Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.023 0.015 -9999.0 0.0 -0.225 2.0 2.0 epithelial cell differentiation -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.003 0.059 -9999.0 0.0 -0.5 7.0 7.0 ENAH 0.048 0.031 -9999.0 0.0 -0.288 1.0 1.0 EGFR -0.006 0.089 -9999.0 0.0 -0.503 16.0 16.0 EPHA2 -0.0 0.07 -9999.0 0.0 -0.5 10.0 10.0 MYO6 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.034 -9999.0 0.0 -0.291 7.0 7.0 AQP5 -0.102 0.171 -9999.0 0.0 -0.419 114.0 114.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.111 0.127 -9999.0 0.0 -0.462 1.0 1.0 EGF -0.09 0.204 -9999.0 0.0 -0.508 99.0 99.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.018 0.087 -9999.0 0.0 -0.437 21.0 21.0 cortical microtubule organization -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.005 0.031 -9999.0 0.0 -0.394 1.0 1.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.006 0.037 -9999.0 0.0 -0.258 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.037 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.028 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.005 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.008 0.032 -9999.0 0.0 -0.5 2.0 2.0 EGFR/EGFR/EGF/EGF -0.05 0.096 -9999.0 0.0 -0.458 4.0 4.0 RhoA/GDP -0.001 0.014 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.009 0.022 -9999.0 0.0 -0.499 1.0 1.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.022 -9999.0 0.0 -0.5 1.0 1.0 IGF1 -0.002 0.077 -9999.0 0.0 -0.5 12.0 12.0 DIAPH1 -0.008 0.065 -9999.0 0.0 -0.56 7.0 7.0 Wnt receptor signaling pathway 0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.005 0.031 -9999.0 0.0 -0.394 1.0 1.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.009 0.022 -9999.0 0.0 -0.5 1.0 1.0 LPP 0.034 0.019 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.005 0.037 -9999.0 0.0 -0.451 1.0 1.0 SEC6/SEC8 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.113 0.128 -9999.0 0.0 -0.47 1.0 1.0 HGF/MET -0.028 0.078 -9999.0 0.0 -0.456 4.0 4.0 HGF -0.021 0.121 -9999.0 0.0 -0.501 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.023 0.016 -9999.0 0.0 -0.226 2.0 2.0 actin cable formation 0.059 0.03 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.033 0.026 -9999.0 0.0 -0.449 1.0 1.0 KIFC3 0.028 0.019 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.027 -9999.0 0.0 -0.343 1.0 1.0 adherens junction assembly 0.045 0.037 -9999.0 0.0 -0.525 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.006 0.036 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.024 0.127 -9999.0 0.0 -0.503 34.0 34.0 PLEKHA7 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.005 0.037 -9999.0 0.0 -0.256 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.048 0.014 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.023 0.015 -9999.0 0.0 -0.225 2.0 2.0 regulation of cell-cell adhesion 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.023 0.016 -9999.0 0.0 -0.226 2.0 2.0