rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(8), ATR(12), CCNA1(1), CCND1(1), CCNE1(3), CDKN1A(2), CDKN2A(26), CDKN2B(1), E2F1(2), HDAC1(2), RB1(12), SKP2(2), TFDP1(3), TGFB2(3), TP53(149) 7994705 230 158 175 11 28 62 20 39 80 1 1.50e-12 <1.00e-15 <2.05e-13 2 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(7), IGF1R(1), MYC(1), POLR2A(2), PRKCA(5), RB1(12), TEP1(7), TERF1(3), TERT(3), TNKS(7), TP53(149), XRCC5(2) 7492174 200 153 147 11 23 51 17 42 66 1 9.09e-12 1.11e-15 2.05e-13 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDKN1A(2), CDKN2A(26), CFL1(2), E2F1(2), MDM2(2), NXT1(1), PRB1(5), TP53(149) 2143952 191 152 136 6 17 52 17 37 67 1 1.43e-14 1.11e-15 2.05e-13 4 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(17), DAXX(3), HRAS(5), PAX3(3), RARA(1), RB1(12), SIRT1(1), SP100(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(149) 5020302 198 150 145 11 16 54 20 42 65 1 6.75e-11 1.55e-15 2.05e-13 5 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(4), ATM(8), BAX(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), GADD45A(1), MDM2(2), RB1(12), TP53(149) 4817072 185 152 133 2 16 49 17 38 64 1 2.33e-15 2.00e-15 2.05e-13 6 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(4), ATM(8), BAX(1), BCL2L1(1), CASP7(2), CASP9(3), PRKCA(5), PTK2(6), PXN(3), STAT1(2), TLN1(6), TP53(149) 7279788 191 152 138 12 24 52 20 40 54 1 4.43e-09 2.11e-15 2.05e-13 7 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), EIF2S2(1), NFKB1(2), RELA(3), TP53(149) 2611540 157 145 105 3 10 41 17 34 54 1 1.79e-12 3.00e-15 2.05e-13 8 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(26), E2F1(2), MDM2(2), MYC(1), PIK3CA(29), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1D(1), RAC1(1), RB1(12), TBX2(3), TP53(149), TWIST1(1) 5361306 237 158 169 13 42 53 17 44 80 1 9.60e-13 3.11e-15 2.05e-13 9 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(8), BRCA1(12), CDKN1A(2), CHEK1(5), CHEK2(3), GADD45A(1), JUN(3), MAPK8(2), MDM2(2), MRE11A(1), NFKB1(2), RAD50(3), RAD51(1), RBBP8(1), RELA(3), TP53(149) 7908840 201 147 148 9 27 53 18 42 60 1 1.13e-10 3.33e-15 2.05e-13 10 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MYC(1), SP1(2), SP3(1), TP53(149), WT1(4) 1863398 159 149 107 6 9 43 18 36 52 1 2.05e-10 3.44e-15 2.05e-13 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), RB1(12), TP53(149), WEE1(4) 4677103 185 148 133 4 17 49 18 36 64 1 3.36e-13 4.00e-15 2.05e-13 12 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(1), IFNGR1(4), IFNGR2(1), IKBKB(2), JAK2(4), LIN7A(1), NFKB1(2), RB1(12), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(149), USH1C(7), WT1(4) 4825619 194 148 142 9 18 47 20 42 66 1 1.43e-11 4.00e-15 2.05e-13 13 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(18), AKT1(1), ATM(8), BAX(1), CDKN1A(2), CPB2(3), CSNK1A1(2), CSNK1D(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(2), MDM2(2), NFKBIB(1), TP53(149) 5514084 196 153 144 4 26 55 17 40 56 2 6.77e-15 4.33e-15 2.05e-13 14 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(12), CDC25C(1), CHEK1(5), CHEK2(3), TP53(149) 4260894 178 149 126 4 17 49 19 37 55 1 1.67e-11 4.88e-15 2.05e-13 15 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(12), BRCA1(12), CCNB1(2), CDC25B(2), CDC25C(1), CDKN1A(2), CHEK1(5), CHEK2(3), EP300(9), GADD45A(1), MDM2(2), MYT1(4), PRKDC(12), RPS6KA1(2), TP53(149), WEE1(4), YWHAQ(1) 11278058 231 154 178 13 31 67 22 47 63 1 5.85e-11 5.00e-15 2.05e-13 16 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(2), JUN(3), KEAP1(24), MAPK1(1), MAPK14(1), MAPK8(2), NFE2L2(28), PRKCA(5) 2338729 67 60 50 3 36 17 3 7 4 0 2.49e-05 5.90e-14 2.27e-12 17 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(12), BRCA1(12), BRCA2(12), CHEK1(5), CHEK2(3), FANCA(5), FANCC(2), FANCF(3), FANCG(2), MRE11A(1), RAD1(2), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TP53(149), TREX1(1) 11712417 225 151 173 18 35 58 21 48 62 1 1.88e-07 4.65e-10 1.69e-08 18 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(4), ATM(8), ATR(12), BAI1(11), BAX(1), CASP8(2), CASP9(3), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(1), CD82(1), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45B(1), GADD45G(1), GTSE1(4), IGF1(3), IGFBP3(2), MDM2(2), PPM1D(1), PTEN(16), RFWD2(5), RPRM(1), RRM2(1), RRM2B(3), SERPINB5(2), SESN1(2), SESN2(2), SESN3(3), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TP53(149), TSC2(5) 17283296 319 164 262 27 59 83 29 55 92 1 5.91e-12 5.55e-09 1.90e-07 19 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDKN2A(26), E2F1(2), PRB1(5) 2289648 41 39 38 2 11 10 2 2 16 0 0.00147 3.77e-06 0.000122 20 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CKS1B(1), CUL1(4), E2F1(2), RB1(12), RBX1(1), SKP2(2), TFDP1(3), UBE2M(1) 2280104 29 27 29 1 6 8 0 3 12 0 0.00869 0.00418 0.129 21 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(8), CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CREB3L3(1), CREB3L4(2), E2F1(2), E2F5(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MYC(1), MYT1(4), POLE(7), POLE2(2), PRIM1(3), RB1(12), RBL1(5), RPA1(1), RPA2(1), TFDP1(3), TFDP2(4), TNXB(20), TP53(149), WEE1(4) 20348018 297 160 242 27 48 82 22 52 92 1 5.64e-11 0.00620 0.182 22 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), E2F1(2), RB1(12), RBL1(5), TFDP1(3) 4229528 64 54 61 5 14 11 4 7 28 0 0.00238 0.00849 0.238 23 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(3), CUL1(4), E2F1(2), RB1(12), SKP2(2), TFDP1(3) 2267909 27 25 27 1 7 7 0 2 11 0 0.0107 0.0130 0.348 24 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CUL1(4), E2F1(2), FBXW7(10), RB1(12), TFDP1(3) 2194468 34 33 32 4 7 8 3 2 14 0 0.0913 0.0154 0.396 25 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(6), ILK(1), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), SHC1(2), SOS1(11) 5104711 84 65 70 9 34 15 2 19 14 0 0.00300 0.0203 0.494 26 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), HRAS(5), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RB1(12), RELA(3), TFDP1(3) 5363789 71 58 57 5 30 12 2 13 14 0 0.000227 0.0209 0.494 27 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 134908 3 3 3 1 0 1 0 2 0 0 0.809 0.0330 0.752 28 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 2339282 44 40 44 6 8 22 1 12 1 0 0.00933 0.0609 1.000 29 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 2339282 44 40 44 6 8 22 1 12 1 0 0.00933 0.0609 1.000 30 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(12), SP1(2), SP3(1) 1763653 17 17 17 1 1 3 0 2 11 0 0.119 0.0624 1.000 31 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT3(3), BPNT1(1), ILK(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PTEN(16), RBL2(7), SHC1(2), SOS1(11) 5402509 78 64 64 8 33 14 1 17 13 0 0.00188 0.0808 1.000 32 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(2), CDK7(1), CDKN1A(2), CHEK1(5), NEK1(3), WEE1(4) 1849805 17 17 17 1 7 5 1 3 1 0 0.101 0.171 1.000 33 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(13), PDXP(1), PSAT1(3) 1279971 17 16 17 2 6 5 0 5 1 0 0.134 0.208 1.000 34 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(3) 536360 10 9 10 3 5 3 0 1 1 0 0.598 0.281 1.000 35 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(28), GLS(4), GLUD1(4) 2063965 42 37 41 6 6 20 2 10 4 0 0.0532 0.308 1.000 36 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(4), PGLYRP2(2) 477868 6 5 6 0 1 4 1 0 0 0 0.150 0.314 1.000 37 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 191569 2 2 2 0 0 1 0 0 1 0 0.503 0.337 1.000 38 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), FOS(2), HRAS(5), IGF1(3), IGF1R(1), IRS1(6), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2) 6550634 85 68 70 8 38 22 2 11 12 0 0.000283 0.389 1.000 39 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), PRKCE(3) 2092435 45 38 45 9 5 17 6 11 6 0 0.202 0.399 1.000 40 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(5), SPCS1(1), SPCS3(2) 816418 10 9 10 2 2 2 2 0 4 0 0.402 0.437 1.000 41 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), GH1(2), GHR(3), HRAS(5), IGF1(3), IGF1R(1), PIK3CA(29), PIK3R1(2), SHC1(2), SOD2(1) 3519496 49 42 35 6 26 14 2 6 1 0 0.0129 0.460 1.000 42 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(1), IL12A(1), IL12B(3) 791855 6 6 6 1 3 1 0 0 2 0 0.523 0.488 1.000 43 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(5), SHC1(2), SOS1(11) 2332935 19 18 18 1 3 8 2 4 2 0 0.0380 0.490 1.000 44 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT3(3), FUT5(5), FUT6(2) 1347433 11 10 11 1 0 5 4 1 1 0 0.105 0.490 1.000 45 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), HRAS(5), IGF1R(1), IRS1(6), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), RAF1(1), SHC1(2), SOS1(11) 5026832 62 52 48 6 27 17 2 11 5 0 0.00172 0.505 1.000 46 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(2) 557526 4 4 4 0 1 1 0 2 0 0 0.314 0.574 1.000 47 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(1), PRKCA(5), TGM2(1) 1305943 10 10 10 1 2 3 1 3 1 0 0.236 0.603 1.000 48 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(3) 1145747 10 9 10 0 3 3 0 4 0 0 0.0725 0.606 1.000 49 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(5), CA12(2), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(28), GLS(4), GLS2(1), GLUD1(4), GLUL(4), HAL(2) 5030899 66 50 65 7 15 29 3 14 5 0 0.00143 0.611 1.000 50 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(29), PIK3R1(2), PLCB1(8), PLCG1(3), PRKCA(5), VAV1(7) 3403944 55 47 42 8 32 12 2 7 2 0 0.0404 0.633 1.000 51 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT2(3), TAT(1), TYR(10) 1245159 19 18 19 4 2 12 0 3 2 0 0.250 0.635 1.000 52 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ECHS1(1), HADHA(2) 1439001 10 10 10 1 0 4 1 3 2 0 0.267 0.644 1.000 53 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(1), UGDH(2), UXS1(4) 1040874 8 7 8 1 4 1 0 2 1 0 0.348 0.651 1.000 54 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3) 453710 3 3 3 1 0 2 1 0 0 0 0.744 0.682 1.000 55 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(1), SQLE(3) 859199 6 6 6 0 1 2 0 3 0 0 0.207 0.689 1.000 56 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(2), IL3(1) 804618 5 5 5 0 2 1 0 0 2 0 0.263 0.714 1.000 57 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CD80(3), CD86(3), CTLA4(1), HLA-DRA(1), HLA-DRB1(2), ICOS(2), ITK(2), LCK(3), PIK3CA(29), PIK3R1(2), PTPN11(3) 3390321 52 45 39 8 29 6 2 10 5 0 0.0589 0.736 1.000 58 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(4) 1319800 12 11 12 2 5 2 0 3 2 0 0.351 0.750 1.000 59 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(5), NFS1(2), TPK1(5) 1697224 15 14 15 2 5 4 1 3 2 0 0.243 0.775 1.000 60 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 302729 1 1 1 0 0 0 0 1 0 0 0.787 0.794 1.000 61 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(2), IL5RA(3), IL6(1) 1418962 12 11 12 2 2 6 0 1 3 0 0.271 0.801 1.000 62 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(3), HLA-DRA(1), HLA-DRB1(2), IL10(2), IL4(2) 1054491 11 10 11 3 4 1 1 3 2 0 0.512 0.803 1.000 63 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(1), GLUD1(4), GLUD2(9) 1203525 18 17 18 4 5 7 0 3 3 0 0.453 0.811 1.000 64 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), CBS(4), MUT(4) 1293204 10 9 10 0 3 3 0 1 3 0 0.0668 0.814 1.000 65 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(4) 595240 7 7 7 4 2 2 0 0 3 0 0.889 0.836 1.000 66 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(28), GATM(1), GLUD1(4), NAGS(1), OAT(1), ODC1(1), OTC(3), PYCR1(1), SMS(2) 4623209 58 47 57 9 12 22 3 11 10 0 0.0200 0.876 1.000 67 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(3), RDH11(1), RDH12(2), RDH13(1), RDH14(1) 1272837 10 9 10 2 3 3 0 3 1 0 0.329 0.914 1.000 68 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), FOS(2), HRAS(5), INSR(9), IRS1(6), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SLC2A4(2), SOS1(11), SRF(2) 6731065 92 71 77 11 38 24 2 14 14 0 0.000806 0.929 1.000 69 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(2), NFKB1(2), NOX1(2), RELA(3), TNF(1), XDH(11) 2642844 25 19 25 4 5 11 2 4 3 0 0.100 0.935 1.000 70 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(3), DHRSX(4), PON1(5), PON2(1), PON3(2), RDH11(1), RDH12(2), RDH13(1), RDH14(1) 2386466 22 17 22 3 7 4 1 7 3 0 0.0835 0.943 1.000 71 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(2) 632428 4 4 4 2 2 0 0 0 2 0 0.783 0.947 1.000 72 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(3), TAT(1) 695155 4 4 4 2 1 2 0 1 0 0 0.812 0.949 1.000 73 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), HRAS(5), KLK2(2), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), SHC1(2), SOS1(11) 4134481 64 50 50 10 30 16 3 9 6 0 0.0333 0.951 1.000 74 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(13), NRG2(2), NRG3(8), PRKCA(5), PSEN1(3) 2379756 31 30 31 6 7 11 3 4 6 0 0.251 0.959 1.000 75 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(3), AFMID(1), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3548938 27 25 27 4 10 7 1 4 5 0 0.0735 0.962 1.000 76 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(4), CDC42(1), PAK1(2), PDGFRA(7), PIK3CA(29), PIK3R1(2), RAC1(1), WASL(2) 3550818 48 41 34 7 30 9 1 7 1 0 0.0676 0.964 1.000 77 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(5), MMP14(2), MMP2(3), MMP9(6), RECK(3), TIMP2(1), TIMP4(1) 1987015 21 18 20 4 2 13 2 2 2 0 0.194 0.967 1.000 78 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(3), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3388767 26 24 26 4 10 7 1 4 4 0 0.0893 0.968 1.000 79 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(4), JAK3(7), PIAS1(5), PIAS3(3), PTPRU(7), REG1A(12), SOAT1(1) 3656481 41 32 41 7 13 8 5 10 5 0 0.0923 0.969 1.000 80 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(8), GOT2(3), LDHB(3), LDHC(3) 1794526 17 16 17 4 3 4 1 7 2 0 0.453 0.969 1.000 81 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 431229 4 4 4 2 2 1 0 1 0 0 0.841 0.972 1.000 82 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFL1(2), CFLAR(2) 1021642 6 6 6 2 1 2 0 1 2 0 0.725 0.972 1.000 83 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(1), FOSL2(1), IFNAR1(2), IFNB1(2), MAPK8(2), NFKB1(2), RELA(3), TNFRSF11A(2), TNFSF11(1), TRAF6(5) 2940852 23 20 23 3 10 9 1 1 2 0 0.136 0.972 1.000 84 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(3), CDC42(1), DLD(2), DUSP10(4), DUSP4(2), DUSP8(1), GAB1(3), GADD45A(1), GCK(5), IL1R1(1), JUN(3), MAP2K4(1), MAP2K5(1), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(4), NFATC3(6), NR2C2(3), PAPPA(7), SHC1(2), TP53(149), TRAF6(5) 13319207 239 155 186 31 46 76 19 42 55 1 1.02e-05 0.975 1.000 85 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), PER1(6) 2232341 18 16 18 3 5 6 3 3 1 0 0.253 0.975 1.000 86 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(16), PSEN1(3) 2426479 21 19 21 9 1 5 1 4 10 0 0.805 0.976 1.000 87 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5) 2697863 30 27 30 6 8 11 6 0 5 0 0.160 0.977 1.000 88 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(4), LPL(3) 1412543 12 12 12 3 5 6 0 1 0 0 0.422 0.980 1.000 89 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), GRIA2(7), JUND(2), PPP1R1B(1) 995583 11 9 11 6 1 5 1 1 3 0 0.863 0.982 1.000 90 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(1), FUT9(5), GCNT2(2), ST8SIA1(3) 1627540 11 11 11 3 4 3 0 3 1 0 0.522 0.984 1.000 91 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(5), CA12(2), CA13(1), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(28), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), HAL(2) 5626259 76 56 75 10 18 34 3 14 7 0 0.00324 0.985 1.000 92 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(9), CHKA(4), PDHA1(3), PDHA2(8), SLC18A3(8) 1839111 35 30 35 9 7 14 4 9 1 0 0.272 0.987 1.000 93 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(4), RDH5(1) 1031666 5 5 5 2 2 2 0 0 1 0 0.719 0.988 1.000 94 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2) 1837039 16 15 16 4 3 4 4 3 2 0 0.553 0.989 1.000 95 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(3), DHRSX(4), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 3971100 35 29 35 5 10 13 2 3 7 0 0.0326 0.990 1.000 96 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(7), CKM(2), FBL(2), GPT(1), LDHB(3), LDHC(3), MAPK14(1), NCL(1) 2350356 20 18 20 4 6 8 1 3 2 0 0.261 0.990 1.000 97 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), FOS(2), HRAS(5), JUN(3), KLK2(2), MAP2K1(2), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(29), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11) 5061371 68 54 53 10 36 16 2 10 4 0 0.0175 0.990 1.000 98 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(2), FYN(5), JUN(3), MAPK14(1), THBS1(1) 1948766 13 11 12 2 6 3 1 3 0 0 0.294 0.991 1.000 99 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2) 7920539 88 68 73 11 39 17 5 13 14 0 0.00398 0.991 1.000 100 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(3), BMPR1B(1), BMPR2(1) 1652105 5 5 5 1 0 2 1 2 0 0 0.581 0.992 1.000 101 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), WEE1(4) 3662407 24 22 24 3 8 9 2 3 2 0 0.147 0.992 1.000 102 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(7), APOBEC2(2), APOBEC3F(1), APOBEC4(3) 1951950 17 16 17 4 3 7 0 4 3 0 0.453 0.994 1.000 103 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(5), HDC(6), PNMT(2), TH(2), TPH1(2) 1589560 19 18 19 5 6 10 1 1 1 0 0.282 0.994 1.000 104 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(8), RXRA(2) 1443617 18 18 18 5 6 4 1 4 3 0 0.516 0.996 1.000 105 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(2), JAK2(4), JAK3(7), PIAS3(3), PTPRU(7), REG1A(12), STAT3(2) 4044532 39 32 39 7 12 9 5 7 6 0 0.0891 0.996 1.000 106 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), HMGCL(1), OXCT1(3) 897227 6 6 6 3 0 3 0 2 1 0 0.894 0.996 1.000 107 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3D(1), CD4(1) 856259 3 3 3 3 0 1 0 1 1 0 0.965 0.998 1.000 108 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(6), EGFR(7), HGS(3), TF(6), TFRC(2) 3406063 27 24 26 4 10 10 0 5 2 0 0.143 0.998 1.000 109 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST3GAL4(2), ST8SIA1(3) 2683176 25 21 25 5 7 8 1 7 2 0 0.174 0.998 1.000 110 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(18), ABCB11(6), ABCB4(8), ABCC1(5), ABCC3(2), GSTP1(1) 3806542 40 28 40 9 14 15 4 5 1 1 0.107 0.998 1.000 111 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(10), SNCAIP(3), UBE2E2(2), UBE2G1(1), UBE2G2(1), UBE2L6(1) 1698416 21 20 21 5 5 3 3 6 4 0 0.465 0.998 1.000 112 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(11), KARS(3) 1250104 16 13 16 5 2 9 1 2 2 0 0.709 0.999 1.000 113 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3D(1), GZMB(1), HLA-A(6), ICAM1(2), ITGAL(1), ITGB2(5), PRF1(1) 2307379 19 18 19 8 4 5 0 4 5 1 0.633 0.999 1.000 114 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PCYT1B(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 3725202 31 27 31 5 7 13 2 3 6 0 0.0839 0.999 1.000 115 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1R(3), TNF(1) 1722648 7 7 7 2 2 4 0 1 0 0 0.515 0.999 1.000 116 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(5), ADORA3(1), P2RY1(2), P2RY2(3), P2RY6(2) 1574980 16 13 16 5 4 8 1 2 1 0 0.245 0.999 1.000 117 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACPP(1), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), TYR(10) 2541512 31 25 31 7 4 17 2 1 7 0 0.278 0.999 1.000 118 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2110033 12 11 12 3 3 7 0 0 2 0 0.370 0.999 1.000 119 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2110033 12 11 12 3 3 7 0 0 2 0 0.370 0.999 1.000 120 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL16(5), IL1A(2), IL3(1), IL4(2), IL6(1), LTA(2), TNF(1) 2630179 24 22 24 5 7 7 1 6 3 0 0.249 0.999 1.000 121 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 1289139 6 6 6 7 1 1 1 1 2 0 0.995 0.999 1.000 122 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(3), MBTPS2(3), SCAP(5), SREBF1(2), SREBF2(3) 