Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.035 0.061 0.24 8.0 -0.232 30.0 38.0 KIRREL 0.016 0.045 -9999.0 0.0 -0.335 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.035 0.061 0.232 30.0 -0.24 8.0 38.0 PLCG1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.051 0.057 0.218 30.0 -0.181 8.0 38.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.041 0.161 2.0 -0.21 8.0 10.0 FYN 0.016 0.084 0.208 68.0 -0.174 8.0 76.0 mol:Ca2+ 0.048 0.055 0.272 1.0 -0.177 8.0 9.0 mol:DAG 0.049 0.056 0.276 1.0 -0.178 8.0 9.0 NPHS2 -0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.049 0.056 0.276 1.0 -0.178 8.0 9.0 regulation of endocytosis 0.037 0.049 0.197 26.0 -0.168 8.0 34.0 Nephrin/NEPH1/podocin/Cholesterol 0.041 0.054 0.204 30.0 -0.175 8.0 38.0 establishment of cell polarity 0.035 0.061 0.232 30.0 -0.24 8.0 38.0 Nephrin/NEPH1/podocin/NCK1-2 0.06 0.058 0.28 1.0 -0.167 8.0 9.0 Nephrin/NEPH1/beta Arrestin2 0.038 0.051 0.205 26.0 -0.17 8.0 34.0 NPHS1 0.041 0.083 0.332 36.0 -9999.0 0.0 36.0 Nephrin/NEPH1/podocin 0.04 0.052 0.204 30.0 -0.175 8.0 38.0 TJP1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.05 0.057 0.231 5.0 -0.179 8.0 13.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.057 0.218 29.0 -0.181 8.0 37.0 GRB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.093 0.217 61.0 -0.18 30.0 91.0 cytoskeleton organization -0.003 0.053 0.222 11.0 -0.217 8.0 19.0 Nephrin/NEPH1 0.03 0.048 0.19 30.0 -0.16 8.0 38.0 Nephrin/NEPH1/ZO-1 0.04 0.053 0.216 26.0 -0.191 8.0 34.0