Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer -0.031 0.128 -9999.0 0.0 -0.556 28.0 28.0 alphaV beta3 Integrin -0.024 0.107 -9999.0 0.0 -0.494 24.0 24.0 PTK2 -0.189 0.231 -9999.0 0.0 -0.7 43.0 43.0 IGF1R 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI4KB 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B -0.224 0.288 -9999.0 0.0 -0.583 189.0 189.0 VEGFA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ILK -0.224 0.288 -9999.0 0.0 -0.583 189.0 189.0 ROCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.208 0.267 -9999.0 0.0 -0.541 189.0 189.0 PTK2B 0.002 0.134 -9999.0 0.0 -0.797 7.0 7.0 alphaV/beta3 Integrin/JAM-A -0.173 0.221 -9999.0 0.0 -0.836 13.0 13.0 CBL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 -0.013 0.076 -9999.0 0.0 -0.478 11.0 11.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.016 0.081 -9999.0 0.0 -0.431 18.0 18.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.117 0.162 -9999.0 0.0 -0.657 20.0 20.0 alphaV/beta3 Integrin/Syndecan-1 -0.011 0.073 -9999.0 0.0 -0.476 12.0 12.0 PI4KA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.041 0.143 -9999.0 0.0 -0.777 11.0 11.0 PI4 Kinase 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Osteopontin -0.187 0.183 -9999.0 0.0 -0.591 11.0 11.0 RPS6KB1 -0.038 0.132 -9999.0 0.0 -0.715 11.0 11.0 TLN1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.101 0.176 -9999.0 0.0 -0.754 24.0 24.0 GPR124 -0.001 0.033 -9999.0 0.0 -0.737 1.0 1.0 MAPK1 -0.101 0.176 -9999.0 0.0 -0.754 24.0 24.0 PXN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Tumstatin -0.307 0.246 -9999.0 0.0 -0.491 313.0 313.0 cell adhesion -0.014 0.073 -9999.0 0.0 -0.441 11.0 11.0 ANGPTL3 -0.005 0.051 -9999.0 0.0 -0.575 4.0 4.0 VEGFR2 homodimer/VEGFA homodimer/Src -0.027 0.109 -9999.0 0.0 -0.476 28.0 28.0 IGF-1R heterotetramer 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 -0.054 0.193 -9999.0 0.0 -0.737 37.0 37.0 ITGB3 -0.016 0.108 -9999.0 0.0 -0.737 11.0 11.0 IGF1 -0.028 0.139 -9999.0 0.0 -0.729 19.0 19.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion -0.011 0.072 -9999.0 0.0 -0.474 12.0 12.0 apoptosis 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD47 -0.004 0.057 -9999.0 0.0 -0.737 3.0 3.0 alphaV/beta3 Integrin/CD47 -0.013 0.078 -9999.0 0.0 -0.476 14.0 14.0 VCL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Del1 -0.04 0.137 -9999.0 0.0 -0.498 40.0 40.0 CSF1 -0.006 0.066 -9999.0 0.0 -0.737 4.0 4.0 PIK3C2A -0.224 0.288 -9999.0 0.0 -0.583 189.0 189.0 PI4 Kinase/Pyk2 -0.161 0.21 -9999.0 0.0 -0.757 25.0 25.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.033 0.135 -9999.0 0.0 -0.522 32.0 32.0 FAK1/Vinculin -0.145 0.178 -9999.0 0.0 -0.515 43.0 43.0 alphaV beta3/Integrin/ppsTEM5 -0.011 0.073 -9999.0 0.0 -0.476 12.0 12.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VTN -0.28 0.357 -9999.0 0.0 -0.735 191.0 191.0 BCAR1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 -0.021 0.121 -9999.0 0.0 -0.737 14.0 14.0 F11R 0.004 0.095 -9999.0 0.0 -0.556 14.0 14.0 alphaV/beta3 Integrin/Lactadherin -0.01 0.07 -9999.0 0.0 -0.476 11.0 11.0 alphaV/beta3 Integrin/TGFBR2 -0.045 0.158 -9999.0 0.0 -0.55 41.0 41.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas -0.003 0.038 -9999.0 0.0 -0.431 4.0 4.0 HSP90AA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin -0.01 0.064 -9999.0 0.0 -0.438 11.0 11.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 -0.019 0.117 -9999.0 0.0 -0.737 13.0 13.0 alphaV/beta3 Integrin/Pyk2 -0.031 0.126 -9999.0 0.0 -0.804 7.0 7.0 SDC1 -0.001 0.033 -9999.0 0.0 -0.737 1.0 1.0 VAV3 0.031 0.043 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FAK1/Paxillin -0.145 0.178 -9999.0 0.0 -0.515 43.0 43.0 cell migration -0.126 0.163 -9999.0 0.0 -0.488 32.0 32.0 ITGAV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.154 0.198 -9999.0 0.0 -0.757 13.0 13.0 SPP1 -0.293 0.288 -9999.0 0.0 -0.575 255.0 255.0 KDR -0.041 0.169 -9999.0 0.0 -0.737 28.0 28.0 mol:PI-4-5-P2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 COL4A3 -0.461 0.357 -9999.0 0.0 -0.737 313.0 313.0 angiogenesis -0.112 0.223 -9999.0 0.0 -0.745 26.0 26.0 Rac1/GTP -0.004 0.036 -9999.0 0.0 -9999.0 0.0 0.0 EDIL3 -0.046 0.178 -9999.0 0.0 -0.737 31.0 31.0 cell proliferation -0.045 0.157 -9999.0 0.0 -0.547 41.0 41.0