC(33), AXIN1(7), AXIN2(5), CER1(7), CSNK1A1(2), DACT1(24), DKK1(3), DKK2(14), DKK4(2), DVL1(5), FSTL1(4), GSK3A(1), GSK3B(4), LRP1(36), MVP(6), NKD1(6), NKD2(8), PIN1(1), PSEN1(6), PTPRA(11), SENP2(6), SFRP1(2), TSHB(5), WIF1(3) 30930555 220 160 217 73 34 92 34 19 41 0 0.601 1.000 1.000 264 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(10), CD2(6), CD33(13), CD5(7), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(4), IL4(1), IL5(2), ITGAX(52), TLR2(10), TLR4(64), TLR7(17), TLR9(9) 15018623 220 159 219 65 19 111 35 21 32 2 0.0772 1.000 1.000 265 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(2), BTK(25), CALM1(3), CALM2(1), CD79A(2), CD79B(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK14(4), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8) 29895828 205 158 200 57 30 80 43 16 36 0 0.192 1.000 1.000 266 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(12), ACAA2(2), ACADM(8), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), AOX1(22), AUH(2), BCAT1(3), BCAT2(2), BCKDHA(1), DBT(8), DLD(9), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HADHB(10), HIBADH(2), HIBCH(4), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), OXCT2(2), PCCA(6), PCCB(3) 34088869 226 158 224 65 23 71 64 23 44 1 0.510 1.000 1.000 267 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(20), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(2), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PKLR(16) 29693112 242 158 241 64 34 93 45 28 42 0 0.0983 1.000 1.000 268 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(5), ALOX12(8), ALOX15(5), ALOX5(10), CYP4F2(15), CYP4F3(16), EPX(14), GGT1(1), LPO(7), LTA4H(3), MPO(15), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11), TPO(33) 22337017 240 157 236 76 38 81 61 25 35 0 0.344 1.000 1.000 269 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(2), CASP2(13), CASP3(5), CASP8(6), CRADD(3), DFFA(3), DFFB(4), FADD(2), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MADD(22), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), RIPK1(11), SPTAN1(21), TNF(2), TRADD(2), TRAF2(5) 29556400 205 157 201 46 19 58 54 25 49 0 0.0900 1.000 1.000 270 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(10), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2F1(4), GTF2H1(4), GTF2H3(1), GTF2H4(1), GTF2I(7), GTF2IRD1(10), STON1(11), TAF1(22), TAF1L(65), TAF2(13), TAF4(13), TAF4B(6), TAF5(5), TAF5L(9), TAF6(3), TAF6L(3), TAF7(3), TAF7L(6), TAF9(3), TAF9B(5), TBPL1(1), TBPL2(4) 29022582 224 156 224 51 28 81 49 21 43 2 0.0807 1.000 1.000 271 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(10), CDC42(1), CREB1(2), DAXX(8), DDIT3(2), ELK1(3), GRB2(6), HMGN1(1), HRAS(2), HSPB1(1), HSPB2(1), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MYC(4), PLA2G4A(21), RIPK1(11), RPS6KA5(10), SHC1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5) 29475986 221 156 220 49 21 88 46 22 44 0 0.0357 1.000 1.000 272 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(3), APC(33), AXIN1(7), CCND1(3), CD14(1), DVL1(5), FZD1(6), GJA1(11), GNAI1(10), GSK3B(4), IRAK1(6), LBP(8), LEF1(12), LY96(3), MYD88(1), NFKB1(6), PDPK1(3), PIK3R1(4), PPP2CA(1), RELA(3), TLR4(64), TOLLIP(2), WNT1(6) 21417618 202 155 199 53 24 85 31 17 45 0 0.122 1.000 1.000 273 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(21), EEF1A2(8), EEF1B2(7), EEF1D(2), EEF1G(2), EEF2(7), EEF2K(7), EIF1AX(3), EIF2AK1(12), EIF2AK2(5), EIF2AK3(12), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4EBP2(1), EIF4G1(19), EIF4G3(20), EIF5(1), EIF5A(2), EIF5B(14), GSPT2(8), PABPC1(5), PABPC3(15), PAIP1(6), SLC35A4(1) 34830836 209 155 208 54 16 79 55 25 34 0 0.246 1.000 1.000 274 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(2), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CFLAR(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAF1(10), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), PTPN13(21), RIPK2(2), SPTAN1(21) 31228628 203 154 199 54 13 59 52 27 52 0 0.533 1.000 1.000 275 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 ELK1(3), GNAS(29), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), IGF1R(8), ITGB1(6), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MYC(4), NGFR(5), PDGFRA(41), PPP2CA(1), PTPRR(16), RAF1(6), RPS6KA1(6), RPS6KA5(10), SHC1(6), SOS1(17), SRC(2), STAT3(11) 24347074 219 153 210 61 32 91 43 24 28 1 0.222 1.000 1.000 276 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1B10(10), AKR1C4(4), AKR1D1(12), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), HSD3B7(7), LIPA(2), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SLC27A5(7), SOAT1(8), SOAT2(2), SRD5A1(4) 25394461 206 153 203 63 19 81 48 22 36 0 0.368 1.000 1.000 277 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(6), ARSE(5), ASAH1(3), B4GALT6(5), CERK(4), DEGS1(2), DEGS2(1), ENPP7(11), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SGMS1(4), SGMS2(3), SGPP1(3), SGPP2(2), SMPD1(3), SMPD3(6), SMPD4(13), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(2), UGT8(8) 28419660 211 152 209 67 37 99 42 11 22 0 0.198 1.000 1.000 278 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), COMT(1), DBH(12), DCT(16), DDC(8), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), MAOA(5), MAOB(3), PNMT(1), TAT(9), TH(7), TPO(33), TYR(29) 25458965 246 152 243 80 38 97 35 28 48 0 0.292 1.000 1.000 279 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(26), ARHGEF1(5), F2(9), F2R(10), F2RL3(2), GNA12(1), GNA13(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), MAP3K7(10), PIK3R1(4), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2B(14), ROCK1(19) 18943047 206 151 204 47 27 88 33 16 41 1 0.0112 1.000 1.000 280 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PDGFA(5), PDGFRA(41), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3) 26414089 192 151 187 54 26 55 38 26 46 1 0.400 1.000 1.000 281 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(9), AGT(4), AGTR1(9), AGTR2(6), CMA1(8), COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), REN(6) 20378769 234 149 233 81 20 133 35 13 32 1 0.955 1.000 1.000 282 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(12), ACACA(20), ACACB(28), ACADM(8), ACAT1(2), ACAT2(2), ACSS1(5), ACSS2(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), HIBCH(4), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 31991829 204 149 203 69 26 74 43 17 44 0 0.819 1.000 1.000 283 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(10), ADCY3(7), ADCY9(12), ARF1(1), ARF3(1), ARF5(2), ARF6(1), ARL4D(4), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(5), GNAS(29), PDIA4(8), PLCG1(7), PLCG2(18), PRKCA(10), SEC61A1(5), SEC61A2(6), SEC61G(3), TRIM23(4) 29658651 204 148 198 65 34 79 40 16 34 1 0.397 1.000 1.000 284 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(10), BCR(11), BLNK(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8IP3(7), PAPPA(32), RPS6KA1(6), RPS6KA3(6), SHC1(6), SOS1(17), SYK(5), VAV1(8), VAV2(8), VAV3(32) 25525164 195 148 191 51 25 71 39 24 35 1 0.120 1.000 1.000 285 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(11), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPHN(5), NSF(4), SRC(2), UBQLN1(6) 9626774 188 146 185 62 23 91 33 19 22 0 0.612 1.000 1.000 286 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(13), C5(6), C6(29), ICAM1(2), IL1A(4), IL6(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELP(29), SELPLG(2), TNF(2), VCAM1(28) 18720064 195 146 195 64 14 80 50 19 31 1 0.746 1.000 1.000 287 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(10), F2RL3(2), GNAI1(10), GNB1(2), GNGT1(6), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), PLA2G4A(21), PLCB1(52), PRKCA(10), PTGS1(18), PTK2(6), RAF1(6), SRC(2), SYK(5), TBXAS1(11) 19547606 207 146 202 46 21 94 41 20 31 0 0.0126 1.000 1.000 288 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9) 18346764 198 144 191 55 40 70 37 12 37 2 0.243 1.000 1.000 289 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(4), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), LIMK1(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), NOX1(8), PIK3C2G(19), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2(6), RAF1(6), ROCK2(9) 20171859 201 144 194 43 32 84 39 18 28 0 0.0272 1.000 1.000 290 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9) 18346764 198 144 191 55 40 70 37 12 37 2 0.243 1.000 1.000 291 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(26), AKT1(3), ASAH1(3), GNAI1(10), GNB1(2), GNGT1(6), ITGAV(14), ITGB3(13), MAPK1(2), MAPK3(3), PDGFA(5), PDGFRA(41), PIK3R1(4), PLCB1(52), PRKCA(10), PTK2(6), SMPD1(3), SRC(2) 20281668 205 144 203 63 22 84 43 17 37 2 0.322 1.000 1.000 292 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(8), ASRGL1(3), CA1(6), CA12(2), CA13(1), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), HAL(5) 17120398 183 144 182 58 17 80 31 23 32 0 0.590 1.000 1.000 293 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), BTRC(12), CDC16(2), CDC20(8), CDC23(3), CDC27(7), CUL1(14), CUL2(8), CUL3(13), FBXW11(2), FBXW7(15), FZR1(3), ITCH(8), SKP1(4), SKP2(3), SMURF1(8), SMURF2(4), TCEB1(2), UBA1(4), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(4), UBE2E3(6), VHL(1), WWP1(13), WWP2(7) 32170628 198 144 197 46 27 61 41 31 38 0 0.0754 1.000 1.000 294 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(3), AKT2(7), AKT3(7), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PIK3CB(8), PITX2(8), PLD1(19), PLD2(7), PLD3(4), VN1R1(2) 35811416 208 144 207 59 23 79 43 19 43 1 0.281 1.000 1.000 295 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(16), CAMK2D(7), DAG1(3), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFAT5(13), PDE6A(17), PDE6B(15), PDE6C(12), PDE6G(3), SLC6A13(12), TF(13) 28645135 204 144 203 62 28 73 49 20 33 1 0.384 1.000 1.000 296 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(4), AKT1(3), AKT2(7), AKT3(7), BTK(25), DAPP1(3), GRB2(6), GSK3A(1), GSK3B(4), IARS(9), IGFBP1(6), INPP5D(11), PDK1(6), PPP1R13B(7), PTEN(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SOS1(17), SOS2(13), TEC(12), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 