3140491 21 20 21 4 9 5 1 4 2 0 0.177 0.999 1.000 123 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(2), LUM(2) 963183 6 6 5 3 3 3 0 0 0 0 0.725 0.999 1.000 124 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(5), CNR2(2), DNMT1(4), MTNR1A(1), MTNR1B(9), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), TBXA2R(2) 2950758 41 36 41 10 8 17 4 11 1 0 0.142 0.999 1.000 125 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(3), PTPRC(7), ZAP70(5) 2400965 25 20 25 6 8 6 3 6 2 0 0.420 0.999 1.000 126 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(14), RANGAP1(4) 2241521 18 16 18 5 4 3 2 3 6 0 0.822 0.999 1.000 127 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(7), CYP17A1(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 1839040 25 23 25 8 5 11 0 8 1 0 0.410 1.000 1.000 128 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(4), JAK3(7), MAPK1(1), MAPK3(1), STAT3(2), TYK2(8) 3098001 25 22 25 5 6 8 1 6 4 0 0.191 1.000 1.000 129 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(2), GLS(4), GLUD1(4), OAT(1), PRODH(1) 1468000 15 14 15 5 2 6 0 5 2 0 0.713 1.000 1.000 130 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT3(3), CDKN1A(2), HRAS(5), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(29), PIK3CD(4), SHC1(2), SOS1(11) 4288230 65 52 51 13 27 21 2 10 5 0 0.0611 1.000 1.000 131 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(4), IFNGR2(1), JAK1(2), JAK2(4), STAT1(2) 2175126 14 13 14 4 7 1 2 2 2 0 0.659 1.000 1.000 132 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(12), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(5), HSD3B2(3) 2147171 25 24 25 7 8 8 1 7 1 0 0.471 1.000 1.000 133 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELE(4), SELL(2) 3220732 28 21 28 5 6 8 1 9 4 0 0.169 1.000 1.000 134 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), SDHB(2), SDS(2) 2074543 12 11 12 9 2 2 2 2 4 0 0.988 1.000 1.000 135 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2) 1495071 8 8 8 3 1 6 0 1 0 0 0.748 1.000 1.000 136 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), KARS(3) 1845412 22 18 22 7 3 9 2 5 3 0 0.749 1.000 1.000 137 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(1), ITGAM(7), ITGB2(5), SELE(4), SELL(2) 2773710 26 23 26 6 7 7 2 7 3 0 0.256 1.000 1.000 138 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PPT1(1), PPT2(1) 2245979 11 11 11 3 4 3 0 2 2 0 0.552 1.000 1.000 139 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(2), SDHA(2), SDHB(2) 1754928 9 8 9 3 4 2 0 2 1 0 0.703 1.000 1.000 140 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SDHB(2), SUCLA2(2) 2360197 15 14 15 4 5 5 1 1 3 0 0.495 1.000 1.000 141 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(2), FECH(2), PPOX(1), UROD(1), UROS(1) 2007489 7 7 7 2 3 3 0 0 1 0 0.566 1.000 1.000 142 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(2), PTPRU(7), REG1A(12), STAT1(2), STAT2(1), TYK2(8) 3304772 36 32 36 9 12 11 5 3 5 0 0.273 1.000 1.000 143 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(4), JAK1(2), JAK2(4), PLA2G2A(1), PTPRU(7), REG1A(12), STAT1(2) 3036479 33 28 33 8 14 4 6 5 4 0 0.403 1.000 1.000 144 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1), CD8A(2), IL3(1), IL6(1) 1650191 10 9 10 6 1 4 0 3 2 0 0.924 1.000 1.000 145 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(8), CARS2(1), GOT2(3), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), SDS(2), SULT1B1(4), SULT1C2(4), SULT1C4(1) 3303954 32 25 32 7 11 5 4 9 3 0 0.309 1.000 1.000 146 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP2K4(1), MAP3K1(3), MAPK10(1), MCL1(2), MDM2(2), MYC(1), NFKB1(2), PARP1(3), PRF1(1), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(149), TRADD(1), TRAF1(4) 9926909 203 152 149 31 28 54 19 41 60 1 0.000557 1.000 1.000 147 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 2226973 12 10 12 6 4 3 1 0 4 0 0.859 1.000 1.000 148 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 CPO(1), FECH(2), GATA1(3), HBB(2), UROD(1), UROS(1) 2078525 10 10 10 3 2 5 0 1 2 0 0.542 1.000 1.000 149 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(4), POLB(1), POLD1(2), POLG(2), PRPS2(2), RRM1(1) 3304059 17 15 17 3 4 5 0 5 3 0 0.233 1.000 1.000 150 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(10), AKT1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CREB1(1), GNAS(7), HRAS(5), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(11) 7675854 95 75 81 15 38 23 6 22 6 0 0.0151 1.000 1.000 151 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), MIOX(1), UGDH(2) 2252196 12 12 12 4 4 5 0 0 3 0 0.528 1.000 1.000 152 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST8SIA1(3) 2848570 23 20 23 5 6 8 1 6 2 0 0.213 1.000 1.000 153 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), IL3(1), IL4(2), IL6(1), IL7(1) 1620210 10 9 10 7 0 6 0 2 2 0 0.931 1.000 1.000 154 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(3), PRKCA(5) 1778924 11 11 11 4 3 4 2 1 1 0 0.706 1.000 1.000 155 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT3(3), BTK(7), CDKN2A(26), GSK3A(3), IARS(3), INPP5D(8), PDK1(1), PIK3CA(29), PPP1R13B(5), PTEN(16), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SOS1(11), SOS2(7), TEC(4), YWHAB(1), YWHAQ(1) 9542176 141 93 124 21 52 26 4 20 39 0 0.00436 1.000 1.000 156 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), GPI(5), HK1(2), PFKL(2), PGK1(2), PKLR(4), TPI1(3) 2444355 20 16 20 6 5 8 0 3 4 0 0.344 1.000 1.000 157 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC3(2), PSMD14(3), RPN1(1), UBE2A(2), UBE3A(6) 3424451 19 19 19 4 6 8 0 1 4 0 0.340 1.000 1.000 158 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(2), HRAS(5), IL3(1), JAK2(4), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 4680668 37 33 36 7 7 14 3 7 6 0 0.131 1.000 1.000 159 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(2), GOT2(3), PAH(3), TAT(1), YARS(1) 2200189 12 11 12 4 3 5 0 3 1 0 0.581 1.000 1.000 160 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 2708377 21 19 21 5 7 9 0 3 2 0 0.269 1.000 1.000 161 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(3), EIF2S2(1), IGF1(3), IGF1R(1), INPPL1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1) 5228879 65 55 51 11 32 10 2 8 13 0 0.0645 1.000 1.000 162 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(10), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(6), IGF1(3), IGF1R(1), IL3(1), KIT(7), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 5809382 73 58 60 13 33 17 2 15 6 0 0.0192 1.000 1.000 163 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(2), GAD1(5), GAD2(6), GGT1(1) 1529828 16 13 16 9 7 6 0 2 1 0 0.895 1.000 1.000 164 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(2), CSNK1D(2), MAPT(4) 2464708 14 14 14 4 5 5 0 0 4 0 0.581 1.000 1.000 165 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(3), ARSB(2), ARSD(1), ARSE(2), CYP11B1(15), CYP11B2(7), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3), SRD5A1(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2B15(3), UGT2B4(8) 7240661 83 61 83 14 12 37 5 23 6 0 0.0104 1.000 1.000 166 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(3) 1496006 13 12 13 6 5 5 1 1 1 0 0.728 1.000 1.000 167 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(7), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GPX6(2), GSR(4), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), OPLAH(5) 5769397 49 46 49 9 11 25 0 9 4 0 0.0295 1.000 1.000 168 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), BCL2L1(1), CASP9(3), CDC42(1), CHUK(2), H2AFX(1), HRAS(5), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RALA(3), RALBP1(1), RALGDS(1), RELA(3) 5066031 60 48 45 10 31 9 2 12 6 0 0.0441 1.000 1.000 169 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(7), GNB1(1), PRKAR1A(2) 1729256 20 19 20 7 5 5 2 6 2 0 0.733 1.000 1.000 170 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), FOS(2), HRAS(5), IL6(1), IL6R(1), IL6ST(1), JAK1(2), JAK2(4), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(3), RAF1(1), SHC1(2), SOS1(11), SRF(2), STAT3(2) 6320392 52 43 50 9 16 16 3 10 7 0 0.0660 1.000 1.000 171 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(4), HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(3) 1908433 14 12 14 7 6 4 0 2 2 0 0.907 1.000 1.000 172 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(18), GNA12(2), PRKACB(3), PRKACG(1), PRKAR2B(3) 2666246 27 25 27 6 7 13 0 6 1 0 0.308 1.000 1.000 173 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(6), ITGB1(5), KLRC1(1), KLRC3(2), KLRD1(1), MAP2K1(2), MAPK3(1), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), SYK(2), VAV1(7) 4925605 63 51 50 11 32 9 1 11 9 1 0.0528 1.000 1.000 174 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(17), EP300(9), FYN(5), IL2RG(1), IL7(1), IL7R(8), JAK1(2), JAK3(7), LCK(3), NMI(2), PIK3CA(29), PIK3R1(2), STAT5A(2) 7405427 88 63 73 15 31 21 4 23 9 0 0.0194 1.000 1.000 175 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E3(2), UBE2G1(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(6) 2775361 20 19 20 6 5 8 0 2 5 0 0.639 1.000 1.000 176 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL1A(2), IL3(1), IL4(2), IL6(1), IL7(1), LTA(2), TGFB2(3), TNF(1) 3532592 29 26 29 7 9 9 1 5 5 0 0.248 1.000 1.000 177 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3) 1619951 8 8 8 4 2 3 0 2 1 0 0.882 1.000 1.000 178 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), NAT2(2), XDH(11) 2120048 21 19 21 7 4 10 1 3 3 0 0.447 1.000 1.000 179 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(7), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), PGD(1) 4764221 37 35 37 7 8 20 0 6 3 0 0.0594 1.000 1.000 180 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(13), CD38(2), ENPP1(8), ENPP3(6), NADSYN1(7), NMNAT2(2), NNT(10), NT5E(2) 3850423 50 39 50 10 12 16 2 10 10 0 0.125 1.000 1.000 181 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(7), GNB1(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5) 2524765 26 25 26 8 8 7 1 6 4 0 0.708 1.000 1.000 182 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2764965 19 18 19 6 6 5 3 1 4 0 0.626 1.000 1.000 183 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2764965 19 18 19 6 6 5 3 1 4 0 0.626 1.000 1.000 184 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(3), HRAS(5), INSR(9), IRS1(6), JAK2(4), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RPS6KA1(2), SHC1(2), SLC2A4(2), SOS1(11), SRF(2), STAT5A(2) 8751025 94 73 80 16 35 29 6 15 9 0 0.00923 1.000 1.000 185 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 7 6 3 2 5 8 0 0.546 1.000 1.000 186 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 7 6 3 2 5 8 0 0.546 1.000 1.000 187 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 7 6 3 2 5 8 0 0.546 1.000 1.000 188 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 3086344 21 19 21 5 7 9 0 3 2 0 0.249 1.000 1.000 189 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(8), PRKCA(5), RELA(3) 2182673 18 15 18 6 5 6 2 3 2 0 0.722 1.000 1.000 190 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), ITPKA(1), ITPKB(6) 1596363 9 9 9 5 3 3 1 1 1 0 0.853 1.000 1.000 191 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLRMT(2) 3554341 14 13 14 3 4 4 0 1 5 0 0.336 1.000 1.000 192 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(7), ERBB3(4), NRG1(3), UBE2D1(1) 2703897 21 19 20 6 5 7 0 5 4 0 0.538 1.000 1.000 193 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), PIK3CA(29), PIK3CD(4), PIK3R1(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(5) 8881361 81 61 68 11 36 22 2 12 9 0 0.00183 1.000 1.000 194 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), SDS(2) 2220067 13 13 13 7 3 4 1 3 2 0 0.933 1.000 1.000 195 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3) 4248967 27 25 27 7 7 5 2 5 8 0 0.402 1.000 1.000 196 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), FPGS(2), GCH1(2), GGH(2) 1710521 14 12 14 7 5 6 0 2 1 0 0.771 1.000 1.000 197 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), CPT1A(5), LEPR(15), PRKAA2(5), PRKAB2(1), PRKAG2(4) 3837576 32 28 32 7 6 10 4 6 6 0 0.346 1.000 1.000 198 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(5), GFPT1(1), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), RENBP(2), UAP1(2) 4479741 35 28 35 8 9 14 0 5 7 0 0.228 1.000 1.000 199 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABARAP(1), GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), GPHN(2), NSF(2), UBQLN1(2) 3164391 51 42 51 12 9 17 6 12 7 0 0.322 1.000 1.000 200 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), HTR2C(5), PLCB1(8) 1895707 14 12 14 7 3 7 1 2 1 0 0.876 1.000 1.000 201 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25B(2), CDC25C(1), PRKCA(5) 2442594 10 10 10 4 3 2 2 1 2 0 0.829 1.000 1.000 202 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ARPC1A(4), CDC42(1), RAC1(1), WASF1(1), WASL(2) 2152294 12 12 11 9 5 5 0 1 1 0 0.992 1.000 1.000 203 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(2), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2B15(3), UGT2B4(8) 4657758 34 29 34 8 3 15 4 10 2 0 0.335 1.000 1.000 204 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), SEPHS1(3) 3276787 13 11 13 7 4 4 0 0 5 0 0.873 1.000 1.000 205 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IFNG(1), IL4(2), TGFB2(3), TGFBR2(3), TGFBR3(8) 2812125 18 16 18 9 7 5 0 3 3 0 0.894 1.000 1.000 206 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(2), SUCLA2(2) 2485493 13 13 13 7 2 5 1 3 2 0 0.908 1.000 1.000 207 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3D(1), FOS(2), FYN(5), HRAS(5), JUN(3), LCK(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NFKB1(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), PTPN7(1), RAC1(1), RAF1(1), RASA1(8), RELA(3), SHC1(2), SOS1(11), SYT1(4), VAV1(7), ZAP70(5) 12625808 139 87 124 21 54 38 9 21 17 0 0.00157 1.000 1.000 208 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), IL10(2), IL10RA(2), IL1A(2), IL6(1), JAK1(2), STAT1(2), STAT3(2), STAT5A(2), TNF(1) 3239749 19 18 19 6 6 6 1 2 4 0 0.482 1.000 1.000 209 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1A2(2), SULT1E1(1), SULT2A1(3) 2459677 13 13 13 6 2 5 0 4 2 0 0.827 1.000 1.000 210 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(5), GOT2(3), PAH(3), TAT(1), YARS(1), YARS2(2) 2309679 17 15 17 6 4 9 0 3 1 0 0.616 1.000 1.000 211 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25B(2), CDC25C(1), CDK7(1), SHH(2), XPO1(2) 2295546 10 10 10 4 2 2 1 4 1 0 0.861 1.000 1.000 212 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(17), EP300(9), ESR1(6), MAPK1(1), MAPK3(1), PELP1(1) 3867990 35 30 34 9 5 12 2 12 4 0 0.424 1.000 1.000 213 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF13B(2), TNFRSF17(1), TNFSF13(1), TRAF3(3), TRAF5(2), TRAF6(5) 3853892 24 21 24 8 6 6 1 5 6 0 0.710 1.000 1.000 214 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(8), EIF2AK4(7), EIF2B5(3), EIF2S2(1), EIF5(4), PPP1CA(1) 3074286 24 23 24 6 9 9 0 3 3 0 0.468 1.000 1.000 215 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(2), STAT1(2), STAT2(1), TYK2(8) 2863741 18 18 18 6 6 7 1 1 3 0 0.608 1.000 1.000 216 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(1), BAX(1), BTK(7), CAD(10), CASP10(3), CASP8(2), CD7(1), CDK2AP1(1), CSNK1A1(2), DAXX(3), EGFR(7), EPHB2(6), FADD(1), FAF1(1), FAIM2(1), IL1A(2), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MET(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NR0B2(1), PFN2(1), PTPN13(9), RALBP1(1), ROCK1(5), SMPD1(4), TNFRSF6B(1), TP53(149), TPX2(1) 19416390 258 159 205 32 34 78 22 53 70 1 8.87e-07 1.000 1.000 217 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), FOS(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3395542 24 23 23 9 7 8 0 5 4 0 0.698 1.000 1.000 218 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB8(2) 2307764 7 7 7 3 4 2 0 0 1 0 0.802 1.000 1.000 219 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 3220279 18 16 18 8 4 8 1 1 4 0 0.782 1.000 1.000 220 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), CDK5R1(1), EGR1(2), HRAS(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2165029 18 18 17 7 5 8 1 3 1 0 0.581 1.000 1.000 221 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(8), CREB1(1), CREB5(3), MAPK1(1), RAF1(1), SNX13(5) 2985230 19 18 19 7 7 5 1 3 3 0 0.785 1.000 1.000 222 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(2), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 5686152 42 35 40 9 14 13 3 7 5 0 0.186 1.000 1.000 223 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(6), JUN(3), LTA(2), MAP2K4(1), MAP3K1(3), MAPK10(1), MDM2(2), MYC(1), NFKB1(2), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(3), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TP53(149), TRADD(1), TRAF1(4), TRAF3(3) 15181256 233 156 179 34 32 60 22 48 70 1 8.31e-05 1.000 1.000 224 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(2), DFFB(2), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(4) 2467278 12 11 12 6 3 4 2 2 1 0 0.954 1.000 1.000 225 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(3), LARS(1), LARS2(3), PDHA1(3), PDHA2(8) 2655435 19 17 19 6 4 7 2 5 1 0 0.703 1.000 1.000 226 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2) 3602132 20 17 19 6 6 4 1 5 4 0 0.705 1.000 1.000 227 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(10), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(2), GNA13(1), GNAI1(3), GNB1(1), MAP3K7(2), PIK3CA(29), PIK3R1(2), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 6834498 78 60 65 15 35 19 4 15 5 0 0.0647 1.000 1.000 228 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(6), EGFR(7), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 9917603 105 77 89 16 45 25 4 16 15 0 0.00737 1.000 1.000 229 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(5), F2R(2), FGA(5), FGB(4), FGG(2), PLAT(1), PLG(2), SERPINB2(4) 3549422 28 23 28 8 4 10 4 6 4 0 0.583 1.000 1.000 230 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(4), NFKB1(2), RELA(3), SOD2(1) 3335902 17 13 17 5 2 6 2 4 3 0 0.547 1.000 1.000 231 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(28), DAO(2), EPRS(12), GATM(1), GLUD1(4), GLUD2(9), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(4), PRODH(1), PYCR1(1), RARS(4), RARS2(2) 9507485 111 75 110 21 26 44 4 18 19 0 0.0118 1.000 1.000 232 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(4), IKBKB(2), MAP3K1(3), NFKB1(2), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5) 4813758 29 25 29 8 5 8 1 8 7 0 0.552 1.000 1.000 233 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4B(5), EIF4G1(10), EIF4G2(2), EIF4G3(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5) 7345129 91 68 77 16 43 17 4 11 16 0 0.0624 1.000 1.000 234 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL2RG(1), IL4(2), IL4R(2), IRS1(6), JAK1(2), JAK3(7), RPS6KB1(1), SHC1(2), STAT6(2) 3929436 26 22 26 8 5 11 1 5 4 0 0.484 1.000 1.000 235 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), SELE(4), SELL(2), SELP(11) 4238792 46 32 46 10 11 14 2 11 8 0 0.178 1.000 1.000 236 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(5), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), FASN(2), HADHA(2), HSD17B12(2), PECR(1), SCD(1) 3804969 21 18 21 9 4 8 3 2 4 0 0.679 1.000 1.000 237 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), IDI1(1), LSS(2), MVD(1), PMVK(1), SQLE(3) 2935905 14 13 14 5 1 6 0 6 1 0 0.693 1.000 1.000 238 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), CASP9(3), CES1(2) 2975887 12 12 11 4 4 2 1 4 1 0 0.800 1.000 1.000 239 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2) 3514241 18 18 18 7 4 11 0 1 2 0 0.696 1.000 1.000 240 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CAMKK2(1), CREB1(1), SYT1(4) 3046636 16 15 16 9 3 6 4 2 1 0 0.951 1.000 1.000 241 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(5), CPT2(2), EHHADH(1), HADHA(2), PECR(1), SCP2(1), SLC25A20(1) 4455792 25 25 25 7 4 6 2 8 5 0 0.535 1.000 1.000 242 