E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.069 -9999.0 0.0 -0.345 13.0 13.0 KLHL20 -0.002 0.051 0.164 2.0 -0.211 11.0 13.0 CYFIP2 0.016 0.04 -9999.0 0.0 -0.326 7.0 7.0 Rac1/GDP -0.011 0.06 0.328 3.0 -0.262 6.0 9.0 ENAH -0.005 0.07 -9999.0 0.0 -0.351 13.0 13.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.027 -9999.0 0.0 -0.141 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.026 -9999.0 0.0 -0.175 3.0 3.0 RAPGEF1 -0.009 0.058 -9999.0 0.0 -0.321 8.0 8.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.072 -9999.0 0.0 -0.358 13.0 13.0 CRK -0.009 0.051 -9999.0 0.0 -0.337 8.0 8.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.196 2.0 2.0 alphaE/beta7 Integrin 0.028 0.015 -9999.0 0.0 -0.229 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.003 0.066 -9999.0 0.0 -0.352 12.0 12.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.054 0.212 39.0 -0.165 7.0 46.0 PI3K -0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.018 -9999.0 0.0 -0.229 2.0 2.0 TIAM1 0.015 0.043 -9999.0 0.0 -0.326 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.045 0.02 -9999.0 0.0 -0.16 2.0 2.0 AKT1 -0.017 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.326 1.0 1.0 CDH1 0.019 0.022 -9999.0 0.0 -0.326 2.0 2.0 RhoA/GDP -0.011 0.064 0.305 4.0 -0.254 7.0 11.0 actin cytoskeleton organization 0.002 0.044 0.158 9.0 -0.157 10.0 19.0 CDC42/GDP -0.011 0.064 0.305 4.0 -0.264 7.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.013 -9999.0 0.0 -0.188 2.0 2.0 ITGB7 0.02 0.016 -9999.0 0.0 -0.326 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.021 -9999.0 0.0 -0.172 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.016 -9999.0 0.0 -0.155 2.0 2.0 mol:GDP -0.012 0.069 0.317 4.0 -0.29 9.0 13.0 CDC42/GTP/IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.06 0.228 2.0 -0.257 5.0 7.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.003 0.038 0.141 12.0 -0.147 5.0 17.0 NME1 0.047 0.085 0.324 44.0 -9999.0 0.0 44.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.001 0.055 -9999.0 0.0 -0.342 8.0 8.0 regulation of cell-cell adhesion -0.024 0.019 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.023 -9999.0 0.0 -0.093 1.0 1.0 Rap1/GTP -0.023 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.03 -9999.0 0.0 -0.175 3.0 3.0 CCND1 0.002 0.042 0.143 9.0 -0.166 7.0 16.0 VAV2 -0.01 0.127 -9999.0 0.0 -0.567 20.0 20.0 RAP1/GDP -0.019 0.045 0.194 1.0 -0.23 3.0 4.0 adherens junction assembly 0.001 0.054 -9999.0 0.0 -0.333 8.0 8.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.027 -9999.0 0.0 -0.173 2.0 2.0 E-cadherin/beta catenin 0.004 0.02 -9999.0 0.0 -0.278 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.069 -9999.0 0.0 -0.346 13.0 13.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.067 -9999.0 0.0 -0.322 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.185 2.0 2.0 ITGAE 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.365 13.0 13.0