26754860 194 143 191 49 20 78 44 14 38 0 0.154 1.000 1.000 297 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(5), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), ELAVL1(5), FLT1(31), FLT4(20), HIF1A(2), HRAS(2), KDR(56), NOS3(12), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PXN(1), SHC1(6), VHL(1) 25304018 188 143 185 55 30 71 32 18 37 0 0.297 1.000 1.000 298 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(12), ACADL(4), ACADM(8), ACADSB(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), MLYCD(2), SDS(4), SMS(3), UPB1(2) 23401329 213 141 211 52 26 84 39 22 41 1 0.0375 1.000 1.000 299 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), AKT2(7), AKT3(7), CISH(1), GRB2(6), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(10), INPP5D(11), JAK1(11), JAK2(16), JAK3(10), NR0B2(3), PI3(1), PPP1R13B(7), RPS6KB1(3), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT6(2), TYK2(5) 27775707 175 141 171 63 23 67 39 20 26 0 0.849 1.000 1.000 300 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), P4HB(5), SLC23A1(3), SLC23A2(8), SLC2A1(1), SLC2A3(10) 20161255 219 140 218 71 23 119 34 10 32 1 0.753 1.000 1.000 301 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(13), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(29), ATP7B(22), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6C(1), COX8A(1), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1), SDHA(8), SDHB(1), SHMT1(2), UQCRB(5), UQCRC1(2), UQCRFS1(3), UQCRH(3) 30733115 208 139 205 78 34 79 30 22 41 2 0.800 1.000 1.000 302 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(14), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HMGCL(1), L2HGDH(6), OXCT1(7), PDHA1(5), PDHA2(29), SDHB(1), SDS(4) 20733189 189 138 188 58 22 70 40 20 36 1 0.460 1.000 1.000 303 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(5), ACO2(3), CLYBL(5), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), OGDHL(35), PC(9), PCK1(21), PCK2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 24111107 171 138 170 65 28 61 24 25 33 0 0.761 1.000 1.000 304 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(19), POLA2(7), POLB(4), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLG(12), POLG2(3), POLH(1), POLI(3), POLK(3), POLL(7), POLM(6), POLQ(36), PRIM1(3), REV1(10), REV3L(20), RFC5(3) 31959465 184 138 183 49 22 71 45 23 23 0 0.367 1.000 1.000 305 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(4), AGTR1(9), ATF2(10), CALM1(3), CALM2(1), ELK1(3), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PAK1(9), PRKCA(10), PTK2(6), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6) 24812007 169 137 162 47 24 65 24 18 38 0 0.314 1.000 1.000 306 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(9), EPHA4(18), EPHB1(44), FYN(8), ITGA1(14), ITGB1(6), L1CAM(42), LYN(6), RAP1B(2), SELP(29) 12772799 178 137 177 47 28 68 33 22 25 2 0.131 1.000 1.000 307 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(12), ACACA(20), ACADL(4), ACADM(8), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), LDHA(10), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SDS(4), SUCLA2(5), SUCLG1(5), SUCLG2(1) 26690520 182 137 181 50 19 62 40 19 42 0 0.418 1.000 1.000 308 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(18), DUSP1(1), DUSP10(11), EEF2K(7), EIF4E(4), ELK1(3), GADD45A(2), HSPB1(1), IL1R1(2), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K10(4), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MKNK1(4), MKNK2(2), MYEF2(12), NFKB1(6), NR2C2(2), SRF(1), TRAF6(6) 26680683 180 137 178 47 16 76 36 13 39 0 0.177 1.000 1.000 309 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA2(2), ANXA3(6), ANXA4(5), ANXA5(6), ANXA6(8), CYP11A1(5), EDN1(1), EDNRA(3), EDNRB(16), HPGD(5), HSD11B1(9), PLA2G4A(21), PRL(3), PTGDR(8), PTGDS(4), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), PTGIS(12), PTGS1(18), PTGS2(12), S100A6(1), SCGB1A1(2), TBXAS1(11) 16642391 188 135 186 48 25 67 44 17 33 2 0.0756 1.000 1.000 310 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(9), ATM(53), BRCA1(22), CDKN1A(2), CHEK1(7), CHEK2(10), GADD45A(2), JUN(3), MAPK8(2), MDM2(5), MRE11A(13), NFKB1(6), NFKBIA(4), RAD50(10), RAD51(2), RBBP8(6), RELA(3), TP73(7) 23295621 166 134 162 31 17 47 37 23 40 2 0.0630 1.000 1.000 311 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), FADD(2), FAS(4), FASLG(10), GZMB(6), JUN(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MCL1(1), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), PARP1(4), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TNFSF10(3), TRADD(2), TRAF1(2), TRAF2(5) 29395614 178 133 178 64 13 75 40 19 31 0 0.869 1.000 1.000 312 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(26), AKT1(3), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), GNAS(29), GRB2(6), HRAS(2), MAPK1(2), MAPK14(4), MAPK3(3), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RPS6KA1(6), RPS6KA5(10), SOS1(17) 21506548 174 133 168 56 36 65 31 18 22 2 0.622 1.000 1.000 313 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), AGMAT(2), ALDH18A1(3), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), ASS1(5), CPS1(71), GATM(8), MAOA(5), MAOB(3), NAGS(1), ODC1(1), OTC(10), SAT1(3), SMS(3), SRM(2) 23626242 180 133 179 60 22 68 35 25 29 1 0.593 1.000 1.000 314 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(12), ACADM(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HIBCH(4), MLYCD(2), SMS(3), SRM(2), UPB1(2) 21711201 196 133 194 48 26 78 39 17 35 1 0.0425 1.000 1.000 315 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(8), CA1(6), CA12(2), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUL(6), HAL(5) 15322390 164 133 163 49 17 67 27 22 31 0 0.468 1.000 1.000 316 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), AOX1(22), BCAT1(3), BCKDHA(1), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), HIBADH(2), HMGCL(1), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), PCCA(6), PCCB(3), SDS(4) 28405135 180 133 179 55 16 61 45 22 36 0 0.666 1.000 1.000 317 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(2), AZIN1(4), BTG1(3), CBX3(4), CLOCK(4), CRY1(7), CRY2(6), DAZAP2(1), DNAJA1(3), EIF4G2(5), ETV6(5), GFRA1(20), GSTM3(2), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(11), NCKAP1(11), NCOA4(6), NR1D2(1), PER1(10), PER2(11), PPP1R3C(3), PPP2CB(3), PSMA4(2), PURA(2), SF3A3(2), SUMO3(5), TOB1(4), TUBB3(3), UGP2(4), VAPA(2), ZFR(10) 29207628 172 132 171 45 20 60 39 16 36 1 0.315 1.000 1.000 318 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), PRKCE(5), SOD1(1) 6364786 166 132 163 55 16 85 30 16 18 1 0.611 1.000 1.000 319 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), PON1(3) 23543387 188 132 188 72 25 72 38 23 30 0 0.818 1.000 1.000 320 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(17), DIAPH1(3), FYN(8), GSN(4), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PFN1(1), PIK3R1(4), PTK2(6), PXN(1), RAF1(6), ROCK1(19), SHC1(6), SRC(2), TLN1(15) 28343809 163 130 160 52 22 57 28 23 33 0 0.606 1.000 1.000 321 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(9), ATM(53), ATR(26), CCNA1(7), CCND1(3), CCNE1(7), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), DHFR(2), E2F1(3), GSK3B(4), HDAC1(4), SKP2(3), TFDP1(10), TGFB1(3), TGFB2(10) 21749566 164 130 160 34 18 52 31 21 40 2 0.0543 1.000 1.000 322 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(3), BLVRB(2), CP(11), CPOX(4), EPRS(27), FECH(4), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UROS(2) 22183495 181 130 180 51 9 88 47 12 25 0 0.356 1.000 1.000 323 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(5), EGF(13), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3) 26366328 159 128 153 45 21 44 29 24 41 0 0.513 1.000 1.000 324 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(7), GHR(19), GRB2(6), HRAS(2), INSR(10), IRS1(20), JAK2(16), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3R1(4), PLCG1(7), PRKCA(10), PTPN6(6), RAF1(6), RPS6KA1(6), SHC1(6), SLC2A4(4), SOS1(17), SRF(1), STAT5A(3), STAT5B(8) 24824509 173 128 168 51 29 59 37 22 26 0 0.299 1.000 1.000 325 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), GLCE(4), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), NDST1(6), NDST2(6), NDST3(16), NDST4(36) 16652374 172 128 170 49 31 58 41 23 17 2 0.217 1.000 1.000 326 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(17), ARHGEF1(5), GNA12(1), GNA13(6), GNAQ(5), GNB1(2), GNGT1(6), MYL2(8), MYLK(26), PLCB1(52), PPP1R12B(15), PRKCA(10), ROCK1(19) 16694901 172 128 171 40 18 73 28 20 33 0 0.0587 1.000 1.000 327 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(5), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MPL(5), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), THPO(7) 22394846 150 128 145 46 19 44 27 23 37 0 0.647 1.000 1.000 328 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(5), CHIT1(11), CMAS(10), CYB5R1(1), GFPT1(8), GFPT2(10), GNE(2), GNPDA1(2), GNPDA2(2), GNPNAT1(1), HEXA(6), HK1(12), HK2(11), HK3(22), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NAGK(6), NANS(2), NPL(4), PGM3(3), PHPT1(1), RENBP(7), UAP1(7) 23026251 161 127 160 42 29 63 26 19 24 0 0.100 1.000 1.000 329 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), BCL2(5), BCL2L1(3), CBL(10), CFLAR(2), CRKL(4), E2F1(3), FOS(3), GRB2(6), HRAS(2), IL2RA(6), IL2RB(7), IL2RG(5), IRS1(20), JAK1(11), JAK3(10), MAPK1(2), MAPK3(3), MYC(4), NMI(2), PIK3R1(4), PTPN6(6), RAF1(6), RPS6KB1(3), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5) 27177136 169 127 164 59 28 54 43 20 24 0 0.746 1.000 1.000 330 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(33), AXIN1(7), CREBBP(30), DVL1(5), EP300(11), FZD1(6), GSK3B(4), HDAC1(4), LDB1(3), LEF1(12), PITX2(8), TRRAP(51), WNT1(6) 25309528 180 127 178 40 40 52 37 15 36 0 0.0239 1.000 1.000 331 