IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.004 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CD4-positive alpha-beta T cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response -0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 IL27/IL27R/JAK1 -0.028 0.097 -9999.0 0.0 -0.581 1.0 1.0 TBX21 -0.028 0.217 -9999.0 0.0 -0.62 43.0 43.0 IL12B 0.009 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IL12A 0.001 0.072 -9999.0 0.0 -0.564 8.0 8.0 IL6ST -0.018 0.141 -9999.0 0.0 -0.745 18.0 18.0 IL27RA/JAK1 -0.003 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IL27 0.008 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.011 0.003 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.06 0.141 -9999.0 0.0 -0.695 3.0 3.0 T-helper 2 cell differentiation -0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 T cell proliferation during immune response -0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade 0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB1 -0.038 0.183 -9999.0 0.0 -0.737 32.0 32.0 positive regulation of tyrosine phosphorylation of STAT protein -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.019 0.191 -9999.0 0.0 -0.652 11.0 11.0 IL27/IL27R/JAK2/TYK2 0.002 0.071 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of T cell mediated cytotoxicity 0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) -0.058 0.162 0.511 4.0 -0.752 7.0 11.0 JAK2 0.006 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JAK1 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 (dimer) 0.004 0.066 -9999.0 0.0 -9999.0 0.0 0.0 T cell proliferation -0.049 0.178 -9999.0 0.0 -0.513 27.0 27.0 IL12/IL12R/TYK2/JAK2 0.008 0.092 -9999.0 0.0 -0.589 2.0 2.0 IL17A -0.06 0.142 -9999.0 0.0 -0.696 3.0 3.0 mast cell activation -0.003 0.07 -9999.0 0.0 -9999.0 0.0 0.0 IFNG 0.006 0.02 -9999.0 0.0 -0.129 4.0 4.0 T cell differentiation -0.003 0.005 -9999.0 0.0 -0.022 4.0 4.0 STAT3 (dimer) 0.004 0.066 -9999.0 0.0 -9999.0 0.0 0.0 STAT5A (dimer) 0.004 0.066 -9999.0 0.0 -9999.0 0.0 0.0 STAT4 (dimer) -0.003 0.087 -9999.0 0.0 -0.475 6.0 6.0 STAT4 -0.012 0.092 -9999.0 0.0 -0.737 8.0 8.0 T cell activation -0.007 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IL27R/JAK2/TYK2 -0.019 0.08 -9999.0 0.0 -9999.0 0.0 0.0 GATA3 -0.033 0.235 -9999.0 0.0 -1.405 14.0 14.0 IL18 0.007 0.044 -9999.0 0.0 -0.565 3.0 3.0 positive regulation of mast cell cytokine production -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 IL27/EBI3 -0.002 0.041 -9999.0 0.0 -0.522 3.0 3.0 IL27RA 0.007 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IL6 -0.118 0.276 -9999.0 0.0 -0.738 82.0 82.0 STAT5A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 monocyte differentiation 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.001 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IL1B -0.003 0.084 -9999.0 0.0 -0.565 11.0 11.0 EBI3 0.001 0.054 -9999.0 0.0 -0.688 3.0 3.0 TNF -0.005 0.09 -9999.0 0.0 -0.554 13.0 13.0