rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(53), ATR(26), BRCA1(22), BRCA2(31), CHEK1(7), CHEK2(10), FANCA(7), FANCC(2), FANCD2(4), FANCE(3), FANCF(4), FANCG(7), HUS1(4), MRE11A(13), RAD1(1), RAD17(6), RAD50(10), RAD51(2), RAD9A(2), TP53(309), TREX1(1) 35575939 524 354 387 37 58 144 83 68 166 5 <1.00e-15 <1.00e-15 <1.23e-13 2 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(9), ATM(53), BRCA1(22), CDKN1A(2), CHEK1(7), CHEK2(10), GADD45A(2), JUN(3), MAPK8(2), MDM2(5), MRE11A(13), NFKB1(6), NFKBIA(4), RAD50(10), RAD51(2), RBBP8(6), RELA(3), TP53(309), TP73(7) 23963460 475 347 337 35 59 126 70 56 159 5 <1.00e-15 <1.00e-15 <1.23e-13 3 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(10), ATM(53), BAX(3), BCL2(5), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDKN1A(2), E2F1(3), GADD45A(2), MDM2(5), PCNA(1), RB1(33), TIMP3(4), TP53(309) 14566640 444 342 306 24 53 111 57 50 168 5 <1.00e-15 <1.00e-15 <1.23e-13 4 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(53), ATR(26), CDC25C(8), CHEK1(7), CHEK2(10), TP53(309), YWHAH(1) 12948811 414 334 278 13 51 105 51 52 150 5 <1.00e-15 <1.00e-15 <1.23e-13 5 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), IFNG(7), IFNGR1(7), IFNGR2(4), IKBKB(9), JAK2(16), LIN7A(7), NFKB1(6), NFKBIA(4), RB1(33), RELA(3), TNF(2), TNFRSF1B(2), TP53(309), USH1C(13), WT1(16) 14547980 440 329 304 37 54 114 55 41 172 4 <1.00e-15 <1.00e-15 <1.23e-13 6 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(9), ATM(53), ATR(26), CCNA1(7), CCND1(3), CCNE1(7), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), CDKN2A(22), DHFR(2), E2F1(3), GSK3B(4), HDAC1(4), RB1(33), SKP2(3), TFDP1(10), TGFB1(3), TGFB2(10), TP53(309) 24262756 528 351 385 42 63 138 71 57 194 5 <1.00e-15 1.33e-15 1.37e-13 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(4), MAX(8), MYC(4), SP1(6), SP3(6), TP53(309), WT1(16) 5699587 353 306 218 16 48 95 38 36 133 3 <1.00e-15 1.89e-15 1.66e-13 8 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(7), DNAJC3(5), EIF2S2(3), NFKB1(6), NFKBIA(4), RELA(3), TP53(309) 7863806 337 303 203 17 43 87 37 38 129 3 <1.00e-15 2.22e-15 1.67e-13 9 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), BCL2(5), EGFR(86), IGF1R(8), MYC(4), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(33), TEP1(39), TERF1(4), TERT(7), TNKS(11), TP53(309), XRCC5(9) 22681635 540 351 356 50 62 137 64 70 204 3 <1.00e-15 2.44e-15 1.67e-13 10 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(1), CCND1(3), CDK2(1), CDK4(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), E2F1(3), E2F2(5), MDM2(5), NXT1(2), PRB1(5), TP53(309) 6739941 367 307 228 15 50 100 42 38 134 3 <1.00e-15 2.89e-15 1.77e-13 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CDK2(1), CDK4(3), CHEK1(7), MYT1(24), RB1(33), TP53(309), WEE1(4), YWHAH(1) 14151904 448 341 310 18 54 107 51 50 181 5 <1.00e-15 3.44e-15 1.77e-13 12 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(9), CDKN2A(22), E2F1(3), MDM2(5), MYC(4), PIK3CA(30), PIK3R1(4), POLR1A(13), POLR1B(11), POLR1D(2), RB1(33), TBX2(8), TP53(309), TWIST1(2) 16255854 455 322 305 32 58 122 63 43 166 3 <1.00e-15 3.44e-15 1.77e-13 13 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(45), AKT1(3), ATM(53), BAX(3), CDKN1A(2), CPB2(6), CSNK1A1(2), CSNK1D(7), FHL2(2), GADD45A(2), HIC1(1), HIF1A(2), IGFBP3(4), MAPK8(2), MDM2(5), NFKBIB(3), TP53(309) 16675533 451 346 314 27 53 131 58 51 153 5 <1.00e-15 3.89e-15 1.84e-13 14 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(30), DAXX(8), HRAS(2), PAX3(10), PML(12), RARA(7), RB1(33), SIRT1(2), SP100(18), TNF(2), TNFRSF1B(2), TP53(309) 15237396 435 318 300 22 58 112 60 42 160 3 <1.00e-15 4.88e-15 2.05e-13 15 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), CASP3(5), CASP6(3), CASP7(3), CASP9(6), CYCS(2), PRKCA(10), PTK2(6), PXN(1), STAT1(7), TLN1(15), TP53(309) 22055995 446 350 309 45 54 127 57 52 151 5 3.12e-14 5.00e-15 2.05e-13 16 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(53), ATR(26), BRCA1(22), CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CDC34(2), CDKN1A(2), CDKN2D(2), CHEK1(7), CHEK2(10), EP300(11), GADD45A(2), MDM2(5), MYT1(24), PRKDC(50), RPS6KA1(6), TP53(309), WEE1(4), YWHAH(1), YWHAQ(4) 33656030 555 364 419 43 61 154 83 69 183 5 <1.00e-15 7.66e-15 2.95e-13 17 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), FOS(3), FXYD2(1), JUN(3), KEAP1(96), MAFG(1), MAPK1(2), MAPK14(4), MAPK8(2), NFE2L2(17), PRKCA(10) 7086933 141 131 130 14 28 41 26 14 32 0 4.27e-06 2.05e-10 7.41e-09 18 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(13), EGFR(86), ERBB3(11), NRG1(18), UBE2D1(1) 8318955 129 109 78 18 11 26 16 30 46 0 0.0242 0.00546 0.187 19 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(7), CDK2(1), CDKN1B(5), CKS1B(1), CUL1(14), E2F1(3), NEDD8(3), RB1(33), SKP2(3), TFDP1(10), UBE2M(1) 6881889 81 67 80 7 5 14 15 7 40 0 0.00191 0.0706 1.000 20 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), FBXW7(15), RB1(33), TFDP1(10) 6588121 85 67 84 7 6 20 13 7 39 0 0.000710 0.0779 1.000 21 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(13), EGFR(86), HGS(1), RAB5A(2), TF(13), TFRC(6) 10328751 126 104 77 17 6 30 21 31 38 0 0.0308 0.148 1.000 22 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), RB1(33), SKP2(3), TFDP1(10) 6820981 80 65 79 7 5 20 15 7 33 0 0.00138 0.153 1.000 23 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), FADD(2), FAS(4), FASLG(10), GZMB(6), JUN(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MCL1(1), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), PARP1(4), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TNFSF10(3), TP53(309), TRADD(2), TRAF1(2), TRAF2(5) 30063453 487 333 353 68 55 154 73 52 150 3 3.32e-11 0.503 1.000 24 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(3), GOT2(6), TAT(9), TYR(29) 3808360 55 53 55 9 8 22 11 6 8 0 0.0326 0.603 1.000 25 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(6), TAT(9) 2128311 18 18 18 2 5 7 3 2 1 0 0.0759 0.623 1.000 26 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(7), IL12A(2), IL12B(3), IL2(7) 2403481 27 26 27 5 1 16 0 1 8 1 0.201 0.732 1.000 27 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(13), EGFR(86), MAP2K1(10), MAP3K1(7), MAPK14(4), NCOR2(30), RARA(7), RXRA(1), THRA(5), THRB(4) 13649211 167 133 117 28 10 40 29 37 51 0 0.0333 0.920 1.000 28 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 584333 7 7 7 3 2 1 0 2 2 0 0.742 0.926 1.000 29 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(6), SLPI(1) 1382720 7 7 6 1 1 2 1 1 2 0 0.354 0.930 1.000 30 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(9) 1324024 11 10 11 3 1 3 5 0 2 0 0.593 0.960 1.000 31 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(10), CDC42(1), DLD(9), DUSP10(11), DUSP4(2), DUSP8(2), GAB1(7), GADD45A(2), GCK(6), IL1R1(2), JUN(3), MAP2K4(8), MAP2K5(4), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK10(6), MAPK7(7), MAPK8(2), MAPK9(8), MYEF2(12), NFATC3(15), NR2C2(2), PAPPA(32), SHC1(6), TP53(309), TRAF6(6), ZAK(7) 40358111 605 356 469 78 86 195 84 60 177 3 1.23e-14 0.972 1.000 32 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(7), PAPSS1(5), PAPSS2(10), SULT1A2(5), SULT1E1(11), SULT2A1(6), SUOX(5) 4954097 49 45 49 7 3 21 9 7 9 0 0.0373 0.977 1.000 33 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(8), GLS2(6), GLUD1(4), GLUD2(15) 3672284 33 31 33 5 0 17 9 2 5 0 0.130 0.983 1.000 34 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(4), CD4(8), CD80(3), HLA-DRA(3), HLA-DRB1(5), IL10(2), IL2(7), IL4(1) 3223968 33 29 29 7 1 14 1 3 14 0 0.418 0.988 1.000 35 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 1235104 3 3 3 0 0 1 0 1 1 0 0.495 0.990 1.000 36 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2), CD3E(2) 923089 4 4 4 2 0 0 1 1 2 0 0.858 0.992 1.000 37 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(3), BFAR(5), BRAF(44), CAMP(4), CREB1(2), CREB5(18), MAPK1(2), RAF1(6), SNX13(9), SRC(2) 8973163 95 80 70 12 8 42 29 2 13 1 0.00220 0.993 1.000 38 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(5), IDI1(2), SQLE(4) 2563848 15 15 15 3 2 5 4 1 3 0 0.434 0.993 1.000 39 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(8), ALDH1A2(8), RDH5(1) 3156193 17 17 17 2 1 7 3 4 2 0 0.122 0.993 1.000 40 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(5) 1692843 8 7 8 2 0 4 0 2 2 0 0.527 0.995 1.000 41 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(4), CD4(8), HLA-DRA(3), HLA-DRB1(5) 1927106 20 20 16 6 1 9 1 2 7 0 0.708 0.996 1.000 42 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(44), CPEB1(12), EGFR(86), ERBB2(12), ERBB4(51), ETS1(8), ETS2(6), ETV6(5), ETV7(2), FMN2(65), GRB2(6), KRAS(169), MAP2K1(10), MAPK1(2), MAPK3(3), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), PIWIL1(17), PIWIL2(10), PIWIL3(9), PIWIL4(7), RAF1(6), SOS1(17), SOS2(13), SPIRE1(5), SPIRE2(5) 41513875 686 397 444 100 52 330 125 64 112 3 3.18e-13 0.996 1.000 43 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(10), ATM(53), ATR(26), BAI1(24), BAX(3), BID(2), CASP3(5), CASP8(6), CASP9(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG1(2), CCNG2(1), CD82(5), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN2A(22), CHEK1(7), CHEK2(10), CYCS(2), DDB2(2), EI24(1), FAS(4), GADD45A(2), GADD45B(1), GADD45G(1), GTSE1(6), IGF1(4), IGFBP3(4), MDM2(5), MDM4(4), PERP(1), PPM1D(8), PTEN(11), RCHY1(2), RFWD2(16), RRM2(6), RRM2B(3), SERPINB5(8), SERPINE1(14), SESN1(1), SESN2(5), SESN3(2), SFN(1), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(3), TP53(309), TP53I3(2), TP73(7), TSC2(13), ZMAT3(5) 52014903 711 379 569 91 81 220 117 80 206 7 <1.00e-15 0.997 1.000 44 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(5), GGPS1(2), IDI1(2), IDI2(1), SQLE(4) 3440819 18 18 18 3 2 7 5 1 3 0 0.308 0.997 1.000 45 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(8), HLCS(3), SPCS1(1), SPCS3(2) 2479058 14 14 14 3 1 6 5 1 1 0 0.385 0.997 1.000 46 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(6), PGLYRP2(9) 1454837 15 15 14 5 0 4 4 3 4 0 0.632 0.998 1.000 47 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1) 11082061 102 86 100 12 10 26 15 16 33 2 0.00197 0.998 1.000 48 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(8), GLUD1(4), OAT(3), PRODH(4) 4404565 27 26 27 4 3 11 6 2 5 0 0.131 0.999 1.000 49 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NFS1(5), PHPT1(1), THTPA(1), TPK1(11) 5148488 43 39 41 7 2 17 12 6 6 0 0.111 0.999 1.000 50 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(13), CYP2C9(8) 1642731 21 21 21 7 3 9 4 2 3 0 0.625 0.999 1.000 51 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(2), HGD(5) 1795382 9 8 9 4 0 2 0 2 5 0 0.846 0.999 1.000 52 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(6), CCND1(3), CCNE1(7), CCNE2(3), CDK2(1), CDK4(3), CDKN1B(5), CDKN2A(22), E2F1(3), E2F2(5), E2F4(5), PRB1(5) 7145755 75 64 70 11 10 28 14 5 18 0 0.0127 1.000 1.000 53 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(5), TGDS(1), UGDH(6), UGP2(4), UXS1(6) 3969223 22 21 22 4 2 8 4 3 5 0 0.365 1.000 1.000 54 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(4), EHHADH(13), HADHA(3), SDS(4) 3872652 25 23 24 5 4 8 5 4 4 0 0.265 1.000 1.000 55 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(4), ALDOB(8), ALDOC(2), TPI1(9) 3157676 25 21 25 5 3 9 7 0 6 0 0.285 1.000 1.000 56 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(5), TGDS(1), UGDH(6), UXS1(6) 3115757 18 17 18 4 2 8 3 2 3 0 0.432 1.000 1.000 57 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD28(4), CD3D(2), CD3E(2), CD4(8) 2606736 20 20 20 6 1 9 1 4 5 0 0.494 1.000 1.000 58 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCR3(4), HLA-DRA(3), HLA-DRB1(5), IL3(4), IL5(2) 2466150 20 20 16 6 0 5 5 4 6 0 0.842 1.000 1.000 59 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(4), CD4(8), HLA-DRA(3), HLA-DRB1(5), IL1B(1), IL4(1), IL5(2), IL5RA(9), IL6(2) 4330878 37 36 33 9 1 11 7 5 13 0 0.548 1.000 1.000 60 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), TYR(29) 7810350 94 85 93 17 10 37 19 11 17 0 0.0332 1.000 1.000 61 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(2), CHEK1(7), NEK1(11), WEE1(4) 5532285 32 30 32 5 1 11 8 5 7 0 0.214 1.000 1.000 62 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(4), GGT1(1), SHMT1(2), SHMT2(2) 3314036 9 9 8 0 2 3 2 1 1 0 0.0776 1.000 1.000 63 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(5), COQ5(3), COQ6(1), COQ7(5), NDUFA12(5), NDUFA13(1), NDUFB11(6) 3215199 27 24 27 8 7 6 3 3 8 0 0.553 1.000 1.000 64 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAK1(3), BAX(3), BFAR(5), BTK(25), CAD(25), CASP10(7), CASP3(5), CASP8(6), CSNK1A1(2), DAXX(8), DEDD(2), DEDD2(3), DFFA(3), DIABLO(1), EGFR(86), EPHB2(10), FADD(2), FAF1(10), FAIM2(6), HSPB1(1), IL1A(4), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MET(22), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR0B2(3), PFN1(1), PFN2(1), PTPN13(21), RALBP1(3), RIPK1(11), ROCK1(19), SMPD1(3), TNFRSF6B(1), TP53(309), TPX2(12), TRAF2(5) 58000166 732 390 547 101 77 217 113 98 223 4 6.77e-15 1.000 1.000 65 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(2), HMGCL(1), OXCT1(7) 2736802 12 12 12 9 1 2 3 2 4 0 0.994 1.000 1.000 66 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(17), PARK2(15), SNCA(5), SNCAIP(12), UBE2E2(4), UBE2G2(1), UBE2L3(1), UBE2L6(1) 5191088 56 53 56 13 7 26 12 2 9 0 0.175 1.000 1.000 67 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), NFYC(6), RB1(33), SP1(6), SP3(6) 5366971 53 50 52 12 0 6 10 2 35 0 0.669 1.000 1.000 68 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(8), ACADS(1), ACAT1(2), ECHS1(4), HADHA(3) 4325350 22 21 22 7 0 4 5 4 9 0 0.808 1.000 1.000 69 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(8), PLCD1(4), PRKCA(10), TGM2(6) 3986370 28 25 28 8 5 12 3 5 3 0 0.341 1.000 1.000 70 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), BIRC2(2), BIRC3(4), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), GZMB(6), HELLS(4), IKBKB(9), IRF1(1), IRF2(3), IRF4(12), IRF5(1), IRF6(12), IRF7(3), JUN(3), LTA(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), NFKBIB(3), NFKBIE(2), PLEKHG5(10), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFSF10(3), TP53(309), TP73(7), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4) 45868695 607 350 474 90 69 195 94 64 182 3 3.27e-12 1.000 1.000 71 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(3), EGR1(6), HRAS(2), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(5), RAF1(6) 6499475 51 47 47 10 6 22 14 4 5 0 0.0444 1.000 1.000 72 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL16(28), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL9(1), LTA(3), TNF(2) 8021597 85 70 85 19 5 47 10 10 12 1 0.0488 1.000 1.000 73 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT1(2), ACAT2(2), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), SDS(4) 6711531 40 37 39 9 4 11 13 6 6 0 0.325 1.000 1.000 74 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3) 6404267 49 44 49 11 5 19 11 7 7 0 0.165 1.000 1.000 75 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3) 6404267 49 44 49 11 5 19 11 7 7 0 0.165 1.000 1.000 76 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(12), ESR2(6), ITPKA(2), PDE1A(17), PDE1B(13), PLCB1(52), PLCB2(12), PRL(3), TRH(4), VIP(6) 8866426 127 99 125 28 19 53 24 10 21 0 0.0217 1.000 1.000 77 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), E2F1(3), RB1(33), RBL1(7), TFDP1(10) 12813726 127 103 121 24 9 35 21 12 50 0 0.0758 1.000 1.000 78 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(7), ENO2(2), ENO3(3), FARS2(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3) 6722782 49 46 49 10 7 19 11 4 8 0 0.113 1.000 1.000 79 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(5), CASP3(5), CASP8(6), CFLAR(2) 3134220 18 17 18 8 1 6 7 1 3 0 0.873 1.000 1.000 80 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(8), ERBB4(51), NRG2(3), NRG3(31), PRKCA(10), PSEN1(6) 7252332 109 91 108 28 13 47 22 12 15 0 0.190 1.000 1.000 81 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SEC61A2(6), SRP54(5), SRP68(4), SRP72(9), SRPR(5) 6095457 33 29 32 7 2 8 12 2 9 0 0.557 1.000 1.000 82 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(34), RANGAP1(4) 6781581 39 36 39 8 6 16 9 4 4 0 0.268 1.000 1.000 83 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 EPO(6), FLT3(24), IGF1(4), IL1A(4), IL3(4), IL6(2), IL9(1), KITLG(6), TGFB1(3), TGFB2(10) 6569556 64 57 64 15 6 25 13 6 14 0 0.144 1.000 1.000 84 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5) 4573767 48 43 45 14 3 25 7 2 11 0 0.465 1.000 1.000 85 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), PHPT1(1), TYR(29) 12088037 123 101 121 22 12 52 24 15 20 0 0.0154 1.000 1.000 86 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(4), CD3D(2), CD3E(2), CD80(3), CD86(11), CTLA4(3), GRB2(6), HLA-DRA(3), HLA-DRB1(5), ICOS(5), IL2(7), ITK(16), LCK(9), PIK3CA(30), PIK3R1(4), PTPN11(9) 10376357 119 98 104 26 6 51 21 13 28 0 0.179 1.000 1.000 87 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), SDS(4) 9729696 73 64 72 15 8 27 16 11 11 0 0.0769 1.000 1.000 88 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(10), BMPR1A(4), BMPR1B(7), BMPR2(10) 5050548 31 28 30 7 5 8 10 4 4 0 0.329 1.000 1.000 89 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(7), IFNGR1(7), JAK1(11), JAK2(16), PLA2G2A(5), PTPRU(19), REG1A(20), STAT1(7) 9229358 93 77 91 19 11 37 15 9 20 1 0.0404 1.000 1.000 90 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(7), IFNGR1(7), IFNGR2(4), JAK1(11), JAK2(16), STAT1(7) 6617914 52 50 52 12 6 15 12 7 11 1 0.404 1.000 1.000 91 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(7), NR1I3(9), PTGS1(18), PTGS2(12) 4326176 49 43 48 13 3 24 10 3 9 0 0.170 1.000 1.000 92 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(5), FARSB(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3), YARS2(10) 7030650 57 53 57 12 12 19 12 3 11 0 0.0918 1.000 1.000 93 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1E(6), PER1(10) 6788509 35 31 33 7 5 12 8 2 8 0 0.247 1.000 1.000 94 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), ST3GAL3(4) 3992736 21 19 21 6 5 6 5 2 3 0 0.439 1.000 1.000 95 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(9), CSAD(6), GAD1(7), GAD2(27), GGT1(1) 4611376 50 45 50 14 4 22 10 4 10 0 0.387 1.000 1.000 96 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(3), CDC25A(4), CDC25B(1), CDC25C(8), CDK7(3), MNAT1(2), SHH(2), XPO1(12) 6942669 37 32 37 8 3 14 8 6 6 0 0.313 1.000 1.000 97 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(53), CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), CREB3L1(4), CREB3L3(3), CREB3L4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), GADD45A(2), GBA2(5), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MNAT1(2), MYC(4), MYT1(24), NACA(15), PCNA(1), POLA2(7), POLE(31), POLE2(1), PRIM1(3), RB1(33), RBL1(7), RPA1(2), RPA2(2), RPA3(1), TFDP1(10), TFDP2(7), TNXB(32), TP53(309), WEE1(4) 61819242 718 384 575 100 94 210 103 74 231 6 3.44e-15 1.000 1.000 98 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(9), LPL(8), NR3C1(8), PPARG(8), RXRA(1), TNF(2) 4649244 36 35 36 10 3 14 8 3 7 1 0.359 1.000 1.000 99 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), APEX1(3), CREBBP(30), DFFA(3), DFFB(4), GZMA(8), GZMB(6), PRF1(8), SET(1) 8510668 66 56 66 11 9 26 14 5 12 0 0.0283 1.000 1.000 100 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5) 8379151 60 54 60 13 8 20 15 8 9 0 0.166 1.000 1.000 101 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5) 8379151 60 54 60 13 8 20 15 8 9 0 0.166 1.000 1.000 102 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(6), F13B(28), HSD17B1(2), HSD17B2(6), HSD17B3(3), HSD17B4(8), HSD17B7(3), HSD3B1(6), HSD3B2(15) 6540842 77 66 76 20 7 33 16 8 12 1 0.214 1.000 1.000 103 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(30), PIK3R1(4), PLCB1(52), PLCG1(7), PRKCA(10), VAV1(8) 10362726 114 90 102 24 10 57 21 9 17 0 0.0444 1.000 1.000 104 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1) 5579121 45 38 45 10 5 19 7 3 10 1 0.233 1.000 1.000 105 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), MIOX(2), UGDH(6) 6783953 44 39 44 11 4 18 12 4 6 0 0.283 1.000 1.000 106 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(6), CD34(13), CD3D(2), CD3E(2), CD4(8), CD58(1), CD8A(4), IL3(4), IL6(2), KITLG(6) 4993395 48 39 47 15 4 21 6 4 13 0 0.469 1.000 1.000 107 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(8), CSF1(1), HLA-DRA(3), HLA-DRB1(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), LTA(3), PDGFA(5), TGFB1(3), TGFB2(10), TNF(2) 10608184 93 81 89 22 4 41 12 13 22 1 0.144 1.000 1.000 108 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(22), PDXK(2), PDXP(1), PNPO(2), PSAT1(5) 3885247 32 28 32 10 2 13 9 5 3 0 0.594 1.000 1.000 109 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(7), CHST11(2), CHST12(6), CHST13(3), PAPSS1(5), PAPSS2(10), SULT1A1(5), SULT1A2(5), SULT1E1(11), SULT2A1(6), SULT2B1(2), SUOX(5) 7381636 67 55 66 16 8 24 13 9 13 0 0.133 1.000 1.000 110 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(9), RAB27A(1), RAB4A(2), RAB5A(2), RAB6A(1) 3425847 15 14 15 9 1 5 5 3 1 0 0.974 1.000 1.000 111 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(4), AASS(20), KARS(8) 3810563 35 30 35 10 4 18 5 5 3 0 0.530 1.000 1.000 112 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(3), GH1(7), GHR(19), HRAS(2), IGF1(4), IGF1R(8), PIK3CA(30), PIK3R1(4), SHC1(6), SOD1(1), SOD2(6), SOD3(1) 10723295 94 84 82 21 5 49 19 7 14 0 0.0905 1.000 1.000 113 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(10), CSF1R(18), EGF(13), EGFR(86), GRB2(6), MET(22), PDGFRA(41), PRKCA(10), SH3GLB2(1), SH3KBP1(7), SRC(2) 15682674 216 167 164 45 18 57 34 42 64 1 0.0879 1.000 1.000 114 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(8), DLL1(5), FURIN(7), NOTCH1(26), PSEN1(6) 6936866 52 47 52 13 13 14 7 7 11 0 0.156 1.000 1.000 115 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), E2F1(3), HRAS(2), MAPK1(2), MAPK3(3), NFKB1(6), NFKBIA(4), PAK1(9), PIK3CA(30), PIK3R1(4), RAF1(6), RB1(33), RELA(3), TFDP1(10) 16217036 144 118 127 29 10 47 26 9 52 0 0.0664 1.000 1.000 116 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(4), CD3D(2), CD3E(2), IFNG(7), IL2(7), IL2RA(6), IL4(1), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), TOB1(4), TOB2(4) 8525310 83 75 83 21 5 36 14 5 22 1 0.238 1.000 1.000 117 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(3), CAMP(4), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7) 4773910 24 23 24 8 3 8 7 3 3 0 0.607 1.000 1.000 118 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), DHFR(2), FPGS(3), GCH1(3), GGH(9), SPR(3) 5125898 49 42 49 15 2 16 14 5 12 0 0.462 1.000 1.000 119 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(2), ACYP2(1), ECHS1(4), EHHADH(13), GCDH(7), HADHA(3), SDHB(1), SDS(4) 6259671 37 33 35 10 6 10 9 5 7 0 0.448 1.000 1.000 120 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(7), GGT1(1), SHMT1(2), SHMT2(2) 4406742 15 15 15 6 2 5 4 1 3 0 0.822 1.000 1.000 121 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(3), CSNK1D(7), DRD1(13), DRD2(26), GRM1(48), PLCB1(52), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 12833490 194 139 190 39 26 84 36 16 30 2 0.00175 1.000 1.000 122 