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(3), CALM2(1), CRKL(4), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), PAK1(9), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6) 22790036 154 127 147 48 24 53 30 12 35 0 0.575 1.000 1.000 332 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME3(8), PGK1(4), PGK2(27), PKLR(16), RPE(3), RPIA(8), TKT(3), TKTL1(14), TKTL2(26), TPI1(9) 16185365 159 126 159 34 18 62 33 18 28 0 0.00969 1.000 1.000 333 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), FADD(2), IKBKB(9), IL1A(4), IL1R1(2), IRAK1(6), MAP3K1(7), MAP3K7(10), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TLR4(64), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF6(6) 19518685 154 126 153 48 5 65 34 19 31 0 0.602 1.000 1.000 334 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(3), AKT2(7), AKT3(7), BCL2(5), GRB2(6), GSK3A(1), GSK3B(4), IL4R(10), IRS1(20), JAK1(11), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(6), PIK3CD(4), PIK3R1(4), PPP1R13B(7), RAF1(6), SHC1(6), SOS1(17), SOS2(13), STAT6(2) 26813232 166 125 161 62 24 61 37 17 27 0 0.871 1.000 1.000 335 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(10), EGF(13), GRB2(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), PTPRB(50), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), SRC(2) 18022937 159 124 153 50 17 54 36 18 34 0 0.774 1.000 1.000 336 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(25), DLG4(7), EPHB2(10), F2(9), F2RL1(2), F2RL2(12), F2RL3(2), JUN(3), MAP2K5(4), MAPK1(2), MAPK7(7), MAPK8(2), MYEF2(12), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RAF1(6), RASAL1(10), SRC(2), TEC(12), VAV1(8) 21952267 171 124 169 38 21 70 41 8 31 0 0.0142 1.000 1.000 337 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(7), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), GCK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), KHK(3), MPI(4), PFKFB1(10), PFKFB3(7), PFKFB4(6), PFKM(7), PFKP(5), PMM1(3), PMM2(1), SORD(2), TPI1(9) 19170829 158 122 158 38 33 55 30 13 27 0 0.0156 1.000 1.000 338 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(3), DAB1(34), FYN(8), LRP8(6), RELN(104), VLDLR(5) 11327920 163 122 162 50 17 62 41 14 29 0 0.623 1.000 1.000 339 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 CDK5(3), CDK5R1(3), CSNK1D(7), DRD1(13), GRM1(48), PLCB1(52), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 11231975 154 121 153 36 20 69 30 11 23 1 0.0301 1.000 1.000 340 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C9(20), MASP1(13), MASP2(8), MBL2(13) 15898744 156 121 155 56 18 69 24 16 28 1 0.787 1.000 1.000 341 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(9), F2R(10), F3(3), F5(40), F7(10), FGA(20), FGB(18), FGG(4), PROC(4), PROS1(30), SERPINC1(5), TFPI(4) 13160754 162 121 160 41 13 81 26 11 31 0 0.197 1.000 1.000 342 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(29), F2(9), F2R(10), FGA(20), FGB(18), FGG(4), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14) 10835018 168 121 163 47 14 86 33 9 26 0 0.331 1.000 1.000 343 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(2), DLAT(10), DLD(9), DLST(5), FH(13), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), PC(9), PDHA1(5), PDHA2(29), PDHX(4), PDK1(6), PDK2(3), PDK3(5), PDK4(2), PDP2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 22875222 160 121 159 51 23 63 23 22 29 0 0.499 1.000 1.000 344 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), ESCO1(10), ESCO2(4), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), NAT6(1), PNPLA3(4), PRDX6(5), TAT(9), TPO(33) 27575749 161 120 160 67 31 53 31 20 26 0 0.947 1.000 1.000 345 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(14), ABCC2(11), ABCG2(14), BCHE(35), CES1(8), CYP3A4(4), CYP3A5(5), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7) 18509913 153 119 152 56 12 69 36 16 20 0 0.788 1.000 1.000 346 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(33), AXIN1(7), BTRC(12), CCND1(3), CREBBP(30), CSNK1A1(2), CSNK1D(7), CSNK2A1(5), CTBP1(2), DVL1(5), FZD1(6), GSK3B(4), HDAC1(4), MAP3K7(10), MYC(4), NLK(3), PPARD(6), PPP2CA(1), TLE1(5), WIF1(3), WNT1(6) 22115751 158 119 156 33 28 55 29 14 32 0 0.0274 1.000 1.000 347 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C8B(20), C9(20), MASP1(13) 15531892 155 118 154 52 17 68 24 19 26 1 0.636 1.000 1.000 348 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(6), ARSD(6), ARSE(5), ASAH1(3), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SMPD1(3), SPTLC1(3), SPTLC2(3), UGCG(2) 19347418 151 118 150 44 24 74 28 8 17 0 0.156 1.000 1.000 349 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), NAGLU(5), SPAM1(25) 16293964 144 118 143 48 17 67 20 22 18 0 0.524 1.000 1.000 350 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AGPS(6), CHPT1(3), ENPP2(19), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PPAP2A(2), PPAP2B(3), PPAP2C(1) 18600534 156 118 155 38 17 65 29 11 34 0 0.0545 1.000 1.000 351 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), SELL(9), SELP(29) 11861905 149 118 147 49 11 75 32 11 20 0 0.669 1.000 1.000 352 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1C4(4), AKR1D1(12), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), SOAT2(2), SRD5A1(4) 18668477 161 117 158 45 12 66 37 19 27 0 0.233 1.000 1.000 353 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), GHR(19), IRS1(20), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(4), PABPC1(5), PDK2(3), PDPK1(3), PIK3R1(4), PRKCA(10), PTEN(11), RPS6KB1(3) 20961304 151 117 149 48 16 61 35 13 26 0 0.677 1.000 1.000 354 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG3(5), ATG5(3), ATG7(6), BECN1(1), GABARAPL1(1), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNG(7), PIK3C3(14), PIK3R4(22), PRKAA1(6), PRKAA2(8), ULK1(8), ULK2(9), ULK3(2) 16463835 148 117 146 33 11 72 32 13 19 1 0.0957 1.000 1.000 355 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(12), ADSL(2), ADSS(6), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), CAD(25), DARS(3), DDO(5), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), PC(9) 20822772 156 116 156 48 22 56 27 18 32 1 0.352 1.000 1.000 356 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(9), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(2), CXCR3(3), EGF(13), HRAS(2), ITGA1(14), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTK2(6), PXN(1), TLN1(15) 24158179 142 116 141 54 17 56 30 16 22 1 0.890 1.000 1.000 357 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), CASP3(5), CASP6(3), CASP7(3), CASP9(6), CYCS(2), PRKCA(10), PTK2(6), PXN(1), STAT1(7), TLN1(15) 21388156 137 115 134 41 12 48 24 19 32 2 0.677 1.000 1.000 358 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(3), BCL2(5), BCR(11), CRKL(4), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), MYC(4), PIK3R1(4), RAF1(6), SOS1(17), STAT1(7), STAT5A(3), STAT5B(8) 20782269 132 115 126 34 15 39 34 18 26 0 0.213 1.000 1.000 359 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(9), ADCY1(26), CCNB1(2), CDC25C(8), GNAI1(10), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), MAPK1(2), MAPK3(3), MYT1(24), PIN1(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RPS6KA1(6), SRC(2) 16355330 156 114 153 50 33 60 27 10 24 2 0.397 1.000 1.000 360 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(7), CREBBP(30), DUSP1(1), EP300(11), IKBKB(9), IL1B(1), MAP2K3(13), MAP2K6(5), MAP3K7(10), MAPK14(4), MYD88(1), NFKB1(6), NFKBIA(4), NR3C1(8), RELA(3), TGFBR1(7), TGFBR2(7), TLR2(10), TNF(2) 23832807 139 114 138 43 12 48 29 12 38 0 0.643 1.000 1.000 361 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TAT(9), TPO(33) 17678811 149 114 148 62 30 49 28 20 22 0 0.855 1.000 1.000 362 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(33), ASAH1(3), CAMP(4), CASP3(5), CERK(4), CREB1(2), CREB5(18), CXCL2(1), DAG1(3), EPHB2(10), FOS(3), GNAQ(5), ITPKA(2), ITPKB(7), JUN(3), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8) 22589372 149 114 148 33 21 49 30 9 40 0 0.0495 1.000 1.000 363 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(10), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), GAS2(10), LMNA(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), SPTAN1(21), TNFRSF10B(3), TNFRSF25(2), TNFSF10(3), TNFSF12(1), TRADD(2), TRAF2(5) 26779656 146 113 146 53 8 51 38 16 33 0 0.935 1.000 1.000 364 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(12), BAIAP2(3), CASP1(8), CASP3(5), CASP7(3), CASP8(6), GAPDH(5), INSR(10), ITCH(8), MAGI1(21), MAGI2(33), RERE(12), WWP1(13), WWP2(7) 19234129 146 113 145 42 16 63 21 14 32 0 0.436 1.000 1.000 365 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 BCL2(5), CREBBP(30), EP300(11), FYN(8), IL2RG(5), IL7(2), IL7R(21), JAK1(11), JAK3(10), LCK(9), NMI(2), PIK3R1(4), PTK2B(14), STAT5A(3), STAT5B(8) 20682222 143 113 143 47 22 45 29 16 31 0 0.608 1.000 1.000 366 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(9), ACTN1(7), ACTN2(43), CAPN1(2), CAPNS1(1), CAPNS2(2), ITGA1(14), ITGB1(6), ITGB3(13), PTK2(6), PXN(1), SPTAN1(21), SRC(2), TLN1(15) 22874847 142 113 141 56 15 52 38 19 18 0 0.906 1.000 1.000 367 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(7), ACTN2(43), BCAR1(3), CSK(2), CTNNA1(9), CTNNA2(65), PTK2(6), PXN(1), SRC(2), VCL(8) 13941488 146 112 145 51 19 58 30 17 22 0 0.571 1.000 1.000 368 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(15), ACE2(9), AGT(4), AGTR1(9), AGTR2(6), ANPEP(10), CMA1(8), CPA3(16), CTSA(4), CTSG(12), ENPEP(18), LNPEP(5), MAS1(5), MME(20), NLN(7), REN(6), THOP1(8) 16967000 162 112 161 62 21 71 28 18 23 1 0.765 1.000 1.000 369 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(2), IFNB1(7), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL1RN(3), IL6(2), IRAK1(6), IRAK2(6), IRAK3(6), JUN(3), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), TGFB1(3), TGFB2(10), TNF(2), TOLLIP(2), TRAF6(6) 23848641 140 112 139 51 6 50 30 17 37 0 0.928 1.000 1.000 370 