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RB1(12), RELA(3), SP1(2) 5137124 66 57 53 13 26 14 1 12 13 0 0.165 1.000 1.000 243 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18) 4432425 33 27 33 8 11 12 1 6 3 0 0.267 1.000 1.000 244 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(8), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDAN1(3), CDC14A(1), CDC14B(2), CDC20(1), CDC25B(2), CDC25C(1), CDC6(6), CDC7(3), CDH1(3), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DTX4(2), E2F1(2), E2F5(2), EP300(9), ESPL1(4), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), HDAC8(1), MAD1L1(6), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MPEG1(6), MPL(2), PLK1(2), PRKDC(12), PTTG1(2), RB1(12), RBL1(5), SKP2(2), SMAD4(5), TBC1D8(1), TFDP1(3), TP53(149), WEE1(4) 29286580 370 163 314 45 70 99 30 62 108 1 3.81e-09 1.000 1.000 245 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(3), DHRSX(4), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 4387944 13 12 13 5 5 2 0 2 4 0 0.791 1.000 1.000 246 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(2), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2) 3521600 16 16 16 7 5 6 1 2 2 0 0.799 1.000 1.000 247 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), HRAS(5), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(4), MEF2D(3), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), RPS6KA1(2), SHC1(2) 5026194 61 49 47 14 30 17 2 8 4 0 0.133 1.000 1.000 248 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(2), AP2M1(1), CALM2(1), DNM1(2), EPN1(3), EPS15(5), PICALM(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(4), SYNJ2(4), SYT1(4) 5731532 51 45 50 10 17 15 4 6 9 0 0.167 1.000 1.000 249 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC2(4), PSMC3(2), PSMD1(4), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(2) 4216158 20 17 20 8 4 9 1 3 3 0 0.808 1.000 1.000 250 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(6), BECN1(2), GABARAP(1), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNG(1), PIK3C3(5), PIK3R4(7), PRKAA2(5), ULK1(4), ULK2(5) 5589918 52 43 51 10 21 12 4 7 8 0 0.163 1.000 1.000 251 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), NSDHL(1), PMVK(1), SQLE(3) 3497369 16 15 16 6 3 6 0 6 1 0 0.741 1.000 1.000 252 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFRA(7), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 9234474 99 73 84 18 44 24 5 13 13 0 0.0344 1.000 1.000 253 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(3), ARSD(1), ARSE(2), CARM1(1), CYP11B1(15), CYP11B2(7), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(2), HSD17B7(1), HSD3B1(5), HSD3B2(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SRD5A1(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), WBSCR22(3) 13038741 141 85 141 24 27 56 11 33 14 0 0.00167 1.000 1.000 254 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGEF2(3), CLTA(1), COPA(8), GBF1(6), GPLD1(1), KDELR2(1) 4288103 22 20 22 8 10 5 0 4 3 0 0.705 1.000 1.000 255 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(6), EGFR(7), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(15), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SPRY2(1), SPRY3(4) 6619376 67 55 65 14 16 22 4 12 13 0 0.150 1.000 1.000 256 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(9), CALCR(10), CALCRL(3), CRHR1(4), CRHR2(3), ELTD1(18), EMR1(11), EMR2(4), GHRHR(4), GLP1R(1), GLP2R(5), GPR64(5), LPHN1(3), LPHN2(7), LPHN3(17), SCTR(1), VIPR2(3) 7056676 108 68 108 28 33 30 8 22 15 0 0.107 1.000 1.000 257 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT3(3), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(2), INPP5D(8), JAK1(2), JAK2(4), JAK3(7), NR0B2(1), PI3(1), PIK3CA(29), PPP1R13B(5), RPS6KB1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), STAT6(2), TYK2(8) 9782296 109 76 96 21 42 28 4 21 14 0 0.0275 1.000 1.000 258 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(19), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2) 4366068 45 36 45 12 10 13 3 13 6 0 0.318 1.000 1.000 259 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G2(2), EIF4G3(4), GHR(3), IRS1(6), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PRKCA(5), PTEN(16), RPS6KB1(1) 7463396 96 71 82 18 43 19 6 14 14 0 0.105 1.000 1.000 260 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(2), UGDH(2), UGP2(4), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), XYLB(3) 6950041 64 51 64 14 11 22 7 17 7 0 0.206 1.000 1.000 261 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(1), CHRNG(4), MUSK(2), PIK3CA(29), PIK3R1(2), PTK2(6), RAPSN(3), TERT(3) 4357633 51 43 38 14 32 10 0 6 3 0 0.228 1.000 1.000 262 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(1), ANXA1(1), CALM2(1), GNAS(7), GNB1(1), NFKB1(2), NOS3(2), NR3C1(1), PIK3CA(29), PIK3R1(2), RELA(3), SYT1(4) 4733023 58 49 45 13 29 9 4 11 5 0 0.285 1.000 1.000 263 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), CSNK1D(2), NPAS2(2), PER1(6), PER2(2), PER3(2) 4502889 26 23 26 9 7 10 3 5 1 0 0.688 1.000 1.000 264 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(3), ALDH5A1(1), CAD(10), CPS1(28), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(4), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSS(2), NADSYN1(7), PPAT(2) 8821524 105 73 104 23 21 48 5 22 9 0 0.0628 1.000 1.000 265 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(10), AKT1(1), GNAI1(3), GNB1(1), ITGAV(4), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(7), PIK3CA(29), PIK3R1(2), PLCB1(8), PRKCA(5), PTK2(6), RAC1(1), SMPD1(4), SMPD2(1) 7268583 88 66 75 20 39 22 5 19 3 0 0.123 1.000 1.000 266 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), JAK1(2), JAK3(7), JUN(3), LCK(3), MAP2K1(2), MAPK3(1), MAPK8(2), RAF1(1), SHC1(2), SOS1(11), STAT5A(2), SYK(2) 6179385 50 39 48 12 14 16 3 10 7 0 0.246 1.000 1.000 267 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(3), EBP(1), FDFT1(1), FDPS(1), GGPS1(2), HMGCR(1), HSD17B7(1), IDI1(1), IDI2(2), LSS(2), MVD(1), NSDHL(1), PMVK(1), SQLE(3), TM7SF2(1) 5112504 22 20 22 7 4 9 1 7 1 0 0.555 1.000 1.000 268 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(2), CRKL(1), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(29), PIK3R1(2), RAF1(1), SOS1(11), STAT1(2), STAT5A(2) 7435432 75 57 60 15 38 15 4 13 5 0 0.110 1.000 1.000 269 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(17), EP300(9), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 5930182 47 38 46 11 11 14 4 10 8 0 0.272 1.000 1.000 270 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(4), AKT1(1), AKT3(3), ARRB1(2), ATF2(3), ATF4(2), BDNF(1), BRAF(8), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(8), CACNA1H(5), CACNA1I(12), CACNA1S(7), CACNA2D1(11), CACNA2D2(3), CACNA2D3(3), CACNA2D4(8), CACNB1(1), CACNB2(5), CACNB3(2), CACNB4(1), CACNG2(1), CACNG3(4), CACNG4(1), CACNG6(1), CACNG7(4), CACNG8(2), CD14(2), CDC25B(2), CDC42(1), CHUK(2), CRKL(1), DAXX(3), DUSP10(4), DUSP16(2), DUSP4(2), DUSP5(5), DUSP6(2), DUSP7(1), DUSP8(1), EGF(6), EGFR(7), ELK4(1), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FLNA(14), FLNB(3), FLNC(16), FOS(2), GADD45A(1), GADD45B(1), GADD45G(1), GNA12(2), GNG12(1), HRAS(5), IKBKB(2), IL1A(2), IL1B(1), IL1R1(1), IL1R2(3), JUN(3), JUND(2), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MAPT(4), MEF2C(4), MKNK2(1), MOS(4), MRAS(2), MYC(1), NF1(22), NFATC2(5), NFATC4(2), NFKB1(2), NFKB2(2), NLK(2), NR4A1(3), NRAS(1), NTF3(3), NTRK1(4), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(7), PDGFRB(6), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PPM1A(2), PPM1B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(9), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF2(7), RASA1(8), RASA2(3), RASGRF1(7), RASGRF2(7), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS2(2), SOS1(11), SOS2(7), SRF(2), STK3(2), STK4(2), TAOK1(7), TAOK2(5), TAOK3(4), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF1A(2), TP53(149), TRAF6(5) 75847612 818 174 759 208 191 278 54 135 159 1 0.000619 1.000 1.000 271 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN4(5), AKT1(1), AKT3(3), ARHGAP5(2), BCAR1(6), BIRC2(1), BIRC3(3), BRAF(8), CAPN2(2), CAV2(1), CAV3(1), CCND1(1), CCND2(3), CCND3(1), CDC42(1), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(10), COL4A2(13), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(6), COL6A3(13), COL6A6(20), COMP(1), CRKL(1), CTNNB1(4), DIAPH1(1), DOCK1(4), EGF(6), EGFR(7), ERBB2(3), FARP2(7), FIGF(2), FLNA(14), FLNB(3), FLNC(16), FLT1(12), FN1(19), FYN(5), HGF(10), HRAS(5), IBSP(6), IGF1(3), IGF1R(1), ILK(1), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), JUN(3), KDR(15), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(16), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(7), LAMC1(7), LAMC2(5), LAMC3(5), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(4), MYL2(2), MYL9(1), MYLK(8), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PARVB(1), PARVG(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(6), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PRKCA(5), PRKCG(9), PTEN(16), PTK2(6), PXN(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(32), ROCK1(5), ROCK2(3), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TLN1(6), TLN2(14), TNC(14), TNN(21), TNR(26), TNXB(20), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCL(2), VEGFC(6), VWF(17), ZYX(1) 98378517 1034 174 1016 291 288 379 61 148 155 3 0.0556 1.000 1.000 272 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(9), APC2(2), AXIN2(2), BTRC(1), CACYBP(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CCND1(1), CCND2(3), CCND3(1), CER1(2), CHD8(9), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(2), CTBP1(2), CTNNB1(4), CUL1(4), CXXC4(1), DAAM1(1), DAAM2(7), DKK1(4), DKK2(1), DKK4(1), DVL1(2), DVL3(2), EP300(9), FBXW11(1), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(6), MAP3K7(2), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NKD1(2), NKD2(2), NLK(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PORCN(2), PPARD(2), PPP2R1A(8), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRICKLE1(7), PRICKLE2(3), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PSEN1(3), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(3), SENP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(2), SMAD3(1), SMAD4(5), TBL1XR1(2), TBL1Y(2), TCF7(1), TCF7L2(1), TP53(149), VANGL1(1), VANGL2(2), WIF1(5), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 42805750 475 170 421 113 93 172 40 75 94 1 0.00636 1.000 1.000 273 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(9), ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA2B(6), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), C5AR1(3), CALCR(10), CALCRL(3), CCKAR(2), CCKBR(2), CGA(2), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CNR1(5), CNR2(2), CRHR1(4), CRHR2(3), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(2), FSHR(15), GABBR1(5), GABBR2(3), GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), GABRB1(4), GABRB2(6), GABRB3(11), GABRD(2), GABRE(4), GABRG1(15), GABRG2(4), GABRG3(10), GABRP(3), GABRQ(7), GABRR1(4), GABRR2(4), GALR1(5), GH1(2), GH2(4), GHR(3), GHRHR(4), GHSR(4), GLP1R(1), GLP2R(5), GLRA1(2), GLRA2(5), GLRA3(3), GLRB(3), GPR156(4), GPR35(1), GPR50(5), GPR63(4), GPR83(2), GRIA1(9), GRIA2(7), GRIA3(10), GRIA4(10), GRID1(14), GRID2(15), GRIK1(5), GRIK2(9), GRIK3(10), GRIK4(4), GRIK5(2), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRIN3A(9), GRIN3B(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM6(6), GRM7(10), GRM8(14), GRPR(3), GZMA(4), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HRH4(4), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(3), LEPR(15), LHB(1), LHCGR(9), LTB4R2(1), MAS1(3), MC1R(1), MC2R(2), MC3R(2), MC4R(2), MC5R(3), MCHR1(2), MCHR2(6), MLNR(2), MTNR1A(1), MTNR1B(9), NMBR(3), NMUR2(2), NPBWR1(4), NPBWR2(3), NPFFR2(8), NPY1R(3), NPY2R(4), NPY5R(4), NR3C1(1), NTSR1(4), NTSR2(3), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(6), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), P2RY1(2), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(2), PARD3(7), PRL(1), PRLHR(2), PRLR(6), PRSS1(4), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(5), PTGIR(1), PTH2R(6), RXFP1(8), RXFP2(3), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(5), TAAR2(4), TAAR5(5), TAAR6(5), TAAR8(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), THRA(1), THRB(2), TRHR(2), TRPV1(3), TSHR(5), VIPR2(3) 58501687 894 169 891 296 191 369 76 150 108 0 0.0257 1.000 1.000 274 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(2), COL11A1(45), COL11A2(13), COL17A1(4), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(10), COL4A2(13), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(6), COL6A3(13), COL6A6(20), COMP(1), DES(3), DSC1(8), DSC2(1), DSC3(6), DSG1(9), DSG2(3), DSG3(4), DSG4(8), FN1(19), GJA1(4), GJA10(7), GJA4(1), GJA5(1), GJA8(3), GJA9(4), GJB2(1), GJB4(3), GJC1(2), GJC2(1), GJD2(2), GJD4(2), IBSP(6), INA(2), ITGA6(7), ITGB4(8), KRT1(1), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(3), KRT17(2), KRT18(2), KRT2(5), KRT20(2), KRT23(4), KRT24(3), KRT27(2), KRT28(2), KRT3(2), KRT31(2), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT39(1), KRT4(2), KRT40(2), KRT5(1), KRT6A(2), KRT6B(3), KRT6C(1), KRT71(3), KRT72(4), KRT73(6), KRT74(2), KRT75(1), KRT76(3), KRT77(4), KRT79(2), KRT8(1), KRT81(3), KRT82(2), KRT83(2), KRT84(4), KRT85(2), KRT86(1), KRT9(2), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(16), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(7), LAMC1(7), LAMC2(5), LAMC3(5), NES(13), PRPH(3), RELN(32), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(20), VIM(7), VWF(17) 65915247 739 168 738 219 197 284 53 103 100 2 0.166 1.000 1.000 275 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY7(7), ADCY8(18), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), AGTR1(5), ATP2A1(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(3), BST1(1), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(8), CACNA1H(5), CACNA1I(12), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(2), CD38(2), CHRM2(8), CHRM3(5), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(5), EGFR(7), ERBB2(3), ERBB3(4), ERBB4(13), F2R(2), GNA11(1), GNA14(3), GNAL(1), GNAS(7), GRIN1(1), GRIN2A(16), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), GRPR(3), HRH1(3), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), LHCGR(9), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(11), NOS3(2), NTSR1(4), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), PDE1A(2), PDE1B(3), PDE1C(12), PDGFRA(7), PDGFRB(6), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(4), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(5), RYR1(28), RYR2(116), RYR3(52), SLC25A5(1), SLC25A6(1), SLC8A1(15), SLC8A2(3), SLC8A3(4), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), TNNC1(1), TRHR(2), TRPC1(6), VDAC1(1) 71573339 858 168 853 254 189 352 54 144 118 1 0.00263 1.000 1.000 276 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(3), ANAPC1(5), ANAPC4(3), ANAPC5(5), ATM(8), ATR(12), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDC14A(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25B(2), CDC25C(1), CDC27(3), CDC6(6), CDC7(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CHEK1(5), CHEK2(3), CREBBP(17), CUL1(4), DBF4(4), E2F1(2), EP300(9), ESPL1(4), GADD45A(1), GADD45B(1), GADD45G(1), HDAC1(2), MAD1L1(6), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), PKMYT1(1), PLK1(2), PRKDC(12), PTTG1(2), RB1(12), RBL1(5), RBL2(7), RBX1(1), SFN(2), SKP1(1), SKP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(2), SMC1B(9), TFDP1(3), TGFB2(3), TP53(149), WEE1(4), YWHAB(1), YWHAQ(1) 36188500 435 167 379 60 100 115 34 71 114 1 9.70e-08 1.000 1.000 277 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(1), AKT3(3), APAF1(4), ATM(8), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), CSF2RB(6), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1A(2), IL1B(1), IL1R1(1), IL1RAP(2), IL3(1), IRAK1(4), IRAK2(1), IRAK3(4), NFKB1(2), NFKB2(2), NTRK1(4), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TP53(149), TRADD(1) 22180288 323 167 257 53 70 90 23 59 80 1 2.28e-05 1.000 1.000 278 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN4(5), AKT1(1), AKT3(3), AMOTL1(3), ASH1L(9), CASK(2), CDC42(1), CGN(4), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CSNK2A1(2), CTNNA1(2), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTTN(5), EPB41(3), EPB41L1(3), EPB41L2(3), EPB41L3(20), EXOC3(3), EXOC4(3), F11R(1), GNAI1(3), GNAI3(1), HCLS1(4), HRAS(5), IGSF5(2), INADL(13), JAM2(2), KRAS(2), LLGL1(1), LLGL2(3), MAGI1(8), MAGI2(12), MAGI3(2), MLLT4(4), MPDZ(6), MPP5(4), MRAS(2), MYH1(23), MYH10(1), MYH11(9), MYH13(12), MYH14(6), MYH15(18), MYH2(31), MYH3(6), MYH4(21), MYH6(14), MYH7(13), MYH7B(6), MYH8(24), MYH9(13), MYL2(2), MYL9(1), NRAS(1), PARD3(7), PARD6A(1), PARD6G(1), PPP2R1A(8), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PTEN(16), RAB13(1), RAB3B(2), RRAS2(2), SPTAN1(4), SYMPK(9), TJAP1(4), TJP1(9), TJP2(3), TJP3(2), VAPA(1), YES1(1) 51510780 543 165 540 141 157 174 38 82 92 0 0.0286 1.000 1.000 279 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD36(1), CD44(5), CD47(2), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(10), COL4A2(13), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(6), COL6A3(13), COL6A6(20), DAG1(2), FN1(19), FNDC1(8), FNDC3A(1), GP5(4), GP6(2), GP9(2), HMMR(2), HSPG2(11), IBSP(6), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(16), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(7), LAMC1(7), LAMC2(5), LAMC3(5), RELN(32), SDC2(2), SDC3(1), SPP1(1), SV2A(3), SV2B(4), SV2C(4), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(20), VWF(17) 59383761 657 161 656 190 171 252 40 96 95 3 0.185 1.000 1.000 280 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), ANXA6(5), ARRB1(2), ATP1A4(6), ATP1B2(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1S(7), CACNB1(1), CACNB3(2), CALM2(1), CALR(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), GJA1(4), GJA4(1), GJA5(1), GJB2(1), GJB4(3), GNA11(1), GNAI3(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), ITPR1(6), ITPR2(14), ITPR3(3), KCNB1(1), KCNJ3(11), KCNJ5(2), MIB1(2), MYCBP(1), NME7(3), PEA15(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(13), RGS9(2), RYR1(28), RYR2(116), RYR3(52), SFN(2), SLC8A1(15), SLC8A3(4), USP5(2), YWHAB(1), YWHAQ(1) 50047107 608 160 604 180 134 241 40 110 82 1 0.0204 1.000 1.000 281 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(2), ACTN2(9), ACTN4(5), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(5), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(4), BAIAP2(2), BCAR1(6), BDKRB1(3), BDKRB2(3), BRAF(8), CD14(2), CDC42(1), CFL1(2), CFL2(1), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CRKL(1), CYFIP1(5), CYFIP2(6), DIAPH1(1), DIAPH2(4), DIAPH3(5), DOCK1(4), EGF(6), EGFR(7), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FN1(19), GIT1(1), GNA12(2), GNA13(1), GNG12(1), GSN(2), HRAS(5), IQGAP1(8), IQGAP2(6), IQGAP3(11), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), KRAS(2), LIMK2(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(4), MYH10(1), MYH14(6), MYH9(13), MYL2(2), MYL9(1), MYLK(8), MYLK2(3), NCKAP1(7), NCKAP1L(12), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PDGFB(1), PDGFRA(7), PDGFRB(6), PFN2(1), PFN3(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PPP1CA(1), PPP1R12B(5), PTK2(6), PXN(3), RAC1(1), RAF1(1), RDX(2), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(11), SOS2(7), SSH1(1), SSH2(8), SSH3(1), TIAM1(11), TIAM2(5), VAV1(7), VAV2(4), VAV3(1), VCL(2), WAS(3), WASF1(1), WASL(2) 73224440 627 158 609 175 195 199 27 117 88 1 0.0514 1.000 1.000 282 