Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 -0.026 0.137 -9999.0 0.0 -0.737 18.0 18.0 ENAH 0.058 0.023 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.023 0.118 -9999.0 0.0 -0.629 18.0 18.0 EPHA2 -0.004 0.057 -9999.0 0.0 -0.737 3.0 3.0 MYO6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.017 0.089 -9999.0 0.0 -0.476 18.0 18.0 AQP5 -0.171 0.253 -9999.0 0.0 -0.546 157.0 157.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.107 0.171 -9999.0 0.0 -0.381 141.0 141.0 EGF -0.014 0.097 -9999.0 0.0 -0.689 10.0 10.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.076 0.189 -9999.0 0.0 -0.546 70.0 70.0 cortical microtubule organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.002 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.033 -9999.0 0.0 -0.431 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.044 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.002 0.03 -9999.0 0.0 -0.395 3.0 3.0 CDH1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.017 0.076 -9999.0 0.0 -0.753 1.0 1.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.028 0.139 -9999.0 0.0 -0.729 19.0 19.0 DIAPH1 -0.023 0.119 -9999.0 0.0 -0.641 18.0 18.0 Wnt receptor signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.002 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.002 0.028 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.109 0.174 -9999.0 0.0 -0.387 141.0 141.0 HGF/MET -0.081 0.153 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.159 0.303 -9999.0 0.0 -0.737 108.0 108.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.068 0.029 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.039 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.002 0.021 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.053 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.014 0.069 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.004 0.053 -9999.0 0.0 -0.683 3.0 3.0 PLEKHA7 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.003 0.033 -9999.0 0.0 -0.428 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0