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(6), CD3D(2), CD3E(2), CD4(8), CXCR3(3), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), JAK2(16), STAT4(11), TYK2(5) 11741422 89 72 89 19 7 36 15 10 20 1 0.0702 1.000 1.000 123 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(4), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8), MECR(2), PPT1(2), PPT2(6) 6827328 41 40 40 11 3 11 14 5 8 0 0.517 1.000 1.000 124 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(71), GLS(8), GLUD1(4), GOT1(3) 6263846 92 82 91 25 5 40 17 13 17 0 0.451 1.000 1.000 125 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(18), AGT(4), AGTR2(6), EDN1(1), EDNRA(3), EDNRB(16), EGF(13), EGFR(86), FOS(3), HRAS(2), JUN(3), MYC(4), NFKB1(6), PLCG1(7), PRKCA(10), RELA(3) 16592775 185 143 136 36 17 47 30 40 51 0 0.0584 1.000 1.000 126 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(8), CD8A(4), CSF1(1), EPO(6), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), IL9(1) 4807995 38 33 38 13 1 18 7 4 8 0 0.623 1.000 1.000 127 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(5), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RELA(3) 6638404 80 70 79 22 7 38 12 8 15 0 0.334 1.000 1.000 128 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(8), ALOX15(5), ALOX15B(6), ALOX5(10), ALOX5AP(2), DPEP1(5), GGT1(1), LTA4H(3), PLA2G2A(5), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11) 11922131 105 86 102 23 18 37 22 13 15 0 0.0217 1.000 1.000 129 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RB1(33), RELA(3), SP1(6) 15605414 132 111 119 27 3 44 26 10 49 0 0.155 1.000 1.000 130 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(7), FOS(3), HRAS(2), JUN(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYC(4), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RAF1(6), RELA(3), TNF(2) 12532437 117 99 112 28 14 49 20 13 21 0 0.0664 1.000 1.000 131 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PGK1(4), PKLR(16), RPE(3), RPIA(8), TKT(3), TPI1(9) 14454299 101 84 100 20 14 32 21 14 20 0 0.0258 1.000 1.000 132 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CAMKK1(4), CAMKK2(3), CREB1(2), SYT1(6) 9210287 64 59 64 16 5 26 11 7 15 0 0.227 1.000 1.000 133 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(11), ACVR1C(11), AKT1(3), AKT2(7), AKT3(7), ARRB1(2), ARRB2(4), ATF2(10), ATF4(2), BDNF(1), BRAF(44), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CACNA2D1(46), CACNA2D3(24), CACNA2D4(25), CACNB1(5), CACNB2(23), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(6), CACNG3(18), CACNG4(5), CACNG5(8), CACNG6(11), CACNG7(9), CACNG8(5), CASP3(5), CD14(1), CDC25B(1), CDC42(1), CHUK(7), CRK(1), CRKL(4), DAXX(8), DDIT3(2), DUSP1(1), DUSP10(11), DUSP14(2), DUSP16(3), DUSP2(2), DUSP3(4), DUSP4(2), DUSP5(3), DUSP6(4), DUSP7(3), DUSP8(2), DUSP9(6), EGF(13), EGFR(86), ELK1(3), ELK4(6), FAS(4), FASLG(10), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FLNA(31), FLNB(16), FLNC(55), FOS(3), GADD45A(2), GADD45B(1), GADD45G(1), GNA12(1), GNG12(3), GRB2(6), HRAS(2), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), JUN(3), JUND(1), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAPT(15), MAX(8), MEF2C(6), MKNK1(4), MKNK2(2), MOS(9), MRAS(1), MYC(4), NF1(65), NFATC2(15), NFATC4(11), NFKB1(6), NFKB2(5), NLK(3), NR4A1(5), NRAS(4), NTF3(11), NTRK1(14), NTRK2(21), PAK1(9), PAK2(3), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PPM1A(6), PPM1B(9), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PPP5C(2), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTPN5(12), PTPN7(1), PTPRR(16), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(24), RASA1(11), RASA2(8), RASGRF1(11), RASGRF2(22), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KA6(18), RRAS(1), RRAS2(3), SOS1(17), SOS2(13), SRF(1), STK3(4), STK4(6), STMN1(2), TAOK1(8), TAOK2(11), TAOK3(9), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TP53(309), TRAF2(5), TRAF6(6), ZAK(7) 227344397 2622 515 2235 655 330 1010 488 262 519 13 1.19e-10 1.000 1.000 134 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), ARHGAP5(17), BCAR1(3), BCL2(5), BIRC2(2), BIRC3(4), BRAF(44), CAPN2(5), CAV1(1), CAV2(1), CAV3(3), CCND1(3), CCND2(4), CCND3(1), CDC42(1), CHAD(1), COL11A1(138), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), CRK(1), CRKL(4), CTNNB1(20), DIAPH1(3), DOCK1(15), EGF(13), EGFR(86), ELK1(3), ERBB2(12), FARP2(7), FIGF(4), FLNA(31), FLNB(16), FLNC(55), FLT1(31), FN1(25), FYN(8), GRB2(6), GSK3B(4), HGF(54), HRAS(2), IBSP(9), IGF1(4), IGF1R(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), JUN(3), KDR(56), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), MAP2K1(10), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MET(22), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARVA(3), PARVB(3), PARVG(8), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PRKCA(10), PRKCG(20), PTEN(11), PTK2(6), PXN(1), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(7), RELN(104), RHOA(4), ROCK1(19), ROCK2(9), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SPP1(5), SRC(2), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TLN1(15), TLN2(30), TNC(26), TNN(87), TNR(112), TNXB(32), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCL(8), VEGFA(1), VEGFB(2), VEGFC(21), VTN(4), VWF(32), ZYX(6) 296509541 3289 504 3158 924 378 1412 606 274 602 17 0.000397 1.000 1.000 135 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(4), ACTN1(7), ACTN2(43), ACTN4(6), APC(33), APC2(8), ARAF(5), ARHGEF1(5), ARHGEF12(24), ARHGEF4(11), ARHGEF6(21), ARHGEF7(6), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), ARPC5(1), BAIAP2(3), BCAR1(3), BDKRB1(1), BDKRB2(3), BRAF(44), CD14(1), CDC42(1), CFL2(3), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CRK(1), CRKL(4), CSK(2), CYFIP1(12), CYFIP2(11), DIAPH1(3), DIAPH2(18), DIAPH3(16), DOCK1(15), EGF(13), EGFR(86), EZR(3), F2(9), F2R(10), FGD1(13), FGD3(8), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FN1(25), GIT1(3), GNA12(1), GNA13(6), GNG12(3), GSN(4), HRAS(2), IQGAP1(8), IQGAP2(31), IQGAP3(16), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), KRAS(169), LIMK1(3), LIMK2(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(9), MRAS(1), MSN(8), MYH10(14), MYH14(9), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), NCKAP1(11), NCKAP1L(24), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PFN1(1), PFN2(1), PFN4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R12B(15), PTK2(6), PXN(1), RAC2(2), RAF1(6), RDX(2), RHOA(4), ROCK1(19), ROCK2(9), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(6), SOS1(17), SOS2(13), SSH1(9), SSH2(9), SSH3(9), TIAM1(59), TIAM2(22), VAV1(8), VAV2(8), VAV3(32), VCL(8), WAS(8), WASF1(10), WASF2(3), WASL(7) 220926006 2186 497 1918 586 242 912 453 197 375 7 3.79e-05 1.000 1.000 136 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY7(13), ADCY8(48), ADCY9(12), ADORA2A(3), ADORA2B(1), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), ATP2B4(13), AVPR1A(14), AVPR1B(7), BDKRB1(1), BDKRB2(3), BST1(3), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CCKAR(14), CCKBR(24), CD38(4), CHRM1(5), CHRM2(39), CHRM3(27), CHRM5(6), CHRNA7(3), CYSLTR1(5), CYSLTR2(12), DRD1(13), EDNRA(3), EDNRB(16), EGFR(86), ERBB2(12), ERBB3(11), ERBB4(51), F2R(10), GNA11(4), GNA14(2), GNA15(1), GNAL(5), GNAQ(5), GNAS(29), GRIN1(9), GRIN2A(61), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), GRPR(7), HRH1(5), HRH2(17), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), LHCGR(14), MYLK(26), MYLK2(9), NOS1(29), NOS3(12), NTSR1(10), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), PDE1A(17), PDE1B(13), PDE1C(28), PDGFRA(41), PDGFRB(18), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PLN(1), PPID(2), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTAFR(5), PTGER3(9), PTGFR(12), PTK2B(14), RYR1(111), RYR2(359), RYR3(124), SLC25A5(3), SLC25A6(5), SLC8A1(55), SLC8A2(10), SLC8A3(28), SPHK2(4), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), TNNC1(1), TNNC2(2), TRHR(14), TRPC1(10), VDAC1(2), VDAC2(2), VDAC3(1) 215110975 2901 486 2806 934 437 1165 582 265 434 18 0.00591 1.000 1.000 137 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(9), ABLIM1(4), ABLIM2(4), ABLIM3(18), ARHGEF12(24), CDC42(1), CDK5(3), CFL2(3), CXCL12(3), CXCR4(6), DCC(41), DPYSL2(3), DPYSL5(10), EFNA2(1), EFNA3(2), EFNB1(2), EFNB2(4), EFNB3(1), EPHA1(9), EPHA2(10), EPHA3(56), EPHA4(18), EPHA5(78), EPHA6(59), EPHA7(40), EPHA8(21), EPHB1(44), EPHB2(10), EPHB3(14), EPHB4(10), EPHB6(53), FES(1), FYN(8), GNAI1(10), GNAI3(2), GSK3B(4), HRAS(2), ITGB1(6), KRAS(169), L1CAM(42), LIMK1(3), LIMK2(3), LRRC4C(53), MAPK1(2), MAPK3(3), MET(22), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NGEF(12), NRAS(4), NRP1(9), NTN1(1), NTN4(6), NTNG1(33), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLXNA1(16), PLXNA2(30), PLXNA3(20), PLXNB1(12), PLXNB2(21), PLXNB3(15), PLXNC1(11), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTK2(6), RAC2(2), RASA1(11), RGS3(11), RHOA(4), RHOD(2), ROBO1(31), ROBO2(54), ROBO3(19), ROCK1(19), ROCK2(9), SEMA3A(26), SEMA3C(15), SEMA3D(33), SEMA3E(15), SEMA3F(7), SEMA3G(6), SEMA4A(5), SEMA4C(7), SEMA4D(8), SEMA4F(12), SEMA4G(3), SEMA5A(59), SEMA5B(30), SEMA6A(20), SEMA6B(12), SEMA6C(10), SEMA6D(40), SEMA7A(9), SLIT1(21), SLIT2(61), SLIT3(41), SRGAP1(20), SRGAP2(7), SRGAP3(24), UNC5A(18), UNC5B(19), UNC5C(22), UNC5D(45) 156945236 2016 463 1818 549 260 907 355 160 327 7 5.97e-07 1.000 1.000 138 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(17), ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA2A(3), ADRA2B(4), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), C5AR1(7), CALCR(27), CALCRL(18), CCKAR(14), CCKBR(24), CGA(2), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CRHR1(7), CTSG(12), CYSLTR1(5), CYSLTR2(12), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2(9), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHB(4), FSHR(37), GABBR1(8), GABBR2(13), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GABRB1(21), GABRB2(10), GABRB3(37), GABRD(8), GABRE(6), GABRG1(34), GABRG2(36), GABRG3(28), GABRP(6), GABRQ(23), GABRR1(11), GABRR2(10), GALR1(8), GALR2(3), GALR3(1), GH1(7), GH2(7), GHR(19), GHRHR(5), GHSR(5), GIPR(3), GLP1R(11), GLP2R(17), GLRA1(10), GLRA2(22), GLRA3(9), GLRB(9), GNRHR(5), GPR156(16), GPR35(8), GPR50(21), GPR63(10), GPR83(12), GRIA1(18), GRIA2(28), GRIA3(24), GRIA4(25), GRID1(30), GRID2(54), GRIK1(31), GRIK2(41), GRIK3(22), GRIK4(25), GRIK5(15), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRIN3A(38), GRIN3B(6), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM6(17), GRM7(43), GRM8(52), GRPR(7), GZMA(8), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HRH4(5), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LEP(4), LEPR(26), LHB(3), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), MCHR1(4), MCHR2(16), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPBWR1(5), NPBWR2(8), NPFFR1(2), NPFFR2(22), NPY1R(17), NPY2R(20), NPY5R(22), NR3C1(8), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), P2RY1(4), P2RY10(23), P2RY11(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY4(4), P2RY6(2), P2RY8(9), PARD3(15), PRL(3), PRLHR(9), PRLR(18), PRSS1(25), PRSS3(1), PTAFR(5), PTGDR(8), PTGER2(4), PTGER3(9), PTGER4(7), PTGFR(12), PTGIR(6), PTH2R(15), RXFP1(20), RXFP2(8), SCTR(5), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SSTR5(6), TAAR1(5), TAAR2(9), TAAR5(11), TAAR6(15), TAAR8(9), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), THRA(5), THRB(4), TRHR(14), TRPV1(5), TSHB(5), TSHR(22), UTS2R(4), VIPR1(2), VIPR2(3) 177489602 2931 458 2896 1017 395 1280 597 258 392 9 0.0324 1.000 1.000 139 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRB1(1), CSNK1D(7), DRD1(13), DRD2(26), EGF(13), EGFR(86), GJA1(11), GJD2(6), GNA11(4), GNAI1(10), GNAI3(2), GNAQ(5), GNAS(29), GRB2(6), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), HTR2A(6), HTR2B(5), HTR2C(8), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K5(4), MAP3K2(6), MAPK1(2), MAPK3(3), MAPK7(7), NPR1(16), NPR2(6), NRAS(4), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), PRKX(3), RAF1(6), SOS1(17), SOS2(13), SRC(2), TJP1(15), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17) 105965928 1370 454 1149 359 156 588 274 136 212 4 2.22e-05 1.000 1.000 140 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(33), APC2(8), AXIN1(7), AXIN2(5), BTRC(12), CACYBP(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CCND1(3), CCND2(4), CCND3(1), CER1(7), CHD8(29), CREBBP(30), CSNK1A1(2), CSNK1A1L(14), CSNK1E(6), CSNK2A1(5), CSNK2A2(2), CTBP1(2), CTNNB1(20), CUL1(14), CXXC4(2), DAAM1(8), DAAM2(4), DKK1(3), DKK2(14), DKK4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), FBXW11(2), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LEF1(12), LRP5(17), LRP6(16), MAP3K7(10), MAPK10(6), MAPK8(2), MAPK9(8), MMP7(7), MYC(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKD1(6), NKD2(8), NLK(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PORCN(7), PPARD(6), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRICKLE1(11), PRICKLE2(9), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PSEN1(6), RAC2(2), RHOA(4), ROCK1(19), ROCK2(9), RUVBL1(4), SENP2(6), SFRP1(2), SFRP2(6), SFRP4(7), SFRP5(1), SIAH1(1), SKP1(4), SMAD2(7), SMAD3(6), SMAD4(21), SOX17(1), TBL1X(5), TBL1XR1(6), TBL1Y(1), TCF7(3), TCF7L1(6), TCF7L2(7), TP53(309), VANGL1(9), VANGL2(15), WIF1(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6) 128954943 1394 447 1240 317 222 484 241 134 308 5 6.28e-09 1.000 1.000 141 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), AMOTL1(11), ASH1L(33), CASK(8), CDC42(1), CDK4(3), CGN(12), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTTN(6), EPB41(2), EPB41L1(10), EPB41L2(16), EPB41L3(31), EXOC3(3), EXOC4(16), F11R(3), GNAI1(10), GNAI3(2), HCLS1(17), HRAS(2), IGSF5(6), INADL(20), JAM2(9), JAM3(4), KRAS(169), LLGL1(6), LLGL2(9), MAGI1(21), MAGI2(33), MAGI3(10), MLLT4(12), MPDZ(20), MPP5(2), MRAS(1), MYH1(70), MYH10(14), MYH11(29), MYH13(47), MYH14(9), MYH15(31), MYH2(77), MYH3(37), MYH4(53), MYH6(42), MYH7(59), MYH7B(10), MYH8(73), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NRAS(4), OCLN(1), PARD3(15), PARD6A(1), PARD6B(4), PARD6G(2), PPM1J(2), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP2R3A(2), PPP2R3B(6), PPP2R4(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PTEN(11), RAB13(1), RAB3B(1), RHOA(4), RRAS(1), RRAS2(3), SPTAN1(21), SRC(2), SYMPK(16), TJAP1(4), TJP1(15), TJP2(6), TJP3(6), VAPA(2), YES1(3), ZAK(7) 155527927 1630 447 1450 431 194 721 339 127 245 4 4.09e-05 1.000 1.000 142 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(10), ACTG1(6), CHAD(1), COL11A1(138), COL11A2(21), COL17A1(16), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), DES(4), DSC1(16), DSC2(24), DSC3(21), DSG1(29), DSG2(12), DSG3(37), DSG4(28), FN1(25), GJA1(11), GJA10(15), GJA3(3), GJA4(6), GJA5(7), GJA8(18), GJA9(12), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GJB7(6), GJC1(8), GJC2(5), GJC3(4), GJD2(6), GJD4(3), IBSP(9), INA(4), ITGA6(12), ITGB4(10), KRT1(11), KRT10(6), KRT12(8), KRT13(5), KRT14(11), KRT15(4), KRT16(8), KRT17(9), KRT19(6), KRT2(11), KRT20(5), KRT23(7), KRT24(9), KRT25(11), KRT27(3), KRT28(11), KRT3(9), KRT31(14), KRT32(3), KRT33A(7), KRT33B(7), KRT34(15), KRT35(11), KRT36(9), KRT37(14), KRT38(15), KRT39(5), KRT4(9), KRT40(7), KRT5(14), KRT6A(14), KRT6B(19), KRT6C(5), KRT7(9), KRT71(12), KRT72(14), KRT73(10), KRT74(11), KRT75(11), KRT76(4), KRT77(6), KRT78(6), KRT79(12), KRT8(3), KRT81(2), KRT82(12), KRT83(9), KRT84(5), KRT85(5), KRT86(1), KRT9(5), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), LMNA(2), LMNB1(5), LMNB2(5), NES(33), PRPH(1), RELN(104), SPP1(5), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VIM(5), VTN(4), VWF(32) 199332373 2515 443 2489 781 316 1113 472 163 438 13 0.0867 1.000 1.000 143 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ATF4(2), CACNA1C(61), CACNA1D(21), CACNA1F(30), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDC42(1), CGA(2), EGFR(86), ELK1(3), FSHB(4), GNA11(4), GNAQ(5), GNAS(29), GNRH1(1), GNRHR(5), GRB2(6), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), KRAS(169), LHB(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK9(8), MMP14(4), MMP2(24), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLD1(19), PLD2(7), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCD(7), PRKX(3), PTK2B(14), RAF1(6), SOS1(17), SOS2(13), SRC(2) 101702499 1208 441 987 321 156 516 230 109 196 1 0.000146 1.000 1.000 144 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(7), ACVR1B(11), ACVR2A(5), ACVR2B(4), AMHR2(6), BMP2(1), BMP7(12), BMPR1A(4), BMPR1B(7), BMPR2(10), CCL1(4), CCL11(2), CCL13(3), CCL14(3), CCL15(5), CCL16(4), CCL17(3), CCL18(2), CCL19(1), CCL2(2), CCL20(3), CCL21(2), CCL22(1), CCL23(3), CCL24(1), CCL25(2), CCL28(6), CCL4(2), CCL7(5), CCL8(1), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CD27(1), CD40(3), CD40LG(9), CD70(1), CNTF(6), CNTFR(5), CRLF2(9), CSF1(1), CSF1R(18), CSF2RA(8), CSF2RB(14), CSF3R(6), CX3CL1(5), CX3CR1(11), CXCL1(1), CXCL10(1), CXCL11(1), CXCL12(3), CXCL14(1), CXCL2(1), CXCL6(3), CXCL9(4), CXCR3(3), CXCR4(6), CXCR6(2), EDA(4), EDA2R(9), EDAR(8), EGF(13), EGFR(86), EPO(6), EPOR(2), FAS(4), FASLG(10), FLT1(31), FLT3(24), FLT3LG(2), FLT4(20), GDF5(12), GH1(7), GH2(7), GHR(19), HGF(54), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL15(6), IL15RA(2), IL17A(12), IL17B(2), IL17RA(4), IL18R1(12), IL18RAP(22), IL19(2), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL1RAP(4), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL25(2), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), INHBA(31), INHBB(4), INHBC(4), INHBE(5), KDR(56), KIT(12), KITLG(6), LEP(4), LEPR(26), LIF(3), LIFR(14), LTA(3), LTB(4), LTBR(1), MET(22), MPL(5), NGFR(5), OSM(5), OSMR(7), PDGFB(2), PDGFC(3), PDGFRA(41), PDGFRB(18), PF4(1), PF4V1(2), PLEKHO2(3), PPBP(2), PRL(3), PRLR(18), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(9), TNFRSF11B(3), TNFRSF12A(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF14(1), TNFRSF18(2), TNFRSF19(5), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(11), TNFRSF9(7), TNFSF10(3), TNFSF11(5), TNFSF12(1), TNFSF13B(1), TNFSF14(2), TNFSF15(3), TNFSF18(5), TNFSF4(2), TNFSF8(1), TNFSF9(3), TPO(33), TSLP(8), VEGFA(1), VEGFB(2), VEGFC(21), XCL1(7), XCL2(5), XCR1(6) 142290090 1500 434 1433 426 148 606 292 180 272 2 0.0213 1.000 1.000 145 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), ANXA6(8), ARRB1(2), ARRB2(4), ATP1A4(19), ATP1B1(6), ATP1B2(1), ATP1B3(2), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1S(23), CACNB1(5), CACNB3(1), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CASQ1(6), CASQ2(5), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), FXYD2(1), GJA1(11), GJA4(6), GJA5(7), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GNA11(4), GNAI3(2), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), ITPR1(20), ITPR2(40), ITPR3(21), KCNB1(28), KCNJ3(36), KCNJ5(10), MIB1(12), NME7(4), PEA15(1), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLN(1), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SLC8A3(28), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4) 150352635 2071 430 2040 679 301 868 426 177 282 17 0.0447 1.000 1.000 146 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(16), CD36(4), CD44(7), CD47(6), CHAD(1), COL11A1(138), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), DAG1(3), FN1(25), FNDC1(33), FNDC3A(9), FNDC4(1), FNDC5(1), GP5(8), GP6(6), HMMR(6), HSPG2(33), IBSP(9), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), RELN(104), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SPP1(5), SV2A(17), SV2B(14), SV2C(20), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VTN(4), VWF(32) 178940152 2159 430 2140 622 247 976 413 124 385 14 0.0111 1.000 1.000 147 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(9), ABL2(18), AKT1(3), AKT2(7), AKT3(7), ARAF(5), AREG(1), BRAF(44), BTC(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CBL(10), CBLB(10), CBLC(1), CDKN1A(2), CDKN1B(5), CRK(1), CRKL(4), EGF(13), EGFR(86), ELK1(3), ERBB2(12), ERBB3(11), ERBB4(51), EREG(4), GAB1(7), GRB2(6), GSK3B(4), HRAS(2), JUN(3), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MYC(4), NCK1(5), NCK2(6), NRAS(4), NRG1(18), NRG2(3), NRG3(31), NRG4(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SRC(2), STAT5A(3), STAT5B(8), TGFA(1) 82290086 969 428 707 207 103 431 183 93 157 2 3.78e-07 1.000 1.000 148 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(26), ADCY8(48), ARAF(5), ATF4(2), BRAF(44), CACNA1C(61), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CREBBP(30), EP300(11), GNAQ(5), GRIA1(18), GRIA2(28), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18) 79663693 1081 425 886 258 128 520 220 70 139 4 9.96e-08 1.000 1.000 149 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(9), ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), ATM(53), ATR(26), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(10), CDC14B(3), CDC16(2), CDC20(8), CDC23(3), CDC25A(4), CDC25B(1), CDC25C(8), CDC27(7), CDC6(4), CDC7(6), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), CHEK1(7), CHEK2(10), CREBBP(30), CUL1(14), DBF4(6), E2F1(3), E2F2(5), E2F3(2), EP300(11), ESPL1(6), FZR1(3), GADD45A(2), GADD45B(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(8), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), PCNA(1), PKMYT1(3), PLK1(9), PRKDC(50), PTTG1(2), RB1(33), RBL1(7), RBL2(5), SFN(1), SKP1(4), SKP2(3), SMAD2(7), SMAD3(6), SMAD4(21), SMC1A(9), SMC1B(8), TFDP1(10), TGFB1(3), TGFB2(10), TP53(309), WEE1(4), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 109028105 1031 419 888 155 136 294 180 119 296 6 <1.00e-15 1.000 1.000 150 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(20), ACACB(28), AKT1(3), AKT2(7), AKT3(7), ARAF(5), BRAF(44), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CBL(10), CBLB(10), CBLC(1), CRK(1), CRKL(4), ELK1(3), EXOC7(4), FASN(18), FBP1(2), FBP2(2), FLOT1(1), FLOT2(4), FOXO1(5), G6PC(7), G6PC2(8), GCK(6), GRB2(6), GSK3B(4), GYS1(4), GYS2(8), HRAS(2), IKBKB(9), INPP5D(11), INSR(10), IRS1(20), IRS4(34), KRAS(169), LIPE(5), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MKNK1(4), MKNK2(2), NRAS(4), PCK1(21), PCK2(4), PDE3A(30), PDE3B(16), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PKLR(16), PPARGC1A(23), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R3A(48), PPP1R3B(1), PPP1R3C(3), PPP1R3D(5), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCI(11), PRKCZ(4), PRKX(3), PTPN1(3), PTPRF(15), PYGB(5), PYGL(6), PYGM(9), RAF1(6), RAPGEF1(7), RHEB(4), RHOQ(1), RPS6(3), RPS6KB1(3), RPS6KB2(3), SH2B2(6), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(12), SOS1(17), SOS2(13), SREBF1(3), TRIP10(2), TSC1(10), TSC2(13) 126813403 1138 419 935 319 140 510 241 93 150 4 0.00754 1.000 1.000 151 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(5), BID(2), BRAF(44), CASP3(5), CD244(14), CD247(1), CD48(5), FAS(4), FASLG(10), FCER1G(2), FCGR3A(9), FYN(8), GRB2(6), GZMB(6), HCST(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-E(2), HLA-G(5), HRAS(2), ICAM1(2), ICAM2(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), ITGAL(26), ITGB2(8), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KLRC1(5), KLRC2(2), KLRC3(5), KLRD1(2), KLRK1(4), KRAS(169), LAT(4), LCK(9), LCP2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(9), NCR2(3), NCR3(1), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NRAS(4), PAK1(9), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRF1(8), PRKCA(10), PRKCG(20), PTK2B(14), PTPN11(9), PTPN6(6), RAC2(2), RAF1(6), SH2D1A(3), SH2D1B(3), SH3BP2(10), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SYK(5), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TYROBP(2), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(8), VAV2(8), VAV3(32), ZAP70(9) 