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL6(2), IL6R(8), IL6ST(3), JAK1(11), JAK2(16), JAK3(10), JUN(3), MAP2K1(10), MAPK3(3), PTPN11(9), RAF1(6), SHC1(6), SOS1(17), SRF(1), STAT3(11) 18997736 135 112 130 35 16 37 32 24 26 0 0.271 1.000 1.000 371 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(1), CREB1(2), CREB5(18), DUSP4(2), DUSP6(4), DUSP9(6), EEF2K(7), EIF4E(4), GRB2(6), MAP2K1(10), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MOS(9), NFKB1(6), RAP1A(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), SHC1(6), SOS1(17), SOS2(13), TRAF3(4) 22404326 152 112 149 41 20 60 33 14 25 0 0.229 1.000 1.000 372 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(33), CDH1(6), CREBBP(30), EP300(11), MAP2K1(10), MAP3K7(10), MAPK3(3), SKIL(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7) 20740652 141 112 138 25 14 50 28 14 35 0 0.0268 1.000 1.000 373 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(34), CR2(20), FCGR2B(7), HLA-DRA(3), HLA-DRB1(5), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41) 12281228 149 111 144 48 11 63 28 10 37 0 0.776 1.000 1.000 374 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(4), ALDOB(8), ALDOC(2), DERA(4), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKL(9), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TALDO1(1), TKT(3), TKTL1(14), TKTL2(26) 19391436 135 111 135 36 16 44 31 17 27 0 0.149 1.000 1.000 375 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13) 16216807 127 111 126 43 21 60 22 9 15 0 0.461 1.000 1.000 376 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(10), ALOX15(5), ALOX5(10), CYP1A2(3), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), HSD3B7(7), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 19242354 152 111 151 62 17 66 37 15 17 0 0.905 1.000 1.000 377 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(9), GLB1(3), HEXA(6), LCT(50), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(3), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12) 13265083 131 111 130 49 24 47 27 12 21 0 0.684 1.000 1.000 378 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(4), DARS(3), EPRS(27), FARS2(5), GARS(3), HARS(5), IARS(9), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), NARS(4), QARS(6), RARS(6), SARS(5), TARS(14), WARS(6), WARS2(7), YARS(3) 25898121 153 110 153 38 12 59 35 18 29 0 0.232 1.000 1.000 379 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2H1(4), GTF2H4(1), ILK(1), MNAT1(2), POLR1A(13), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3B(20), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(2), TAF5(5), TAF6(3), TAF7(3), TAF9(3), TBP(1) 28239498 137 108 137 47 22 40 39 14 21 1 0.865 1.000 1.000 380 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(5), GLI2(28), GLI3(39), GSK3B(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SHH(2), SMO(17), SUFU(2) 13336116 129 108 127 38 34 45 25 7 17 1 0.222 1.000 1.000 381 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IGF1(4), IGF1R(8), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1) 18229048 123 107 118 37 17 40 23 15 28 0 0.511 1.000 1.000 382 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(4), CHAT(22), COMT(1), DBH(12), DDC(8), GAD1(7), GAD2(27), HDC(16), MAOA(5), PAH(11), PNMT(1), SLC18A3(19), TH(7), TPH1(8) 11438375 149 106 148 53 23 60 25 10 31 0 0.592 1.000 1.000 383 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL2(7), IL2RA(6), IL2RB(7), IL2RG(5), JAK1(11), JAK3(10), JUN(3), LCK(9), MAP2K1(10), MAPK3(3), MAPK8(2), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5) 18686649 137 106 132 38 16 46 29 20 26 0 0.283 1.000 1.000 384 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(6), GALNT10(6), GALNT2(11), GALNT3(12), GALNT4(4), GALNT6(5), GALNT7(9), GALNT8(19), GCNT1(8), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(33) 11655898 125 106 124 62 15 50 31 15 14 0 0.998 1.000 1.000 385 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CBL(10), CSF1R(18), EGF(13), GRB2(6), MET(22), PDGFRA(41), PRKCA(10), SH3GLB2(1), SH3KBP1(7), SRC(2) 13545663 130 105 126 42 15 44 26 14 30 1 0.702 1.000 1.000 386 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(22), BST1(3), CD38(4), ENPP1(14), ENPP3(19), NADK(3), NADSYN1(2), NMNAT1(3), NMNAT2(8), NMNAT3(1), NNMT(7), NNT(11), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT12(7), QPRT(2) 17307368 140 105 138 41 15 50 21 21 33 0 0.457 1.000 1.000 387 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), INSR(10), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SLC2A4(4), SOS1(17), SRF(1) 18750941 125 105 120 42 19 36 26 18 26 0 0.707 1.000 1.000 388 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(2), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CD28(4), CD4(8), CXCR3(3), CXCR4(6), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL4(1), IL4R(10), IL5(2), TGFB1(3), TGFB2(10) 16147480 131 105 131 33 14 53 21 13 29 1 0.0856 1.000 1.000 389 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(17), APOA1(3), APOA4(12), APOC1(2), APOC2(2), APOC3(2), APOE(1), CETP(8), CYP7A1(8), DGAT1(1), HMGCR(5), LCAT(6), LDLR(9), LIPC(9), LPL(8), LRP1(36), SCARB1(4), SOAT1(8) 21987629 141 105 137 53 21 50 25 19 25 1 0.832 1.000 1.000 390 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(3), CABIN1(10), CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), HDAC5(5), IGF1(4), IGF1R(8), INSR(10), MAP2K6(5), MAPK14(4), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), NFATC1(9), NFATC2(15), PIK3R1(4), PPP3CB(3), PPP3CC(3), SYT1(6), YWHAH(1) 25110486 125 103 124 49 18 49 18 10 30 0 0.731 1.000 1.000 391 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28) 14237894 131 103 130 40 6 59 35 13 18 0 0.514 1.000 1.000 392 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 DUSP1(1), GORASP1(2), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK5(5), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PIK3CD(4), PIK3R1(4), SYT1(6), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6) 24607286 119 103 119 49 19 35 21 13 31 0 0.890 1.000 1.000 393 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(18), DDX20(4), E2F1(3), E2F4(5), ETS1(8), ETS2(6), ETV3(2), FOS(3), HDAC2(8), HDAC5(5), HRAS(2), JUN(3), NCOR2(30), RBL1(7), RBL2(5), SIN3A(12), SIN3B(2) 20506999 124 102 124 43 15 35 33 17 24 0 0.770 1.000 1.000 394 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(11), ASPA(5), CNDP1(10), DDC(8), HAL(5), HARS(5), HDC(16), MAOA(5), MAOB(3), PRPS1(3), PRPS2(4) 19703306 136 102 136 40 25 46 24 18 23 0 0.194 1.000 1.000 395 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A1(2), EIF4A2(7), EIF4B(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), MKNK1(4), PDK2(3), PDPK1(3), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3), TSC1(10), TSC2(13) 20287773 122 102 120 37 12 39 32 11 28 0 0.612 1.000 1.000 396 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(8), GTF2F1(4), HDAC3(3), NCOA1(18), NCOA2(22), NCOA3(14), NCOR2(30), POLR2A(11), RARA(7), RXRA(1), TBP(1) 19823020 128 102 128 39 17 43 33 19 16 0 0.510 1.000 1.000 397 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(2), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), ILVBL(3), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCDC(2), PPCS(1), UPB1(2), VNN1(10) 13820415 127 101 124 34 14 59 18 15 20 1 0.220 1.000 1.000 398 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13) 13180834 115 101 114 36 18 57 20 7 13 0 0.333 1.000 1.000 399 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), GATM(8), GLUD1(4), NAGS(1), OAT(3), ODC1(1), OTC(10), PYCR1(1), SMS(3) 13907447 122 101 121 44 12 47 22 18 22 1 0.811 1.000 1.000 400 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CALM1(3), CALM2(1), CHUK(7), EGR2(4), EGR3(1), GNAQ(5), MAP3K1(7), MYC(4), NFATC1(9), NFATC2(15), NFKB1(6), NFKBIA(4), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(6), VIP(6), VIPR2(3) 21571023 121 101 121 41 17 49 20 12 22 1 0.610 1.000 1.000 401 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C9(20) 12861381 122 100 122 45 15 49 21 15 21 1 0.839 1.000 1.000 402 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(3), CRK(1), CXCL12(3), CXCR4(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(19), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PTK2B(14), PXN(1), RAF1(6), RELA(3) 20314865 129 100 126 38 18 53 23 11 24 0 0.305 1.000 1.000 403 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(4), CBS(1), CTH(2), GGT1(1), LCMT1(5), LCMT2(7), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(5), PAPSS2(10), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SCLY(4), SEPHS1(4), SEPHS2(2), WBSCR22(3) 20010499 124 100 122 50 22 40 27 13 22 0 0.884 1.000 1.000 404 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(45), ABCB11(28), ABCB4(19), ABCC1(14), ABCC3(13), GSTP1(2) 11611517 121 99 120 35 11 48 27 11 24 0 0.309 1.000 1.000 405 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), GSR(5), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), OPLAH(10), TXNDC12(2) 17465013 126 98 127 21 15 49 19 10 33 0 0.000431 1.000 1.000 406 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(13), CHUK(7), CRADD(3), IKBKB(9), JUN(3), LTA(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP4K2(4), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNF(2), TRADD(2), TRAF2(5) 19246618 118 98 118 41 9 43 26 10 30 0 0.777 1.000 1.000 407 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(2), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(1), MTR(22), SRM(2), TAT(9) 16605481 120 97 120 40 18 44 22 11 25 0 0.623 1.000 1.000 408 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(26), AKT1(3), BAX(3), BCL2(5), BCL2L1(3), CSF2RB(14), IGF1(4), IGF1R(8), IL3(4), IL3RA(8), KIT(12), KITLG(6), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), YWHAH(1) 15840925 125 96 124 51 14 52 29 9 19 2 0.870 1.000 1.000 409 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), ACO2(3), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), PC(9), PCK1(21), SDHA(8), SDHB(1), SUCLA2(5), SUCLG1(5), SUCLG2(1) 