Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.214 0.251 -9999.0 0.0 -0.657 91.0 91.0 IHH -0.312 0.27 -9999.0 0.0 -0.542 296.0 296.0 SHH Np/Cholesterol/GAS1 -0.043 0.105 -9999.0 0.0 -0.284 77.0 77.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.104 0.283 77.0 -9999.0 0.0 77.0 SMO/beta Arrestin2 -0.214 0.219 -9999.0 0.0 -0.51 106.0 106.0 SMO -0.231 0.23 -9999.0 0.0 -0.531 112.0 112.0 AKT1 -0.095 0.106 -9999.0 0.0 -0.336 12.0 12.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.032 -9999.0 0.0 -0.504 2.0 2.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.227 0.226 -9999.0 0.0 -0.51 119.0 119.0 STIL -0.197 0.22 -9999.0 0.0 -0.481 145.0 145.0 DHH N/PTCH2 -0.026 0.092 -9999.0 0.0 -0.353 38.0 38.0 DHH N/PTCH1 -0.194 0.198 -9999.0 0.0 -0.5 97.0 97.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.027 0.131 -9999.0 0.0 -0.5 37.0 37.0 PTHLH -0.277 0.289 -9999.0 0.0 -0.774 91.0 91.0 determination of left/right symmetry -0.227 0.226 -9999.0 0.0 -0.51 119.0 119.0 PIK3R1 0.009 0.022 -9999.0 0.0 -0.5 1.0 1.0 skeletal system development -0.275 0.286 -9999.0 0.0 -0.765 91.0 91.0 IHH N/Hhip -0.37 0.259 -9999.0 0.0 -0.498 386.0 386.0 DHH N/Hhip -0.215 0.197 -9999.0 0.0 -0.378 293.0 293.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.227 0.226 -9999.0 0.0 -0.51 119.0 119.0 pancreas development -0.267 0.253 -9999.0 0.0 -0.499 280.0 280.0 HHAT 0.008 0.032 -9999.0 0.0 -0.5 2.0 2.0 PI3K -0.001 0.016 -9999.0 0.0 -0.353 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.086 -9999.0 0.0 -0.5 15.0 15.0 somite specification -0.227 0.226 -9999.0 0.0 -0.51 119.0 119.0 SHH Np/Cholesterol/PTCH1 -0.181 0.2 -9999.0 0.0 -0.469 117.0 117.0 SHH Np/Cholesterol/PTCH2 -0.035 0.09 -9999.0 0.0 -0.264 69.0 69.0 SHH Np/Cholesterol/Megalin -0.109 0.151 -9999.0 0.0 -0.295 190.0 190.0 SHH -0.032 0.126 -9999.0 0.0 -0.353 68.0 68.0 catabolic process -0.203 0.204 -9999.0 0.0 -0.502 92.0 92.0 SMO/Vitamin D3 -0.205 0.22 -9999.0 0.0 -0.515 115.0 115.0 SHH Np/Cholesterol/Hhip -0.178 0.166 -9999.0 0.0 -0.304 302.0 302.0 LRP2 -0.133 0.229 -9999.0 0.0 -0.5 144.0 144.0 receptor-mediated endocytosis -0.263 0.231 -9999.0 0.0 -0.525 181.0 181.0 SHH Np/Cholesterol/BOC -0.036 0.09 -9999.0 0.0 -0.264 70.0 70.0 SHH Np/Cholesterol/CDO -0.042 0.105 -9999.0 0.0 -0.285 76.0 76.0 mesenchymal cell differentiation 0.177 0.165 0.302 302.0 -9999.0 0.0 302.0 mol:Vitamin D3 -0.181 0.202 -9999.0 0.0 -0.472 117.0 117.0 IHH N/PTCH2 -0.178 0.165 -9999.0 0.0 -0.318 296.0 296.0 CDON -0.004 0.083 -9999.0 0.0 -0.5 14.0 14.0 IHH N/PTCH1 -0.205 0.206 -9999.0 0.0 -0.507 92.0 92.0 Megalin/LRPAP1 -0.099 0.158 -9999.0 0.0 -0.353 144.0 144.0 PTCH2 0.009 0.022 -9999.0 0.0 -0.5 1.0 1.0 SHH Np/Cholesterol -0.036 0.092 -9999.0 0.0 -0.27 68.0 68.0 PTCH1 -0.204 0.205 -9999.0 0.0 -0.504 92.0 92.0 HHIP -0.268 0.253 -9999.0 0.0 -0.5 280.0 280.0