90825368 1023 417 815 237 111 479 212 79 138 4 6.50e-07 1.000 1.000 152 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(5), BRAF(44), CACNA1A(32), CRH(3), CRHR1(7), GNA11(4), GNA12(1), GNA13(6), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GNAZ(5), GRIA1(18), GRIA2(28), GRIA3(24), GRID2(54), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), IGF1(4), IGF1R(8), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(29), NOS3(12), NPR1(16), NPR2(6), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), RAF1(6), RYR1(111) 88226661 1207 411 1016 289 153 544 243 89 173 5 1.57e-08 1.000 1.000 153 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(9), ATM(53), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(8), CDC14A(10), CDC14B(3), CDC20(8), CDC25A(4), CDC25B(1), CDC25C(8), CDC6(4), CDC7(6), CDH1(6), CDK2(1), CDK4(3), CDKN1A(2), CDKN2A(22), CHEK1(7), CHEK2(10), DTX4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), EP300(11), ESPL1(6), GADD45A(2), GSK3B(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), HDAC8(1), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MPEG1(12), MPL(5), PCNA(1), PLK1(9), PRKDC(50), PTPRA(11), PTTG1(2), RB1(33), RBL1(7), SKP2(3), SMAD4(21), TBC1D8(9), TFDP1(10), TGFB1(3), TP53(309), WEE1(4) 88375531 917 405 774 132 112 267 147 102 283 6 <1.00e-15 1.000 1.000 154 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(9), ACTA2(1), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADM(1), ARRB1(2), ARRB2(4), ATF1(1), ATF2(10), ATF4(2), ATF5(2), ATP2A2(12), ATP2A3(7), CACNB3(1), CALCA(7), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CNN1(5), CORIN(25), CRH(3), CRHR1(7), DGKZ(5), ETS2(6), FOS(3), GABPA(6), GABPB2(1), GBA2(5), GJA1(11), GNAQ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), GUCA2B(2), GUCY1A3(16), IGFBP1(6), IGFBP2(4), IGFBP3(4), IGFBP4(1), IGFBP6(1), IL1B(1), IL6(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), MIB1(12), MYL2(8), MYL4(2), MYLK2(9), NFKB1(6), NOS1(29), NOS3(12), OXT(2), OXTR(4), PDE4B(14), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLCD1(4), PLCG1(7), PLCG2(18), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RAMP1(1), RAMP2(4), RAMP3(3), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SP1(6), TNXB(32), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4) 138778548 1649 405 1626 545 225 685 342 146 237 14 0.229 1.000 1.000 155 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(6), CADM1(7), CADM3(15), CD2(6), CD22(16), CD226(14), CD274(3), CD276(2), CD28(4), CD34(13), CD4(8), CD40(3), CD40LG(9), CD58(1), CD6(13), CD80(3), CD86(11), CD8A(4), CD8B(5), CD99(3), CDH1(6), CDH15(9), CDH2(35), CDH3(7), CDH4(23), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CNTN1(36), CNTN2(18), CNTNAP1(11), CNTNAP2(88), CTLA4(3), ESAM(2), F11R(3), GLG1(17), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(5), ICOSLG(3), ITGA4(38), ITGA6(12), ITGA8(59), ITGA9(6), ITGAL(26), ITGAM(24), ITGAV(14), ITGB1(6), ITGB2(8), ITGB7(2), ITGB8(15), JAM2(9), JAM3(4), L1CAM(42), MADCAM1(2), MAG(7), MPZ(2), MPZL1(3), NCAM1(30), NCAM2(28), NEGR1(14), NEO1(12), NFASC(46), NLGN1(34), NLGN2(10), NLGN3(14), NRCAM(35), NRXN1(109), NRXN2(25), NRXN3(49), OCLN(1), PDCD1(4), PDCD1LG2(4), PTPRC(41), PTPRF(15), PTPRM(14), PVRL1(16), PVRL3(7), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SELE(17), SELL(9), SELP(29), SELPLG(2), SIGLEC1(18), SPN(4), VCAM1(28), VCAN(104) 118538695 1551 402 1532 460 196 690 301 123 233 8 0.00651 1.000 1.000 156 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(7), AKT3(7), BCL10(4), CARD11(34), CBL(10), CBLB(10), CBLC(1), CD247(1), CD28(4), CD3D(2), CD3E(2), CD4(8), CD40LG(9), CD8A(4), CD8B(5), CDC42(1), CDK4(3), CHUK(7), CTLA4(3), FOS(3), FYN(8), GRAP2(13), GRB2(6), HRAS(2), ICOS(5), IFNG(7), IKBKB(9), IL10(2), IL2(7), IL4(1), IL5(2), ITK(16), JUN(3), KRAS(169), LAT(4), LCK(9), LCP2(10), MALT1(13), MAP3K8(4), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDCD1(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCQ(12), PTPN6(6), PTPRC(41), RASGRP1(3), RHOA(4), SOS1(17), SOS2(13), TEC(12), TNF(2), VAV1(8), VAV2(8), VAV3(32), ZAP70(9) 81304899 906 402 722 202 109 433 166 60 136 2 1.31e-06 1.000 1.000 157 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(16), AKT1(3), AKT2(7), AKT3(7), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CAPN1(2), CAPN2(5), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(14), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL3(4), IL3RA(8), IRAK1(6), IRAK2(6), IRAK3(6), IRAK4(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), NTRK1(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TP53(309), TRADD(2), TRAF2(5) 66856063 785 397 634 152 95 257 140 91 195 7 1.06e-07 1.000 1.000 158 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ASIP(1), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), CREB3L1(4), CREB3L2(8), CREB3L3(3), CREB3L4(2), CREBBP(30), CTNNB1(20), DCT(16), DVL1(5), DVL2(7), DVL3(13), EDN1(1), EDNRB(16), EP300(11), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GSK3B(4), HRAS(2), KIT(12), KITLG(6), KRAS(169), LEF1(12), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MC1R(2), MITF(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), POMC(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), TCF7(3), TCF7L1(6), TCF7L2(7), TYR(29), TYRP1(5), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6) 86816850 1069 397 890 295 165 478 219 72 133 2 5.36e-05 1.000 1.000 159 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), AKAP1(14), AKAP10(4), AKAP11(14), AKAP12(9), AKAP2(11), AKAP3(15), AKAP4(17), AKAP5(2), AKAP6(45), AKAP7(1), AKAP8(5), AKAP9(32), ARHGEF1(5), CALM1(3), CALM2(1), CHMP1B(1), GNA11(4), GNA12(1), GNA13(6), GNA14(2), GNA15(1), GNAI3(2), GNAL(5), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB5(7), GNG12(3), GNG13(5), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GNGT2(3), HRAS(2), IL18BP(1), ITPR1(20), KCNJ3(36), KRAS(169), NRAS(4), PALM2(7), PDE1A(17), PDE1B(13), PDE1C(28), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PLCB3(9), PPP3CA(14), PPP3CC(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(6), USP5(8) 93920207 994 389 826 275 110 465 216 73 124 6 0.00452 1.000 1.000 160 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCRL2(2), CHML(12), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CMKLR1(24), CNR1(15), CNR2(3), CX3CR1(11), CXCR3(3), CXCR4(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GPR17(8), GPR173(4), GPR174(18), GPR27(5), GPR35(8), GPR37(17), GPR4(7), GPR50(21), GPR6(8), GPR63(10), GPR83(12), GPR85(16), GPR87(4), GRPR(7), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC3R(16), MC4R(3), MC5R(22), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPN1SW(8), OPN3(3), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OR10A5(14), OR11A1(8), OR12D3(4), OR1C1(29), OR1F1(3), OR1Q1(11), OR2H1(16), OR5V1(6), OR7A5(6), OR7C1(5), OR8B8(12), OXTR(4), P2RY1(4), P2RY10(23), P2RY11(2), P2RY12(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY6(2), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), RGR(4), RHO(7), RRH(2), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SUCNR1(1), TBXA2R(1), TRHR(14) 97389921 1426 387 1406 501 220 598 312 142 150 4 0.0130 1.000 1.000 161 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(4), ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), ACVR1B(11), ACVR1C(11), BAIAP2(3), CDC42(1), CDH1(6), CREBBP(30), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTNND1(10), EGFR(86), EP300(11), ERBB2(12), FARP2(7), FER(16), FGFR1(4), FYN(8), IGF1R(8), INSR(10), IQGAP1(8), LEF1(12), LMO7(22), MAP3K7(10), MAPK1(2), MAPK3(3), MET(22), MLLT4(12), NLK(3), PARD3(15), PTPN1(3), PTPN6(6), PTPRB(50), PTPRF(15), PTPRJ(12), PTPRM(14), PVRL1(16), PVRL3(7), PVRL4(9), RAC2(2), RHOA(4), SMAD2(7), SMAD3(6), SMAD4(21), SNAI1(3), SNAI2(14), SORBS1(12), SRC(2), SSX2IP(3), TCF7(3), TCF7L1(6), TCF7L2(7), TGFBR1(7), TGFBR2(7), TJP1(15), VCL(8), WAS(8), WASF1(10), WASF2(3), WASF3(13), WASL(7), YES1(3) 96545997 845 379 776 207 110 282 162 103 188 0 0.00278 1.000 1.000 162 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(7), ACVR1B(11), ACVRL1(11), AKT1(3), AURKB(2), BMPR1A(4), BMPR2(10), BUB1(10), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(4), CLK1(3), CLK2(10), CLK4(4), COL4A3BP(2), CSNK2A1(5), CSNK2A2(2), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MAP3K10(4), MOS(9), NEK1(11), NEK3(4), OCRL(13), PAK4(6), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PIM2(7), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18), PLK3(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKG1(20), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KB1(3), STK11(87), TGFBR1(7), VRK1(6) 90226248 852 373 817 208 108 313 166 81 180 4 0.00346 1.000 1.000 163 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADK(2), ADSL(2), ADSS(6), ADSSL1(4), AK2(4), AK5(14), AK7(13), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), FHIT(2), GART(9), GDA(11), GMPR(5), GMPR2(1), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NME6(3), NME7(4), NPR1(16), NPR2(6), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(5), PAPSS2(10), PDE10A(31), PDE11A(24), PDE1A(17), PDE1C(28), PDE2A(11), PDE3B(16), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6G(3), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PDE9A(7), PFAS(9), PKLR(16), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PPAT(1), PRIM1(3), PRIM2(14), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), XDH(18), ZNRD1(1) 130985627 1077 372 1071 346 121 407 250 112 184 3 0.531 1.000 1.000 164 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(7), AKT3(7), BCL10(4), BLNK(2), BTK(25), CARD11(34), CD19(5), CD22(16), CD72(2), CD79A(2), CD79B(2), CD81(1), CHUK(7), CR2(20), FCGR2B(7), FOS(3), GSK3B(4), HRAS(2), IFITM1(2), IKBKB(9), INPP5D(11), JUN(3), KRAS(169), LILRB3(7), LYN(6), MALT1(13), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPN6(6), RAC2(2), RASGRP3(11), SYK(5), VAV1(8), VAV2(8), VAV3(32) 59550819 683 372 506 156 62 345 144 44 87 1 1.73e-05 1.000 1.000 165 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CBL(10), CBLB(10), CBLC(1), CCND1(3), CCND2(4), CCND3(1), CISH(1), CNTF(6), CNTFR(5), CREBBP(30), CRLF2(9), CSF2RA(8), CSF2RB(14), CSF3R(6), EP300(11), EPO(6), EPOR(2), GH1(7), GH2(7), GHR(19), GRB2(6), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL13RA2(13), IL15(6), IL15RA(2), IL19(2), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), IRF9(3), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), LIF(3), LIFR(14), MPL(5), MYC(4), OSM(5), OSMR(7), PIAS1(2), PIAS2(6), PIAS3(7), PIAS4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIM1(1), PRL(3), PRLR(18), PTPN11(9), PTPN6(6), SOCS2(3), SOCS4(1), SOCS5(8), SOCS7(2), SOS1(17), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), STAM(11), STAM2(5), STAT1(7), STAT2(6), STAT3(11), STAT4(11), STAT5A(3), STAT5B(8), STAT6(2), TPO(33), TSLP(8), TYK2(5) 116625933 974 368 958 303 91 392 216 105 169 1 0.716 1.000 1.000 166 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(9), ACTA2(1), ACTN2(43), ACTN4(6), DES(4), DMD(108), MYBPC1(21), MYBPC2(8), MYBPC3(15), MYH3(37), MYH6(42), MYH7(59), MYH8(73), MYL1(4), MYL2(8), MYL3(4), MYL4(2), MYL9(3), MYOM1(16), NEB(91), TCAP(1), TMOD1(5), TNNC2(2), TNNI1(3), TNNI2(4), TNNI3(6), TNNT1(3), TNNT2(6), TNNT3(5), TPM1(1), TPM2(3), TPM3(2), TPM4(2), TTN(654), VIM(5) 110040676 1256 368 1243 364 127 537 301 128 150 13 0.571 1.000 1.000 167 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(7), AKT3(7), BTK(25), FCER1A(9), FCER1G(2), FYN(8), GAB2(7), GRB2(6), HRAS(2), IL13(2), IL3(4), IL4(1), IL5(2), INPP5D(11), KRAS(169), LAT(4), LCP2(10), LYN(6), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MS4A2(7), NRAS(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PRKCA(10), PRKCD(7), PRKCE(5), RAC2(2), RAF1(6), SOS1(17), SOS2(13), SYK(5), TNF(2), VAV1(8), VAV2(8), VAV3(32) 57520397 672 356 495 147 61 335 145 40 89 2 4.23e-06 1.000 1.000 168 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(7), ACTN2(43), ACTN4(6), ARHGAP5(17), BCAR1(3), CD99(3), CDC42(1), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTNND1(10), CXCL12(3), CXCR4(6), CYBA(1), CYBB(11), ESAM(2), EZR(3), F11R(3), GNAI1(10), GNAI3(2), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), ITK(16), JAM2(9), JAM3(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(12), MMP2(24), MMP9(10), MSN(8), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NCF1(3), NCF2(8), NCF4(3), NOX1(8), NOX3(21), OCLN(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAC2(2), RAP1A(1), RAP1B(2), RAPGEF3(7), RAPGEF4(13), RHOA(4), RHOH(6), ROCK1(19), ROCK2(9), SIPA1(2), THY1(6), TXK(7), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCAM1(28), VCL(8) 99432479 935 355 912 277 113 406 197 78 139 2 0.0790 1.000 1.000 169 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(7), AKT3(7), CASP9(6), CDC42(1), HRAS(2), KDR(56), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPKAPK2(2), MAPKAPK3(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NOS3(12), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCA(10), PRKCG(20), PTGS2(12), PTK2(6), PXN(1), RAC2(2), RAF1(6), SH2D2A(10), SHC2(5), SPHK2(4), SRC(2), VEGFA(1) 57134632 645 352 464 158 62 339 132 53 58 1 0.000122 1.000 1.000 170 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(9), ACTN1(7), ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGEF6(21), ARHGEF7(6), BCAR1(3), BRAF(44), CAV1(1), CDC42(1), CDKN2A(22), CRK(1), CSE1L(7), DOCK1(15), EPHB2(10), FYN(8), GRB2(6), GRB7(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), MAP2K4(8), MAP2K7(7), MAP3K11(5), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MRAS(1), MYLK(26), MYLK2(9), P4HB(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PKLR(16), PLCG1(7), PLCG2(18), PTEN(11), PTK2(6), RAF1(6), RALA(5), RHO(7), ROCK1(19), ROCK2(9), SHC1(6), SOS1(17), SOS2(13), SRC(2), TLN1(15), TLN2(30), VASP(2), WAS(8), ZYX(6) 97934119 818 351 767 230 99 317 171 66 163 2 0.0833 1.000 1.000 171 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(21), AMY2A(6), AMY2B(11), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHX58(4), ENPP1(14), ENPP3(19), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), G6PC(7), G6PC2(8), GAA(12), GANC(3), GBA(7), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), IFIH1(10), LYZL1(5), MGAM(51), MOV10L1(11), NUDT5(2), NUDT8(2), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SI(117), SKIV2L2(15), SMARCA2(22), SMARCA5(5), TREH(1), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UXS1(6) 99524772 876 344 869 238 93 371 192 83 137 0 0.0583 1.000 1.000 172 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG6(1), ALG8(3), ALG9(5), B3GNT1(3), B3GNT2(4), B3GNT6(5), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), CHPF(10), CHST1(17), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST2(14), CHST3(1), CHST4(3), CHST6(7), CHST7(2), CHSY1(5), DAD1(2), DDOST(1), DPAGT1(5), EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), FUT11(5), FUT8(7), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GANAB(9), GCNT1(8), GCNT3(2), GCNT4(9), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), NDST1(6), NDST2(6), NDST3(16), NDST4(36), OGT(19), RPN1(3), RPN2(4), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST6GAL1(4), ST6GALNAC1(8), STT3B(4), UST(5), WBSCR17(33), XYLT1(44), XYLT2(3) 88486212 806 341 797 271 127 297 187 85 108 2 0.672 1.000 1.000 173 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(34), ABCA12(39), ABCA13(86), ABCA2(21), ABCA3(11), ABCA4(19), ABCA5(23), ABCA6(26), ABCA7(18), ABCA8(25), ABCA9(26), ABCB1(45), ABCB10(11), ABCB11(28), ABCB4(19), ABCB5(60), ABCB6(4), ABCB7(12), ABCB8(11), ABCB9(7), ABCC1(14), ABCC10(11), ABCC11(38), ABCC12(22), ABCC2(11), ABCC3(13), ABCC4(21), ABCC5(14), ABCC6(9), ABCC8(25), ABCC9(30), ABCD1(2), ABCD2(14), ABCD3(2), ABCD4(5), ABCG1(8), ABCG2(14), ABCG4(16), ABCG5(19), ABCG8(19), CFTR(11), TAP1(1), TAP2(8) 94274026 869 341 863 263 85 335 202 88 155 4 0.109 1.000 1.000 174 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADK(2), ADSL(2), ADSS(6), AK2(4), AK5(14), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), ATP1B1(6), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5F1(3), ATP5G3(2), ATP5J2(3), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(11), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NPR1(16), NPR2(6), NT5E(5), NT5M(3), NUDT2(3), PAICS(1), PAPSS1(5), PAPSS2(10), PDE1A(17), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6B(15), PDE6C(12), PDE6G(3), PDE7B(6), PDE8A(3), PDE9A(7), PFAS(9), PKLR(16), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), PPAT(1), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RRM1(6), RRM2(6) 102556225 846 333 841 281 101 313 191 90 149 2 0.678 1.000 1.000 175 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(3), CALM2(1), CALML3(3), CALML6(1), CDIPT(1), CDS1(3), CDS2(4), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5D(11), INPP5E(2), INPPL1(11), ITPK1(1), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), OCRL(13), PI4KA(17), PI4KB(10), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PRKCA(10), PRKCG(20), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9) 99499360 816 332 800 230 102 309 184 72 145 4 0.0651 1.000 1.000 176 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(7), BCAR1(3), CAPN1(2), CAPN10(8), CAPN11(13), CAPN2(5), CAPN3(8), CAPN5(12), CAPN6(25), CAPN7(7), CAPN9(5), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CRK(1), CSK(2), DOCK1(15), FYN(8), GIT2(5), GRB2(6), ILK(1), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAPK10(6), MAPK12(2), MAPK4(9), MAPK6(4), MAPK7(7), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PDPK1(3), PIK3R2(7), PTK2(6), PXN(1), RAC2(2), RAP1B(2), RAPGEF1(7), RHO(7), ROCK1(19), ROCK2(9), SDCCAG8(12), SEPP1(1), SHC1(6), SHC3(8), SORBS1(12), SOS1(17), SRC(2), TLN1(15), TNS1(23), VASP(2), VAV2(8), VAV3(32), VCL(8), ZYX(6) 107108167 915 332 904 268 88 386 192 75 170 4 0.108 1.000 1.000 177 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(24), BDKRB1(1), BDKRB2(3), C1QA(7), C1QB(11), C1QC(5), C1R(4), C1S(4), C2(10), C3(13), C3AR1(11), C4BPA(6), C4BPB(1), C5(6), C5AR1(7), C6(29), C7(39), C8A(18), C8B(20), C9(20), CD46(3), CD55(3), CFB(4), CFH(46), CFI(6), CPB2(6), CR1(34), CR2(20), F10(5), F11(13), F12(4), F13A1(29), F13B(28), F2(9), F2R(10), F3(3), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), KNG1(9), MASP1(13), MASP2(8), MBL2(13), PLAT(12), PLAUR(4), PLG(32), PROC(4), PROS1(30), SERPINA1(4), SERPINA5(18), SERPINC1(5), SERPIND1(3), SERPINE1(14), SERPINF2(2), SERPING1(7), TFPI(4), THBD(4), VWF(32) 72761103 854 331 843 243 73 400 155 75 149 2 0.157 1.000 1.000 178 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(10), CD14(1), CD19(5), CD1A(23), CD1B(17), CD1C(15), CD1D(10), CD1E(27), CD2(6), CD22(16), CD33(13), CD34(13), CD36(4), CD37(2), CD38(4), CD3D(2), CD3E(2), CD4(8), CD44(7), CD5(7), CD55(3), CD8A(4), CD8B(5), CD9(3), CR1(34), CR2(20), CSF1(1), CSF1R(18), CSF2RA(8), CSF3R(6), DNTT(6), EPO(6), EPOR(2), FCER2(2), FCGR1A(5), FLT3(24), FLT3LG(2), GP5(8), HLA-DRA(3), HLA-DRB1(5), IL11RA(1), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL2RA(6), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL7(2), IL7R(21), IL9R(16), ITGA1(14), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGAM(24), ITGB3(13), KIT(12), KITLG(6), MME(20), MS4A1(11), TFRC(6), THPO(7), TNF(2), TPO(33) 65727396 713 312 700 232 68 297 133 69 146 0 0.703 1.000 1.000 179 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(28), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ADIPOR1(6), ADIPOR2(3), AKT1(3), AKT2(7), AKT3(7), CAMKK1(4), CAMKK2(3), CD36(4), CHUK(7), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), G6PC(7), G6PC2(8), IKBKB(9), IRS1(20), IRS4(34), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), MAPK10(6), MAPK8(2), MAPK9(8), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NPY(4), PCK1(21), PCK2(4), POMC(4), PPARA(4), PPARGC1A(23), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKCQ(12), PTPN11(9), RELA(3), RXRA(1), RXRB(3), RXRG(18), SLC2A1(1), SLC2A4(4), STAT3(11), STK11(87), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5), TYK2(5) 65718655 589 311 568 181 66 202 106 62 153 0 0.474 1.000 1.000 180 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(7), AKT3(7), CASP8(6), CCL4(2), CD14(1), CD40(3), CD80(3), CD86(11), CHUK(7), CXCL10(1), CXCL11(1), CXCL9(4), FADD(2), FOS(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IKBKB(9), IKBKE(9), IL12A(2), IL12B(3), IL1B(1), IL6(2), IRAK1(6), IRAK4(4), IRF5(1), IRF7(3), JUN(3), LBP(8), LY96(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K7(10), MAP3K8(4), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), RELA(3), RIPK1(11), SPP1(5), STAT1(7), TBK1(4), TICAM1(3), TLR1(9), TLR2(10), TLR3(4), TLR4(64), TLR5(8), TLR6(11), TLR7(17), TLR8(16), TLR9(9), TNF(2), TOLLIP(2), TRAF3(4), TRAF6(6) 71758645 601 307 587 191 54 241 133 73 100 0 0.572 1.000 1.000 181 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(7), ACVR1B(11), ACVR1C(11), ACVR2A(5), ACVR2B(4), ACVRL1(11), AMHR2(6), BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BMPR1A(4), BMPR1B(7), BMPR2(10), CHRD(13), COMP(4), CREBBP(30), CUL1(14), DCN(5), E2F4(5), E2F5(1), EP300(11), FST(5), GDF5(12), GDF6(10), GDF7(5), ID1(1), ID2(4), ID3(3), IFNG(7), INHBA(31), INHBB(4), INHBC(4), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(61), MAPK1(2), MAPK3(3), MYC(4), NODAL(2), NOG(1), PITX2(8), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), RBL1(7), RBL2(5), RHOA(4), ROCK1(19), ROCK2(9), RPS6KB1(3), RPS6KB2(3), SKP1(4), SMAD1(7), SMAD2(7), SMAD3(6), SMAD4(21), SMAD5(1), SMAD6(2), SMAD9(4), SMURF1(8), SMURF2(4), SP1(6), TFDP1(10), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNF(2), ZFYVE16(7), ZFYVE9(14) 79353108 657 304 652 180 106 234 140 65 111 1 0.0539 1.000 1.000 182 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(7), AKT3(7), ASAH1(3), BRAF(44), DAG1(3), DRD2(26), EGFR(86), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PI3(1), PIK3CB(8), PITX2(8), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), RAF1(6), RGS20(8), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT3(11) 46979625 523 302 443 116 51 187 113 64 106 2 0.00251 1.000 1.000 183 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(10), BCL2(5), CABIN1(10), CALM1(3), CALM2(1), CAMK2B(16), CAMK4(16), CD3E(2), CD69(2), CDKN1A(2), CNR1(15), CREBBP(30), CSNK2A1(5), CTLA4(3), EGR2(4), EGR3(1), EP300(11), FCER1A(9), FCGR3A(9), FOS(3), FOSL1(4), GATA3(12), GATA4(7), GSK3A(1), GSK3B(4), HRAS(2), ICOS(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL13(2), IL1B(1), IL2(7), IL2RA(6), IL3(4), IL4(1), IL6(2), ITK(16), JUNB(1), KPNA5(4), MAP2K7(7), MAPK14(4), MAPK8(2), MAPK9(8), MEF2A(2), MEF2B(2), MEF2D(4), MYF5(12), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB2(5), NFKBIB(3), NFKBIE(2), NPPB(3), NUP214(26), OPRD1(2), P2RX7(6), PAK1(9), PIN1(1), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPRC(41), RELA(3), RPL13A(2), SFN(1), SLA(6), SP1(6), SP3(6), TGFB1(3), TNF(2), TRAF2(5), TRPV6(25), VAV1(8), VAV2(8), VAV3(32), XPO5(6) 