LPA receptor mediated events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GNB1/GNG2 -0.009 0.079 -9999.0 0.0 -0.663 6.0 6.0 NF kappa B1 p50/RelA/I kappa B alpha -0.017 0.046 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.056 0.135 -9999.0 0.0 -0.385 64.0 64.0 mol:PIP3 -0.02 0.077 -9999.0 0.0 -0.581 3.0 3.0 AKT1 -0.006 0.05 -9999.0 0.0 -0.567 3.0 3.0 PTK2B 0.017 0.037 -9999.0 0.0 -0.345 2.0 2.0 RHOA 0.027 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CB 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.081 -9999.0 0.0 -0.446 3.0 3.0 MAGI3 -0.001 0.033 -9999.0 0.0 -0.737 1.0 1.0 RELA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.011 0.057 -9999.0 0.0 -0.409 6.0 6.0 HRAS/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of microtubule depolymerization 0.024 0.06 -9999.0 0.0 -0.394 8.0 8.0 NF kappa B1 p50/RelA -0.023 0.065 -9999.0 0.0 -0.642 1.0 1.0 endothelial cell migration 0.016 0.087 -9999.0 0.0 -0.819 5.0 5.0 ADCY4 0.017 0.097 -9999.0 0.0 -0.614 6.0 6.0 ADCY5 0.012 0.094 -9999.0 0.0 -0.655 4.0 4.0 ADCY6 0.031 0.069 -9999.0 0.0 -0.587 4.0 4.0 ADCY7 0.032 0.067 -9999.0 0.0 -0.658 3.0 3.0 ADCY1 0.032 0.068 -9999.0 0.0 -0.658 3.0 3.0 ADCY2 0.018 0.081 -9999.0 0.0 -0.596 4.0 4.0 ADCY3 0.032 0.067 -9999.0 0.0 -0.658 3.0 3.0 ADCY8 -0.036 0.12 -9999.0 0.0 -0.654 5.0 5.0 ADCY9 0.031 0.072 -9999.0 0.0 -0.652 4.0 4.0 GSK3B 0.024 0.035 -9999.0 0.0 -0.375 1.0 1.0 arachidonic acid secretion 0.035 0.069 -9999.0 0.0 -0.584 4.0 4.0 GNG2 -0.007 0.073 -9999.0 0.0 -0.736 5.0 5.0 TRIP6 -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GNAO1 0.018 0.062 -9999.0 0.0 -0.544 5.0 5.0 HRAS 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA 0.017 0.073 -9999.0 0.0 -0.377 1.0 1.0 GAB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 lamellipodium assembly -0.003 0.058 -9999.0 0.0 -0.92 2.0 2.0 JUN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPA/LPA2/NHERF2 -0.003 0.038 -9999.0 0.0 -0.48 3.0 3.0 TIAM1 -0.004 0.069 -9999.0 0.0 -1.092 2.0 2.0 PIK3R1 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.001 0.082 -9999.0 0.0 -0.455 3.0 3.0 PLCB3 0.022 0.036 -9999.0 0.0 -0.432 3.0 3.0 FOS -0.09 0.241 -9999.0 0.0 -0.737 61.0 61.0 positive regulation of mitosis 0.035 0.069 -9999.0 0.0 -0.584 4.0 4.0 LPA/LPA1-2-3 -0.013 0.071 -9999.0 0.0 -0.483 6.0 6.0 mol:Ca ++ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 stress fiber formation 0.025 0.047 -9999.0 0.0 -0.419 2.0 2.0 GNAZ 0.014 0.073 -9999.0 0.0 -0.516 8.0 8.0 EGFR/PI3K-beta/Gab1 -0.02 0.08 -9999.0 0.0 -0.614 