Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	227.0	11623.0	51.0	-0.033	0.777	1000.0	-1000.0	-0.096	-1000.0
Glypican 2 network	178.0	713.0	4.0	0.093	0.137	1000.0	-1000.0	0.016	-1000.0
Angiopoietin receptor Tie2-mediated signaling	153.0	13501.0	88.0	-0.59	0.114	1000.0	-1000.0	-0.056	-1000.0
HIF-1-alpha transcription factor network	134.0	10212.0	76.0	-0.061	0.429	1000.0	-1000.0	-0.035	-1000.0
Aurora B signaling	124.0	8334.0	67.0	-0.134	0.276	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by the Hedgehog family	98.0	5132.0	52.0	-0.221	0.104	1000.0	-1000.0	-0.028	-1000.0
Endothelins	79.0	7628.0	96.0	-0.31	0.196	1000.0	-1000.0	-0.034	-1000.0
PLK1 signaling events	75.0	6437.0	85.0	-0.049	0.195	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	70.0	495.0	7.0	-0.0	0.165	1000.0	-1000.0	-0.006	-1000.0
Visual signal transduction: Cones	64.0	2461.0	38.0	-0.081	0.123	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-alpha and p38-beta	62.0	2764.0	44.0	-0.101	0.021	1000.0	-1000.0	-0.022	-1000.0
FOXA2 and FOXA3 transcription factor networks	57.0	2649.0	46.0	-0.195	0.157	1000.0	-1000.0	-0.088	-1000.0
Signaling events regulated by Ret tyrosine kinase	57.0	4732.0	82.0	-0.076	0.059	1000.0	-1000.0	-0.046	-1000.0
Fc-epsilon receptor I signaling in mast cells	56.0	5450.0	97.0	-0.095	0.021	1000.0	-1000.0	-0.045	-1000.0
BMP receptor signaling	53.0	4338.0	81.0	-0.186	0.218	1000.0	-1000.0	-0.019	-1000.0
Osteopontin-mediated events	52.0	1997.0	38.0	-0.0	0.233	1000.0	-1000.0	-0.018	-1000.0
amb2 Integrin signaling	52.0	4285.0	82.0	-0.29	0.084	1000.0	-1000.0	-0.025	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	52.0	2747.0	52.0	-0.144	0.045	1000.0	-1000.0	-0.028	-1000.0
IL4-mediated signaling events	51.0	4693.0	91.0	-0.621	0.336	1000.0	-1000.0	-0.113	-1000.0
Ephrin B reverse signaling	47.0	2267.0	48.0	-0.079	0.077	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Rods	46.0	2407.0	52.0	-0.081	0.1	1000.0	-1000.0	-0.025	-1000.0
Syndecan-1-mediated signaling events	44.0	1509.0	34.0	-0.0	0.21	1000.0	-1000.0	-0.02	-1000.0
p75(NTR)-mediated signaling	40.0	5002.0	125.0	-0.154	0.13	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	38.0	4053.0	105.0	-0.125	0.071	1000.0	-1000.0	-0.037	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	37.0	2538.0	68.0	-0.158	0.071	1000.0	-1000.0	-0.062	-1000.0
Arf6 signaling events	36.0	2269.0	62.0	-0.106	0.071	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	36.0	290.0	8.0	-0.023	0.098	1000.0	-1000.0	-0.003	-1000.0
IL23-mediated signaling events	36.0	2181.0	60.0	-0.214	0.025	1000.0	-1000.0	-0.09	-1000.0
LPA4-mediated signaling events	35.0	420.0	12.0	-0.071	-0.0	1000.0	-1000.0	-0.016	-1000.0
Integrins in angiogenesis	35.0	2968.0	84.0	-0.069	0.228	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	35.0	1803.0	51.0	-0.207	0.095	1000.0	-1000.0	-0.033	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	34.0	4175.0	120.0	-0.165	0.145	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	32.0	1995.0	61.0	-0.208	0.095	1000.0	-1000.0	-0.038	-1000.0
EGFR-dependent Endothelin signaling events	32.0	681.0	21.0	-0.027	0.071	1000.0	-1000.0	-0.029	-1000.0
Glypican 1 network	31.0	1498.0	48.0	-0.066	0.037	1000.0	-1000.0	-0.02	-1000.0
Reelin signaling pathway	31.0	1786.0	56.0	-0.037	0.049	1000.0	-1000.0	-0.022	-1000.0
TCGA08_p53	31.0	218.0	7.0	-0.022	0.019	1000.0	-1000.0	-0.009	-1000.0
IL6-mediated signaling events	31.0	2398.0	75.0	-0.148	0.056	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	30.0	3437.0	114.0	-0.248	0.163	1000.0	-1000.0	-0.046	-1000.0
Aurora A signaling	29.0	1767.0	60.0	-0.029	0.183	1000.0	-1000.0	-0.018	-1000.0
Effects of Botulinum toxin	29.0	768.0	26.0	-0.0	0.045	1000.0	-1000.0	-0.01	-1000.0
Wnt signaling	28.0	196.0	7.0	-0.021	0.04	1000.0	-1000.0	-0.01	-1000.0
HIF-2-alpha transcription factor network	27.0	1201.0	43.0	-0.132	0.137	1000.0	-1000.0	-0.032	-1000.0