72801598 586 297 581 183 67 223 121 48 125 2 0.434 1.000 1.000 184 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(4), ALG6(1), CCKBR(24), CCR2(6), CCR3(4), CCR5(4), CELSR1(17), CELSR2(22), CELSR3(36), CHRM2(39), CHRM3(27), CIDEB(2), CXCR3(3), DRD4(2), EDNRA(3), EMR2(13), EMR3(10), F2R(10), FSHR(37), GHRHR(5), GNRHR(5), GPR116(11), GPR132(6), GPR133(18), GPR135(4), GPR143(2), GPR17(8), GPR18(4), GPR55(9), GPR56(6), GPR61(8), GPR84(4), GRM1(48), GRPR(7), HRH4(5), LGR6(22), LPHN2(47), LPHN3(78), NTSR1(10), OR2M4(33), P2RY11(2), P2RY13(1), PTGFR(12), SMO(17), SSTR2(4), TAAR5(11), TSHR(22), VN1R1(2) 52700176 675 297 669 208 99 272 140 67 95 2 0.0223 1.000 1.000 185 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CDC42(1), CDK2(1), CDKN1B(5), CDKN2A(22), CREB1(2), CREB5(18), EBP(3), ERBB4(51), F2RL2(12), GAB1(7), GADD45A(2), GRB2(6), GSK3A(1), GSK3B(4), IFI27(1), IGF1(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), MET(22), MYC(4), NOLC1(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PPP1R13B(7), PREX1(40), PTEN(11), PTK2(6), PTPN1(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SLC2A4(4), SOS1(17), SOS2(13), TSC1(10), TSC2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 61212291 557 294 533 133 72 231 108 39 107 0 0.00204 1.000 1.000 186 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(9), AKT1(3), BDKRB2(3), CALM1(3), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(16), FLT1(31), FLT4(20), KDR(56), NOS3(12), PDE2A(11), PDE3A(30), PDE3B(16), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKG1(20), PRKG2(15), RYR2(359), SLC7A1(5), SYT1(6), TNNI1(3) 32393146 649 288 629 183 62 297 127 63 91 9 0.0364 1.000 1.000 187 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(33), ASH2L(2), CARM1(4), CTCFL(21), DOT1L(14), EED(8), EHMT1(15), EHMT2(9), EZH1(4), EZH2(11), FBXO11(5), HCFC1(24), HSF4(1), JMJD4(3), JMJD6(3), KDM6A(12), MEN1(6), NSD1(23), OGT(19), PAXIP1(7), PPP1CA(2), PPP1CB(4), PPP1CC(1), PRDM2(21), PRDM7(6), PRDM9(82), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), RBBP5(3), SATB1(10), SETD1A(18), SETD2(39), SETD7(2), SETD8(1), SETDB1(11), SETDB2(13), SETMAR(5), SMYD3(10), STK38(3), SUV39H1(1), SUV39H2(4), SUV420H1(16), WHSC1(12), WHSC1L1(8) 95093196 527 278 521 148 56 203 125 45 92 6 0.453 1.000 1.000 188 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(7), AKT3(7), BRAF(44), CAB39(2), DDIT4(4), EIF4B(7), FIGF(4), HIF1A(2), IGF1(4), MAPK1(2), MAPK3(3), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PRKAA1(6), PRKAA2(8), RHEB(4), RICTOR(25), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), STK11(87), TSC1(10), TSC2(13), ULK1(8), ULK2(9), ULK3(2), VEGFA(1), VEGFB(2), VEGFC(21) 41941776 444 278 390 88 44 166 86 39 107 2 0.000285 1.000 1.000 189 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(10), BRAF(44), CHUK(7), CREB1(2), DAXX(8), ELK1(3), FOS(3), GRB2(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP3K9(17), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK4(9), MAPK6(4), MAPK7(7), MAPK8(2), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MKNK2(2), MYC(4), NFKB1(6), NFKBIA(4), PAK1(9), PAK2(3), RAF1(6), RELA(3), RIPK1(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KB1(3), RPS6KB2(3), SHC1(6), SP1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5) 75906247 525 276 496 137 57 188 109 45 125 1 0.0711 1.000 1.000 190 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5E(2), INPPL1(11), IPMK(11), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(7), MINPP1(3), MIOX(2), OCRL(13), PI4KA(17), PI4KB(10), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9) 59264272 477 269 463 136 55 186 114 41 79 2 0.139 1.000 1.000 191 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(33), AR(10), ASAH1(3), BRAF(44), CAMP(4), CCL13(3), CCL15(5), CCL16(4), DAG1(3), EGFR(86), GNA11(4), GNA15(1), GNAI1(10), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), MAPK10(6), MAPK14(4), PHKA2(14), PIK3CA(30), PIK3CD(4), PIK3R1(4), PITX2(8), PTX3(3), RAF1(6), SRC(2) 42843438 439 268 351 81 39 150 97 49 103 1 0.000151 1.000 1.000 192 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(9), ADAM17(8), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CASP3(5), CDC42(1), CHUK(7), CSK(2), CXCL1(1), EGFR(86), F11R(3), GIT1(3), IGSF5(6), IKBKB(9), JAM2(9), JAM3(4), JUN(3), LYN(6), MAP2K4(8), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK8(2), MAPK9(8), MET(22), NFKB1(6), NFKB2(5), NFKBIA(4), NOD1(7), PAK1(9), PLCG1(7), PLCG2(18), PTPN11(9), PTPRZ1(72), RELA(3), SRC(2), TCIRG1(2), TJP1(15) 56419102 450 267 394 127 44 136 78 66 125 1 0.439 1.000 1.000 193 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(9), AGTR2(6), ATP8A1(7), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(6), CXCR6(2), EDNRA(3), EDNRB(16), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GNRHR(5), GRPR(7), LHCGR(14), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), NMBR(8), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), TAC4(1), TACR1(4), TACR2(2), TACR3(15), TRHR(14), TSHR(22) 42039386 562 266 554 217 89 233 122 53 64 1 0.475 1.000 1.000 194 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGAP1(5), ARHGAP4(14), ARHGEF11(24), BTK(25), CDC42(1), CFL2(3), GDI1(6), GDI2(1), INPPL1(11), ITPR1(20), ITPR2(40), ITPR3(21), LIMK1(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3CG(33), PIK3R1(4), PITX2(8), PPP1R13B(7), PTEN(11), RACGAP1(7), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), SAG(5), WASF1(10), WASL(7) 56336808 479 261 462 127 71 181 96 37 94 0 0.0271 1.000 1.000 195 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(7), AKT3(7), BCL2(5), BCR(11), BLNK(2), BTK(25), CD19(5), CD22(16), CD81(1), CR2(20), CSK(2), DAG1(3), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), INPP5D(11), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(9), NFATC2(15), NR0B2(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PTPRC(41), RAF1(6), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8) 59335258 450 259 431 140 55 166 107 34 88 0 0.416 1.000 1.000 196 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(5), CDC40(4), CLK2(10), CLK3(2), CLK4(4), COL2A1(24), CPSF1(14), CPSF2(8), CPSF3(6), CSTF1(7), CSTF2(3), CSTF2T(7), CSTF3(7), DDIT3(2), DDX1(9), DDX20(4), DHX15(7), DHX16(7), DHX38(9), DHX8(14), DHX9(12), DICER1(15), DNAJC8(4), FUS(5), GIPC1(6), LSM2(1), LSM7(2), METTL3(3), NCBP1(3), NCBP2(3), NONO(6), NXF1(11), PABPN1(5), PAPOLA(11), POLR2A(11), PPM1G(6), PRPF18(3), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(10), PSKH1(3), PTBP1(4), PTBP2(9), RBM17(4), RBM5(6), RNGTT(10), RNMT(8), RNPS1(1), SF3A1(10), SF3A2(1), SF3A3(2), SF3B1(15), SF3B2(14), SF3B4(8), SF3B5(3), SNRPA(1), SNRPA1(1), SNRPB(3), SNRPB2(1), SNRPD1(2), SNRPD3(4), SNRPE(1), SNRPG(2), SNRPN(15), SNURF(2), SPOP(4), SRPK1(5), SRPK2(6), SRRM1(4), SUPT5H(9), U2AF1(12), U2AF2(6), XRN2(8) 85058513 473 258 457 127 70 162 100 53 88 0 0.231 1.000 1.000 197 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(21), AMY2A(6), AMY2B(11), ENPP1(14), ENPP3(19), G6PC(7), GAA(12), GANAB(9), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), MGAM(51), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RNPC3(1), SI(117), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UXS1(6) 45835022 499 251 495 132 58 224 102 42 73 0 0.0372 1.000 1.000 198 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(12), ADCY6(10), ADCY8(48), CACNA1A(32), CACNA1B(39), GNAS(29), GNAT3(6), GNB1(2), GNB3(5), GNG13(5), GNG3(1), GRM4(21), ITPR3(21), KCNB1(28), PDE1A(17), PLCB2(12), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), SCNN1A(2), SCNN1B(6), SCNN1G(8), TAS1R1(5), TAS1R2(28), TAS1R3(6), TAS2R1(20), TAS2R10(2), TAS2R13(2), TAS2R14(4), TAS2R16(15), TAS2R3(2), TAS2R38(9), TAS2R39(5), TAS2R4(3), TAS2R40(7), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R5(3), TAS2R50(1), TAS2R60(9), TAS2R7(3), TAS2R9(3), TRPM5(11) 45162780 484 250 476 163 86 193 118 30 57 0 0.143 1.000 1.000 199 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(9), AGT(4), AKT1(3), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK1G(2), CAMK4(16), CREBBP(30), CSNK1A1(2), EDN1(1), ELSPBP1(8), F2(9), GATA4(7), GSK3B(4), HAND1(5), HAND2(10), HRAS(2), IGF1(4), LIF(3), MAP2K1(10), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MEF2C(6), MYH2(77), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKX2-5(8), NPPA(3), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAF1(6), RPS6KB1(3), SYT1(6) 40746036 384 250 366 98 57 160 81 28 57 1 0.0185 1.000 1.000 200 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(4), AKR1D1(12), ARSD(6), ARSE(5), CARM1(4), CYP11B1(27), CYP11B2(24), CYP19A1(4), HSD11B1(9), HSD17B1(2), HSD17B12(4), HSD17B2(6), HSD17B3(3), HSD17B7(3), HSD3B1(6), HSD3B2(15), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), SULT2B1(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), WBSCR22(3) 40649497 440 248 434 125 40 196 106 41 56 1 0.122 1.000 1.000 201 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), ITPA(1), NME6(3), NME7(4), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PRIM1(3), PRIM2(14), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), TK1(1), TK2(1), TXNRD1(7), TXNRD2(2), TYMS(3), UCK2(10), UMPS(4), UPB1(2), UPP1(6), UPP2(6), UPRT(5), ZNRD1(1) 64981879 430 247 429 121 51 169 101 38 68 3 0.191 1.000 1.000 202 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BTRC(12), CSNK1A1(2), CSNK1A1L(14), CSNK1D(7), CSNK1E(6), CSNK1G1(4), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(2), GLI1(17), GLI2(28), GLI3(39), GSK3B(4), HHIP(4), IHH(3), LRP2(88), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), PTCH1(16), PTCH2(8), RAB23(1), SHH(2), SMO(17), STK36(12), SUFU(2), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6), ZIC2(3) 48461340 475 245 468 135 96 190 101 33 55 0 0.0389 1.000 1.000 203 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AGK(6), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AKR1A1(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CEL(8), DAK(4), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), GK(7), GK2(10), GLA(9), GLB1(3), GPAM(6), LCT(50), LIPA(2), LIPC(9), LIPF(8), LIPG(11), LPL(8), MGLL(2), PNLIP(19), PNLIPRP1(14), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1) 46900800 443 237 435 120 52 181 95 37 77 1 0.0378 1.000 1.000 204 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1C1(4), AKR1C2(2), AKR1C3(5), AKR1C4(4), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), CYP1A1(9), CYP1A2(3), CYP1B1(5), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2F1(3), CYP2S1(3), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHDH(3), EPHX1(7), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), MGST1(1), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14) 46469574 440 237 435 124 37 200 95 35 73 0 0.108 1.000 1.000 205 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(7), AKT3(7), BCR(11), BTK(25), CD19(5), CDKN2A(22), DAPP1(3), FLOT1(1), FLOT2(4), GAB1(7), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), NR0B2(3), PDK1(6), PIK3CA(30), PITX2(8), PLCG2(18), PPP1R13B(7), PREX1(40), PTEN(11), PTPRC(41), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SAG(5), SYK(5), TEC(12), VAV1(8) 44383020 399 236 383 91 49 152 89 26 83 0 0.00211 1.000 1.000 206 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(8), ACOX1(5), ACOX2(3), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ANGPTL4(2), APOA1(3), APOA2(1), APOA5(10), APOC3(2), AQP7(7), CD36(4), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP27A1(5), CYP4A11(8), CYP4A22(1), CYP7A1(8), CYP8B1(4), EHHADH(13), FABP2(1), FABP3(4), FABP4(2), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(7), GK2(10), HMGCS2(7), ILK(1), LPL(8), ME1(3), MMP1(11), NR1H3(4), OLR1(8), PCK1(21), PCK2(4), PDPK1(3), PLTP(7), PPARA(4), PPARD(6), PPARG(8), RXRA(1), RXRB(3), RXRG(18), SCD(3), SCP2(4), SLC27A1(4), SLC27A2(4), SLC27A4(4), SLC27A5(7), SLC27A6(24), SORBS1(12), UBC(14), UCP1(3) 52667188 406 234 404 122 51 159 79 50 67 0 0.292 1.000 1.000 207 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2) 42267861 369 234 359 106 42 154 70 42 61 0 0.144 1.000 1.000 208 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2) 42267861 369 234 359 106 42 154 70 42 61 0 0.144 1.000 1.000 209 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), F10(5), F11(13), F12(4), F2(9), F2R(10), F5(40), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), PROC(4), PROS1(30), SERPINC1(5), SERPING1(7) 35804097 443 234 440 122 32 230 77 32 71 1 0.437 1.000 1.000 210 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(6), ACTG2(10), ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), CDC42(1), CFL2(3), FLNA(31), FLNC(55), FSCN1(4), FSCN2(1), FSCN3(14), GDI1(6), GDI2(1), LIMK1(3), MYH2(77), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PFN1(1), PFN2(1), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), VASP(2), WASF1(10), WASL(7) 38011947 392 233 384 132 55 161 69 41 66 0 0.450 1.000 1.000 211 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(5), CHUK(7), DAXX(8), EGF(13), EGFR(86), ETS1(8), ETS2(6), FOS(3), HOXA7(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(4), PPP2CA(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), RAF1(6), RELA(3), RIPK1(11), SP1(6), TNF(2), TNFRSF1B(2), TRAF2(5) 39438567 338 229 286 94 32 98 61 57 88 2 0.460 1.000 1.000 212 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(33), AXIN1(7), CCND1(3), CCND2(4), CCND3(1), CSNK1E(6), CTNNB1(20), DVL1(5), DVL2(7), DVL3(13), FBXW2(4), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LDLR(9), MAPK10(6), MAPK9(8), MYC(4), PAFAH1B1(1), PPP2R5C(1), PPP2R5E(5), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), RHOA(4), SFRP4(7), TCF7(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4) 47839156 414 229 402 108 87 152 73 30 70 2 0.00959 1.000 1.000 213 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(8), APH1A(3), CREBBP(30), CTBP1(2), DLL1(5), DLL3(6), DLL4(2), DTX1(10), DTX2(6), DTX3(6), DTX3L(3), DTX4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), HDAC1(4), HDAC2(8), HES1(2), JAG1(16), JAG2(7), LFNG(3), MAML1(9), MAML2(10), MAML3(9), MFNG(1), NCOR2(30), NCSTN(13), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), NUMB(3), NUMBL(3), PSEN1(6), PSEN2(9), PSENEN(2), PTCRA(8), RBPJ(3), RBPJL(5), RFNG(1), SNW1(3) 54216501 390 224 389 114 63 143 81 38 64 1 0.147 1.000 1.000 214 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(5), APOA1(3), APOA2(1), CD36(4), CITED2(3), CPT1B(6), CREBBP(30), DUSP1(1), EHHADH(13), EP300(11), HSD17B4(8), JUN(3), LPL(8), MAPK1(2), MAPK3(3), ME1(3), MRPL11(1), MYC(4), NCOA1(18), NCOR1(23), NCOR2(30), NFKBIA(4), NR0B2(3), NR1H3(4), NR2F1(7), NRIP1(13), PDGFA(5), PIK3CA(30), PIK3R1(4), PPARA(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PTGS2(12), RB1(33), RELA(3), RXRA(1), SP1(6), STAT5A(3), STAT5B(8), TNF(2) 50606647 356 223 342 94 48 122 70 34 81 1 0.108 1.000 1.000 215 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(4), ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), G6PC2(8), GALM(2), GAPDH(5), GAPDHS(10), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGAM4(6), PGK1(4), PGK2(27), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 46692040 398 221 393 118 58 163 74 37 66 0 0.133 1.000 1.000 216 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(6), APAF1(10), ARHGDIB(2), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), GSN(4), LMNA(2), LMNB1(5), LMNB2(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK8(2), MDM2(5), NFKB1(6), NFKBIA(4), NUMA1(16), PAK2(3), PRKCD(7), PRKDC(50), PSEN1(6), PSEN2(9), PTK2(6), RASA1(11), RB1(33), RELA(3), RIPK1(11), SPTAN1(21), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5) 55298179 348 218 346 92 27 102 76 41 102 0 0.372 1.000 1.000 217 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MIOX(2), OCRL(13), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18) 35920520 342 217 329 87 44 136 75 30 56 1 0.0435 1.000 1.000 218 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(9), CRK(1), CRKL(4), DOCK1(15), ELK1(3), FOS(3), GAB1(7), GRB2(6), HGF(54), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(2), MET(22), PAK1(9), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAF1(6), RAP1A(1), RAP1B(2), RASA1(11), SOS1(17), SRC(2), STAT3(11) 35495397 313 217 292 93 23 115 67 43 65 0 0.700 1.000 1.000 219 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(3), APC(33), ASAH1(3), CAMP(4), CAV3(3), DAG1(3), DLG4(7), EPHB2(10), GNAI1(10), GNAQ(5), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PITX2(8), PTX3(3), RHO(7), RYR1(111) 36904482 342 217 337 96 60 118 80 25 57 2 0.0827 1.000 1.000 220 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(4), CD3D(2), CSK(2), CTLA4(3), DAG1(3), EPHB2(10), FBXW7(15), GRAP2(13), GRB2(6), ITK(16), ITPKA(2), ITPKB(7), LAT(4), LCK(9), LCP2(10), MAPK1(2), NCK1(5), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLCG1(7), PTPRC(41), RAF1(6), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), SOS1(17), SOS2(13), VAV1(8), ZAP70(9) 44571429 361 215 351 113 50 141 66 25 79 0 0.493 1.000 1.000 221 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(134), B3GALT4(1), CDR1(15), DGKI(35), IL6ST(3), MRPL19(1), PIGK(3), RPL10(4), RPL11(2), RPL13A(2), RPL14(2), RPL15(1), RPL17(2), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL37(2), RPL3L(8), RPL4(5), RPL41(1), RPL5(8), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPLP0(2), RPLP1(1), RPLP2(3), RPS10(3), RPS11(1), RPS13(1), RPS14(1), RPS15(2), RPS16(4), RPS18(2), RPS19(1), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), RPS7(1), RPSA(1), SLC36A2(6), UBA52(1), UBC(14) 41821993 371 214 364 103 38 175 73 27 56 2 0.164 1.000 1.000 222 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AKR1A1(1), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), CEL(8), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), GK(7), GLA(9), GLB1(3), LCT(50), LIPC(9), LIPF(8), LIPG(11), LPL(8), PNLIP(19), PNLIPRP1(14), PPAP2A(2), PPAP2B(3), PPAP2C(1) 38463524 380 213 374 91 47 155 78 31 69 0 0.00291 1.000 1.000 223 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(13), F12(4), F13B(28), F2(9), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), LPA(47), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14), SERPINF2(2), VWF(32) 28374054 380 210 374 103 24 171 80 38 66 1 0.179 1.000 1.000 224 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), AFMID(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(3), CYP1B1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), INMT(8), KMO(9), KYNU(17), LCMT1(5), LCMT2(7), LNX1(9), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NFX1(5), OGDH(10), OGDHL(35), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TDO2(9), TPH1(8), TPH2(16), WARS(6), WARS2(7), WBSCR22(3) 48745420 383 210 376 110 53 128 82 50 70 0 0.160 1.000 1.000 225 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(3), AKT2(7), AKT3(7), BRD4(7), CBL(10), CDC42(1), CDKN2A(22), F2RL2(12), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), LNPEP(5), MAPK1(2), MAPK3(3), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTEN(11), PTPN1(3), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SERPINB6(3), SFN(1), SHC1(6), SLC2A4(4), SORBS1(12), SOS1(17), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 47146229 337 210 318 83 41 138 80 23 54 1 0.0397 1.000 1.000 226 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), HSD3B7(7), NSD1(23), OGDH(10), OGDHL(35), PIPOX(2), PLOD1(5), PLOD2(12), PLOD3(10), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SETD1A(18), SETD7(2), SETDB1(11), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(4), TMLHE(9) 46424015 336 209 332 93 50 131 73 33 47 2 0.0900 1.000 1.000 227 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(86), ELK1(3), GNAS(29), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), IGF1R(8), ITGB1(6), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MYC(4), NGFR(5), PDGFRA(41), PPP2CA(1), PTPRR(16), RAF1(6), RPS6KA1(6), RPS6KA5(10), SHC1(6), SOS1(17), SRC(2), STAT3(11) 26484085 305 208 248 64 35 104 51 52 62 1 0.0160 1.000 1.000 228 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(3), ATF1(1), BRAF(44), CAMP(4), CREB1(2), CREB5(18), CREBBP(30), CRKL(4), DAG1(3), EGR1(6), EGR2(4), EGR3(1), EGR4(3), ELK1(3), FRS2(10), GNAQ(5), JUN(3), MAP1B(29), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), NTRK1(14), OPN1LW(9), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTPN11(9), RPS6KA3(6), SHC1(6), SRC(2), TH(7) 40873459 335 208 299 83 50 137 74 20 52 2 0.00707 1.000 1.000 229 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CHPT1(3), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), ESCO1(10), ESCO2(4), ETNK1(5), GNPAT(5), GPAM(6), GPD1(3), GPD1L(4), GPD2(9), LCAT(6), NAT6(1), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1), PTDSS1(10), PTDSS2(3) 52161680 368 207 361 118 42 131 92 34 67 2 0.721 1.000 1.000 230 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), EGF(13), EGFR(86), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3) 30286601 275 204 211 50 24 75 45 55 76 0 0.0117 1.000 1.000 231 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(17), CALCR(27), CALCRL(18), CD97(12), CRHR1(7), ELTD1(39), EMR1(24), EMR2(13), GHRHR(5), GIPR(3), GLP1R(11), GLP2R(17), GPR64(14), LPHN1(7), LPHN2(47), LPHN3(78), SCTR(5), VIPR1(2), VIPR2(3) 21308194 349 203 346 101 34 140 68 44 62 1 0.131 1.000 1.000 232 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(3), CALM2(1), CD3D(2), CD3E(2), ELK1(3), FOS(3), FYN(8), GRB2(6), HRAS(2), JUN(3), LAT(4), LCK(9), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PIK3CA(30), PIK3R1(4), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), PTPN7(1), RAF1(6), RASA1(11), RELA(3), SHC1(6), SOS1(17), SYT1(6), VAV1(8), ZAP70(9) 38495246 274 202 256 78 39 105 49 25 56 0 0.257 1.000 1.000 233 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(2), ALAS2(6), BLVRA(3), BLVRB(2), COX10(4), CP(11), CPOX(4), EARS2(5), EPRS(27), FECH(4), FTH1(2), FTMT(11), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), MMAB(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UROS(2) 34202749 322 201 320 96 21 153 77 25 46 0 0.443 1.000 1.000 234 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), HRH1(5), HRH2(17), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11) 20500751 369 201 364 126 55 168 70 29 45 2 0.0457 1.000 1.000 235 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHFR(2), DHX58(4), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), FPGS(3), GCH1(3), GGH(9), IFIH1(10), MOV10L1(11), NUDT5(2), NUDT8(2), PTS(1), QDPR(7), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SKIV2L2(15), SMARCA2(22), SMARCA5(5), SPR(3) 50269127 313 199 311 95 33 102 82 35 61 0 0.533 1.000 1.000 236 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(25), CALM1(3), CALM2(1), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PAK2(3), PIK3CA(30), PIK3R1(4), PLA2G4A(21), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8) 