16611796 111 96 110 46 18 38 12 18 25 0 0.898 1.000 1.000 410 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(5), B3GAT2(10), CHPF(10), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST3(1), CHST7(2), CHSY1(5), DSE(19), UST(5), XYLT1(44), XYLT2(3) 11111541 117 96 115 48 29 31 28 12 17 0 0.774 1.000 1.000 411 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(26), CREM(3), FHL5(15), FSHB(4), FSHR(37), GNAS(29), XPO1(12) 7620498 126 95 122 42 24 54 23 10 14 1 0.784 1.000 1.000 412 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(5), ELK1(3), EPO(6), EPOR(2), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PLCG1(7), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8) 17270267 114 95 109 24 19 34 26 15 20 0 0.0459 1.000 1.000 413 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CYP2C19(13), CYP2C9(8), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1) 24862284 115 95 114 35 13 42 28 13 19 0 0.567 1.000 1.000 414 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCS(1), UPB1(2) 11120123 110 93 107 31 10 51 16 13 19 1 0.410 1.000 1.000 415 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TPO(33), TYR(29) 7742906 110 93 109 43 18 40 24 12 16 0 0.774 1.000 1.000 416 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(3), CALM2(1), CDKN1A(2), GNAQ(5), MARCKS(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), SP1(6), SP3(6), SYT1(6) 15924463 104 92 104 38 17 45 18 6 18 0 0.684 1.000 1.000 417 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(3), GRB2(6), HRAS(2), IL3(4), IL3RA(8), JAK2(16), MAP2K1(10), MAPK3(3), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8) 14173710 112 92 107 27 17 38 28 15 14 0 0.103 1.000 1.000 418 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(8), APC(33), AXIN1(7), BTRC(12), DLL1(5), DVL1(5), FZD1(6), GSK3B(4), NOTCH1(26), PSEN1(6), WNT1(6) 15330327 118 92 117 26 28 35 19 11 25 0 0.0505 1.000 1.000 419 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(4), AP2M1(5), ARF1(1), BTK(25), EEA1(5), GSK3A(1), GSK3B(4), LYN(6), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(8) 19805791 107 91 106 27 12 31 28 12 23 1 0.225 1.000 1.000 420 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(4), CASP3(5), CASP8(6), CFLAR(2), FADD(2), JUN(3), MAP2K4(8), MAP3K3(10), MAP3K7(10), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR2C2(2), RALBP1(3), RIPK1(11), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF2(5) 21702517 106 91 105 33 9 40 24 7 26 0 0.621 1.000 1.000 421 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(10), PGAP1(8), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGW(2), PIGX(4), PIGZ(3) 19033646 112 89 111 49 13 38 27 15 19 0 0.961 1.000 1.000 422 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 18 AMPH(24), AP2A1(4), AP2M1(5), BIN1(4), CALM1(3), CALM2(1), DNM1(11), EPN1(11), EPS15(7), PICALM(6), PPP3CB(3), PPP3CC(3), SYNJ1(14), SYNJ2(9), SYT1(6) 16457473 111 89 110 39 13 41 24 9 24 0 0.863 1.000 1.000 423 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(26), ADRB2(4), GNAS(29), PLCE1(28), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAP2B(2) 11785893 113 89 109 38 27 44 17 8 14 3 0.570 1.000 1.000 424 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(3), BCL2(5), IGF1R(8), MYC(4), POLR2A(11), PPP2CA(1), PRKCA(10), TEP1(39), TERF1(4), TERT(7), TNKS(11), XRCC5(9) 18483160 112 89 111 42 17 44 20 8 23 0 0.665 1.000 1.000 425 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15) 7379109 110 88 109 40 12 42 26 13 16 1 0.596 1.000 1.000 426 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PPP2CA(1), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 12237886 111 88 108 38 26 39 24 7 13 2 0.751 1.000 1.000 427 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15) 7379109 110 88 109 40 12 42 26 13 16 1 0.596 1.000 1.000 428 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), PON1(3), PON2(2), PON3(5) 14444794 103 88 103 43 5 40 22 15 21 0 0.919 1.000 1.000 429 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), ZNRD1(1) 18917469 107 87 107 34 16 35 31 9 16 0 0.696 1.000 1.000 430 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(1), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), DDOST(1), DPAGT1(5), DPM1(5), FUT8(7), MAN1A1(3), MAN1B1(4), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), RPN1(3), RPN2(4), ST6GAL1(4) 15889813 104 87 104 30 19 44 14 11 16 0 0.214 1.000 1.000 431 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD28(4), CD3D(2), CD3E(2), CD4(8), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6) 9079402 105 87 105 36 11 39 24 5 26 0 0.679 1.000 1.000 432 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(14), AMT(1), ATIC(7), DHFR(2), FTCD(8), GART(9), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3) 15191954 99 86 98 25 14 40 12 7 26 0 0.150 1.000 1.000 433 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(6), IL22(4), IL22RA1(7), IL22RA2(6), JAK1(11), JAK2(16), JAK3(10), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), TYK2(5) 14605481 94 86 94 28 8 24 21 18 23 0 0.584 1.000 1.000 434 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(8), JAK1(11), JAK2(16), JAK3(10), PIAS3(7), PTPRU(19), REG1A(20), SRC(2), STAT3(11) 12181194 107 86 105 32 12 36 21 14 24 0 0.368 1.000 1.000 435 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(10), CHUK(7), IFNG(7), IKBKB(9), IL2(7), IL4(1), JUN(3), MAP3K1(7), MAP3K5(14), MAP4K5(2), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), TNFRSF9(7), TNFSF9(3), TRAF2(5) 15554068 101 85 101 29 7 32 18 10 33 1 0.652 1.000 1.000 436 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(32), MAP2(49), PPP1CA(2), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2), PRKCE(5) 14641764 108 85 107 27 9 42 27 14 14 2 0.525 1.000 1.000 437 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(10), GCK(6), GFPT1(8), GNE(2), GNPDA1(2), GNPDA2(2), HEXA(6), HK1(12), HK2(11), HK3(22), PGM3(3), RENBP(7), UAP1(7) 13601954 98 85 98 32 23 36 13 11 15 0 0.469 1.000 1.000 438 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(10), ARHGDIB(2), BIRC2(2), BIRC3(4), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), GZMB(6), LMNA(2), LMNB1(5), LMNB2(5), PRF1(8) 15507295 110 85 109 32 4 45 24 13 24 0 0.585 1.000 1.000 439 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(15), CNR2(3), DNMT1(8), MTNR1A(15), MTNR1B(13), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), TBXA2R(1) 8843339 97 85 96 38 20 31 19 13 13 1 0.599 1.000 1.000 440 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTR(22) 13939418 104 84 104 33 13 37 20 11 23 0 0.506 1.000 1.000 441 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), KLK2(10), MAP2K1(10), MAPK3(3), MAPK8(2), NGFR(5), PIK3R1(4), PLCG1(7), RAF1(6), SHC1(6), SOS1(17) 13628895 92 84 87 25 12 32 21 11 16 0 0.331 1.000 1.000 442 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), NCK1(5), NCKAP1(11), NTRK1(14), PIR(4), PSMA7(5), WASF1(10), WASF2(3), WASF3(13), WASL(7) 12318169 99 83 97 35 13 30 22 10 23 1 0.848 1.000 1.000 443 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(18), AGT(4), AGTR2(6), EDN1(1), EDNRA(3), EDNRB(16), EGF(13), FOS(3), HRAS(2), JUN(3), MYC(4), NFKB1(6), PLCG1(7), PRKCA(10), RELA(3) 14455764 99 83 98 33 14 34 22 12 17 0 0.677 1.000 1.000 444 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(5), CASP8(6), CYCS(2), FADD(2), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(10), RAF1(6), RELA(3), RIPK1(11), SMPD1(3), TRADD(2), TRAF2(5) 16473660 96 83 93 32 11 33 27 11 14 0 0.654 1.000 1.000 445 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3D(2), CD3E(2), CXCR3(3), ETV5(6), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), JAK2(16), JUN(3), MAP2K6(5), MAPK14(4), MAPK8(2), STAT4(11), TYK2(5) 14944366 107 83 107 25 10 35 21 12 28 1 0.163 1.000 1.000 446 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(10), CALM1(3), CALM2(1), CAPN2(5), CAPNS1(1), CAPNS2(2), EP300(11), HDAC1(4), HDAC2(8), MEF2D(4), NFATC1(9), NFATC2(15), PPP3CB(3), PPP3CC(3), PRKCA(10), SYT1(6) 18692549 95 83 95 40 19 35 12 7 22 0 0.879 1.000 1.000 447 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(4), CAT(3), EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33) 9442451 94 83 92 38 18 32 18 12 14 0 0.781 1.000 1.000 448 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(14), AMT(1), ATIC(7), ATP6V0C(4), DHFR(2), GART(9), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3) 14411684 94 83 92 22 14 36 11 8 25 0 0.0868 1.000 1.000 449 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(2), IFNG(7), IFNGR1(7), IFNGR2(4), IKBKB(9), JAK2(16), LIN7A(7), NFKB1(6), NFKBIA(4), RELA(3), TNF(2), TNFRSF1B(2), USH1C(13), WT1(16) 12486516 98 83 97 32 12 34 19 7 25 1 0.610 1.000 1.000 450 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36) 13406889 100 82 99 30 14 39 25 10 12 0 0.487 1.000 1.000 451 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELL(9) 8750494 96 82 94 29 6 48 20 8 14 0 0.600 1.000 1.000 452 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(22), CD38(4), ENPP1(14), ENPP3(19), NADSYN1(2), NMNAT1(3), NMNAT2(8), NNMT(7), NNT(11), NT5E(5), NT5M(3), QPRT(2) 11710641 100 82 98 32 11 39 11 18 21 0 0.605 1.000 1.000 453 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD28(4), CD3D(2), CD3E(2), CD8A(4), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6) 8651043 101 82 101 38 12 35 25 4 25 0 0.828 1.000 1.000 454 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(4), CD86(11), HLA-DRA(3), HLA-DRB1(5), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL2RA(6), IL4(1), IL4R(10) 10203446 102 82 98 30 10 38 15 7 31 1 0.557 1.000 1.000 455 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(26), ADRB2(4), CFTR(11), GNAS(29), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(1) 10408581 95 81 92 33 24 37 15 6 10 3 0.691 1.000 1.000 456 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 