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(2), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CXCR4(5), DCC(15), DPYSL2(1), DPYSL5(8), EFNA3(1), EFNB1(3), EFNB2(2), EPHA1(3), EPHA2(2), EPHA3(11), EPHA4(1), EPHA5(15), EPHA6(14), EPHA7(9), EPHA8(6), EPHB1(13), EPHB2(6), EPHB3(8), EPHB4(3), EPHB6(5), FYN(5), GNAI1(3), GNAI3(1), HRAS(5), ITGB1(5), KRAS(2), L1CAM(1), LIMK2(3), LRRC4C(19), MAPK1(1), MAPK3(1), MET(4), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(5), NTN1(3), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PLXNA1(10), PLXNA2(3), PLXNA3(5), PLXNB1(3), PLXNB2(4), PLXNB3(4), PLXNC1(9), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTK2(6), RAC1(1), RASA1(8), RGS3(6), ROBO1(9), ROBO2(9), ROBO3(7), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3C(5), SEMA3D(3), SEMA3E(6), SEMA3F(2), SEMA3G(3), SEMA4A(1), SEMA4C(2), SEMA4D(1), SEMA4F(6), SEMA5A(9), SEMA5B(6), SEMA6B(1), SEMA6C(5), SEMA6D(8), SEMA7A(1), SLIT1(4), SLIT2(16), SLIT3(10), SRGAP1(5), SRGAP2(4), SRGAP3(5), UNC5A(5), UNC5B(2), UNC5C(8), UNC5D(19) 52059313 494 157 493 173 108 189 32 87 78 0 0.723 1.000 1.000 283 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ARRB1(2), ATF2(3), ATF3(1), ATF4(2), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CNN1(2), CORIN(11), CRHR1(4), DGKZ(4), FOS(2), GABPA(2), GABPB2(2), GJA1(4), GNB1(1), GNB2(1), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), GSTO1(1), GUCY1A3(7), IGFBP3(2), IGFBP6(2), IL1B(1), IL6(1), ITPR1(6), ITPR2(14), ITPR3(3), JUN(3), MIB1(2), MYL2(2), MYL4(1), MYLK2(3), NFKB1(2), NOS1(11), NOS3(2), OXTR(1), PDE4B(3), PDE4D(2), PKIB(1), PLCB3(4), PLCD1(1), PLCG1(3), PLCG2(4), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCQ(4), PRKCZ(1), PRKD1(11), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(13), RGS9(2), RYR1(28), RYR2(116), RYR3(52), SFN(2), SLC8A1(15), SP1(2), TNXB(20), USP5(2), YWHAB(1), YWHAQ(1) 46011111 538 156 532 158 132 198 39 96 72 1 0.0525 1.000 1.000 284 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CCR9(1), CCRL2(1), CHML(2), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CMKLR1(2), CNR1(5), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR17(4), GPR173(1), GPR174(6), GPR27(1), GPR35(1), GPR37(3), GPR37L1(2), GPR50(5), GPR6(2), GPR63(4), GPR83(2), GPR85(2), GPR87(4), GRPR(3), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(3), LHCGR(9), MAS1(3), MC1R(1), MC3R(2), MC4R(2), MC5R(3), MLNR(2), MTNR1A(1), MTNR1B(9), NMBR(3), NMUR2(2), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(3), OPN1SW(3), OPN3(2), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(6), OR10A5(2), OR11A1(4), OR12D3(4), OR1C1(9), OR1F1(1), OR1Q1(2), OR2H1(2), OR5V1(3), OR8B8(6), OXTR(1), P2RY1(2), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), RGR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(2) 32079932 402 149 402 151 76 171 28 81 46 0 0.247 1.000 1.000 285 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTN2(9), ACTN4(5), DES(3), DMD(34), MYBPC1(9), MYBPC3(6), MYH3(6), MYH6(14), MYH7(13), MYH8(24), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYL9(1), MYOM1(12), NEB(30), TNNI2(2), TNNI3(2), TNNT1(1), TNNT2(2), TNNT3(3), TPM1(1), TPM3(1), TTN(292), VIM(7) 36469866 488 146 486 150 127 175 34 91 57 4 0.846 1.000 1.000 286 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(2), AK2(1), AK5(7), AK7(3), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), NME4(1), NME7(3), NPR1(4), NPR2(4), NT5C1A(2), NT5C1B(1), NT5C2(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(9), PDE11A(12), PDE1A(2), PDE1C(12), PDE2A(4), PDE3B(5), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6H(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2), PPAT(2), PRIM1(3), PRIM2(4), PRPS1(2), PRPS1L1(3), PRPS2(2), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), XDH(11) 43376730 360 141 360 127 93 131 18 53 65 0 0.781 1.000 1.000 287 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT3(3), BCL2L1(1), CBL(3), CBLB(7), CCND1(1), CCND2(3), CCND3(1), CNTFR(1), CREBBP(17), CRLF2(2), CSF2RA(7), CSF2RB(6), CSF3R(7), EP300(9), EPOR(2), GH1(2), GH2(4), GHR(3), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL19(1), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), JAK1(2), JAK2(4), JAK3(7), LEPR(15), LIFR(3), MPL(2), MYC(1), OSMR(6), PIAS1(5), PIAS2(2), PIAS3(3), PIAS4(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(6), PTPN11(3), SOCS2(2), SOCS3(1), SOCS4(2), SOCS5(3), SOS1(11), SOS2(7), SPRED1(3), SPRED2(1), SPRY2(1), SPRY3(4), STAM(3), STAM2(2), STAT1(2), STAT2(1), STAT3(2), STAT4(5), STAT5A(2), STAT6(2), TPO(10), TYK2(8) 38492876 365 141 349 111 118 104 25 67 51 0 0.487 1.000 1.000 288 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(3), ACVR2A(4), AMHR2(7), BMPR1A(3), BMPR1B(1), BMPR2(1), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL28(1), CCL3(2), CCL7(1), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CCR9(1), CD27(1), CD40(2), CD40LG(3), CNTFR(1), CRLF2(2), CSF1(2), CSF1R(3), CSF2RA(7), CSF2RB(6), CSF3R(7), CX3CR1(3), CXCL14(1), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EDAR(2), EGF(6), EGFR(7), EPOR(2), FAS(1), FASLG(1), FLT1(12), FLT3(7), FLT4(5), GDF5(3), GH1(2), GH2(4), GHR(3), HGF(10), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL17A(1), IL17RA(6), IL18R1(2), IL18RAP(4), IL19(1), IL1A(2), IL1B(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), INHBA(5), INHBB(1), INHBC(1), KDR(15), KIT(7), LEPR(15), LIFR(3), LTA(2), LTB(1), LTBR(1), MET(4), MPL(2), NGFR(1), OSMR(6), PDGFB(1), PDGFC(2), PDGFRA(7), PDGFRB(6), PF4(1), PLEKHO2(5), PRL(1), PRLR(6), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TPO(10), VEGFC(6), XCL1(1), XCR1(2) 46853372 402 140 399 156 95 145 22 79 61 0 0.973 1.000 1.000 289 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(2), CADM3(4), CD2(1), CD22(6), CD226(5), CD276(2), CD34(2), CD4(1), CD40(2), CD40LG(3), CD58(1), CD6(2), CD80(3), CD86(3), CD8A(2), CD8B(1), CD99(2), CDH1(3), CDH15(2), CDH2(10), CDH3(1), CDH4(6), CDH5(5), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(12), CNTN2(1), CNTNAP1(4), CNTNAP2(30), CTLA4(1), ESAM(4), F11R(1), GLG1(3), HLA-A(6), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(4), ITGA6(7), ITGA8(14), ITGA9(2), ITGAL(1), ITGAM(7), ITGAV(4), ITGB1(5), ITGB2(5), ITGB7(1), ITGB8(4), JAM2(2), L1CAM(1), MADCAM1(1), MAG(4), NCAM1(4), NCAM2(14), NEGR1(2), NEO1(8), NFASC(7), NLGN1(15), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(22), NRXN2(10), NRXN3(10), PDCD1(1), PTPRC(7), PTPRF(7), PTPRM(6), PVR(1), PVRL1(3), PVRL3(3), SDC2(2), SDC3(1), SELE(4), SELL(2), SELP(11), SELPLG(1), SIGLEC1(9), VCAM1(5), VCAN(23) 39075264 431 138 430 159 134 143 31 74 47 2 0.879 1.000 1.000 290 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRB1(1), CSNK1D(2), DRD1(1), DRD2(4), EGF(6), EGFR(7), GJA1(4), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAS(7), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), NRAS(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(6), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), PRKX(1), RAF1(1), SOS1(11), SOS2(7), TJP1(9), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(8), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB8(1) 35068163 354 138 351 98 85 121 29 67 52 0 0.0611 1.000 1.000 291 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ATF4(2), CACNA1C(18), CACNA1D(6), CACNA1F(10), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CDC42(1), CGA(2), EGFR(7), FSHB(2), GNA11(1), GNAS(7), HBEGF(1), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(3), JUN(3), KRAS(2), LHB(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K3(1), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(2), MMP2(3), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLD1(7), PLD2(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCD(2), PRKX(1), RAF1(1), SOS1(11), SOS2(7) 33804548 297 138 293 92 70 117 20 54 36 0 0.277 1.000 1.000 292 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(2), ACACB(9), AKT1(1), AKT3(3), ARAF(3), BRAF(8), CALM2(1), CALML6(1), CBL(3), CBLB(7), CRKL(1), EXOC7(1), FASN(2), FBP2(1), FLOT2(1), G6PC(3), G6PC2(3), GCK(5), GYS1(1), GYS2(4), HRAS(5), IKBKB(2), INPP5D(8), INSR(9), IRS1(6), IRS2(1), IRS4(3), KRAS(2), LIPE(1), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK2(1), NRAS(1), PCK1(3), PCK2(1), PDE3A(9), PDE3B(5), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PKLR(4), PPARGC1A(5), PPP1CA(1), PPP1R3A(16), PPP1R3C(2), PPP1R3D(2), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(7), PYGB(3), PYGL(3), PYGM(6), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SLC2A4(2), SOCS2(2), SOCS3(1), SOCS4(2), SORBS1(5), SOS1(11), SOS2(7), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5) 42393088 369 137 355 120 117 123 23 48 58 0 0.486 1.000 1.000 293 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CALML6(1), CDS1(2), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), FN3K(1), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPP5B(7), INPP5D(8), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), OCRL(8), PI4KA(8), PI4KB(1), PIK3C2A(6), PIK3C2B(7), PIK3C2G(8), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(4), PRKCA(5), PRKCG(9), PTEN(16), SYNJ1(4), SYNJ2(4) 33122627 329 135 313 79 103 108 15 49 54 0 0.00939 1.000 1.000 294 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(9), ACTN4(5), ARHGAP5(2), BCAR1(6), CD99(2), CDC42(1), CDH5(5), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNA1(2), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(3), GNAI3(1), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), ITK(2), JAM2(2), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(3), MMP9(6), MSN(4), MYL2(2), MYL9(1), NCF2(3), NCF4(1), NOX1(2), NOX3(6), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PRKCA(5), PRKCG(9), PTK2(6), PTPN11(3), PXN(3), RAC1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(6), RASSF5(1), RHOH(4), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCAM1(5), VCL(2) 32908753 343 135 330 96 109 119 20 51 44 0 0.103 1.000 1.000 295 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(8), CACNA1A(11), CRHR1(4), GNA11(1), GNA12(2), GNA13(1), GNAI1(3), GNAI3(1), GNAS(7), GNAZ(3), GRIA1(9), GRIA2(7), GRIA3(10), GRID2(15), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), IGF1(3), IGF1R(1), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(11), NOS3(2), NPR1(4), NPR2(4), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP2R1A(8), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), RAF1(1), RYR1(28) 29214472 321 134 319 89 77 111 27 52 54 0 0.0707 1.000 1.000 296 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(2), AKT1(1), AKT3(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(8), CDC42(1), CDKN2A(26), CSE1L(4), DOCK1(4), EPHB2(6), FYN(5), ILK(1), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), P4HB(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PIK3CA(29), PIK3CB(4), PKLR(4), PLCG1(3), PLCG2(4), PTEN(16), PTK2(6), RAF1(1), RALA(3), RHO(1), ROCK1(5), ROCK2(3), SHC1(2), SOS1(11), SOS2(7), TLN1(6), TLN2(14), VASP(2), WAS(3), ZYX(1) 32497462 302 132 285 80 99 82 11 51 58 1 0.126 1.000 1.000 297 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(10), ADCY8(18), ARAF(3), ATF4(2), BRAF(8), CACNA1C(18), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CREBBP(17), EP300(9), GRIA1(9), GRIA2(7), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP1CA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5) 26447306 285 131 281 92 61 110 28 46 40 0 0.443 1.000 1.000 298 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(10), ABCA10(10), ABCA12(7), ABCA13(33), ABCA2(9), ABCA3(4), ABCA4(12), ABCA5(5), ABCA6(7), ABCA7(4), ABCA8(6), ABCA9(12), ABCB1(18), ABCB10(5), ABCB11(6), ABCB4(8), ABCB5(14), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(6), ABCC12(15), ABCC2(6), ABCC3(2), ABCC4(1), ABCC5(7), ABCC6(1), ABCC8(6), ABCC9(10), ABCD1(3), ABCD2(12), ABCD4(1), ABCG1(1), ABCG2(3), ABCG4(4), ABCG5(2), ABCG8(7), CFTR(8), TAP1(3), TAP2(1) 31371140 292 129 290 93 80 89 16 66 39 2 0.304 1.000 1.000 299 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BMPR2(1), BUB1(4), CDKL2(2), CDS1(2), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MOS(4), NEK1(3), OCRL(8), PAK4(1), PIK3C2A(6), PIK3C2B(7), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(18), PIM2(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(4), PLK3(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKG1(6), RAF1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KB1(1), STK11(3), VRK1(1) 30000877 281 129 267 70 89 88 19 43 42 0 0.0623 1.000 1.000 300 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN4(5), ACVR1B(3), ACVR1C(4), BAIAP2(2), CDC42(1), CDH1(3), CREBBP(17), CSNK2A1(2), CTNNA1(2), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), EGFR(7), EP300(9), ERBB2(3), FARP2(7), FER(3), FGFR1(1), FYN(5), IGF1R(1), INSR(9), IQGAP1(8), LEF1(3), LMO7(7), MAP3K7(2), MAPK1(1), MAPK3(1), MET(4), MLLT4(4), NLK(2), PARD3(7), PTPN1(1), PTPRB(15), PTPRF(7), PTPRJ(4), PTPRM(6), PVRL1(3), PVRL3(3), PVRL4(6), RAC1(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(4), SNAI2(3), SORBS1(5), SSX2IP(2), TCF7(1), TCF7L2(1), TGFBR2(3), TJP1(9), VCL(2), WAS(3), WASF1(1), WASF3(1), WASL(2), YES1(1) 31739977 282 128 280 86 80 86 17 56 43 0 0.555 1.000 1.000 301 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADSL(1), ADSS(1), AK2(1), AK5(7), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), NPR1(4), NPR2(4), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(5), PKLR(4), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLRMT(2), PPAT(2), PRPS1(2), PRPS1L1(3), PRPS2(2), RRM1(1), RRM2(1) 34024956 281 128 281 89 74 95 16 50 46 0 0.411 1.000 1.000 302 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(3), BRAF(8), CD244(3), FAS(1), FASLG(1), FCER1G(1), FCGR3A(5), FYN(5), GZMB(1), HLA-A(6), HLA-B(1), HLA-C(1), HLA-G(2), HRAS(5), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), ITGAL(1), ITGB2(5), KIR2DL3(4), KIR3DL1(5), KIR3DL2(2), KLRC1(1), KLRC3(2), KLRD1(1), KRAS(2), LCK(3), LCP2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NCR1(6), NCR2(1), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NRAS(1), PAK1(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRF1(1), PRKCA(5), PRKCG(9), PTPN11(3), RAC1(1), RAF1(1), SH2D1A(2), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TYROBP(3), ULBP1(2), ULBP3(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5) 29854704 296 127 281 77 99 102 14 41 39 1 0.0432 1.000 1.000 303 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), AKAP1(2), AKAP11(7), AKAP12(4), AKAP2(4), AKAP3(8), AKAP4(6), AKAP5(1), AKAP6(15), AKAP7(2), AKAP8(5), AKAP9(11), ARHGEF1(2), CALM2(1), CHMP1B(1), GNA11(1), GNA12(2), GNA13(1), GNA14(3), GNAI3(1), GNAL(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(5), ITPR1(6), KCNJ3(11), KRAS(2), NRAS(1), PALM2(1), PDE1A(2), PDE1B(3), PDE1C(12), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PLCB3(4), PPP3CA(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKD3(2), SLC9A1(3), USP5(2) 31035628 292 126 290 67 81 97 20 50 44 0 0.00742 1.000 1.000 304 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(10), BDKRB1(3), BDKRB2(3), C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C3AR1(2), C4BPA(2), C5(1), C5AR1(3), C6(18), C7(12), C8A(6), C8B(4), C9(3), CD46(2), CD55(1), CFB(2), CFH(8), CFI(3), CPB2(3), CR1(7), CR2(11), F10(3), F11(3), F12(1), F13A1(5), F13B(12), F2R(2), F3(1), F5(18), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), KNG1(9), MASP1(9), MASP2(1), MBL2(4), PLAT(1), PLAUR(2), PLG(2), PROS1(5), SERPINA1(1), SERPINA5(3), SERPINC1(7), SERPIND1(2), SERPINF2(3), SERPING1(3), VWF(17) 24083078 272 126 272 79 66 100 21 48 37 0 0.350 1.000 1.000 305 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(4), CAPN11(2), CAPN2(2), CAPN3(8), CAPN5(2), CAPN6(7), CAPN7(1), CAPN9(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(4), FYN(5), ILK(1), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAPK10(1), MAPK12(1), MAPK4(2), MAPK6(4), MAPK7(1), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(4), PTK2(6), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(6), SEPP1(2), SHC1(2), SHC3(2), SORBS1(5), SOS1(11), TLN1(6), TNS1(5), VASP(2), VAV2(4), VAV3(1), VCL(2), ZYX(1) 35619810 270 124 269 93 75 95 20 45 34 1 0.680 1.000 1.000 306 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(2), ALG6(2), ALG8(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT5(2), C1GALT1C1(1), CHPF(2), CHST1(3), CHST11(2), CHST12(1), CHST2(5), CHST3(2), CHST4(2), CHST6(5), CHSY1(2), DDOST(1), EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(13), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL5(4), GANAB(5), GCNT1(3), GCNT3(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(3), NDST1(4), NDST2(2), NDST3(4), NDST4(14), OGT(2), RPN1(1), ST3GAL1(4), ST3GAL4(2), ST6GAL1(2), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(11), XYLT1(6) 29153233 239 123 237 80 62 100 15 34 28 0 0.484 1.000 1.000 307 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT3(3), BCL2L1(1), CDC42(1), CDKN2A(26), CREB1(1), CREB5(3), EBP(1), ERBB4(13), F2RL2(1), GAB1(3), GADD45A(1), GSK3A(3), IFI27(3), IGF1(3), INPPL1(4), IRS1(6), IRS2(1), IRS4(3), MET(4), MYC(1), NOLC1(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PPP1R13B(5), PREX1(14), PTEN(16), PTK2(6), PTPN1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SLC2A4(2), SOS1(11), SOS2(7), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1) 20439040 230 123 213 53 76 61 9 37 47 0 0.0401 1.000 1.000 308 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2B(8), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(1), DDX56(1), ENPP1(8), ENPP3(6), ENTPD7(2), EP400(9), ERCC3(1), G6PC(3), G6PC2(3), GANC(4), GBA(4), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), IFIH1(4), MGAM(5), MOV10L1(7), NUDT8(1), PGM1(1), PYGB(3), PYGL(3), PYGM(6), RAD54L(1), SETX(12), SI(46), SKIV2L2(2), SMARCA2(4), UGDH(2), UGP2(4), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UXS1(4) 32566251 272 120 272 76 65 101 23 49 34 0 0.262 1.000 1.000 309 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CREB1(1), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(17), CTNNB1(4), DCT(4), DVL1(2), DVL3(2), EDNRB(5), EP300(9), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), GNAI1(3), GNAI3(1), GNAS(7), HRAS(5), KIT(7), KRAS(2), LEF1(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MC1R(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), POMC(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), TCF7(1), TCF7L2(1), TYR(10), TYRP1(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 28796144 267 120 265 82 51 107 25 53 31 0 0.227 1.000 1.000 310 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(3), ACVR1C(4), ACVR2A(4), ACVRL1(3), AMHR2(7), BMP4(1), BMP5(8), BMPR1A(3), BMPR1B(1), BMPR2(1), CDKN2B(1), CHRD(6), COMP(1), CREBBP(17), CUL1(4), DCN(1), E2F5(2), EP300(9), GDF5(3), GDF6(2), ID2(1), ID4(1), IFNG(1), INHBA(5), INHBB(1), INHBC(1), LEFTY2(3), LTBP1(16), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(8), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), RBL1(5), RBL2(7), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SKP1(1), SMAD1(3), SMAD2(2), SMAD3(1), SMAD4(5), SMAD7(2), SMAD9(1), SMURF1(2), SP1(2), TFDP1(3), TGFB2(3), TGFBR2(3), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNF(1), ZFYVE16(3), ZFYVE9(6) 26188844 214 118 212 65 61 73 14 34 32 0 0.527 1.000 1.000 311 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(7), AKT1(1), AKT3(3), ARAF(3), AREG(3), BRAF(8), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CBL(3), CBLB(7), CDKN1A(2), CRKL(1), EGF(6), EGFR(7), ERBB2(3), ERBB3(4), ERBB4(13), EREG(1), GAB1(3), HBEGF(1), HRAS(5), JUN(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(2), NRAS(1), NRG1(3), NRG2(2), NRG3(8), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PRKCA(5), PRKCG(9), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), STAT5A(2), TGFA(1) 27210270 266 116 250 70 90 94 11 39 32 0 0.0834 1.000 1.000 312 