34558555 285 198 267 67 33 110 65 23 54 0 0.0285 1.000 1.000 237 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 39312877 333 197 329 91 48 135 63 30 57 0 0.0416 1.000 1.000 238 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9) 39312877 333 197 329 91 48 135 63 30 57 0 0.0416 1.000 1.000 239 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(9), ATF2(10), CALM1(3), CALM2(1), EGFR(86), ELK1(3), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PAK1(9), PRKCA(10), PTK2(6), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6) 26949018 255 193 200 50 27 78 32 46 72 0 0.0167 1.000 1.000 240 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EARS2(5), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GFPT2(10), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), GMPS(9), GNPNAT1(1), GOT1(3), GOT2(6), GPT2(5), GSR(5), GSS(4), NADSYN1(2), NAGK(6), PPAT(1), QARS(6) 31784864 300 193 299 75 27 122 53 35 62 1 0.0507 1.000 1.000 241 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ITPA(1), NT5E(5), NT5M(3), NUDT2(3), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), RRM1(6), RRM2(6), TK1(1), TK2(1), TXNRD1(7), TYMS(3), UCK2(10), UMPS(4), UNG(5), UPB1(2), UPP1(6) 45844839 316 193 314 95 39 126 70 31 48 2 0.394 1.000 1.000 242 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), CARM1(4), COMT(1), DBH(12), DCT(16), DDC(8), ECH1(1), ESCO1(10), ESCO2(4), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NAT6(1), PNMT(1), PNPLA3(4), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TAT(9), TH(7), TPO(33), TYR(29), TYRP1(5), WBSCR22(3) 47774422 339 192 334 110 56 123 57 38 65 0 0.435 1.000 1.000 243 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(7), AKT3(7), BCR(11), BLNK(2), BTK(25), CD19(5), CSK(2), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PI3(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), RAF1(6), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8) 42056644 278 191 260 83 29 102 71 27 49 0 0.390 1.000 1.000 244 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH4A1(6), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), GATM(8), GLUD1(4), GOT1(3), GOT2(6), MAOA(5), MAOB(3), NOS1(29), NOS3(12), OAT(3), ODC1(1), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), P4HB(5), PYCR1(1), RARS(6), SMS(3) 35307606 282 190 280 90 37 101 55 38 50 1 0.391 1.000 1.000 245 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(7), AKR1B10(10), B4GALT1(1), B4GALT2(4), G6PC(7), G6PC2(8), GAA(12), GALK1(3), GALK2(3), GALT(5), GANC(3), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), HSD3B7(7), LCT(50), MGAM(51), PFKL(9), PFKM(7), PFKP(5), PGM1(3), PGM3(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2), UGP2(4) 30815039 275 190 274 82 46 115 57 20 37 0 0.131 1.000 1.000 246 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(9), CALR(2), CANX(5), CD4(8), CD8A(4), CD8B(5), CIITA(5), CREB1(2), CTSB(2), CTSS(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), HSP90AA1(8), HSP90AB1(9), HSPA5(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KIR3DL3(2), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LGMN(4), LTA(3), NFYA(1), NFYB(1), NFYC(6), PDIA3(4), PSME1(2), PSME2(3), RFX5(9), RFXANK(1), TAP1(1), TAP2(8), TAPBP(4) 37467191 272 190 264 86 22 108 59 34 49 0 0.613 1.000 1.000 247 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CAT(3), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADHA(3), KMO(9), KYNU(17), MAOA(5), MAOB(3), SDS(4), TDO2(9), TPH1(8), WARS(6), WARS2(7) 44374676 344 190 340 115 43 127 70 44 60 0 0.628 1.000 1.000 248 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), ELK1(3), FPR1(10), GNA15(1), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PAK1(9), PIK3C2G(19), PLCB1(52), PPP3CA(14), PPP3CB(3), PPP3CC(3), RAF1(6), RELA(3), SYT1(6) 30659672 262 189 252 67 31 113 45 20 53 0 0.0544 1.000 1.000 249 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(4), ALDOB(8), ALDOC(2), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GAPDHS(10), GCK(6), GOT1(3), GOT2(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6B(3), LDHB(4), LDHC(6), MDH1(3), MDH2(3), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PDHX(4), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGK1(4), PGK2(27), PKLR(16), TNFAIP1(1), TPI1(9) 34015838 316 189 315 95 52 131 50 34 49 0 0.115 1.000 1.000 250 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(7), ARRB2(4), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CLCA1(14), CLCA2(29), CLCA4(30), CNGA3(15), CNGA4(15), CNGB1(10), GNAL(5), GUCA1A(7), GUCA1B(4), GUCA1C(7), PDC(1), PDE1C(28), PRKACA(3), PRKACB(9), PRKACG(4), PRKG1(20), PRKG2(15), PRKX(3) 24535411 271 187 270 86 28 118 53 22 50 0 0.440 1.000 1.000 251 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPS(6), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CLC(3), CPT1B(6), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), ETNK1(5), GNPAT(5), GPD1(3), GPD2(9), LCAT(6), LGALS13(5), PAFAH1B1(1), PAFAH2(3), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB2(12), PLCG1(7), PLCG2(18), PPAP2A(2), PPAP2B(3), PPAP2C(1) 39734673 307 186 301 99 45 100 77 26 58 1 0.552 1.000 1.000 252 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(33), AXIN1(7), CCND1(3), CD14(1), CTNNB1(20), DVL1(5), FZD1(6), GJA1(11), GNAI1(10), GSK3B(4), IRAK1(6), LBP(8), LEF1(12), LY96(3), MYD88(1), NFKB1(6), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), TLR4(64), TOLLIP(2), WNT1(6) 24506970 252 185 232 55 24 116 43 22 47 0 0.0125 1.000 1.000 253 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(7), APC(33), ATF2(10), AXIN1(7), BMP10(11), BMP2(1), BMP4(6), BMP5(6), BMP7(12), BMPR1A(4), BMPR2(10), CHRD(13), CTNNB1(20), DVL1(5), FZD1(6), GATA4(7), GSK3B(4), MAP3K7(10), MEF2C(6), MYL2(8), NKX2-5(8), NOG(1), NPPA(3), NPPB(3), RFC1(13), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), WNT1(6) 29159681 266 183 255 66 36 103 49 27 51 0 0.103 1.000 1.000 254 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(23), GABBR1(8), GPRC5A(3), GPRC5B(14), GPRC5C(10), GPRC5D(2), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM7(43), GRM8(52) 16886110 290 183 287 86 49 128 67 17 28 1 0.0406 1.000 1.000 255 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(2), ACOX1(5), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP4A11(8), CYP4A22(1), ECHS1(4), EHHADH(13), GCDH(7), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8) 39393905 254 183 248 66 35 88 49 32 50 0 0.0878 1.000 1.000 256 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(10), EGF(13), EGFR(86), GRB2(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), PTPRB(50), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), SRC(2) 20159948 245 183 191 53 20 67 44 46 68 0 0.142 1.000 1.000 257 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(38), AR(10), ESR1(12), ESR2(6), HNF4A(21), NPM1(5), NR0B1(14), NR1D1(2), NR1D2(1), NR1H2(5), NR1H3(4), NR1I2(4), NR1I3(9), NR2C2(2), NR2E1(9), NR2F1(7), NR2F2(1), NR2F6(1), NR3C1(8), NR4A1(5), NR4A2(18), NR5A1(6), NR5A2(14), PGR(15), PPARA(4), PPARD(6), PPARG(8), RARA(7), RARB(7), RARG(3), ROR1(13), RORA(9), RORC(1), RXRA(1), RXRB(3), RXRG(18), THRA(5), THRB(4), VDR(4) 33642017 310 182 309 108 45 126 66 20 52 1 0.662 1.000 1.000 258 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(7), AKT3(7), ARHGEF11(24), BCL2(5), CDC42(1), DLG4(7), GNA13(6), LPA(47), MAP2K4(8), MAP3K1(7), MAP3K5(14), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PI3(1), PIK3CB(8), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RDX(2), ROCK1(19), ROCK2(9), SERPINA4(16), SRF(1), TBXA2R(1) 39339807 272 182 268 72 25 115 50 32 50 0 0.170 1.000 1.000 259 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), DAG1(3), DGKA(7), GCA(3), ITGA9(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAPK1(2), MAPK3(3), NR1I3(9), PAK1(9), PDE3A(30), PDE3B(16), PI3(1), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PSME1(2), RIPK3(5), RPS4X(2), SGCB(4), VASP(2) 39085275 275 181 261 64 29 98 60 28 59 1 0.0300 1.000 1.000 260 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(14), AADAC(5), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(10), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH7A1(3), ALDH9A1(3), BDH1(4), BDH2(2), DDHD1(11), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADH(2), HADHA(3), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), HSD3B7(7), ILVBL(3), L2HGDH(6), OXCT1(7), OXCT2(2), PDHA1(5), PDHA2(29), PLA1A(6), PPME1(6), PRDX6(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 32639019 282 180 280 88 32 105 64 26 53 2 0.489 1.000 1.000 261 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(3), CALM2(1), DLG4(7), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), NOS1(29), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), SYT1(6) 20405710 240 180 234 75 45 99 46 15 33 2 0.196 1.000 1.000 262 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(20), ACACB(28), ACAT1(2), ACAT2(2), ACOT12(11), ACSS1(5), ACSS2(4), ACYP2(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PCK2(4), PDHA1(5), PDHA2(29), PKLR(16) 37616402 283 179 282 93 43 109 49 30 52 0 0.563 1.000 1.000 263 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(2), CASP2(13), CASP3(5), CASP8(6), CRADD(3), DFFA(3), DFFB(4), FADD(2), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MADD(22), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), RB1(33), RIPK1(11), SPTAN1(21), TNF(2), TRADD(2), TRAF2(5) 30950025 238 179 233 47 19 59 57 26 77 0 0.0295 1.000 1.000 264 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(5), CDK5(3), CDK5R1(3), CHN1(8), LIMK1(3), MAP3K1(7), MYL2(8), MYLK(26), NCF2(8), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLD1(19), PPP1R12B(15), RALBP1(3), RPS6KB1(3), TRIO(37), VAV1(8), WASF1(10) 28260607 250 178 238 64 22 104 57 18 47 2 0.106 1.000 1.000 265 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(3), AKT2(7), AKT3(7), BTK(25), CDKN2A(22), DAPP1(3), GRB2(6), GSK3A(1), GSK3B(4), IARS(9), IGFBP1(6), INPP5D(11), PDK1(6), PIK3CA(30), PPP1R13B(7), PTEN(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SOS1(17), SOS2(13), TEC(12), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2) 28989848 246 178 229 54 23 102 56 19 46 0 0.0340 1.000 1.000 266 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(13), ATP4A(16), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5E(1), ATP5F1(3), ATP5G3(2), ATP5J2(3), ATP5L(3), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6B2(1), COX6C(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(7), LHPP(3), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA12(5), NDUFA13(1), NDUFA4(2), NDUFA5(2), NDUFA6(1), NDUFA7(1), NDUFA8(5), NDUFA9(4), NDUFB1(1), NDUFB10(3), NDUFB11(6), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFB8(1), NDUFB9(2), NDUFC2(3), NDUFS1(10), NDUFS2(4), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(2), NDUFV1(2), NDUFV2(1), NDUFV3(1), PPA1(2), SDHA(8), SDHB(1), SDHD(3), TCIRG1(2), UQCRB(5), UQCRC1(2), UQCRC2(5), UQCRFS1(3), UQCRH(3), UQCRQ(2) 44713921 281 177 278 104 47 92 57 24 59 2 0.863 1.000 1.000 267 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ASL(4), ASS1(5), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), EPRS(27), GATM(8), GLUD1(4), GLUD2(15), GOT1(3), GOT2(6), LAP3(4), NOS1(29), NOS3(12), OAT(3), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), PARS2(1), PRODH(4), PYCR1(1), PYCR2(6), PYCRL(1), RARS(6), RARS2(6) 28625139 264 177 261 73 29 111 51 29 43 1 0.114 1.000 1.000 268 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(5), ALOX12(8), ALOX12B(7), ALOX15(5), ALOX15B(6), ALOX5(10), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP2U1(2), CYP4A11(8), CYP4A22(1), CYP4F2(15), CYP4F3(16), DHRS4(1), EPHX2(3), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), LTA4H(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11) 31159882 266 177 263 76 38 104 60 25 39 0 0.121 1.000 1.000 269 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(9), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(2), CXCR3(3), EGF(13), EGFR(86), HRAS(2), ITGA1(14), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTK2(6), PXN(1), TLN1(15) 26295190 228 177 179 57 20 69 38 44 56 1 0.283 1.000 1.000 270 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GLS(8), GLS2(6), GLUD1(4), GLUL(6), GMPS(9), GOT1(3), GOT2(6), GPT2(5), GSS(4), NADSYN1(2), PPAT(1), QARS(6) 26707796 258 176 257 66 23 103 44 31 56 1 0.115 1.000 1.000 271 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(26), CALM1(3), CALM2(1), CREB1(2), ELK1(3), FOS(3), GNAI1(10), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), JUN(3), MAP2K1(10), MAPK3(3), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RAF1(6), RPS6KA3(6), SYT1(6) 27925393 237 176 228 65 49 99 37 17 33 2 0.0958 1.000 1.000 272 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(7), ELK1(3), FOS(3), IKBKB(9), IRAK1(6), JUN(3), LY96(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), PPARA(4), RELA(3), TLR10(16), TLR2(10), TLR3(4), TLR4(64), TLR6(11), TLR7(17), TLR9(9), TOLLIP(2), TRAF6(6) 29367557 241 176 240 80 15 100 47 26 53 0 0.752 1.000 1.000 273 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(53), BMPR1B(7), CCND2(4), CDK4(3), CDKN1B(5), DAZL(2), DMC1(1), EGR1(6), ESR2(6), FSHR(37), GJA4(6), INHA(1), LHCGR(14), MLH1(8), MSH5(8), NCOR1(23), NR5A1(6), NRIP1(13), PGR(15), PRLR(18), PTGER2(4), SMPD1(3), VDR(4), ZP2(5) 28059230 252 175 247 55 36 92 51 28 43 2 0.0177 1.000 1.000 274 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), AKR1D1(12), ARSB(6), ARSD(6), ARSE(5), CYP11B1(27), CYP11B2(24), HSD11B1(9), HSD17B2(6), HSD17B3(3), HSD3B1(6), HSD3B2(15), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28) 22158661 257 174 254 75 21 117 64 24 30 1 0.196 1.000 1.000 275 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(6), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDK5(3), F2(9), FYN(8), GNA11(4), GNAI1(10), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), JAK2(16), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MAPT(15), MYLK(26), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), SYT1(6) 33357943 256 174 251 77 45 87 46 28 50 0 0.295 1.000 1.000 276 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(7), B4GALT1(1), B4GALT2(4), FBP2(2), G6PC(7), GAA(12), GALK1(3), GALK2(3), GALT(5), GANAB(9), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), LCT(50), MGAM(51), PFKM(7), PFKP(5), PGM1(3), PGM3(3) 26076697 235 174 234 67 37 102 48 16 32 0 0.0743 1.000 1.000 277 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(5), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GCNT1(8), GCNT3(2), GCNT4(9), OGT(19), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(8), WBSCR17(33) 26072743 259 174 255 98 35 99 69 22 34 0 0.966 1.000 1.000 278 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(2), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CFLAR(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAF1(10), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), PTPN13(21), RB1(33), RIPK2(2), SPTAN1(21) 32622253 236 173 231 55 13 60 55 28 80 0 0.312 1.000 1.000 279 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(8), AGXT2(13), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), GNMT(1), HSD3B7(7), MAOA(5), MAOB(3), PEMT(2), PHGDH(7), PIPOX(2), PISD(2), PSAT1(5), PSPH(6), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SARDH(10), SARS(5), SARS2(4), SDS(4), SHMT1(2), SHMT2(2), TARS(14), TARS2(11) 34156007 250 173 249 82 37 91 53 27 41 1 0.383 1.000 1.000 280 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(25), CALM1(3), CALM2(1), CD79A(2), CD79B(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK14(4), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8) 30760682 219 172 211 57 32 85 44 18 40 0 0.0989 1.000 1.000 281 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), XYLB(6) 22159835 244 171 242 65 9 118 59 22 36 0 0.252 1.000 1.000 282 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(9), ACTN1(7), ACTN2(43), BCAR1(3), BCR(11), CAPN1(2), CAPNS1(1), CAPNS2(2), CAV1(1), CRKL(4), CSK(2), FYN(8), GRB2(6), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(2), PPP1R12B(15), PTK2(6), PXN(1), RAF1(6), RAP1A(1), ROCK1(19), SHC1(6), SOS1(17), SRC(2), TLN1(15), VCL(8), ZYX(6) 37582153 244 171 238 85 34 84 53 32 41 0 0.761 1.000 1.000 283 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(26), ARHGEF1(5), F2(9), F2R(10), F2RL3(2), GNA12(1), GNA13(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), MAP3K7(10), PIK3CA(30), PIK3R1(4), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2B(14), ROCK1(19) 20726309 236 171 224 49 27 106 41 19 42 1 0.00266 1.000 1.000 284 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(7), AKT3(7), ANKRD6(2), APC(33), AXIN1(7), AXIN2(5), CER1(7), CSNK1A1(2), CTNNB1(20), DACT1(24), DKK1(3), DKK2(14), DKK4(2), DVL1(5), FSTL1(4), GSK3A(1), GSK3B(4), LRP1(36), MVP(6), NKD1(6), NKD2(8), PIN1(1), PSEN1(6), PTPRA(11), SENP2(6), SFRP1(2), TSHB(5), WIF1(3) 32236645 240 171 230 73 34 105 38 21 42 0 0.373 1.000 1.000 285 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(9), CARS(4), CARS2(3), DARS(3), DARS2(4), EARS2(5), EPRS(27), FARS2(5), FARSA(5), FARSB(5), GARS(3), HARS(5), HARS2(4), IARS(9), IARS2(15), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), MTFMT(1), NARS(4), NARS2(6), PARS2(1), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(4), TARS(14), TARS2(11), VARS(10), VARS2(2), WARS(6), WARS2(7), YARS(3), YARS2(10) 43790134 254 170 251 63 27 95 56 24 52 0 0.0730 1.000 1.000 286 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3) 28197351 222 170 207 56 26 73 46 29 47 1 0.184 1.000 1.000 287 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG5(1), ALG6(1), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), DAD1(2), DDOST(1), DHDDS(2), DOLPP1(1), DPAGT1(5), DPM1(5), FUT8(7), GANAB(9), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), RFT1(4), RPN1(3), RPN2(4), ST6GAL1(4), STT3B(4) 33965732 235 169 235 63 28 96 43 28 40 0 0.159 1.000 1.000 288 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(2), B3GALT1(5), B3GALT2(4), B3GALT4(1), B3GALT5(3), B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALNT1(9), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT6(5), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GBGT1(2), GCNT2(5), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGX(4), PIGZ(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST3GAL5(3), ST3GAL6(6), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12), UGCG(2) 38645581 260 167 258 98 39 93 58 26 44 0 0.828 1.000 1.000 289 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(6), ARSB(6), FUCA1(2), FUCA2(3), GALNS(3), GBA(7), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NAGLU(5), NEU1(2), NEU2(7), NEU3(5), NEU4(13), SPAM1(25) 27360330 219 167 218 78 30 98 35 27 29 0 0.682 1.000 1.000 290 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(4), ACTR3(2), ARHGAP1(5), ARHGAP4(14), ARHGAP5(17), ARHGAP6(17), ARHGEF1(5), ARHGEF11(24), ARHGEF5(4), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), BAIAP2(3), DIAPH1(3), GSN(4), LIMK1(3), MYL2(8), MYLK(26), OPHN1(16), PFN1(1), PIP5K1A(6), PIP5K1B(6), PPP1R12B(15), ROCK1(19), SRC(2), TLN1(15), VCL(8) 36548965 239 167 237 65 34 86 41 26 52 0 0.109 1.000 1.000 291 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(22), CARM1(4), CCND1(3), CREBBP(30), EP300(11), ERCC3(5), ESR1(12), GRIP1(13), GTF2A1(3), GTF2E1(8), GTF2F1(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), MEF2C(6), NCOR2(30), NR0B1(14), NRIP1(13), PELP1(10), POLR2A(11), TBP(1) 36770103 251 166 251 73 38 94 64 14 41 0 0.268 1.000 1.000 292 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(12), ACAA2(2), ACADM(8), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), AOX1(22), AUH(2), BCAT1(3), BCAT2(2), BCKDHA(1), BCKDHB(14), DBT(8), DLD(9), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HADHB(10), HIBADH(2), HIBCH(4), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), OXCT2(2), PCCA(6), PCCB(3) 34662383 240 166 237 66 23 76 66 26 48 1 0.396 1.000 1.000 293 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(13), C5(6), C6(29), C7(39), ICAM1(2), IL1A(4), IL6(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELP(29), SELPLG(2), TNF(2), VCAM1(28) 19976575 234 166 233 68 15 101 59 23 35 1 0.451 1.000 1.000 294 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(10), BAX(3), BCL2(5), BCL2A1(1), BCL2L1(3), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CD40(3), CD40LG(9), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKE(9), LTA(3), MCL1(1), NFKB1(6), NFKBIA(4), NGFR(5), NR3C1(8), NTRK1(14), PTPN13(21), RIPK1(11), TFG(4), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4), TRAF6(6) 34956034 236 164 235 90 15 96 56 27 41 1 0.958 1.000 1.000 295 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(5), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), ELAVL1(5), FLT1(31), FLT4(20), HIF1A(2), HRAS(2), KDR(56), NOS3(12), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PXN(1), SHC1(6), VHL(1) 27087280 218 164 205 57 30 89 40 21 38 0 0.123 1.000 1.000 296 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(4), CDC7(6), CDK2(1), CDT1(1), DIAPH2(18), GMNN(1), MCM10(10), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), NACA(15), PCNA(1), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), PRIM1(3), RFC1(13), RFC2(4), RFC3(3), RFC4(7), RFC5(3), RPA1(2), RPA2(2), RPA3(1), RPA4(8), UBA52(1), UBC(14) 40583197 230 163 230 64 28 79 54 24 44 1 0.436 1.000 1.000 297 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(26), AKT1(3), ASAH1(3), GNAI1(10), GNB1(2), GNGT1(6), ITGAV(14), ITGB3(13), MAPK1(2), MAPK3(3), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCB1(52), PRKCA(10), PTK2(6), SMPD1(3), SRC(2) 22064930 235 163 223 65 22 102 51 20 38 2 0.152 1.000 1.000 298 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(8), AGXT2(13), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), ATP6V0C(4), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CPT1B(6), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), MAOA(5), MAOB(3), PEMT(2), PISD(2), PLCB2(12), PLCG1(7), PLCG2(18), PSPH(6), SARDH(10), SARS(5), SHMT1(2), SHMT2(2), TARS(14) 33546941 236 163 234 81 41 76 53 29 36 1 0.551 1.000 1.000 299 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(9), ABAT(12), ACY3(4), ADSL(2), ADSS(6), ADSSL1(4), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), ASRGL1(3), ASS1(5), CAD(25), DARS(3), DARS2(4), DDO(5), DLAT(10), DLD(9), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), NARS2(6), PC(9), PDHA1(5), PDHA2(29) 30242893 244 162 244 66 35 94 49 23 42 1 0.0995 1.000 1.000 300 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), AMDHD1(4), AOC2(6), AOC3(11), ASPA(5), CARM1(4), CNDP1(10), DDC(8), FTCD(8), HAL(5), HARS(5), HARS2(4), HDC(16), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), PRPS1(3), PRPS2(4), UROC1(14), WBSCR22(3) 31764646 223 162 221 69 44 73 43 24 39 0 0.235 1.000 1.000 301 