HLA-A(8), ITGB1(6), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LAT(4), MAP2K1(10), MAPK3(3), PAK1(9), PIK3R1(4), PTK2B(14), PTPN6(6), SYK(5), VAV1(8) 13008052 93 81 89 26 21 30 10 9 23 0 0.251 1.000 1.000 457 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(30), EP300(11), LPL(8), NCOA1(18), NCOA2(22), PPARG(8), RXRA(1) 14903897 98 81 98 19 14 34 21 11 18 0 0.0377 1.000 1.000 458 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(12), KHK(3), LCT(50), MPI(4), PGM1(3), PYGL(6), PYGM(9), TPI1(9), TREH(1) 10753455 97 80 96 27 15 44 23 5 10 0 0.133 1.000 1.000 459 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 65 MRPL13(3), MRPS7(3), RPL10A(2), RPL11(2), RPL13A(2), RPL14(2), RPL19(2), RPL21(1), RPL22L1(3), RPL23A(2), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL36A(2), RPL36AL(1), RPL37(2), RPL3L(8), RPL41(1), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPS10(3), RPS11(1), RPS13(1), RPS18(2), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS7(1), RPSA(1) 17333526 93 80 91 30 16 31 17 8 21 0 0.606 1.000 1.000 460 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(3), AKT2(7), AKT3(7), BPNT1(7), GRB2(6), ILK(1), MAPK1(2), MAPK3(3), PDK1(6), PIK3CD(4), PTEN(11), PTK2B(14), RBL2(5), SHC1(6), SOS1(17) 14585402 99 80 96 33 13 39 24 9 14 0 0.690 1.000 1.000 461 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(13), C5(6), C6(29), C8A(18), C9(20) 8883651 86 79 86 33 11 34 17 7 16 1 0.903 1.000 1.000 462 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), IDS(7), IDUA(1), LCT(50), NAGLU(5) 11432703 87 78 86 30 13 43 10 9 12 0 0.536 1.000 1.000 463 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(3), GRB2(6), HRAS(2), IGF1R(8), IRS1(20), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3R1(4), RAF1(6), SHC1(6), SOS1(17), YWHAH(1) 13516061 88 78 82 26 13 33 18 10 14 0 0.423 1.000 1.000 464 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREB1(2), CREBBP(30), EP300(11), NCOA3(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RARA(7), RXRA(1) 16607315 93 77 93 21 14 37 20 8 13 1 0.114 1.000 1.000 465 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(2), IARS(9), IARS2(15), ILVBL(3), LARS(14), LARS2(2), PDHA1(5), PDHA2(29), VARS(10), VARS2(2) 14999013 94 77 93 26 12 35 15 11 21 0 0.334 1.000 1.000 466 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TAL1(7), TALDO1(1), TKT(3) 16397956 89 77 89 26 12 27 19 13 18 0 0.327 1.000 1.000 467 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(30), DAXX(8), HRAS(2), PAX3(10), PML(12), RARA(7), SIRT1(2), SP100(18), TNF(2), TNFRSF1B(2) 13175932 93 77 93 17 16 32 24 8 13 0 0.0194 1.000 1.000 468 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(7), AKT3(7), CDKN1A(2), ELK1(3), GRB2(6), HRAS(2), MAP2K1(10), MAP2K2(1), NGFR(5), NTRK1(14), PIK3CD(4), SHC1(6), SOS1(17) 11082729 87 77 82 26 11 35 22 9 9 1 0.385 1.000 1.000 469 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(4), AKT1(3), ANXA1(1), CALM1(3), CALM2(1), GNAS(29), GNB1(2), GNGT1(6), NFKB1(6), NOS3(12), NPPA(3), NR3C1(8), PIK3R1(4), RELA(3), SYT1(6) 12457063 91 76 87 26 17 34 16 5 19 0 0.362 1.000 1.000 470 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), PGD(2) 14510190 93 76 93 16 11 36 12 7 27 0 0.00372 1.000 1.000 471 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4) 20146303 95 76 92 30 6 39 20 8 22 0 0.648 1.000 1.000 472 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(7), CREBBP(30), EP300(11), FADD(2), HDAC3(3), IKBKB(9), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF6(6) 17978878 98 76 98 32 11 30 23 11 23 0 0.666 1.000 1.000 473 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD3E(2), CD4(8), FYN(8), HLA-DRA(3), HLA-DRB1(5), LCK(9), PTPRC(41), ZAP70(9) 7299922 87 76 83 27 10 28 15 5 29 0 0.690 1.000 1.000 474 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(4), CD3D(2), CD3E(2), CD80(3), CD86(11), CTLA4(3), GRB2(6), HLA-DRA(3), HLA-DRB1(5), ICOS(5), IL2(7), ITK(16), LCK(9), PIK3R1(4), PTPN11(9) 8593095 89 75 84 24 6 33 13 10 27 0 0.478 1.000 1.000 475 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(3), EPX(14), LPO(7), MPO(15), MTHFR(7), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33) 9328337 90 75 89 38 19 32 16 9 14 0 0.832 1.000 1.000 476 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(20), CPT1A(11), LEP(4), LEPR(26), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5) 11717314 84 75 83 28 9 29 23 6 17 0 0.796 1.000 1.000 477 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 22 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), HDAC5(5), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PPARA(4), PPP3CB(3), PPP3CC(3), SLC2A4(4), SYT1(6), YWHAH(1) 15291069 89 75 89 22 8 33 15 10 23 0 0.204 1.000 1.000 478 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(12), IL13(2), IL4(1), IL5(2), JUNB(1), MAF(3), MAP2K3(13), MAPK14(4), NFATC1(9), NFATC2(15), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 9567274 86 74 85 35 15 36 16 4 14 1 0.776 1.000 1.000 479 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(2), BNIP1(3), GOSR1(2), GOSR2(3), SNAP23(3), SNAP25(5), SNAP29(1), STX11(3), STX12(3), STX16(5), STX17(4), STX18(3), STX19(3), STX2(8), STX3(6), STX4(1), STX5(3), STX6(3), STX7(3), STX8(2), TSNARE1(8), USE1(2), VAMP3(1), VAMP4(2), VAMP5(1), VAMP7(4), VAMP8(1), VTI1A(2), VTI1B(1), YKT6(1) 13367893 89 74 89 26 7 28 20 12 22 0 0.501 1.000 1.000 480 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(4), CYP51A1(5), DHCR24(3), DHCR7(6), EBP(3), FDFT1(4), FDPS(5), GGCX(7), GGPS1(2), HMGCR(5), HSD17B7(3), IDI1(2), IDI2(1), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4), TM7SF2(6) 15429563 85 73 83 26 13 24 21 11 16 0 0.459 1.000 1.000 481 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3) 10651830 86 73 83 24 7 39 17 6 17 0 0.296 1.000 1.000 482 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(14), GBA(7), LPO(7), MPO(15), PRDX6(5), TPO(33) 6754499 81 73 80 38 16 28 15 9 13 0 0.939 1.000 1.000 483 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), BCL2L1(3), CASP9(6), CDC42(1), CHUK(7), ELK1(3), H2AFX(3), HRAS(2), MAP2K1(10), MAPK3(3), NFKB1(6), PIK3R1(4), RAF1(6), RALA(5), RALBP1(3), RALGDS(5), RELA(3), RHOA(4) 13475906 77 73 73 24 7 29 14 10 17 0 0.502 1.000 1.000 484 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), PAK1(9), PDGFRA(41), PIK3R1(4), WASL(7) 9049510 80 72 78 30 8 24 16 7 24 1 0.916 1.000 1.000 485 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GCNT2(5), ST3GAL6(6), ST8SIA1(6) 12770463 80 72 79 25 9 37 14 8 12 0 0.293 1.000 1.000 486 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(11), JAK2(16), JAK3(10), PIAS1(2), PIAS3(7), PTPRU(19), REG1A(20), SOAT1(8) 10944552 94 72 92 28 13 33 16 11 21 0 0.392 1.000 1.000 487 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3) 12061465 80 71 78 31 15 22 19 9 15 0 0.811 1.000 1.000 488 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(13), MAP2K1(10), MAP3K1(7), MAPK14(4), NCOR2(30), RARA(7), RXRA(1), THRA(5), THRB(4) 11512200 81 70 79 25 7 27 21 9 17 0 0.632 1.000 1.000 489 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(4), IFNB1(7), JAK1(11), PTPRU(19), REG1A(20), STAT1(7), STAT2(6), TYK2(5) 10025136 79 70 77 18 9 37 8 10 15 0 0.0398 1.000 1.000 490 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), LTA(3), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNFAIP3(6), TNFRSF1B(2), TRAF1(2), TRAF2(5), TRAF3(4) 18085983 79 70 79 33 8 25 21 9 16 0 0.954 1.000 1.000 491 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(3), GRB2(6), HRAS(2), KLK2(10), NTRK1(14), PIK3R1(4), PLCG1(7), PRKCA(10), SHC1(6), SOS1(17) 10778981 79 70 75 29 13 29 18 7 11 1 0.772 1.000 1.000 492 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(5), GNB1(2), GNGT1(6), HTR2C(8), PLCB1(52), TUB(11) 5767938 89 70 88 27 9 44 14 8 14 0 0.416 1.000 1.000 493 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(22), CHKA(4), PCYT1A(2), PDHA1(5), PDHA2(29), PEMT(2), SLC18A3(19) 5570894 87 69 86 35 18 38 15 3 13 0 0.756 1.000 1.000 494 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(4), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), CHST1(17), CHST2(14), CHST4(3), CHST6(7), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4) 9963065 85 69 84 41 14 31 21 6 13 0 0.950 1.000 1.000 495 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(4), PLCB1(52), PLCG1(7), PRKCA(10), VAV1(8) 8579464 84 69 82 22 10 39 13 6 16 0 0.185 1.000 1.000 496 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(20), ACACB(28), FASN(18), MCAT(3), OLAH(8), OXSM(5) 12381899 82 68 82 27 15 32 14 7 14 0 0.502 1.000 1.000 497 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(11), CES1(8), DDHD1(11), ESCO1(10), ESCO2(4), LIPA(2), NAT6(1), PLA1A(6), PNPLA3(4), PPME1(6), PRDX6(5) 20439259 79 68 79 24 12 24 17 13 13 0 0.565 1.000 1.000 498 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(9), APAF1(10), BCL2(5), CASP3(5), CASP9(6), CYCS(2), DAXX(8), FAS(4), FASLG(10), HSPB1(1), HSPB2(1), IL1A(4), MAPKAPK2(2), MAPKAPK3(3), TNF(2) 9129702 72 68 72 30 2 34 18 10 8 0 0.939 1.000 1.000 499 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(3), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), E2F1(3), HRAS(2), MAPK1(2), MAPK3(3), NFKB1(6), NFKBIA(4), PAK1(9), PIK3R1(4), RAF1(6), RELA(3), TFDP1(10) 13040149 81 68 75 26 10 28 15 5 23 0 0.567 1.000 1.000 500 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(7), ICAM1(2), ITGAL(26), ITGAM(24), ITGB2(8), SELL(9) 7363639 76 67 74 33 8 39 17 3 9 0 0.870 1.000 1.000 501 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), CREB1(2), GRB2(6), HRAS(2), MAPK1(2), MAPK3(3), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), NTRK1(14), PIK3R1(4), PLCG1(7), RPS6KA1(6), SHC1(6) 13443911 76 66 74 24 16 26 14 6 13 1 0.416 1.000 1.000 502 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), BCAR1(3), CDKN1B(5), GRB2(6), ILK(1), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(3), PIK3R1(4), PTEN(11), PTK2(6), SHC1(6), SOS1(17) 13693137 79 66 76 26 8 27 17 11 16 0 0.721 1.000 1.000 