Nongenotropic Androgen signaling	25.0	1316.0	52.0	-0.056	0.041	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	24.0	641.0	26.0	-0.042	0.04	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	24.0	795.0	33.0	-0.07	0.096	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	23.0	1636.0	69.0	-0.113	0.146	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	23.0	1445.0	62.0	-0.081	0.042	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	23.0	1585.0	67.0	-0.042	0.122	1000.0	-1000.0	-0.031	-1000.0
PDGFR-alpha signaling pathway	22.0	981.0	44.0	-0.191	0.04	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	22.0	1562.0	70.0	-0.143	0.123	1000.0	-1000.0	-0.033	-1000.0
Syndecan-2-mediated signaling events	21.0	1509.0	69.0	-0.049	0.053	1000.0	-1000.0	-0.03	-1000.0
Nectin adhesion pathway	21.0	1369.0	63.0	-0.047	0.052	1000.0	-1000.0	-0.037	-1000.0
FoxO family signaling	21.0	1402.0	64.0	-0.001	0.196	1000.0	-1000.0	-0.044	-1000.0
LPA receptor mediated events	21.0	2185.0	102.0	-0.056	0.085	1000.0	-1000.0	-0.052	-1000.0
ErbB2/ErbB3 signaling events	20.0	1304.0	65.0	-0.051	0.03	1000.0	-1000.0	-0.048	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	20.0	694.0	34.0	-0.035	0.06	1000.0	-1000.0	-0.025	-1000.0
Ceramide signaling pathway	19.0	1477.0	76.0	-0.019	0.071	1000.0	-1000.0	-0.025	-1000.0
Class IB PI3K non-lipid kinase events	19.0	57.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.019	-1000.0
Coregulation of Androgen receptor activity	18.0	1383.0	76.0	-0.059	0.096	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	1017.0	54.0	-0.034	0.103	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PTP1B	18.0	1377.0	76.0	-0.057	0.072	1000.0	-1000.0	-0.03	-1000.0
FAS signaling pathway (CD95)	18.0	874.0	47.0	-0.24	0.034	1000.0	-1000.0	-0.021	-1000.0
EPHB forward signaling	18.0	1562.0	85.0	-0.032	0.085	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	17.0	52.0	3.0	-0.007	0.036	1000.0	-1000.0	-0.018	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1651.0	93.0	-0.04	0.033	1000.0	-1000.0	-0.032	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	539.0	31.0	-0.039	0.028	1000.0	-1000.0	-0.043	-1000.0
BCR signaling pathway	17.0	1736.0	99.0	-0.051	0.084	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	17.0	1491.0	86.0	-0.061	0.058	1000.0	-1000.0	-0.037	-1000.0
Caspase cascade in apoptosis	16.0	1250.0	74.0	-0.03	0.088	1000.0	-1000.0	-0.027	-1000.0
IL12-mediated signaling events	16.0	1478.0	87.0	-0.132	0.057	1000.0	-1000.0	-0.07	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1353.0	85.0	-0.045	0.035	1000.0	-1000.0	-0.035	-1000.0
S1P1 pathway	15.0	550.0	36.0	-0.087	0.02	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	15.0	1920.0	125.0	-0.191	0.042	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1238.0	78.0	-0.043	0.023	1000.0	-1000.0	-0.045	-1000.0
Syndecan-3-mediated signaling events	14.0	494.0	35.0	-0.121	0.046	1000.0	-1000.0	-0.021	-1000.0
Regulation of p38-alpha and p38-beta	14.0	809.0	54.0	-0.036	0.064	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	13.0	769.0	57.0	-0.046	0.117	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	13.0	553.0	40.0	-0.062	0.059	1000.0	-1000.0	-0.029	-1000.0
IL27-mediated signaling events	13.0	664.0	51.0	-0.046	0.029	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	13.0	347.0	25.0	-0.019	0.027	1000.0	-1000.0	-0.012	-1000.0
S1P5 pathway	11.0	199.0	17.0	-0.016	0.021	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by PRL	11.0	400.0	34.0	-0.02	0.086	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by STAT5	10.0	227.0	22.0	-0.024	0.089	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events	10.0	753.0	73.0	-0.034	0.064	1000.0	-1000.0	-0.026	-1000.0