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT3(3), CARD11(5), CBL(3), CBLB(7), CD3D(1), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHUK(2), CTLA4(1), FOS(2), FYN(5), GRAP2(1), HRAS(5), ICOS(2), IFNG(1), IKBKB(2), IL10(2), IL4(2), ITK(2), JUN(3), KRAS(2), LCK(3), LCP2(2), MALT1(1), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PDCD1(1), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKCQ(4), PTPRC(7), RASGRP1(1), SOS1(11), SOS2(7), TEC(4), TNF(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5) 26889196 242 114 227 53 83 73 15 39 32 0 0.0135 1.000 1.000 313 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT3(3), BTK(7), FCER1A(3), FCER1G(1), FYN(5), GAB2(1), HRAS(5), IL3(1), IL4(2), INPP5D(8), KRAS(2), LCP2(2), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(4), NRAS(1), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(4), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(11), SOS2(7), SYK(2), TNF(1), VAV1(7), VAV2(4), VAV3(1) 19091815 210 112 196 48 66 70 17 26 31 0 0.0240 1.000 1.000 314 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT3(3), BLNK(1), BTK(7), CARD11(5), CD19(2), CD22(6), CD79A(1), CD81(2), CHUK(2), CR2(11), FCGR2B(3), FOS(2), HRAS(5), IKBKB(2), INPP5D(8), JUN(3), KRAS(2), LILRB3(2), LYN(2), MALT1(1), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), RAC1(1), RASGRP3(8), SYK(2), VAV1(7), VAV2(4), VAV3(1) 19725860 200 111 185 46 66 59 12 30 33 0 0.0313 1.000 1.000 315 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPP5B(7), INPP5E(2), INPPL1(4), IPMK(2), ITPK1(3), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PI4KA(8), PI4KB(1), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(4), PTEN(16), SYNJ1(4), SYNJ2(4) 19697222 211 110 196 51 68 61 7 37 38 0 0.0441 1.000 1.000 316 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(3), CALM2(1), CHRNA1(4), FLT1(12), FLT4(5), KDR(15), NOS3(2), PDE2A(4), PDE3A(9), PDE3B(5), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(116), SLC7A1(4), SYT1(4) 10823358 209 109 207 58 46 77 17 36 33 0 0.172 1.000 1.000 317 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT3(3), BCR(2), BTK(7), CD19(2), CDKN2A(26), FLOT2(1), GAB1(3), ITPR1(6), ITPR2(14), ITPR3(3), LYN(2), NR0B2(1), PDK1(1), PHF11(2), PIK3CA(29), PITX2(3), PLCG2(4), PPP1R13B(5), PREX1(14), PTEN(16), PTPRC(7), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SYK(2), TEC(4), VAV1(7) 14690086 175 108 157 39 63 38 7 25 42 0 0.0404 1.000 1.000 318 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT3(3), CASP8(2), CCL3(2), CD14(2), CD40(2), CD80(3), CD86(3), CHUK(2), FADD(1), FOS(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(2), IKBKE(3), IL12A(1), IL12B(3), IL1B(1), IL6(1), IRAK1(4), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), SPP1(1), STAT1(2), TBK1(3), TLR1(2), TLR2(3), TLR3(2), TLR4(10), TLR5(2), TLR7(3), TLR8(4), TLR9(2), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(5) 23722982 205 107 190 62 78 55 11 34 27 0 0.373 1.000 1.000 319 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(7), CD14(2), CD19(2), CD1A(4), CD1B(5), CD1C(5), CD1D(4), CD1E(4), CD2(1), CD22(6), CD33(3), CD34(2), CD36(1), CD37(3), CD38(2), CD3D(1), CD4(1), CD44(5), CD5(2), CD55(1), CD7(1), CD8A(2), CD8B(1), CD9(1), CR1(7), CR2(11), CSF1(2), CSF1R(3), CSF2RA(7), CSF3R(7), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(7), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL11RA(1), IL1A(2), IL1B(1), IL1R1(1), IL1R2(3), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL7(1), IL7R(8), IL9R(6), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGAM(7), ITGB3(4), KIT(7), MME(9), MS4A1(2), TFRC(2), TNF(1), TPO(10) 21663912 227 107 226 75 51 76 10 55 35 0 0.684 1.000 1.000 320 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT3(3), CASP9(3), CDC42(1), HRAS(5), KDR(15), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NOS3(2), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PRKCA(5), PRKCG(9), PTGS2(1), PTK2(6), PXN(3), RAC1(1), RAF1(1), SH2D2A(2), SHC2(5), SPHK2(1) 19054474 204 104 189 53 73 68 10 23 30 0 0.0648 1.000 1.000 321 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(5), AGTR2(3), ATP8A1(10), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(5), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GRPR(3), LHCGR(9), MC1R(1), MC2R(2), MC3R(2), MC4R(2), MC5R(3), NMBR(3), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(3), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(6), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(5) 13793598 172 103 172 65 28 71 11 34 28 0 0.478 1.000 1.000 322 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), CD22(6), CD81(2), CR2(11), DAG1(2), FLOT2(1), GSK3A(3), INPP5D(8), ITPR1(6), ITPR2(14), ITPR3(3), LYN(2), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(3), NFATC2(5), NR0B2(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(4), PPP1R13B(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(7), RAF1(1), SHC1(2), SOS1(11), SOS2(7), SYK(2), VAV1(7) 19644866 180 102 166 53 63 51 8 29 29 0 0.318 1.000 1.000 323 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT3(3), BRD4(3), CAP1(1), CBL(3), CDC42(1), CDKN2A(26), F2RL2(1), FLOT2(1), GSK3A(3), INPPL1(4), IRS1(6), IRS2(1), IRS4(3), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PTEN(16), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(2), SLC2A4(2), SORBS1(5), SOS1(11), SOS2(7), YWHAB(1), YWHAQ(1) 15695994 168 102 151 35 63 34 6 26 39 0 0.0374 1.000 1.000 324 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(1), AKT3(3), ARHGAP1(1), ARHGAP4(2), ARHGEF11(7), BTK(7), CDC42(1), CFL1(2), CFL2(1), GDI1(2), GDI2(2), INPPL1(4), ITPR1(6), ITPR2(14), ITPR3(3), MYLK(8), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3CG(18), PIK3R1(2), PITX2(3), PPP1R13B(5), PTEN(16), RACGAP1(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1), WASL(2) 18670087 173 101 158 43 50 55 8 28 32 0 0.0945 1.000 1.000 325 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(2), CCKBR(2), CCR2(1), CCR3(1), CCR5(1), CELSR1(11), CELSR2(8), CELSR3(6), CHRM2(8), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(5), F2R(2), FSHR(15), GHRHR(4), GPR116(5), GPR132(1), GPR133(3), GPR135(2), GPR143(2), GPR17(4), GPR18(2), GPR55(1), GPR56(1), GPR61(2), GRM1(13), GRPR(3), HRH4(4), LGR6(1), LPHN2(7), LPHN3(17), LTB4R2(1), NTSR1(4), OR2M4(4), P2RY13(1), PTGFR(5), SMO(1), SSTR2(2), TAAR5(5), TSHR(5), VN1R1(4) 17564572 179 99 179 63 51 63 14 36 15 0 0.329 1.000 1.000 326 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(3), CDC40(2), CLK2(2), CLK3(1), CLK4(2), COL2A1(12), CPSF1(4), CPSF2(3), CPSF3(2), CPSF4(2), CSTF2(2), CSTF2T(3), CSTF3(1), DDX1(6), DHX15(3), DHX16(2), DHX38(2), DHX8(2), DHX9(2), DICER1(13), FUS(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF3(1), PRPF4(2), PRPF4B(6), PRPF8(7), PSKH1(1), PTBP2(3), RBM17(1), RBM5(2), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(1), SNRPA(2), SNRPA1(1), SNRPB(3), SNRPD1(2), SNRPD2(1), SNRPD3(1), SNRPF(1), SNRPN(5), SPOP(1), SRPK1(3), SRPK2(1), SRRM1(4), SUPT5H(2), U2AF2(1), XRN2(3) 27886092 150 98 150 37 39 57 8 27 19 0 0.233 1.000 1.000 327 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(5), CALM2(1), CAMK2B(1), CAMK4(3), CDKN1A(2), CNR1(5), CREBBP(17), CSNK2A1(2), CTLA4(1), EGR2(6), EGR3(2), EP300(9), FCER1A(3), FCGR3A(5), FKBP1B(1), FOS(2), FOSL1(1), GATA3(6), GSK3A(3), HRAS(5), ICOS(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL1B(1), IL3(1), IL4(2), IL6(1), ITK(2), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(3), MYF5(7), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NPPB(1), NUP214(5), OPRD1(2), P2RX7(2), PAK1(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(7), RELA(3), SFN(2), SLA(2), SP1(2), SP3(1), TNF(1), TRPV6(3), VAV1(7), VAV2(4), VAV3(1), XPO5(2) 24071734 194 96 192 56 52 73 15 31 23 0 0.309 1.000 1.000 328 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(9), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ADIPOR2(4), AKT1(1), AKT3(3), CAMKK2(1), CD36(1), CHUK(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), G6PC(3), G6PC2(3), IKBKB(2), IRS1(6), IRS2(1), IRS4(3), JAK1(2), JAK2(4), JAK3(7), LEPR(15), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NPY(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(5), PRKAA2(5), PRKAB2(1), PRKAG2(4), PRKAG3(3), PRKCQ(4), PTPN11(3), RELA(3), RXRA(2), RXRG(7), SLC2A1(1), SLC2A4(2), SOCS3(1), STAT3(2), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(8) 21924435 167 95 166 48 44 59 10 24 30 0 0.192 1.000 1.000 329 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA2(1), CD36(1), CITED2(1), CPT1B(3), CREBBP(17), EHHADH(1), EP300(9), FABP1(1), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), ME1(2), MRPL11(1), MYC(1), NCOA1(6), NCOR1(7), NCOR2(7), NR0B2(1), NR1H3(2), NRIP1(3), PIK3CA(29), PIK3R1(2), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PTGS2(1), RB1(12), RELA(3), RXRA(2), SP1(2), STAT5A(2), TNF(1) 16730642 146 94 131 45 49 40 5 27 25 0 0.599 1.000 1.000 330 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2B(8), ENPP1(8), ENPP3(6), G6PC(3), GANAB(5), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), MGAM(5), PGM1(1), PYGB(3), PYGL(3), PYGM(6), SI(46), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2B15(3), UGT2B4(8), UXS1(4) 15136397 166 94 166 37 35 68 9 32 22 0 0.0266 1.000 1.000 331 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(9), ASH2L(4), CARM1(1), CTCFL(2), DOT1L(5), EED(2), EHMT1(5), EHMT2(1), EZH1(4), EZH2(4), FBXO11(6), HCFC1(1), HSF4(1), JMJD6(1), KDM6A(7), MEN1(3), NSD1(10), OGT(2), PPP1CA(1), PRDM2(6), PRDM7(1), PRDM9(15), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(5), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(2), SUV39H2(2), SUV420H1(6), SUZ12(4), WHSC1(1), WHSC1L1(16) 31533699 162 93 161 37 52 47 5 28 30 0 0.135 1.000 1.000 332 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT3(3), BRAF(8), CAB39(1), DDIT4(2), EIF4B(5), FIGF(2), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(18), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), STK11(3), TSC1(5), TSC2(5), ULK1(4), ULK2(5), VEGFC(6) 14063036 148 93 134 32 53 41 11 18 25 0 0.0535 1.000 1.000 333 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(3), BRAF(8), CHUK(2), CREB1(1), DAXX(3), FOS(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP3K9(3), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(4), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MEF2A(2), MEF2C(4), MEF2D(3), MKNK2(1), MYC(1), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(1), RELA(3), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB2(3), TRADD(1) 25334500 159 93 156 64 53 56 8 21 21 0 0.947 1.000 1.000 334 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRKL(1), DOCK1(4), FOS(2), GAB1(3), HGF(10), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MET(4), PAK1(2), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), PTPN11(3), PXN(3), RAF1(1), RAP1A(1), RAP1B(1), RASA1(8), SOS1(11), STAT3(2) 11740469 139 93 123 37 54 26 4 25 30 0 0.451 1.000 1.000 335 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(8), CPEB1(1), EGFR(7), ERBB2(3), ERBB4(13), ETS1(2), ETV6(4), FMN2(26), KRAS(2), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(16), NOTCH2(9), NOTCH3(7), NOTCH4(4), PIWIL1(9), PIWIL2(4), PIWIL3(4), RAF1(1), SOS1(11), SOS2(7), SPIRE1(2), SPIRE2(5) 13750291 149 91 148 42 36 49 7 28 28 1 0.362 1.000 1.000 336 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PIK3C2A(6), PIK3C2B(7), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(18), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(4) 11951420 141 91 128 36 48 44 8 20 21 0 0.143 1.000 1.000 337 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1G(3), CAMK4(3), CREBBP(17), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(2), HRAS(5), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(31), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NKX2-5(1), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RAF1(1), RPS6KB1(1), SYT1(4) 13373979 163 91 149 45 57 56 9 24 17 0 0.267 1.000 1.000 338 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(9), AR(5), BRAF(8), CCL16(1), DAG1(2), EGFR(7), GNA11(1), GNAI1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(29), PIK3CD(4), PIK3R1(2), PITX2(3), PTX3(2), RAF1(1) 14155785 131 91 116 26 47 40 6 23 15 0 0.0128 1.000 1.000 339 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AGPAT6(1), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT1(1), DGAT2(3), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), GK(4), GK2(6), GLA(2), GPAM(3), LCT(19), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(3), MGLL(1), PNLIP(11), PNLIPRP1(3), PNPLA3(1), PPAP2B(2) 15560990 132 88 132 47 33 57 3 24 15 0 0.639 1.000 1.000 340 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), DAG1(2), EPHB2(6), ITPKA(1), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), PI3(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(4), PPP1R13B(5), RAF1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), SYK(2), VAV1(7) 13969273 130 86 117 36 48 35 7 23 17 0 0.291 1.000 1.000 341 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(1), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ANGPTL4(1), APOA2(1), APOA5(3), APOC3(2), AQP7(1), CD36(1), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP27A1(1), CYP4A22(2), CYP7A1(5), CYP8B1(1), DBI(2), EHHADH(1), FABP1(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(6), HMGCS2(3), ILK(1), LPL(3), ME1(2), MMP1(3), NR1H3(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(3), PPARA(1), PPARD(2), RXRA(2), RXRG(7), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A4(2), SLC27A5(4), SLC27A6(5), SORBS1(5), UBC(1), UCP1(2) 17311035 132 85 132 52 25 48 10 28 21 0 0.884 1.000 1.000 342 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ALDH4A1(3), ALDH5A1(1), CAD(10), CPS1(28), EARS2(3), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GFPT2(3), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSR(4), GSS(2), NADSYN1(7), NAGK(2), PPAT(2) 10490270 126 84 125 29 29 56 6 23 12 0 0.0553 1.000 1.000 343 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT3(3), BRAF(8), DAG1(2), DRD2(4), EGFR(7), EPHB2(6), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PI3(1), PIK3CB(4), PITX2(3), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(11), SOS2(7), STAT3(2) 15553925 134 84 132 36 34 48 6 24 22 0 0.182 1.000 1.000 344 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(7), CALM2(1), FCER1A(3), FCER1G(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), PAK2(1), PIK3CA(29), PIK3R1(2), PLA2G4A(7), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(2), SOS1(11), SYK(2), SYT1(4), VAV1(7) 11363498 130 83 115 32 53 39 8 16 14 0 0.218 1.000 1.000 345 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(8), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1D(2), CSNK1G1(3), CSNK1G2(1), DHH(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(9), HHIP(3), IHH(1), LRP2(40), PRKACB(3), PRKACG(1), PRKX(1), PTCH1(5), PTCH2(5), SHH(2), SMO(1), STK36(5), SUFU(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1), ZIC2(1) 15992445 141 83 140 57 33 50 16 23 19 0 0.878 1.000 1.000 346 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(13), COL4A3(10), COL4A4(11), COL4A5(3), COL4A6(8), F10(3), F11(3), F12(1), F2R(2), F5(18), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), PROS1(5), SERPINC1(7), SERPING1(3) 11776850 132 83 132 32 29 57 7 20 19 0 0.327 1.000 1.000 347 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(4), ARHGDIB(2), BAG4(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), CRADD(1), DAXX(3), DFFB(2), FADD(1), GSN(2), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK8(2), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(12), PSEN1(3), PSEN2(3), PTK2(6), RASA1(8), RB1(12), RELA(3), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 18474435 116 82 115 34 28 31 4 19 34 0 0.521 1.000 1.000 348 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3A1(2), ALDH3B2(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(7), CYP2C8(2), CYP2C9(3), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), MGST1(2), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2) 14910265 124 82 124 39 28 44 11 30 11 0 0.530 1.000 1.000 349 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), BRAF(8), CREB1(1), CREB5(3), CREBBP(17), CRKL(1), DAG1(2), EGR1(2), EGR2(6), EGR3(2), FRS2(4), JUN(3), MAP1B(4), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), NTRK1(4), OPN1LW(3), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), PTPN11(3), RPS6KA3(1), SHC1(2), TH(2) 13630389 126 81 112 41 49 42 7 18 10 0 0.587 1.000 1.000 350 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(2), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CARM1(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), DDC(5), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), INMT(3), KMO(1), KYNU(3), LCMT1(2), LCMT2(1), LNX1(2), METTL2B(1), METTL6(2), NFX1(2), OGDH(3), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), TDO2(2), TPH1(2), TPH2(6), WARS(4), WARS2(2), WBSCR22(3) 16031150 119 80 119 44 26 39 5 31 18 0 0.787 1.000 1.000 351 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(17), CTBP1(2), DLL1(1), DLL3(1), DLL4(1), DTX2(3), DTX3(2), DTX3L(3), DTX4(2), DVL1(2), DVL3(2), EP300(9), HDAC1(2), JAG1(2), JAG2(2), LFNG(1), MAML1(3), MAML2(7), MFNG(1), NCOR2(7), NCSTN(4), NOTCH1(16), NOTCH2(9), NOTCH3(7), NOTCH4(4), PSEN1(3), PSEN2(3), PSENEN(1), SNW1(2) 18305930 119 80 118 44 18 38 11 27 25 0 0.871 1.000 1.000 352 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), CCND1(1), CCND2(3), CCND3(1), CTNNB1(4), DVL1(2), DVL3(2), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LDLR(4), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PPP2R5C(6), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), RAC1(1), SFRP4(4), TCF7(1), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1) 15854150 126 80 125 39 38 51 8 18 11 0 0.341 1.000 1.000 353 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), G6PC2(3), GAPDH(2), GAPDHS(1), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGAM4(1), PGK1(2), PGK2(4), PGM1(1), PKLR(4), TPI1(3) 15386973 108 79 108 49 28 40 8 17 15 0 0.957 1.000 1.000 354 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(4), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(8), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB8(1), WAS(3), WASL(2), YWHAQ(1) 13917671 112 79 111 27 35 31 11 14 21 0 0.121 1.000 1.000 355 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(4), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(8), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB8(1), WAS(3), WASL(2), YWHAQ(1) 13917671 112 79 111 27 35 31 11 14 21 0 0.121 1.000 1.000 356 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(27), B3GALT4(1), CDR1(4), DGKI(13), IL6ST(1), MRPL19(1), PIGK(1), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL34(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(2), RPL7(1), RPL7A(1), RPL8(2), RPLP0(2), RPS11(1), RPS12(1), RPS18(1), RPS19(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS8(2), SLC36A2(2), TBC1D10C(3), TSPAN9(1), UBB(2), UBC(1) 13868005 102 79 102 38 28 28 7 26 13 0 0.836 1.000 1.000 357 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD3D(1), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(6), FBXW7(10), GRAP2(1), ITK(2), ITPKA(1), ITPKB(6), LCK(3), LCP2(2), MAPK1(1), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PLCG1(3), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), SOS1(11), SOS2(7), VAV1(7), ZAP70(5) 14847334 122 79 119 37 31 38 12 23 18 0 0.530 1.000 1.000 358 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(3), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(2), COX4I1(1), COX4I2(1), COX6B1(2), COX6C(1), COX7B2(3), CYC1(5), NDUFA10(3), NDUFA13(1), NDUFA7(1), NDUFA9(1), NDUFAB1(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(2), NDUFB9(1), NDUFS1(4), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(2), SDHB(2), UQCRB(1), UQCRC2(1), UQCRFS1(2) 