Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 145 (81%) 33 0.063639 0.415 0.0222 0.249 0.00023 0.00874 0.0092299 0.14 0.12241 0.606 0.71073 0.988 0.00027 0.00879 0.0038 0.0788 0.0070499 0.115 0.36514 0.905 0.02928 0.257 0.050129 0.358 CDKN2A 26 (15%) 152 0.00125 0.0285 0.0058599 0.103 0.22051 0.75 0.64594 0.982 0.44351 0.939 0.34496 0.877 0.40572 0.932 0.089309 0.534 0.50408 0.939 0.81744 1 0.21058 0.746 0.19928 0.746 NFE2L2 27 (15%) 151 0.00016 0.00866 0.00019 0.00866 0.03952 0.322 0.12853 0.606 0.12032 0.606 0.34628 0.877 9.9999e-06 0.00114 9.9999e-06 0.00114 0.02589 0.253 2e-05 0.00152 0.85206 1 0.68596 0.988 MLL2 36 (20%) 142 0.27623 0.847 0.46414 0.939 0.76163 0.988 0.26726 0.847 0.9824 1 0.93586 1 0.37705 0.905 0.73968 0.988 0.4539 0.939 0.92231 1 0.71813 0.988 0.62328 0.982 KEAP1 22 (12%) 156 0.00119 0.0285 0.00083999 0.0239 0.51473 0.939 0.58613 0.982 0.01606 0.203 0.36053 0.903 0.091269 0.534 0.02772 0.253 0.061479 0.412 0.44239 0.939 0.30822 0.847 0.4092 0.932 PTEN 14 (8%) 164 0.38788 0.92 0.3243 0.85 0.44525 0.939 0.73716 0.988 1 1 0.77111 0.988 0.62599 0.982 0.51299 0.939 0.69104 0.988 0.51092 0.939 0.30279 0.847 0.53889 0.967 PIK3CA 27 (15%) 151 0.75998 0.988 0.75068 0.988 0.32031 0.849 0.61358 0.982 0.8507 1 0.75832 0.988 0.56198 0.978 0.58764 0.982 0.71648 0.988 0.37348 0.905 1 1 0.49045 0.939 RB1 12 (7%) 166 0.28343 0.847 0.64314 0.982 0.15892 0.675 0.79386 1 0.096969 0.54 0.56783 0.981 0.58941 0.982 0.23957 0.792 0.17965 0.706 0.75352 0.988 NA NA NA NA CYP11B1 15 (8%) 163 0.30705 0.847 0.67796 0.988 0.76288 0.988 0.60158 0.982 0.671 0.988 0.44439 0.939 0.68479 0.988 0.36953 0.905 0.54308 0.967 0.97696 1 NA NA NA NA NOTCH1 14 (8%) 164 0.62677 0.982 0.60402 0.982 0.98481 1 0.060349 0.412 0.50824 0.939 0.58722 0.982 0.77079 0.988 0.39129 0.92 0.39745 0.925 0.31852 0.849 0.00489 0.0929 0.10159 0.551 ASB5 9 (5%) 169 0.59221 0.982 0.5531 0.978 0.1955 0.746 NA NA 0.45288 0.939 1 1 0.47796 0.939 0.49427 0.939 0.21593 0.746 0.33517 0.868 NA NA NA NA IRF6 6 (3%) 172 0.28876 0.847 0.44298 0.939 0.63177 0.982 0.55776 0.978 0.7965 1 0.14313 0.628 0.76309 0.988 0.74875 0.988 0.12533 0.606 0.81907 1 NA NA NA NA EP300 8 (4%) 170 0.13365 0.609 0.11712 0.606 0.15987 0.675 NA NA 1 1 0.71339 0.988 0.085799 0.529 0.082249 0.521 0.21318 0.746 0.82345 1 NA NA NA NA CPS1 24 (13%) 154 0.46894 0.939 0.2081 0.746 0.50109 0.939 1 1 0.61918 0.982 0.85711 1 0.95901 1 0.84844 1 0.13022 0.606 0.12846 0.606 0.59522 0.982 1 1 ARID1A 13 (7%) 165 0.3091 0.847 0.64414 0.982 0.2925 0.847 0.63758 0.982 0.14232 0.628 0.67396 0.988 0.17675 0.706 0.80917 1 0.52989 0.959 0.5034 0.939 NA NA NA NA SLC28A1 9 (5%) 169 0.02455 0.253 0.050249 0.358 0.03106 0.262 0.29803 0.847 0.41286 0.932 0.45844 0.939 0.04542 0.345 0.02706 0.253 0.01185 0.159 0.01703 0.204 0.2869 0.847 0.7123 0.988 POLR2B 6 (3%) 172 1 1 0.79141 1 0.29241 0.847 0.16475 0.682 1 1 0.20179 0.746 0.47613 0.939 0.3122 0.847 0.01118 0.159 0.45057 0.939 0.16739 0.682 0.21471 0.746 HRAS 5 (3%) 173 0.82912 1 0.68008 0.988 0.28925 0.847 NA NA NA NA NA NA 0.93099 1 1 1 0.097189 0.54 0.75049 0.988 NA NA NA NA PI16 7 (4%) 171 0.235 0.788 0.71824 0.988 0.42409 0.939 0.02298 0.249 0.04462 0.345 0.28722 0.847 0.73295 0.988 0.88336 1 0.72573 0.988 0.48939 0.939 NA NA NA NA