PDGFR-beta signaling pathway	10.0	1051.0	97.0	-0.032	0.052	1000.0	-1000.0	-0.038	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1261.0	136.0	-0.174	0.071	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	9.0	64.0	7.0	-0.012	0.028	1000.0	-1000.0	-0.007	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	9.0	407.0	45.0	-0.017	0.05	1000.0	-1000.0	-0.03	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	676.0	74.0	-0.088	0.071	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	9.0	668.0	74.0	-0.098	0.051	1000.0	-1000.0	-0.036	-1000.0
VEGFR1 specific signals	9.0	504.0	56.0	-0.191	0.049	1000.0	-1000.0	-0.028	-1000.0
Cellular roles of Anthrax toxin	8.0	312.0	39.0	-0.032	0.028	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	567.0	65.0	-0.137	0.048	1000.0	-1000.0	-0.028	-1000.0
mTOR signaling pathway	8.0	435.0	53.0	-0.058	0.025	1000.0	-1000.0	-0.033	-1000.0
IFN-gamma pathway	8.0	608.0	68.0	-0.029	0.064	1000.0	-1000.0	-0.038	-1000.0
ceramide signaling pathway	8.0	419.0	49.0	-0.007	0.029	1000.0	-1000.0	-0.021	-1000.0
Regulation of Telomerase	8.0	822.0	102.0	-0.02	0.1	1000.0	-1000.0	-0.032	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	132.0	17.0	-0.012	0.047	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	7.0	429.0	55.0	-0.025	0.045	1000.0	-1000.0	-0.028	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	622.0	83.0	-0.058	0.049	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	7.0	460.0	58.0	-0.092	0.049	1000.0	-1000.0	-0.028	-1000.0
Arf6 trafficking events	7.0	519.0	71.0	-0.038	0.038	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	7.0	314.0	44.0	-0.006	0.064	1000.0	-1000.0	-0.015	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	130.0	17.0	-0.003	0.032	1000.0	-1000.0	-0.015	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	184.0	28.0	-0.014	0.034	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class I	6.0	650.0	104.0	-0.035	0.048	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	6.0	372.0	58.0	-0.014	0.08	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	6.0	158.0	26.0	-0.011	0.047	1000.0	-1000.0	-0.008	-1000.0
IGF1 pathway	6.0	375.0	57.0	-0.032	0.048	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class II	5.0	387.0	75.0	-0.021	0.056	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	77.0	15.0	-0.018	0.022	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	415.0	76.0	-0.031	0.051	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	5.0	234.0	43.0	-0.014	0.039	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	4.0	90.0	22.0	-0.004	0.046	1000.0	-1000.0	-0.026	-1000.0
Arf6 downstream pathway	4.0	181.0	43.0	-0.046	0.047	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	316.0	68.0	-0.028	0.044	1000.0	-1000.0	-0.016	-1000.0
S1P3 pathway	4.0	179.0	42.0	-0.022	0.034	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	3.0	165.0	48.0	-0.017	0.046	1000.0	-1000.0	-0.019	-1000.0
Canonical NF-kappaB pathway	2.0	107.0	39.0	-0.015	0.042	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	2.0	76.0	32.0	-0.016	0.038	1000.0	-1000.0	-0.022	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	103.0	37.0	-0.024	0.05	1000.0	-1000.0	-0.02	-1000.0
Rapid glucocorticoid signaling	2.0	50.0	20.0	-0.008	0.026	1000.0	-1000.0	-0.009	-1000.0
Arf1 pathway	2.0	152.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.012	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	28.0	23.0	-0.0	0.036	1000.0	-1000.0	-0.015	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.02	0.03	1000.0	-1000.0	0.017	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	66.0	36.0	-0.037	0.039	1000.0	-1000.0	-0.022	-1000.0
Atypical NF-kappaB pathway	1.0	45.0	31.0	-0.017	0.029	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.015	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	23.0	27.0	-0.019	0.045	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.056	1000.0	-1000.0	-0.0	-1000.0
Total	3506	207508	7203	-9.5969503817	10.7058012137	131000	-131000	-3.76937230012	-131000