14780080 107 78 107 29 23 28 13 26 17 0 0.319 1.000 1.000 359 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(10), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(8), DPYS(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), NME4(1), NME7(3), NT5C1A(2), NT5C1B(1), NT5C2(3), NT5E(2), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2), PRIM1(3), PRIM2(4), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), TXNRD1(2), TXNRD2(3), UMPS(2), UPP1(3), UPP2(1), UPRT(1) 21538795 122 78 121 55 35 41 6 15 25 0 0.989 1.000 1.000 360 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(6), AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(14), FLNC(16), FSCN2(1), FSCN3(2), GDI1(2), GDI2(2), MYH2(31), MYLK(8), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(7), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASF1(1), WASL(2) 12714411 120 77 120 41 29 52 7 17 15 0 0.567 1.000 1.000 361 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(1), DAG1(2), DGKA(3), ETFA(3), GCA(2), ITGA9(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(9), PDE3B(5), PI3(1), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), RIPK3(1), SGCB(3), VASP(2) 12969096 114 77 100 31 44 36 4 16 14 0 0.191 1.000 1.000 362 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(2), ADCY8(18), CACNA1A(11), CACNA1B(10), GNAS(7), GNAT3(1), GNB1(1), GNB3(2), GRM4(3), ITPR3(3), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(3), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(3), TAS1R3(3), TAS2R1(4), TAS2R10(3), TAS2R16(4), TAS2R3(2), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R40(3), TAS2R41(5), TAS2R42(2), TAS2R5(1), TAS2R60(8), TAS2R7(1), TAS2R8(1), TAS2R9(3), TRPM5(1) 15086884 129 76 129 49 32 42 7 34 14 0 0.740 1.000 1.000 363 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F12(1), F13B(12), F5(18), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), LPA(15), PLAT(1), PLG(2), SERPINB2(4), SERPINF2(3), VWF(17) 9325627 109 75 109 25 31 40 8 17 13 0 0.128 1.000 1.000 364 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), CEL(1), DGAT1(1), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), GK(4), GLA(2), LCT(19), LIPC(2), LIPF(1), LIPG(3), LPL(3), PNLIP(11), PNLIPRP1(3), PPAP2B(2) 12775167 103 75 103 38 25 44 3 18 13 0 0.698 1.000 1.000 365 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(8), CARS2(1), DARS(1), DARS2(5), EARS2(3), EPRS(12), FARS2(2), FARSA(5), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), NARS2(2), PARS2(4), RARS(4), RARS2(2), SARS(3), SARS2(3), TARS(3), TARS2(4), VARS(5), VARS2(2), WARS(4), WARS2(2), YARS(1), YARS2(2) 14365230 107 75 107 25 40 32 5 16 14 0 0.105 1.000 1.000 366 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(3), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(7), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JAM2(2), JUN(3), LYN(2), MAP2K4(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(4), PTPN11(3), PTPRZ1(9), RAC1(1), RELA(3), TJP1(9) 18621548 116 75 114 30 30 31 7 23 25 0 0.231 1.000 1.000 367 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(28), DAO(2), GATM(1), GLUD1(4), GOT2(3), NOS1(11), NOS3(2), OAT(1), ODC1(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(4), PYCR1(1), RARS(4), SMS(2) 11693515 108 74 107 27 21 43 3 22 19 0 0.0951 1.000 1.000 368 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT3(1), AGPAT4(1), AGPAT6(1), CDS1(2), CHAT(9), CHKA(4), CHPT1(1), CRLS1(1), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), ESCO1(2), ESCO2(2), ETNK1(3), GNPAT(2), GPAM(3), GPD1(2), GPD1L(1), GPD2(2), LYPLA1(3), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PNPLA3(1), PPAP2B(2), PTDSS1(4), SH3GLB1(1) 17375860 126 73 126 45 33 50 9 16 18 0 0.738 1.000 1.000 369 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A1L(12), GTF2B(2), GTF2E1(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(5), STON1(5), TAF1(14), TAF1L(20), TAF2(10), TAF4(3), TAF4B(4), TAF5(1), TAF5L(2), TAF6L(2), TAF7L(2), TAF9(2), TBPL2(1) 9561342 96 73 96 24 26 34 11 14 11 0 0.346 1.000 1.000 370 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(9), CAV3(1), DAG1(2), DLG4(1), EPHB2(6), GNAI1(3), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(28) 12203509 99 73 98 27 22 37 6 20 14 0 0.166 1.000 1.000 371 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT3(1), AGPAT4(1), AGPS(1), CDS1(2), CHAT(9), CHKA(4), CPT1B(3), DGKA(3), DGKB(6), DGKD(7), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), ETNK1(3), GNPAT(2), GPD1(2), GPD2(2), LGALS13(1), LYPLA1(3), PAFAH1B1(1), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(4), PPAP2B(2) 13242836 103 72 103 35 29 39 9 13 13 0 0.551 1.000 1.000 372 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(11), ACAT1(2), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), NSD1(10), OGDH(3), OGDHL(6), PIPOX(1), PLOD1(4), PLOD2(5), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), RDH14(1), SETD1A(8), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(2), SUV39H2(2), TMLHE(1) 15332602 107 72 107 42 20 35 7 23 22 0 0.881 1.000 1.000 373 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ACMSD(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(7), CYP2C8(2), CYP2C9(3), CYP2D6(2), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), DDC(5), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), KMO(1), KYNU(3), SDS(2), TDO2(2), TPH1(2), WARS(4), WARS2(2) 14600619 109 72 109 48 35 30 5 27 12 0 0.950 1.000 1.000 374 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), CARM1(1), DBH(2), DCT(4), DDC(5), ECH1(1), ESCO1(2), ESCO2(2), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PNMT(2), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SH3GLB1(1), TAT(1), TH(2), TPO(10), TYR(10), TYRP1(2), WBSCR22(3) 15738617 114 71 114 34 26 46 4 19 19 0 0.330 1.000 1.000 375 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(5), PFKP(2), PGK1(2), PGM1(1), PKLR(4), TPI1(3) 12914807 92 69 92 36 24 37 5 15 11 0 0.774 1.000 1.000 376 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(5), PFKP(2), PGK1(2), PGM1(1), PKLR(4), TPI1(3) 12914807 92 69 92 36 24 37 5 15 11 0 0.774 1.000 1.000 377 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(4), ACY3(2), ADSL(1), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(10), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), NARS2(2), PC(2), PDHA1(3), PDHA2(8) 10035740 89 69 89 31 24 30 5 18 12 0 0.649 1.000 1.000 378 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), ELAVL1(1), FLT1(12), FLT4(5), HIF1A(1), HRAS(5), KDR(15), NOS3(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), SHC1(2), VHL(1) 8990925 102 69 88 26 44 27 3 14 14 0 0.208 1.000 1.000 379 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(1), FYN(5), GSN(2), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PIK3CA(29), PIK3R1(2), PTK2(6), PXN(3), RAF1(1), ROCK1(5), SHC1(2), TLN1(6) 9907655 92 68 78 18 40 21 5 16 10 0 0.0723 1.000 1.000 380 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CXCR4(5), GNAI1(3), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(8), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), RAF1(1), RELA(3) 7359297 86 67 72 21 36 22 5 17 6 0 0.183 1.000 1.000 381 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(1), CDK5R1(1), CFL1(2), CHN1(2), MAP3K1(3), MYL2(2), MYLK(8), NCF2(3), PAK1(2), PDGFRA(7), PIK3CA(29), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(7), WASF1(1) 9281494 94 67 81 23 43 25 3 16 7 0 0.194 1.000 1.000 382 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT3(3), GSK3A(3), IL4R(2), IRS1(6), IRS2(1), JAK1(2), JAK3(7), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(11), SOS2(7), STAT6(2) 9665063 94 67 81 27 36 24 2 20 12 0 0.385 1.000 1.000 383 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRA(2), BLVRB(1), COX10(2), CP(2), CPOX(2), EARS2(3), EPRS(12), FECH(2), FTH1(2), FTMT(7), GUSB(2), HCCS(1), MMAB(1), PPOX(1), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UROD(1), UROS(1) 10906565 94 66 94 23 24 35 9 17 9 0 0.208 1.000 1.000 384 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(3), EGF(6), EGFR(7), ETS1(2), FOS(2), HOXA7(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), RAF1(1), RELA(3), SP1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1) 13005875 92 66 89 27 28 35 6 13 10 0 0.368 1.000 1.000 385 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(11), GABBR1(5), GPRC5A(1), GPRC5C(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM7(10), GRM8(14) 5532457 90 65 90 36 18 36 14 14 8 0 0.722 1.000 1.000 386 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(9), CCND1(1), CD14(2), CTNNB1(4), DVL1(2), FZD1(1), GJA1(4), GNAI1(3), IRAK1(4), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3), TLR4(10), TOLLIP(1), WNT1(1) 8114514 87 65 74 19 38 14 10 14 11 0 0.183 1.000 1.000 387 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(7), CALM2(1), CD79A(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYK(2), SYT1(4), VAV1(7) 10091050 93 64 91 21 29 33 8 11 12 0 0.144 1.000 1.000 388 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GAPDHS(1), GCK(5), GOT2(3), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6B(1), LDHB(3), LDHC(3), MDH1(1), MDH2(1), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PDHX(1), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGK1(2), PGK2(4), PKLR(4), TPI1(3) 11216771 89 64 89 42 23 33 5 16 12 0 0.951 1.000 1.000 389 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(1), ARSE(2), B4GALT6(2), CERK(6), DEGS1(1), ENPP7(4), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(19), NEU1(3), NEU2(2), NEU4(2), PPAP2B(2), SGMS1(3), SGMS2(1), SGPP1(2), SMPD1(4), SMPD2(1), SMPD3(3), SMPD4(8), SPHK2(1), SPTLC1(1), SPTLC2(3), UGCG(1), UGT8(6) 9449717 89 64 89 26 17 31 7 22 12 0 0.277 1.000 1.000 390 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(2), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(3) 6774899 90 64 90 37 20 36 7 18 9 0 0.483 1.000 1.000 391 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(5), ATF2(3), CALM2(1), EGFR(7), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(2), MEF2C(4), MEF2D(3), PAK1(2), PRKCA(5), PTK2(6), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 8876494 77 63 74 21 22 27 5 17 6 0 0.389 1.000 1.000 392 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(5), CALM2(1), CAMK1G(3), HDAC5(1), IGF1(3), IGF1R(1), INSR(9), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(4), MEF2D(3), MYOD1(1), NFATC1(3), NFATC2(5), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(4) 9194816 91 63 78 25 41 25 3 13 9 0 0.220 1.000 1.000 393 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(2), B4GALT1(1), G6PC(3), G6PC2(3), GALK2(1), GALT(1), GANC(4), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(19), MGAM(5), PFKL(2), PFKM(5), PFKP(2), PGM1(1), RDH11(1), RDH12(2), RDH13(1), RDH14(1), UGP2(4) 10247970 78 63 78 29 20 25 4 16 13 0 0.643 1.000 1.000 394 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(9), BCAR1(6), BCR(2), CAPN1(2), CAPNS2(1), CRKL(1), FYN(5), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(5), PTK2(6), PXN(3), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(11), TLN1(6), VCL(2), ZYX(1) 12459260 98 63 96 29 29 31 5 20 13 0 0.435 1.000 1.000 395 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CDK5(1), FYN(5), GNA11(1), GNAI1(3), GNB1(1), HRAS(5), JAK2(4), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(4), MYLK(8), PLCG1(3), PRKCA(5), RAF1(1), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2), SYT1(4) 11027890 80 62 79 21 18 27 10 15 10 0 0.318 1.000 1.000 396 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(2), CD4(1), CD8A(2), CD8B(1), CIITA(3), CREB1(1), CTSS(2), HLA-A(6), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), HSP90AA1(2), HSP90AB1(3), HSPA5(4), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), KIR2DL3(4), KIR3DL1(5), KIR3DL2(2), KIR3DL3(1), KLRC1(1), KLRC3(2), KLRD1(1), LTA(2), NFYA(1), NFYB(1), PDIA3(1), PSME2(1), TAP1(3), TAP2(1), TAPBP(2) 12292651 88 62 87 35 27 22 6 14 18 1 0.819 1.000 1.000 397 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(6), ADCY3(7), ADCY9(3), ARF1(1), ARF5(4), ATP6V0A1(3), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(7), PDIA4(4), PLCG1(3), PLCG2(4), PRKCA(5), SEC61A1(2), SEC61A2(1), SEC61G(2), TRIM23(3) 9798214 82 62 82 22 22 27 7 17 9 0 0.281 1.000 1.000 398 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAX(1), BCL2A1(2), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CD40(2), CD40LG(3), CRADD(1), DAXX(3), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(9), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(3), TRAF6(5) 11604373 79 61 78 31 24 16 5 17 17 0 0.928 1.000 1.000 399 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(1), CCND1(1), CREBBP(17), EP300(9), ERCC3(1), ESR1(6), GRIP1(6), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MEF2C(4), NCOR2(7), NR0B1(4), NRIP1(3), PELP1(1), POLR2A(2) 12164786 87 61 86 28 20 33 4 20 10 0 0.604 1.000 1.000 400 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(2), AOC3(3), CARM1(1), CNDP1(3), DDC(5), FTCD(3), HAL(2), HARS(2), HARS2(2), HDC(6), HNMT(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), PRPS1(2), PRPS2(2), UROC1(3), WBSCR22(3) 10476733 79 61 79 29 13 36 5 13 12 0 0.602 1.000 1.000 401 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(13), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL5(4), GCNT1(3), GCNT3(2), OGT(2), ST3GAL1(4), ST6GALNAC1(3), WBSCR17(11) 8546433 77 61 75 24 16 32 7 9 13 0 0.532 1.000 1.000 402 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(3), B3GALT2(3), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT2(1), FUT3(3), FUT5(5), FUT6(2), FUT9(5), GBGT1(2), GCNT2(2), PIGB(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGX(1), PIGZ(2), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3), UGCG(1) 12869860 84 61 84 34 22 31 9 11 11 0 0.748 1.000 1.000 403 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), NOS1(11), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), SYT1(4) 6750568 85 61 84 30 21 30 7 13 14 0 0.620 1.000 1.000 404 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(5), ESR1(6), ESR2(2), HNF4A(2), NR0B1(4), NR1D2(1), NR1H2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(3), NR2E1(4), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(3), NR5A2(5), PGR(4), PPARA(1), PPARD(2), RARA(1), RARB(3), RARG(1), ROR1(3), RORC(2), RXRA(2), RXRG(7), THRA(1), THRB(2), VDR(4) 11103406 82 61 82 31 20 33 2 14 13 0 0.705 1.000 1.000 405 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(10), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(8), DPYS(6), DTYMK(1), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLRMT(2), RRM1(1), RRM2(1), TXNRD1(2), UMPS(2), UPP1(3) 15194434 90 61 90 26 25 35 3 13 14 0 0.375 1.000 1.000 406 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT3(3), ARHGEF11(7), CDC42(1), DLG4(1), GNA13(1), LPA(15), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RDX(2), ROCK1(5), ROCK2(3), SERPINA4(7), SRF(2), TBXA2R(2) 13006015 94 61 94 30 22 31 4 23 14 0 0.617 1.000 1.000 407 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BCL2L1(1), CBL(3), CFLAR(2), CRKL(1), E2F1(2), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), IRS1(6), JAK1(2), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3CA(29), PIK3R1(2), RAF1(1), RPS6KB1(1), SHC1(2), SOCS3(1), SOS1(11), STAT5A(2), SYK(2) 9576466 91 60 77 21 37 26 2 15 11 0 0.109 1.000 1.000 408 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1G(3), FPR1(1), GNB1(1), HRAS(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(3), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(2), PIK3C2G(8), PLCB1(8), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(4) 10152689 83 59 82 33 19 35 6 14 9 0 0.890 1.000 1.000 409 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(4), ACADS(2), ACAT1(2), ACSM1(5), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(4), DDHD1(5), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), ILVBL(2), OXCT1(3), PDHA1(3), PDHA2(8), PLA1A(5), PRDX6(2), RDH11(1), RDH12(2), RDH13(1), RDH14(1) 10754671 88 59 88 36 25 31 2 16 14 0 0.888 1.000 1.000 410 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(1), DDX56(1), ENTPD7(2), EP400(9), ERCC3(1), FPGS(2), GCH1(2), GGH(2), IFIH1(4), MOV10L1(7), NUDT8(1), RAD54L(1), SETX(12), SKIV2L2(2), SMARCA2(4) 16616228 87 59 87 38 26 31 9 11 10 0 0.963 1.000 1.000 411 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(2), FUCA2(1), GALNS(3), GBA(4), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(19), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2), SPAM1(7) 9102561 81 59 81 24 19 23 6 23 10 0 0.371 1.000 1.000 412 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(2), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CLCA1(7), CLCA2(5), CLCA4(2), CNGA3(6), CNGA4(5), CNGB1(4), GNAL(1), GUCA1A(2), GUCA1C(1), PDE1C(12), PRKACB(3), PRKACG(1), PRKG1(6), PRKG2(4), PRKX(1) 8085363 74 59 74 19 17 33 5 8 11 0 0.187 1.000 1.000 413 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(2), FSHR(15), GJA4(1), INHA(3), LHCGR(9), MLH1(2), MSH5(3), NCOR1(7), NRIP1(3), PGR(4), PRLR(6), PTGER2(2), SMPD1(4), VDR(4), ZP2(2) 9271043 83 59 83 32 23 28 4 13 15 0 0.906 1.000 1.000 414 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(7), HRAS(5), ITGA1(4), ITGB1(5), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTK2(6), PXN(3), TLN1(6) 8657950 74 58 72 21 18 23 5 14 14 0 0.393 1.000 1.000 415 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT3(3), ANKRD6(1), APC(9), AXIN2(2), CER1(2), CSNK1A1(2), CTNNB1(4), DACT1(5), DKK1(4), DKK2(1), DKK4(1), DVL1(2), FSTL1(2), GSK3A(3), LRP1(15), MVP(2), NKD1(2), NKD2(2), PSEN1(3), SENP2(3), WIF1(5) 10726362 74 58 74 25 15 30 4 13 11 1 0.609 1.000 1.000 416 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(9), EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(5), EIF2AK1(1), EIF2AK3(8), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G3(4), EIF5(4), EIF5B(1), ETF1(2), GSPT2(1), PABPC1(4), PABPC3(9), PAIP1(2) 11591787 84 58 84 24 33 17 3 16 15 0 0.630 1.000 1.000 417 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), GNAS(7), GNB1(1), HRAS(5), IGF1R(1), ITGB1(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PTPRR(9), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(11), STAT3(2) 8747044 74 57 72 21 16 28 6 16 8 0 0.394 1.000 1.000 418 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(2), ACAT1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(13), AUH(1), BCAT1(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), MCCC1(5), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6) 11412041 82 57 82 23 24 24 5 15 14 0 0.466 1.000 1.000 419 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(3), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PCK2(1), PDHA1(3), PDHA2(8), PKLR(4) 12352756 76 57 76 40 23 25 4 14 10 0 0.993 1.000 1.000 420 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(1), C6(18), C7(12), ICAM1(2), IL1A(2), IL6(1), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELP(11), SELPLG(1), TNF(1), VCAM1(5) 6596132 74 57 74 19 16 25 6 13 14 0 0.265 1.000 1.000 421 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(2), ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(9), ATP7B(2), COX10(2), COX4I1(1), COX6B1(2), COX6C(1), NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(2), SDHB(2), UQCRB(1), UQCRFS1(2) 10101736 74 57 74 20 16 21 7 15 15 0 0.330 1.000 1.000 422 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(13), COL4A3(10), COL4A4(11), COL4A5(3), COL4A6(8), P4HB(4), SLC23A1(2), SLC23A2(3), SLC2A1(1), SLC2A3(6) 6655402 71 57 71 18 11 38 1 8 13 0 0.421 1.000 1.000 423 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(5), AGTR2(3), CMA1(2), COL4A1(10), COL4A2(13), COL4A3(10), COL4A4(11), COL4A5(3), COL4A6(8) 6707563 69 56 69 20 8 39 1 8 13 0 0.659 1.000 1.000 424 