Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.432 0.294 -9999.0 0.0 -0.693 233.0 233.0 IHH -0.466 0.383 -9999.0 0.0 -0.808 278.0 278.0 SHH Np/Cholesterol/GAS1 -0.069 0.164 -9999.0 0.0 -0.443 78.0 78.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.068 0.162 0.439 78.0 -9999.0 0.0 78.0 SMO/beta Arrestin2 -0.359 0.249 -9999.0 0.0 -0.591 239.0 239.0 SMO -0.379 0.27 -9999.0 0.0 -0.627 240.0 240.0 AKT1 -0.15 0.109 -9999.0 0.0 -0.34 1.0 1.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.049 -9999.0 0.0 -0.629 3.0 3.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.372 0.265 -9999.0 0.0 -0.616 240.0 240.0 STIL -0.325 0.245 -9999.0 0.0 -0.525 258.0 258.0 DHH N/PTCH2 -0.046 0.155 -9999.0 0.0 -0.56 41.0 41.0 DHH N/PTCH1 -0.363 0.244 -9999.0 0.0 -0.575 246.0 246.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.053 0.19 -9999.0 0.0 -0.737 36.0 36.0 PTHLH -0.583 0.355 -9999.0 0.0 -0.92 233.0 233.0 determination of left/right symmetry -0.372 0.265 -9999.0 0.0 -0.616 240.0 240.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.576 0.348 -9999.0 0.0 -0.906 233.0 233.0 IHH N/Hhip -0.644 0.377 -9999.0 0.0 -0.813 396.0 396.0 DHH N/Hhip -0.401 0.295 -9999.0 0.0 -0.593 339.0 339.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.372 0.265 -9999.0 0.0 -0.616 240.0 240.0 pancreas development -0.485 0.349 -9999.0 0.0 -0.736 330.0 330.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.098 -9999.0 0.0 -0.737 9.0 9.0 somite specification -0.372 0.265 -9999.0 0.0 -0.616 240.0 240.0 SHH Np/Cholesterol/PTCH1 -0.347 0.249 -9999.0 0.0 -0.553 256.0 256.0 SHH Np/Cholesterol/PTCH2 -0.066 0.156 -9999.0 0.0 -0.429 77.0 77.0 SHH Np/Cholesterol/Megalin -0.279 0.265 -9999.0 0.0 -0.493 281.0 281.0 SHH -0.062 0.198 -9999.0 0.0 -0.543 72.0 72.0 catabolic process -0.37 0.251 -9999.0 0.0 -0.568 288.0 288.0 SMO/Vitamin D3 -0.368 0.263 -9999.0 0.0 -0.589 255.0 255.0 SHH Np/Cholesterol/Hhip -0.348 0.257 -9999.0 0.0 -0.498 349.0 349.0 LRP2 -0.368 0.369 -9999.0 0.0 -0.737 250.0 250.0 receptor-mediated endocytosis -0.491 0.309 -9999.0 0.0 -0.71 289.0 289.0 SHH Np/Cholesterol/BOC -0.063 0.153 -9999.0 0.0 -0.428 74.0 74.0 SHH Np/Cholesterol/CDO -0.066 0.155 -9999.0 0.0 -0.438 70.0 70.0 mesenchymal cell differentiation 0.345 0.255 0.494 349.0 -9999.0 0.0 349.0 mol:Vitamin D3 -0.346 0.258 -9999.0 0.0 -0.559 256.0 256.0 IHH N/PTCH2 -0.303 0.267 -9999.0 0.0 -0.537 278.0 278.0 CDON -0.007 0.073 -9999.0 0.0 -0.737 5.0 5.0 IHH N/PTCH1 -0.375 0.255 -9999.0 0.0 -0.577 288.0 288.0 Megalin/LRPAP1 -0.277 0.278 -9999.0 0.0 -0.556 250.0 250.0 PTCH2 -0.008 0.075 -9999.0 0.0 -0.683 6.0 6.0 SHH Np/Cholesterol -0.062 0.153 -9999.0 0.0 -0.433 72.0 72.0 PTCH1 -0.372 0.252 -9999.0 0.0 -0.571 288.0 288.0 HHIP -0.486 0.35 -9999.0 0.0 -0.737 330.0 330.0