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(7), AKR1B10(10), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), FUK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), HSD3B7(7), KHK(3), LHPP(3), MPI(4), MTMR1(11), MTMR2(2), MTMR6(9), PFKFB1(10), PFKFB2(2), PFKFB3(7), PFKFB4(6), PFKL(9), PFKM(7), PFKP(5), PGM2(8), PHPT1(1), PMM1(3), PMM2(1), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SORD(2), TPI1(9), TSTA3(1) 29574893 231 160 230 64 46 85 44 18 38 0 0.0514 1.000 1.000 302 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ATP6V0C(4), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADHA(3), PLOD1(5), PLOD2(12), PLOD3(10), SDS(4), SHMT1(2), SHMT2(2), TMLHE(9) 29411929 224 160 221 62 30 87 49 28 29 1 0.157 1.000 1.000 303 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(7), AKT3(7), CISH(1), GRB2(6), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(10), INPP5D(11), JAK1(11), JAK2(16), JAK3(10), NR0B2(3), PI3(1), PIK3CA(30), PPP1R13B(7), RPS6KB1(3), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT6(2), TYK2(5) 29558969 205 160 191 65 23 85 47 23 27 0 0.625 1.000 1.000 304 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(10), CD2(6), CD33(13), CD5(7), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(4), IL4(1), IL5(2), ITGAX(52), TLR2(10), TLR4(64), TLR7(17), TLR9(9) 15018623 220 159 219 65 19 111 35 21 32 2 0.0772 1.000 1.000 305 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(20), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(2), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PKLR(16) 29693112 242 158 241 64 34 93 45 28 42 0 0.0983 1.000 1.000 306 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(5), ALOX12(8), ALOX15(5), ALOX5(10), CYP4F2(15), CYP4F3(16), EPX(14), GGT1(1), LPO(7), LTA4H(3), MPO(15), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11), TPO(33) 22337017 240 157 236 76 38 81 61 25 35 0 0.344 1.000 1.000 307 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(10), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2F1(4), GTF2H1(4), GTF2H3(1), GTF2H4(1), GTF2I(7), GTF2IRD1(10), STON1(11), TAF1(22), TAF1L(65), TAF2(13), TAF4(13), TAF4B(6), TAF5(5), TAF5L(9), TAF6(3), TAF6L(3), TAF7(3), TAF7L(6), TAF9(3), TAF9B(5), TBPL1(1), TBPL2(4) 29022582 224 156 224 51 28 81 49 21 43 2 0.0807 1.000 1.000 308 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(10), CDC42(1), CREB1(2), DAXX(8), DDIT3(2), ELK1(3), GRB2(6), HMGN1(1), HRAS(2), HSPB1(1), HSPB2(1), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MYC(4), PLA2G4A(21), RIPK1(11), RPS6KA5(10), SHC1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5) 29475986 221 156 220 49 21 88 46 22 44 0 0.0357 1.000 1.000 309 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(21), EEF1A2(8), EEF1B2(7), EEF1D(2), EEF1G(2), EEF2(7), EEF2K(7), EIF1AX(3), EIF2AK1(12), EIF2AK2(5), EIF2AK3(12), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4EBP2(1), EIF4G1(19), EIF4G3(20), EIF5(1), EIF5A(2), EIF5B(14), GSPT2(8), PABPC1(5), PABPC3(15), PAIP1(6), SLC35A4(1) 34830836 209 155 208 54 16 79 55 25 34 0 0.246 1.000 1.000 310 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1B10(10), AKR1C4(4), AKR1D1(12), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), HSD3B7(7), LIPA(2), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SLC27A5(7), SOAT1(8), SOAT2(2), SRD5A1(4) 25394461 206 153 203 63 19 81 48 22 36 0 0.368 1.000 1.000 311 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(6), ARSE(5), ASAH1(3), B4GALT6(5), CERK(4), DEGS1(2), DEGS2(1), ENPP7(11), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SGMS1(4), SGMS2(3), SGPP1(3), SGPP2(2), SMPD1(3), SMPD3(6), SMPD4(13), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(2), UGT8(8) 28419660 211 152 209 67 37 99 42 11 22 0 0.198 1.000 1.000 312 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), COMT(1), DBH(12), DCT(16), DDC(8), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), MAOA(5), MAOB(3), PNMT(1), TAT(9), TH(7), TPO(33), TYR(29) 25458965 246 152 243 80 38 97 35 28 48 0 0.292 1.000 1.000 313 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(17), DIAPH1(3), FYN(8), GSN(4), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PFN1(1), PIK3CA(30), PIK3R1(4), PTK2(6), PXN(1), RAF1(6), ROCK1(19), SHC1(6), SRC(2), TLN1(15) 30127071 193 151 180 54 22 75 36 26 34 0 0.334 1.000 1.000 314 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(9), AGT(4), AGTR1(9), AGTR2(6), CMA1(8), COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), REN(6) 20378769 234 149 233 81 20 133 35 13 32 1 0.955 1.000 1.000 315 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(26), AKT1(3), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), GNAS(29), GRB2(6), HRAS(2), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(30), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RPS6KA1(6), RPS6KA5(10), SOS1(17) 23289810 204 149 188 58 36 83 39 21 23 2 0.361 1.000 1.000 316 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(7), GHR(19), GRB2(6), HRAS(2), INSR(10), IRS1(20), JAK2(16), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTPN6(6), RAF1(6), RPS6KA1(6), SHC1(6), SLC2A4(4), SOS1(17), SRF(1), STAT5A(3), STAT5B(8) 26607771 203 149 188 53 29 77 45 25 27 0 0.110 1.000 1.000 317 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(12), ACACA(20), ACACB(28), ACADM(8), ACAT1(2), ACAT2(2), ACSS1(5), ACSS2(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), HIBCH(4), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 31991829 204 149 203 69 26 74 43 17 44 0 0.819 1.000 1.000 318 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(5), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MPL(5), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), THPO(7) 24178108 180 149 165 48 19 62 35 26 38 0 0.353 1.000 1.000 319 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(10), ADCY3(7), ADCY9(12), ARF1(1), ARF3(1), ARF5(2), ARF6(1), ARL4D(4), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(5), GNAS(29), PDIA4(8), PLCG1(7), PLCG2(18), PRKCA(10), SEC61A1(5), SEC61A2(6), SEC61G(3), TRIM23(4) 29658651 204 148 198 65 34 79 40 16 34 1 0.397 1.000 1.000 320 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(10), BCR(11), BLNK(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8IP3(7), PAPPA(32), RPS6KA1(6), RPS6KA3(6), SHC1(6), SOS1(17), SYK(5), VAV1(8), VAV2(8), VAV3(32) 25525164 195 148 191 51 25 71 39 24 35 1 0.120 1.000 1.000 321 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(11), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPHN(5), NSF(4), SRC(2), UBQLN1(6) 9626774 188 146 185 62 23 91 33 19 22 0 0.612 1.000 1.000 322 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(19), POLA2(7), POLB(4), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLG(12), POLG2(3), POLH(1), POLI(3), POLK(3), POLL(7), POLM(6), POLQ(36), PRIM1(3), PRIM2(14), REV1(10), REV3L(20), RFC5(3) 32635969 198 146 197 49 22 80 47 23 25 1 0.204 1.000 1.000 323 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(10), F2RL3(2), GNAI1(10), GNB1(2), GNGT1(6), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), PLA2G4A(21), PLCB1(52), PRKCA(10), PTGS1(18), PTK2(6), RAF1(6), SRC(2), SYK(5), TBXAS1(11) 19547606 207 146 202 46 21 94 41 20 31 0 0.0126 1.000 1.000 324 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(7), AKT3(7), BCL2(5), GRB2(6), GSK3A(1), GSK3B(4), IL4R(10), IRS1(20), JAK1(11), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PPP1R13B(7), RAF1(6), SHC1(6), SOS1(17), SOS2(13), STAT6(2) 28596494 196 145 181 64 24 79 45 20 28 0 0.649 1.000 1.000 325 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(44), CREB1(2), CREB5(18), DUSP4(2), DUSP6(4), DUSP9(6), EEF2K(7), EIF4E(4), GRB2(6), MAP2K1(10), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MOS(9), NFKB1(6), RAP1A(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), SHC1(6), SOS1(17), SOS2(13), TRAF3(4) 23617530 196 145 170 42 22 78 47 15 33 1 0.0184 1.000 1.000 326 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9) 18346764 198 144 191 55 40 70 37 12 37 2 0.243 1.000 1.000 327 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(4), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), LIMK1(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), NOX1(8), PIK3C2G(19), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2(6), RAF1(6), ROCK2(9) 20171859 201 144 194 43 32 84 39 18 28 0 0.0272 1.000 1.000 328 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9) 18346764 198 144 191 55 40 70 37 12 37 2 0.243 1.000 1.000 329 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(8), ASRGL1(3), CA1(6), CA12(2), CA13(1), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), HAL(5) 17120398 183 144 182 58 17 80 31 23 32 0 0.590 1.000 1.000 330 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), BTRC(12), CDC16(2), CDC20(8), CDC23(3), CDC27(7), CUL1(14), CUL2(8), CUL3(13), FBXW11(2), FBXW7(15), FZR1(3), ITCH(8), SKP1(4), SKP2(3), SMURF1(8), SMURF2(4), TCEB1(2), UBA1(4), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(4), UBE2E3(6), VHL(1), WWP1(13), WWP2(7) 32170628 198 144 197 46 27 61 41 31 38 0 0.0754 1.000 1.000 331 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(3), AKT2(7), AKT3(7), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PIK3CB(8), PITX2(8), PLD1(19), PLD2(7), PLD3(4), VN1R1(2) 35811416 208 144 207 59 23 79 43 19 43 1 0.281 1.000 1.000 332 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(16), CAMK2D(7), DAG1(3), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFAT5(13), PDE6A(17), PDE6B(15), PDE6C(12), PDE6G(3), SLC6A13(12), TF(13) 28645135 204 144 203 62 28 73 49 20 33 1 0.384 1.000 1.000 333 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), AOX1(22), BCAT1(3), BCKDHA(1), BCKDHB(14), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), HIBADH(2), HMGCL(1), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), PCCA(6), PCCB(3), SDS(4) 28978649 194 143 192 56 16 66 47 25 40 0 0.541 1.000 1.000 334 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BCL2(5), BCL2L1(3), CBL(10), CFLAR(2), CRKL(4), E2F1(3), FOS(3), GRB2(6), HRAS(2), IL2RA(6), IL2RB(7), IL2RG(5), IRS1(20), JAK1(11), JAK3(10), MAPK1(2), MAPK3(3), MYC(4), NMI(2), PIK3CA(30), PIK3R1(4), PTPN6(6), RAF1(6), RPS6KB1(3), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5) 28960398 199 142 184 61 28 72 51 23 25 0 0.466 1.000 1.000 335 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(12), ACADL(4), ACADM(8), ACADSB(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), MLYCD(2), SDS(4), SMS(3), UPB1(2) 23401329 213 141 211 52 26 84 39 22 41 1 0.0375 1.000 1.000 336 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(33), AXIN1(7), CREBBP(30), CTNNB1(20), DVL1(5), EP300(11), FZD1(6), GSK3B(4), HDAC1(4), LDB1(3), LEF1(12), PITX2(8), TRRAP(51), WNT1(6) 26615618 200 140 191 40 40 65 41 17 37 0 0.00489 1.000 1.000 337 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), P4HB(5), SLC23A1(3), SLC23A2(8), SLC2A1(1), SLC2A3(10) 20161255 219 140 218 71 23 119 34 10 32 1 0.753 1.000 1.000 338 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20), MASP1(13), MASP2(8), MBL2(13) 17155255 195 139 193 60 19 90 33 20 32 1 0.478 1.000 1.000 339 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(13), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(29), ATP7B(22), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6C(1), COX8A(1), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1), SDHA(8), SDHB(1), SHMT1(2), UQCRB(5), UQCRC1(2), UQCRFS1(3), UQCRH(3) 30733115 208 139 205 78 34 79 30 22 41 2 0.800 1.000 1.000 340 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(14), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HMGCL(1), L2HGDH(6), OXCT1(7), PDHA1(5), PDHA2(29), SDHB(1), SDS(4) 20733189 189 138 188 58 22 70 40 20 36 1 0.460 1.000 1.000 341 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(10), CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), HDAC5(5), IGF1(4), IGF1R(8), INSR(10), MAP2K6(5), MAPK14(4), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), NFATC1(9), NFATC2(15), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), SYT1(6), YWHAH(1) 27758602 169 138 155 51 20 72 27 15 35 0 0.247 1.000 1.000 342 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(5), ACO2(3), CLYBL(5), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), OGDHL(35), PC(9), PCK1(21), PCK2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 24111107 171 138 170 65 28 61 24 25 33 0 0.761 1.000 1.000 343 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(9), EPHA4(18), EPHB1(44), FYN(8), ITGA1(14), ITGB1(6), L1CAM(42), LYN(6), RAP1B(2), SELP(29) 12772799 178 137 177 47 28 68 33 22 25 2 0.131 1.000 1.000 344 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(5), CREBBP(30), EP300(11), FYN(8), IL2RG(5), IL7(2), IL7R(21), JAK1(11), JAK3(10), LCK(9), NMI(2), PIK3CA(30), PIK3R1(4), PTK2B(14), STAT5A(3), STAT5B(8) 22465484 173 137 163 49 22 63 37 19 32 0 0.319 1.000 1.000 345 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(12), ACACA(20), ACADL(4), ACADM(8), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), LDHA(10), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SDS(4), SUCLA2(5), SUCLG1(5), SUCLG2(1) 26690520 182 137 181 50 19 62 40 19 42 0 0.418 1.000 1.000 346 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(18), DUSP1(1), DUSP10(11), EEF2K(7), EIF4E(4), ELK1(3), GADD45A(2), HSPB1(1), IL1R1(2), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K10(4), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MKNK1(4), MKNK2(2), MYEF2(12), NFKB1(6), NR2C2(2), SRF(1), TRAF6(6) 26680683 180 137 178 47 16 76 36 13 39 0 0.177 1.000 1.000 347 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), GHR(19), IRS1(20), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(4), PABPC1(5), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PRKCA(10), PTEN(11), RPS6KB1(3) 22744566 181 136 169 50 16 79 43 16 27 0 0.400 1.000 1.000 348 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(5), BCR(11), CRKL(4), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), MYC(4), PIK3CA(30), PIK3R1(4), RAF1(6), SOS1(17), STAT1(7), STAT5A(3), STAT5B(8) 22565531 162 136 146 36 15 57 42 21 27 0 0.0626 1.000 1.000 349 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA2(2), ANXA3(6), ANXA4(5), ANXA5(6), ANXA6(8), CYP11A1(5), EDN1(1), EDNRA(3), EDNRB(16), HPGD(5), HSD11B1(9), PLA2G4A(21), PRL(3), PTGDR(8), PTGDS(4), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), PTGIS(12), PTGS1(18), PTGS2(12), S100A6(1), SCGB1A1(2), TBXAS1(11) 16642391 188 135 186 48 25 67 44 17 33 2 0.0756 1.000 1.000 350 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C8B(20), C9(20), MASP1(13) 16788403 194 134 192 56 18 89 33 23 30 1 0.313 1.000 1.000 351 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), AGMAT(2), ALDH18A1(3), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), ASS1(5), CPS1(71), GATM(8), MAOA(5), MAOB(3), NAGS(1), ODC1(1), OTC(10), SAT1(3), SMS(3), SRM(2) 23626242 180 133 179 60 22 68 35 25 29 1 0.593 1.000 1.000 352 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(12), ACADM(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HIBCH(4), MLYCD(2), SMS(3), SRM(2), UPB1(2) 21711201 196 133 194 48 26 78 39 17 35 1 0.0425 1.000 1.000 353 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(8), CA1(6), CA12(2), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUL(6), HAL(5) 15322390 164 133 163 49 17 67 27 22 31 0 0.468 1.000 1.000 354 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(2), AZIN1(4), BTG1(3), CBX3(4), CLOCK(4), CRY1(7), CRY2(6), DAZAP2(1), DNAJA1(3), EIF4G2(5), ETV6(5), GFRA1(20), GSTM3(2), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(11), NCKAP1(11), NCOA4(6), NR1D2(1), PER1(10), PER2(11), PPP1R3C(3), PPP2CB(3), PSMA4(2), PURA(2), SF3A3(2), SUMO3(5), TOB1(4), TUBB3(3), UGP2(4), VAPA(2), ZFR(10) 29207628 172 132 171 45 20 60 39 16 36 1 0.315 1.000 1.000 355 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), PRKCE(5), SOD1(1) 6364786 166 132 163 55 16 85 30 16 18 1 0.611 1.000 1.000 356 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), PON1(3) 23543387 188 132 188 72 25 72 38 23 30 0 0.818 1.000 1.000 357 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(33), AXIN1(7), BTRC(12), CCND1(3), CREBBP(30), CSNK1A1(2), CSNK1D(7), CSNK2A1(5), CTBP1(2), CTNNB1(20), DVL1(5), FZD1(6), GSK3B(4), HDAC1(4), MAP3K7(10), MYC(4), NLK(3), PPARD(6), PPP2CA(1), TLE1(5), WIF1(3), WNT1(6) 23421841 178 131 169 33 28 68 33 16 33 0 0.00510 1.000 1.000 358 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), SELE(17), SELL(9), SELP(29) 12885072 166 130 164 51 11 81 39 12 23 0 0.547 1.000 1.000 359 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(3), BLVRB(2), CP(11), CPOX(4), EPRS(27), FECH(4), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UROS(2) 22183495 181 130 180 51 9 88 47 12 25 0 0.356 1.000 1.000 360 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(43), BCAR1(3), CSK(2), CTNNA1(9), CTNNA2(65), CTNNB1(20), PTK2(6), PXN(1), SRC(2), VCL(8) 15247578 166 128 158 51 19 71 34 19 23 0 0.311 1.000 1.000 361 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), GLCE(4), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), NDST1(6), NDST2(6), NDST3(16), NDST4(36) 16652374 172 128 170 49 31 58 41 23 17 2 0.217 1.000 1.000 362 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(17), ARHGEF1(5), GNA12(1), GNA13(6), GNAQ(5), GNB1(2), GNGT1(6), MYL2(8), MYLK(26), PLCB1(52), PPP1R12B(15), PRKCA(10), ROCK1(19) 16694901 172 128 171 40 18 73 28 20 33 0 0.0587 1.000 1.000 363 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(5), CHIT1(11), CMAS(10), CYB5R1(1), GFPT1(8), GFPT2(10), GNE(2), GNPDA1(2), GNPDA2(2), GNPNAT1(1), HEXA(6), HK1(12), HK2(11), HK3(22), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NAGK(6), NANS(2), NPL(4), PGM3(3), PHPT1(1), RENBP(7), UAP1(7) 23026251 161 127 160 42 29 63 26 19 24 0 0.100 1.000 1.000 364 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(3), CALM2(1), CRKL(4), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), PAK1(9), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6) 22790036 154 127 147 48 24 53 30 12 35 0 0.575 1.000 1.000 365 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME3(8), PGK1(4), PGK2(27), PKLR(16), RPE(3), RPIA(8), TKT(3), TKTL1(14), TKTL2(26), TPI1(9) 16185365 159 126 159 34 18 62 33 18 28 0 0.00969 1.000 1.000 366 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IGF1(4), IGF1R(8), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1) 20012310 153 126 138 39 17 58 31 18 29 0 0.218 1.000 1.000 367 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(2), EIF4A2(7), EIF4B(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), MKNK1(4), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3), TSC1(10), TSC2(13) 22071035 152 126 140 39 12 57 40 14 29 0 0.298 1.000 1.000 368 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), FADD(2), IKBKB(9), IL1A(4), IL1R1(2), IRAK1(6), MAP3K1(7), MAP3K7(10), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TLR4(64), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF6(6) 19518685 154 126 153 48 5 65 34 19 31 0 0.602 1.000 1.000 369 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(2), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK5(5), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), SYT1(6), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6) 26390548 149 125 139 51 19 53 29 16 32 0 0.625 1.000 1.000 370 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), INSR(10), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SLC2A4(4), SOS1(17), SRF(1) 20534203 155 124 140 44 19 54 34 21 27 0 0.385 1.000 1.000 371 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(25), DLG4(7), EPHB2(10), F2(9), F2RL1(2), F2RL2(12), F2RL3(2), JUN(3), MAP2K5(4), MAPK1(2), MAPK7(7), MAPK8(2), MYEF2(12), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RAF1(6), RASAL1(10), SRC(2), TEC(12), VAV1(8) 21952267 171 124 169 38 21 70 41 8 31 0 0.0142 1.000 1.000 372 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(7), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), GCK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), KHK(3), MPI(4), PFKFB1(10), PFKFB3(7), PFKFB4(6), PFKM(7), PFKP(5), PMM1(3), PMM2(1), SORD(2), TPI1(9) 19170829 158 122 158 38 33 55 30 13 27 0 0.0156 1.000 1.000 373 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(3), DAB1(34), FYN(8), LRP8(6), RELN(104), VLDLR(5) 11327920 163 122 162 50 17 62 41 14 29 0 0.623 1.000 1.000 374 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(1), CXCL12(3), CXCR4(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(19), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PTK2B(14), PXN(1), RAF1(6), RELA(3) 22098127 159 121 146 40 18 71 31 14 25 0 0.103 1.000 1.000 375 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(9), F2R(10), F3(3), F5(40), F7(10), FGA(20), FGB(18), FGG(4), PROC(4), PROS1(30), SERPINC1(5), TFPI(4) 13160754 162 121 160 41 13 81 26 11 31 0 0.197 1.000 1.000 376 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(29), F2(9), F2R(10), FGA(20), FGB(18), FGG(4), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14) 10835018 168 121 163 47 14 86 33 9 26 0 0.331 1.000 1.000 377 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(5), ATG5(3), ATG7(6), BECN1(1), GABARAPL1(1), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNG(7), PIK3C3(14), PIK3R4(22), PRKAA1(6), PRKAA2(8), ULK1(8), ULK2(9), ULK3(2) 16775574 155 121 153 36 11 76 33 15 19 1 0.124 1.000 1.000 378 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(2), DLAT(10), DLD(9), DLST(5), FH(13), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), PC(9), PDHA1(5), PDHA2(29), PDHX(4), PDK1(6), PDK2(3), PDK3(5), PDK4(2), PDP2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1) 22875222 160 121 159 51 23 63 23 22 29 0 0.499 1.000 1.000 379 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20) 14117892 161 120 160 49 16 70 30 19 25 1 0.510 1.000 1.000 380 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), ESCO1(10), ESCO2(4), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), NAT6(1), PNPLA3(4), PRDX6(5), TAT(9), TPO(33) 27575749 161 120 160 67 31 53 31 20 26 0 0.947 1.000 1.000 381 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(26), AKT1(3), BAX(3), BCL2(5), BCL2L1(3), CSF2RB(14), IGF1(4), IGF1R(8), IL3(4), IL3RA(8), KIT(12), KITLG(6), PIK3CA(30), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), YWHAH(1) 17624187 155 119 144 53 14 70 37 12 20 2 0.631 1.000 1.000 382 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(14), ABCC2(11), ABCG2(14), BCHE(35), CES1(8), CYP3A4(4), CYP3A5(5), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7) 18509913 153 119 152 56 12 69 36 16 20 0 0.788 1.000 1.000 383 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(6), ARSD(6), ARSE(5), ASAH1(3), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SMPD1(3), SPTLC1(3), SPTLC2(3), UGCG(2) 19347418 151 118 150 44 24 74 28 8 17 0 0.156 1.000 1.000 384 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), NAGLU(5), SPAM1(25) 16293964 144 118 143 48 17 67 20 22 18 0 0.524 1.000 1.000 385 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AGPS(6), CHPT1(3), ENPP2(19), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PPAP2A(2), PPAP2B(3), PPAP2C(1) 18600534 156 118 155 38 17 65 29 11 34 0 0.0545 1.000 1.000 386 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1C4(4), AKR1D1(12), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), SOAT2(2), SRD5A1(4) 