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(3), GALK2(1), GALT(1), GANAB(5), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(19), MGAM(5), PFKM(5), PFKP(2), PGM1(1) 8646403 64 56 64 28 17 22 3 12 10 0 0.845 1.000 1.000 425 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM2(1), CREB1(1), FOS(2), GNAI1(3), GNAS(7), GNB1(1), HRAS(5), JUN(3), MAP2K1(2), MAPK3(1), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAF1(1), RPS6KA3(1), SYT1(4) 9193464 87 56 85 25 28 30 7 13 9 0 0.409 1.000 1.000 426 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(6), CDC7(3), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), PRIM1(3), RFC1(1), RFC4(5), RFC5(1), RPA1(1), RPA2(1), RPA4(2), UBB(2), UBC(1) 13479647 68 55 68 22 24 16 1 15 12 0 0.626 1.000 1.000 427 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(2), CASP10(3), CASP7(2), CASP8(2), CFLAR(2), DAXX(3), DFFB(2), FADD(1), FAF1(1), JUN(3), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK1(2), PAK2(1), PRKDC(12), PTPN13(9), RB1(12), RIPK2(2), SPTAN1(4) 11001119 71 55 70 16 21 15 1 12 22 0 0.304 1.000 1.000 428 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(2), BLNK(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(7), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(2), SOS1(11), SYK(2), VAV1(7), VAV2(4), VAV3(1) 8477056 67 55 65 15 20 22 7 11 7 0 0.154 1.000 1.000 429 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), DBH(2), DCT(4), DDC(5), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), PNMT(2), TAT(1), TH(2), TPO(10), TYR(10) 8388822 76 55 76 25 15 34 2 16 9 0 0.436 1.000 1.000 430 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(8), DARS(1), EPRS(12), FARS2(2), HARS(2), IARS(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), RARS(4), SARS(3), TARS(3), WARS(4), WARS2(2), YARS(1) 8494670 59 54 59 13 22 16 3 11 7 0 0.197 1.000 1.000 431 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(7), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5) 6064524 66 53 66 22 17 20 6 16 7 0 0.690 1.000 1.000 432 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CLDN5(1), CLOCK(5), CRY1(3), CRY2(2), EIF4G2(2), ETV6(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(7), NR1D2(1), PER1(6), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), TUBB3(1), UCP3(3), UGP2(4), VAPA(1), ZFR(5) 9642096 67 53 67 18 15 20 5 17 10 0 0.475 1.000 1.000 433 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(7), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5) 6064524 66 53 66 22 17 20 6 16 7 0 0.690 1.000 1.000 434 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(2), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP4A22(2), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1) 12969310 69 53 69 23 14 29 4 12 10 0 0.600 1.000 1.000 435 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(3), PSPH(1), RDH11(1), RDH12(2), RDH13(1), RDH14(1), SARDH(6), SARS(3), SARS2(3), SDS(2), TARS(3), TARS2(4) 11290298 69 53 69 21 25 18 3 14 9 0 0.349 1.000 1.000 436 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(3), AGT(1), AGTR1(5), AGTR2(3), ANPEP(7), CMA1(2), CPA3(6), CTSA(3), CTSG(3), ENPEP(11), LNPEP(2), MAS1(3), MME(9), NLN(2), THOP1(1) 5602714 65 53 65 21 14 26 2 12 11 0 0.541 1.000 1.000 437 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3), MASP1(9), MASP2(1), MBL2(4) 5715871 71 52 71 22 16 25 7 11 12 0 0.542 1.000 1.000 438 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(1), ALOX15(3), ALOX15B(1), CYP2B6(4), CYP2C18(2), CYP2C19(7), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP4A22(2), CYP4F2(4), CYP4F3(2), DHRS4(1), EPHX2(3), GGT1(1), GPX5(2), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2) 10282907 72 52 72 33 23 23 9 7 10 0 0.906 1.000 1.000 439 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(5), ANAPC4(3), ANAPC5(5), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CDC27(3), CUL1(4), CUL3(12), FBXW11(1), FBXW7(10), ITCH(2), RBX1(1), SKP1(1), SKP2(2), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E2(2), UBE2E3(2), VHL(1), WWP1(3), WWP2(2) 10661306 72 52 70 21 17 18 8 11 18 0 0.681 1.000 1.000 440 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT3(3), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(3), PLD1(7), PLD2(2), PLD3(1), VN1R1(4) 11908451 71 52 70 20 19 24 3 12 13 0 0.261 1.000 1.000 441 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), AOX1(13), BCAT1(1), BCKDHB(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCL(1), MCCC1(5), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6), SDS(2) 9550784 72 52 72 18 20 22 5 15 10 0 0.312 1.000 1.000 442 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C8B(4), C9(3), MASP1(9) 5581646 70 51 70 24 15 26 7 11 11 0 0.697 1.000 1.000 443 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), CPT1B(3), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(3), PLCG2(4), PSPH(1), SARDH(6), SARS(3), TARS(3) 11103348 61 51 61 19 24 17 1 11 8 0 0.411 1.000 1.000 444 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(2), ALDOA(1), ALDOB(2), FBP2(1), FPGT(5), FUK(2), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), MTMR1(1), MTMR2(2), MTMR6(5), PFKFB1(5), PFKL(2), PFKM(5), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), RDH14(1), SORD(1), TPI1(3) 9849015 67 51 67 22 15 22 6 13 11 0 0.512 1.000 1.000 445 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), CREBBP(17), CTNNB1(4), DVL1(2), EP300(9), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(14), WNT1(1) 8758785 65 51 64 14 13 22 5 15 10 0 0.166 1.000 1.000 446 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHB(3), LDHC(3), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PKLR(4) 9763990 63 51 63 30 18 23 3 11 8 0 0.965 1.000 1.000 447 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(5), ARHGEF1(2), ARHGEF11(7), ARHGEF5(2), ARPC1A(4), BAIAP2(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(2), MYLK(8), OPHN1(3), PIP5K1A(4), PIP5K1B(2), PPP1R12B(5), ROCK1(5), TLN1(6), VCL(2) 12044969 69 51 68 21 27 18 2 13 9 0 0.527 1.000 1.000 448 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(8), CREB1(1), CREB5(3), DUSP4(2), DUSP6(2), EEF2K(5), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RAP1A(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), SHC1(2), SOS1(11), SOS2(7), TRAF3(3) 7812826 66 51 66 15 21 18 6 9 12 0 0.233 1.000 1.000 449 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(9), ATF2(3), BMP10(1), BMP4(1), BMP5(8), BMPR1A(3), BMPR2(1), CHRD(6), CTNNB1(4), DVL1(2), FZD1(1), MAP3K7(2), MEF2C(4), MYL2(2), NKX2-5(1), NPPB(1), RFC1(1), TGFB2(3), TGFBR2(3), TGFBR3(8), WNT1(1) 9613812 65 50 65 21 22 19 3 9 12 0 0.692 1.000 1.000 450 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(2), ACACB(9), ACADM(1), ACAT1(2), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SUCLA2(2), SUCLG2(1) 10492803 63 50 63 22 20 17 4 11 11 0 0.741 1.000 1.000 451 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BBOX1(2), DLST(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADHA(2), PLOD1(4), PLOD2(5), PLOD3(5), SDS(2), TMLHE(1) 9784000 71 50 71 30 12 24 7 15 13 0 0.914 1.000 1.000 452 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(2), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFB(2), FADD(1), JUN(3), MADD(5), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK1(2), PAK2(1), PRKDC(12), RB1(12), SPTAN1(4), TNF(1), TNFRSF1A(2), TRADD(1) 10424697 61 50 60 23 15 14 0 10 22 0 0.880 1.000 1.000 453 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(2), GNAS(7), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), NOX1(2), PIK3C2G(8), PLCB1(8), PPP1R12B(5), PRKCA(5), PTK2(6), RAF1(1), ROCK2(3) 6693867 60 49 59 19 13 23 3 12 9 0 0.713 1.000 1.000 454 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(2), DLST(2), FH(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(3), PDHA2(8), PDHX(1), PDK1(1), PDK2(2), PDK3(3), PDK4(3), PDP2(4), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 7507034 56 49 56 20 11 21 3 13 8 0 0.721 1.000 1.000 455 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(4), ADSL(1), ADSS(1), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(10), DARS(1), DDO(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), PC(2) 6914471 59 48 59 21 16 21 2 13 7 0 0.628 1.000 1.000 456 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(9), BCAR1(6), CTNNA1(2), CTNNA2(27), CTNNB1(4), PTK2(6), PXN(3), VCL(2) 5049791 61 48 61 25 17 24 3 9 8 0 0.845 1.000 1.000 457 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(7), CD2(1), CD33(3), CD5(2), CD7(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL3(1), IL4(2), ITGAX(9), TLR2(3), TLR4(10), TLR7(3), TLR9(2) 4931288 54 48 53 18 10 21 3 13 7 0 0.503 1.000 1.000 458 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(1), AKR1D1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(5), HADHB(3), LIPA(2), RDH11(1), RDH12(2), RDH13(1), RDH14(1), SLC27A5(4), SOAT1(1), SOAT2(2), SRD5A1(2) 8408353 59 48 59 19 14 23 0 15 7 0 0.461 1.000 1.000 459 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(2), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(3), DDOST(1), DPM1(1), FUT8(2), GANAB(5), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(3), RPN1(1), ST6GAL1(2), STT3B(1) 11216478 72 48 72 27 28 26 2 9 7 0 0.762 1.000 1.000 460 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(4), CHIT1(5), CMAS(2), CTBS(3), CYB5R1(2), GFPT1(1), GFPT2(3), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(5), NAGK(2), NPL(2), RENBP(2), UAP1(2) 7576689 61 48 61 16 9 25 3 11 13 0 0.311 1.000 1.000 461 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(3), CYP4F2(4), CYP4F3(2), EPX(5), GGT1(1), LPO(2), LTA4H(2), MPO(4), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PRDX1(1), PRDX6(2), PTGS1(2), PTGS2(1), TBXAS1(2), TPO(10) 7384189 62 48 62 29 12 22 9 11 8 0 0.921 1.000 1.000 462 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(3), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 7514232 60 48 58 20 16 20 5 14 5 0 0.704 1.000 1.000 463 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(2), FOS(2), IKBKB(2), IRAK1(4), JUN(3), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(1), RELA(3), TLR2(3), TLR3(2), TLR4(10), TLR7(3), TLR9(2), TOLLIP(1), TRAF6(5) 9644644 61 48 60 29 18 21 5 9 8 0 0.973 1.000 1.000 464 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), BTRC(1), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(2), CSNK2A1(2), CTBP1(2), CTNNB1(4), DVL1(2), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(2), TLE1(4), WIF1(5), WNT1(1) 7765622 62 48 62 14 18 19 6 8 11 0 0.227 1.000 1.000 465 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CPS1(28), GATM(1), NAGS(1), ODC1(1), OTC(3), SMS(2) 7788514 63 47 62 15 13 25 3 14 8 0 0.123 1.000 1.000 466 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(7), POLB(1), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLG(2), POLG2(2), POLI(3), POLK(3), POLL(2), POLQ(18), PRIM1(3), PRIM2(4), REV1(5), REV3L(4), RFC5(1) 10853991 69 47 69 21 22 20 1 15 11 0 0.662 1.000 1.000 467 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(9), DBH(2), DDC(5), GAD1(5), GAD2(6), HDC(6), PAH(3), PNMT(2), SLC18A3(8), TH(2), TPH1(2) 3804590 53 46 53 19 13 25 4 9 2 0 0.517 1.000 1.000 468 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(19), SPAM1(7) 5404724 51 46 51 15 12 16 2 12 9 0 0.405 1.000 1.000 469 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), BLVRB(1), CP(2), CPOX(2), EPRS(12), FECH(2), GUSB(2), HCCS(1), PPOX(1), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3), UGT2B15(3), UGT2B4(8), UROD(1), UROS(1) 7265216 55 45 55 15 11 23 5 11 5 0 0.390 1.000 1.000 470 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(7), DLG4(1), EPHB2(6), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RAF1(1), RASAL1(8), TEC(4), VAV1(7) 7256214 67 45 66 22 20 24 4 10 9 0 0.555 1.000 1.000 471 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CDC42(1), CREB1(1), CREB5(3), DUSP10(4), EEF2K(5), GADD45A(1), IL1R1(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK11(2), MAPK12(1), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK2(1), MYEF2(4), NFKB1(2), NR2C2(3), SRF(2), TRAF6(5) 8834077 61 45 61 22 22 21 4 6 8 0 0.759 1.000 1.000 472 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), NFAT5(3), PDE6A(4), PDE6B(3), PDE6C(1), PDE6H(2), SLC6A13(5), TF(6) 9499351 59 45 58 21 16 23 3 8 9 0 0.617 1.000 1.000 473 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(5), EGF(6), EGFR(7), FOS(2), HRAS(5), JUN(3), MYC(1), NFKB1(2), PLCG1(3), PRKCA(5), RELA(3) 5445118 52 44 49 17 13 19 3 8 9 0 0.562 1.000 1.000 474 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSD(1), ARSE(2), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(19), NEU1(3), NEU2(2), NEU4(2), PPAP2B(2), SMPD1(4), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(1) 6383971 54 44 54 17 14 19 3 12 6 0 0.445 1.000 1.000 475 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(1), DAXX(3), HRAS(5), HSPB2(1), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(4), MEF2D(3), MYC(1), PLA2G4A(7), RAC1(1), RPS6KA5(4), SHC1(2), STAT1(2), TGFB2(3), TRADD(1) 9723880 64 44 63 27 20 26 4 10 4 0 0.936 1.000 1.000 476 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(2), ACADL(2), ACADM(1), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1) 8753790 54 44 54 15 15 17 4 9 9 0 0.495 1.000 1.000 477 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(6), EGR3(2), MAP3K1(3), MYC(1), NFATC1(3), NFATC2(5), NFKB1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), SYT1(4), VIP(1), VIPR2(3) 7373715 60 44 60 18 15 21 5 9 10 0 0.463 1.000 1.000 478 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(2), ACADM(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(8), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), MLYCD(1), SDS(2), SMS(2) 7698099 61 43 61 23 14 23 3 11 10 0 0.744 1.000 1.000 479 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(4), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HMGCL(1), OXCT1(3), PDHA1(3), PDHA2(8), SDHB(2), SDS(2) 6826931 56 43 56 25 13 24 3 7 9 0 0.921 1.000 1.000 480 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3) 4705477 57 43 57 18 12 20 7 7 11 0 0.605 1.000 1.000 481 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(2), HDAC5(1), HRAS(5), JUN(3), NCOR2(7), RBL1(5), RBL2(7), SIN3A(5), SIN3B(3) 6870586 49 43 47 12 17 18 3 6 5 0 0.249 1.000 1.000 482 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACPP(1), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(7), CYP2C8(2), CYP2C9(3), CYP2D6(2), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), PON1(5) 7743427 66 43 66 30 21 17 4 16 8 0 0.911 1.000 1.000 483 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(3), CYP1A2(1), CYP2C18(2), CYP2C19(7), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1), RDH14(1) 6346784 54 43 54 18 21 16 6 4 7 0 0.513 1.000 1.000 484 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(13), BST1(1), CD38(2), ENPP1(8), ENPP3(6), NADK(1), NADSYN1(7), NMNAT2(2), NMNAT3(1), NNT(10), NT5C1A(2), NT5C1B(1), NT5C2(3), NT5E(2), NUDT12(2) 5697708 61 43 61 16 16 20 3 11 11 0 0.327 1.000 1.000 485 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(10), CAP1(1), CCNB1(2), CDC25C(1), GNAI1(3), GNAS(7), GNB1(1), HRAS(5), MAPK1(1), MAPK3(1), MYT1(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RPS6KA1(2) 5412451 52 43 51 20 10 17 6 14 5 0 0.845 1.000 1.000 486 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(17), EP300(9), IKBKB(2), IL1B(1), MAP2K3(3), MAP2K6(2), MAP3K7(2), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(1), RELA(3), TGFBR2(3), TLR2(3), TNF(1) 7847285 54 43 53 18 11 18 3 12 10 0 0.693 1.000 1.000 487 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), CSNK1D(2), DRD1(1), DRD2(4), GRM1(13), PLCB1(8), PPP1CA(1), PPP1R1B(1), PPP3CA(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 4237842 47 42 47 14 12 20 4 7 4 0 0.411 1.000 1.000 488 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(1), EPHB1(13), FYN(5), ITGA1(4), ITGB1(5), L1CAM(1), LYN(2), RAP1B(1), SELP(11) 4181179 46 42 46 24 6 16 3 10 11 0 0.989 1.000 1.000 489 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(2), DERA(1), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKL(2), PFKM(5), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(2), RBKS(1), RPIA(2), TALDO1(1), TKT(1), TKTL1(1), TKTL2(11) 6439869 49 42 49 15 4 20 5 8 12 0 0.406 1.000 1.000 490 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(6), ABCG2(3), BCHE(12), CES1(2), CES2(1), CYP3A4(1), UGT1A1(4), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A6(3), UGT1A7(2), UGT1A9(3) 6058731 47 42 47 13 8 20 3 12 4 0 0.310 1.000 1.000 491 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(17), EP300(9), LPL(3), NCOA1(6), NCOA2(12), RXRA(2) 4903643 49 42 48 17 10 18 3 11 7 0 0.793 1.000 1.000 492 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(2), F2RL3(1), GNAI1(3), GNB1(1), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(8), PRKCA(5), PTGS1(2), PTK2(6), RAF1(1), SYK(2), TBXAS1(2) 6440993 58 42 57 18 13 17 5 13 10 0 0.637 1.000 1.000 493 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(9), CAPN1(2), CAPNS2(1), ITGA1(4), ITGB1(5), ITGB3(4), PTK2(6), PXN(3), RAC1(1), SPTAN1(4), TLN1(6) 7542709 50 42 50 19 13 14 2 11 10 0 0.807 1.000 1.000 494 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(5), EPX(5), ESCO1(2), ESCO2(2), GOT2(3), HPD(1), LPO(2), MPO(4), PNPLA3(1), PRDX6(2), SH3GLB1(1), TAT(1), TPO(10) 9053784 47 41 47 26 8 16 4 13 6 0 0.987 1.000 1.000 495 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), NDST1(4), NDST2(2), NDST3(4), NDST4(14) 5457456 49 41 49 17 13 18 5 8 5 0 0.575 1.000 1.000 496 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(3), CREBBP(17), EP300(9), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(3), TGFBR2(3) 6794970 50 41 49 14 13 16 2 12 7 0 0.581 1.000 1.000 497 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(8), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HIBCH(1), MLYCD(1), SMS(2) 7147393 55 40 55 22 13 20 2 10 10 0 0.799 1.000 1.000 498 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(19), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2) 5380091 50 40 50 14 12 14 4 14 6 0 0.328 1.000 1.000 499 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), JAK2(4), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(2), STAT4(5), TYK2(8) 4919124 43 40 42 12 14 16 2 4 7 0 0.495 1.000 1.000 500 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(2), IL1A(2), IL1B(1), IL1R1(1), IL1RAP(2), IL6(1), IRAK1(4), IRAK2(1), IRAK3(4), JUN(3), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TGFB2(3), TNF(1), TOLLIP(1), TRAF6(5) 7824598 54 40 53 18 17 20 3 8 6 0 0.648 1.000 1.000 501 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), FADD(1), IKBKB(2), IL1A(2), IL1R1(1), IRAK1(4), MAP3K1(3), MAP3K7(2), NFKB1(2), RELA(3), TLR4(10), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 6444905 47 40 47 19 10 18 6 6 7 0 0.885 1.000 1.000 502 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA4(1), ANXA5(3), ANXA6(5), CYP11A1(2), EDNRA(1), EDNRB(5), HSD11B1(3), HSD11B2(1), PLA2G4A(7), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(1), TBXAS1(2) 5472131 50 40 50 18 8 18 4 9 11 0 0.687 1.000 1.000 503 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), CERK(6), CREB1(1), CREB5(3), DAG1(2), EPHB2(6), FOS(2), ITPKA(1), ITPKB(6), JUN(3), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1) 7529585 52 40 51 18 19 18 4 4 7 0 0.690 1.000 1.000 504 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(10), APOA4(3), APOC2(2), APOC3(2), CYP7A1(5), DGAT1(1), HMGCR(1), LDLR(4), LIPC(2), LPL(3), LRP1(15), SCARB1(3), SOAT1(1) 7263820 52 40 52 21 17 18 1 10 6 0 0.742 1.000 1.000 505 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(3), CHUK(2), GH1(2), GHR(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3) 3741089 48 39 34 11 28 6 3 8 3 0 0.345 1.000 1.000 506 