Signaling events regulated by Ret tyrosine kinase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 -0.044 0.055 -9999.0 0.0 -9999.0 0.0 0.0 Crk/p130 Cas/Paxillin -0.099 0.139 -9999.0 0.0 -0.432 19.0 19.0 JUN -0.063 0.141 -9999.0 0.0 -0.415 16.0 16.0 HRAS 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/GRB10 -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/DOK1 -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 EntrezGene:5979 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Enigma -0.16 0.215 -9999.0 0.0 -0.476 125.0 125.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP -0.149 0.195 -9999.0 0.0 -0.428 129.0 129.0 GRB7 -0.005 0.051 -9999.0 0.0 -0.575 4.0 4.0 RET51/GFRalpha1/GDNF -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 MAPKKK cascade -0.128 0.172 -9999.0 0.0 -0.588 18.0 18.0 BCAR1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/IRS1 -0.16 0.215 -9999.0 0.0 -0.476 125.0 125.0 lamellipodium assembly -0.095 0.132 -9999.0 0.0 -0.4 19.0 19.0 RET51/GFRalpha1/GDNF/SHC -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/SHC -0.16 0.215 -9999.0 0.0 -0.476 125.0 125.0 RET9/GFRalpha1/GDNF/Shank3 -0.162 0.219 -9999.0 0.0 -0.425 191.0 191.0 MAPK3 -0.14 0.183 -9999.0 0.0 -0.618 20.0 20.0 DOK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DOK6 -0.063 0.206 -9999.0 0.0 -0.737 43.0 43.0 PXN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neurite development -0.14 0.179 -9999.0 0.0 -0.543 40.0 40.0 DOK5 -0.005 0.059 -9999.0 0.0 -0.656 4.0 4.0 GFRA1 -0.184 0.319 -9999.0 0.0 -0.737 125.0 125.0 MAPK8 -0.074 0.148 -9999.0 0.0 -0.441 16.0 16.0 HRAS/GTP -0.145 0.193 -9999.0 0.0 -0.437 129.0 129.0 tube development -0.151 0.205 -9999.0 0.0 -0.452 125.0 125.0 MAPK1 -0.14 0.183 -9999.0 0.0 -0.618 20.0 20.0 RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.102 0.143 -9999.0 0.0 -0.331 125.0 125.0 Rac1/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDLIM7 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok6 -0.191 0.246 -9999.0 0.0 -0.506 149.0 149.0 SHC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok4 -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 RET51/GFRalpha1/GDNF/Dok5 -0.171 0.223 -9999.0 0.0 -0.487 129.0 129.0 PRKCA -0.003 0.046 -9999.0 0.0 -0.737 2.0 2.0 HRAS/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREB1 -0.108 0.154 -9999.0 0.0 -0.361 125.0 125.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.102 0.143 -9999.0 0.0 -0.331 125.0 125.0 RET51/GFRalpha1/GDNF/Grb7 -0.171 0.22 -9999.0 0.0 -0.482 130.0 130.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET -0.02 0.104 -9999.0 0.0 -0.575 17.0 17.0 DOK4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade -0.062 0.139 -9999.0 0.0 -0.406 16.0 16.0 RET9/GFRalpha1/GDNF/FRS2 -0.16 0.215 -9999.0 0.0 -0.421 191.0 191.0 SHANK3 -0.003 0.046 -9999.0 0.0 -0.737 2.0 2.0 RASA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.102 0.144 -9999.0 0.0 -0.333 125.0 125.0 RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.105 0.142 -9999.0 0.0 -0.473 16.0 16.0 RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.105 0.142 -9999.0 0.0 -0.473 16.0 16.0 RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.105 0.143 -9999.0 0.0 -0.479 16.0 16.0 PI3K -0.142 0.202 -9999.0 0.0 -0.646 19.0 19.0 SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.151 0.205 -9999.0 0.0 -0.452 125.0 125.0 GRB10 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 activation of MAPKK activity -0.104 0.139 -9999.0 0.0 -0.478 16.0 16.0 RET51/GFRalpha1/GDNF/FRS2 -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 GAB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS2 -0.004 0.057 -9999.0 0.0 -0.737 3.0 3.0 RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.105 0.143 -9999.0 0.0 -0.479 16.0 16.0 RET51/GFRalpha1/GDNF/PKC alpha -0.17 0.22 -9999.0 0.0 -0.481 130.0 130.0 GRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GDNF -0.093 0.212 -9999.0 0.0 -0.575 81.0 81.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/IRS1 -0.168 0.218 -9999.0 0.0 -0.478 129.0 129.0 Rac1/GTP -0.112 0.158 -9999.0 0.0 -0.488 19.0 19.0 RET9/GFRalpha1/GDNF -0.177 0.237 -9999.0 0.0 -0.465 191.0 191.0 GFRalpha1/GDNF -0.204 0.271 -9999.0 0.0 -0.535 191.0 191.0