503 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(10), ARHGAP5(17), ARHGDIB(2), CASP1(8), CASP10(7), CASP3(5), CASP8(6), CASP9(6), CYCS(2), GZMB(6), JUN(3), PRF1(8) 10442703 80 65 80 26 3 35 16 14 12 0 0.786 1.000 1.000 504 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(6), IL2RG(5), IL4(1), IL4R(10), IRS1(20), JAK1(11), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(2) 11837408 77 65 76 28 15 28 14 11 9 0 0.700 1.000 1.000 505 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(8), ACADS(1), ACADVL(2), ACSL1(12), ACSL3(4), ACSL4(7), CPT1A(11), CPT2(3), EHHADH(13), HADHA(3), PECR(3), SCP2(4), SLC25A20(1) 13533556 76 64 75 17 11 23 13 13 16 0 0.144 1.000 1.000 506 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(48), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), YWHAH(1) 6195060 73 64 73 24 8 28 13 6 16 2 0.627 1.000 1.000 507 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(15), CD44(7), CSF1(1), FCGR3A(9), IL1B(1), IL6R(8), SELL(9), SPN(4), TGFB1(3), TGFB2(10), TNF(2), TNFRSF1B(2), TNFRSF8(11), TNFSF8(1) 10550242 83 64 81 28 8 40 15 6 14 0 0.407 1.000 1.000 508 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(8), ENO1(7), GPI(8), HK1(12), PFKL(9), PGAM1(1), PGK1(4), PKLR(16), TPI1(9) 7359403 74 63 74 24 13 24 19 5 13 0 0.418 1.000 1.000 509 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(12), GPR161(6), GPR171(2), GPR18(4), GPR34(5), GPR39(6), GPR45(14), GPR65(14), GPR68(1), GPR75(5) 7970124 74 63 73 23 9 29 23 4 9 0 0.376 1.000 1.000 510 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(3), CREB1(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(6), PIK3R1(4), RELA(3), SP1(6) 12428527 69 63 67 24 3 25 15 6 20 0 0.780 1.000 1.000 511 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3) 11287042 74 63 72 29 15 19 19 8 13 0 0.852 1.000 1.000 512 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(5), ARFGAP3(5), ARFGEF2(14), CLTA(1), COPA(14), GBF1(17), GPLD1(10), KDELR1(1), KDELR3(3) 13048441 71 62 71 17 7 25 18 11 10 0 0.226 1.000 1.000 513 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(9), CYP11A1(5), CYP11B2(24), CYP17A1(6), HSD11B1(9), HSD3B1(6), HSD3B2(15) 5575349 74 62 73 29 13 28 16 6 10 1 0.567 1.000 1.000 514 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(3), CALM2(1), CCL2(2), CCL4(2), CCR5(4), CXCL12(3), CXCR4(6), FOS(3), GNAQ(5), JUN(3), MAPK14(4), MAPK8(2), PLCG1(7), PRKCA(10), PTK2B(14), SYT1(6) 11118315 75 61 75 23 11 30 12 6 16 0 0.437 1.000 1.000 515 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(3), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), SDS(4), SULT1B1(10), SULT1C2(3), SULT1C4(2), SULT4A1(6) 10064685 67 61 67 24 6 32 11 5 13 0 0.790 1.000 1.000 516 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(10), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP7(3), CASP8(6), CASP9(6), DFFA(3), DFFB(4), GZMB(6), PRF1(8), SCAP(6), SREBF1(3), SREBF2(2) 14452849 75 61 75 22 1 26 18 12 18 0 0.579 1.000 1.000 517 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(5), DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(11), IDI1(2), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4) 10504983 67 60 65 20 11 18 16 7 14 1 0.497 1.000 1.000 518 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), CHRNB1(5), CHRNG(7), MUSK(12), PIK3R1(4), PTK2(6), PTK2B(14), RAPSN(3), SRC(2), TERT(7), YWHAH(1) 11302945 64 59 63 23 12 21 11 7 13 0 0.506 1.000 1.000 519 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), CASP9(6), CHUK(7), GH1(7), GHR(19), NFKB1(6), NFKBIA(4), PDPK1(3), PIK3R1(4), PPP2CA(1), RELA(3), YWHAH(1) 9573891 64 59 63 26 2 28 10 6 18 0 0.905 1.000 1.000 520 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3) 5218640 69 59 68 35 20 18 15 7 9 0 0.908 1.000 1.000 521 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3) 5218640 69 59 68 35 20 18 15 7 9 0 0.908 1.000 1.000 522 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(3), AFMID(4), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2) 10822334 63 59 62 24 8 22 11 8 14 0 0.712 1.000 1.000 523 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1D(7), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(10), PER2(11), PER3(11) 13642370 71 59 69 18 8 28 17 6 11 1 0.282 1.000 1.000 524 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF2S2(3), EIF2S3(3), EIF4E(4), GSK3B(4), IGF1(4), IGF1R(8), INPPL1(11), PDK2(3), PDPK1(3), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3) 14075259 68 59 67 20 8 29 11 6 14 0 0.423 1.000 1.000 525 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(29), GNB1(2), GNGT1(6), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10) 7619071 73 58 70 21 23 28 11 5 5 1 0.455 1.000 1.000 526 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), BLVRB(2), HMOX1(3), IL10(2), IL10RA(6), IL10RB(6), IL1A(4), IL6(2), JAK1(11), STAT1(7), STAT3(11), STAT5A(3), TNF(2) 9843447 62 58 62 16 4 15 15 13 15 0 0.461 1.000 1.000 527 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(3), GH1(7), GHR(19), HRAS(2), IGF1(4), IGF1R(8), PIK3R1(4), SHC1(6), SOD1(1), SOD2(6), SOD3(1) 8940033 64 58 62 19 5 31 11 4 13 0 0.347 1.000 1.000 528 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), DIABLO(1) 10829222 65 58 65 24 2 26 17 6 14 0 0.925 1.000 1.000 529 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(8), UBE2A(7), UBE2B(1), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2E3(6), UBE2G2(1), UBE2I(2), UBE2J1(3), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(18) 8388658 62 58 61 19 4 27 12 6 13 0 0.574 1.000 1.000 530 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 CD3D(2), CD3E(2), GZMB(6), HLA-A(8), ICAM1(2), ITGAL(26), ITGB2(8), PRF1(8) 6816006 62 57 62 25 8 20 16 5 13 0 0.779 1.000 1.000 531 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PRKACA(3), PRKAR1A(2) 5210467 68 57 65 24 22 23 11 4 6 2 0.704 1.000 1.000 532 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(5), ASPH(6), COPS5(3), CREB1(2), EDN1(1), EP300(11), EPO(6), HIF1A(2), JUN(3), LDHA(10), NOS3(12), P4HB(5), VHL(1) 13589874 67 57 67 21 4 19 18 3 23 0 0.769 1.000 1.000 533 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(6) 8572537 61 57 61 31 10 22 17 5 7 0 0.945 1.000 1.000 534 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(2), ACOT11(4), ACYP2(1), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), FN3K(1), GCDH(7), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1) 20889072 71 57 69 23 9 22 18 8 14 0 0.706 1.000 1.000 535 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3), SHMT1(2) 12868967 66 57 65 28 9 28 8 8 12 1 0.858 1.000 1.000 536 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), E2F1(3), RBL1(7), TFDP1(10) 10968375 72 56 71 20 6 28 14 9 15 0 0.416 1.000 1.000 537 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(6) 8067073 60 56 60 29 7 21 18 5 9 0 0.925 1.000 1.000 538 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(30), EP300(11), ESR1(12), MAPK1(2), MAPK3(3), PELP1(10), SRC(2) 11815841 70 56 70 17 14 25 17 2 12 0 0.147 1.000 1.000 539 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(4), FOSL2(3), IFNAR1(4), IFNAR2(7), IFNB1(7), MAPK8(2), NFKB1(6), RELA(3), TNFRSF11A(9), TNFSF11(5), TRAF6(6) 8948107 59 56 59 15 4 22 14 6 13 0 0.397 1.000 1.000 540 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(9), E2F1(3), MDM2(5), MYC(4), PIK3R1(4), POLR1A(13), POLR1B(11), POLR1D(2), TBX2(8), TWIST1(2) 11959402 61 55 60 22 13 18 15 4 11 0 0.704 1.000 1.000 541 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(3), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2) 10332673 59 55 58 22 6 20 11 8 14 0 0.710 1.000 1.000 542 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(9), ANKRD1(6), CYR61(2), DUSP14(2), EIF4E(4), IFNG(7), IFRD1(4), IL1A(4), IL1R1(2), JUND(1), MYOG(1), NR4A3(7), WDR1(9) 8580866 58 55 58 17 4 19 15 8 11 1 0.607 1.000 1.000 543 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 544 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), TNFAIP3(6), TRAF3(4), TRAF6(6) 14639467 59 54 59 28 5 18 14 7 15 0 0.986 1.000 1.000 545 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 546 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 547 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(15), AGT(4), AGTR1(9), AGTR2(6), BDKRB2(3), KNG1(9), NOS3(12), REN(6) 7816341 64 53 64 32 8 31 11 6 8 0 0.896 1.000 1.000 548 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(5), CDKN1A(2), EPO(6), EPOR(2), GRIN1(9), HIF1A(2), JAK2(16), NFKB1(6), NFKBIA(4), RELA(3), SOD2(6) 10072951 61 53 60 19 3 20 18 5 15 0 0.684 1.000 1.000 549 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(5), ACOX3(8), FADS2(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3) 8123278 67 53 67 24 6 28 17 8 8 0 0.710 1.000 1.000 550 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(16), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(5) 9257582 58 53 58 21 7 15 13 12 11 0 0.789 1.000 1.000 551 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), NAT1(4), NAT2(5), XDH(18) 6470567 56 52 56 23 7 28 10 7 4 0 0.633 1.000 1.000 552 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(3), PGM3(3), TGDS(1) 9290356 61 52 61 26 17 19 11 6 8 0 0.811 1.000 1.000 553 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), SIRT1(2), SIRT2(2), SIRT5(1), SIRT7(4), VNN2(14) 9526617 56 52 54 15 8 19 13 5 11 0 0.436 1.000 1.000 554 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8) 10638297 57 52 57 19 7 19 16 5 10 0 0.686 1.000 1.000 555 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(5), ACOX3(8), ELOVL2(6), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(18), HADHA(3), HSD17B12(4), PECR(3), SCD(3) 11182281 57 51 57 14 9 23 10 8 7 0 0.171 1.000 1.000 556 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(4), CTSD(3), ESR1(12), GREB1(31), HSPB1(1), HSPB2(1), MTA1(6), MTA3(2), PDZK1(3), TUBA8(1) 8607341 64 51 63 25 13 19 15 3 14 0 0.632 1.000 1.000 557 