18668477 161 117 158 45 12 66 37 19 27 0 0.233 1.000 1.000 387 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(12), ADSL(2), ADSS(6), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), CAD(25), DARS(3), DDO(5), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), PC(9) 20822772 156 116 156 48 22 56 27 18 32 1 0.352 1.000 1.000 388 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(9), ADCY1(26), CCNB1(2), CDC25C(8), GNAI1(10), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), MAPK1(2), MAPK3(3), MYT1(24), PIN1(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RPS6KA1(6), SRC(2) 16355330 156 114 153 50 33 60 27 10 24 2 0.397 1.000 1.000 389 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(7), CREBBP(30), DUSP1(1), EP300(11), IKBKB(9), IL1B(1), MAP2K3(13), MAP2K6(5), MAP3K7(10), MAPK14(4), MYD88(1), NFKB1(6), NFKBIA(4), NR3C1(8), RELA(3), TGFBR1(7), TGFBR2(7), TLR2(10), TNF(2) 23832807 139 114 138 43 12 48 29 12 38 0 0.643 1.000 1.000 390 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TAT(9), TPO(33) 17678811 149 114 148 62 30 49 28 20 22 0 0.855 1.000 1.000 391 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(33), ASAH1(3), CAMP(4), CASP3(5), CERK(4), CREB1(2), CREB5(18), CXCL2(1), DAG1(3), EPHB2(10), FOS(3), GNAQ(5), ITPKA(2), ITPKB(7), JUN(3), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8) 22589372 149 114 148 33 21 49 30 9 40 0 0.0495 1.000 1.000 392 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(10), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), GAS2(10), LMNA(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), SPTAN1(21), TNFRSF10B(3), TNFRSF25(2), TNFSF10(3), TNFSF12(1), TRADD(2), TRAF2(5) 26779656 146 113 146 53 8 51 38 16 33 0 0.935 1.000 1.000 393 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(12), BAIAP2(3), CASP1(8), CASP3(5), CASP7(3), CASP8(6), GAPDH(5), INSR(10), ITCH(8), MAGI1(21), MAGI2(33), RERE(12), WWP1(13), WWP2(7) 19234129 146 113 145 42 16 63 21 14 32 0 0.436 1.000 1.000 394 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(9), ACTN1(7), ACTN2(43), CAPN1(2), CAPNS1(1), CAPNS2(2), ITGA1(14), ITGB1(6), ITGB3(13), PTK2(6), PXN(1), SPTAN1(21), SRC(2), TLN1(15) 22874847 142 113 141 56 15 52 38 19 18 0 0.906 1.000 1.000 395 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(3), CALM2(1), CHUK(7), EGR2(4), EGR3(1), GNAQ(5), MAP3K1(7), MYC(4), NFATC1(9), NFATC2(15), NFKB1(6), NFKBIA(4), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(6), VIP(6), VIPR2(3) 22435877 135 113 132 41 19 54 21 14 26 1 0.394 1.000 1.000 396 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(15), ACE2(9), AGT(4), AGTR1(9), AGTR2(6), ANPEP(10), CMA1(8), CPA3(16), CTSA(4), CTSG(12), ENPEP(18), LNPEP(5), MAS1(5), MME(20), NLN(7), REN(6), THOP1(8) 16967000 162 112 161 62 21 71 28 18 23 1 0.765 1.000 1.000 397 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(2), IFNB1(7), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL1RN(3), IL6(2), IRAK1(6), IRAK2(6), IRAK3(6), JUN(3), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), TGFB1(3), TGFB2(10), TNF(2), TOLLIP(2), TRAF6(6) 23848641 140 112 139 51 6 50 30 17 37 0 0.928 1.000 1.000 398 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL6(2), IL6R(8), IL6ST(3), JAK1(11), JAK2(16), JAK3(10), JUN(3), MAP2K1(10), MAPK3(3), PTPN11(9), RAF1(6), SHC1(6), SOS1(17), SRF(1), STAT3(11) 18997736 135 112 130 35 16 37 32 24 26 0 0.271 1.000 1.000 399 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(33), CDH1(6), CREBBP(30), EP300(11), MAP2K1(10), MAP3K7(10), MAPK3(3), SKIL(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7) 20740652 141 112 138 25 14 50 28 14 35 0 0.0268 1.000 1.000 400 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(34), CR2(20), FCGR2B(7), HLA-DRA(3), HLA-DRB1(5), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41) 12281228 149 111 144 48 11 63 28 10 37 0 0.776 1.000 1.000 401 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(4), ALDOB(8), ALDOC(2), DERA(4), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKL(9), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TALDO1(1), TKT(3), TKTL1(14), TKTL2(26) 19391436 135 111 135 36 16 44 31 17 27 0 0.149 1.000 1.000 402 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13) 16216807 127 111 126 43 21 60 22 9 15 0 0.461 1.000 1.000 403 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(10), ALOX15(5), ALOX5(10), CYP1A2(3), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), HSD3B7(7), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 19242354 152 111 151 62 17 66 37 15 17 0 0.905 1.000 1.000 404 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(9), GLB1(3), HEXA(6), LCT(50), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(3), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12) 13265083 131 111 130 49 24 47 27 12 21 0 0.684 1.000 1.000 405 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(4), DARS(3), EPRS(27), FARS2(5), GARS(3), HARS(5), IARS(9), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), NARS(4), QARS(6), RARS(6), SARS(5), TARS(14), WARS(6), WARS2(7), YARS(3) 25898121 153 110 153 38 12 59 35 18 29 0 0.232 1.000 1.000 406 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(9), HLA-A(8), ITGB1(6), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LAT(4), MAP2K1(10), MAPK3(3), PAK1(9), PIK3CA(30), PIK3R1(4), PTK2B(14), PTPN6(6), SYK(5), VAV1(8) 14993870 132 109 117 29 21 48 18 16 29 0 0.0483 1.000 1.000 407 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2H1(4), GTF2H4(1), ILK(1), MNAT1(2), POLR1A(13), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3B(20), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(2), TAF5(5), TAF6(3), TAF7(3), TAF9(3), TBP(1) 28239498 137 108 137 47 22 40 39 14 21 1 0.865 1.000 1.000 408 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(5), GLI2(28), GLI3(39), GSK3B(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SHH(2), SMO(17), SUFU(2) 13336116 129 108 127 38 34 45 25 7 17 1 0.222 1.000 1.000 409 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(4), CHAT(22), COMT(1), DBH(12), DDC(8), GAD1(7), GAD2(27), HDC(16), MAOA(5), PAH(11), PNMT(1), SLC18A3(19), TH(7), TPH1(8) 11438375 149 106 148 53 23 60 25 10 31 0 0.592 1.000 1.000 410 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL2(7), IL2RA(6), IL2RB(7), IL2RG(5), JAK1(11), JAK3(10), JUN(3), LCK(9), MAP2K1(10), MAPK3(3), MAPK8(2), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5) 18686649 137 106 132 38 16 46 29 20 26 0 0.283 1.000 1.000 411 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), KLK2(10), MAP2K1(10), MAPK3(3), MAPK8(2), NGFR(5), PIK3CA(30), PIK3R1(4), PLCG1(7), RAF1(6), SHC1(6), SOS1(17) 15412157 122 106 107 27 12 50 29 14 17 0 0.0924 1.000 1.000 412 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(6), GALNT10(6), GALNT2(11), GALNT3(12), GALNT4(4), GALNT6(5), GALNT7(9), GALNT8(19), GCNT1(8), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(33) 11655898 125 106 124 62 15 50 31 15 14 0 0.998 1.000 1.000 413 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(8), APC(33), AXIN1(7), BTRC(12), CTNNB1(20), DLL1(5), DVL1(5), FZD1(6), GSK3B(4), NOTCH1(26), PSEN1(6), WNT1(6) 16636417 138 106 130 26 28 48 23 13 26 0 0.00891 1.000 1.000 414 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(3), CALM2(1), CDKN1A(2), GNAQ(5), MARCKS(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), SP1(6), SP3(6), SYT1(6) 16789317 118 105 115 38 19 50 19 8 22 0 0.462 1.000 1.000 415 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(22), BST1(3), CD38(4), ENPP1(14), ENPP3(19), NADK(3), NADSYN1(2), NMNAT1(3), NMNAT2(8), NMNAT3(1), NNMT(7), NNT(11), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT12(7), QPRT(2) 17307368 140 105 138 41 15 50 21 21 33 0 0.457 1.000 1.000 416 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(2), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CD28(4), CD4(8), CXCR3(3), CXCR4(6), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL4(1), IL4R(10), IL5(2), TGFB1(3), TGFB2(10) 16147480 131 105 131 33 14 53 21 13 29 1 0.0856 1.000 1.000 417 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(17), APOA1(3), APOA4(12), APOC1(2), APOC2(2), APOC3(2), APOE(1), CETP(8), CYP7A1(8), DGAT1(1), HMGCR(5), LCAT(6), LDLR(9), LIPC(9), LPL(8), LRP1(36), SCARB1(4), SOAT1(8) 21987629 141 105 137 53 21 50 25 19 25 1 0.832 1.000 1.000 418 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20) 10140162 125 103 124 37 12 55 26 11 20 1 0.578 1.000 1.000 419 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28) 14237894 131 103 130 40 6 59 35 13 18 0 0.514 1.000 1.000 420 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(7), AKT3(7), BPNT1(7), GRB2(6), ILK(1), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PTEN(11), PTK2B(14), RBL2(5), SHC1(6), SOS1(17) 16368664 129 103 116 35 13 57 32 12 15 0 0.347 1.000 1.000 421 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(18), DDX20(4), E2F1(3), E2F4(5), ETS1(8), ETS2(6), ETV3(2), FOS(3), HDAC2(8), HDAC5(5), HRAS(2), JUN(3), NCOR2(30), RBL1(7), RBL2(5), SIN3A(12), SIN3B(2) 20506999 124 102 124 43 15 35 33 17 24 0 0.770 1.000 1.000 422 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(11), ASPA(5), CNDP1(10), DDC(8), HAL(5), HARS(5), HDC(16), MAOA(5), MAOB(3), PRPS1(3), PRPS2(4) 19703306 136 102 136 40 25 46 24 18 23 0 0.194 1.000 1.000 423 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(24), AP2A1(4), AP2M1(5), BIN1(4), CALM1(3), CALM2(1), DNM1(11), EPN1(11), EPS15(7), PICALM(6), PPP3CA(14), PPP3CB(3), PPP3CC(3), SYNJ1(14), SYNJ2(9), SYT1(6) 17322327 125 102 121 39 15 46 25 11 28 0 0.694 1.000 1.000 424 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(8), GTF2F1(4), HDAC3(3), NCOA1(18), NCOA2(22), NCOA3(14), NCOR2(30), POLR2A(11), RARA(7), RXRA(1), TBP(1) 19823020 128 102 128 39 17 43 33 19 16 0 0.510 1.000 1.000 425 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(2), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), ILVBL(3), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCDC(2), PPCS(1), UPB1(2), VNN1(10) 13820415 127 101 124 34 14 59 18 15 20 1 0.220 1.000 1.000 426 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13) 13180834 115 101 114 36 18 57 20 7 13 0 0.333 1.000 1.000 427 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), GATM(8), GLUD1(4), NAGS(1), OAT(3), ODC1(1), OTC(10), PYCR1(1), SMS(3) 13907447 122 101 121 44 12 47 22 18 22 1 0.811 1.000 1.000 428 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(4), CBS(1), CTH(2), GGT1(1), LCMT1(5), LCMT2(7), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(5), PAPSS2(10), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SCLY(4), SEPHS1(4), SEPHS2(2), WBSCR22(3) 20010499 124 100 122 50 22 40 27 13 22 0 0.884 1.000 1.000 429 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), GRB2(6), HRAS(2), IGF1R(8), IRS1(20), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), RAF1(6), SHC1(6), SOS1(17), YWHAH(1) 15299323 118 100 102 28 13 51 26 13 15 0 0.130 1.000 1.000 430 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(7), AKT3(7), CDKN1A(2), ELK1(3), GRB2(6), HRAS(2), MAP2K1(10), MAP2K2(1), NGFR(5), NTRK1(14), PIK3CA(30), PIK3CD(4), SHC1(6), SOS1(17) 12865991 117 100 102 28 11 53 30 12 10 1 0.112 1.000 1.000 431 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(45), ABCB11(28), ABCB4(19), ABCC1(14), ABCC3(13), GSTP1(2) 11611517 121 99 120 35 11 48 27 11 24 0 0.309 1.000 1.000 432 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(3), ANXA1(1), CALM1(3), CALM2(1), GNAS(29), GNB1(2), GNGT1(6), NFKB1(6), NOS3(12), NPPA(3), NR3C1(8), PIK3CA(30), PIK3R1(4), RELA(3), SYT1(6) 14240325 121 98 107 28 17 52 24 8 20 0 0.117 1.000 1.000 433 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), GSR(5), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), OPLAH(10), TXNDC12(2) 17465013 126 98 127 21 15 49 19 10 33 0 0.000431 1.000 1.000 434 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BCL2L1(3), CASP9(6), CDC42(1), CHUK(7), ELK1(3), H2AFX(3), HRAS(2), MAP2K1(10), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RAF1(6), RALA(5), RALBP1(3), RALGDS(5), RELA(3), RHOA(4) 15259168 107 98 93 26 7 47 22 13 18 0 0.163 1.000 1.000 435 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(13), CHUK(7), CRADD(3), IKBKB(9), JUN(3), LTA(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP4K2(4), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNF(2), TRADD(2), TRAF2(5) 19246618 118 98 118 41 9 43 26 10 30 0 0.777 1.000 1.000 436 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(2), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(1), MTR(22), SRM(2), TAT(9) 16605481 120 97 120 40 18 44 22 11 25 0 0.623 1.000 1.000 437 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(10), CALM1(3), CALM2(1), CAPN2(5), CAPNS1(1), CAPNS2(2), EP300(11), HDAC1(4), HDAC2(8), MEF2D(4), NFATC1(9), NFATC2(15), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), SYT1(6) 19557403 109 97 106 40 21 40 13 9 26 0 0.713 1.000 1.000 438 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), WASL(7) 10832772 110 96 98 32 8 42 24 10 25 1 0.670 1.000 1.000 439 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), ACO2(3), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), PC(9), PCK1(21), SDHA(8), SDHB(1), SUCLA2(5), SUCLG1(5), SUCLG2(1) 16611796 111 96 110 46 18 38 12 18 25 0 0.898 1.000 1.000 440 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(5), B3GAT2(10), CHPF(10), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST3(1), CHST7(2), CHSY1(5), DSE(19), UST(5), XYLT1(44), XYLT2(3) 11111541 117 96 115 48 29 31 28 12 17 0 0.774 1.000 1.000 441 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELE(17), SELL(9) 9773661 113 96 111 31 6 54 27 9 17 0 0.440 1.000 1.000 442 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(26), CREM(3), FHL5(15), FSHB(4), FSHR(37), GNAS(29), XPO1(12) 7620498 126 95 122 42 24 54 23 10 14 1 0.784 1.000 1.000 443 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(5), ELK1(3), EPO(6), EPOR(2), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PLCG1(7), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8) 17270267 114 95 109 24 19 34 26 15 20 0 0.0459 1.000 1.000 444 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CYP2C19(13), CYP2C9(8), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1) 24862284 115 95 114 35 13 42 28 13 19 0 0.567 1.000 1.000 445 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(3), MRPS7(3), RPL10A(2), RPL10L(16), RPL11(2), RPL13A(2), RPL14(2), RPL19(2), RPL21(1), RPL22L1(3), RPL23A(2), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL36A(2), RPL36AL(1), RPL37(2), RPL3L(8), RPL41(1), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPS10(3), RPS11(1), RPS13(1), RPS16(4), RPS18(2), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS7(1), RPSA(1) 17937359 113 93 109 32 19 36 20 12 26 0 0.367 1.000 1.000 446 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCS(1), UPB1(2) 11120123 110 93 107 31 10 51 16 13 19 1 0.410 1.000 1.000 447 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TPO(33), TYR(29) 7742906 110 93 109 43 18 40 24 12 16 0 0.774 1.000 1.000 448 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(2), GRB2(6), HRAS(2), MAPK1(2), MAPK3(3), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), RPS6KA1(6), SHC1(6) 15227173 106 92 94 26 16 44 22 9 14 1 0.110 1.000 1.000 449 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(3), GRB2(6), HRAS(2), IL3(4), IL3RA(8), JAK2(16), MAP2K1(10), MAPK3(3), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8) 14173710 112 92 107 27 17 38 28 15 14 0 0.103 1.000 1.000 450 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(6), HRAS(2), KLK2(10), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), SHC1(6), SOS1(17) 12562243 109 92 95 31 13 47 26 10 12 1 0.405 1.000 1.000 451 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(4), AP2M1(5), ARF1(1), BTK(25), EEA1(5), GSK3A(1), GSK3B(4), LYN(6), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(8) 19805791 107 91 106 27 12 31 28 12 23 1 0.225 1.000 1.000 452 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(4), CASP3(5), CASP8(6), CFLAR(2), FADD(2), JUN(3), MAP2K4(8), MAP3K3(10), MAP3K7(10), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR2C2(2), RALBP1(3), RIPK1(11), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF2(5) 21702517 106 91 105 33 9 40 24 7 26 0 0.621 1.000 1.000 453 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(10), PGAP1(8), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGW(2), PIGX(4), PIGZ(3) 19033646 112 89 111 49 13 38 27 15 19 0 0.961 1.000 1.000 454 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(26), ADRB2(4), GNAS(29), PLCE1(28), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAP2B(2) 11785893 113 89 109 38 27 44 17 8 14 3 0.570 1.000 1.000 455 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15) 7379109 110 88 109 40 12 42 26 13 16 1 0.596 1.000 1.000 456 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PPP2CA(1), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 12237886 111 88 108 38 26 39 24 7 13 2 0.751 1.000 1.000 457 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15) 7379109 110 88 109 40 12 42 26 13 16 1 0.596 1.000 1.000 458 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), PON1(3), PON2(2), PON3(5) 14444794 103 88 103 43 5 40 22 15 21 0 0.919 1.000 1.000 459 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(3), CDKN1B(5), GRB2(6), ILK(1), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), SHC1(6), SOS1(17) 15476399 109 88 96 28 8 45 25 14 17 0 0.348 1.000 1.000 460 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), ZNRD1(1) 18917469 107 87 107 34 16 35 31 9 16 0 0.696 1.000 1.000 461 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(1), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), DDOST(1), DPAGT1(5), DPM1(5), FUT8(7), MAN1A1(3), MAN1B1(4), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), RPN1(3), RPN2(4), ST6GAL1(4) 15889813 104 87 104 30 19 44 14 11 16 0 0.214 1.000 1.000 462 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), HDAC5(5), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PPARA(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), SLC2A4(4), SYT1(6), YWHAH(1) 16155923 103 87 100 22 10 38 16 12 27 0 0.0702 1.000 1.000 463 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD28(4), CD3D(2), CD3E(2), CD4(8), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6) 9079402 105 87 105 36 11 39 24 5 26 0 0.679 1.000 1.000 464 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), CASP9(6), CHUK(7), GH1(7), GHR(19), NFKB1(6), NFKBIA(4), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), YWHAH(1) 11357153 94 86 83 28 2 46 18 9 19 0 0.594 1.000 1.000 465 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(14), AMT(1), ATIC(7), DHFR(2), FTCD(8), GART(9), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3) 15191954 99 86 98 25 14 40 12 7 26 0 0.150 1.000 1.000 466 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(6), IL22(4), IL22RA1(7), IL22RA2(6), JAK1(11), JAK2(16), JAK3(10), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), TYK2(5) 14605481 94 86 94 28 8 24 21 18 23 0 0.584 1.000 1.000 467 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(8), JAK1(11), JAK2(16), JAK3(10), PIAS3(7), PTPRU(19), REG1A(20), SRC(2), STAT3(11) 12181194 107 86 105 32 12 36 21 14 24 0 0.368 1.000 1.000 468 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(10), CHUK(7), IFNG(7), IKBKB(9), IL2(7), IL4(1), JUN(3), MAP3K1(7), MAP3K5(14), MAP4K5(2), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), TNFRSF9(7), TNFSF9(3), TRAF2(5) 15554068 101 85 101 29 7 32 18 10 33 1 0.652 1.000 1.000 469 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(32), MAP2(49), PPP1CA(2), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2), PRKCE(5) 14641764 108 85 107 27 9 42 27 14 14 2 0.525 1.000 1.000 470 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(10), GCK(6), GFPT1(8), GNE(2), GNPDA1(2), GNPDA2(2), HEXA(6), HK1(12), HK2(11), HK3(22), PGM3(3), RENBP(7), UAP1(7) 13601954 98 85 98 32 23 36 13 11 15 0 0.469 1.000 1.000 471 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(10), ARHGDIB(2), BIRC2(2), BIRC3(4), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), GZMB(6), LMNA(2), LMNB1(5), LMNB2(5), PRF1(8) 15507295 110 85 109 32 4 45 24 13 24 0 0.585 1.000 1.000 472 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(15), CNR2(3), DNMT1(8), MTNR1A(15), MTNR1B(13), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), TBXA2R(1) 8843339 97 85 96 38 20 31 19 13 13 1 0.599 1.000 1.000 473 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), CHRNB1(5), CHRNG(7), MUSK(12), PIK3CA(30), PIK3R1(4), PTK2(6), PTK2B(14), RAPSN(3), SRC(2), TERT(7), YWHAH(1) 13086207 94 84 83 25 12 39 19 10 14 0 0.144 1.000 1.000 474 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2S2(3), EIF2S3(3), EIF4E(4), GSK3B(4), IGF1(4), IGF1R(8), INPPL1(11), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3) 15858521 98 84 87 22 8 47 19 9 15 0 0.116 1.000 1.000 475 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTR(22) 13939418 104 84 104 33 13 37 20 11 23 0 0.506 1.000 1.000 476 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), NCK1(5), NCKAP1(11), NTRK1(14), PIR(4), PSMA7(5), WASF1(10), WASF2(3), WASF3(13), WASL(7) 12318169 99 83 97 35 13 30 22 10 23 1 0.848 1.000 1.000 477 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(5), CASP8(6), CYCS(2), FADD(2), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(10), RAF1(6), RELA(3), RIPK1(11), SMPD1(3), TRADD(2), TRAF2(5) 16473660 96 83 93 32 11 33 27 11 14 0 0.654 1.000 1.000 478 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3D(2), CD3E(2), CXCR3(3), ETV5(6), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), JAK2(16), JUN(3), MAP2K6(5), MAPK14(4), MAPK8(2), STAT4(11), TYK2(5) 14944366 107 83 107 25 10 35 21 12 28 1 0.163 1.000 1.000 479 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(4), CAT(3), EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33) 9442451 94 83 92 38 18 32 18 12 14 0 0.781 1.000 1.000 480 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(14), AMT(1), ATIC(7), ATP6V0C(4), DHFR(2), GART(9), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3) 14411684 94 83 92 22 14 36 11 8 25 0 0.0868 1.000 1.000 481 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36) 13406889 100 82 99 30 14 39 25 10 12 0 0.487 1.000 1.000 482 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(22), CD38(4), ENPP1(14), ENPP3(19), NADSYN1(2), NMNAT1(3), NMNAT2(8), NNMT(7), NNT(11), NT5E(5), NT5M(3), QPRT(2) 11710641 100 82 98 32 11 39 11 18 21 0 0.605 1.000 1.000 483 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD28(4), CD3D(2), CD3E(2), CD8A(4), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6) 8651043 101 82 101 38 12 35 25 4 25 0 0.828 1.000 1.000 484 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(4), CD86(11), HLA-DRA(3), HLA-DRB1(5), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL2RA(6), IL4(1), IL4R(10) 10203446 102 82 98 30 10 38 15 7 31 1 0.557 1.000 1.000 485 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(26), ADRB2(4), CFTR(11), GNAS(29), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(1) 10408581 95 81 92 33 24 37 15 6 10 3 0.691 1.000 1.000 486 