Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.027 -9999.0 0.0 -0.184 9.0 9.0 epithelial cell differentiation 0.041 0.018 -9999.0 0.0 -0.159 2.0 2.0 CYFIP2 0.016 0.04 -9999.0 0.0 -0.326 7.0 7.0 ENAH -0.018 0.057 0.289 5.0 -0.229 1.0 6.0 EGFR 0.014 0.045 0.324 1.0 -0.326 8.0 9.0 EPHA2 0.014 0.048 -9999.0 0.0 -0.326 10.0 10.0 MYO6 -0.018 0.038 0.224 9.0 -9999.0 0.0 9.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.022 -9999.0 0.0 -0.196 3.0 3.0 AQP5 -0.06 0.167 0.464 3.0 -0.375 98.0 101.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.039 0.216 10.0 -9999.0 0.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.087 0.075 0.163 3.0 -0.299 1.0 4.0 EGF 0.071 0.122 0.324 91.0 -0.326 5.0 96.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.021 0.072 0.238 1.0 -0.318 25.0 26.0 cortical microtubule organization 0.041 0.018 -9999.0 0.0 -0.159 2.0 2.0 GO:0000145 -0.018 0.037 0.205 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.02 -9999.0 0.0 -0.16 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.023 -9999.0 0.0 -0.166 5.0 5.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.034 -9999.0 0.0 -0.181 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.038 0.424 2.0 -0.214 1.0 3.0 PVRL2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.04 0.433 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.044 0.035 -9999.0 0.0 -0.173 6.0 6.0 CDH1 0.019 0.022 -9999.0 0.0 -0.326 2.0 2.0 EGFR/EGFR/EGF/EGF 0.041 0.055 0.239 1.0 -0.177 11.0 12.0 RhoA/GDP 0.042 0.019 -9999.0 0.0 -0.156 2.0 2.0 actin cytoskeleton organization -0.02 0.036 0.208 9.0 -9999.0 0.0 9.0 IGF-1R heterotetramer 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.052 0.324 1.0 -0.326 11.0 12.0 DIAPH1 0.015 0.119 -9999.0 0.0 -0.549 13.0 13.0 Wnt receptor signaling pathway -0.041 0.018 0.159 2.0 -9999.0 0.0 2.0 RHOA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.033 0.025 -9999.0 0.0 -0.185 6.0 6.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.037 0.21 9.0 -9999.0 0.0 9.0 EFNA1 0.017 0.017 -9999.0 0.0 -0.326 1.0 1.0 LPP -0.021 0.038 0.208 10.0 -9999.0 0.0 10.0 Ephrin A1/EPHA2 0.027 0.034 -9999.0 0.0 -0.177 9.0 9.0 SEC6/SEC8 -0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.088 0.076 0.164 3.0 -0.304 1.0 4.0 HGF/MET 0.021 0.057 -9999.0 0.0 -0.168 35.0 35.0 HGF 0.006 0.079 0.324 4.0 -0.326 24.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.027 -9999.0 0.0 -0.185 9.0 9.0 actin cable formation 0.009 0.085 0.293 18.0 -0.249 3.0 21.0 KIAA1543 -0.02 0.028 0.175 8.0 -9999.0 0.0 8.0 KIFC3 -0.023 0.02 0.164 3.0 -9999.0 0.0 3.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.038 0.218 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.018 -9999.0 0.0 -0.159 2.0 2.0 EXOC4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.02 0.03 0.186 8.0 -9999.0 0.0 8.0 PIP5K1C -0.019 0.039 0.218 10.0 -9999.0 0.0 10.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.078 0.309 11.0 -0.26 1.0 12.0 adherens junction assembly -0.025 0.087 0.353 6.0 -0.445 9.0 15.0 IGF-1R heterotetramer/IGF1 0.031 0.034 -9999.0 0.0 -0.16 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.011 0.072 0.324 6.0 -0.326 18.0 24.0 PLEKHA7 -0.02 0.029 0.186 8.0 -9999.0 0.0 8.0 mol:GTP 0.039 0.034 -9999.0 0.0 -0.18 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.018 0.095 0.306 17.0 -9999.0 0.0 17.0 cortical actin cytoskeleton stabilization 0.009 0.027 -9999.0 0.0 -0.184 9.0 9.0 regulation of cell-cell adhesion -0.02 0.036 0.208 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.027 -9999.0 0.0 -0.185 9.0 9.0