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(2), GGT1(1), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), PAPSS1(5), PAPSS2(10), SCLY(4), SEPHS1(4) 9934310 56 51 56 27 7 23 10 5 11 0 0.943 1.000 1.000 558 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), PGM1(3), PGM3(3), TGDS(1) 8218088 59 51 59 25 17 19 11 5 7 0 0.831 1.000 1.000 559 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), CREM(3), FOS(3), JUN(3), MAPK3(3), OPRK1(12), POLR2A(11), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 10358187 61 50 61 27 11 23 14 6 6 1 0.926 1.000 1.000 560 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(6), DHFR(2), HPRT1(1), IMPDH1(7), MTHFD2(2), OAZ1(1), POLB(4), POLD1(7), POLG(12), PRPS2(4), RRM1(6), SRM(2) 9912415 56 50 56 13 8 19 11 9 9 0 0.223 1.000 1.000 561 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(4), MMP2(24), MMP9(10), RECK(9), TIMP1(1), TIMP2(2), TIMP3(4), TIMP4(4) 6044842 60 50 60 24 9 22 15 4 10 0 0.792 1.000 1.000 562 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(9), LARS(14), LARS2(2), PDHA1(5), PDHA2(29) 8106531 62 50 62 19 8 26 9 7 12 0 0.669 1.000 1.000 563 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMD14(2), RPN1(3), RPN2(4), UBE2A(7), UBE3A(18) 10426013 56 49 56 13 5 22 14 9 6 0 0.258 1.000 1.000 564 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(10), CKM(4), EIF4E(4), FBL(8), LDHA(10), LDHB(4), LDHC(6), MAPK14(4), NCL(10) 7183673 60 49 60 18 9 24 8 7 12 0 0.530 1.000 1.000 565 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(10), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), HSD3B7(7), PON1(3), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 7249371 51 48 51 18 5 24 11 3 8 0 0.583 1.000 1.000 566 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(5), ACO2(3), ACSS1(5), ACSS2(4), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SUCLA2(5) 10748299 52 48 52 19 5 16 5 10 16 0 0.710 1.000 1.000 567 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(4), IFNAR2(7), IFNB1(7), JAK1(11), STAT1(7), STAT2(6), TYK2(5) 8678322 49 47 49 12 4 19 9 9 8 0 0.319 1.000 1.000 568 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(10), BAK1(3), BAX(3), BCL10(4), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), CASP9(6), CES1(8) 8626031 48 47 48 22 5 22 11 6 4 0 0.970 1.000 1.000 569 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMC2(3), PSMD1(8), PSMD11(7), PSMD12(4), PSMD13(4), PSMD2(3), PSMD6(2) 12929204 53 45 53 10 5 27 10 5 6 0 0.117 1.000 1.000 570 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), IDI1(2), LSS(10), MVD(2), MVK(4), NQO2(3), PMVK(2), SQLE(4) 8778102 47 44 45 18 9 11 11 8 8 0 0.787 1.000 1.000 571 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(2), FH(13), IDH2(2), MDH1(3), OGDH(10), SDHA(8), SUCLA2(5) 7617727 46 44 45 16 7 14 7 6 12 0 0.607 1.000 1.000 572 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), KARS(8) 5621956 50 44 50 17 5 25 9 7 4 0 0.754 1.000 1.000 573 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), GRB2(6), HRAS(2), PTK2B(14), SHC1(6), SOS1(17), SRC(2) 7080935 49 43 47 14 9 15 13 6 6 0 0.461 1.000 1.000 574 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(12), GAD1(7), HDC(16), PNMT(1), TH(7), TPH1(8) 4758284 51 43 51 18 10 20 9 3 9 0 0.524 1.000 1.000 575 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(11), LDLR(9), MBTPS1(7), MBTPS2(7), SCAP(6), SREBF1(3), SREBF2(2) 9331112 45 43 45 14 5 14 13 4 7 2 0.572 1.000 1.000 576 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(5), GSS(4), NFKB1(6), NOX1(8), RELA(3), SOD1(1), TNF(2), XDH(18) 8029467 47 42 47 21 3 22 11 6 5 0 0.903 1.000 1.000 577 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CSK(2), GRB2(6), PRKCA(10), PTPRA(11), SRC(2) 7390964 46 42 46 18 8 17 8 5 8 0 0.752 1.000 1.000 578 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(2), CAPNS1(1), CAPNS2(2), CDK5(3), CDK5R1(3), CSNK1A1(2), CSNK1D(7), GSK3B(4), MAPT(15), PPP2CA(1) 7346627 49 41 49 19 8 22 9 4 6 0 0.785 1.000 1.000 579 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), WASF1(10), WASL(7) 6550870 45 41 45 19 4 13 13 5 10 0 0.933 1.000 1.000 580 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(4), MAPK8(2), NFKB1(6), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFSF13B(1), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6) 11647677 48 41 48 26 5 13 9 7 14 0 0.996 1.000 1.000 581 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(13), ERBB3(11), NRG1(18), UBE2D1(1) 6181944 43 39 40 15 8 13 8 2 12 0 0.826 1.000 1.000 582 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), ACO2(3), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SDHB(1), SUCLA2(5) 7200223 41 39 41 15 3 14 3 8 13 0 0.715 1.000 1.000 583 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(2), ALAS2(6), CPO(4), FECH(4), GATA1(6), HBA2(2), HBB(9), HMBS(5), UROS(2) 6361596 41 38 41 25 2 21 8 3 7 0 0.992 1.000 1.000 584 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(5), CASP7(3), DFFA(3), DFFB(4), GZMB(6), HMGB1(2), TOP2A(10), TOP2B(10) 7110700 43 38 43 10 1 10 11 5 16 0 0.625 1.000 1.000 585 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(5), EGF(13), HGS(1), RAB5A(2), TF(13), TFRC(6) 8191740 40 36 39 14 3 17 13 3 4 0 0.869 1.000 1.000 586 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(2), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(11), HMGCS2(7), OXCT1(7), OXCT2(2) 5814519 38 36 38 15 3 11 12 3 8 1 0.896 1.000 1.000 587 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4) 6322492 39 36 38 22 6 13 9 2 9 0 0.970 1.000 1.000 588 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(18), GNA12(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2) 8129650 38 34 38 11 5 15 10 4 4 0 0.637 1.000 1.000 589 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(4), FUT2(1), FUT9(15), GCNT2(5), ST8SIA1(6) 4888396 34 33 33 17 3 17 6 3 5 0 0.836 1.000 1.000 590 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHB(4), LDHC(6) 5511713 35 33 35 12 4 13 5 4 9 0 0.720 1.000 1.000 591 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(7), EIF2S2(3), EIF2S3(3), EIF5(1), GSK3B(4), PPP1CA(2) 9270131 32 32 32 11 2 14 5 3 8 0 0.825 1.000 1.000 592 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(5), CD36(4), FOS(3), FYN(8), JUN(3), MAPK14(4), THBS1(8) 5972133 35 31 35 10 5 11 6 2 11 0 0.591 1.000 1.000 593 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), CYCS(2), GPD2(9), NDUFA1(2), SDHA(8), SDHB(1), SDHD(3), UQCRC1(2) 5355877 31 30 30 17 8 11 8 0 4 0 0.982 1.000 1.000 594 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(9), NR0B2(3), NR1H3(4), NR1H4(14), RXRA(1) 4348769 34 30 34 13 7 13 9 2 3 0 0.640 1.000 1.000 595 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(1), APOBEC2(1), APOBEC3A(3), APOBEC3B(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(5), APOBEC4(7) 5940270 32 30 31 14 5 12 4 4 7 0 0.870 1.000 1.000 596 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(7), PRKCA(10), PTK2B(14) 5418338 34 30 34 12 12 11 5 2 4 0 0.550 1.000 1.000 597 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), LTB4R(5), P2RY1(4), P2RY2(3), P2RY6(2) 4799440 31 30 31 15 10 6 6 4 5 0 0.807 1.000 1.000 598 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(2), GRIA2(28), JUND(1), PPP1R1B(1) 2959877 35 29 35 14 4 13 10 0 8 0 0.776 1.000 1.000 599 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(2), ALAS2(6), CPOX(4), FECH(4), HMBS(5), PPOX(7), UROS(2) 6125365 31 29 31 20 1 10 11 3 6 0 0.997 1.000 1.000 600 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(5), B3GALT2(4), B3GALT5(3), B3GNT5(5), FUT1(4), FUT2(1), FUT3(5), ST3GAL3(4), ST3GAL4(4) 5787730 35 29 35 10 8 12 7 3 5 0 0.362 1.000 1.000 601 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4) 13355738 33 29 33 15 2 10 9 4 8 0 0.957 1.000 1.000 602 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(4), CASP8(6), FADD(2), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5) 6647115 34 29 34 10 4 10 12 4 4 0 0.525 1.000 1.000 603 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(10), EPHX2(3), HSD3B7(7), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 3845148 30 27 30 12 5 15 6 1 3 0 0.650 1.000 1.000 604 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(2), MDH1(3), ME1(3), PC(9), PDHA1(5), SLC25A11(3) 7432397 28 27 28 11 4 7 4 9 4 0 0.739 1.000 1.000 605 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(7), DNAJC3(5), EIF2S2(3), NFKB1(6), NFKBIA(4), RELA(3) 7195967 28 27 28 13 1 8 4 5 10 0 0.956 1.000 1.000 606 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 CREB1(2), FOS(3), FXYD2(1), JUN(3), MAFG(1), MAPK1(2), MAPK14(4), MAPK8(2), PRKCA(10) 5200078 28 26 28 12 4 8 8 1 7 0 0.909 1.000 1.000 607 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(11), CES1(8), ESD(2) 4884444 27 25 27 10 6 10 4 3 4 0 0.528 1.000 1.000 608 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(16), SNAP25(5) 2633838 26 25 26 11 4 8 5 3 6 0 0.845 1.000 1.000 609 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(3), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(6) 4525222 25 25 25 18 2 5 10 1 7 0 0.996 1.000 1.000 610 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(2), CSF1(1), IL6(2), LDLR(9), LPL(8) 4286004 24 23 24 11 5 7 4 5 3 0 0.872 1.000 1.000 611 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB10(1), PSMB5(1), PSMB6(1) 7053300 23 21 23 7 4 8 6 3 2 0 0.593 1.000 1.000 612 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(1), NFYB(1), NFYC(6), SP1(6), SP3(6) 3973346 20 20 20 11 0 5 7 1 7 0 0.980 1.000 1.000 613 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 4 BCKDK(2), CBS(1), CTH(2), MUT(13) 3335407 18 18 18 14 3 6 4 1 4 0 0.993 1.000 1.000 614 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 BGN(6), DCN(5), FMOD(3), KERA(7) 2376887 21 17 21 11 2 4 9 4 2 0 0.939 1.000 1.000 615 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(1), IL1B(1), MST1R(7), TNF(2) 5164336 13 13 13 9 1 7 0 3 2 0 0.931 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 412157 1 1 1 2 0 0 0 1 0 0 0.987 1.000 1.000