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(30), EP300(11), LPL(8), NCOA1(18), NCOA2(22), PPARG(8), RXRA(1) 14903897 98 81 98 19 14 34 21 11 18 0 0.0377 1.000 1.000 487 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(12), KHK(3), LCT(50), MPI(4), PGM1(3), PYGL(6), PYGM(9), TPI1(9), TREH(1) 10753455 97 80 96 27 15 44 23 5 10 0 0.133 1.000 1.000 488 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(7), ICAM1(2), ITGAL(26), ITGAM(24), ITGB2(8), SELE(17), SELL(9) 8386806 93 80 91 35 8 45 24 4 12 0 0.741 1.000 1.000 489 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), IDS(7), IDUA(1), LCT(50), NAGLU(5) 11432703 87 78 86 30 13 43 10 9 12 0 0.536 1.000 1.000 490 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREB1(2), CREBBP(30), EP300(11), NCOA3(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RARA(7), RXRA(1) 16607315 93 77 93 21 14 37 20 8 13 1 0.114 1.000 1.000 491 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(2), IARS(9), IARS2(15), ILVBL(3), LARS(14), LARS2(2), PDHA1(5), PDHA2(29), VARS(10), VARS2(2) 14999013 94 77 93 26 12 35 15 11 21 0 0.334 1.000 1.000 492 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TAL1(7), TALDO1(1), TKT(3) 16397956 89 77 89 26 12 27 19 13 18 0 0.327 1.000 1.000 493 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), PGD(2) 14510190 93 76 93 16 11 36 12 7 27 0 0.00372 1.000 1.000 494 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4) 20146303 95 76 92 30 6 39 20 8 22 0 0.648 1.000 1.000 495 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(7), CREBBP(30), EP300(11), FADD(2), HDAC3(3), IKBKB(9), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF6(6) 17978878 98 76 98 32 11 30 23 11 23 0 0.666 1.000 1.000 496 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD3E(2), CD4(8), FYN(8), HLA-DRA(3), HLA-DRB1(5), LCK(9), PTPRC(41), ZAP70(9) 7299922 87 76 83 27 10 28 15 5 29 0 0.690 1.000 1.000 497 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(3), EPX(14), LPO(7), MPO(15), MTHFR(7), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33) 9328337 90 75 89 38 19 32 16 9 14 0 0.832 1.000 1.000 498 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(20), CPT1A(11), LEP(4), LEPR(26), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5) 11717314 84 75 83 28 9 29 23 6 17 0 0.796 1.000 1.000 499 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(12), IL13(2), IL4(1), IL5(2), JUNB(1), MAF(3), MAP2K3(13), MAPK14(4), NFATC1(9), NFATC2(15), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 9567274 86 74 85 35 15 36 16 4 14 1 0.776 1.000 1.000 500 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(2), BNIP1(3), GOSR1(2), GOSR2(3), SNAP23(3), SNAP25(5), SNAP29(1), STX11(3), STX12(3), STX16(5), STX17(4), STX18(3), STX19(3), STX2(8), STX3(6), STX4(1), STX5(3), STX6(3), STX7(3), STX8(2), TSNARE1(8), USE1(2), VAMP3(1), VAMP4(2), VAMP5(1), VAMP7(4), VAMP8(1), VTI1A(2), VTI1B(1), YKT6(1) 13367893 89 74 89 26 7 28 20 12 22 0 0.501 1.000 1.000 501 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(4), CYP51A1(5), DHCR24(3), DHCR7(6), EBP(3), FDFT1(4), FDPS(5), GGCX(7), GGPS1(2), HMGCR(5), HSD17B7(3), IDI1(2), IDI2(1), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4), TM7SF2(6) 15429563 85 73 83 26 13 24 21 11 16 0 0.459 1.000 1.000 502 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3) 10651830 86 73 83 24 7 39 17 6 17 0 0.296 1.000 1.000 503 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(14), GBA(7), LPO(7), MPO(15), PRDX6(5), TPO(33) 6754499 81 73 80 38 16 28 15 9 13 0 0.939 1.000 1.000 504 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GCNT2(5), ST3GAL6(6), ST8SIA1(6) 12770463 80 72 79 25 9 37 14 8 12 0 0.293 1.000 1.000 505 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(11), JAK2(16), JAK3(10), PIAS1(2), PIAS3(7), PTPRU(19), REG1A(20), SOAT1(8) 10944552 94 72 92 28 13 33 16 11 21 0 0.392 1.000 1.000 506 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3) 12061465 80 71 78 31 15 22 19 9 15 0 0.811 1.000 1.000 507 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(4), IFNB1(7), JAK1(11), PTPRU(19), REG1A(20), STAT1(7), STAT2(6), TYK2(5) 10025136 79 70 77 18 9 37 8 10 15 0 0.0398 1.000 1.000 508 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), LTA(3), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNFAIP3(6), TNFRSF1B(2), TRAF1(2), TRAF2(5), TRAF3(4) 18085983 79 70 79 33 8 25 21 9 16 0 0.954 1.000 1.000 509 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(5), GNB1(2), GNGT1(6), HTR2C(8), PLCB1(52), TUB(11) 5767938 89 70 88 27 9 44 14 8 14 0 0.416 1.000 1.000 510 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(22), CHKA(4), PCYT1A(2), PDHA1(5), PDHA2(29), PEMT(2), SLC18A3(19) 5570894 87 69 86 35 18 38 15 3 13 0 0.756 1.000 1.000 511 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(4), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), CHST1(17), CHST2(14), CHST4(3), CHST6(7), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4) 9963065 85 69 84 41 14 31 21 6 13 0 0.950 1.000 1.000 512 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(20), ACACB(28), FASN(18), MCAT(3), OLAH(8), OXSM(5) 12381899 82 68 82 27 15 32 14 7 14 0 0.502 1.000 1.000 513 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(11), CES1(8), DDHD1(11), ESCO1(10), ESCO2(4), LIPA(2), NAT6(1), PLA1A(6), PNPLA3(4), PPME1(6), PRDX6(5) 20439259 79 68 79 24 12 24 17 13 13 0 0.565 1.000 1.000 514 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(9), APAF1(10), BCL2(5), CASP3(5), CASP9(6), CYCS(2), DAXX(8), FAS(4), FASLG(10), HSPB1(1), HSPB2(1), IL1A(4), MAPKAPK2(2), MAPKAPK3(3), TNF(2) 9129702 72 68 72 30 2 34 18 10 8 0 0.939 1.000 1.000 515 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(10), ARHGAP5(17), ARHGDIB(2), CASP1(8), CASP10(7), CASP3(5), CASP8(6), CASP9(6), CYCS(2), GZMB(6), JUN(3), PRF1(8) 10442703 80 65 80 26 3 35 16 14 12 0 0.786 1.000 1.000 516 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(6), IL2RG(5), IL4(1), IL4R(10), IRS1(20), JAK1(11), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(2) 11837408 77 65 76 28 15 28 14 11 9 0 0.700 1.000 1.000 517 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(8), ACADS(1), ACADVL(2), ACSL1(12), ACSL3(4), ACSL4(7), CPT1A(11), CPT2(3), EHHADH(13), HADHA(3), PECR(3), SCP2(4), SLC25A20(1) 13533556 76 64 75 17 11 23 13 13 16 0 0.144 1.000 1.000 518 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(48), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), YWHAH(1) 6195060 73 64 73 24 8 28 13 6 16 2 0.627 1.000 1.000 519 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(15), CD44(7), CSF1(1), FCGR3A(9), IL1B(1), IL6R(8), SELL(9), SPN(4), TGFB1(3), TGFB2(10), TNF(2), TNFRSF1B(2), TNFRSF8(11), TNFSF8(1) 10550242 83 64 81 28 8 40 15 6 14 0 0.407 1.000 1.000 520 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(9), CD3D(2), CD3E(2), GZMB(6), HLA-A(8), ICAM1(2), ITGAL(26), ITGB2(8), PRF1(8) 7018562 71 63 70 26 8 20 16 9 18 0 0.683 1.000 1.000 521 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(8), ENO1(7), GPI(8), HK1(12), PFKL(9), PGAM1(1), PGK1(4), PKLR(16), TPI1(9) 7359403 74 63 74 24 13 24 19 5 13 0 0.418 1.000 1.000 522 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(12), GPR161(6), GPR171(2), GPR18(4), GPR34(5), GPR39(6), GPR45(14), GPR65(14), GPR68(1), GPR75(5) 7970124 74 63 73 23 9 29 23 4 9 0 0.376 1.000 1.000 523 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3) 11287042 74 63 72 29 15 19 19 8 13 0 0.852 1.000 1.000 524 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(5), ARFGAP3(5), ARFGEF2(14), CLTA(1), COPA(14), GBF1(17), GPLD1(10), KDELR1(1), KDELR3(3) 13048441 71 62 71 17 7 25 18 11 10 0 0.226 1.000 1.000 525 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(9), CYP11A1(5), CYP11B2(24), CYP17A1(6), HSD11B1(9), HSD3B1(6), HSD3B2(15) 5575349 74 62 73 29 13 28 16 6 10 1 0.567 1.000 1.000 526 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(3), CALM2(1), CCL2(2), CCL4(2), CCR5(4), CXCL12(3), CXCR4(6), FOS(3), GNAQ(5), JUN(3), MAPK14(4), MAPK8(2), PLCG1(7), PRKCA(10), PTK2B(14), SYT1(6) 11118315 75 61 75 23 11 30 12 6 16 0 0.437 1.000 1.000 527 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(3), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), SDS(4), SULT1B1(10), SULT1C2(3), SULT1C4(2), SULT4A1(6) 10064685 67 61 67 24 6 32 11 5 13 0 0.790 1.000 1.000 528 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(10), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP7(3), CASP8(6), CASP9(6), DFFA(3), DFFB(4), GZMB(6), PRF1(8), SCAP(6), SREBF1(3), SREBF2(2) 14452849 75 61 75 22 1 26 18 12 18 0 0.579 1.000 1.000 529 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(5), DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(11), IDI1(2), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4) 10504983 67 60 65 20 11 18 16 7 14 1 0.497 1.000 1.000 530 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3) 5218640 69 59 68 35 20 18 15 7 9 0 0.908 1.000 1.000 531 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3) 5218640 69 59 68 35 20 18 15 7 9 0 0.908 1.000 1.000 532 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(3), AFMID(4), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2) 10822334 63 59 62 24 8 22 11 8 14 0 0.712 1.000 1.000 533 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1D(7), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(10), PER2(11), PER3(11) 13642370 71 59 69 18 8 28 17 6 11 1 0.282 1.000 1.000 534 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(29), GNB1(2), GNGT1(6), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10) 7619071 73 58 70 21 23 28 11 5 5 1 0.455 1.000 1.000 535 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), BLVRB(2), HMOX1(3), IL10(2), IL10RA(6), IL10RB(6), IL1A(4), IL6(2), JAK1(11), STAT1(7), STAT3(11), STAT5A(3), TNF(2) 9843447 62 58 62 16 4 15 15 13 15 0 0.461 1.000 1.000 536 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), DIABLO(1) 10829222 65 58 65 24 2 26 17 6 14 0 0.925 1.000 1.000 537 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(8), UBE2A(7), UBE2B(1), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2E3(6), UBE2G2(1), UBE2I(2), UBE2J1(3), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(18) 8388658 62 58 61 19 4 27 12 6 13 0 0.574 1.000 1.000 538 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PRKACA(3), PRKAR1A(2) 5210467 68 57 65 24 22 23 11 4 6 2 0.704 1.000 1.000 539 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(5), ASPH(6), COPS5(3), CREB1(2), EDN1(1), EP300(11), EPO(6), HIF1A(2), JUN(3), LDHA(10), NOS3(12), P4HB(5), VHL(1) 13589874 67 57 67 21 4 19 18 3 23 0 0.769 1.000 1.000 540 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(6) 8572537 61 57 61 31 10 22 17 5 7 0 0.945 1.000 1.000 541 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(2), ACOT11(4), ACYP2(1), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), FN3K(1), GCDH(7), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1) 20889072 71 57 69 23 9 22 18 8 14 0 0.706 1.000 1.000 542 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3), SHMT1(2) 12868967 66 57 65 28 9 28 8 8 12 1 0.858 1.000 1.000 543 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(6) 8067073 60 56 60 29 7 21 18 5 9 0 0.925 1.000 1.000 544 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(30), EP300(11), ESR1(12), MAPK1(2), MAPK3(3), PELP1(10), SRC(2) 11815841 70 56 70 17 14 25 17 2 12 0 0.147 1.000 1.000 545 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(4), FOSL2(3), IFNAR1(4), IFNAR2(7), IFNB1(7), MAPK8(2), NFKB1(6), RELA(3), TNFRSF11A(9), TNFSF11(5), TRAF6(6) 8948107 59 56 59 15 4 22 14 6 13 0 0.397 1.000 1.000 546 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(3), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2) 10332673 59 55 58 22 6 20 11 8 14 0 0.710 1.000 1.000 547 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(9), ANKRD1(6), CYR61(2), DUSP14(2), EIF4E(4), IFNG(7), IFRD1(4), IL1A(4), IL1R1(2), JUND(1), MYOG(1), NR4A3(7), WDR1(9) 8580866 58 55 58 17 4 19 15 8 11 1 0.607 1.000 1.000 548 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 549 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), TNFAIP3(6), TRAF3(4), TRAF6(6) 14639467 59 54 59 28 5 18 14 7 15 0 0.986 1.000 1.000 550 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 551 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2) 12120625 63 54 62 24 9 26 8 8 11 1 0.705 1.000 1.000 552 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(15), AGT(4), AGTR1(9), AGTR2(6), BDKRB2(3), KNG1(9), NOS3(12), REN(6) 7816341 64 53 64 32 8 31 11 6 8 0 0.896 1.000 1.000 553 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(5), CDKN1A(2), EPO(6), EPOR(2), GRIN1(9), HIF1A(2), JAK2(16), NFKB1(6), NFKBIA(4), RELA(3), SOD2(6) 10072951 61 53 60 19 3 20 18 5 15 0 0.684 1.000 1.000 554 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(5), ACOX3(8), FADS2(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3) 8123278 67 53 67 24 6 28 17 8 8 0 0.710 1.000 1.000 555 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(16), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(5) 9257582 58 53 58 21 7 15 13 12 11 0 0.789 1.000 1.000 556 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), NAT1(4), NAT2(5), XDH(18) 6470567 56 52 56 23 7 28 10 7 4 0 0.633 1.000 1.000 557 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(3), PGM3(3), TGDS(1) 9290356 61 52 61 26 17 19 11 6 8 0 0.811 1.000 1.000 558 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), SIRT1(2), SIRT2(2), SIRT5(1), SIRT7(4), VNN2(14) 9526617 56 52 54 15 8 19 13 5 11 0 0.436 1.000 1.000 559 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8) 10638297 57 52 57 19 7 19 16 5 10 0 0.686 1.000 1.000 560 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(5), ACOX3(8), ELOVL2(6), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(18), HADHA(3), HSD17B12(4), PECR(3), SCD(3) 11182281 57 51 57 14 9 23 10 8 7 0 0.171 1.000 1.000 561 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(4), CTSD(3), ESR1(12), GREB1(31), HSPB1(1), HSPB2(1), MTA1(6), MTA3(2), PDZK1(3), TUBA8(1) 8607341 64 51 63 25 13 19 15 3 14 0 0.632 1.000 1.000 562 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(2), GGT1(1), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), PAPSS1(5), PAPSS2(10), SCLY(4), SEPHS1(4) 9934310 56 51 56 27 7 23 10 5 11 0 0.943 1.000 1.000 563 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), PGM1(3), PGM3(3), TGDS(1) 8218088 59 51 59 25 17 19 11 5 7 0 0.831 1.000 1.000 564 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), CREM(3), FOS(3), JUN(3), MAPK3(3), OPRK1(12), POLR2A(11), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2) 10358187 61 50 61 27 11 23 14 6 6 1 0.926 1.000 1.000 565 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(6), DHFR(2), HPRT1(1), IMPDH1(7), MTHFD2(2), OAZ1(1), POLB(4), POLD1(7), POLG(12), PRPS2(4), RRM1(6), SRM(2) 9912415 56 50 56 13 8 19 11 9 9 0 0.223 1.000 1.000 566 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(4), MMP2(24), MMP9(10), RECK(9), TIMP1(1), TIMP2(2), TIMP3(4), TIMP4(4) 6044842 60 50 60 24 9 22 15 4 10 0 0.792 1.000 1.000 567 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(9), LARS(14), LARS2(2), PDHA1(5), PDHA2(29) 8106531 62 50 62 19 8 26 9 7 12 0 0.669 1.000 1.000 568 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMD14(2), RPN1(3), RPN2(4), UBE2A(7), UBE3A(18) 10426013 56 49 56 13 5 22 14 9 6 0 0.258 1.000 1.000 569 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(10), CKM(4), EIF4E(4), FBL(8), LDHA(10), LDHB(4), LDHC(6), MAPK14(4), NCL(10) 7183673 60 49 60 18 9 24 8 7 12 0 0.530 1.000 1.000 570 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(10), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), HSD3B7(7), PON1(3), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 7249371 51 48 51 18 5 24 11 3 8 0 0.583 1.000 1.000 571 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(5), ACO2(3), ACSS1(5), ACSS2(4), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SUCLA2(5) 10748299 52 48 52 19 5 16 5 10 16 0 0.710 1.000 1.000 572 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(4), IFNAR2(7), IFNB1(7), JAK1(11), STAT1(7), STAT2(6), TYK2(5) 8678322 49 47 49 12 4 19 9 9 8 0 0.319 1.000 1.000 573 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(10), BAK1(3), BAX(3), BCL10(4), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), CASP9(6), CES1(8) 8626031 48 47 48 22 5 22 11 6 4 0 0.970 1.000 1.000 574 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMC2(3), PSMD1(8), PSMD11(7), PSMD12(4), PSMD13(4), PSMD2(3), PSMD6(2) 12929204 53 45 53 10 5 27 10 5 6 0 0.117 1.000 1.000 575 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), IDI1(2), LSS(10), MVD(2), MVK(4), NQO2(3), PMVK(2), SQLE(4) 8778102 47 44 45 18 9 11 11 8 8 0 0.787 1.000 1.000 576 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(2), FH(13), IDH2(2), MDH1(3), OGDH(10), SDHA(8), SUCLA2(5) 7617727 46 44 45 16 7 14 7 6 12 0 0.607 1.000 1.000 577 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), KARS(8) 5621956 50 44 50 17 5 25 9 7 4 0 0.754 1.000 1.000 578 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), GRB2(6), HRAS(2), PTK2B(14), SHC1(6), SOS1(17), SRC(2) 7080935 49 43 47 14 9 15 13 6 6 0 0.461 1.000 1.000 579 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(12), GAD1(7), HDC(16), PNMT(1), TH(7), TPH1(8) 4758284 51 43 51 18 10 20 9 3 9 0 0.524 1.000 1.000 580 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(11), LDLR(9), MBTPS1(7), MBTPS2(7), SCAP(6), SREBF1(3), SREBF2(2) 9331112 45 43 45 14 5 14 13 4 7 2 0.572 1.000 1.000 581 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(5), GSS(4), NFKB1(6), NOX1(8), RELA(3), SOD1(1), TNF(2), XDH(18) 8029467 47 42 47 21 3 22 11 6 5 0 0.903 1.000 1.000 582 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CSK(2), GRB2(6), PRKCA(10), PTPRA(11), SRC(2) 7390964 46 42 46 18 8 17 8 5 8 0 0.752 1.000 1.000 583 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(2), CAPNS1(1), CAPNS2(2), CDK5(3), CDK5R1(3), CSNK1A1(2), CSNK1D(7), GSK3B(4), MAPT(15), PPP2CA(1) 7346627 49 41 49 19 8 22 9 4 6 0 0.785 1.000 1.000 584 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), WASF1(10), WASL(7) 6550870 45 41 45 19 4 13 13 5 10 0 0.933 1.000 1.000 585 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(4), MAPK8(2), NFKB1(6), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFSF13B(1), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6) 11647677 48 41 48 26 5 13 9 7 14 0 0.996 1.000 1.000 586 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), ACO2(3), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SDHB(1), SUCLA2(5) 7200223 41 39 41 15 3 14 3 8 13 0 0.715 1.000 1.000 587 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(2), ALAS2(6), CPO(4), FECH(4), GATA1(6), HBA2(2), HBB(9), HMBS(5), UROS(2) 6361596 41 38 41 25 2 21 8 3 7 0 0.992 1.000 1.000 588 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(5), CASP7(3), DFFA(3), DFFB(4), GZMB(6), HMGB1(2), TOP2A(10), TOP2B(10) 7110700 43 38 43 10 1 10 11 5 16 0 0.625 1.000 1.000 589 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(2), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(11), HMGCS2(7), OXCT1(7), OXCT2(2) 5814519 38 36 38 15 3 11 12 3 8 1 0.896 1.000 1.000 590 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4) 6322492 39 36 38 22 6 13 9 2 9 0 0.970 1.000 1.000 591 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(18), GNA12(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2) 8129650 38 34 38 11 5 15 10 4 4 0 0.637 1.000 1.000 592 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(4), FUT2(1), FUT9(15), GCNT2(5), ST8SIA1(6) 4888396 34 33 33 17 3 17 6 3 5 0 0.836 1.000 1.000 593 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHB(4), LDHC(6) 5511713 35 33 35 12 4 13 5 4 9 0 0.720 1.000 1.000 594 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(5), FMOD(3), KERA(7), LUM(17) 2934698 38 33 38 12 3 10 14 5 6 0 0.634 1.000 1.000 595 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(7), EIF2S2(3), EIF2S3(3), EIF5(1), GSK3B(4), PPP1CA(2) 9270131 32 32 32 11 2 14 5 3 8 0 0.825 1.000 1.000 596 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(14), BCKDK(2), CBS(1), CTH(2), MUT(13) 3908921 32 32 31 15 3 11 6 4 8 0 0.928 1.000 1.000 597 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(5), CD36(4), FOS(3), FYN(8), JUN(3), MAPK14(4), THBS1(8) 5972133 35 31 35 10 5 11 6 2 11 0 0.591 1.000 1.000 598 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), CYCS(2), GPD2(9), NDUFA1(2), SDHA(8), SDHB(1), SDHD(3), UQCRC1(2) 5355877 31 30 30 17 8 11 8 0 4 0 0.982 1.000 1.000 599 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(9), NR0B2(3), NR1H3(4), NR1H4(14), RXRA(1) 4348769 34 30 34 13 7 13 9 2 3 0 0.640 1.000 1.000 600 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(1), APOBEC2(1), APOBEC3A(3), APOBEC3B(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(5), APOBEC4(7) 5940270 32 30 31 14 5 12 4 4 7 0 0.870 1.000 1.000 601 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(7), PRKCA(10), PTK2B(14) 5418338 34 30 34 12 12 11 5 2 4 0 0.550 1.000 1.000 602 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), LTB4R(5), P2RY1(4), P2RY2(3), P2RY6(2) 4799440 31 30 31 15 10 6 6 4 5 0 0.807 1.000 1.000 603 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(2), GRIA2(28), JUND(1), PPP1R1B(1) 2959877 35 29 35 14 4 13 10 0 8 0 0.776 1.000 1.000 604 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(2), ALAS2(6), CPOX(4), FECH(4), HMBS(5), PPOX(7), UROS(2) 6125365 31 29 31 20 1 10 11 3 6 0 0.997 1.000 1.000 605 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(5), B3GALT2(4), B3GALT5(3), B3GNT5(5), FUT1(4), FUT2(1), FUT3(5), ST3GAL3(4), ST3GAL4(4) 5787730 35 29 35 10 8 12 7 3 5 0 0.362 1.000 1.000 606 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4) 13355738 33 29 33 15 2 10 9 4 8 0 0.957 1.000 1.000 607 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(4), CASP8(6), FADD(2), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5) 6647115 34 29 34 10 4 10 12 4 4 0 0.525 1.000 1.000 608 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(10), EPHX2(3), HSD3B7(7), RDH11(4), RDH12(3), RDH13(1), RDH14(2) 3845148 30 27 30 12 5 15 6 1 3 0 0.650 1.000 1.000 609 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(2), MDH1(3), ME1(3), PC(9), PDHA1(5), SLC25A11(3) 7432397 28 27 28 11 4 7 4 9 4 0 0.739 1.000 1.000 610 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(11), CES1(8), ESD(2) 4884444 27 25 27 10 6 10 4 3 4 0 0.528 1.000 1.000 611 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(16), SNAP25(5) 2633838 26 25 26 11 4 8 5 3 6 0 0.845 1.000 1.000 612 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(3), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(6) 4525222 25 25 25 18 2 5 10 1 7 0 0.996 1.000 1.000 613 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(2), CSF1(1), IL6(2), LDLR(9), LPL(8) 4286004 24 23 24 11 5 7 4 5 3 0 0.872 1.000 1.000 614 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB10(1), PSMB5(1), PSMB6(1) 7053300 23 21 23 7 4 8 6 3 2 0 0.593 1.000 1.000 615 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(1), IL1B(1), MST1R(7), TNF(2) 5164336 13 13 13 9 1 7 0 3 2 0 0.931 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 412157 1 1 1 2 0 0 0 1 0 0 0.987 1.000 1.000