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(2), ACO2(3), CLYBL(1), DLD(2), DLST(2), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), OGDHL(6), PC(2), PCK1(3), PCK2(1), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 7895341 45 39 45 24 8 18 1 10 8 0 0.973 1.000 1.000 507 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(2), PGK1(2), PGK2(4), PKLR(4), RPIA(2), TKT(1), TKTL1(1), TKTL2(11), TPI1(3) 5332929 46 39 46 19 8 17 6 7 8 0 0.790 1.000 1.000 508 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(2), FHL5(3), FSHB(2), FSHR(15), GNAS(7), XPO1(2) 2521554 41 38 41 15 11 10 4 14 2 0 0.864 1.000 1.000 509 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(1), ALDOB(2), FBP2(1), FPGT(5), GCK(5), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), PFKFB1(5), PFKM(5), PFKP(2), PMM1(1), SORD(1), TPI1(3) 6342149 49 38 49 18 14 18 3 7 7 0 0.588 1.000 1.000 510 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DDC(5), HAL(2), HARS(2), HDC(6), HNMT(3), PRPS1(2), PRPS2(2) 6463570 43 38 43 19 6 22 2 9 4 0 0.805 1.000 1.000 511 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXA(5), LCT(19), SLC33A1(3), ST3GAL1(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3) 4350925 46 38 46 14 13 18 2 6 7 0 0.307 1.000 1.000 512 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM2(1), CAPN2(2), CAPNS2(1), EP300(9), HDAC1(2), MEF2D(3), NFATC1(3), NFATC2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SYT1(4) 6450147 50 38 49 12 15 15 5 6 9 0 0.303 1.000 1.000 513 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(4), GNAS(7), PLCE1(13), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3892558 45 38 44 13 12 15 3 10 5 0 0.499 1.000 1.000 514 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3) 3367043 45 37 45 14 7 16 7 6 9 0 0.675 1.000 1.000 515 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(17), EP300(9), NCOA3(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RARA(1), RXRA(2) 5469179 46 37 45 13 9 17 2 13 5 0 0.500 1.000 1.000 516 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2R(2), F3(1), F5(18), F7(2), FGA(5), FGB(4), FGG(2), PROS1(5), SERPINC1(7) 4338527 49 37 49 13 17 14 6 9 3 0 0.477 1.000 1.000 517 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(5), EPX(5), GOT2(3), HPD(1), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TAT(1), TPO(10) 5808702 42 37 42 23 6 16 5 12 3 0 0.968 1.000 1.000 518 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(7), EEA1(3), GRASP(1), GSK3A(3), LYN(2), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PLCG1(3), PRKCE(3), PRKCZ(1), RAC1(1), RPS6KB1(1), VAV2(4) 6624084 44 37 44 20 8 13 7 6 10 0 0.947 1.000 1.000 519 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(6), NCOA2(12), NCOA3(4), NCOR2(7), POLR2A(2), RARA(1), RXRA(2) 6611801 42 37 42 19 8 18 2 8 6 0 0.922 1.000 1.000 520 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(2), MARCKS(1), NFATC1(3), NFATC2(5), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SP1(2), SP3(1), SYT1(4) 5518793 45 36 45 11 14 19 3 4 5 0 0.306 1.000 1.000 521 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPAT4(1), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(7), ENPP6(3), PAFAH1B1(1), PAFAH1B2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PPAP2B(2) 6155800 50 36 50 21 12 20 5 6 7 0 0.856 1.000 1.000 522 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(2), CASP1(1), CASP7(2), CASP8(2), GAPDH(2), INSR(9), ITCH(2), MAGI1(8), MAGI2(12), RERE(3), WWP1(3), WWP2(2) 6354020 50 36 50 16 10 16 2 12 10 0 0.668 1.000 1.000 523 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKM(5), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(2), RBKS(1), RPIA(2), TAL1(4), TALDO1(1), TKT(1) 5409298 38 36 38 14 4 13 3 6 12 0 0.642 1.000 1.000 524 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(3), GLI2(6), GLI3(9), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), SHH(2), SMO(1), SUFU(2) 4387307 40 36 40 15 12 15 4 5 4 0 0.697 1.000 1.000 525 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(3), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(5), HADHB(3), SOAT2(2), SRD5A1(2) 6160205 42 35 42 14 9 18 0 11 4 0 0.571 1.000 1.000 526 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(7), CR2(11), FCGR2B(3), HLA-DRA(1), HLA-DRB1(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7) 4044777 42 35 42 13 15 10 2 10 5 0 0.587 1.000 1.000 527 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2), TGFB2(3) 5290782 44 35 44 19 12 14 1 9 8 0 0.860 1.000 1.000 528 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(3), EGF(6), EGFR(7), MET(4), PDGFRA(7), PRKCA(5), SH3GLB1(1), SH3KBP1(4) 5134556 40 34 39 14 12 14 4 4 6 0 0.729 1.000 1.000 529 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(7), GNB1(1), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 4039205 39 34 39 11 9 13 5 7 5 0 0.531 1.000 1.000 530 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), LCMT2(1), MARS(1), MAT1A(1), METTL2B(1), METTL6(2), PAPSS2(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SCLY(1), SEPHS1(3), WBSCR22(3) 6596793 41 34 41 12 11 15 2 2 11 0 0.376 1.000 1.000 531 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(2), GALNT2(2), GALNT3(3), GALNT6(2), GALNT8(3), GALNT9(1), GCNT1(3), ST3GAL1(4), ST3GAL4(2), WBSCR17(11) 3817187 35 34 34 14 5 15 4 4 7 0 0.804 1.000 1.000 532 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(1), GTF2B(2), GTF2E1(2), GTF2H1(2), GTF2H4(2), ILK(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(6), POLR2E(1), POLR3B(1), POLR3D(2), POLR3E(4), POLR3H(2), TAF5(1), TAF9(2) 9272390 37 34 37 18 12 11 2 4 8 0 0.954 1.000 1.000 533 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(4), CFTR(8), GNAS(7), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3437821 40 33 40 11 13 13 3 8 3 0 0.433 1.000 1.000 534 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), DFFB(2), FADD(1), GAS2(3), NFKB1(2), RELA(3), SPTAN1(4), TNFRSF10A(1), TNFRSF10B(1), TRADD(1) 8861633 40 33 39 18 12 6 3 10 9 0 0.935 1.000 1.000 535 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), IDS(1), IDUA(2), LCT(19) 3778304 35 33 35 11 10 12 1 5 7 0 0.430 1.000 1.000 536 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP6(2), ACPP(1), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(5), TYR(10) 3953309 41 33 41 10 5 19 3 4 10 0 0.326 1.000 1.000 537 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(9), BTRC(1), CTNNB1(4), DLL1(1), DVL1(2), FZD1(1), NOTCH1(16), PSEN1(3), WNT1(1) 5624290 38 33 38 12 8 9 1 6 14 0 0.645 1.000 1.000 538 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(2), HRAS(5), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(8), PRKCA(5), RAF1(1), RELA(3), TNF(1) 4110222 37 32 35 12 12 12 4 6 3 0 0.601 1.000 1.000 539 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), KHK(2), LCT(19), MPI(1), PGM1(1), PYGL(3), PYGM(6), TPI1(3) 3554997 37 32 37 11 8 14 2 7 6 0 0.330 1.000 1.000 540 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(2), COASY(2), DPYD(8), DPYS(6), ENPP1(8), ENPP3(6), ILVBL(2), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1), VNN1(2) 4580363 42 32 42 14 10 15 4 4 9 0 0.651 1.000 1.000 541 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(7), CYP2C9(3), DHRS2(3), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(2), HADHA(2), PNPLA3(1), SH3GLB1(1) 8187108 37 32 37 16 12 12 0 4 9 0 0.880 1.000 1.000 542 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(5), TYK2(8) 3880627 34 32 34 10 8 11 2 5 8 0 0.553 1.000 1.000 543 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), DAB1(6), FYN(5), RELN(32) 3715868 45 32 45 14 14 13 5 11 0 2 0.669 1.000 1.000 544 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(3), DLD(2), DLST(2), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), PC(2), PCK1(3), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 5454441 34 31 34 12 7 13 1 6 7 0 0.657 1.000 1.000 545 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(2), GNA13(1), GNB1(1), MYL2(2), MYLK(8), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 5481718 41 31 41 12 13 13 2 6 7 0 0.605 1.000 1.000 546 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(1), BIRC3(3), CASP8(2), CFLAR(2), FADD(1), JUN(3), MAP2K4(1), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NR2C2(3), RALBP1(1), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 7209380 39 31 38 13 12 17 2 3 5 0 0.579 1.000 1.000 547 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10), TYR(10) 2553458 34 31 34 10 6 15 4 5 4 0 0.387 1.000 1.000 548 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(4), IKBKB(2), LTA(2), MAP3K1(3), NFKB1(2), RELA(3), TANK(4), TNFAIP3(5), TNFRSF1B(1), TRAF1(4), TRAF3(3) 5949035 35 31 35 11 3 8 3 11 10 0 0.663 1.000 1.000 549 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PGK1(2), PKLR(4), RPIA(2), TKT(1), TPI1(3) 4768734 33 30 33 16 8 10 2 5 8 0 0.888 1.000 1.000 550 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTAP(1), MTR(7), TAT(1) 5477009 34 30 34 13 11 9 1 7 6 0 0.747 1.000 1.000 551 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), FUT2(1), FUT3(3), FUT5(5), FUT6(2), FUT9(5), GCNT2(2), ST3GAL6(2), ST8SIA1(3) 4260727 36 30 36 12 7 16 5 5 3 0 0.497 1.000 1.000 552 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(1), FTCD(3), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(7) 5021303 31 29 31 10 13 9 2 4 3 0 0.563 1.000 1.000 553 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(4), MEF2D(3), PPARA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(4) 5349630 37 29 37 13 11 14 4 4 4 0 0.651 1.000 1.000 554 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP6(2), ACPP(1), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CMBL(3), CYP3A4(1), CYP3A43(4), CYP3A7(1), DHRS2(3), DHRSX(4), PON1(5), PON2(1), PON3(2) 4754337 39 28 39 13 10 13 2 7 7 0 0.526 1.000 1.000 555 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), AOC2(2), AOC3(3), CES1(2), DDHD1(5), ESCO1(2), ESCO2(2), LIPA(2), PLA1A(5), PNPLA3(1), PRDX6(2), SH3GLB1(1) 6727165 30 28 30 12 7 10 0 8 5 0 0.826 1.000 1.000 556 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(2), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(4), JAK3(7), SOCS3(1), STAT1(2), STAT3(2), STAT5A(2), TYK2(8) 4866410 34 28 34 10 9 14 2 4 5 0 0.341 1.000 1.000 557 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(1), SCAP(5), SREBF1(2), SREBF2(3) 4815085 32 28 31 12 10 7 2 8 5 0 0.751 1.000 1.000 558 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TANK(4), TNF(1), TNFRSF1A(2), TRADD(1) 6394207 37 28 36 17 9 11 2 8 7 0 0.915 1.000 1.000 559 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(11), MAP2(9), PPP1CA(1), PRKACB(3), PRKACG(1), PRKAR2B(3), PRKCE(3) 4825175 31 27 31 10 8 12 2 5 4 0 0.798 1.000 1.000 560 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(7), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(7), RARA(1), RXRA(2), THRA(1), THRB(2) 4562313 32 27 31 14 6 14 0 9 3 0 0.858 1.000 1.000 561 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS(1), LARS2(3), PDHA1(3), PDHA2(8), VARS(5), VARS2(2) 4915355 33 27 33 10 7 15 2 6 3 0 0.518 1.000 1.000 562 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(7), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL34(1), RPL37(1), RPL3L(2), RPL7(1), RPL8(2), RPS11(1), RPS12(1), RPS18(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS8(2) 6000808 29 27 29 13 10 8 0 7 4 0 0.811 1.000 1.000 563 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTR(7) 4607304 31 27 31 12 9 9 1 7 5 0 0.752 1.000 1.000 564 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(2), ESR1(6), GREB1(13), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1) 2906466 27 27 27 13 3 12 2 9 1 0 0.891 1.000 1.000 565 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(1), B4GALT3(3), B4GALT5(2), DDOST(1), DPM1(1), FUT8(2), MAN1A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), RPN1(1), ST6GAL1(2) 5249675 35 27 35 17 12 15 2 4 2 0 0.892 1.000 1.000 566 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(1), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(7) 4751037 28 27 28 10 13 8 1 4 2 0 0.653 1.000 1.000 567 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(8), DPYS(6), ENPP1(8), ENPP3(6), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1) 3688257 36 27 36 13 9 12 3 3 9 0 0.775 1.000 1.000 568 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(8), PLCB2(5), PRL(1), VIP(1) 2937008 29 27 29 14 8 13 0 5 3 0 0.925 1.000 1.000 569 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL4(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(3), NFATC2(5), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3178644 32 26 32 14 7 14 2 4 5 0 0.785 1.000 1.000 570 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), CHST1(3), CHST2(5), CHST4(2), CHST6(5), FUT8(2), ST3GAL1(4), ST3GAL4(2) 3311497 32 26 32 12 7 21 2 2 0 0 0.477 1.000 1.000 571 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(1), PGAP1(4), PIGB(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGW(2), PIGX(1), PIGZ(2) 6353638 29 26 29 16 5 11 3 4 6 0 0.941 1.000 1.000 572 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), GBA(4), LPO(2), MPO(4), PRDX6(2), TPO(10) 2222900 27 26 27 10 6 9 4 6 2 0 0.661 1.000 1.000 573 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF9(1) 5147145 30 25 29 10 10 7 2 7 4 0 0.722 1.000 1.000 574 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(5), AGTR2(3), BDKRB2(3), KNG1(9), NOS3(2) 2623263 27 25 27 10 5 12 2 4 4 0 0.609 1.000 1.000 575 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(4), COPS5(3), CREB1(1), EP300(9), HIF1A(1), JUN(3), NOS3(2), P4HB(4), VHL(1) 4490412 29 25 27 13 10 7 0 9 3 0 0.933 1.000 1.000 576 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(3), HDAC9(16), MEF2A(2), MEF2C(4), MEF2D(3), MYOD1(1) 2078409 29 25 29 10 9 12 1 5 2 0 0.652 1.000 1.000 577 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), ARHGDIB(2), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(1) 5115374 30 24 29 13 9 6 1 7 7 0 0.922 1.000 1.000 578 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCR5(1), CXCR4(5), FOS(2), JUN(3), MAPK14(1), MAPK8(2), PLCG1(3), PRKCA(5), SYT1(4) 3642690 27 24 26 11 11 9 3 3 1 0 0.786 1.000 1.000 579 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(2), FADD(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(2), NSMAF(4), RAF1(1), RELA(3), SMPD1(4), TNFRSF1A(2), TRADD(1) 5437653 31 24 31 16 8 8 1 8 6 0 0.960 1.000 1.000 580 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), EPX(5), LPO(2), MPO(4), MTHFR(2), PRDX6(2), TPO(10) 3083778 26 24 26 12 7 9 3 5 2 0 0.834 1.000 1.000 581 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), EPX(5), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10) 3125991 25 24 25 13 6 8 4 5 2 0 0.917 1.000 1.000 582 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(17), DFFB(2), GZMA(4), GZMB(1), HMGB2(1), PRF1(1) 2800041 27 24 27 10 5 10 2 6 4 0 0.739 1.000 1.000 583 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(3), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2) 3366449 29 24 29 10 12 7 0 4 6 0 0.742 1.000 1.000 584 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ARPC1A(4), NCK1(2), NCKAP1(7), NTRK1(4), RAC1(1), WASF1(1), WASF3(1), WASL(2) 4043146 25 23 24 16 6 7 0 6 6 0 0.995 1.000 1.000 585 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(3), DHRSX(4), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 6626342 27 23 27 10 9 9 0 3 6 0 0.750 1.000 1.000 586 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(1), DHRS2(3), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(2), FN3K(1), GCDH(2), HADHA(2), PNPLA3(1), SH3GLB1(1) 6883700 23 22 23 12 6 5 1 4 7 0 0.953 1.000 1.000 587 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(2), CHPF(2), CHST11(2), CHST12(1), CHST3(2), CHSY1(2), DSE(4), UST(1), XYLT1(6) 3682842 24 21 24 13 3 9 1 8 3 0 0.928 1.000 1.000 588 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(1), SNAP23(1), SNAP25(1), STX10(1), STX11(2), STX16(1), STX19(2), STX2(1), STX5(2), STX7(1), TSNARE1(2), USE1(1), VAMP7(3), YKT6(1) 4401377 22 21 22 10 7 4 3 4 4 0 0.905 1.000 1.000 589 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(5), CSF1(2), FCGR3A(5), IL1B(1), IL6R(1), SELL(2), TGFB2(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1) 3534805 28 21 28 11 7 10 2 4 5 0 0.765 1.000 1.000 590 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(3), ALOX15B(1), DPEP1(3), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2) 3982745 22 19 22 9 4 14 1 3 0 0 0.625 1.000 1.000 591 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(2), GPR45(4), GPR65(3), GPR68(1), GPR75(2) 2609365 22 19 22 12 8 7 0 6 1 0 0.826 1.000 1.000 592 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2) 6225063 21 19 21 14 9 5 1 1 5 0 0.984 1.000 1.000 593 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(4), CASP9(3), DAXX(3), FAS(1), FASLG(1), HSPB2(1), IL1A(2), MAPKAPK2(1), MAPKAPK3(1), TNF(1) 2998501 21 19 20 13 8 5 1 4 3 0 0.983 1.000 1.000 594 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD8A(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 2844225 21 19 21 9 6 6 1 8 0 0 0.836 1.000 1.000 595 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 2987610 20 19 20 10 6 5 1 7 1 0 0.910 1.000 1.000 596 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(2), ARHGDIB(2), CASP1(1), CASP10(3), CASP8(2), CASP9(3), GZMB(1), JUN(3), PRF1(1) 3419095 22 17 20 10 10 3 1 4 4 0 0.930 1.000 1.000 597 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(2), FLT3(7), IGF1(3), IL1A(2), IL3(1), IL6(1), TGFB2(3) 2203477 19 17 19 10 6 7 1 4 1 0 0.924 1.000 1.000 598 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ATF3(1), HBEGF(1), IFNG(1), IL1A(2), IL1R1(1), JUND(2), MYOG(1), NR4A3(3), WDR1(2) 2849921 18 17 18 10 5 6 1 0 6 0 0.969 1.000 1.000 599 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(9), FASN(2), MCAT(1), OLAH(2), OXSM(1) 4199649 17 15 17 14 8 5 1 1 2 0 0.990 1.000 1.000 600 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(1), SIRT1(1), SIRT2(3), SIRT7(2), VNN2(5) 3143630 17 15 17 10 2 6 1 4 4 0 0.969 1.000 1.000 601 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(3), B4GALT5(2), FUT8(2), ST3GAL1(4), ST3GAL4(2) 2084891 14 14 14 10 4 7 1 2 0 0 0.973 1.000 1.000 602 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(3), B3GALT2(3), FUT2(1), FUT3(3), ST3GAL4(2) 1910628 12 12 12 6 5 3 2 2 0 0 0.856 1.000 1.000 603 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(3), NR3C1(1), RXRA(2), TNF(1) 1532756 10 10 10 6 3 5 0 2 0 0 0.897 1.000 1.000 604 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 MDH1(1), ME1(2), PC(2), PDHA1(3), SLC25A11(1) 2451814 9 9 9 10 3 2 0 2 2 0 0.995 1.000 1.000 605 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(6) 1707422 9 8 9 6 1 6 0 2 0 0 0.865 1.000 1.000 606 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(6) 1707422 9 8 9 6 1 6 0 2 0 0 0.865 1.000 1.000 607 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP54(1), SRP72(2), SRPR(2) 1995421 7 7 7 3 2 2 2 1 0 0 0.861 1.000 1.000 608 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3) 1032376 7 7 7 4 2 3 0 2 0 0 0.872 1.000 1.000 609 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB4A(3) 1138299 7 7 7 13 1 5 0 0 1 0 1.000 1.000 1.000 610 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), AOC3(3), CES1(2) 1596358 7 6 7 5 0 2 0 5 0 0 0.952 1.000 1.000 611 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(4), SNAP25(1) 864662 5 5 5 3 3 1 0 1 0 0 0.829 1.000 1.000 612 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(4), GGT1(1) 1473049 5 5 5 5 1 2 1 1 0 0 0.973 1.000 1.000 613 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(2), PTGS2(1) 1415436 5 4 5 4 1 2 0 2 0 0 0.936 1.000 1.000 614 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(1) 1066254 2 2 2 2 0 0 0 2 0 0 0.962 1.000 1.000 615 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1104238 1 1 1 4 0 1 0 0 0 0 0.998 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 405624 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000