3.0 3.0 positive regulation of dendritic cell cytokine production -0.013 0.071 -9999.0 0.0 -0.479 6.0 6.0 LPA/LPA2/MAGI-3 -0.002 0.023 -9999.0 0.0 -0.48 1.0 1.0 ARHGEF1 -0.003 0.04 -9999.0 0.0 -0.542 2.0 2.0 GNAI2 0.02 0.049 -9999.0 0.0 -0.636 2.0 2.0 GNAI3 0.02 0.049 -9999.0 0.0 -0.429 5.0 5.0 GNAI1 0.019 0.064 -9999.0 0.0 -0.511 5.0 5.0 LPA/LPA3 -0.014 0.077 -9999.0 0.0 -0.459 14.0 14.0 LPA/LPA2 -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPA/LPA1 -0.005 0.054 -9999.0 0.0 -0.503 5.0 5.0 HB-EGF/EGFR -0.05 0.14 -9999.0 0.0 -0.412 61.0 61.0 HBEGF -0.025 0.145 -9999.0 0.0 -0.479 45.0 45.0 mol:DAG -0.001 0.082 -9999.0 0.0 -0.455 3.0 3.0 cAMP biosynthetic process 0.02 0.075 -9999.0 0.0 -0.655 4.0 4.0 NFKB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNB1 -0.001 0.033 -9999.0 0.0 -0.738 1.0 1.0 LYN 0.015 0.084 -9999.0 0.0 -0.553 3.0 3.0 GNAQ -0.009 0.05 -9999.0 0.0 -0.383 5.0 5.0 LPAR2 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LPAR3 -0.017 0.103 -9999.0 0.0 -0.622 14.0 14.0 LPAR1 -0.004 0.055 -9999.0 0.0 -0.828 2.0 2.0 IL8 0.001 0.131 -9999.0 0.0 -0.436 19.0 19.0 PTK2 0.021 0.072 -9999.0 0.0 -0.448 6.0 6.0 Rac1/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 -0.011 0.058 -9999.0 0.0 -0.411 6.0 6.0 EGFR -0.015 0.119 -9999.0 0.0 -0.629 18.0 18.0 PLCG1 -0.016 0.084 -9999.0 0.0 -0.357 10.0 10.0 PLD2 0.021 0.072 -9999.0 0.0 -0.448 6.0 6.0 G12/G13 -0.004 0.043 -9999.0 0.0 -0.583 2.0 2.0 PI3K-beta -0.007 0.061 -9999.0 0.0 -0.687 3.0 3.0 cell migration 0.002 0.032 -9999.0 0.0 -0.26 2.0 2.0 SLC9A3R2 -0.004 0.057 -9999.0 0.0 -0.737 3.0 3.0 PXN 0.025 0.048 -9999.0 0.0 -0.428 2.0 2.0 HRAS/GTP -0.009 0.066 -9999.0 0.0 -0.609 4.0 4.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP9 -0.032 0.132 -9999.0 0.0 -0.575 28.0 28.0 PRKCE 0.008 0.033 -9999.0 0.0 -0.739 1.0 1.0 PRKCD 0.006 0.079 -9999.0 0.0 -0.466 2.0 2.0 Gi(beta/gamma) -0.01 0.078 -9999.0 0.0 -0.651 5.0 5.0 mol:LPA -0.001 0.016 -9999.0 0.0 -0.211 2.0 2.0 TRIP6/p130 Cas/FAK1/Paxillin -0.001 0.059 -9999.0 0.0 -0.641 1.0 1.0 MAPKKK cascade 0.035 0.069 -9999.0 0.0 -0.584 4.0 4.0 contractile ring contraction involved in cytokinesis 0.027 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA14 -0.102 0.173 -9999.0 0.0 -0.394 127.0 127.0 GNA15 -0.008 0.047 -9999.0 0.0 -0.382 4.0 4.0 GNA12 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPT 0.024 0.061 -9999.0 0.0 -0.405 8.0 8.0 GNA11 -0.008 0.047 -9999.0 0.0 -0.382 4.0 4.0 Rac1/GTP -0.004 0.062 -9999.0 0.0 -0.982 2.0 2.0 MMP2 0.016 0.088 -9999.0 0.0 -0.826 5.0 5.0